CN1839949A - Glue for treating female genital system inflammation and its preparing process - Google Patents
Glue for treating female genital system inflammation and its preparing process Download PDFInfo
- Publication number
- CN1839949A CN1839949A CN 200610050927 CN200610050927A CN1839949A CN 1839949 A CN1839949 A CN 1839949A CN 200610050927 CN200610050927 CN 200610050927 CN 200610050927 A CN200610050927 A CN 200610050927A CN 1839949 A CN1839949 A CN 1839949A
- Authority
- CN
- China
- Prior art keywords
- radix
- oleum sesami
- stir
- catechu
- add
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a gel for treating female's inflammation of reproduction system and its preparing process, wherein the raw materials include rhubarb horsetails, sesame oil, alkanna tinctoria, black catechu, baras camphor, ethanol, propylene glycol, polysorbate 80, carbomer, and triethanolamine.
Description
Technical field
The invention belongs to the Chinese traditional patent formulation formulation art, relate in particular to a kind of gel for the treatment of female genital disease, also relate to its preparation method simultaneously.
Background technology
Heat-clearing and toxic substances removing, removing dampness and killing parasites is restrained antipruriticly, is used for the colpitis due to the various causes of disease.Curative effect Chinese medicine suppository preferably in the market, mainly there is following shortcoming in it: suppository dissolves easy outflow when using, and is greasy, and short in the intravaginal holdup time, the mucosal adhesive effect is poor, uses inconvenience, foreign body sensation is arranged and makes us not feeling well, and bioavailability is low etc.
Summary of the invention
The object of the present invention is to provide a kind of non-greasy, easily be coated with exhibition evenly, good absorbing; Nonirritant, intermiscibility is good; Bioavailability height, good stability, the gel of the treatment female genital disease that untoward reaction is few.
Another object of the present invention also is to provide the preparation method of the gel of this treatment female genital disease.
A kind of gel for the treatment of female genital disease of the present invention is made up of Radix Et Rhizoma Rhei, catechu, Radix Arnebiae (Radix Lithospermi), Borneolum Syntheticum and adjuvant, and wherein adjuvant is Oleum Sesami, ethyl hydroxybenzoate, ethanol, propylene glycol, polyoxyethylene sorbitan monoleate, carbomer.
In above-mentioned a kind of gel 1000 weight portions for the treatment of female genital disease, the weight portion of each raw material is:
Radix Et Rhizoma Rhei 134.79 catechu 48 Radix Arnebiae (Radix Lithospermi)s 54.79 Borneolum Syntheticums 3.84
Oleum Sesami 672 ethyl hydroxybenzoate 0.1-2 ethanol 10-400 propylene glycol 10-400
Polyoxyethylene sorbitan monoleate 2-50 carbomer 1-50 surplus is a water.
Above-mentioned each raw material preferred weight part is:
Radix Et Rhizoma Rhei 134.79 catechu 48 Radix Arnebiae (Radix Lithospermi)s 54.79 Borneolum Syntheticums 3.84
Oleum Sesami 672 ethyl hydroxybenzoate 0.1-2 ethanol 10-400 propylene glycol 10-400
Polyoxyethylene sorbitan monoleate 2-50 carbomer 1-50 surplus is a water.
A kind of preparation method for the treatment of the gel of female genital disease of the present invention, may further comprise the steps: it is cataclasm to get Radix Et Rhizoma Rhei by prescription, fried withered with Oleum Sesami with putting in the pot, remove slag, put coldly, add Radix Arnebiae (Radix Lithospermi) and soaked 72 hours, the elimination Radix Arnebiae (Radix Lithospermi), complement to 192 parts with the Oleum Sesami after the heating, get pastille Oleum Sesami, standby; With catechu suitable quantity of water heating for dissolving, cooling, standby; Get Borneolum Syntheticum and ethyl hydroxybenzoate, ethanol, propylene glycol, polyoxyethylene sorbitan monoleate mixed dissolution, standby; It is soluble in water that other gets carbomer, and swelling 24 hours stirs, and regulating PH with triethanolamine is 4.5～6, adds pastille Oleum Sesami, stir, add Borneolum Syntheticum solution, stir, add catechu solution again, stir, add water to 1000 parts, stir, the degassing, fill, promptly.
The present invention is Chinese medicine preparation " the rehabilitation spirit bolt " dosage changing form of existing national standard and getting compared with prior art, makes former suppository into gel.Main adjuvant adopts the carbomer swelling solution, it has mainly utilized the bioadhesive of carbomer, and the selection of each adjuvant and proportioning and manufacturing condition preferably obtain through testing repeatedly, can make the present invention reach prolong drug in intravaginal holdup time and nonirritant, improve the medicine local concentration, drug release rate is fast, adopts ejector sleeve formula packing simultaneously, makes that the patient is convenient to be used, the present invention is a water-soluble base, have non-greasy, easily be coated with exhibition evenly, good absorbing; Intermiscibility is good; Bioavailability height, good stability, the characteristics that untoward reaction is few.
