CN1846707A - Compound nutrient for raising body's hypoxia tolerance - Google Patents
Compound nutrient for raising body's hypoxia tolerance Download PDFInfo
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- CN1846707A CN1846707A CN 200610013675 CN200610013675A CN1846707A CN 1846707 A CN1846707 A CN 1846707A CN 200610013675 CN200610013675 CN 200610013675 CN 200610013675 A CN200610013675 A CN 200610013675A CN 1846707 A CN1846707 A CN 1846707A
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Abstract
The present invention discloses one kind of compound nutrient for raising body's hypoxia tolerance. The compound nutrient includes the following ingredients: choline, carnitine, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, vitamin D, vitamin C, vitamin E and folic aid. The sealed anoxia experiment on mouse proves the function of the compound nutrient in raising body's hypoxia tolerance. The human body experiment in height of 3000-5000 m shows the functions of the compound nutrient in raising the saturation oxygen, improving cadio-pulmonary function, resisting fatigue, reducing altitude stress, etc.
Description
Technical field
The present invention relates to a kind of compound nutrients, particularly relate to a kind of compound nutrients that improves body's hypoxia tolerance.
Background technology
Altitude environment, high-intensity exercise or some disease such as atherosclerosis, myocardial infarction etc. all may cause the anoxia of body, influence the body normal physiological function, when serious with threat to life.Many studies have shown that, the nutriture of body and hypoxia-bearing capability have very confidential relation, but how to find a kind of anoxia patient that is suitable for, particularly be suitable for just to the region, plateau and a kind of material that improves body's hypoxia tolerance of the anoxia crowd of incompatibility altitude environment is a problem demanding prompt solution.
Summary of the invention
The purpose of this invention is to provide a kind of compound nutrients that improves body's hypoxia tolerance.
Technical scheme of the present invention is summarized as follows:
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component by weight: choline 80-120 part, carnitine 80-120 part, vitamin A 1.4-2.2 part, vitamin B
10.8-1.2 part, vitamin B
20.8-1.2 part, vitamin B
60.8-1.2 part, vitamin B
120.0016-0.0024 part, nicotinic acid 8-12 part, vitamin D 0.0016-0.0024 part, vitamin C 64-96 part, vitamin E 16-24 part, folic acid 0.08-0.12 part.
Preferably: described choline is 100 parts, and described carnitine is 100 parts, and described vitamin A is 1.8 parts, described vitamin B
1Be 1.0, described vitamin B
2Be 1.0 parts, described vitamin B
6Be 1.0 parts, described vitamin B
12Be 0.002 part, described nicotinic acid is 10 parts, and described vitamin D is 0.002 part, and described vitamin C is 80 parts, and described vitamin E is 20 parts, and described folic acid is 0.1 part.
A kind of compound nutrients that improves body's hypoxia tolerance can also comprise by weight: calcium pantothenate 1.6-2.4 part, inositol 20-30 part, vitamin K
10.04-0.06 part, biotin 0.008-0.012 part.
Preferably: described calcium pantothenate is 2 parts, and described inositol is 25 parts, described vitamin K
1Be 0.05 part, described biotin is 0.01 part.
A kind of compound nutrients that improves body's hypoxia tolerance can also comprise by weight: ferrum glycinate 30-37 part, calcium carbonate 400-600 part, zinc lactate 42-53 part.
Preferably: described ferrum glycinate is 33.33 parts, and described calcium carbonate is 500 parts, and described zinc lactate is 47.6 parts.
A kind of compound nutrients that improves body's hypoxia tolerance can also comprise by weight: copper oxide 1-1.5 part, potassium iodate 0.14-0.20 part, sodium selenite 0.05-0.08 part.
Preferably: described copper oxide is 1.25 parts, and described potassium iodate is 0.1695 part, and described sodium selenite is 0.06565 part.
