CN1845719A - Mouth- and dental-care agent - Google Patents
Mouth- and dental-care agent Download PDFInfo
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- CN1845719A CN1845719A CNA2004800250942A CN200480025094A CN1845719A CN 1845719 A CN1845719 A CN 1845719A CN A2004800250942 A CNA2004800250942 A CN A2004800250942A CN 200480025094 A CN200480025094 A CN 200480025094A CN 1845719 A CN1845719 A CN 1845719A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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Abstract
The invention relates to oral and dental hygiene products comprising a) a composite material containing poorly water-soluble calcium salts in the form of nanoparticulate primary particles which are between 5 and 150 nm long and have a cross-section of between 2 and 50 nm, and protein constituents selected from proteins, protein hydrolysates and protein hydrolysate derivatives, and b) between 0.1 and 9 wt. % of a cleaning agent, in relation to the total weight of the product. The inventive oral and dental hygiene product ensures an effective and long-lasting remineralisation of the surface of the tooth, and a protective cleaning action of the cleaning or polishing agent.
Description
The present invention relates to oral cavity and dental hygiene product, it has the composite and the cleaning agent of certain content, thereby can guarantee gently to clean, and makes the dental surface remineralization simultaneously.
The oral cavity and the dentistry Cleasing compositions that comprise composite are disclosed, and wherein composite is made up of slightly molten nanoparticle calcium salt and protein component and cleaning and polishing agent.For example, WO01/01930 A1 discloses a kind of toothpaste based on 10wt.% silica abrasive and 5wt.% composite.The effect of composite is based on by the bone material of filling out the damage realization of covering on the dental surface and the biomineralization of tooth material.Comparatively speaking, grinding agent is the key component of any toothpaste preparation, is used for removing pollutant and precipitate on the tooth by grinding cleaning teeth.
EP 786 245 A1 disclose multiple oral cavity and dental hygiene product formulation, and it relates to the mixture of hydroxyapatite nano particle and cleaning agent.Hydroxyapatite is used to make the damage remineralization on the dental surface, also is used to prevent dental caries.Aluminium hydroxide and calcium phosphate are as cleaning agent, and it uses with high concentration.
When practical application, disclosed toothpaste preparation all is proved and can has problems among use WO 01/01930 A1 and EP 786245 A1, because the effect of grinding agent and remineralization component conflicts each other.Therefore, observe, particularly in about 2 to the 3 minutes short time when toothpaste acts on the oral cavity, the cleaning of grinding agent and polishing action have limited the deposition of remineralization component.Clearly, in cleaning course, grinding agent has been removed sedimentary remineralization component to a great extent once more.Therefore, importantly, the remineralization component has fabulous remineralization performance, thereby obtains gratifying remineralization effect in cleaning course.Compared various remineralization components such as conventional hydroxyapatite among Fig. 1, nano-grade hydroxy apatite and composite of the present invention show that their remineralization aspect of performance has tangible difference
Fig. 1 shows that in mimic 37 ℃ of salivas the pH that measures over time in various material 0.1% intensity dispersions.Used in the present invention simulate saliva is by 14mM Na
+, 4.7mM PO
4 3-, 21mM K
+, 30mM Cl
-, 1.8mM Ca
2+Aqueous solution form, thereby supersaturation in calcium phosphate.Use pH electrode (Inlab 310, Mettler Toledo: instrument: Consort, multi parameter analysis instrument C833) to measure pH.
Owing to the formation (that is, the remineralization effect) of hydroxyapatite in the saliva, it meets following equation to pH over time
Discharge acid in reaction, pH has reduced largely, and the remineralization effect of test material simultaneously becomes better.
Compare with conventional hydroxyapatite or nano-grade hydroxy apatite, the pH in the composite descends basically more precipitously, and this shows that composite has excellent remineralization performance.Therefore, be particularly suitable for as the remineralization component in the toothpaste preparation, and in toothpaste preparation the deposition of remineralization component always with the cleaning and the polishing action contradiction of grinding agent.
Yet except remineralization, oral cavity of the present invention and dental hygiene product also are used to guarantee gently to clean.
Yet, the amount of cleaning agent and performance and composition are all influential to remineralization, why Here it is the objective of the invention is to prepare the reason of oral cavity and dentistry Cleasing compositions, this compositions is dental treatments gently, thereby make the remineralization component have good deposition, reach gratifying cleaning efficacy simultaneously.
Surprisingly, by the detergent mixture of hybrid composite and low content, made have constant cleaning action (comparing) with the embodiment of WO 01/01930, have the oral cavity and a dental hygiene product of constant composite deposition simultaneously.So just guaranteed to dental surface especially gently but gratifying cleaning, simultaneously remineralization.
Also can distinguish compositions of the present invention by repair.Adamantine irregular and damage, for example the scratch that produces on enamel because of mechanism can polish by " filling " hydroxyapatite.Except the enamel surface of repairing damage, this also can produce the surface of create an aesthetic feeling.In addition, but prevent irritation sensitivity tooth, thus compositions of the present invention can realize the sensitivity cleaning.
Therefore, the present invention relates to a kind of oral cavity and dental hygiene product, its based on
A) a kind of composite comprises
-calcium salt, it is slightly water-soluble one-level nanoparticle, length is 5～150nm, the cross section be 2～50nm and
-be selected from albumen, the protein component of hydrolyzed protein and hydrolyzed protein derivant and
B) press the total restatement of product, the cleaning agent of 0.1～9wt.%.
Wherein composite comprises following composite, each component in comprising a), and be heterogeneous agglutination body on microcosmic, yet, they be uniformly on the macroscopic view, and wherein the one-level particle of calcium salt and the structure of protein component interrelate.Press the total restatement of composite, the ratio of protein component is 0.1～60wt.% in the composite, but is preferably 5～50wt.%, particularly 20～50wt.%.
The one-level particle refers to crystallite, i.e. each crystallite of described calcium salt.Particle diameter should be understood as that the vertical diameter that refers to the particle maximum.Mean diameter refers to the value that averages by the composite total amount.The method that available those skilled in the art were familiar with is measured particle diameter, for example observes from X-ray diffraction and carries out the Scherrer analysis.
The mean diameter of one-level nanoparticle is preferably 5～150nm and is preferably rod-shaped particle especially, and thickness is 2～50nm, and being in particular 3～8nm and length is 5～150nm, is in particular 10～40nm.Thickness refers to the minimum diameter of rod and the maximum gauge that length refers to rod.
In the preferred embodiment of the invention, its mean aspect ratio of nanoparticle rhabdolith is 3 to≤5, particularly about 4.Mean aspect ratio refers to that most of crystalline length-width ratio is in described scope among the present invention.Length-width ratio can be measured by the X-ray diffraction method equally.