The specific embodiment
Below further set forth treatment female genital disease of the present invention by stability test of the present invention and pharmacodynamics test gel have good stability, beneficial effect evident in efficacy.
One, stability test
1, centrifuging: get gel 10g, pack into and be with in the graduated centrifuge tube, with centrifugal 30 minutes of 3000 rev/mins of rotating speeds, gel is not stratified, and was haze-free.；
2, heat-resisting cold-resistant experiment: the gel embedding that makes in two Aluminium Foil Packages packs, was put 55 ℃ of baking oven constant temperature respectively 6 hours; Put-15 ℃ of refrigerators interior 24 hours, and all do not have the phenomenon that layering, muddiness and viscosity reduce.
3, reserved sample observing method: medicine is put in the room temperature, carry out the preliminarily stabilised test, put temperature 37-40 ℃, in the relative humidity 75%, carry out accelerated test, the performance assessment criteria pilot project is: character, discriminating, acidity, content uniformity, assay, limit test of microbe.Three batches of rehabilitation spirit gel samples are put in the room temperature and are investigated 6 months, the examination project indicator and comparison in 0 month, no significant change.Three batches of rehabilitation spirit gel sample accelerated tests are investigated 3 months, the examination project indicator and comparison in 0 month, no significant change.As seen, this product is being simulated under the commercially available back condition steady quality.
Two, pharmacodynamics test
The gel of treatment female genital disease of the present invention all has in various degree antibacterial bacteriostasis to 10 strain antibacterials such as external staphylococcus aureus, colon bacillus and white pearl bacterium result of the test; Its external bacteriostasis is better than corresponding suppository.To setting up vaginal congest, edema that rabbit colpitis mycotica model causes, good therapeutical effect being arranged; And rat paw edema rate due to energy obvious suppression dimethylbenzene induced mice ear swelling and the reduction carrageenin; The granuloma induced by implantation of cotton pellets proliferative inflammation there is not significant effect.Illustrate that the present invention is remarkable to the acute exudative inflammation effect.Obviously improve the itch-threshold of histamine phosphate, have itching-relieving action.
Illustrate the preparation method that the present invention treats the gel of female genital disease by the following examples.
Embodiment 1:
Take by weighing Radix Et Rhizoma Rhei 134.79g, catechu 5.48g, Radix Arnebiae (Radix Lithospermi) 54.79g, Borneolum Syntheticum 3.84g, it is cataclasm to get Radix Et Rhizoma Rhei, fried withered with putting in the pot with Oleum Sesami 356ml, removes slag, put coldly, add Radix Arnebiae (Radix Lithospermi) and soaked the elimination Radix Arnebiae (Radix Lithospermi) 72 hours, complement to 200ml with the Oleum Sesami after the heating, get pastille Oleum Sesami, standby; With catechu suitable quantity of water heating for dissolving, cooling, standby; Get Borneolum Syntheticum and 0.5g ethyl hydroxybenzoate, 80g ethanol, 100g propylene glycol, 15g polyoxyethylene sorbitan monoleate mixed dissolution, standby; Other gets the 12g Acritamer 940 and is dissolved in the 550g water, and swelling 24 hours stirs, and regulating PH with triethanolamine is 4.5～6, adds pastille Oleum Sesami, stir, add Borneolum Syntheticum solution, stir, add catechu solution again, stir, add water to 1000g, stir, the degassing, fill, promptly.
Embodiment 2:
Take by weighing Radix Et Rhizoma Rhei 134.79g, catechu 5.48g, Radix Arnebiae (Radix Lithospermi) 54.79g, Borneolum Syntheticum 3.84g, it is cataclasm to get Radix Et Rhizoma Rhei, fried withered with putting in the pot with Oleum Sesami 356ml, removes slag, put coldly, add Radix Arnebiae (Radix Lithospermi) and soaked the elimination Radix Arnebiae (Radix Lithospermi) 72 hours, complement to 200ml with the Oleum Sesami after the heating, get pastille Oleum Sesami, standby; With catechu suitable quantity of water heating for dissolving, cooling, standby; Get Borneolum Syntheticum and 1g ethyl hydroxybenzoate, 100g ethanol, 80g propylene glycol, 20g polyoxyethylene sorbitan monoleate mixed dissolution, standby; Other gets the 10g Acritamer 940 and is dissolved in the 550g water, and swelling 24 hours stirs, and regulating PH with triethanolamine is 4.5～6, adds pastille Oleum Sesami, stir, add Borneolum Syntheticum solution, stir, add catechu solution again, stir, add water to 1000g, stir, the degassing, fill, promptly.
