CN1850300A - 一种复合生物材料及其制备方法 - Google Patents
一种复合生物材料及其制备方法 Download PDFInfo
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- CN1850300A CN1850300A CN 200610050190 CN200610050190A CN1850300A CN 1850300 A CN1850300 A CN 1850300A CN 200610050190 CN200610050190 CN 200610050190 CN 200610050190 A CN200610050190 A CN 200610050190A CN 1850300 A CN1850300 A CN 1850300A
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- polylactic acid
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- pla
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- hydroxyapatite
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- 239000002131 composite material Substances 0.000 title claims abstract description 20
- 239000012620 biological material Substances 0.000 title claims abstract description 13
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 35
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 35
- 239000004626 polylactic acid Substances 0.000 claims abstract description 35
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 31
- 238000002360 preparation method Methods 0.000 claims abstract description 11
- 229920000049 Carbon (fiber) Polymers 0.000 claims description 21
- 239000004917 carbon fiber Substances 0.000 claims description 21
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 21
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 239000000725 suspension Substances 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract description 3
- 229910052799 carbon Inorganic materials 0.000 abstract description 3
- 239000000835 fiber Substances 0.000 abstract description 3
- 239000000463 material Substances 0.000 description 17
- 210000000988 bone and bone Anatomy 0.000 description 7
- 206010061218 Inflammation Diseases 0.000 description 4
- 238000005452 bending Methods 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000012890 simulated body fluid Substances 0.000 description 4
- 208000010392 Bone Fractures Diseases 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 208000034530 PLAA-associated neurodevelopmental disease Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000007731 hot pressing Methods 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000004409 osteocyte Anatomy 0.000 description 1
- 230000002138 osteoinductive effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000012779 reinforcing material Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
本发明公开的复合生物材料含有重量百分比80-90%的聚乳酸、8.8-19.2%的羟基磷灰石、0.8-1.2%的碳纤维。制备步骤如下:按比例取聚乳酸、羟基磷灰石和碳纤维,先将聚乳酸和羟基磷灰石混合,加入溶剂氯仿,充分搅拌,得到聚乳酸/羟基磷灰石悬浮液,将碳纤维分散在聚乳酸/羟基磷灰石悬浮液中,挥发溶剂得到浸渍带,将浸渍带放入模具中,在10-12MPa压力,160-180℃温度下热压成型。发明的碳纤维增强羟基磷灰石/聚乳酸三元复合材料制备方法简单,与已有CF增强聚乳酸复合材料和HA/PLA复合材料相比,能克服酸性过大引起体内炎症、机械强度低、在X光片上显影差等缺点。
Description
技术领域
本发明涉及一种复合生物材料及其制备方法,尤其是碳纤维增强羟基磷灰石/聚乳酸复合生物材料及其制备方法
背景技术
聚乳酸(PLA)是可吸收聚合物,它具有无毒、无刺激和生物相容性好等特性,在人体内可降解成乳酸,而且自然代谢,无残留,因此广泛用作骨折修复材料、手术缝合线、控释药物等。尽管PLA具有很多优良的性能,但由于单纯的PLA骨折内固定装置机械强度较低,还不能满足很多功能骨骼的固定要求,因此须采用与其它材料复合达到增强的目的。而碳纤维(CF)则以其高强度和优良的生物相容性成为首选的PLA增强材料。但是,CF增强PLA由于降解产物呈酸性,易引起体内炎症反应,应用受到了限制。