A kind of compound nutrients that improves body's hypoxia tolerance of the present invention, by normal pressure hypoxia-bearing capability experimental technique in the national health food functional evaluation, the result proves: the time-to-live of taking behind the experimental mice airtight anoxia of a kind of compound nutrients that improves body's hypoxia tolerance of the present invention significantly is longer than matched group, illustrates that a kind of compound nutritional that improves body's hypoxia tolerance of the present invention have the effect that improves body's hypoxia tolerance.Carry out human trial in 3000 meters～5000m of height above sea level, the result shows that a kind of compound nutrients that improves body's hypoxia tolerance of the present invention has and improves experimenter's blood oxygen saturation, improves cardio-pulmonary function and memory function, resisting fatigue, alleviates effect such as altitude sickness.The present invention simultaneously also has the effect of the nutriture that improves body.
The specific embodiment:
The present invention is further illustrated below in conjunction with specific embodiment.
With a kind of compound nutrients that improves body's hypoxia tolerance of the present invention and pharmaceutically acceptable carrier mixed, make and be suitable for the dosage form that human body is taken, as tablet, capsule, solution by 1-10: 1-10.Also can make liquid beverage.
Pharmaceutically acceptable carrier can be chosen at least a from following substances: starch, dextrin, glucose, lactose, carboxymethyl cellulose, chocolate, stearic acid, silica gel, Pulvis Talci, syrup, ethanol, water.
Make the method that various preparation adopts and to select conventional method for use, as the preparation of tablet: ingredient inspection → pulverizing → feed proportioning → mixing → system soft material → granulation → oven dry → granulate → cooling → tabletting → coating → packing.
Embodiment 1
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 100 grams, carnitine 100 grams, retinol1 .8 gram, vitamin B
11.0 gram, vitamin B
21.0 gram, vitamin B
61.0 gram, vitamin B
120.002 gram, nicotinic acid 10 grams, vitamin D 0.002 gram, vitamin C 80 grams, vitamin E 20 grams, folic acid 0.1 gram.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 2
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 120 grams, carnitine 120 grams, vitamin A 1.4 grams, vitamin B
11.2 gram, vitamin B
21.2 gram, vitamin B
61.2 gram, vitamin B
120.0024 gram, nicotinic acid 8 grams, vitamin D 0.0024 gram, vitamin C 64 grams, vitamin E 24 grams, folic acid 0.12 gram.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 3
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 80 grams, carnitine 80 grams, vitamin A 2.2 grams, vitamin B
10.8 gram, vitamin B
20.8 gram, vitamin B
60.8 gram, vitamin B
120.0016 gram, nicotinic acid 12 grams, vitamin D 0.0016 gram, vitamin C 96 grams, vitamin E 16 grams, folic acid 0.08 gram.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 4
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 100 grams, carnitine 100 grams, vitamin A 1.8 grams, vitamin B
11.0 gram, vitamin B
21.0 gram, vitamin B
61.0 gram, vitamin B
120.002 gram, nicotinic acid 10 grams, vitamin D 0.002 gram, vitamin C 80 grams, vitamin E 20 grams, folic acid 0.1 gram, calcium pantothenate 2 grams, inositol 25 grams, vitamin K
10.05 gram, biotin 0.01 gram.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 5
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 120 grams, carnitine 120 grams, vitamin A 1.4 grams, vitamin B
11.2 gram, vitamin B
21.2 gram, vitamin B
61.2 gram, vitamin B