TE microphotograph (200 000 * amplification shown in Figure 1 from the composite formed by hydroxyapatite and A type gel; 1cm is corresponding to 40nm among the figure), clearly illustrate that very much the space structure of the composite of forming by protein component and slightly molten nanoparticle calcium salt of the present invention.The high-molecular-weight protein component can be inferred three dimensional structure by measuring aminoacid sequence basically, deposits the bar-shaped hydroxyapatite nanoparticle on it, and therefore, to a certain extent, nanoparticle forms the image of the space structure of protein component.Fig. 2 shows that use edetate solution dissolves after the hydroxyapatite TE microphotograph (56000 * amplification of the A type gel structure of same compound material; 1.1cm is corresponding to 200nm among the figure).By one-level mechanism (aminoacid sequence) and depend on character, its secondary, three grades and the quarternary structure of protein component, can measure the mode on the basic structure that inorganic particulate is deposited on protein component.Find that surprisingly sedimentary spatial distribution of inorganic nano-particle and quantity are subjected to amino acid whose character and the number affects in the protein component on the protein component, thereby are subjected to the influence of the selection of protein component.Therefore, for example, by selecting to be rich in aminoacid, aspartic acid, the protein component of glutamic acid or cysteine, the slightly molten calcium salt of load especially in large quantities.Depend on these amino acid whose spatial distributions in the protein structure, can also have on the protein component of special space structure with slightly molten calcium salt load.
Therefore, described with people such as R.Z.Wang and exist the hydroxyapatite of equally distributed hydroxyapatite nano particle to compare with the collagen composite, composite of the present invention is the structuring composite.Further essential distinction between theme of the present invention and prior art is the size and the form of inorganic component.It is of a size of 2-10nm the hydroxyapatite particle that exists in the described hydroxyapatite of people such as R.Z.Wang-collagen composite.This size hydroxyapatite particle is amorphous or part X-ray amorphous substance.
Surprisingly, the present invention can produce the composite that contains the crystalline inorganic nanoparticle, wherein from microscope as can be seen nanoparticle have crystal habit.Fig. 1 shows the club shaped structure of inorganic nano-particle.Find that also compared with prior art, the structurized composite of the present invention can produce especially effectively biomineralization process.Can think, the micro structure of this and composite, particularly relevant with form with the size of crystals of calcium salts.Therefore, can think that the major axis of calcium salt nanoparticle is represented the preferred orientations of further crystalline growth in the biomineralization.
The molten salt of water part omitted is used in reference in the time of 20 ℃ dissolubility less than those salt of 1g/l.The preferred calcium salt that is fit to is calcium hydroxy phosphate (Ca
5[OH (PO
4)
3]) or hydroxyapatite, fluoro calcium phosphate (Ca
5[F (PO
4)
3]) or fluoro apatite, general formula Ca
5(PO
4)
3(OH, F) mix fluorine hydroxyapatite and calcium fluoride (CaF
2) or fluorite (fluorite); Hydroxyapatite and/or fluoro apatite are particularly preferred.
Composite of the present invention can comprise the multiple calcium salt in a kind of or the mixture, is selected from phosphate, and fluoride and fluoro phosphate selectively also comprise hydroxyl and/or carbonate group in the mixture.
Be applicable to that albumen of the present invention is all albumen basically, no matter be natural or preparation.The proteic example of animal origin is a keratin, elastin laminin, collagen, fibrin, albumin, casein, lactalbumin, placental protein.In these, the present invention is collagen preferably, keratin, casein, lactalbumin; Plant-derived albumen, for example, Semen Tritici aestivi and wheat germ protein, rice protein, soybean protein, avenin, Semen Pisi sativi protein, Rhizoma Solani tuber osi protein, almond protein and yeast protein are that the present invention is preferred equally.
Among the present invention, the hydrolyzed protein finger protein, for example, collagen, elastin laminin, casein, keratin, Semen Armeniacae Amarum, Rhizoma Solani tuber osi, Semen Tritici aestivi, the degradation products of rice and soybean protein can obtain by albumen itself or its degradation products (example gel) with acidity, alkalescence and/or enzyme hydrolysis.All enzymes with hydrolysing activity all are applicable to enzymatic degradation, for example, and alkaline protease.Other enzyme and enzymatic hydrolysis process that are fit to are disclosed in for example K.Drauz and H.Waldmann, EnzymeCatalysis in Organic Synthesis, and VCH-Verlag is among the Weinheim 1975.In degraded, albumen splits into less subunit, and degraded may be experienced polypeptide arrives single amino acids again to oligopeptide stage.The hydrolyzed protein of small amount of degradation comprises example gel, and gel is preferred in the present invention, and its molecular weight is 15 000～250 000D.Gel is the polypeptide that obtains by hydrolytic collagen matter under acid (A type gel) or alkalescence (Type B gel) condition basically.The gel strength of gel and its molecular weight are proportional, and promptly the gel of hydrolysis largely produces low viscosity solution.The Bloom exponential representation of the gel strength of gel.In the gel of enzymolysis, polymer sizes reduces greatly, thereby produces extremely low Bloom index.
Other preferred hydrolyzed proteins of the present invention are hydrolyzed proteins of using in the cosmetics, and its mean molecule quantity is 600～4000, is preferably 2000～3500 especially.The preparation of hydrolyzed protein and the summary of application are disclosed in for example G.Schuster and A.Domsch, Seifen le Fette Wachse 108 (1982) 177 and Cosm.Toil.99, (1984) 63, and H.W.Steisslinger, Parf.Kosm.72, (1991) 556, and people such as F.Aurich, among the Tens.Surf.Det.29 (1992) 389.Preferred use is from collagen among the present invention, keratin, the hydrolyzed protein that casein and vegetable protein (for example based on gluten or rice protein those) obtain, its preparation is disclosed in DE 19502167 C1 and DE 19502168 C1 (Henkel) in two pieces of Deutsche Bundespatents.
Among the present invention, the hydrolyzed protein derivant refers to the hydrolyzed protein of chemistry and/or chemical enzymology modification, for example, name is called the chemical compound of INCI, sodium type cocoyl hydrolyzed wheat protein, hydroxypropyl hydrolyzed wheat protein lauryl dimethyl quaternary ammonium salt, potassium type cocoyl hydrolytic collagen matter, potassium type undecylenic alcohol hydrolytic collagen matter and hydroxypropyl hydrolytic collagen matter lauryl dimethyl quaternary ammonium salt.Preferred use is collagen among the present invention, keratin and casein, and the derivant of the hydrolyzed protein of plant protein hydrolysate (for example, sodium type cocoyl hydrolyzed wheat protein or hydroxypropyl hydrolyzed wheat protein lauryl dimethyl quaternary ammonium salt).
Belong to the hydrolyzed protein of the scope of the invention and other examples of hydrolyzed protein derivant and be disclosed in CTFA 1997 International Buyers ' Guide, people (Ed.) such as John A.Wenninger, The Cosmetic, Toiletry, and Fragrance Association, Washington DC1997 is among the 686-688.
In every kind of composite of the present invention, can be by being selected from albumen, one or more materials of hydrolyzed protein and hydrolyzed protein derivant form protein component.
