CN1814119A - Yougui capsule - Google Patents

Abstract

The invention discloses a method for preparing a Chinese Angelica capsule, comprisingRehmannia (Cooked), Giant Typhonium Rhizome, Cassia Bark, Common Yan Rhizome, Cherry Fruit, South Dodder Seed, Buckhom Glue, Fructus Lycii, Chinese Angelica Root, and Cortex Eucommiae. Its advantage lies in that it is a pure traditional Chinese medicine prepared of raw medicinal materials by repeated purification by modern biological medicinal engineering technology on the basis of Chinese Angelica pills recorded in the JingYue Pandect. It has characters of wide curing range, no toxicity and side effect, not producing resistance to drugs, hihg cure rate, and long-term curative effect. And large numbers of clinic applications prove it has remarkable curative effect on asynodia, spermatorrhea, chronic nephritis, nephropathy syndrome, osteoporosis, osteoproliferation, climacteric syndrome of women, sterility, anaemia, frequent micturition, postpartum hemorrhage, etc.

Description

Yougui capsule

Technical field

The present invention relates to a kind of preparation method of medicine, especially a kind of preparation method of Yougui capsule.

Background technology

At present Yougui Wan, the kidney-Yang-Reinforcing Bolus is a honeyed pill, and shortcoming such as be difficult for swallowing, mouthfeel is bad, easily go mouldy.

Summary of the invention

The object of the present invention is to provide a kind of preparation method of Yougui capsule, this Yougui capsule has overcome shortcomings such as honeyed pill is difficult for swallowing, mouthfeel is bad, easily go mouldy, and therapeutic domain extensively has no side effect, and fastness is strong.

Technical scheme of the present invention is: a kind of Yougui capsule comprises the raw material of following weight portion: 250-350 Radix Rehmanniae Preparata, 70-80 Radix Aconiti Lateralis Preparata, 70-80 Cortex Cinnamomi, 120-180 Rhizoma Dioscoreae, 100-125 Fructus Corni, 130-180 Semen Cuscutae, 130-180 Colla cornus cervi, 130-180 Fructus Lycii, 100-125 Radix Angelicae Sinensis, the 130-180 Cortex Eucommiae in this medicine.The preparation method of this medicine, follow these steps to the preparation: Cortex Cinnamomi, Radix Angelicae Sinensis steam respectively gets volatile oil, the volatile oil of collection with beta-schardinger dextrin-inclusion, drying, pulverize, sieve.Standby, the aqueous solution after distillation device is in addition collected; Medicinal residues and Radix Rehmanniae Preparata, Radix Aconiti Lateralis Preparata, Rhizoma Dioscoreae, mountain Lay cornel, Semen Cuscutae, Fructus Lycii, the Cortex Eucommiae seven flavors decoct with water 1-3 time, and each 1.5-2.5 hour, the aqueous solution after collecting decoction and the distillation, filter, filtrate is concentrated into relative density under 60～110 ℃ of temperature be 1.0～1.50 clear paste, adds ethanol and make and contain the alcohol amount and reach 30%～80%, fully stir, the centrifugal supernatant that gets reclaims ethanol, be condensed into thick paste, it is an amount of to add adjuvant such as dextrin, starch etc., and drying under reduced pressure is pulverized, sieve, get extract powder; The Colla cornus cervi drying under reduced pressure is pulverized, sieve, and with above-mentioned extract powder and Benexate Hydrochloride mixing, incapsulate, make 1000, promptly.

The invention has the advantages that: Yougui capsule is on the basis of Yougui Wan, the kidney-Yang-Reinforcing Bolus in Jing-Yue Complete Works, uses modern biological medicine engineering, through crude drug in whole being purified repeatedly, make with extra care the pure Chinese medicinal preparation that forms.This product has overcome shortcomings such as honeyed pill is difficult for swallowing, mouthfeel is bad, easily go mouldy, and therapeutic domain extensively has no side effect, do not develop immunity to drugs, and the cure rate height, curative effect is lasting.A large amount of clinical practices prove, Yougui capsule is to the weakness of QI Mental fatigue, sexual impotence, seminal emission, chronic nephritis, the nephrotic syndrome, osteoporosis, hyperosteogeny, joint are ached, menopausal syndrome, infertility, anemia, frequent micturition, the kidney yang deficiency syndrome grain urine disease, losing blood puerperal etc. has significant curative effect.

