CN1840051A - Pain-stopping gel with musk and its preparation method - Google Patents
Pain-stopping gel with musk and its preparation method Download PDFInfo
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- CN1840051A CN1840051A CNA2006100017277A CN200610001727A CN1840051A CN 1840051 A CN1840051 A CN 1840051A CN A2006100017277 A CNA2006100017277 A CN A2006100017277A CN 200610001727 A CN200610001727 A CN 200610001727A CN 1840051 A CN1840051 A CN 1840051A
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Abstract
The invention relates to pain-stopping gel with musk and its preparation method, wherein the gel is mainly prepared from musk, safflower, camphor, pubescent angelica root, boneol, dragon's blood and right amount of auxiliary materials.
Description
Technical field
The present invention relates to a kind of pain-stopping gel with musk and preparation method thereof, belong to technical field of Chinese medicine.
Technical background
Moschus dispel the pain liniment form by Moschus, Flos Carthami, Camphora, Radix Angelicae Pubescentis, Borneolum Syntheticum, Sanguis Draxonis, Mentholum, Radix Rehmanniae, Radix Notoginseng, effect with blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, reducing swelling and alleviating pain is used for various traumatic injury, swelling and pain due to blood stasis, the resistance of the rheumatism stasis of blood, diseases such as arthralgia, occuping market larger specific gravity always, clinical use, curative effect is sure, but because inconvenience is preserved, transports, used to liniment, and easy pollution clothes, easy cleaning does not cause this medicine limited to a certain extent; For this reason, develop a kind of determined curative effect, take, storage, convenient transportation, be easier to just to be seemed particularly important by the novel dosage form that extensive patients is accepted.Gel is one of most active in recent years medicine novel form, is the focus of local topical preparation research and development in recent years, has smooth in appearance, transparent exquisiteness; Nonirritant does not hinder the normal function of skin; Denseness, viscosity suit, and are easy to coating and use, and it is very convenient to carry, use, preserve, transport, advantages such as good stability.For this reason, a kind of novel gel has been developed in the character of inventor's bound drug itself and the characteristics of surgery local application and the modern requirement of Chinese medicine preparation.By retrieval, this gel still belongs to internal blank.
Summary of the invention
The object of the present invention is to provide a kind of new pharmaceutical preparation and preparation method thereof, this invention preparation mainly adds proper auxiliary materials by Moschus, Flos Carthami, Camphora, Radix Angelicae Pubescentis, Borneolum Syntheticum, Sanguis Draxonis, Mentholum, Radix Rehmanniae, Radix Notoginseng and is prepared from, effect with blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, reducing swelling and alleviating pain, be used for various traumatic injury, swelling and pain due to blood stasis, the resistance of the rheumatism stasis of blood, arthralgia.This medicine is through clinical use, determined curative effect, and nontoxic, side effect.Gel of the present invention is applied in the affected part; no greasy feeling; good with the skin coupling; good absorbing; and can form the very thin protecting film of one deck at pars affecta skin after smearing, have protection and wetting action, and carry, store, transport all more convenient; stability improves greatly simultaneously, and then has obviously improved the curative effect of medicine and patient's facility.
The present invention is achieved through the following technical solutions:
A kind of pain-stopping gel with musk, it is characterized in that, calculate by weight, it is mainly by the Moschus pain impregnation liquid 5-17.5 part of dispelling, Borneolum Syntheticum 1-3 part, Camphora 2-4 part, Mentholum 0.5-1.5 part, substrate 0.1-10 part, wetting agent 2-15 part, antiseptic 0-0.5 part, solvent 48.5-89.4 part are prepared from.Preferred scheme is: calculate by weight, it is mainly by the Moschus pain impregnation liquid 10-15 part of dispelling, 2 parts of Borneolum Syntheticums, and 3 parts of Camphoras, 1 part of Mentholum, substrate 2-8 part, wetting agent 3-10 part, antiseptic 0.2-0.5 part, solvent 60.5-78.8 part are prepared from.Moschus is dispelled bitterly, and impregnation liquid is mainly to be prepared from for 1 part by 0.33 part in Moschus, 0.33 part of Radix Notoginseng, 1 part on Flos Carthami, 20 parts of Radix Rehmanniae, 0.33 part of Sanguis Draxonis, Radix Angelicae Pubescentis.Substrate comprises one or more in sodium alginate, xanthan gum, guar gum, tragcanth, arabic gum, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, polyacrylamide, cross linked sodium polyacrylate, Polyethylene Glycol, the carbomer; Wetting agent comprises one or both in glycerol, the propylene glycol; Antiseptic comprises one or more in sorbic acid, potassium sorbate, ethyl hydroxybenzoate, benzyl alcohol, the thimerosal; Solvent comprises one or more in water, the Different concentrations of alcohol.Preferred gel-type vehicle is one or both of carbomer, sodium carboxymethyl cellulose; Wetting agent is a glycerol.