120.0024 gram, nicotinic acid 8 grams, vitamin D 0.0024 gram, vitamin C 64 grams, vitamin E 24 grams, folic acid 0.12 gram, calcium pantothenate 1.6 grams, inositol 30 grams, vitamin K
10.06 gram, biotin 0.008 gram.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 6
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 80 grams, carnitine 80 grams, vitamin A 2.2 grams, vitamin B
10.8 gram, vitamin B
20.8 gram, vitamin B
60.8 gram, vitamin B
120.0016 gram, nicotinic acid 12 grams, vitamin D 0.0016 gram, vitamin C 96 grams, vitamin E 16 grams, folic acid 0.08 gram, calcium pantothenate 2.4 grams, inositol 20 grams, vitamin K
10.04 gram, biotin 0.012 gram.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 7
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 100 grams, carnitine 100 grams, vitamin A 1.8 grams, vitamin B
11.0 gram, vitamin B
21.0 gram, vitamin B
61.0 gram, vitamin B
120.002 gram, nicotinic acid 10 grams, vitamin D 0.002 gram, vitamin C 80 grams, vitamin E 20 grams, folic acid 0.1 gram, ferrum glycinate 33.33 grams, calcium carbonate 500 grams, zinc lactate 47.6 grams.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 8
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 120 grams, carnitine 120 grams, vitamin A 1.4 grams, vitamin B
11.2 gram, vitamin B
21.2 gram, vitamin B
61.2 gram, vitamin B
120.0024 gram, nicotinic acid 8 grams, vitamin D 0.0024 gram, vitamin C 64 grams, vitamin E 24 grams, folic acid 0.12 gram, ferrum glycinate 30 grams, calcium carbonate 400 grams, zinc lactate 53 grams.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 9
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 80 grams, carnitine 80 grams, vitamin A 2.2 grams, vitamin B
10.8 gram, vitamin B
20.8 gram, vitamin B
60.8 gram, vitamin B
120.0016 gram, nicotinic acid 12 grams, vitamin D 0.0016 gram, vitamin C 96 grams, vitamin E 16 grams, folic acid 0.08 gram, ferrum glycinate 37 grams, calcium carbonate 600 grams, zinc lactate 42 grams.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 10
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 100 grams, carnitine 100 grams, retinol1 .8 gram, vitamin B
11.0 gram, vitamin B
21.0 gram, vitamin B
61.0 gram, vitamin B
120.002 gram, nicotinic acid 10 grams, vitamin D 0.002 gram, vitamin C 80 grams, vitamin E 20 grams, folic acid 0.1 gram, calcium pantothenate 2 grams, inositol 25 grams, vitamin K
10.05 gram, biotin 0.01 gram, ferrum glycinate 33.33 grams, calcium carbonate 500 grams, zinc lactate 47.6 grams.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 11
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 120 grams, carnitine 120 grams, vitamin A 1.4 grams, vitamin B
11.2 gram, vitamin B
21.2 gram, vitamin B
61.2 gram, vitamin B
120.0024 gram, nicotinic acid 8 grams, vitamin D 0.0024 gram, vitamin C 64 grams, vitamin E 24 grams, folic acid 0.12 gram, calcium pantothenate 1.6 grams, inositol 30 grams, vitamin K
10.06 gram, biotin 0.008 gram, ferrum glycinate 30 grams, calcium carbonate 400 grams, zinc lactate 53 grams.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 12
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 80 grams, carnitine 80 grams, vitamin A 2.2 grams, vitamin B
10.8 gram, vitamin B
20.8 gram, vitamin B
60.8 gram, vitamin B
120.0016 gram, nicotinic acid 12 grams, vitamin D 0.0016 gram, vitamin C 96 grams, vitamin E 16 grams, folic acid 0.08 gram, calcium pantothenate 2.4 grams, inositol 20 grams, vitamin K
10.04 gram, biotin 0.012 gram, ferrum glycinate 37 grams, calcium carbonate 600 grams, zinc lactate 42 grams.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 13
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 100 grams, carnitine 100 grams, retinol1 .8 gram, vitamin B