Preferred protein component all is the albumen that forms structure, hydrolyzed protein and hydrolyzed protein derivant, because the chemical composition of protein component, so the three-D space structure that the protein component finger-type becomes the affiliated technical staff of albumen chemical field to be familiar with, title is secondary, three grades or quarternary structure.Be the preparation composite, particularly can be with reference to the disclosure among WO 01/01930 A1.
Press the total restatement of product, the composite amount in oral cavity of the present invention and the dental hygiene product is 0.01～10wt.%, preferred 0.01～2wt.%.
Oral cavity of the present invention and dental hygiene product also comprise at least a cleaning agent of 0.1～9wt.%, particularly 2～8wt.%.
Cleaning agent is the solvent of toothpaste, and depends on that its expectation function mixes use separately or with other cleaning agent or polishing agent.They are used for mechanically removing the dental plaque of not calcification, and in the ideal case, should be able to make dental surface (polishing action) light, simultaneously to enamel and Dentinal souring (abrasive action) and damage minimum.The nonferromagnetic substance of polishing agent and cleaning agent can be measured according to their hardness, particle size distribution and surface texture basically.Therefore, when the cleaning agent that select to be fit to, those that particularly have minimum abrasive action and an abrasive effect are preferred.
Be those of small particle diameter as the material of cleaning agent now, they do not have sharp-pointed angle and edge basically, and its hardness and mechanical performance can not produce excess pressure to tooth or tooth material.
Water insoluble inorganic substance matter is usually as cleaning agent or polishing agent.The particularly advantageous fines polishing agent that is to use, its mean diameter are 1-200 μ m, preferred 1-50 μ m, particularly 1-10 μ m.
Polishing agent of the present invention is selected from silicon oxide basically, aluminium hydroxide, aluminium oxide, silicate, organic polymer or its mixture.Yet product of the present invention also can comprise so-called metaphosphate, alkaline earth metal carbonate or bicarbonate and calcic polishing component.
The present invention preferably uses silicon oxide as polishing agent in toothpaste or liquid dental Cleasing compositions.In the silicon oxide polishing agent,, between hydrogel silicon oxide and the sedimentary silicon oxide obvious difference is arranged at the gel silicon oxide.Sedimentary and gel silicon oxide is particularly preferred for the present invention, because various variations are good especially in the fluoride active substance.In addition, they also are particularly suitable for preparing gel or liquid tooth paste.
By making the reaction of sodium silicate solution and strong inorganic acid form the hydrosol, the aging hydrogel that is called washs drying again, thus preparation gel silicon oxide.Being dried to water content under temperate condition is 15～35wt.%, obtains so-called hydrogel silicon oxide, and this for example also is disclosed among the US 4,153,680.Dry this hydrogel silicon oxide to water content is lower than 15wt.%, can make loose structure before this irreversibly be shrunk to so-called xerogel compact texture.This xerogel silicon oxide for example is disclosed among the US 3,538,230.
Second group of silicon oxide polishing agent that preferably is fit to is sedimentary silicon oxide.By not taking place under the agglutinative condition, add strong acid precipitated silica from the alkali metal silicate solutions of dilution and prepare at colloidal sol and gel.The appropriate methodology for preparing sedimentary silicon oxide for example is disclosed among the DE-A 2,522 586 and DE-A 31 14 493.Being particularly suitable for of the present invention is that its BET surface area is 15-110m by the sedimentary silicon oxide for preparing described in the DE-A 31 14 493
2/ g, particle diameter are 0.5～20 μ m, and specification is that the one-level particle of 80wt.% at least is lower than 5 μ m, and in the toothpaste of 10-20wt.%, in glycerol-water (1: 1) dispersion of 30% intensity, its viscosity is 30-60Pas (20 ℃).The preferred sedimentary silicon oxide that is fit to has fillet and limit, and proprietary term Sident for example
12DS obtains from Degussa
Other such precipitated silicas are the Sident that obtain from Degussa
8 and the Sorbosil that obtains from Crosfield Chemicals
AC 39.The feature of these silicon oxides is that mean diameter, the specific surface area of less thickening power, bigger 8-14 μ m is 40-75m
2/ g (BET), and be specially adapted to liquid tooth paste.The viscosity of these silicon oxides (25 ℃, shear rate D=10s
-1) be 10-100Pa s.
Can also use the Zeodent that obtains from Huber-Corp. among the present invention
Silicon oxide, the Tixosil that obtains from Rhodia
Silicon oxide and other Sorbosil type silicon oxides.Zeodent
113, Tixosil
123 and Sorbosil
AC39 is particularly preferred.
Comparatively speaking, viscosity greater than 100Pas (25 ℃, D=10s
-1) toothpaste need the silicon oxide of the particle diameter of relatively large ratio less than 5 μ m, preferred 3wt.% particle diameter at least is the silicon oxide of 1～3 μ m.Except described sedimentary silicon oxide, can also be added in this toothpaste is so-called thickening silicon oxide, and it has thinner particle, and the BET surface area is 150-250m
2/ g.Meet the Sipernat that the commercial examples of described condition particularly obtains from Degussa
22 LS or Sipernat
320 DS.
Aluminium oxide polishing agent that be fit to and preferred is incinerating slightly aluminium oxide, press the total restatement of product, and α-be about 0.01～5wt.% with the amount of gama-alumina is preferably 0.1～2wt.%.
The incinerating slightly aluminium oxide that is fit to prepares by calcinations of aluminum hydroxide.Change into by calcinations of aluminum hydroxide and to be higher than thermodynamically stable α-Al under 1200 ℃ of temperature
2O
3The Al of thermodynamic instability
2O
3Variant appears at 400～1000 ℃ usually, be called as the γ type (referring to Ullmann, Enzyclop die der technischen Chemie, the 4th edition (1974), Volume 7, the page or leaf 298).Degree of calcination promptly changes into thermodynamically stable α-Al
2O
3Degree, can be arranged on any level by selecting calcining heat and time.Slightly microincineration obtains containing γ-Al
2O
3Aluminium oxide, and the calcination time selected higher when the calcining heat of selecting be than long time, γ-Al
2O
3Content is lower.Incinerating slightly aluminium oxide is different from pure α-Al
2O
3, the former agglutination body is not too hard, specific area is big and pore volume is bigger.
γ-Al in the used incinerating slightly aluminium oxide among the present invention
2O
3Ratio is 10-50wt.%, and its dentin grinds (RDA) and only is equivalent to highly incinerating pure α-Al
2O
3The 30-60% that grinds of dentin (in standard toothpaste, measure, with the 20wt.% aluminium oxide as only polishing agent).
With α-Al
2O
3Compare, can be with the ammonia aqueous solution of alizarin S (1,2-di hydroxyl-9,10-anthraquinone-4-sulfonic acid) from γ-Al
2O
3Obtain redness.The pigmentable degree can be selected for measures degree of calcination or δ-Al
2O
3Ratio in incinerating aluminium oxide: will about 1gAl
2O
3, 10ml 3g/l alizarin S aqueous solution and 3 10wt.%NH
3Aqueous solution is added in the test tube, and simply boils.Filter out Al then
2O
3, washing, drying in the microscopically analysis, or is used colorimetrically analysing.