Embodiment 3:
Take by weighing Radix Et Rhizoma Rhei 134.79g, catechu 5.48g, Radix Arnebiae (Radix Lithospermi) 54.79g, Borneolum Syntheticum 3.84g, it is cataclasm to get Radix Et Rhizoma Rhei, fried withered with putting in the pot with Oleum Sesami 356ml, removes slag, put coldly, add Radix Arnebiae (Radix Lithospermi) and soaked the elimination Radix Arnebiae (Radix Lithospermi) 72 hours, complement to 200ml with the Oleum Sesami after the heating, get pastille Oleum Sesami, standby; With catechu suitable quantity of water heating for dissolving, cooling, standby; Get Borneolum Syntheticum and 0.8g ethyl hydroxybenzoate, 120g ethanol, 100g propylene glycol, 10g polyoxyethylene sorbitan monoleate mixed dissolution, standby; Other gets the 13g Acritamer 940 and is dissolved in the 560g water, and swelling 24 hours stirs, and regulating PH with triethanolamine is 4.5～6, adds pastille Oleum Sesami, stir, add Borneolum Syntheticum solution, stir, add catechu solution again, stir, add water to 1000g, stir, the degassing, fill, promptly.
Embodiment 4:
Take by weighing Radix Et Rhizoma Rhei 134.79g, catechu 5.48g, Radix Arnebiae (Radix Lithospermi) 54.79g, Borneolum Syntheticum 3.84g, it is cataclasm to get Radix Et Rhizoma Rhei, fried withered with putting in the pot with Oleum Sesami 342g, removes slag, put coldly, add Radix Arnebiae (Radix Lithospermi) and soaked the elimination Radix Arnebiae (Radix Lithospermi) 72 hours, complement to 192g with the Oleum Sesami after the heating, get pastille Oleum Sesami, standby; With catechu suitable quantity of water heating for dissolving, cooling, standby; Get Borneolum Syntheticum and 0.5g ethyl hydroxybenzoate, 20g ethanol, 400g propylene glycol, 50g polyoxyethylene sorbitan monoleate mixed dissolution, standby; Other gets the 0.5g carbomer and is dissolved in the 550g water, and swelling 24 hours stirs, and regulating PH with triethanolamine is 4.5～6, adds pastille Oleum Sesami, stir, add Borneolum Syntheticum solution, stir, add catechu solution again, stir, add water to 1000g, stir, the degassing, fill, promptly.
Embodiment 5:
Take by weighing Radix Et Rhizoma Rhei 134.79g, catechu 5.48g, Radix Arnebiae (Radix Lithospermi) 54.79g, Borneolum Syntheticum 3.84g, it is cataclasm to get Radix Et Rhizoma Rhei, fried withered with putting in the pot with Oleum Sesami 342g, removes slag, put coldly, add Radix Arnebiae (Radix Lithospermi) and soaked the elimination Radix Arnebiae (Radix Lithospermi) 72 hours, complement to 192g with the Oleum Sesami after the heating, get pastille Oleum Sesami, standby; With catechu suitable quantity of water heating for dissolving, cooling, standby; Get Borneolum Syntheticum and 0.8g ethyl hydroxybenzoate, 300g ethanol, 10g propylene glycol, 2g polyoxyethylene sorbitan monoleate mixed dissolution, standby; Other gets the 20g carbomer and is dissolved in the 560g water, and swelling 24 hours stirs, and regulating PH with triethanolamine is 4.5～6, adds pastille Oleum Sesami, stir, add Borneolum Syntheticum solution, stir, add catechu solution again, stir, add water to 1000g, stir, the degassing, fill, promptly.
Claims (3)
1, a kind of gel for the treatment of female genital disease is characterized in that: the weight portion of each raw material is in its 1000 weight portion:
Radix Et Rhizoma Rhei 134.79 catechu 48 Radix Arnebiae (Radix Lithospermi)s 54.79 Borneolum Syntheticums 3.84
Oleum Sesami 672 ethyl hydroxybenzoate 0.1-2 ethanol 10-400 propylene glycol 10-400
Polyoxyethylene sorbitan monoleate 2-50 carbomer 1-50 surplus is a water.
2, the gel of treatment female genital disease as claimed in claim 1 is characterized in that: the weight portion of each raw material is in its 1000 weight portion:
Radix Et Rhizoma Rhei 134.79 catechu 48 Radix Arnebiae (Radix Lithospermi)s 54.79 Borneolum Syntheticums 3.84
Oleum Sesami 672 ethyl hydroxybenzoate 0.1-2 ethanol 10-400 propylene glycol 10-400
Polyoxyethylene sorbitan monoleate 2-50 carbomer 1-50 surplus is a water.