11.0 gram, vitamin B
21.0 gram, vitamin B
61.0 gram, vitamin B
120.002 gram, nicotinic acid 10 grams, vitamin D 0.002 gram, vitamin C 80 grams, vitamin E 20 grams, folic acid 0.1 gram, ferrum glycinate 33.33 grams, calcium carbonate 500 grams, zinc lactate 47.6 grams, copper oxide 1.25 grams, potassium iodate 0.1695 gram, sodium selenite 0.06565 gram.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 14
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 120 grams, carnitine 120 grams, vitamin A 1.4 grams, vitamin B
11.2 gram, vitamin B
21.2 gram, vitamin B
61.2 gram, vitamin B
120.0024 gram, nicotinic acid 8 grams, vitamin D 0.0024 gram, vitamin C 64 grams, vitamin E 24 grams, folic acid 0.12 gram, ferrum glycinate 30 grams, calcium carbonate 400 grams, zinc lactate 53 grams, copper oxide 1 gram, potassium iodate 0.20 gram, sodium selenite 0.08 gram.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 15
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 80 grams, carnitine 80 grams, vitamin A 2.2 grams, vitamin B
10.8 gram, vitamin B
20.8 gram, vitamin B
60.8 gram, vitamin B
120.0016 gram, nicotinic acid 12 grams, vitamin D 0.0016 gram, vitamin C 96 grams, vitamin E 16 grams, folic acid 0.08 gram, ferrum glycinate 37 grams, calcium carbonate 600 grams, zinc lactate 42 grams, copper oxide 1.5 grams, potassium iodate 0.14 gram, sodium selenite 0.05 gram.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 16
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 100 grams, carnitine 100 grams, vitamin A 1.8 grams, vitamin B
11.0 gram, vitamin B
21.0 gram, vitamin B
61.0 gram, vitamin B
120.002 gram, nicotinic acid 10 grams, vitamin D 0.002 gram, vitamin C 80 grams, vitamin E 20 grams, folic acid 0.1 gram, calcium pantothenate 2 grams, inositol 25 grams, vitamin K
10.05 gram, biotin 0.01 gram, ferrum glycinate 33.33 grams, calcium carbonate 500 grams, zinc lactate 47.6 grams, copper oxide 1.25 grams, potassium iodate 0.1695 gram, sodium selenite 0.06565 gram.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 17
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 120 grams, carnitine 120 grams, vitamin A 1.4 grams, vitamin B
11.2 gram, vitamin B
21.2 gram, vitamin B
61.2 gram, vitamin B
120.0024 gram, nicotinic acid 8 grams, vitamin D 0.0024 gram, vitamin C 64 grams, vitamin E 24 grams, folic acid 0.12 gram, calcium pantothenate 1.6 grams, inositol 30 grams, vitamin K
10.06 gram, biotin 0.008 gram, ferrum glycinate 30 grams, calcium carbonate 400 grams, zinc lactate 53 grams, copper oxide 1 gram, potassium iodate 0.20 gram, sodium selenite 0.08 gram.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 18
A kind of compound nutrients that improves body's hypoxia tolerance comprises following component:
Choline 80 grams, carnitine 80 grams, vitamin A 2.2 grams, vitamin B
10.8 gram, vitamin B
20.8 gram, vitamin B
60.8 gram, vitamin B
120.0016 gram, nicotinic acid 12 grams, vitamin D 0.0016 gram, vitamin C 96 grams, vitamin E 16 grams, folic acid 0.08 gram, calcium pantothenate 2.4 grams, inositol 20 grams, vitamin K
10.04 gram, biotin 0.012 gram, ferrum glycinate 37 grams, calcium carbonate 600 grams, zinc lactate 42 grams, copper oxide 1.5 grams, potassium iodate 0.14 gram, sodium selenite 0.05 gram.With above-mentioned each component, be mixed and made into solution in 1: 1 ratio and water, or according to a conventional method, make tablet or capsule.
Embodiment 19
Zoopery
1, animal
Healthy male mouse of kunming about body weight 25g, is provided by Military Medical Science Institute's animal center, freely drinks water, ingests, and feedstuff is the normal blocks material.Animal adapts to 5 days before the experiment.
