CN104042848A - Novel musk Shuhuoling - Google Patents
Novel musk Shuhuoling Download PDFInfo
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- CN104042848A CN104042848A CN201410222568.8A CN201410222568A CN104042848A CN 104042848 A CN104042848 A CN 104042848A CN 201410222568 A CN201410222568 A CN 201410222568A CN 104042848 A CN104042848 A CN 104042848A
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- aconiti lateralis
- lateralis preparata
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Abstract
The musk Shuhuoling prepared by the invention abridges the original prescription, and adjusts the amount of each drug, so as to realize similar effect by using 5 traditional Chinese medicines; and monkshood is used to substitute pseudo-ginseng, and reasonable utilization of pseudo-ginseng resource is explored, so as to facilitate the reduction of pharmaceutical cost.
Description
Technical field
The present invention relates to medicine and preparation method thereof, particularly relate to a kind of new MUSK SHUHUOLING and preparation method thereof.
Background technology
MUSK SHUHUOLING is comprised of 8 taste medicines.For athletic injury, acute and chronic soft tissue injury; The arthralgia of fracturing and swelling and ache and dislocating after healing, rheumatalgia.In side, the pungent loose temperature of Moschus is logical, and gas perfume (or spice) is walked to alter, and is good at promoting blood circulation to remove blood stasis, and dispersing swelling and dissipating binds pain relieving is the principal agent in side.Be aided with Radix Notoginseng, Sanguis Draxonis, Flos Carthami promoting blood circulation to remove blood stasis, subduing swelling and relieving pain; Camphora warming and odynolysis; Borneolum Syntheticum, the pain relieving of Mentholum clearing heat for detumescence.Assistant is subsided a swelling with Radix Rehmanniae clearing away heat and cooling blood.All medicines share, and play altogether promoting blood circulation to remove blood stasis, the merit of reducing swelling and alleviating pain.
The exclusive kind that MUSK SHUHUOLING Sichuan is wide, fills a prescription for country maintains secrecy.The Chinese crude drug using in MUSK SHUHUOLING is 8 tastes nearly, and mark is criticized respectively and concocted, and complex process, in order to shorten production process, the invention provides a kind of new MUSK SHUHUOLING.
Summary of the invention
The object of the invention is to provide a kind of new MUSK SHUHUOLING.
A MUSK SHUHUOLING, is characterized in that, its composition raw material comprises Moschus, Radix Aconiti Lateralis Preparata, Flos Carthami, Sanguis Draxonis and Radix Rehmanniae;
The ingredient proportion of described Moschus, Flos Carthami, Sanguis Draxonis and Radix Rehmanniae is 1: 30-50: 30-50: 120-200;
The inventory of described Radix Aconiti Lateralis Preparata is in Radix Notoginseng total arasaponins amount, and the ingredient proportion of described Radix Notoginseng total arasaponins amount and Moschus is 3-6: 1.
Described new MUSK SHUHUOLING, is characterized in that in order to below legal system standby: (1) Radix Aconiti Lateralis Preparata adds alcohol reflux, filters extracting solution, reclaims the ethanol in filtrate and is concentrated in right amount, dry, makes Radix Aconiti Lateralis Preparata dried cream powder; (2) Moschus is dissolved in ethanol; (3) Sanguis Draxonis, Flos Carthami, take Radix Aconiti Lateralis Preparata dried cream powder in appropriate step (1), by soak with ethanol; (4) Radix Rehmanniae soak with ethanol; (5) get the medical material soak in step (2)-(4), mix, obtain MUSK SHUHUOLING.
Described new MUSK SHUHUOLING is standby in order to below legal system: (1) Radix Aconiti Lateralis Preparata adds alcohol reflux, filters extracting solution, reclaims the ethanol in filtrate and is concentrated into appropriate, standby; (2) medicinal residues add alcohol reflux, extracting liquid filtering, and filtrate recycling ethanol is also concentrated into appropriate, standby; (3) medicinal residues add water backflow, and decocting liquid filters, and filtrate is concentrated in right amount; Merge said extracted concentrated solution, dry, make Radix Aconiti Lateralis Preparata dried cream powder; (4) Moschus is dissolved in ethanol; (5) Sanguis Draxonis, Flos Carthami, take Radix Aconiti Lateralis Preparata dried cream powder in appropriate step (3), by soak with ethanol; (6) Radix Rehmanniae soak with ethanol; (7) medical material in step (4)-(6) soaked after 10-45 days, got the medical material soak in step (2)-(5), obtained MUSK SHUHUOLING.