Pain-stopping gel with musk is preparation like this:
(1) calculate by weight, raw material of the present invention consists of: 0.33 part in Moschus, 1 part on Flos Carthami, 30 parts of Camphoras, 1 part of Radix Angelicae Pubescentis, 20 parts of Borneolum Syntheticums, 0.33 part of Sanguis Draxonis, 10 parts of Mentholums, 20 parts of Radix Rehmanniae, 0.33 part of Radix Notoginseng;
(2) Moschus, Radix Notoginseng, Flos Carthami divide dipping three times with 50% ethanol 10ml respectively, and each 7 days, merge impregnation liquid, filter filtrate for later use; Radix Rehmanniae is divided dipping three times with 50% ethanol 100ml, and each 7 days, merge impregnation liquid, filter filtrate for later use; Sanguis Draxonis, Radix Angelicae Pubescentis divide dipping three times with ethanol 10ml respectively, and each 7 days, merge impregnation liquid, filter filtrate for later use; Borneolum Syntheticum, Camphora add ethanol 100ml stirring makes dissolving, adds 50% ethanol 700ml again, and mixing adds above-mentioned each impregnation liquid, mixing; Mentholum with an amount of 50% dissolve with ethanol, is added in the above-mentioned medicinal liquid, add gel-type vehicle, wetting agent, antiseptic, stir and make dissolving, add solvent, stir, make gel, promptly to full dose.
At prior art, Moschus dispel the pain liniment carry, transport, preserve extremely inconvenient, easy pollution clothes, not drawback such as easy cleaning; Novel gel has been developed in the characteristics of bound drug character of the present invention and medicine for external use and the modern requirement of Chinese medicine preparation.The present invention carries out preferably adjuvants such as gel-type vehicle, wetting agents through a large amount of experiments, to the consumption of its adjuvant and and the relevant nature that is used of medicine carried out systematic research.The gel smooth in appearance that the present invention makes, transparent exquisiteness; No greasy feeling, pollution clothes not, easy cleaning; Be applied in the affected part, good with the skin coupling, good absorbing, and, have protection and humidification at skin surface formation protecting film, and the part is non-stimulated, does not hinder the normal function of skin, and it is very convenient to preserve, transport, carry.
The inventor finds that in development process kind, the consumption of adjuvant have considerable influence to it, and for this reason, the applicant has carried out a series of experiments, to prove beneficial effect of the present invention.
The experimental example Study on Forming
1, the gel-type vehicle kind is selected
Gel has the branch of aqueous gel and oil-base gel, and aqueous gel is because of its excellent biological compatibility, adhesiveness, no greasy feeling, and easy cleaning, pollution clothes is used more in the external dosage form.The aqueous gel adjuvant has natural polymer subclass such as xanthan gum, guar gum, arabic gum etc., cellulose derivative such as hydroxypropyl methylcellulose (HPMC), sodium carboxymethyl cellulose (CMC-Na), synthetic macromolecular compound carbomer etc.
Test method: the substrate with above-mentioned usual amounts adds respectively in the impregnation liquid earlier, stirs, and the results are shown in Table 1.