2, acute hypoxia endurance test
Mice is put into the 250ml wide mouthed bottle that is lined with sodica calx, every bottle one Mus, tight with the rubber plug cover that scribbles vaseline, manual time-keeping mice life span.Experiment divides a kind of compound nutrients of body's hypoxia tolerance, a kind of compound nutrients that improves body's hypoxia tolerance of embodiment 7 of improving of normal control group, embodiment 1, every group 13, irritate stomach distilled water and embodiment 1, embodiment 7 every day respectively once, every 0.5ml, dosage is equivalent to 10 times of human body taking dose, totally 20 days.
3, result
During the zoopery, each treated animal body weight change does not have significant change.The life span that experimental result shows embodiment 1 a kind of compound nutrients that improves body's hypoxia tolerance, embodiment 7 a kind of improves after the compound nutrients animal acute anoxia of body's hypoxia tolerance significantly is longer than the normal control group, embodiment 1 be described a kind ofly improve the compound nutrients of body's hypoxia tolerance, a kind of compound nutrients that improves body's hypoxia tolerance of embodiment 7 all has the effect of raising body's hypoxia tolerance.
The comparison of chmice acute anoxia enduring life span is respectively organized in table 1 experiment
| Group | n | Life span (x ± S, min) |
| Normal control group embodiment 1 embodiment 7 | 13 13 13 | 8.66±1.12 10.27±2.07 * 9.76±1.37 * |
Variance analysis:
*Compare with the normal control group P＜0.05.
Embodiment 20
1, human trial one
Object: young male at 17～25 years old age, is divided into two groups, 20 every group.
Process: a kind of compound nutrients (embodiment 7) (tentative plateau by name dimension health sheet) that improves body's hypoxia tolerance of the present invention was taken after 20 days in 3700 meters, and radical 5000m are measured the concentration of heart rate, blood oxygen saturation and several nutrients of serum after one day.
The result:
Table 2 preparation of the present invention influences changes in heart rate
| 3700 meters | 5000m | |
| The matched group group of taking medicine | 81.5±11.0 84.3±15.8 | 94.6±8.6 87.2±13.4 |
| T-test | 0.25 | 0.02 |
By table 2 result as can be known, take a kind of compound nutrients that improves body's hypoxia tolerance of the present invention after, the heart rate increasing degree significantly reduces behind the radical 5000m plateau.
Table 3 preparation of the present invention is to the influence of blood oxygen saturation
| 3700 meters | 5000m | |
| The matched group group of taking medicine | 91.5±3.5 89.1±6.3 | 76.0±5.6 79.3±4.7 |
| T-test | 0.09 | 0.02 |
By table 3 result as can be known, take a kind of compound nutrients that improves body's hypoxia tolerance of the present invention after, experimenter's blood oxygen saturation fall significantly reduces behind the radical 5000m plateau.
Table 4 preparation of the present invention is to several important nutrient concentration change in the blood
| Before | After | |
| Vitamin A (μ g/100ml) vitamin B 2(nmol/L) magnesium (mg/L) calcium (mg/L) zinc (mg/L) | 18.35±5.31 11.48±7.05 16.22±2.23 74.53±8.03 1.21±0.56 | 38.76±9.77 28.55±17.69 20.59±8.91 84.31±20.70 1.91±0.62 |
By table 4 result as can be known, take the preparation of the present invention several important nutrient concentration in experimenter's blood that can raise.
2, human trial two
Method: select to migrate 3700 meters 40 Healthy Youth of 6 months of height above sea level, be divided into first at random, two groups of second, each organizes 20 people, first group (group of taking medicine) oral preparation of the present invention (embodiment 1), the oral fried flour preparation of second group (matched group), before moving before two groups all the multinomial psychological physiology tester detection of employing DDX-200 type computer is taken medicine before and after take medicine front and back and motion, take medicine before the motion after, take medicine moved in 10 days before, take medicine moved in 10 days after, before the drug withdrawal motion in 10 days, 10 days post exercise right-hand men of drug withdrawal hammer action frequency and digit span are carried on the back the binomial test in several six stages.Use EGM type bicycle and carry out load exercise (load index: W250P (175～180) inferior/minute).Carry out the test result contrast in two groups of six stages of first, second.
