CN1813941A - Chinese and western compounded drug for treating alveolysis and its preparing method - Google Patents

Abstract

The present invention discloses a medicine composition for effectively curing odontopathy and its preparation process. It is made up by using metronidazole, erythromycin, prednisone, crude gypsum, cimicifuga root and asarum as raw material through a certain preparation process. It can be made into capsule preparation, and its effective rate is above 95%.

Description

Medicine of collaborative treatment of Chinese and western medicines odontopathy and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of odontopathy and preparation method thereof, medicine of particularly a kind of collaborative treatment of Chinese and western medicines odontopathy and preparation method thereof.

Background technology

As everyone knows, people in daily life, environment and the interference of external environment and the reasons such as change of diet in being subjected to, again because some people's hypoimmunity, parts of body all might produce disease, tooth and oral cavity are no exception, bacterial equilibrium in the oral cavity is damaged, and the anaerobe growth is rapid, and the breeding of antibacterial changes speeds up bacterial growth, thereby broken antibacterial, the environment of anaerobe, various oral pathology and odontopathy will take place, general because the toothache that odontopathy causes has following several: 1, dental caries (decayed tooth or dental caries), its be run into cold, heat, acid, just feel pain when sweet, the dental caries of the degree of depth is because of near dental pulp, runs into that pain increases the weight of when stimulating; 2, acute pulpitis (toothache), it is the main cause that causes violent toothache, is divided into: a, spontaneous pain, paroxysmal pain, hypnalgia, the violent pain of generation that tooth is spontaneous, pain is a burst of, stop a burst of, night pain more violent than the daytime; B, hot and cold stimulation aggravate the pain, and it is obvious to run into stimulation pain in early days, and it is obvious to meet thermostimulation pain late period; C, pain delocalization are radial pain along the nervi trigeminus distributed areas often; D, the jumping pain that continues when suppurate late period; 3, acute pericementitis, pain are very violent, are the jumping pain of persistence, and tooth can not crunching, and painful tooth it feels like grows the sensation that has tooth to float than other teeth; 4, acute pericoronitis of the wisdom tooth, corona face upper part have gingiva covering and food impaction, inflammation easily, red swelling of gingiva, and constant pain is opened little with laryngalgia and mouth sometimes; 5, dentium nitor severe dental attrition, dentin exposes, and distributes because of nerve ending is arranged on it, causes and meets hot and cold and mechanical stimulation, just feels pain; 6, neck portion wedge shaped defect because gingival atrophy and brush teeth enamel is worn exposes soft dentin, runs into stimulation pain; In addition, hyperpietic's pulp hyperemia, former tired prefectures such as diabetics dental pulp vascular inflammatory necrosis can cause toothache.

At present, the medicine of state's internal therapy toothache mainly contains following several:

1, artificial Calculus Bovis's metronidazole, it is to be used for acute tooth pericoronitis, the local tooth abscess that is pickled with grains or in wine, pulpitis, periapical periodontitiss etc., weak point are that Time of Administration is long, DeGrain;

2, metronidazole fenbufen capsule, it is to be used for diseases such as gingivitis, periodontitis, and stomatitis, glossitis etc. is also had certain curative effect, and weak point is that Time of Administration is long, and curative effect is not remarkable, and analgesic effect is not good enough;

3, periodontal is peaceful, is used for diseases such as gingival hemorrhage that alveolysis causes, periodontal abscess, and deficiency is not have analgesic effect, and antiinflammatory speed is slow, and administration time is long;

In sum, all there is certain shortcoming in the sick medicine of treatment toothache at present, need be improved.

Summary of the invention

The object of the present invention is to provide medicine of a kind of collaborative treatment of Chinese and western medicines odontopathy and preparation method thereof, solved that treatment odontopathy medicine administration time commonly used is long, analgesic effect is not good enough and problem such as curative effect is not obvious.The present invention is with the Chinese medicine and western medicine combination, and the compatibility of drugs of multiple effect coexistence is made compound preparation, and Time of Administration is short, and analgesic effect is good, and is evident in efficacy, reached the purpose for the treatment of both the principal and the secondary aspects of a disease at the same time; Toothaches such as its major function is applicable to toothache due to stomach-fire, the toothache of damaging by worms, nervous toothache, periodontitis, pulpitis, periapical periodontitis, the poor abscess of tooth.

The present invention is according to the traditional Chinese medical science, doctor trained in Western medicine theory, and in conjunction with the long-term practice experience, selected metronidazole, erythromycin, bold and vigorous mud pine, Rhizoma Cimicifugae, Gypsum Fibrosum, Herba Asari are prepared from.

Selected metronidazole is a Western medicine in the present invention prescription, record in nineteen ninety-five two ones of the version Pharmacopoeias of the People's Republic of China.Be widely used in the treatment of anaerobic infection, periodontitis, the poor abscess of tooth, pulpitis, periapical periodontitis are had therapeutical effect preferably: its character is white or off-white color sheet: metronidazole is a nitro imidazole derivatives, the redox reaction that can suppress ameba, the protozoon nitrogen chain is ruptured, metronidazole has killing action to anaerobe, the metabolite that generates when it reduces in human body also has the anaerobe resistant effect, synthesizing of the DNA (deoxyribonucleic acid) of inhibition antibacterial, thereby disturb the growth of antibacterial, breeding finally causes antibacterial death.

Erythromycin, Western medicine, record in nineteen ninety-five two ones of the version Pharmacopoeias of the People's Republic of China mainly plays antibacterial and anti-inflammation functions in the present invention, and it has good inhibition effect to the pars oralis pharyngis bacterial strain; Its character is white or off-white color; Erythromycin belongs to macrolide antibiotics, to staphylococcus, and the equal tool antibacterial activity of each group B streptococcus and Grain-positive bacillus; Neisseria, hemophilus influenza, pertussis Bao Te Salmonella etc. also can present sensitivity to erythromycin, and erythromycin is also had an antibacterial activity to the various anaerobe except that bacteroides fragilis and Fusobacterium; Legionnella, campylobacter fetus, some spirillum, mycoplasma pneumoniae, rickettsiae and chlamydiaceae also there is inhibitory action; Erythromycin is antibacterial, but when high concentration some antibacterial is also had a bactericidal action; It can see through the red after birth of antibacterial, locate to become the reversibility combination for position (" P " position) approaching with the 50S subunit of bacterial ribosome, having blocked tRNA (PIA) is bonded on " P " position, also blocked simultaneously polypeptide chain from a displacement that is subjected to position (" A " position) to " P " position, thereby bacterioprotein is synthetic is suppressed.Erythromycin is only effective to mitotically active antibacterial.

Sprinkle the mud pine, Western medicine, record in nineteen ninety-five two ones of the version Pharmacopoeias of the People's Republic of China.Have antiinflammatory action, thus the performance that can alleviate and prevent to organize the reaction to inflammation to reduce inflammation; Hormone inflammation-inhibiting cell, the synthetic and release of inflammation-inhibiting chemistry mediator; Immunosuppressive action is used for patient's autoimmune inflammation disease; Its character is a white tablets, and sprinkling the mud pine is Aeroseb-Dex, has antiinflammatory, antiallergic, rheumatism, immunosuppressive action, and the mechanism of action is: 1 antiinflammatory action, and can alleviate and prevent to organize reaction inflammation, thus the performance that reduces inflammation; Hormone inflammation-inhibiting cell comprises macrophage and leukocyte in the gathering of inflammation part, and suppresses phagocytosis, the release of lysosomal enzyme and inflammation chemistry mediator synthetic and discharging; 2 immunosuppressive actions, comprise and prevent or suppress cell-mediated immunoreation, the anaphylaxis of retardance, reduce T lymphocyte, mononuclear cell, oxyphil cell's number, reduce the binding ability of immunoglobulin and cell surface receptor, and suppress the synthetic of interleukin and discharge, from but reduce T lymphocyte and lymphoblastic transformation, and alleviate and formerly send out expansion immunoreactive; Immune complex can be reduced by basement membrane, and the concentration of complement component and immunoglobulin can be reduced.

Rhizoma Cimicifugae is a Chinese medicine, cold nature, and it is little sweet, bitter to distinguish the flavor of, record in one one of the version Pharmacopoeia of the People's Republic of China in 1977.Character is irregular microscler bulk, and multi-branched is nodositas, long 10～20cm, diameter 2～4cm; Surface pitchy or sepia, coarse injustice has hard thin fibrous root residual, and the stem foot trace in several circular cavities is arranged above, and the hole inwall shows netted rill; Below uneven, the tool mark of fibrous root; Body is light, and matter is hard, frangibility not, and the section unevenness has the crack, fibroid, yellow green or yellowish white; Feeble QI, mildly bitter flavor and puckery.Its diffusing wind heat, rash, ascending spleen-QI; Be used for headache due to pathogenic wind-heat, gingivitis, measles without adequate eruption, gastroptosis, chronic diarrhea, proctoptosis, uterine prolapse, Chronic Benzene Poisoning, thrombocytopenia.

Gypsum Fibrosum, property Great Cold, sweet in the mouth, suffering, record in one one of the version Pharmacopoeia of the People's Republic of China in 1977.Character is fibrous crystallization polymer, is long bulk or irregular bulk, and is not of uniform size; White, canescence or faint yellow, what have is translucent, or with pewter or lark lamellar impurity; Body weight, matter is crisp, easily longitudinal fracture, hands is twisted with the fingers can be broken, the fibrous texture of vertical section tool, and a sample gloss is arranged; Odorless, lightly seasoned; Give birth to and quench the thirst with the expelling pathogenic factors from muscles for clearing heat relieving restlessness; Control that the calentura high fever does not move back, vexed unconsciousness and delirium is gone mad mouthful, thirsty dry pharynx, the lung-heat dyspnea with rapid respiration, middle administration spontaneous perspiration, gastritis headache, toothache, hyperactivity of toxic heat are sent out the speckle dermexanthesis, aphtha of the mouth and tongue is forged deposited promoting tissue regeneration and ulcer healing, external treatment cellulitis skin infection is burst and is not closed up, Tang Huotang hinders.

Herba Asari, warm in nature, acrid in the mouth, little hardship, record in one one of the version Pharmacopoeia of the People's Republic of China in 1977, character is long 15～25cm, the long 1～3cm of rhizome, surface irregularity and is given birth to most cylindrical radiculas, and the about 0.1cm of diameter is filbert to yellowish-brown; Stem circle art shape, diameter 0.1～0.2cm, yellow green is to light brown, and the carefully vertical crest line of tool is by white pubescence; Matter is crisp, and the section yellow-white has marrow or hollow; Basal leaf leaf-shrinkage, fragmentation, complete person is the shape of falling ovum lanceolar or cochlear after flattening, long 1.5～9cm, wide 0.5～1.3cm; Yellow green, the blunt circle of tip has short point, and base portion is gradually narrow, full edge; The stem leaf alternate, lanceolar, long 1～6cm, wide 0.3～1cm, base portion is embraced stem, and give birth on the head inflorescence top, the flat obovate of achene, its effect: heat radiation is induced sweat, expelling wind and removing dampness, activating collaterals to relieve pain is used for paralysis, pathogenic wind-warm arthralgia pain, traumatic injury, stomachache, toothache, flu.

The prescription of medicine of the present invention following (percentage by weight):

Metronidazole 20～40 erythromycin 10～25

Sprinkle mud pine 5～15 Gypsum Fibrosum 3～12

Rhizoma Cimicifugae 2～8 Herba Asaris 10～25

The optimization formula of medicine of the present invention following (percentage by weight):

Metronidazole 40 erythromycin 20

Sprinkle mud pine 10 Gypsum Fibrosum 6

Rhizoma Cimicifugae 4 Herba Asaris 20

Medicine of the present invention can be made various oral formulations by various conventional peroral dosage form preparation methoies, below is the preferred dosage form of medicine of the present invention and preparation method:

A, by weight percentage get metronidazole, erythromycin, sprinkle three kinds of raw material medicated powder of mud pine, fully mix homogeneously is standby;

B, with the Gypsum Fibrosum cleaning, drying, break into fritter, remove impurity; Rhizoma Cimicifugae is removed slightly bubble of impurity, cleaning, drying; Herba Asari is removed impurity, and spray quinoline clear water is cleaned, and moistens slightly, and cutting is dried in the shade; With above Chinese medicine by " requirement of Chinese pharmacopoeia concocted specification is pulverized, and crosses 100 mesh sieves, and deposits by weight percentage, and is standby;

C, Chinese medicine fine powder and the abundant mix homogeneously of Western medicine mix homogeneously raw material powder that will be by weight percentage sieve, and make capsule formulation by capsule preparation requirements, and every 0.5g puts shady and cool dry locating and preserves.

The invention has the advantages that: the present invention is compound preparation, the Chinese medicine and western medicine combination, composition interacts, according to Chinese Pharmacopoeia and new pharmacology textual criticism, do not find that the three kind Western medicine of the present invention in filling a prescription share the toxic and side effects that human body is produced excess, three kinds of Western medicine share heat-clearing and toxic substances removing, anti-inflammation, its therapeutic effect highly significant; Contained composition is small in every medicine, and is short because of dentistry illness administration time, can not produce human body and poison; Taking convenience, each component meet the pharmaceutical control law regulation, and medicine meets state food health legislation regulation; The odontopathy best results is treated in medicine smelting of the present invention, and effective percentage reaches more than 95%, and cure rate reaches more than 85%.

The specific embodiment:

Embodiment 1:

Get crude drug by following percentage by weight:

Metronidazole 40 erythromycin 18

Sprinkle mud pine 12 Gypsum Fibrosum 10

Rhizoma Cimicifugae 5 Herba Asaris 15

Preparation method is:

A, with metronidazole, erythromycin, sprinkle three kinds of raw material medicated powder of mud pine, fully mix homogeneously is standby;

B, with the Gypsum Fibrosum cleaning, drying, break into fritter, remove impurity; Rhizoma Cimicifugae is removed slightly bubble of impurity, cleaning, drying; Herba Asari is removed impurity, and spray quinoline clear water is cleaned, and moistens slightly, and cutting is dried in the shade; With above Chinese medicine by " requirement of Chinese pharmacopoeia concocted specification is pulverized, and crosses 100 mesh sieves, and is standby:

C, with Chinese medicine fine powder and the abundant mix homogeneously of Western medicine raw material powder, sieve, make capsule formulation by capsule preparation requirements, every 0.5g puts shady and cool dry place and preserves.

Embodiment 2:

Get crude drug by following percentage by weight:

Metronidazole 30 erythromycin 25

Sprinkle mud pine 12 Gypsum Fibrosum 8

Rhizoma Cimicifugae 5 Herba Asaris 20

Preparation method is identical with embodiment 1.

Embodiment 3:

Get crude drug by following percentage by weight:

Metronidazole 35 erythromycin 15

Sprinkle mud pine 12 Gypsum Fibrosum 8

Rhizoma Cimicifugae 6 Herba Asaris 24

Preparation method is identical with embodiment 1.

Claims (3)

1, a kind of medicine of collaborative treatment of Chinese and western medicines odontopathy is characterized in that: it is the medicament of being made by following weight percentages:

Metronidazole 20～40 erythromycin 10～25

Sprinkle mud pine 5～15 Gypsum Fibrosum 3～12

Rhizoma Cimicifugae 2～8 Herba Asaris 10～25.

2, the medicine of a kind of collaborative treatment of Chinese and western medicines odontopathy according to claim 1 is characterized in that: the optimum ratio of each raw material is:

Metronidazole 40 erythromycin 20

Sprinkle mud pine 10 Gypsum Fibrosum 6

Rhizoma Cimicifugae 4 Herba Asaris 20.

3, a kind of preparation method of medicine of collaborative treatment of Chinese and western medicines odontopathy is characterized in that:

A, by weight percentage get metronidazole, erythromycin, sprinkle three kinds of raw material medicated powder of mud pine, fully mix homogeneously is standby;

B, with the Gypsum Fibrosum cleaning, drying, break into fritter, remove impurity; Rhizoma Cimicifugae is removed slightly bubble of impurity, cleaning, drying; Herba Asari is removed impurity, and spray quinoline clear water is cleaned, and moistens slightly, and cutting is dried in the shade; With above Chinese medicine by " requirement of Chinese pharmacopoeia concocted specification is pulverized, and crosses 100 mesh sieves, and weighing by weight percentage deposit treat standby;

C, Chinese medicine fine powder and Western medicine mix homogeneously raw material powder abundant mix homogeneously once more that will be by weight percentage sieve, and make capsule formulation by capsule preparation requirements, and every 0.5g puts shady and cool dry locating and preserves.