Table 1 gel-type vehicle kind is preferably shown
| Supplementary product kind | Consumption (%) | The result |
| HPMC carbomer CMC-Na xanthans guar gum Arabic gum sodium alginate tragcanth polyacrylamide cross linked sodium polyacrylate polyethylene glycol | 0.9 0.4 1.0 1.0 1.0 5 5 5 2 2 4 | Make even gel, clarity is better, does not have precipitation and separates out.Make even gel, clarity is good, does not have precipitation and separates out.Make even gel, do not have precipitation and separate out.Make even gel, do not have precipitation and separate out.Make even gel, do not have precipitation and separate out.Make even gel, do not have precipitation and separate out.Make even gel, do not have precipitation and separate out.Make even gel, do not have precipitation and separate out.Make even gel, do not have precipitation and separate out.Make even gel, do not have precipitation and separate out.Make even gel, do not have precipitation and separate out. |
Table 1 shows, above-mentioned most adjuvant all can satisfy the preparation requirement substantially, the adjuvant of above usual amounts can both make even gel when wherein any one and/or all the other one or more adjuvants are used, but be that the every index of gel made of substrate is all more satisfactory with carbomer or HPMC especially, so preferred carbomer or HPMC are as gel-type vehicle.
2, substrates quantity screening
Carbomer is an acrylic copolymer with macromolecule, is great swelling state after aqueous dispersion is neutralized, and by thickening, consumption seldom in gel; In order to make the gel that viscosity is moderate, be fit to external, the carbomer consumption is screened.
Carbomer that will be not commensurability adds in the percolate respectively, stirs result such as table 2.
Table 2 carbomer consumption is preferably shown
| Consumption (part) | The result |
| 0.1 0.5 1.0 2.0 5.0 8.0 10.0 | It is rarer to make gel, can smear and make the gel stickiness and be fit to, more easily smear and make the gel stickiness and be fit to, more easily smear and make the gel stickiness and be fit to, easily smear and make the gel stickiness and be fit to, easily smear and make the gel stickiness and be fit to, smear easily that to make gel more sticky, can smear |
According to table 2 result, the consumption of carbomer all can satisfy the preparation requirement substantially 0.1-10 part, but experiment finds that carbomer consumption obtained gel when 2-8 part is better.
3, the glycerol consumption is investigated
In order to keep moisture preserving time and the comfortableness of gel on skin, the assurance drug absorption is complete, generally to add wetting agent, wetting agent commonly used has glycerol, propylene glycol etc., through trial test, uses glycerol or propylene glycol or the two mixture and all can play moisture-keeping function, and glycerol can dissolve carbomer, and in gel rubber system, do not influence the dissolubility of ingredient and other adjuvant, therefore select for use glycerol, and consumption is screened as wetting agent.
Get transparent paraffin paper and be cut into a certain size, weigh again after evenly coating layer of gel after precision is weighed, place respectively at about 25 ℃ and 37 ℃ and take out after 8 hours, weigh, determine the water evaporates situation; The results are shown in Table 3.
Table 3 glycerol consumption is preferably shown
| Glycerol consumption (part) | 25℃ | 37℃ |
| 2 3 5 7 10 13 15 | Loss of weight 2.8% loss of weight 1.5% loss of weight 1.1% loss of weight 1.0% loss of weight 0.8% loss of weight 1.7% loss of weight 2.4% | Loss of weight 3.5% loss of weight 1.7% loss of weight 1.3% loss of weight 1.1% loss of weight 0.7% loss of weight 2.0% loss of weight 2.8% |
As shown in Table 7, the glycerol consumption can play the moisturizing effect substantially between 2～15 parts, and consumption can play moisture-keeping function preferably when 3-10 part.
Concrete embodiment
Embodiment 1: Moschus 0.33g, Flos Carthami 1g, Camphora 30g, Radix Angelicae Pubescentis 1g, Borneolum Syntheticum 20g, Sanguis Draxonis 0.33g, Mentholum 10g, Radix Rehmanniae 20g, Radix Notoginseng 0.33g
Get Moschus, Radix Notoginseng, Flos Carthami, divide dipping three times with 50% ethanol 10ml respectively, each 7 days, merge impregnation liquid, filter filtrate for later use; Radix Rehmanniae is divided dipping three times with 50% ethanol 100ml, and each 7 days, merge impregnation liquid, filter filtrate for later use; Sanguis Draxonis, Radix Angelicae Pubescentis divide dipping three times with ethanol 10ml respectively, and each 7 days, merge impregnation liquid, filter filtrate for later use; Borneolum Syntheticum, Camphora add ethanol 100ml stirring makes dissolving, adds 50% ethanol 700ml again, and mixing nearly weighs 720g, adds above-mentioned each impregnation liquid, nearly weighs 120g, mixing; Mentholum with an amount of 50% dissolve with ethanol, is nearly weighed 12g, and other gets carbomer 40g, glycerol 80g and 50% ethanol 28g, and mixing adds above-mentioned solution, stirs, and places, and makes abundant swelling, makes gel 1000g, promptly.