The result: the right-hand man is intersected hammer action frequency test: the first group took medicine 10 days move forward and backward and drug withdrawal motion in 10 days before than the second group relatively with the stage test result, errors number significantly reduces (P＜0.01), first group self relatively, take medicine moved in 10 days before and after and before the drug withdrawal 10 days motion, it is forward and backward to move before taking medicine, and errors number significantly reduces (P＜0.01).Digit span is carried on the back number test: the first group took medicine 10 days move forward and backward and drug withdrawal motion in 10 days forward and backward, self relatively reach with the second group with the stage relatively goals for significantly increase (P＜0.01).
Conclusion: oral preparation of the present invention (plateau dimension health sheet) can significantly improve genial plateau immigrant memory function and limb motion ability, and drug withdrawal still can keep certain anoxia enduring effect before moving after 10 days.
3, human trial three
Method: be divided into preparation of the present invention (plateau dimension health sheet) group (embodiment 13) and placebo group, 10 every group at random to moving into 6 months 20 Healthy Youth in height above sea level 3700m plateau.When peace and quiet, take medicine preceding, took medicine the 10th day and drug withdrawal was adopted cycle ergometer to carry out cumulative load exercise to power on the 10th day respectively to exhaust, measure aspartate aminotransferase (AST) in the serum, lactic acid dehydrogenase (LDH), alpha-hydroxybutyric dehydrogenase (α-HBDH), creatine kinase (CK) and isozyme (CK-MB) living-article thereof.
The result: plateau power exhausts motion makes AST, LDH, α-HBDH, CK and CK-MB content all increase (P＜0.05 or 0.01); Give preparation of the present invention (plateau dimension health sheet) and can obviously reduce myocardium enzyme activity (P＜0.05 or 0.01) in 10 days.Conclusion: plateau dimension health sheet has protective effect to the hypoxia exercise myocardial cell injury.
4, human trial four
Method: 20 Healthy Youth will moving into 3700 meters half a year of height above sea level are divided into plateau dimension health sheet group (embodiment 16) and matched group, every group 10 people at random.Do the seat treadmill movement with EGM type treadmill energy meter respectively at different time.Calculate every experimenter's PWC170 with return law of the straight line.
The result: plateau dimension health sheet group was taken medicine 10 days and drug withdrawal in the time of 10 days, and matched group increased significant difference (P＜0.05) before PWC170 took medicine.
Conclusion: plateau dimension health sheet can obviously improve the plateau and migrate young manual operation efficient.
5, human trial five
Method: be divided into plateau dimension health sheet group (embodiment at random to moving into 6 months 20 Healthy Youth in 3700 meters plateaus of height above sea level
10) and placebo group, 10 every group.When peace and quiet, take medicine preceding, take medicine and adopted cycle ergometer to carry out cumulative load exercise to power on the 10th day respectively to exhaust, measure total antioxidation vigor, superoxide dismutase, active oxygen and mda content in its serum.
The result: plateau power exhausts motion increases Total antioxidant capacity, active oxygen and mda content, the superoxide dismutase not statistically significant.Give plateau dimension health sheet and can obviously strengthen Total antioxidant capacity, superoxide dismutase activity, reduce the active oxygen activity.
Conclusion: plateau dimension health sheet strengthens the level of lipid due to the hypoxia exercise significant resistance inhibitor action, the generation of delayed motion fatigue.
6, human trial six
Method: 20 Healthy Youth will moving into 3700 meters half a year of height above sea level are divided into plateau dimension health sheet group (embodiment 4) and matched group, every group 10 people at random.The oral plateau of experimenter dimension health sheet 10 days, take medicine preceding, took medicine 10 days and drug withdrawal was done the seat treadmill movement with EGM type treadmill energy meter respectively in the time of 10 days.Initial load power 25W is with the continuous treadmill of 60r/min, and every 3min increases progressively 50W, stops behind the treadmill 3min when being incremented to 225W again.Per minute pulmonary ventilation volume (VE) and blood oxygen saturation (SaO when calculating every experimenter's motion power 225W
2).