Experimentation

The experimentation of Yougui treatment syndrome of deficiency of kidney-YANG is duplicated rabbit syndrome of deficiency of kidney-YANG model with hydroxyurea, observe the situation of change of Yougui to biochemical indicator and hydrocortisone before and after the treatment of model rabbit, display model rabbit total protein level after the Yougui treatment is recovered to some extent as a result, liver function, renal function acute injury are in time controlled, the cholesterol synthetic quantity increases, triglyceride levels obviously falls after rise, hydrocortisone and lactic dehydrogenase jealous woman level significantly raise, the full one-tenth amount of sugar increases, glycolysis intensity improves, and rabbit body temperature gos up.With before the modeling relatively, syndrome of deficiency of kidney-YANG model rabbit is after the Yougui treatment, except that total protein, other every biochemical indicators all return to level before the modeling, a series of metabolism disorder phenomenons obtain correcting and improving.

Yougui is to the influence of removal ovary rat bone density and serum I GF-1 level

Duan Yumings etc. are made osteoporosis model with 30 female sd inbred rats removal ovaries, be divided into experimental group, positive controls, blank group at random, give AREA (area), BMKC (bone mineral content), the BMD (bone density) of Yougui, calcium preparation, normal saline filling stomach 3 months, dual intensity X line fixed point mensuration Global (whole rat) and R lumbar vertebra respectively, and detect serum I GF-1 (insulin like growth factor) level.The result shows that Yougui can effectively keep bone density, the raising rat blood serum IGF-1 secretion level of removal ovary rat.

Yougui capsule shows the clinical preceding animal test results of this product syndrome of deficiency of kidney-YANG sexual impotence and seminal emission patient's clinical research and moving Jiangxi Prov. Medicine Inst: this product can make erection shortening incubation period of castrated rats; Increase male childhood of rat weight of seminal vesicle; Prolong the syndrome of deficiency of kidney-YANG mice swimming with a load attached to the body time; The body temperature that suppresses the syndrome of deficiency of kidney-YANG mice reduces.

Urology Department: the nephrotic syndrome, chronic nephritis, glomerulonephritis hematuria etc., the simple CRF patient's with western medical treatment of method (wherein to the syndrome of deficiency of kidney-YANG patient based on Yougui) treatment chronic renal failure (CRF) patient that Lu Yeming adopts 112 examples the combination of Chinese and Western medicine and 86 examples curative effect has been carried out controlled observation, the decline of the CRF of treatment group as a result patient glomerular filtration rate significantly delays, and reduces blood urea nitrogen, suppresses serum creatinine and rises, it treats effective 86.6%, obviously is better than 38.4% of matched group.Wang Peixiang treats with Yougui syndrome of deficiency of kidney-YANG chronic nephritis patient, has obtained curative effect preferably clinically.

Orthopaedics: osteoporosis, various degeneration osteoarthrosis pains, soreness of waist and knee joint, hyperosteogeny etc.

Xu Zhengfa etc. treat syndrome of deficiency of kidney-YANG osteoporosis 96 examples with Yougui, take the photograph sheet and CT examination evaluation curative effect with the X line, incidence, lumbago and skelalgia sx person 65 examples after 20 days, the lumbago and skelalgia symptom person of being clearly better 88 examples after 40 days, pain symptom disappearance person 90 examples after 60 days, 88 examples are taken the photograph the sheet inspection through the X line, and bone density and bone trabecula obviously improve.