According to said method, the γ-Al of Shi Heing
2O
3Content is that the incinerating slightly aluminium oxide of 10-50wt.% shows from the canescence to the rediance.
Various degree of calcinations, the aluminium oxide polishing agent that grinds fineness and bulk density can obtain from commercial, for example " Poliertonerden " that obtains from Giulini-Chemie or ALCOA.
Preferred its agglutination body size of " Poliertonerde P10 feinst " class that is fit to is less than 20 μ m, and average one-level crystallite dimension is 0.5-1.5 μ m, and bulk density is 500-600g/l.
The silicate that the present invention also preferably uses is as the polishing agent component.In using at present, they are particularly useful as cleaning agent.Can be used for silicate example of the present invention is aluminium silicate and Zirconium orthosilicate..Empirical formula is Na
12(AlO
2)
12(SiO
2)
12* 7H
2The sodium aluminosilicate of O is particularly suitable for as polishing agent, for example, and synthetic zeolite A.
The example of water-insoluble metaphosphate of the present invention is Polymeric sodium metaphosphate. particularly, calcium phosphate, for example, calcium triphosphate, calcium hydrogen phosphate, dicalcium phosphate dihydrate and calcium pyrophosphate.
The present invention also may use magnesium carbonate, and magnesium hydrogen phosphate, tricresyl phosphate magnesium or sodium bicarbonate particularly mix with other polishing agents as polishing agent.
Be applicable to that other polishing agents in oral cavity of the present invention and the dental hygiene product are calcium phosphate dihydrate (CaHPO
4* 2H
2O).Calcium phosphate dihydrate is natural brushite, can obtain from commercial, and its particle diameter that is fit to during as polishing agent is 1～50 μ m.
Preferred oral cavity of the present invention and dental hygiene product are also to comprise 0.1～10wt.% by the total restatement of product, the remineralization of preferred 0.1～5wt.% and special 0.1～3wt.% promotes those of component, thereby helps to carry out those of remineralization process by composite.
Remineralization in the product of the present invention promotes component to promote the sealing of adamantine remineralization and injury of teeth, and be selected from fluoride, the phosphate of the calcium of microgranule, for example, calcium glycerophosphate, calcium hydrogen phosphate, hydroxyapatite, fluoro apatite, F-adulterated hydroxyapatite, dicalcium phosphate dihydrate and calcium fluoride.Yet magnesium salt also has the remineralization effect, for example, and magnesium sulfate, Afluon (Asta) or single fluoro magnesium phosphate.
The preferred remineralization of the present invention promotes that component is a magnesium salt.
Oral cavity and dental hygiene product that the present invention is fit to embodiment are solid, liquid or semiliquid toothpaste and tooth gel.
In other embodiment preferred, oral cavity of the present invention and dental hygiene product comprise other toothpaste components, as surfactant, and wetting agent, binding agent, flavoring agent and the active substance that is used to prevent tooth and gum disease.
For cleaning action and the foam that improves oral cavity of the present invention and dental hygiene product forms, use surface-active surfactant or surfactant mixture usually.They can promote toothpaste to dissolve fast and completely in the oral cavity and distribute, and help mechanically to remove dental plaque simultaneously, particularly in the inaccessible position of toothbrush.In addition, they help to add water-insoluble materials (for example aromatic oil), stablize the polishing agent dispersion, and help the dental caries effect of fluoride.
Basically can use anion surfactant, amphion and amphoteric surfactant, non-ionic surface active agent, the mixture of cationic surfactant or these chemical compounds is as the surfactant in the toothpaste preparation.Toothpaste of the present invention preferably includes at least a surfactant that is selected from anion surfactant.
In compositions of the present invention, by the total restatement of compositions, the common consumption of surfactant or surfactant mixture is 0.1-10wt.%, is preferably 0.3-7wt.% and is in particular 1-5wt.%.
Anion surfactant
Suitable surfactant with good barbotage is an anion surfactant, and they also have certain enzyme inhibition to the metabolism of antibacterial on the dental plaque.
These comprise for example C
8-C
18-alkanecarboxylic acid has 12-16 carbon atom, has the alkyl polyglycol ether sulphuric acid of 2-6 ethylene glycol ether group in molecule, linear paraffin-(C in straight chained alkyl
12-C
18The alkali metal salts or ammonium salt of)-sulfonic acid, particularly sodium salt, sulfo-succinic acid monoalkyl (C
12-C
18) ester, sulphation glycerine monofatty ester, sulphation Marlamid, thiacetic acid. alkyl (C
12-C
16) ester, in acyl group, have acyl group sarcosine, acyl amino esilate and the acyl isethinate of 8-18 carbon atom in each case.
Preferably use at least a anion surfactant, particularly in alkyl, have the lauryl alkyl sodium sulfate of 12-18 carbon atom.Such a kind of surfactant is for example commercial with title Texapon
The sodium lauryl sulfate that K12G obtains.
Amphion and amphoteric surfactant
The present invention preferably uses amphion and/or amphoteric surfactant, preferably uses with anion surfactant.Surface-the reactive compound that has at least one quaternary ammonium group and at least one carboxylate radical and a sulfonate radical in molecule is known as zwitterionic surfactant.Particularly suitable zwitterionic surfactant is so-called betanin; as N-alkyl-N; the glycinate of N-Dimethyl Ammonium; the glycinate of trimethyl ammonium for example; the glycinate of cocoa alkyl dimethyl ammonium; N-acyl group aminopropyl-N; the glycinate of N-dimethyl-ammonium; the glycinate of cocoa acyl group aminopropyl Dimethyl Ammonium for example; with 2-alkyl-3-carboxy methyl-3-hydroxyethyl imidazoline; and in alkyl or acyl group, has 8～18 carbon atoms and cocoa acyl group aminoethyl hydroxyethyl carboxyl methylglycine salt in each case.The fat amide derivant of the cocoa amido propyl betaine of CTFA title is particularly preferred.This product is commercial for example with title Tego-Betain
BL215 and ZF50, and Genagen
CAB obtains.
Amphoteric surfactant refers in molecule except C
8-C
18Outside-alkyl or the acyl group, also comprise at least one free amino group and at least one-COOH or-SO
3The H group also can form those surface-reactive compounds of inner salt.The example of the amphoteric surfactant that is fit to is the N-p dialkylaminobenzoic acid; N-alkyl propanoic acid; N-alkyl amino butanoic acid; N-alkyl-imino-diacetic propanoic acid; N-hydroxyethyl-N-alkyl amido propyl group glycine, N-alkyl taurine, N-alkyl sarcosine; 2-alkyl aminopropionic acid and p dialkylaminobenzoic acid, and in alkyl, have about 8～18 carbon atoms in each case.Particularly preferred amphoteric surfactant is a N-cocoa alkyl aminopropionic acid salt, cocoa acyl group aminoethyl aminopropionate and C
12-C
18-acyl group sarcosine.Except both sexes, quaternized emulsifying agent also is fit to, and particularly preferably is season ester type, preferable methyl-quaternised difatty acid triethanolamine ester salts.