The result: plateau dimension health sheet group was taken medicine 10 days and drug withdrawal 10 days, before VE takes medicine and matched group reduce significant difference (P＜0.05); SaO
2Reach matched group before taking medicine and increase significant difference (P＜0.05).
Conclusion: plateau dimension health sheet can improve the plateau and migrate young pulmonary ventilation and improve mechanical efficiency.
7, human trial seven
Method: 20 Healthy Youth will moving into 3700 meters half a year of height above sea level are divided into plateau dimension health sheet group (embodiment 10) and matched group, every group 10 people at random.The oral plateau of experimenter dimension health sheet 10 days, take medicine preceding, took medicine 10 days and drug withdrawal was done the seat treadmill movement with EGM type treadmill energy meter respectively in the time of 10 days.Initial load power 25W, with the continuous treadmill of 60rpm, every 3min increases progressively 50W, stops behind the treadmill 3min when being incremented to 225W again.Cardiac function index when by formula calculating every experimenter and testing at every turn.
The result: plateau dimension health sheet group was taken medicine 10 days and drug withdrawal in the time of 10 days, before cardiac function index is taken medicine and matched group increase, there was a significant difference (P＜0.05).
Conclusion: plateau dimension health sheet can obviously improve the plateau and migrate young cardiac function and mechanical efficiency.
8, human trial eight
Method: be divided into plateau dimension health sheet group (embodiment 16) and placebo group, 10 every group at random to moving into 6 months 20 Healthy Youth in 3700 meters plateaus of height above sea level.When peace and quiet, take medicine preceding, took medicine the 10th day and drug withdrawal was adopted cycle ergometer to carry out cumulative load exercise to power on the 10th day respectively to exhaust, measure packed cell volume (HCT), blood viscosity (η b), plasma viscosity (η p), reduced viscosity (η r), erythrocyte rigidity index (IR), red blood cell deformation coefficient (TK), erythrocyte aggregation coefficient (VAI) and TFL (TFL).
The result: 1. power exhausts motion back HCT, η b, η p, η r, IR, TK, VAI, TFL all raise (P＜0.05 or 0.01) when quiet.2. give obviously to reduce blood viscosity behind the dimension health sheet of plateau, improve erythrocyte deformability.
Conclusion: plateau dimension health sheet has the effect that microcirculation and hemorheological property are organized in improvement, and erythrocyte deformability is strengthened, and blood viscosity descends, and blood flow rate increases.
Claims (8)
1. a compound nutrients that improves body's hypoxia tolerance is characterized in that comprising by weight following component: choline 80-120 part, carnitine 80-120 part, vitamin A 1.4-2.2 part, vitamin B
10.8-1.2 part, vitamin B
20.8-1.2 part, vitamin B
60.8-1.2 part, vitamin B
120.0016-0.0024 part, nicotinic acid 8-12 part, vitamin D 0.0016-0.0024 part, vitamin C 64-96 part, vitamin E 16-24 part, folic acid 0.08-0.12 part.
2. a kind of compound nutrients that improves body's hypoxia tolerance according to claim 1 is characterized in that described choline is 100 parts, and described carnitine is 100 parts, and described vitamin A is 1.8 parts, described vitamin B
1Be 1.0 parts, described vitamin B
2Be 1.0 parts, described vitamin B
6Be 1.0 parts, described vitamin B
12Be 0.002 part, described nicotinic acid is 10 parts, and described vitamin D is 0.002 part, and described vitamin C is 80 parts, and described vitamin E is 20 parts, and described folic acid is 0.1 part.
3. a kind of compound nutrients that improves body's hypoxia tolerance according to claim 1 is characterized in that comprising by weight: calcium pantothenate 1.6-2.4 part, inositol 20-30 part, vitamin K
10.04-0.06 part, biotin 0.008-0.012 part.
