CN106619676A - Painkiller for relieving toothache - Google Patents
Painkiller for relieving toothache Download PDFInfo
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- CN106619676A CN106619676A CN201611011438.5A CN201611011438A CN106619676A CN 106619676 A CN106619676 A CN 106619676A CN 201611011438 A CN201611011438 A CN 201611011438A CN 106619676 A CN106619676 A CN 106619676A
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- toothache
- analgesic
- glucurolactone
- carrageenan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a painkiller for relieving toothache. The painkiller for relieving toothache is mainly prepared from, by weight, 13-18 parts of buluofen, 2-6 parts of aceclofenac, 10-20 parts of aspirin, 13-15 parts of indometacin, 4-9 parts of glucurolactone, 2-6 parts of carrageenan, 0.2-0.7 part of buckthorn bismuth magnesium, 5-8 parts of tamoxifen and 2-8 parts of sodium citrate. The painkiller is mainly used for treating pains caused by tooth decay, wind-heat toothache, periodontitis, odontalgia nervosa, toothache caused by bacterial infection and the like. In use, a user only needs to apply the finished drug to an affected part, toothache can be relieved within 3-5 sec, and an ideal treating effect can be realized.
Description
Technical field
The present invention relates to a kind of field of medicine preparation, specifically a kind of analgesic for alleviating toothache.
Background technology
Tooth is a kind of in structure present on many vertebratess, and tooth is the most hard organ of human body.People's
There are two secondary natural teeths in all one's life, and a pair is deciduous teeth, and a pair is permanent teeth.After deciduous teeth have fallen, permanent teeth has just been grown.Permanent teeth can not be again after falling
It is raw.With the progress and development of social science and technology, artificial tooth becomes the 3rd secondary tooth of the mankind.People in daily life, by tooth
Cooperation carry out sounding and speak, chew the behaviors such as diet.Meanwhile, tooth it is healthy, attractive in appearance also tight with our daily each side
Close correlation.Each tooth is divided into corona, root of the tooth and the part of neck three.Corona is the part for being exposed to oral cavity, pure white and glossy;
Root of the tooth is embedded in alveolus, is combined with sclerotin by means of periodontal membrane, and there is a hole root of the tooth tip, referred to as apical foramen, has blood vessel, nerve to go out
Enter, neck is part slightly thin between corona and root of the tooth, and outsourcing is with gingiva.The construction of tooth is mainly made up of dentine, in tooth root
One layer of cementin (cementum) is surrounded by outside dentine, and has white, light, hard enamel on crown portion surface.Enamel is
Calcification degree highest tissue in human body.Lacuna inside tooth is referred to as in teeth cavity, teeth cavity full of blood vessel, nerve and connective tissue,
Referred to as dental pulp.Intraoral lactobacilluss can make saccharide zymolysis produce acid, cause enamel decalcification, produce cavity, and clinic is referred to as dental caries.
If cavity is constantly deepened, involve the nerve of dental pulp, then can cause severe pain.Toothache refers to the pain that tooth causes because of a variety of causes,
For one of symptom common in oral disease, it is seen that in dental caries, pulpitiss, periapical periodontitiss, tooth trauma, dentin hypersensitiveness, wedge-like
Defect etc..Toothache is caused dental pulp (dental nerve) infection to be drawn by gingivitiss and periodontitis, dental caries (decayed tooth) or Fractured teeth mostly
Rise.Be due to not noting oral hygiene, tooth be subject to the soft tartar that the thing such as food debriss, antibacterial is formed around tooth and
Caused by the reasons such as the long-time stimulus caused by the tartar of hard, and incorrect tooth-brushing habit, vitamin deficiency.
Therefore, it is badly in need of a kind of suitable good effect of research and development, speed is fast, price is low, the analgesic that has no toxic side effect.
The content of the invention
It is an object of the invention to provide it is a kind of for alleviate toothache analgesic, to solve above-mentioned background technology in propose
Problem.
For achieving the above object, the present invention provides following technical scheme:
A kind of analgesic for alleviating toothache, be according to the primary raw material of weight portion:To isobutylphenyl propanoic acid 13-18
Part, aceclofenac 2-6 parts, aspirin 10-20 parts, indomethacin 13-15 parts, glucurolactone 4-9 parts, carrageenan 2-6 parts, Mus
Lee's bismuth magnesium 0.2-0.7 parts, Tamoxifen 5-8 parts, sodium citrate 2-8 parts.
As further scheme of the invention:The analgesic for alleviating toothache, according to the primary raw material of weight portion
For:To in isobutylphenyl propanoic acid 14-16 parts, aceclofenac 3-5 parts, aspirin 13-18 parts, indomethacin 13-15 parts, Portugal's aldehyde
Ester 5-8 parts, carrageenan 2-6 parts, Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium 0.4-0.6 parts, Tamoxifen 5-8 parts, sodium citrate 3-6 parts.
As further scheme of the invention:The analgesic for alleviating toothache, according to the primary raw material of weight portion
For:To 15 parts of isobutylphenyl propanoic acid, 4 parts of aceclofenac, 16 parts of aspirin, 14 parts of indomethacin, 7 parts of glucurolactone, OK a karaoke club
4 parts of glue, 0.5 part of Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium, 7 parts of Tamoxifen, 5 parts of sodium citrate.
A kind of preparation method for alleviating the analgesic of toothache, concretely comprises the following steps:
First, in pharmaceutical grade clean area, weigh to isobutylphenyl propanoic acid, aceclofenac, Ah Si by above-mentioned metering ratio
Woods, indomethacin, glucurolactone, carrageenan, Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium, Tamoxifen, sodium citrate, sieve, and addition is super after machinery is mixed
Pure water, in placing pharmacy mixer, mixes 4-8min, controls RSD≤5%, and tabletting and cold drying after mixing, temperature control exists
4-8 DEG C, packaging obtains final product the analgesic for alleviating toothache.
As further scheme of the invention:Mix 6min in concrete steps.
As further scheme of the invention:Temperature control is at 6 DEG C in concrete steps.
Compared with prior art, the invention has the beneficial effects as follows:
The diseases such as main treatment decayed tooth ache of the invention, acute toothache, periodontitis, nervous toothache, bacterial infectious toothache, make
Used time, as long as this finished medicines is coated on into site of disease, it was rid of the toothache in 3-5 second, reaches ideal treatment.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than the embodiment of whole.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of analgesic for alleviating toothache, be according to the primary raw material of weight portion:To 13 parts of isobutylphenyl propanoic acid, vinegar
Fragrant 2 parts of the acid of chlorine, 10 parts of aspirin, 13 parts of indomethacin, 4 parts of glucurolactone, 2 parts of carrageenan, 0.2 part of Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium, triphen
5 parts of oxygen ammonia, 2 parts of sodium citrate.
A kind of preparation method for alleviating the analgesic of toothache, concretely comprises the following steps:
First, in pharmaceutical grade clean area, weigh to isobutylphenyl propanoic acid, aceclofenac, Ah Si by above-mentioned metering ratio
Woods, indomethacin, glucurolactone, carrageenan, Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium, Tamoxifen, sodium citrate, sieve, and addition is super after machinery is mixed
Pure water, in placing pharmacy mixer, mixes 4min, controls RSD≤5%, tabletting and cold drying after mixing, and temperature control is 4
DEG C, packaging obtains final product the analgesic for alleviating toothache.
Embodiment 2
A kind of analgesic for alleviating toothache, be according to the primary raw material of weight portion:To 14 parts of isobutylphenyl propanoic acid, vinegar
Fragrant 3 parts of the acid of chlorine, 13 parts of aspirin, 13 parts of indomethacin, 5 parts of glucurolactone, 2 parts of carrageenan, 0.4 part of Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium, triphen
5 parts of oxygen ammonia, 3 parts of sodium citrate.
A kind of preparation method for alleviating the analgesic of toothache, concretely comprises the following steps:
First, in pharmaceutical grade clean area, weigh to isobutylphenyl propanoic acid, aceclofenac, Ah Si by above-mentioned metering ratio
Woods, indomethacin, glucurolactone, carrageenan, Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium, Tamoxifen, sodium citrate, sieve, and addition is super after machinery is mixed
Pure water, in placing pharmacy mixer, mixes 4min, controls RSD≤5%, tabletting and cold drying after mixing, and temperature control is 4
DEG C, packaging obtains final product the analgesic for alleviating toothache.