Described new MUSK SHUHUOLING is standby in order to below legal system: (1) Radix Aconiti Lateralis Preparata adds alcohol reflux 1.5 hours, filters extracting solution, reclaims the ethanol in filtrate and is concentrated into appropriate, standby; (2) medicinal residues add alcohol reflux 1.5 hours, extracting liquid filtering, and filtrate recycling ethanol is also concentrated into appropriate, standby; (3) medicinal residues add water backflow 2 hours, and decocting liquid filters, and filtrate is concentrated in right amount; Merge said extracted concentrated solution, dry, make Radix Aconiti Lateralis Preparata dried cream powder; (4) Moschus is dissolved in 75% ethanol; (5) Sanguis Draxonis, Flos Carthami, take Radix Aconiti Lateralis Preparata dried cream powder in appropriate step (3), use 98% soak with ethanol; (6) Radix Rehmanniae 98% soak with ethanol; (7) medical material in step (4)-(6) soaked after 10-45 days, got the medical material soak in step (2)-(5), according to 1: 1: 1 ratio, mixed, and obtained MUSK SHUHUOLING.
Described MUSK SHUHUOLING, is characterized in that comprising the medical material of clearing heat for detumescence pain relieving, and the medical material of described clearing heat for detumescence pain relieving is selected from one or more in Borneolum Syntheticum, Herba Menthae, Camphora, Rhizoma Cyperi, Rhizoma Chuanxiong, Radix Angelicae Sinensis.
Described MUSK SHUHUOLING, is characterized in that comprising antibiotic, described antibiotic is selected from one or more in Roxithromycin, gentamycin, clarithromycin.
MUSK SHUHUOLING prepared by the present invention, deletes original prescription, and adjusts for every kind of medicine use amount, finally realizes and uses 5 kinds of Chinese medicine ingredients to reach similar curative effect; And with Radix Aconiti Lateralis Preparata, replace Radix Notoginseng, for more reasonably utilizing Radix Notoginseng resource to explore, be conducive to reduce the cost of pharmacy.
The specific embodiment
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1:
(1) Radix Aconiti Lateralis Preparata adds alcohol reflux 1.5 hours, filters extracting solution, reclaims the ethanol in filtrate and is concentrated into appropriate, standby;
(2) medicinal residues add 50% alcohol reflux 1.5 hours, extracting liquid filtering, and filtrate recycling ethanol is also concentrated into appropriate, standby;
(3) medicinal residues add water backflow 2 hours, and decocting liquid filters, and filtrate is concentrated in right amount; Merge said extracted concentrated solution, dry, make Radix Aconiti Lateralis Preparata dried cream powder;
It is fragrant that (4) 75% ethanol 250ml dissolve 1g Moschus moschiferous;
(5) 30g Sanguis Draxonis, 30g Flos Carthami, take Radix Aconiti Lateralis Preparata dried cream powder (in Radix Notoginseng total arasaponins 4g) in appropriate step (3), with 98%7 alcohol 500ml immersions;
(6) 150g Radix Rehmanniae 98%7 alcohol soak;
(7) medical material in step (4)-(6) soaked after 10 days, according to 1: 1: 1 ratio, mixed, and obtained MUSK SHUHUOLING.
Embodiment 2:
(1) Radix Aconiti Lateralis Preparata adds alcohol reflux 1.5 hours, filters extracting solution, reclaims the ethanol in filtrate and is concentrated into appropriate, standby;
(2) medicinal residues add 50% alcohol reflux 1.5 hours, extracting liquid filtering, and filtrate recycling ethanol is also concentrated into appropriate, standby;
(3) medicinal residues add water backflow 2 hours, and decocting liquid filters, and filtrate is concentrated in right amount; Merge said extracted concentrated solution, dry, make Radix Aconiti Lateralis Preparata dried cream powder;
It is fragrant that (4) 75% ethanol 250ml dissolve 1g Moschus moschiferous;
(5) 50g Sanguis Draxonis, 50g Flos Carthami, take Radix Aconiti Lateralis Preparata dried cream powder (in Radix Notoginseng total arasaponins 3g) in appropriate step (3), with 98% ethanol 500ml immersion;
(6) 120g Radix Rehmanniae 98%7 alcohol soak;
(7) medical material in step (4)-(6) soaked after 40 days, according to 1: 1: 1 ratio, mixed, and obtained MUSK SHUHUOLING.