Non-ionic surface active agent
Non-ionic surface active agent helps cleaning action in the present invention especially.Particularly preferred non-ionic surface active agent be selected from below at least one:
The straight-chain fatty alcohol of-2～30mol oxirane and/or 0～5mol expoxy propane and 8～22 carbon atoms has the addition product of the alkyl phenol of 8～15 carbon atoms in the fatty acid of 12～22 carbon atoms and the alkyl;
The C of the addition product of-1～30mol oxirane and glycerol
12-C
18The fatty acid list-and diester;
The glycerol list of the saturated and unsaturated fatty acid of-6～22 carbon atoms-and diester and sorbitan list-and diester and their ethylene oxide adduct;
-in alkyl, have the alkyl list of 8～22 carbon atoms-and oligoglycosides and their ethoxylation analog;
The addition product of-15～60mol oxirane and Oleum Ricini and/or hardened Oleum Ricini;
-polyol ester and particularly polyglycerin ester, for example, polyglycerol polyricinoleate, polyglycereol gathers-12-hydroxy stearic acid ester or polyglycereol dimer.
What be fit to equally is a plurality of mixture that belong to the chemical compound of this class material;
The addition product of-2～15mol oxirane and Oleum Ricini and/or hardened castor oil;
-partial ester is based on straight chain, side chain, unsaturated or saturated C
6-C
22Fatty acid, castor oil acid and 12-hydroxy stearic acid and glycerol, polyglycereol, tetramethylolmethane, dipentaerythritol, sugar alcohol (for example Sorbitol), sucrose, alkyl androstanediol (for example methyl glucosamine, butyl glucoside, lauryl glucoside) and polyglucoside (for example cellulose);
-single-, two-and trialkyl phosphates, and single-, two-and/or three-PEG alkyl phosphate and their salt;
-Pilus Caprae seu Ovis ceryl alcohol;
-polysiloxanes-poly-alkyl-copolyether and corresponding derivant;
Disclosed tetramethylolmethane among the-DE 1165574, fatty acid, the mixed ester of citric acid and aliphatic alcohol and/or have the fatty acid of 6～22 carbon atoms, the mixed ester of methyl glucoside and polyhydric alcohol (preferably glycerine and polyglycereol) and
-Polyethylene Glycol.
Oxirane and/or expoxy propane and aliphatic alcohol, fatty acid, the addition product of alkyl phenol, the glycerol list of fatty acid-and diester and sorbitan list-and diester or with the addition product of Oleum Ricini be commercial known product, be preferred in the present invention.They are mixture of homologue, and the average alkoxide degree of homologue is corresponding to the ratio of oxirane and/or the expoxy propane and the amount of the substrate that carries out additive reaction.The C of the addition product of oxirane and glycerol
12-C
18Fatty acid list-be disclosed among the DE 2024051 with diester is as the reagent of fatization again of cosmetic formulations.C
8-C
18-alkyl list-and oligoglycosides, its preparation and its purposes are known in the art, and for example are disclosed in US-A-3, and 839,318, DE-A-20 36 472, among EP-A-77 167 or the WO-A-93/10132.Particularly can form preparation by the primary alconol reaction that makes glucose or oligosaccharide and 8～18 carbon atoms.In the glucosides residue, wherein the monoglycosides that is connected by glucosides of ring-type saccharide residue and aliphatic alcohol and the oligoglycosides of oligomeric degree preferred about 8 are fit to.In this one side, oligomeric degree is based on the equally distributed assembly average of this industrial products.Suitable and preferred alkyl (oligomeric) glucosides is formula RO (C
6H
10O)
xThe alkyl of-H (oligomeric) glucosides, wherein R is the alkyl with 12～14 carbon atoms, the meansigma methods of x is 1～4.
The more preferred example of used non-ionic surface active agent for example is commercial with Tagat among the present invention
The PEG-glyceryl stearate that the S title obtains.
Wetting agent prevents product drying and the control uniformity and low-temperature stability usually in the dentistry cosmetics.Yet they also are used for promoting to suspend and influence taste or gloss.
Wetting agent commonly used is the acceptable polyhydric alcohol of toxicology, Sorbitol for example, xylitol, glycerol, mannitol, 1,2-propylene glycol or its mixture; Yet molecular weight is that the Polyethylene Glycol of 400-2000 also can be as the wetting agent in the toothpaste.
Preferably mix multiple wetting agent component, wherein mix glycerol and Sorbitol and 1,2-propylene glycol or Polyethylene Glycol are considered to particularly preferred.
Depend on product category, in total composition, the amount of wetting agent or wetting agent mixture is 10-85wt.%, is preferably 15-70wt.%, particularly 25-50wt.%.
In preferred embodiments, product of the present invention also comprises at least a binding agent or thickening agent.These are used to control the uniformity, also are used to prevent separating of liquid and solid constituent.
Its amount used in compositions of the present invention is 0.1-5wt.%, is preferably 0.1-3wt.%, particularly 0.5-2wt.%.
The used example of the present invention is natural and/or synthetic polymer, as alginate, and carrageenin, agar, guar gum, arabic gum, succinyl polysaccharide glue, melon ear powder, carob powder, tragacanth, karaya, xanthan gum, colloid, cellulose and their ion and non-ionic derivate, for example, carboxy methyl cellulose, hydroxyethyl-cellulose or methyl hydroxy propyl cellulose, hydrophobic modified cellulose, starch and starch ether.
Be water solublity carboxyl polyvinyl (Carbopol for example also as binding agent or thickening agent
Type), polyvinyl alcohol, (particularly molecular weight is 10 for polyvinylpyrrolidone and high molecular weight polyethylene glycol
2-10
6Those of D).This function also can realize by sheet silicate and fine-particle silica (aeroge silicon oxide and fumed silica).
In other embodiment preferred, oral cavity of the present invention and dental hygiene product comprise other active substances that are used to prevent dentistry and gum disease.This active substance refers to the dental caries active substance among the present invention, antibacterial substance, tartar inhibitor, the combination in any of flavoring agent or these materials.
The dental caries active substance
Be specially adapted to control with caries prevention be the fluorine compounds that contain the 0.1-0.5wt.% fluorine, preferred fluorinated thing or single fluoro phosphate.The fluorine compounds that are fit to for example are sodium fluoride, potassium fluoride, stannic fluoride, single fluoro disodium hydrogen phosphate (Na
2PO
2F), the fluoride of single fluoro dikalium phosphate or organic amino compounds.
Antibacterial substance
The example of the antibacterial components that is fit to is a phenol, resorcinol, bis-phenol, salicyl aniline and their halide derivative, halogenated carbanilide and p-Hydroxybenzoate.
Particularly suitable antibacterial components is to suppress those of speckle bacteria growing.The suitable example of antibacterial substance is a halogenated diphenyl ethers, as 2, and 4-two chloro-2 '-dihydroxy diphenyl ether, 4,4 '-two chloro-2 '-dihydroxy diphenyl ethers, 2,4,4 '-three bromo-2 '-dihydroxy diphenyl ethers, 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers (triclosan).Except bromochlorobenzene, two biguanide such as chlorhexidine and alexidine, phenyl salicylic acid esters and 5-amino-1 are outside two (2-ethylhexyl) six hydrogen of 3--5-methylpyrimidine (hexetidine), zinc and copper ion also have antibacterial action, and have synergism with hexetidine and triclosan.Also may use quaternary ammonium compound, for example, pyrisept, zephiran chloride, Bradosol Bromide (domiphene bromide) and dequalinium chloride.Octapinol, Octenidine and Sanguinarine also are proved has antibacterial activity.
The preferred antibacterial substance amount of using is 0.01-1wt.% in the product of the present invention.Particularly preferably be the Irgacare that use amount is 0.01-0.3wt.%
MP.
The tartar inhibitor
Tartar comprises the mineral deposit with the Natural tooth Enamel fairly similar.Form for suppressing tartar, particularly, intervene nucleus formation and prevent that the material of nucleus further growth is added in the dentistry Cleasing compositions of the present invention.Its example is a condensed phosphate, is preferably selected from tripolyphosphate, pyrophosphate, trimetaphosphate or its mixture.They use with the form of alkali metal salts or ammonium salt, preferably the form of sodium salt or potassium salt.These phosphatic aqueous solutions have alkalescence usually, thereby when needed, are adjusted to 7.5-9 by adding sour pH value with dental hygiene product of the present invention.The example of operable acid is a citric acid, phosphoric acid or ackd salt, for example NaH
2PO
4Yet, also can be by in condensed phosphate, adding the pH value that superphosphate is regulated the dental hygiene product, for example K
2H
2P
2O
7
Also can use the mixture of various condensed phosphates and/or the hydrated salt of condensed phosphate among the present invention.In product of the present invention, the usual amounts of tartar inhibitor is 0.1-5wt.%, is preferably 0.1-3wt.%, particularly 0.1-2wt.%.
Other tartar inhibitor that are fit to are organic phosphonates, as 1-azepan-2, and 2-diphosphate (Na salt), 1-hydroxyl ethane-1,1-diphosphate (Na salt) and zinc citrate.
Prevent the active substance of hypersensitization tooth
Product of the present invention preferably also comprises the active substance that prevents the hypersensitization tooth, and they are selected from potassium and strontium salt such as potassium chloride, potassium sulfate, potassium bicarbonate, potassium citrate, potassium acetate, potassium nitrate, strontium chloride, strontium nitrate, strontium citrate, strontium acetate, strontium lactate and acetaminol.
Acetaminol can mix with the aromatic oil in oral cavity and the dental hygiene product.The form of clove bud oil preferably in compositions.
Oral cavity of the present invention and dental hygiene product preferably include the acetaminol of the 0.01wt.% at least of the potassium of 0.5wt.% of dissolved at least salt form or strontium ion and pure form or clove bud oil form.
Flavoring agent
Product of the present invention preferably includes flavoring agent, and it for example comprises, sweetener and/or aromatic oil.
The sweetener example that is fit to is saccharin salt (a particularly saccharin sodium), cyclamate (particularly encircling sodium sulfonate) and sucrose, lactose, maltose or fructose.
The aromatic oil that is fit to is all natural and synthetic perfumes that are used for oral cavity and dental hygiene product.Natural perfume material can be from medicinal herbs isolated essential oils form (mixture) and from medicinal herbs isolated single component form.Preferably have at least a aromatic oil, it is selected from Oleum menthae, spearmint, oleum anisi, Oleum Anisi Stellati, Herba Coriandri oil, Eucalyptus oil, Oleum Anisi Stellati, Oleum Cinnamomi, Oleum Caryophylli, Flos Pelargonii oil, Salvia Sclare L.oil, sweet green pepper tree oil, thyme oil, Majorana hortensis oil, basil oil, tangerine oil, white strain tree oil, from separate or these oily components of synthetic preparation one or more.The solvent of described oil for example is a menthol, carvone, anethole, cineol, acetaminol, cinnamic aldehyde, Flos Caryophylli alkene, geraniol, citronellol, linalool, salvene, thymol, terpinene, terpinol, estragole and cresotinic acid acid esters.Other spice that are fit to for example are acetic acid menthol ester, vanillin, ionoionone, linalyl acetate, rhodinol and menthone.
At last, also can there be usual auxiliaries, to improve the stability and the organoleptic properties of oral cavity and dental hygiene product.The example of auxiliary agent is:
Vitamin, vitamin A for example, biotin, vitamin E, vitamin C and its derivant (for example ester, salt);
Pigment, for example titanium dioxide or zinc oxide;
The coloring pigment particle, for example painted silicon oxide particle, as commercial can proprietary term Sorbosil
BFG 51, BFG 52 and BFG 53 or Sorbosil
2352 obtain those.Also can use the mixture of different coloring pigment particles.In product of the present invention, the amount of for example heavy Fructus Citri tangerinae color, redness or blue gel silicon oxide particle is 0.1-1.0wt.%;
Bleach, for example, hydrogen peroxide and hydrogen peroxide precursor;
Coloring agent;
PH-regulator and buffering material, sodium citrate for example, sodium bicarbonate or potassium bicarbonate and sodium phosphate;
Antiseptic, methyl for example, ethyl or propyl para-hydroxybenzoate, sodium sorbate, sodium benzoate, bromochlorobenzene or triclosan;
Wound healing and infection material, for example, allantoin, urea, panthenol, azulenes or Flos Chrysanthemi extract, acetyl salicylic acid derivatives, alkali metal thiocyanate;
Mineral salt is as zinc, magnesium and manganese salt, for example sulfate.
By the total restatement of product of the present invention, the about altogether 2～10wt.% of all these selectable toothpaste components.
A second aspect of the present invention is oral cavity of the present invention and the cosmetic use of dentistry Cleasing compositions in the sensitivity cleaning of tooth.
Cosmetic use is represented oral cavity of the present invention and the dentistry Cleasing compositions non-therapeutic use in every day cleaning and nursing tooth and oral cavity.
Responsive cleaning refers to owing to detergent contents is low teeth surfaces leniently.In this case, enamel and dentin can not be subjected to the attack of excessive cleaning agent abrasive action, can guarantee the deposition of remineralization component simultaneously.
A third aspect of the present invention is oral cavity of the present invention and the cosmetic use of dentistry Cleasing compositions in prevention and control hypersensitization tooth.
A fourth aspect of the present invention is oral cavity of the present invention and dental hygiene product at blast tooth and prevention variable color and the cosmetic use in the variable color again.
Use commercial availablely,, measure the blast degree of tooth by tooth of relatively handling with dentistry Cleasing compositions of the present invention and the tooth of handling with comparative formulations than toner (deriving from Lange).