Embodiment 2: Moschus 0.33g, Flos Carthami 1g, Camphora 30g, Radix Angelicae Pubescentis 1g, Borneolum Syntheticum 20g, Sanguis Draxonis 0.33g, Mentholum 10g, Radix Rehmanniae 20g, Radix Notoginseng 0.33g
Get Moschus, Radix Notoginseng, Flos Carthami, divide dipping three times with 50% ethanol 10ml respectively, each 7 days, merge impregnation liquid, filter filtrate for later use; Radix Rehmanniae is divided dipping three times with 50% ethanol 100ml, and each 7 days, merge impregnation liquid, filter filtrate for later use; Sanguis Draxonis, Radix Angelicae Pubescentis divide dipping three times with ethanol 10ml respectively, and each 7 days, merge impregnation liquid, filter filtrate for later use; Borneolum Syntheticum, Camphora add ethanol 100ml stirring makes dissolving, adds 50% ethanol 700ml again, and mixing nearly weighs 700g, adds above-mentioned each impregnation liquid, nearly weighs 160g, mixing; Mentholum with an amount of 50% dissolve with ethanol, is nearly weighed 13g, and other gets HPMC20g, propylene glycol 100g, sorbic acid 5g and 75% ethanol 2g mixing, adds above-mentioned solution, stirs, and places, and makes abundant swelling, makes gel 1000g, promptly.
Embodiment 3: Moschus 0.33g, Flos Carthami 1g, Camphora 30g, Radix Angelicae Pubescentis 1g, Borneolum Syntheticum 20g, Sanguis Draxonis 0.33g, Mentholum 10g, Radix Rehmanniae 20g, Radix Notoginseng 0.33g
Get Moschus, Radix Notoginseng, Flos Carthami, divide dipping three times with 50% ethanol 10ml respectively, each 7 days, merge impregnation liquid, filter filtrate for later use; Radix Rehmanniae is divided dipping three times with 50% ethanol 100ml, and each 7 days, merge impregnation liquid, filter filtrate for later use; Sanguis Draxonis, Radix Angelicae Pubescentis divide dipping three times with ethanol 10ml respectively, and each 7 days, merge impregnation liquid, filter filtrate for later use; Borneolum Syntheticum, Camphora add ethanol 100ml stirring makes dissolving, adds 50% ethanol 700ml again, and mixing nearly weighs 710g, adds above-mentioned each impregnation liquid, nearly weighs 50g, mixing; With Mentholum with an amount of 50% dissolve with ethanol, nearly weigh 15g, other gets polyacrylamide 40g, cross linked sodium polyacrylate 40g, glycerol 50g, propylene glycol 60g, ethyl hydroxybenzoate 2g and 80% ethanol 33g mixing, add above-mentioned solution, stir, place, make abundant swelling, make gel 1000g, promptly.
Embodiment 4: Moschus 0.33g, Flos Carthami 1g, Camphora 30g, Radix Angelicae Pubescentis 1g, Borneolum Syntheticum 20g, Sanguis Draxonis 0.33g, Mentholum 10g, Radix Rehmanniae 20g, Radix Notoginseng 0.33g
Get Moschus, Radix Notoginseng, Flos Carthami, divide dipping three times with 50% ethanol 10ml respectively, each 7 days, merge impregnation liquid, filter filtrate for later use; Radix Rehmanniae is divided dipping three times with 50% ethanol 100ml, and each 7 days, merge impregnation liquid, filter filtrate for later use; Sanguis Draxonis, Radix Angelicae Pubescentis divide dipping three times with ethanol 10ml respectively, and each 7 days, merge impregnation liquid, filter filtrate for later use; Borneolum Syntheticum, Camphora add ethanol 100ml stirring makes dissolving, adds 50% ethanol 700ml again, and mixing nearly weighs 710g, adds above-mentioned each impregnation liquid, nearly weighs 175g, mixing; With Mentholum with an amount of 50% dissolve with ethanol, nearly weigh 10.5g, other gets hydroxypropyl methylcellulose 10g, sodium carboxymethyl cellulose 20g, glycerol 20g, benzyl alcohol 0.5g, thimerosal 1.0g and 50% ethanol 53.0g mixing, add above-mentioned solution, stir, place, make abundant swelling, make gel 1000g, promptly.