Embodiment 3:
(1) Radix Aconiti Lateralis Preparata adds alcohol reflux 1.5 hours, filters extracting solution, reclaims the ethanol in filtrate and is concentrated into appropriate, standby;
(2) medicinal residues add 50% alcohol reflux 1.5 hours, extracting liquid filtering, and filtrate recycling ethanol is also concentrated into appropriate, standby;
(3) medicinal residues add water backflow 2 hours, and decocting liquid filters, and filtrate is concentrated in right amount; Merge said extracted concentrated solution, dry, make Radix Aconiti Lateralis Preparata dried cream powder;
It is fragrant that (4) 75% ethanol 250ml dissolve 1g Moschus moschiferous;
(5) 45g Sanguis Draxonis, 48g Flos Carthami, take Radix Aconiti Lateralis Preparata dried cream powder (in Radix Notoginseng total arasaponins 6g) in appropriate step (3), with 98%7 alcohol 500ml immersions;
(6) 200g Radix Rehmanniae 98% soak with ethanol;
(7) medical material in step (4)-(6) soaked after 20 days, according to 1: 1: 1 ratio, mixed, and obtained MUSK SHUHUOLING.
Embodiment 4: clinical trial data (impact of Dichlorodiphenyl Acetate induced mice writhing)
Contrast groups: MUSK SHUHUOLING (the wide purchase in Sichuan).
Test group: according to the medicine of the embodiment of the present invention 1 preparation.
50 of ICR mices, male, body weight 20-22g, is divided into 8 groups at random by body weight, that is: model group, gavage gives same volume distilled water; Positive drug (aspirin) group, gavage gives aspirin 0.2g/kg; Matched group and test group 5g/kg, 10g/kg, 20g/kg, gastric infusion.Each is organized administration volume and is 0.2ml/10g.Administration every day 1 time, continuous 5 days.1h after last administration, each is organized mouse peritoneal and injects 0.6% glacial acetic acid 0.1ml/10g, observes the writhing number of times of mice in 15min, calculates suppression ratio.
Suppression ratio (%)=(the average writhing number of times of the average writhing number of times-administration of control group mice group mice) average writhing number of times * 100% of/control group mice
T check between experimental result employing group, relatively the difference between each group, calculates mean and standard deviation (± s).
Analgesic experiment result: the mouse writhing reaction due to matched group and test group 20g/kg, 10g/kg dosage group Dichlorodiphenyl Acetate has obvious inhibitory action, has compared significant difference (p < 0.001) with model group; The inhibitory action of matched group and test group does not have significant difference (p < 0.001).The results are shown in Table 1.
Table 1: the impact of Dichlorodiphenyl Acetate induced mice writhing response
Experimental example 5: clinical trial data (impact of xylol induced mice ear swelling)
Contrast groups: MUSK SHUHUOLING (the wide purchase in Sichuan).
Test group: according to the medicine of the embodiment of the present invention 1 preparation.
60 of ICR mices, male, body weight 26-30g, is divided into 10 groups at random by body weight, that is: model group, gavage gives same volume distilled water; Positive drug (aspirin) group, gavage gives aspirin 0.2g/kg; Test group and matched group 5g/kg, 10g/kg, 20g/kg, 30g/kg group, gavage gives various dose solution.Each is organized administration volume and is 0.2ml/10g.Administration every day 1 time, continuous 5 days.1h after last administration, each is organized the left ear tow sides of mice and evenly smears dimethylbenzene 0.05ml and cause inflammation, and auris dextra is smeared normal saline in contrast.Cause scorching rear 2h, mice dislocation is put to death, and uses the card punch of diameter 6mm in mice two ear same area punchings, weighing both sides auricle weight.Calculate swelling and swelling rate.
Swelling=left ear auricle weight-auris dextra auricle weight.
Swelling rate=(left ear auricle weight-auris dextra auricle weight)/auris dextra auricle weight * 100%.
T check between experimental result employing group, relatively the difference between each group, calculates mean and standard deviation (± s).
Antiinflammatory experimental result: the mice ear due to matched group and test group 10g/kg, 20g/kg, 30g/kg xylol all has inhibitory action, compared significant difference (p < 0.05) with model group, effect is dose dependent, and the inhibitory action of matched group and test group does not have significant difference.The results are shown in Table 2.
Table 2: the impact of xylol induced mice ear swelling
Claims (4)
1. a MUSK SHUHUOLING, is characterized in that, its composition raw material comprises Moschus, Radix Aconiti Lateralis Preparata, Flos Carthami, Sanguis Draxonis and Radix Rehmanniae.