Cao Jian demonstrate,proves 46 examples with Yougui for the main treatment chondromalacia patella, and 14 days is a course of treatment, and after 2 course of therapy, clinical total effective rate is 93.5%.

Urology department: sexual impotence, seminal emission, sexual hypofunction etc.

How tame clinical drug discovery assay unit such as The Affiliated Hospital to Jiangxi College of Traditional Chinese Medicine shows that to the result of study of 240 routine sexual impotence, seminal emission, sexual hypofunction, hair loss patient the effective percentage of the great waves Yougui capsule of putting forth one's strength treatment is respectively 93%, 91%, 87%, 88%.

Gynecological: climacteric syndrome, infertility

Yang Liying adopts Yougui to add flavor treatment syndrome of deficiency of kidney-YANG climacteric syndrome and infertility, has all obtained satisfied curative effect.

Big internal medicine: old, the weakness of QI Mental fatigue, endocrine function is low, the kidney yang deficiency syndrome diabetes, the bad anemia of reproducibility etc.

The specific embodiment

The 75g Cortex Cinnamomi, 112.5g steaming respectively, Radix Angelicae Sinensis gets volatile oil, the volatile oil beta-schardinger dextrin-inclusion of collecting, dry, pulverize, sieve, standby, aqueous solution after distillation device is in addition collected: medicinal residues and 300g Radix Rehmanniae Preparata, 75g Radix Aconiti Lateralis Preparata (gun tab), the 150g Rhizoma Dioscoreae, 112.5g Fructus Corni (wine moxibustion), the 150g Semen Cuscutae, the 150g Fructus Lycii, the 150g Cortex Eucommiae (salt stir-fry) seven flavors decoct with water 2 times, each 2 hours, aqueous solution after collecting decoction and the distillation, filter, filtrate is concentrated into the clear paste that relative density is 1.08～1.10 () under 60～65 ℃ of temperature, add equivalent ethanol, fully stir, the centrifugal supernatant that gets reclaims ethanol, be condensed into thick paste, it is an amount of to add dextrin, and drying under reduced pressure is pulverized, sieve, get extract powder; The Colla cornus cervi drying under reduced pressure is pulverized, sieve, and with above-mentioned extract powder and Benexate Hydrochloride mixing, incapsulate, make 1000, promptly.

Claims (1)

1, a kind of Yougui capsule comprises the raw material of following weight portion in this medicine:

Radix Rehmanniae Preparata 250-350 Radix Aconiti Lateralis Preparata 70-80 Cortex Cinnamomi 70-80 Rhizoma Dioscoreae 120-180

Fructus Corni 100-125 Semen Cuscutae 130-180 Colla cornus cervi 130-180 Fructus Lycii 130-180

Radix Angelicae Sinensis 100-125 Cortex Eucommiae 130-180;

The preparation method of this medicine follows these steps to preparation:

Cortex Cinnamomi, Radix Angelicae Sinensis steams respectively gets volatile oil, the volatile oil beta-schardinger dextrin-inclusion of collecting, dry, pulverize, sieve, standby, aqueous solution after distillation device is in addition collected: medicinal residues and Radix Rehmanniae Preparata, Radix Aconiti Lateralis Preparata, Rhizoma Dioscoreae, Fructus Corni, Semen Cuscutae, Fructus Lycii, the Cortex Eucommiae seven flavors decoct with water 1-3 time, each 1.5-2.5 hour, aqueous solution after collecting decoction and the distillation filters, and filtrate is concentrated into relative density under 60～65 ℃ of temperature be 1.08～1.10 clear paste, add equivalent ethanol, fully stir, the centrifugal supernatant that gets reclaims ethanol, be condensed into thick paste, it is an amount of to add dextrin, and drying under reduced pressure is pulverized, sieve, get extract powder; The Colla cornus cervi drying under reduced pressure is pulverized, sieve, and with above-mentioned extract powder and Benexate Hydrochloride mixing, incapsulate, make 1000, promptly.