Embodiment 5: Moschus 0.33g, Flos Carthami 1g, Camphora 30g, Radix Angelicae Pubescentis 1g, Borneolum Syntheticum 20g, Sanguis Draxonis 0.33g, Mentholum 10g, Radix Rehmanniae 20g, Radix Notoginseng 0.33g
Get Moschus, Radix Notoginseng, Flos Carthami, divide dipping three times with 50% ethanol 10ml respectively, each 7 days, merge impregnation liquid, filter filtrate for later use; Radix Rehmanniae is divided dipping three times with 50% ethanol 100ml, and each 7 days, merge impregnation liquid, filter filtrate for later use; Sanguis Draxonis, Radix Angelicae Pubescentis divide dipping three times with ethanol 10ml respectively, and each 7 days, merge impregnation liquid, filter filtrate for later use; Borneolum Syntheticum, Camphora add ethanol 100ml stirring makes dissolving, adds 50% ethanol 700ml again, and mixing nearly weighs 705g, adds above-mentioned each impregnation liquid, nearly weighs 150g, mixing; Mentholum with an amount of 50% dissolve with ethanol, is nearly weighed 13.5g, and other gets xanthan gum 20g, guar gum 20g, tragcanth 20g, propylene glycol 10g, glycerol 20g and distilled water 41.5g mixing, add above-mentioned solution, stir, place, make abundant swelling, make gel 1000g, promptly.
Embodiment 6: Moschus 0.33g, Flos Carthami 1g, Camphora 30g, Radix Angelicae Pubescentis 1g, Borneolum Syntheticum 20g, Sanguis Draxonis 0.33g, Mentholum 10g, Radix Rehmanniae 20g, Radix Notoginseng 0.33g
Get Moschus, Radix Notoginseng, Flos Carthami, divide dipping three times with 50% ethanol 10ml respectively, each 7 days, merge impregnation liquid, filter filtrate for later use; Radix Rehmanniae is divided dipping three times with 50% ethanol 100ml, and each 7 days, merge impregnation liquid, filter filtrate for later use; Sanguis Draxonis, Radix Angelicae Pubescentis divide dipping three times with ethanol 10ml respectively, and each 7 days, merge impregnation liquid, filter filtrate for later use; Borneolum Syntheticum, Camphora add ethanol 100ml stirring makes dissolving, adds 50% ethanol 700ml again, and mixing nearly weighs 711g, adds above-mentioned each impregnation liquid, nearly weighs 100g, mixing; Mentholum with an amount of 50% dissolve with ethanol, is nearly weighed 12.5g, in addition taking polyethylene glycol 30g, hydroxypropyl methylcellulose 50g, propylene glycol 40g, potassium sorbate 2g and 70% ethanol 54.5g mixing, add above-mentioned solution, stir, place, make abundant swelling, make gel 1000g, promptly.