2. MUSK SHUHUOLING as claimed in claim 1, the ingredient proportion that it is characterized in that described Moschus, Flos Carthami, Sanguis Draxonis and Radix Rehmanniae is 1: 30-50: 30-50: 120-200; The inventory of described Radix Aconiti Lateralis Preparata is in Radix Notoginseng total arasaponins amount, and the ingredient proportion of described Radix Notoginseng total arasaponins amount and Moschus is 3-6: 1.
3. MUSK SHUHUOLING as claimed in claim 1, is characterized in that described new MUSK SHUHUOLING, it is characterized in that in order to below legal system standby:
(1) Radix Aconiti Lateralis Preparata adds alcohol reflux, filters extracting solution, reclaims the ethanol in filtrate and is concentrated in right amount, dry, makes Radix Aconiti Lateralis Preparata dried cream powder;
(2) Moschus is dissolved in ethanol;
(3) Sanguis Draxonis, Flos Carthami, take Radix Aconiti Lateralis Preparata dried cream powder in appropriate step (1), by soak with ethanol;
(4) Radix Rehmanniae soak with ethanol;
(5) get the medical material soak in step (2)-(4), mix, obtain MUSK SHUHUOLING.
4. MUSK SHUHUOLING as claimed in claim 3, is characterized in that described new MUSK SHUHUOLING is standby in order to below legal system:
(1) Radix Aconiti Lateralis Preparata adds alcohol reflux, filters extracting solution, reclaims the ethanol in filtrate and is concentrated into appropriate, standby;
(2) medicinal residues add alcohol reflux, extracting liquid filtering, and filtrate recycling ethanol is also concentrated into appropriate, standby;
(3) medicinal residues add water backflow, and decocting liquid filters, and filtrate is concentrated in right amount; Merge said extracted concentrated solution, dry, make Radix Aconiti Lateralis Preparata dried cream powder;
(4) Moschus is dissolved in ethanol;
(5) Sanguis Draxonis, Flos Carthami, take Radix Aconiti Lateralis Preparata dried cream powder in appropriate step (3), by soak with ethanol;
(6) Radix Rehmanniae soak with ethanol;
(7) medical material in step (4)-(6) soaked after 10-45 days, got the medical material soak in step (2)-(5), obtained MUSK SHUHUOLING.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410222568.8A CN104042848B (en) | 2014-05-21 | 2014-05-21 | New MUSK SHUHUOLING |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410222568.8A CN104042848B (en) | 2014-05-21 | 2014-05-21 | New MUSK SHUHUOLING |
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| Publication Number | Publication Date |
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| CN104042848A true CN104042848A (en) | 2014-09-17 |
| CN104042848B CN104042848B (en) | 2017-09-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410222568.8A Active CN104042848B (en) | 2014-05-21 | 2014-05-21 | New MUSK SHUHUOLING |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104474186A (en) * | 2014-10-26 | 2015-04-01 | 四川光大制药有限公司 | Extraction method for Shexiang shuhuoling (moschus sinew-relaxing collateral-activating magic medicine) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1072343A (en) * | 1992-10-31 | 1993-05-26 | 武汉体育学院 | Musk shuhuo essence and preparation method thereof |
| CN1729997A (en) * | 2005-08-03 | 2006-02-08 | 包头中药有限责任公司 | Process for preparing musk pain-stopping spray |
| CN1840051A (en) * | 2006-01-23 | 2006-10-04 | 北京因科瑞斯生物制品研究所 | Pain-stopping gel with musk and its preparation method |
-
2014
- 2014-05-21 CN CN201410222568.8A patent/CN104042848B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1072343A (en) * | 1992-10-31 | 1993-05-26 | 武汉体育学院 | Musk shuhuo essence and preparation method thereof |
| CN1729997A (en) * | 2005-08-03 | 2006-02-08 | 包头中药有限责任公司 | Process for preparing musk pain-stopping spray |
| CN1840051A (en) * | 2006-01-23 | 2006-10-04 | 北京因科瑞斯生物制品研究所 | Pain-stopping gel with musk and its preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 张虹: "骨伤科附子常用药对(1)", 《中国中医药报》 * |
| 无: "麝香舒活灵质量标准", 《中国药品标准》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104474186A (en) * | 2014-10-26 | 2015-04-01 | 四川光大制药有限公司 | Extraction method for Shexiang shuhuoling (moschus sinew-relaxing collateral-activating magic medicine) |
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| CN104042848B (en) | 2017-09-12 |
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