4. a kind of compound nutrients that improves body's hypoxia tolerance according to claim 3 is characterized in that described calcium pantothenate is 2 parts, and described inositol is 25 parts, described vitamin K
1Be 0.05 part, described biotin is 0.01 part.
5. according to claim 1 or 3 described a kind of compound nutrientss that improve body's hypoxia tolerance, it is characterized in that comprising by weight: ferrum glycinate 30-37 part, calcium carbonate 400-600 part, zinc lactate 42-53 part.
6. a kind of compound nutrients that improves body's hypoxia tolerance according to claim 5 is characterized in that described ferrum glycinate is 33.33 parts, and described calcium carbonate is 500 parts, and described zinc lactate is 47.6 parts.
7. a kind of compound nutrients that improves body's hypoxia tolerance according to claim 5 is characterized in that comprising by weight: copper oxide 1-1.5 part, potassium iodate 0.14-0.20 part, sodium selenite 0.05-0.08 part.
8. a kind of compound nutrients that improves body's hypoxia tolerance according to claim 7 is characterized in that described copper oxide is 1.25 parts, and described potassium iodate is 0.1695 part, and described sodium selenite is 0.06565 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100136755A CN100418538C (en) | 2006-05-12 | 2006-05-12 | Compound nutrient for raising body's hypoxia tolerance |
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| CNB2006100136755A CN100418538C (en) | 2006-05-12 | 2006-05-12 | Compound nutrient for raising body's hypoxia tolerance |
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| CN1846707A true CN1846707A (en) | 2006-10-18 |
| CN100418538C CN100418538C (en) | 2008-09-17 |
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| CNB2006100136755A Expired - Fee Related CN100418538C (en) | 2006-05-12 | 2006-05-12 | Compound nutrient for raising body's hypoxia tolerance |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102334689A (en) * | 2011-10-10 | 2012-02-01 | 中国人民解放军军事医学科学院卫生学环境医学研究所 | Composite nutrient capable of improving physical ability of human body |
| CN110898069A (en) * | 2019-12-19 | 2020-03-24 | 青海大学 | 1,25-dihydroxy vitamin D3Pharmaceutical use in prevention and treatment of AMS |
| CN112021573A (en) * | 2020-05-26 | 2020-12-04 | 上海轻姿健康管理有限公司 | Sports nutritional composition for improving endurance |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT411958B8 (en) * | 1998-11-19 | 2004-09-27 | Jhs Privatstiftung | REFRESHING DRINK TO INCREASE ALCOHOL DEGRADING CAPACITY |
| US6299896B1 (en) * | 2000-04-13 | 2001-10-09 | Cooper Concepts, Inc. | Multi-vitamin and mineral supplement |
| US20040220118A1 (en) * | 2001-02-02 | 2004-11-04 | Bland Jeffrey S. | Medical composition for balancing bodily processes |
| US6524610B2 (en) * | 2001-02-26 | 2003-02-25 | Julia Muszynska | Nutritional composition made from conventional foods for mixing onsite in a blender and treating patients with hepatic disorders |
| US20030068391A1 (en) * | 2001-10-04 | 2003-04-10 | Harris Dennis H. | Ingestible nerve and circulatory nutritional formulation |
| CN1460518A (en) * | 2003-06-15 | 2003-12-10 | 刘蒙榕 | Composite enriched nutrient tablet |
-
2006
- 2006-05-12 CN CNB2006100136755A patent/CN100418538C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102334689A (en) * | 2011-10-10 | 2012-02-01 | 中国人民解放军军事医学科学院卫生学环境医学研究所 | Composite nutrient capable of improving physical ability of human body |
| CN110898069A (en) * | 2019-12-19 | 2020-03-24 | 青海大学 | 1,25-dihydroxy vitamin D3Pharmaceutical use in prevention and treatment of AMS |
| CN112021573A (en) * | 2020-05-26 | 2020-12-04 | 上海轻姿健康管理有限公司 | Sports nutritional composition for improving endurance |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100418538C (en) | 2008-09-17 |
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