Embodiment 7: Moschus 0.33g, Flos Carthami 1g, Camphora 30g, Radix Angelicae Pubescentis 1g, Borneolum Syntheticum 20g, Sanguis Draxonis 0.33g, Mentholum 10g, Radix Rehmanniae 20g, Radix Notoginseng 0.33g
Get Moschus, Radix Notoginseng, Flos Carthami, divide dipping three times with 50% ethanol 10ml respectively, each 7 days, merge impregnation liquid, filter filtrate for later use; Radix Rehmanniae is divided dipping three times with 50% ethanol 100ml, and each 7 days, merge impregnation liquid, filter filtrate for later use; Sanguis Draxonis, Radix Angelicae Pubescentis divide dipping three times with ethanol 10ml respectively, and each 7 days, merge impregnation liquid, filter filtrate for later use; Borneolum Syntheticum, Camphora add ethanol 100ml stirring makes dissolving, adds 50% ethanol 700ml again, and mixing nearly weighs 730g, adds above-mentioned each impregnation liquid, nearly weighs 125g, mixing; Mentholum with an amount of 50% dissolve with ethanol, is nearly weighed 11.5g, and other gets carbomer 30g, hydroxypropyl methylcellulose 30g, glycerol 60g, nipalgin 3g and 65% ethanol 10.5g mixing, add above-mentioned solution, stir, place, make abundant swelling, make gel 1000g, promptly.
Embodiment 8: Moschus 0.33g, Flos Carthami 1g, Camphora 30g, Radix Angelicae Pubescentis 1g, Borneolum Syntheticum 20g, Sanguis Draxonis 0.33g, Mentholum 10g, Radix Rehmanniae 20g, Radix Notoginseng 0.33g
Get Moschus, Radix Notoginseng, Flos Carthami, divide dipping three times with 50% ethanol 10ml respectively, each 7 days, merge impregnation liquid, filter filtrate for later use; Radix Rehmanniae is divided dipping three times with 50% ethanol 100ml, and each 7 days, merge impregnation liquid, filter filtrate for later use; Sanguis Draxonis, Radix Angelicae Pubescentis divide dipping three times with ethanol 10ml respectively, and each 7 days, merge impregnation liquid, filter filtrate for later use; Borneolum Syntheticum, Camphora add ethanol 100ml stirring makes dissolving, adds 50% ethanol 700ml again, and mixing nearly weighs 731g, adds above-mentioned each impregnation liquid, nearly weighs 145g, mixing; With Mentholum with an amount of 50% dissolve with ethanol, nearly weigh 15.2g, other gets cross linked sodium polyacrylate 10g, hydroxypropyl methylcellulose 30g, propylene glycol 50g, ethyl hydroxybenzoate 2g, benzyl alcohol 2g and 85% ethanol 14.8g mixing, add above-mentioned solution, stir, place, make abundant swelling, make gel 1000g, promptly.
Claims (6)
1, a kind of pain-stopping gel with musk is characterized in that, calculates by weight, it is mainly by the Moschus pain impregnation liquid 5-17.5 part of dispelling, 2 parts of Borneolum Syntheticums, 3 parts of Camphoras, 1 part of Mentholum, substrate 0.1-10 part, wetting agent 2-15 part, antiseptic 0-0.5 part, solvent 48.5-89.4 part are prepared from.
2, a kind of pain-stopping gel with musk is characterized in that, calculates by weight, and it is mainly by the Moschus pain impregnation liquid 10-15 part of dispelling, 2 parts of Borneolum Syntheticums, and 3 parts of Camphoras, 1 part of Mentholum, substrate 2-8 part, wetting agent 3-10 part, solvent 61-79 part are prepared from.
3, according to claim 1,2 described a kind of pain-stopping gel with musk, it is characterized in that, calculating by weight, Moschus are dispelled bitterly, and impregnation liquid is mainly to be prepared from for 1 part by 0.33 part in Moschus, 0.33 part of Radix Notoginseng, 1 part on Flos Carthami, 20 parts of Radix Rehmanniae, 0.33 part of Sanguis Draxonis, Radix Angelicae Pubescentis.
4, according to claim 1,2 described a kind of pain-stopping gel with musk, it is characterized in that substrate comprises one or more in sodium alginate, xanthan gum, guar gum, tragcanth, arabic gum, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, polyacrylamide, cross linked sodium polyacrylate, Polyethylene Glycol, the carbomer; Wetting agent comprises one or both in glycerol, the propylene glycol; Antiseptic comprises one or more in sorbic acid, potassium sorbate, ethyl hydroxybenzoate, benzyl alcohol, the thimerosal; Solvent comprises one or more in water, the Different concentrations of alcohol.