羟基磷灰石(HA)具有良好的生物活性和骨传导性,能够与骨直接形成键性结合,大量地应用于骨替换植入材料。但其机械性能不佳,易脆,对负荷承载性差,不能完全适宜于骨组织工程的要求。将HA与PLA复合,可以提高材料韧性,满足骨替换植入材料的机械强度要求;可以解决PLA对X光片只有穿透能力,不利于显影观察的问题;而且PLA的酸性降解产物可被HA缓冲,同时HA的骨诱导性可提供良好的骨细胞粘附生长环境,复合物的多孔结构则为细胞生长、组织再生及血管化提供条件,符合骨组织工程的生物学要求,国内外已有这方面的报道。但是HA/PLA复合材料的机械强度也不理想,尤其不能满足大块骨段固定强度的要求。
发明内容
本发明的目的是提供一种高强度且具有很好的生物降解性能的复合生物材料及其制备方法。
本发明的复合生物材料,其组分及其重量百分比含量如下:
聚乳酸(PLA) 80~90%
羟基磷灰石(HA) 8.8~19.2%
碳纤维(CF) 0.8~1.2%
上述组分之和为100%。
发明的复合生物材料的制备方法,其步骤如下:
按比例取聚乳酸、羟基磷灰石和碳纤维,先将聚乳酸和羟基磷灰石混合,加入溶剂氯仿,充分搅拌,得到聚乳酸/羟基磷灰石悬浮液,搅拌下将碳纤维分散在聚乳酸/羟基磷灰石悬浮液中,常温下挥发溶剂得到浸渍带,将浸渍带放入模具中,在10-12MPa压力,160-180℃温度下热压成型。
本发明的有益效果在于:
发明的碳纤维增强羟基磷灰石/聚乳酸三元复合材料(CF/HA/PLA),其中CF提供力学性能,HA提供生物学性能,而PLA既起到了三元复合材料中的粘结性能,该材料制备方法简单,且与已有CF增强聚乳酸复合材料和HA/PLA复合材料相比,能克服酸性过大引起体内炎症、机械强度低、在X光片上显影差等缺点,可成为既具有生物活性,又具有可吸收性和降解性的高强度骨折内固定材料。
具体实施方式
实施例1
复合生物材料的组分及其重量百分比含量:聚乳酸(PLA)90%、羟基磷灰石(HA)9.0%、碳纤维(CF)1.0%。
制备方法:
按比例取PLA、HA和CF,先将PLA和HA混合,加入溶剂氯仿,充分搅拌,得到HA/PLA悬浮液,然后搅拌下将CF均匀分散在HA/PLA悬浮液中,常温下挥发溶剂得到浸渍带,将浸渍带放入模具中,将装有预浸带的模具放入热压机,在160℃和10MPa下热压20分钟成型,开模取出试样。
测试复合材料的力学性能和生物降解性能:
将制得的材料置于模拟体液(pH7.4的PBS液,配方:NaCl 137mmol/L,KCl 2.7mmol/L,Na2HPO4 4.3mmol/L,KH2PO4 1.4mmol/L)中,浸泡3个月,取出洗涤干燥,测定浸泡材料溶液的pH值变化和复合材料降解过程中的力学强度变化(见表1)。
表1
浸泡时间(月) | pH值 | 弯曲强度(MPa) | 弯曲模量(GPa) |
0 | 7.4 | 334 | 18.2 |
3 | 6.9 | 302 | 16.9 |
在模拟体液(pH7.4的PBS液)中浸泡6个月后,发现测试材料已经支离破碎,聚乳酸基本降解,可以被体液吸收,进而排出体外。测试浸泡材料溶液的pH值为7.0,不会引起体内炎症反应。
实施例2
复合生物材料的组分及其重量百分比含量:聚乳酸(PLA)85%、羟基磷灰石(HA)13.8%、碳纤维(CF)1.2%。
制备方法:
按比例取PLA、HA和CF,先将PLA和HA混合,加入溶剂氯仿,充分搅拌,得到HA/PLA悬浮液,然后搅拌下将CF均匀分散在HA/PLA悬浮液中,常温下挥发溶剂得到浸渍带,将浸渍带放入模具中,将装有预浸带的模具放入热压机,在170℃和12MPa下热压25分钟成型,开模取出试样。
测试复合材料的力学性能和生物降解性能:将制得的材料置于模拟体液(pH7.4的PBS液,配方同实施1)中,浸泡3个月,取出洗涤干燥,测定浸泡材料溶液的pH值变化和复合材料降解过程中的力学强度变化(见表2)。
表2
浸泡时间(月) | pH值 | 弯曲强度(MPa) | 弯曲模量(GPa) |
0 | 7.4 | 373 | 24.5 |
3 | 7.2 | 342 | 22.8 |
在模拟体液(pH7.4的PBS液)中浸泡6个月后,发现测试材料已经支离破碎,聚乳酸基本降解,可以被体液吸收,进而排出体外。测试浸泡材料溶液的pH值为7.3,不会引起体内炎症反应。
Claims (2)
1.一种复合生物材料,其特征是它的组分及其重量百分比含量如下:
聚乳酸 80~90%
羟基磷灰石 8.8~19.2%
碳纤维 0.8~1.2%
上述组分之和为100%。
2.根据权利要求1所述的复合生物材料的制备方法,其特征是步骤如下:
按比例取聚乳酸、羟基磷灰石和碳纤维,先将聚乳酸和羟基磷灰石混合,加入溶剂氯仿,充分搅拌,得到聚乳酸/羟基磷灰石悬浮液,搅拌下将碳纤维分散在聚乳酸/羟基磷灰石悬浮液中,常温下挥发溶剂得到浸渍带,将浸渍带放入模具中,在10-12MPa压力,160-180℃温度下热压成型。
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101249282B (zh) * | 2008-03-31 | 2011-05-18 | 陕西科技大学 | 一种用于骨修复的生物复合材料的制备方法 |
CN106676947A (zh) * | 2016-12-02 | 2017-05-17 | 中国科学院上海硅酸盐研究所 | 一种无机耐火纸及其制备方法和应用 |
CN109833513A (zh) * | 2019-03-08 | 2019-06-04 | 华南理工大学 | 一种高可降解性的羟基磷灰石支架及其制备方法和应用 |
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KR101161784B1 (ko) * | 2003-04-11 | 2012-07-05 | 에텍스 코포레이션 | 골 유도성 골 물질 |
CN1613512A (zh) * | 2003-11-04 | 2005-05-11 | 中南大学 | 生物可吸收内固定器件复合材料及制备方法 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101249282B (zh) * | 2008-03-31 | 2011-05-18 | 陕西科技大学 | 一种用于骨修复的生物复合材料的制备方法 |
CN106676947A (zh) * | 2016-12-02 | 2017-05-17 | 中国科学院上海硅酸盐研究所 | 一种无机耐火纸及其制备方法和应用 |
CN106676947B (zh) * | 2016-12-02 | 2018-09-28 | 中国科学院上海硅酸盐研究所 | 一种无机耐火纸及其制备方法和应用 |
CN109833513A (zh) * | 2019-03-08 | 2019-06-04 | 华南理工大学 | 一种高可降解性的羟基磷灰石支架及其制备方法和应用 |
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