A fifth aspect of the present invention is oral cavity of the present invention and dental hygiene product in the adhesion of pre-preventing dental plaque and reduces cosmetic use during new dental plaque forms on the dental surface.The dental plaque that can reduce like this on the dental surface adheres to.
A sixth aspect of the present invention is oral cavity of the present invention and the cosmetic use of dental hygiene product in the damage of remineralization dentistry.
By using suitable toothbrush can improve the effect of composite.By bristle arrangements of selecting to be fit to and the brush design that is fit to, especially brush and otch can make the dental hygiene product that contains composite have cleaning efficacy, and have high deposition property.
The suitable packing that comprises the dental hygiene preparation of composite of the present invention comprises pipe and allotter, and pump and other help the packing of dosage form.
The following examples are used for sets forth in detail theme of the present invention, rather than limit the invention.
Unless refer else, described consumption is wt.%.
Embodiment
1) embodiment of half stringing toothpaste preparation
| Neosorb 70/70 1 | 14.000 |
| Glycerol 86% is pure | 18.000 |
| Sipernat (FK)320DS 2 | 0.500 |
| Sident 8 3 | 5.000 |
| Magnesium sulfate | 1.400 |
| Saccharin sodium | 0.200 |
| Single fluoro sodium phosphate | 1.100 |
| The PHB methyl ester | 0.100 |
| Disodium hydrogen phosphate | 0.100 |
| Tertiary sodium phosphate | 0.050 |
| Nani in the glycerol dispersion 4 | 5.200 |
| Xanthan gum NF | 1.250 |
| 1, the 2-propylene glycol | 5.000 |
| Tego Betain BL215 5 | 0.600 |
| Texapon K12G 6 | 1.500 |
| Potassium nitrate | 5.000 |
| Spice | 1.000 |
| Water | 5.000 |
2) embodiment of low viscosity toothpaste preparation
| Neosorb 70/70 | 55.000 |
| Sident 8 | 5.000 |
| Disodium hydrogen phosphate | 0.200 |
| Sodium fluoride | 0.320 |
| Saccharin sodium | 0.200 |
| Sodium benzoate | 0.490 |
| Zinc sulfate-7H 2O | 0.088 |
| Titanium dioxide | 1.000 |
| Nanit in the glycerol dispersion | 5.200 |
| Polywachs 1550 7 | 1.000 |
| Keltrol F 8 | 0.500 |
| Texapon K1296 9 | 1.500 |
| Tegat S 10 | 0.500 |
| Tego Betain BL215 | 0.600 |
| NaOH | 0.316 |
| Ethanol | 2.000 |
| Spice | 1.200 |
| Water | Be added to 100 |
3) embodiment of viscosity (solid) toothpaste
| Neosorb 70/70 | 30.000 |
| Phosphoric acid 85% is pure | 0.050 |
| Sident 8 | 5.000 |
| Sident 22S11 | 8.000 |
| Sipernat(FK)320DS | 1.000 |
| Titanium dioxide | 1.000 |
| Nanit in the glycerol dispersion | 5.200 |
| Disodium hydrogen phosphate | 0.200 |
| Sodium fluoride | 0.320 |
| Saccharin sodium | 0.200 |
| NaOH | 0.158 |
| | 3.000 |
| Cekol 2000H 13 | 1.000 |
| Texapon K12 G | 1.350 |
| Spice | 1.000 |
| Water | Be added to 100 |
Experiment confirm, deposition keep the enough time, and have gentle especially cleaning efficacy.These experimental examples are as carrying out at the dentin sample, and analyze the growth of hydroxyapatite.
Commodity below using:
1 Neosorb
: INCI: Sorbitol; About 70% aqueous solution;
Manufacturer: Roquette
2 Sipernat
FK 320 DS:INCI: hydrated silica;
Manufacturer: Degussa
3 Sident
8:INCI: hydrated silica;
Manufacturer: Degussa
Nanit in the 4 glycerol dispersions: composite of the present invention, the last 10% dispersion in the glycerol
5 Tego Betain
BL215:INCI: cocoa amido propyl betaine; AS:30%
Manufacturer: Goldschmidt
6 Texapon
K12G:INCI: sodium lauryl sulfate; AS:95-99%
Manufacturer: Cognis
7 Polywachs
1550:INCI: Polyethylene Glycol; MW 1400-1600
Manufacturer: Sasol
8 Keltrol
F:INCI; Xanthan gum
Manufacturer: CP Kelco
9 Texapon
K1296: sodium lauryl sulfate; AS:90%
Manufacturer: Cognis
10 Tagat
S:INCI:PEG-30 glyceryl stearate
Manufacturer: Tego Cosmetics
11 Sident
22S:INCI: hydrated silica;
Manufacturer: Degussa
12 Polydiol
400:INCI: Polyethylene Glycol; MW 380-420
Manufacturer: Cognis
13 Cekol
2000H:INCI: cellulose gum
Manufacturer: Noviant
Claims (16)
1. oral cavity and dental hygiene product, it comprises
A) a kind of composite comprises
-calcium salt, it is slightly water-soluble one-level nanoparticle, length is 5～150nm, the cross section be 2～50nm and
-be selected from albumen, the protein component of hydrolyzed protein and hydrolyzed protein derivant and
B) press the total restatement of product, the cleaning agent of 0.1～9wt.%.
2. oral cavity as claimed in claim 1 and dental hygiene product is characterized in that described calcium salt is selected from fluoro apatite and/or hydroxyapatite.
3. as each described oral cavity and dental hygiene product in claim 1 or 2, it is characterized in that, described protein component is selected from structure and forms albumen, as collagen, gel, keratin, casein, wheat protein, rice protein, soybean protein, almond protein and its hydrolyzate and hydrolyzate derivant.
4. as each described oral cavity and dental hygiene product in the claim 1～3, it is characterized in that press the total restatement of product, the content of described composite is 0.01～10wt.%.
5. as each described oral cavity and dental hygiene product in the claim 1～4, it is characterized in that described one-level nanoparticle is bar-shaped.
6. as each described oral cavity and dental hygiene product in the claim 1～5, it is characterized in that it is 3 to≤5 that described one-level nanoparticle forms length-width ratio, particularly about 4 rhabdolith.
7. as each described oral cavity and dental hygiene product in the claim 1～6, it is characterized in that described cleaning agent is selected from silicon oxide, aluminium oxide, silicate, metaphosphate and alkaline earth metal carbonate or bicarbonate.
8. as each described oral cavity and dental hygiene product in the claim 1～7, it is characterized in that it comprises that at least a remineralization promotes component.
9. oral cavity as claimed in claim 8 and dental hygiene product is characterized in that, described remineralization promotes that component is selected from magnesium salt.
10. as each described oral cavity and dental hygiene product in the claim 1～9, it is characterized in that the active substance that it comprises surfactant, wetting agent, the binding agent as other toothpaste components and is used to prevent dentistry and gum disease.