Embodiment 3
A kind of analgesic for alleviating toothache, be according to the primary raw material of weight portion:To 15 parts of isobutylphenyl propanoic acid, vinegar
Fragrant 4 parts of the acid of chlorine, 16 parts of aspirin, 14 parts of indomethacin, 7 parts of glucurolactone, 4 parts of carrageenan, 0.5 part of Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium, triphen
7 parts of oxygen ammonia, 5 parts of sodium citrate.
A kind of preparation method for alleviating the analgesic of toothache, concretely comprises the following steps:
First, in pharmaceutical grade clean area, weigh to isobutylphenyl propanoic acid, aceclofenac, Ah Si by above-mentioned metering ratio
Woods, indomethacin, glucurolactone, carrageenan, Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium, Tamoxifen, sodium citrate, sieve, and addition is super after machinery is mixed
Pure water, in placing pharmacy mixer, mixes 6min, controls RSD≤5%, tabletting and cold drying after mixing, and temperature control is 6
DEG C, packaging obtains final product the analgesic for alleviating toothache.
Embodiment 4
A kind of analgesic for alleviating toothache, be according to the primary raw material of weight portion:To 16 parts of isobutylphenyl propanoic acid, vinegar
Fragrant 5 parts of the acid of chlorine, 18 parts of aspirin, 15 parts of indomethacin, 8 parts of glucurolactone, 6 parts of carrageenan, 0.6 part of Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium, triphen
8 parts of oxygen ammonia, 6 parts of sodium citrate.
A kind of preparation method for alleviating the analgesic of toothache, concretely comprises the following steps:
First, in pharmaceutical grade clean area, weigh to isobutylphenyl propanoic acid, aceclofenac, Ah Si by above-mentioned metering ratio
Woods, indomethacin, glucurolactone, carrageenan, Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium, Tamoxifen, sodium citrate, sieve, and addition is super after machinery is mixed
Pure water, in placing pharmacy mixer, mixes 8min, controls RSD≤5%, tabletting and cold drying after mixing, and temperature control is 8
DEG C, packaging obtains final product the analgesic for alleviating toothache.
Embodiment 5
A kind of analgesic for alleviating toothache, be according to the primary raw material of weight portion:To 18 parts of isobutylphenyl propanoic acid, vinegar
Fragrant 6 parts of the acid of chlorine, 20 parts of aspirin, 15 parts of indomethacin, 9 parts of glucurolactone, 6 parts of carrageenan, 0.7 part of Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium, triphen
8 parts of oxygen ammonia, 8 parts of sodium citrate.
A kind of preparation method for alleviating the analgesic of toothache, concretely comprises the following steps:
First, in pharmaceutical grade clean area, weigh to isobutylphenyl propanoic acid, aceclofenac, Ah Si by above-mentioned metering ratio
Woods, indomethacin, glucurolactone, carrageenan, Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium, Tamoxifen, sodium citrate, sieve, and addition is super after machinery is mixed
Pure water, in placing pharmacy mixer, mixes 8min, controls RSD≤5%, tabletting and cold drying after mixing, and temperature control is 8
DEG C, packaging obtains final product the analgesic for alleviating toothache.
Clinical trial
1st, case source
300 toothache volunteer patients, man 150, female 150, year are screened in out-patient department of West China Hospital of Stomatology, Sichuan University
12~65 years old age, 40.7 years old mean age, periodontal disease patient 213, eurodonticus 204, periodontitis 75, pulpitiss 56,
Dentin hypersensitiveness 82, has a toothache and shows as:Persistence or intermittent pain, red swelling of gingiva, partly there is bleeding, patient's toothache
Time is most short one day, most long 17 days, average 7.4 days.All patients are equally divided into into 5 groups, each group patient's no difference of science of statistics.
2nd, the above-mentioned 5 groups of patients of Therapeutic Method take respectively the analgesic of the preparation of above-described embodiment 3 according to the method for the present invention,
It is within 3rd a course for the treatment of, daily 2 times, each 1g observes therapeutic outcome after a course for the treatment of.
3rd, criterion of therapeutical effect is effective:The clinical symptoms such as dental pain, red and swollen bleeding all disappear;Effectively:Toothache attack times
And substantially mitigate before the degree ratio treatment of pain during outbreak.It is invalid:Symptom is without significant change before and after treatment or increases.