5, a kind of pain-stopping gel with musk according to claim 4 is characterized in that: gel-type vehicle is meant one or both of carbomer, the interior methylcellulose of hydroxyl; Wetting agent is meant glycerol.
According to the preparation method of any described a kind of pain-stopping gel with musk among the claim 1-5, it is characterized in that 6, gel is preparation like this:
(1) calculate by weight, raw material of the present invention consists of: 0.33 part in Moschus, 1 part on Flos Carthami, 30 parts of Camphoras, 1 part of Radix Angelicae Pubescentis, 20 parts of Borneolum Syntheticums, 0.33 part of Sanguis Draxonis, 10 parts of Mentholums, 20 parts of Radix Rehmanniae, 0.33 part of Radix Notoginseng;
(2) Moschus, Radix Notoginseng, Flos Carthami divide dipping three times with 50% ethanol 10ml respectively, and each 7 days, merge impregnation liquid, filter filtrate for later use; Radix Rehmanniae is divided dipping three times with 50% ethanol 100ml, and each 7 days, merge impregnation liquid, filter filtrate for later use; Sanguis Draxonis, Radix Angelicae Pubescentis divide dipping three times with ethanol 10ml respectively, and each 7 days, merge impregnation liquid, filter filtrate for later use; Borneolum Syntheticum, Camphora add ethanol 100ml stirring makes dissolving, adds 50% ethanol 700ml again, and mixing adds above-mentioned each impregnation liquid, mixing; Mentholum with an amount of 50% dissolve with ethanol, is added in the above-mentioned medicinal liquid, add gel-type vehicle, wetting agent, antiseptic, stir and make dissolving, add solvent, stir, make gel, promptly to full dose.
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| CN104042848A (en) * | 2014-05-21 | 2014-09-17 | 丽珠医药集团股份有限公司 | Novel musk Shuhuoling |
| CN104435563A (en) * | 2014-10-26 | 2015-03-25 | 四川光大制药有限公司 | Preparation method of musk gel capable of promoting blood circulation to remove blood stasis, relieving swelling and pain and relaxing tendons and activating collaterals |
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| CN104042848A (en) * | 2014-05-21 | 2014-09-17 | 丽珠医药集团股份有限公司 | Novel musk Shuhuoling |
| CN104042848B (en) * | 2014-05-21 | 2017-09-12 | 丽珠医药集团股份有限公司 | New MUSK SHUHUOLING |
| CN104435563A (en) * | 2014-10-26 | 2015-03-25 | 四川光大制药有限公司 | Preparation method of musk gel capable of promoting blood circulation to remove blood stasis, relieving swelling and pain and relaxing tendons and activating collaterals |
| CN104435563B (en) * | 2014-10-26 | 2018-01-26 | 四川光大制药有限公司 | A kind of preparation method of MUSK SHUHUOLING gel |
| CN107252456A (en) * | 2017-06-09 | 2017-10-17 | 成都珂萝瑞诗化妆品有限公司 | A kind of swelling reducing and pain easing gel and preparation method thereof |
| US20230110830A1 (en) * | 2018-04-09 | 2023-04-13 | Ellevet Sciences | Hemp extract for treatment of pain in animals |
| CN111494590A (en) * | 2020-04-20 | 2020-08-07 | 佰氏健康(广州)大健康科技有限公司 | External spray for dispelling wind, relieving pain, dredging channels and activating collaterals, and stopping bleeding and diminishing swelling |
| CN114681552A (en) * | 2022-04-15 | 2022-07-01 | 李时珍医药集团有限公司 | Musk pain-relieving cataplasm and preparation method thereof |
| CN114681552B (en) * | 2022-04-15 | 2024-02-09 | 李时珍医药集团有限公司 | Musk pain-relieving cataplasm and preparation method thereof |
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| CN1840051B (en) | 2013-08-28 |
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Address after: 102200 Beijing Changping District science and Technology Park, 79 battalion road 79, cloud Valley 24, 5 floor, 508 rooms. Patentee after: Beijing Ying Kerui Biological Medicine Research Co Ltd Address before: 100088 Beijing city Xicheng District, New Street No. 2 Tiancheng Technology building block B room 3003 Patentee before: Beijing Yinkeruisi Biological Products Research Institute |