11., it is characterized in that active substance is dental caries active substance, antibiotic substance, tartar inhibitor, prevent the active substance of hypersensitization tooth and/or the mixture of these materials as each described oral cavity and dental hygiene product in the claim 1～10.
12. as the cosmetic use in the sensitivity cleaning of tooth of each described oral cavity and dental hygiene product in the claim 1～11.
13. as the cosmetic use in prevention and control hypersensitization tooth of each described oral cavity and dental hygiene product in the claim 1～11.
14. as each described oral cavity and dental hygiene product in the claim 1～11 at blast tooth and prevention variable color and the cosmetic use in the variable color again.
15. as the cosmetic use in pre-preventing dental plaque adheres to of each described oral cavity and dental hygiene product in the claim 1～11.
16. as the cosmetic use in the damage of remineralization dentistry of each described oral cavity and dental hygiene product in the claim 1～11.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10340542.9 | 2003-09-01 | ||
| DE10340542A DE10340542A1 (en) | 2003-09-01 | 2003-09-01 | Mouth- and dental-care agent comprises a paste together with a composite material containing nanoparticulate difficultly water-soluble calcium salt and a protein or protein hydrolysate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1845719A true CN1845719A (en) | 2006-10-11 |
Family
ID=34202347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2004800250942A Pending CN1845719A (en) | 2003-09-01 | 2004-08-24 | Mouth- and dental-care agent |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20060222602A1 (en) |
| EP (1) | EP1660028A1 (en) |
| JP (1) | JP2007504186A (en) |
| CN (1) | CN1845719A (en) |
| BR (1) | BRPI0414018A (en) |
| CA (1) | CA2534963A1 (en) |
| DE (1) | DE10340542A1 (en) |
| WO (1) | WO2005027863A1 (en) |
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| CN105030557A (en) * | 2008-02-08 | 2015-11-11 | 高露洁-棕榄公司 | Oral care product and methods of use and manufacture thereof |
| CN107666895A (en) * | 2015-05-29 | 2018-02-06 | 高露洁-棕榄公司 | Foaming dentifrice with desensitizer |
| CN108601956A (en) * | 2015-10-26 | 2018-09-28 | 高露洁-棕榄公司 | Mouthrinse product and method |
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| RU2293551C1 (en) * | 2005-05-23 | 2007-02-20 | Ооо "Вдс" | Composition for mouth cavity disease prophylaxis |
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| DE102011082431A1 (en) * | 2011-09-09 | 2013-03-14 | Henkel Ag & Co. Kgaa | Special tooth cream for electric toothbrushes I |
| JP5957678B2 (en) * | 2012-02-07 | 2016-07-27 | 株式会社サンギ | Calcium phosphate dispersion composition |
| JP2015535262A (en) | 2012-11-05 | 2015-12-10 | ザ プロクター アンド ギャンブルカンパニー | Heat treated precipitated silica |
| DE102013004088A1 (en) | 2013-03-11 | 2014-09-11 | Voco Gmbh | Particularly storage-stable and thixotropic stable prophylaxis paste for professional dental use |
| DE102013109758B4 (en) † | 2013-09-06 | 2017-07-13 | Ferton Holding S.A. | Powder mixture, use of the powder mixture, powder blasting machine and method for remineralization of teeth |
| DE102013109848A1 (en) | 2013-09-09 | 2015-03-12 | Heraeus Kulzer Gmbh | Application system for simple, 3-dimensional application of medical, cosmetic or drug-containing dental care products |
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| JP6584114B2 (en) * | 2015-03-30 | 2019-10-02 | ニッタ・ハース株式会社 | Polishing composition |
| EP3600238B1 (en) * | 2017-04-24 | 2024-06-05 | Basf Se | Oral care products for treating white spot lesions |
| TW202202130A (en) * | 2020-03-30 | 2022-01-16 | 日商西尾股份有限公司 | Tooth whitening and tooth strengthening method |
| CN113197812A (en) * | 2021-06-17 | 2021-08-03 | 湖北仙之灵食品有限公司 | Production process of toothpaste with tooth cleaning, anti-inflammatory and bactericidal functions |
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| DE3114493A1 (en) * | 1981-04-10 | 1982-10-28 | Degussa Ag, 6000 Frankfurt | "FELLING SILICONES AND METHOD FOR THE PRODUCTION THEREOF" |
| US5302373A (en) * | 1993-06-10 | 1994-04-12 | Church & Dwight Co., Inc. | Liquid mouthwash containing a particulate bicarbonate suspension |
| DE19502168C1 (en) * | 1995-01-25 | 1996-06-27 | Henkel Kgaa | Process for the production of wheat protein hydrolyzates |
| KR100231550B1 (en) * | 1996-09-17 | 1999-11-15 | 류정열 | Transmission apparatus of an electric vehicle |
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| DK1023035T3 (en) * | 1997-10-17 | 2002-09-16 | Zakrytoe Aktsionernoe Obschest | The oral composition |
| DE19930335A1 (en) * | 1999-07-02 | 2001-01-18 | Henkel Kgaa | Composite materials made from calcium compounds and protein components |
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| DE20214694U1 (en) * | 2002-09-23 | 2004-02-19 | Sustech Gmbh & Co. Kg | chewing gum |
-
2003
- 2003-09-01 DE DE10340542A patent/DE10340542A1/en not_active Withdrawn
-
2004
- 2004-08-24 EP EP04764416A patent/EP1660028A1/en not_active Ceased
- 2004-08-24 CN CNA2004800250942A patent/CN1845719A/en active Pending
- 2004-08-24 CA CA002534963A patent/CA2534963A1/en not_active Abandoned
- 2004-08-24 WO PCT/EP2004/009437 patent/WO2005027863A1/en active Application Filing
- 2004-08-24 JP JP2006525072A patent/JP2007504186A/en not_active Withdrawn
- 2004-08-24 BR BRPI0414018-4A patent/BRPI0414018A/en not_active IP Right Cessation
-
2006
- 2006-03-01 US US11/365,380 patent/US20060222602A1/en not_active Abandoned
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030557A (en) * | 2008-02-08 | 2015-11-11 | 高露洁-棕榄公司 | Oral care product and methods of use and manufacture thereof |
| CN107666895A (en) * | 2015-05-29 | 2018-02-06 | 高露洁-棕榄公司 | Foaming dentifrice with desensitizer |
| CN108601956A (en) * | 2015-10-26 | 2018-09-28 | 高露洁-棕榄公司 | Mouthrinse product and method |
| CN108601720A (en) * | 2015-10-26 | 2018-09-28 | 高露洁-棕榄公司 | oral care product and method |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005027863A1 (en) | 2005-03-31 |
| BRPI0414018A (en) | 2006-10-24 |
| DE10340542A1 (en) | 2005-03-24 |
| US20060222602A1 (en) | 2006-10-05 |
| EP1660028A1 (en) | 2006-05-31 |
| JP2007504186A (en) | 2007-03-01 |
| CA2534963A1 (en) | 2005-03-31 |
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