4th, result:Analgesic prepared by embodiment 3, effective total number of persons is 287, and efficiently individual quantity is 8, and invalid number is
5, total effective rate is 98.3%.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of spirit or essential attributes without departing substantially from the present invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of description is only that for clarity those skilled in the art should
Using description as an entirety, the technical scheme in each embodiment can also Jing it is appropriately combined, form those skilled in the art
Understandable other embodiment.
Claims (6)
1. a kind of analgesic for alleviating toothache, it is characterised in that the primary raw material according to weight portion is:To isobutylphenyl third
Sour 13-18 parts, aceclofenac 2-6 parts, aspirin 10-20 parts, indomethacin 13-15 parts, glucurolactone 4-9 parts, carrageenan
2-6 parts, Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium 0.2-0.7 parts, Tamoxifen 5-8 parts, sodium citrate 2-8 parts.
2. the analgesic for alleviating toothache according to claim 1, it is characterised in that it is described for alleviate toothache only
Pain medicine, be according to the primary raw material of weight portion:To isobutylphenyl propanoic acid 14-16 parts, aceclofenac 3-5 parts, aspirin 13-18
Part, indomethacin 13-15 parts, glucurolactone 5-8 parts, carrageenan 2-6 parts, Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium 0.4-0.6 parts, Tamoxifen 5-8 parts,
Sodium citrate 3-6 parts.
3. it is according to claim 1 and 2 for alleviate toothache analgesic, it is characterised in that it is described for alleviate toothache
Analgesic, be according to the primary raw material of weight portion:To 15 parts of isobutylphenyl propanoic acid, 4 parts of aceclofenac, 16 parts of aspirin,
14 parts of indomethacin, 7 parts of glucurolactone, 4 parts of carrageenan, 0.5 part of Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium, 7 parts of Tamoxifen, 5 parts of sodium citrate.
4. it is a kind of as described in claim 1-3 is arbitrary for alleviate toothache analgesic preparation method, it is characterised in that tool
Body step is:
First, in pharmaceutical grade clean area, weigh to isobutylphenyl propanoic acid, aceclofenac, aspirin, Yin by above-mentioned metering ratio
Diindyl U.S. is pungent, glucurolactone, carrageenan, Fructus rhamni (Rhamnus davurica Pall.) bismuth magnesium, Tamoxifen, sodium citrate, sieves, and machinery adds ultra-pure water after mixing,
In placing pharmacy mixer, mix 4-8min, control RSD≤5%, tabletting and cold drying after mixing, temperature control is in 4-8
DEG C, packaging obtains final product the analgesic for alleviating toothache.
5. it is according to claim 4 for alleviate toothache analgesic preparation method, it is characterised in that in concrete steps
Mixing 6min.
6. it is according to claim 4 for alleviate toothache analgesic preparation method, it is characterised in that in concrete steps
Temperature control is at 6 DEG C.
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CN201611011438.5A CN106619676A (en) | 2016-11-17 | 2016-11-17 | Painkiller for relieving toothache |
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CN201611011438.5A CN106619676A (en) | 2016-11-17 | 2016-11-17 | Painkiller for relieving toothache |
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Cited By (1)
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CN108553471A (en) * | 2018-04-29 | 2018-09-21 | 广东伊茗药业有限公司 | A kind of tapentadol hydrochloride celecoxib preparation |
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CN101627986A (en) * | 2009-08-14 | 2010-01-20 | 海南永田药物研究院有限公司 | Acedofenac-paracetamol pharmaceutical composite and liposome solid preparation thereof |
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2016
- 2016-11-17 CN CN201611011438.5A patent/CN106619676A/en active Pending
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WO2007103540A3 (en) * | 2006-03-08 | 2008-12-18 | Pharmena North America Inc | Combination therapy with non-selective cox inhibitors to prevent cox-related gastric injuries |
CN101305969A (en) * | 2008-07-08 | 2008-11-19 | 美国Okoic公司 | Oral cavity sterilized sanitary accessories |
CN101627986A (en) * | 2009-08-14 | 2010-01-20 | 海南永田药物研究院有限公司 | Acedofenac-paracetamol pharmaceutical composite and liposome solid preparation thereof |
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CN108553471A (en) * | 2018-04-29 | 2018-09-21 | 广东伊茗药业有限公司 | A kind of tapentadol hydrochloride celecoxib preparation |
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