3, the preparation method of the gel of treatment female genital disease as claimed in claim 1 or 2, may further comprise the steps: it is cataclasm to get Radix Et Rhizoma Rhei by prescription, fried withered with Oleum Sesami with putting in the pot, remove slag, put coldly, add Radix Arnebiae (Radix Lithospermi) and soaked 72 hours, the elimination Radix Arnebiae (Radix Lithospermi), complement to 192 parts with the Oleum Sesami after the heating, get pastille Oleum Sesami, standby; With catechu suitable quantity of water heating for dissolving, cooling, standby; Get Borneolum Syntheticum and ethyl hydroxybenzoate, ethanol, propylene glycol, polyoxyethylene sorbitan monoleate mixed dissolution, standby; It is soluble in water that other gets carbomer, and swelling 24 hours stirs, and regulating PH with triethanolamine is 4.5～6, adds pastille Oleum Sesami, stir, add Borneolum Syntheticum solution, stir, add catechu solution again, stir, add water to 1000 parts, stir, the degassing, fill, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610050927 CN1839949A (en) | 2006-01-23 | 2006-01-23 | Glue for treating female genital system inflammation and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610050927 CN1839949A (en) | 2006-01-23 | 2006-01-23 | Glue for treating female genital system inflammation and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1839949A true CN1839949A (en) | 2006-10-04 |
Family
ID=37029252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610050927 Pending CN1839949A (en) | 2006-01-23 | 2006-01-23 | Glue for treating female genital system inflammation and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1839949A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455729B (en) * | 2009-01-14 | 2011-05-25 | 通化百信药业有限公司 | Kangfulingshuan medicine production technique |
| CN107625920A (en) * | 2017-10-11 | 2018-01-26 | 付金龙 | Gynaecology's gel and preparation method thereof |
-
2006
- 2006-01-23 CN CN 200610050927 patent/CN1839949A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455729B (en) * | 2009-01-14 | 2011-05-25 | 通化百信药业有限公司 | Kangfulingshuan medicine production technique |
| CN107625920A (en) * | 2017-10-11 | 2018-01-26 | 付金龙 | Gynaecology's gel and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1232202A (en) | Divisible tablet with delayed release of active substance and process for the production thereof | |
| CN102274200B (en) | Diclofenac sodium sustained release tablets and preparation process thereof | |
| CN101062022B (en) | Colchicine patch absorbing from skin for treating acute goute arthritis and the preparing method thereof | |
| CN101690818A (en) | Cataplasm matrix and preparation method thereof | |
| CN103070864A (en) | Repaglinide and metformin hydrochloride medicinal composition and its preparation method | |
| CN102973636A (en) | Common threewingnut root microemlusion-based gel preparation and preparation method thereof | |
| CN102850710B (en) | Framework material for medical plaster and preparation method thereof | |
| CN1839949A (en) | Glue for treating female genital system inflammation and its preparing process | |
| CN106983734B (en) | A kind of ibuprofen sustained release capsules and preparation method thereof | |
| CN1935242A (en) | Chinese medicine composition, and its preparing method and quality control method | |
| CN102641285A (en) | Compound omeprazole capsule and preparation method thereof | |
| CN109925287A (en) | A kind of Pyrochep and preparation method thereof | |
| CN104288278B (en) | Use of Periplaneta americana and Radix Sanguisorbae in combination drug | |
| CN102648922B (en) | Gamuzhuer medicinal latex preparation and preparation method thereof | |
| CN102631327A (en) | Enteric coated omeprazole pellet and preparation method thereof | |
| CN103142461B (en) | A kind of vaginal gel and preparation method thereof | |
| CN1839917A (en) | Glue for treating female genital system inflammation and its preparing process | |
| WO2004087126A1 (en) | Pharmaceutical composition containing platinum complex as active substance and method of manufacturing thereof | |
| CN1943629A (en) | Chinese cassia tree bark oil dripping pill and its preparing method | |
| CN103159737A (en) | Esomeprazole sodium compound and medicine composition | |
| CN102871973A (en) | Omeprazole sodium freeze-drying preparation and preparation method thereof | |
| CN1839983A (en) | Ointment for treating female genital system inflammation and its preparing process | |
| CN101991859A (en) | Beta-cyclodextrin inclusion compound of huperzine A, and preparation method and preparation thereof | |
| CN1739579A (en) | Chinese medicine prepn for removing blood stasis and activating blood circulation to dissipate blood stasis and its prepn process | |
| CN1939289A (en) | Allicin dropping balls and preparation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |