CN1814099A - Medicine for treating and preventing vein-injuries resulted from chemical medicine, and use thereof - Google Patents

Medicine for treating and preventing vein-injuries resulted from chemical medicine, and use thereof Download PDF

Info

Publication number
CN1814099A
CN1814099A CN 200510101391 CN200510101391A CN1814099A CN 1814099 A CN1814099 A CN 1814099A CN 200510101391 CN200510101391 CN 200510101391 CN 200510101391 A CN200510101391 A CN 200510101391A CN 1814099 A CN1814099 A CN 1814099A
Authority
CN
China
Prior art keywords
medicine
vein
radix
phlebitis
arteries
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN 200510101391
Other languages
Chinese (zh)
Inventor
刘宗潮
黄丽源
吴剑辉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TUMOR PREVENTION AND THERAPY CENTER ZHONGSHAN UNIV
Original Assignee
TUMOR PREVENTION AND THERAPY CENTER ZHONGSHAN UNIV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TUMOR PREVENTION AND THERAPY CENTER ZHONGSHAN UNIV filed Critical TUMOR PREVENTION AND THERAPY CENTER ZHONGSHAN UNIV
Priority to CN 200510101391 priority Critical patent/CN1814099A/en
Publication of CN1814099A publication Critical patent/CN1814099A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicines Containing Plant Substances (AREA)

Abstract

The invention provides the use of a medicine for curing and preventing vein damage caused by chemical drugs, and the medicine is prepared of prepared Frankincense, prepared Myrrha, Danshen, Rhizoma Chuanxiong, Chinese Angelica, Rhizoma Corydalis, Pubescent Holly Root, coptis root, Amur Corktree Bark, Baical Skullcap Root, Dragon's blood, Red Peony Root, Safflower, Leech, Indigowoad Leaf, and borneol in a certain proportion and is a Chinese medicinal preparation for curing and preventing phlebitis caused by chemical drugs and local inflammatory damage caused by exosmosis of chemical drugs as applied by vein.

Description

Be used for the treatment of purposes with prevention vein-injuries resulted from chemical medicine medicine
[technical field]
The present invention relates to a kind of being used for the treatment of and the purposes of preventing the vein-injuries resulted from chemical medicine medicine.
[background technology]
The part chemicals that is used for clinical diagnosis and treatment disease has the strong impulse effect, and intravenously administrable can cause phlebitis, makes vein and surrounding tissue red and swollen heat pain thereof, the vein hardening, and venous occlusion can appear in severe patient; The drug extravasation that intravenously administrable causes can cause the topochemistry inflammation, and the severe patient local organization occurs downright bad.The medical worker handles phlebitis and local chemical inflammation disease with diverse ways for a long time, and curative effect is undesirable.The Hirudoid that Germany produces has certain curative effect to phlebitis.
Theory of Chinese medical science thinks that the phlebitis of resulted from chemical medicine belongs to heresy and attacks venation, and blood vessels are injured, the blood stasis sering; The medicine local tissue damage belongs in the evil poison and accumulates, and injures skin, uses heat-clearing and toxic substances removing, and blood stasis dispelling is promoted blood circulation, the reducing swelling and alleviating pain Drug therapy.
[summary of the invention]
The object of the present invention is to provide a kind of being used for the treatment of and the purposes of preventing the vein-injuries resulted from chemical medicine medicine, this pharmaceutical preparation is in preparation treatment and the application that prevents in the vein-injuries resulted from chemical medicine medicine, and the composition of described pharmaceutical preparation and the component of each composition are: Olibanum (processed) 5-7.5 part, Myrrha (processed) 5-7.5 part, Radix Salviae Miltiorrhizae 5-7.5 part, Rhizoma Chuanxiong 5-7.5 part, Radix Angelicae Sinensis 5-7.5 part, Rhizoma Corydalis 5-7.5 part, Radix Ilicis Pubescentis 5-7.5 part, Rhizoma Coptidis 4-6 part, Cortex Phellodendri 4-6 part, Radix Scutellariae 4-6 part, Sanguis Draxonis 4-6 part, Radix Paeoniae Rubra 4-6 part, Flos Carthami 3-4.5 part, Hirudo 3-4.5 part, Folium Isatidis 3-4.5 part, Borneolum Syntheticum 0.1-0.15 part.
Pharmaceutical preparation of the present invention can be made water preparation, liniment, liniment, cream, ointment, patch with the medicine of said ratio.
Pharmaceutical preparation of the present invention is executed according to differential diagnosis in tcm and is controlled main points, select ten for use surplus kind of Chinese medicine form, execute water-bath and decoct into the external of fluid extractum, be used for the treatment of the phlebitis of various resulted from chemical medicine and the local inflammation damage that the chemicals intravenously administrable exosmoses and causes.
Pharmaceutical preparation of the present invention is a kind of Chinese medicine preparation, is used for the treatment of and prevents the caused local inflammation damage of exosmosing of the phlebitis of resulted from chemical medicine and chemicals intravenously administrable.
Pharmaceutical preparation of the present invention proves by mouse experiment, can effectively treat (tail) phlebitis of antitumor drug.
Pharmaceutical preparation of the present invention is through clinical checking for many years, and the vein of resulted from chemical medicine and red and swollen heat pain on every side thereof can effectively be eliminated or alleviate to affected part of exterior coating, the inflammation damnification that treatment phlebitis and drug extravasation cause.The long-term coating medicine-feeding of the present invention is to being subjected to coating skin vacuum response, do not cause that skin sends out bleb and ulcer.
[specific embodiment]
Be pharmaceutical preparation of the present invention (trade name is that arteries and veins the is scorching flat) testing data relevant below with function.
One: the making of the scorching flat preparation of arteries and veins
Choose Chinese medicines such as superior Olibanum (processed) 120g, Myrrha (processed) 120g, Radix Salviae Miltiorrhizae 120g, Rhizoma Chuanxiong 120g, Radix Angelicae Sinensis 120g, Rhizoma Corydalis 120g, Radix Ilicis Pubescentis 120g, Rhizoma Coptidis 96g, Cortex Phellodendri 96g, Radix Scutellariae 96g, Sanguis Draxonis 96g, Radix Paeoniae Rubra 96g, Flos Carthami 72g, Hirudo 72g, Folium Isatidis 72g, Borneolum Syntheticum 2.4g, clear water soaked 2 hours, executing water-bath decocts 3 times, gather and filter, collect 3 filtrates and in water-bath, be concentrated into the 1.5g/ml crude drug, for zoopery and clinical use.
Two: arteries and veins is scorching flat to the phlebitis caused therapeutical effect of antitumor drug Novi benzene (navelbine).
Method: get 15 of the kunming mices of body weight 20-24g, be divided into 3 groups, 5 every group, first group every tail vein slowly injects normal saline, is coated with normal saline 1 time every day outward, continuous 7 days; Second group every the benzene 0.4ml of Novi that the slow injection concentration of tail vein is 10mg/ml is coated with normal saline 1 time every day outward, continuous 7 days; The 3rd group every the benzene 0.4ml of Novi that the slow injection concentration of tail vein is 10mg/ml is coated with arteries and veins every day outward scorching flat 1 time, continuous 7 days.Put to death 3 groups of all animals, the tail 4-5mm at the nearly root 2cm of clip place on the 8th day.10% formalin fixed, dehydration of alcohol, decalcification, paraffin embedding, section 3-4 μ m, take off cured, HE dyeing.Microscopically is observed and is shown that first group of vein is intact, NIP sign; Second group of vein narrows down, and intimal thickening has thrombosis; The 3rd group of vein do not have that obvious tube chamber narrows down and the intimal thickening phenomenon.
Three: arteries and veins is scorching flat to the phlebitic clinical observation of chemicals
(1) clinical data and medication
1. clinical use also causes phlebitic chemotherapeutics that cisplatin (DDP), 5-fluorouracil (5FU), NVB (NVB), cyclophosphamide (CTX), vincristine (VCR), amycin (ADM), docetaxel (Taxotere), bleomycin (BLM) etc. are arranged.Select for use above-mentioned 2~4 kinds of medicines to form chemotherapy regimen.The small part case is used other zest medicine, wherein has several amino acids, fructose, high concentration glucose solution to add multiple liver-protecting medicine, CT contrast agent etc.
2. clinical data and grouping
For the sympathy to the patient, this paper does not adopt does not have the medicine of therapeutical effect as negative control to phlebitis.In the 93 routine phlebitis cases of receiving treatment, have 21 the example since the treatment after can not be with examining, curative effect is not bright, can not assess, and excludes this group statistical material; Can accept standard treatment and warp and include this group statistical material in 72 examples of examining and assessing.
Can put down the 72 routine cancer therapy drug induced phlebitis patients that estimate and be divided into two groups respectively; Phlebitis length is that 5~19cm does not wait.Every group is divided into I, II, III degree again by the phlebitic order of severity, and every group of case load equates; The grouping back scorching degree of two groups of patient's vein has good comparability.Experimental group 36 examples use arteries and veins scorching flat, the hirudoid cream that matched group 36 examples use Sankyo pharma GmbH to produce.Show that from the treatment case of having observed the scorching flat produce effects of arteries and veins is fast, therefore, other 22 routine local lamellars struvite red, swollen, hot, the patient all uses the arteries and veins inflammation to bring treatment under control bitterly.
3. phlebitis calibration
With nineteen ninety U.S.'s injection nursing association defined grade scale.
4. method
Two kinds of outer respectively affected part skins of medicine, are observed and are write down the time that sings and symptoms improves and disappears at every day three times.
(2) result
1. the scorching flat therapeutical effect of arteries and veins (see Table 1 and table 2) to the medicine induced phlebitis.
The scorching flat comparison of table 1 arteries and veins to medicine induced phlebitis pain regression time
The phlebitis calibration Use medicine Case load Pain regression time (h) after the medication Multiple * The P value
Total time Average time ± standard deviation Maximum duration
I II III The scorching flat hirudoid cream arteries and veins of the scorching flat hirudoid cream arteries and veins of hirudoid cream arteries and veins is scorching flat 16 16 11 11 9 9 303 12.57 266 9.33 240 93 18.94±6.5 0.78±0.75 24.18±1.89 0.85±0.61 26.67±3.22 10.33±8.8 26 27 28 22 34 24 24.0 28.4 2.6 <0.01 <0.01 <0.01
*The ratio of scorching average equal time of hirudoid cream and arteries and veins
The scorching flat comparison of table 2 arteries and veins to the red and swollen regression time of medicine induced phlebitis
The phlebitis calibration Use medicine Case load Red and swollen regression time (h) after the medication Multiple * The P value
Total time Average time ± standard deviation Maximum duration
I II III The scorching flat hirudoid cream arteries and veins of the scorching flat hirudoid cream arteries and veins of hirudoid cream arteries and veins is scorching flat 16 16 11 11 9 9 710 161 504 228.83 532 240 44.38±17.22 10.06±9.9 45.80±10.49 20.80±13.12 61.30±15.65 26.67±18.76 72 24 72 48 90 72 4.4 2.2 2.3 <0.01 <0.01 <0.01
*The ratio of scorching average equal time of hirudoid cream and arteries and veins
2. the arteries and veins inflammation is put down the therapeutical effect to the local tissue damage of zest drug-induced
Other has 22 cases because drug extravasation shows local lamellar inflammation, occurs red, swollen, hot, bitterly, with scorching flat back 16 cases (accounting for 72.7%) red and swollen heat pain disappearance healing extremely fully that applies of arteries and veins.Have red, swollen, hot behind 6 examples (accounting for 27.3 ‰) the treatments 72h, alleviate to some extent bitterly, do not disappear fully yet.

Claims (1)

1. the pharmaceutical preparation application in the medicine of preparation treatment and prevention vein-injuries resulted from chemical medicine is characterized in that described pharmaceutical preparation made by the following weight proportion raw material: Olibanum (processed) 5-7.5 part, Myrrha (processed) 5-7.5 part, Radix Salviae Miltiorrhizae 5-7.5 part, Rhizoma Chuanxiong 5-7.5 part, Radix Angelicae Sinensis 5-7.5 part, Rhizoma Corydalis 5-7.5 part, Radix Ilicis Pubescentis 5-7.5 part, Rhizoma Coptidis 4-6 part, Cortex Phellodendri 4-6 part, Radix Scutellariae 4-6 part, Sanguis Draxonis 4-6 part, Radix Paeoniae Rubra 4-6 part, Flos Carthami 3-4.5 part, Hirudo 3-4.5 part, Folium Isatidis 3-4.5 part, Borneolum Syntheticum 0.1-0.15 part.
CN 200510101391 2005-11-18 2005-11-18 Medicine for treating and preventing vein-injuries resulted from chemical medicine, and use thereof Pending CN1814099A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 200510101391 CN1814099A (en) 2005-11-18 2005-11-18 Medicine for treating and preventing vein-injuries resulted from chemical medicine, and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 200510101391 CN1814099A (en) 2005-11-18 2005-11-18 Medicine for treating and preventing vein-injuries resulted from chemical medicine, and use thereof

Publications (1)

Publication Number Publication Date
CN1814099A true CN1814099A (en) 2006-08-09

Family

ID=36906531

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 200510101391 Pending CN1814099A (en) 2005-11-18 2005-11-18 Medicine for treating and preventing vein-injuries resulted from chemical medicine, and use thereof

Country Status (1)

Country Link
CN (1) CN1814099A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101559127B (en) * 2009-05-25 2011-04-06 贾荣娟 Traditional Chinese medicine ointment for treating stage II chemotherapy-induced phlebitis and preparation method
CN103083519A (en) * 2013-02-27 2013-05-08 冯莉霞 Traditional Chinese medicine composition for preventing and treating chemotherapeutic extravasation injury and preparation method and application thereof
CN103432362A (en) * 2013-08-31 2013-12-11 青岛市市立医院 Chinese medicinal composition for promoting mature of internal arteriovenous fistula and reducing complications, application and using method thereof
CN103446261A (en) * 2012-06-05 2013-12-18 中国医学科学院肿瘤医院 Chinese medicinal composition used for preventing and/or treating related skin lesion in tumour treatment
CN105194037A (en) * 2015-10-16 2015-12-30 黄金凤 Externally applied drug for treating phlebitis

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101559127B (en) * 2009-05-25 2011-04-06 贾荣娟 Traditional Chinese medicine ointment for treating stage II chemotherapy-induced phlebitis and preparation method
CN103446261A (en) * 2012-06-05 2013-12-18 中国医学科学院肿瘤医院 Chinese medicinal composition used for preventing and/or treating related skin lesion in tumour treatment
CN103083519A (en) * 2013-02-27 2013-05-08 冯莉霞 Traditional Chinese medicine composition for preventing and treating chemotherapeutic extravasation injury and preparation method and application thereof
CN103083519B (en) * 2013-02-27 2014-09-17 冯莉霞 Traditional Chinese medicine composition for preventing and treating chemotherapeutic extravasation injury and preparation method and application thereof
CN103432362A (en) * 2013-08-31 2013-12-11 青岛市市立医院 Chinese medicinal composition for promoting mature of internal arteriovenous fistula and reducing complications, application and using method thereof
CN105194037A (en) * 2015-10-16 2015-12-30 黄金凤 Externally applied drug for treating phlebitis

Similar Documents

Publication Publication Date Title
CN1814099A (en) Medicine for treating and preventing vein-injuries resulted from chemical medicine, and use thereof
CN1679904A (en) Chinese medicine for treating cardiac failure
CN103933468A (en) Traditional Chinese medicine for treating acute pancreatitis
CN1814100A (en) Medicine for treating and preventing vein injuries resulted from chemical medicine
CN101683441A (en) Traditional Chinese medicine composition for invigorating blood circulation and dissolving stasis
CN1305515C (en) Chinese medicinal powder and decoction composition for treating cancer
CN103127463A (en) External Chinese medicine preparation for phlebophlogosis
CN102940870B (en) Chinese medicinal composition for treating burns and scalds
CN1116051C (en) Black ointment
CN101559125B (en) Burning powder
CN1175841C (en) Chinese medicine for treating tinea and antipruritic
CN104667176A (en) Traditional Chinese medicine for treating malignant arrhythmia of coronary heart disease
CN1778362A (en) Formula for treating wind heat and headache
CN1164288C (en) Medicine compoistion for traeting burns and scalds
CN102614324A (en) Chinese medicinal synthetic preparation for assisting western medicines in treating phlebophlogosis
CN1341436A (en) Eexternal-use Chinese medicine plaster for curing deafness and tinnitus
CN102114174B (en) Traditional Chinese medicine for treating acute cholecystitis
CN103285324A (en) Medicine composition for treating phlebitis
CN109125464A (en) A kind of External-applicationtraditional traditional Chinese medicinal for treating phlebitis
CN1958054A (en) Prescription of external wash liquid of duplicated solarized Chinese traditional medicine, and preparation method
CN1778371A (en) Formula for treating wind-cold headache
CN1305510C (en) Medicine for treating intractable fever
CN105770548A (en) Externally-used traditional Chinese medicine for treating skin eczema
CN100350957C (en) Composition for curing psoriasis
CN106620158A (en) Medicine composition for treating psoriasis and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication