CN1813892B - Medicinal composition for treating coronary disease and angina pectoris and its use - Google Patents
Medicinal composition for treating coronary disease and angina pectoris and its use Download PDFInfo
- Publication number
- CN1813892B CN1813892B CN 200510061809 CN200510061809A CN1813892B CN 1813892 B CN1813892 B CN 1813892B CN 200510061809 CN200510061809 CN 200510061809 CN 200510061809 A CN200510061809 A CN 200510061809A CN 1813892 B CN1813892 B CN 1813892B
- Authority
- CN
- China
- Prior art keywords
- angina pectoris
- radix
- lignum
- standby
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention discloses a medicine composition for effectively curing coronary heart disease and angina pectoris. Said medicine composition is formed from 6 Chinese medicinal materials of salvia root, corydalis tuber, pueraria root, notoginseng, dalbergia wood and sappan wood. It can be made into various oral dosage forms. Besides, said invention also provides its preparation method and concrete steps.
Description
Technical field
The present invention relates to field of medicaments, more specifically say so a kind of treatment treating coronary heart disease and angina pectoris compositions and application thereof.
Background technology
Along with the mankind's development, the progress and the growth in the living standard of society, the rejuvenation of world population aging and morbidity colony has become one of principal element of harm humans health.Particularly cardiovascular and cerebrovascular disease is as human second major disease, and the trend of average annual growth is fairly obvious. and angina pectoris is a kind of caused by the temporary transient ischemia of cardiac muscle, anoxia, and outbreak has chest pain, chest discomfort such as uncomfortable in chest often.Angina pectoris is meant that it accounts for 90% of patients with coronary heart disease because coronary atherosclerosis or spasm cause myocardial ischemia, the caused angina pectoris of anoxia.
The method of treatment angina pectoris is based on blood vessel dilating, reduction blood viscosity, antiplatelet aggregation, anticoagulation at present.The Western medicine of clinical practice mostly is nitrate esters, nitrous acid ester, beta-receptor resistance preparation, calcium antagonist etc., but mostly is symptomatic treatment and course of disease progress is not had bigger effect, and what have has a bigger toxic and side effects, should not take for a long time.After for example taking nitroglycerin, occur jumping pain, palpitating speed in feeling of fullness in the head, the head sometimes, even faint.Find to cause severe hypotension in recent years again, easily produce problem such as toleration, hindered its application clinically.
At the deficiencies in the prior art recited above, the objective of the invention is to provide a kind of efficient, quick-acting, stably treat and prevent the Chinese traditional compound medicine of the distressed angor of coronary disease.
The research of new theory of Chinese medical science of compound basis of the present invention and modern pharmacology.Theory of Chinese medical science thinks that blood stasis stagnates heart arteries and veins, and the blood vessels operation is not smooth, becomes homeless fosterly and cause the heart, and the thoracic obstruction and pained takes place.On the basis of long-term pharmacological testing and clinical investigation, through the prescription screening, be monarch drug with Radix Puerariae, Radix Salviae Miltiorrhizae, Rhizoma Corydalis, Radix Notoginseng are ministerial drug, Lignum Dalbergiae Odoriferae, Lignum Sappan are adjuvant drug, the merit of tool blood circulation promoting and blood stasis dispelling, diffusing impediment and relieving pain, causing resuscitation with aromatic drugs.The present invention forms above-mentioned six kinds of components with suitable adjuvant is refining, be the medicine of a kind of ideal prevention and treatment angina pectoris etc.Modern pharmacological research of the present invention shows, we have blood flow effect, the effect of removing free radical, antiplatelet aggregative activity and the effect for reducing blood fat that increases patient's ischemic region, energy is the diastole coronary artery obviously, coronary blood flow increasing also promotes side Zhi Xunhuan, improve the ischemic region blood supply, dwindle the infarction size effect; The hydroxy radical that can remove hypoxic-ischemic and produce; alleviate the damage of hydroxy radical to myocardial mitochondria; and ATP content in the raising myocardial mitochondria; the effect of performance protection cardiac muscle can suppress the release of platelet factor significantly, prevents platelet aggregation; and raising POI/IXA2 ratio; produce anticoagulant and anti-thrombosis function, give birth to cholesterol in suppressing, thus and the generation of reduction TG, LDL. improved the curative effect of control angina pectoris greatly.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, characteristics at angina pectoris, with Radix Puerariae, Radix Salviae Miltiorrhizae is that monarch drug, Rhizoma Corydalis, Radix Notoginseng are that ministerial drug, Lignum Dalbergiae Odoriferae, Lignum Sappan are adjuvant drug, make have blood circulation promoting and blood stasis dispelling, the effect of diffusing impediment and relieving pain, causing resuscitation with aromatic drugs, can be used for preventing and treating the medicine of angina pectoris etc.The present invention adopts peroral dosage form, easy to use, mouthfeel is good, and cost is low, compares with similar Western medicine, its prescription is reasonable, technology is strict, have evident in efficacyly, have no side effect, the patient easily accepts, suitable advantage such as take for a long time provides a kind of pharmaceutical composition that good result is arranged to angina pectoris prevention and treatment.Its purpose realizes by following technical proposals.
Radix Puerariae 1～50% Radix Salviae Miltiorrhizae 1～50% Radix Notoginseng 1～35%
Rhizoma Corydalis 1～35% Lignum Dalbergiae Odoriferae 1～30% Lignum Sappan 1～30%
The preferable range of described each component is:
Radix Puerariae 15～35% Radix Salviae Miltiorrhizaes 15～35% Radix Notoginseng 15～35%
Rhizoma Corydalis 15～35% Lignum Dalbergiae Odoriferaes 5～20% Lignum Sappans 5～20%
Described each components contents is preferably:
Radix Puerariae 25% Radix Salviae Miltiorrhizae 25% Radix Notoginseng 20%
Rhizoma Corydalis 20% Lignum Dalbergiae Odoriferae 10% Lignum Sappan 10%
The present invention treats the preparation method of angina pectoris Chinese medicine preparation and takes following steps:
(1) get following raw material by weight percentage ready:
Radix Puerariae 1～50% Radix Salviae Miltiorrhizae 1～50% Radix Notoginseng 1～35%
Rhizoma Corydalis 1～35% Lignum Dalbergiae Odoriferae 1～30% Lignum Sappan 1～30%
(2) get that Lignum Dalbergiae Odoriferae, Lignum Sappan are pulverized, sieved, powdering is standby;
(3) get that Radix Puerariae, Radix Notoginseng, Rhizoma Corydalis decoct with water, concentrate, add ethanol precipitation, reclaim ethanol, to be condensed into the extractum shape standby;
(4) get that Radix Salviae Miltiorrhizae adds alcohol reflux, to filter, be condensed into the extractum shape standby;
(5) with the spissated two kinds of extractum mixing of above-mentioned difference, heating, add the standby Lignum Dalbergiae Odoriferae of pulverizing, the mixing of Lignum Sappan medicated powder, drying, sieve, granulate, make suitable preparation.
Decocting number of times in the described step (3) is 2～3 times, amount of water is 6～10 times of dose, time is 1～3 hour, it is 1.15～1.35 that its water extract is concentrated into relative density, add alcoholic acid quantity, making its concentration is 50～80%, and behind the recovery ethanol, concentrated extract to relative density is 1.15～1.35; Alcohol reflux is 2～3 times in the described step (4), and alcohol adding amount is 6～10 times of dose, and the time is 1～3 hour, and behind the recovery ethanol, concentrated extract to relative density is 1.15～1.35; Described Chinese medicine preparation of the present invention is any one in tablet, granule, the capsule, as syrup, granule, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not; Preferred capsule.
Described pharmaceutically acceptable additives are following one or more: glycerol, gelatin, Polyethylene Glycol, glycerol monolaurate (gelucire44/14), propylene glycol, dextrin, ethanol, dried starch, citric acid, sodium bicarbonate, ethyl hydroxybenzoate, tartaric acid, lecithin, sodium lauryl sulphate.
In order to illustrate characteristics of the present invention better,, further specify beneficial effect of the present invention below by elaboration to pharmaceutical composition clinical observation on the therapeutic effect of the present invention.
One, to the protective effect of Ischemia and Reperfusion in vivo in Rats myocardial damage
1, the variation of myocardial infarct size (animal model, method, testing index are slightly) the results are shown in Table 1
The variation of table 1 rat heart muscle infarction size
2, the change of cardiomyocyte apoptosis cell (animal model, method, testing index are slightly) the results are shown in Table 2
The variation of table 2 myocardial apoptosis cell quantity
Annotate: compare with matched group,
*P＜0.05,
*Compare with the invention group P＜0.01
ΔP＜0.05,
The Δ ΔP＜0.01
3, two groups of influences that improve hematological indices before and after the treatment
Table 3 liang group is improved the influence of hematological indices
Annotate: with ratio before and after the treatment of this group,
*P＜0.05,
*Ratio before and after group treatment of P＜0.01, two, #P＜0.05, ##P＜0.01
4, the curative effect of the two groups of blood fat reducing in treatment front and back, blood glucose relatively
The curative effect of table 4 liang group blood fat reducing, blood glucose is (X ± S relatively; Mmol/L)
Annotate: with ratio before and after the treatment of this group,
*P＜0.05,
*Ratio before and after group treatment of P＜0.01, two, #P＜0.05, ##P＜0.01
5, the bring high blood pressure down comparison of curative effect sees Table 5
The curative effect that table 5 liang group brings high blood pressure down relatively
Annotate: compare with this group treatment front and back,
*Compare #P＞0.05 before and after P＜0.01: two group of treatment
6, the dual regulation of Chinese medicine composition of the present invention sees Table 6
Table 6 Chinese medicine composition of the present invention is to the influence of blood pressure
As seen from the above table, the effect that Chinese medicine preparation of the present invention has two-ways regulation to blood pressure can make its reduction (P＜0.01) to the higher patient of blood pressure, and blood pressure patient on the low side is made its rising (＜0.05), and the patient then has no effect for normal arterial pressure.
7, two groups of curative effects relatively
Table 7 liang group curative effect relatively
The result shows that Chinese medicine preparation therapeutic effect of the present invention is better than matched group (P＜0.05).
Statistics shows that Chinese medicine preparation treatment group of the present invention and western medicine group all have the effect (P＜0.01) of remarkable reduction platelet aggregation rate, whole blood viscosity and plasma viscosity ratio.To these three indexs, though two groups of curative effects do not have significant difference, Chinese medicine composition of the present invention reduces packed cell volume and fibrinogenic effect obviously is better than matched group, and two groups have significant difference (P＜0.01 and P＜0.05).Moreover, Chinese medicine composition of the present invention has the effect that reduces serum cholesterol, is better than Western medicine group (P＜0.01), but for the reduction effect of triglyceride, does not have significant difference (P＞0.05).In addition, the effect (P＜0.05) that also has certain blood sugar lowering in the Chinese medicine composition of the present invention.In addition, the present invention have remarkable improve hemorheological property and bring high blood pressure down, the effect of blood fat, and find that it has the effect of two-ways regulation to blood pressure.Do not find any toxic and side effects in the observation.Prompting the present invention is a kind of more satisfactory medicine of prevention and treatment angina pectoris.
The specific embodiment
Enumerate embodiment below, further describe the present invention, but each embodiment does not limit the present invention.
Embodiment 1:
Take by weighing Radix Puerariae 100g, Radix Salviae Miltiorrhizae 100g, Radix Notoginseng 50g, Rhizoma Corydalis 50g earlier, Lignum Dalbergiae Odoriferae 30g, Lignum Sappan 30g are standby.With the Lignum Dalbergiae Odoriferae and the Lignum Sappan of recipe quantity pulverize, sieve, powdering is standby; Get Radix Notoginseng, Rhizoma Corydalis, Radix Puerariae decocts with water 2 times: be the water of 8 times of amounts for the first time, 2 hours time was the water of 6 times of amounts for the second time, the 1 hour time: collecting decoction, concentrate, add that ethanol makes its precipitation, reclaiming ethanol, to be concentrated into relative density be 1.15 extractum, standby; Getting Radix Salviae Miltiorrhizae again, with alcohol reflux 2 times, is the ethanol of 8 times of amounts for the first time, and 2 hours time was the ethanol of 6 times of amounts for the second time, 1.5 hours time: filter, reclaim ethanol, making its relative density is 1.15 extractum, standby; With twice respectively spissated extractum mixing, standby Lignum Dalbergiae Odoriferae is pulverized in adding and Lignum Sappan medicated powder mixes, and adds 85% ethanol, and drying makes the capsule that the present invention prevented and treated angina pectoris.
Embodiment 2
Get Radix Puerariae 150g, Radix Salviae Miltiorrhizae 150g, Rhizoma Corydalis 90g, Radix Notoginseng 90g, Lignum Sappan 60g, Lignum Dalbergiae Odoriferae 60g are standby; With the Lignum Sappan of Lignum Dalbergiae Odoriferae and recipe quantity pulverize, sieve, powdering is standby; Get Radix Notoginseng, Rhizoma Corydalis, Radix Puerariae decocts with water 2 times: be the water of 8 times of amounts for the first time, and 2 hours time, be the water of 10 times of amounts for the second time, the 1 hour time: collecting decoction, concentrate, add that ethanol makes its precipitation, reclaiming ethanol, to be concentrated into relative density be 1.20 extractum, standby: getting Radix Salviae Miltiorrhizae again with alcohol reflux 2 times, is the ethanol of 8 times of amounts for the first time, 2 hours time, be the ethanol of 6 times of amounts for the second time, the 1.5 hours time: filter, reclaim ethanol, making its relative density is 1.20 extractum, standby; With twice respectively spissated extractum mixing, standby Lignum Dalbergiae Odoriferae is pulverized in adding, Lignum Sappan medicated powder mixes, and adds 85% ethanol, and drying makes the tablet that the present invention prevented and treated angina pectoris.
Embodiment 3
Get Radix Puerariae 120g, Radix Salviae Miltiorrhizae 120g, Rhizoma Corydalis 60g, Radix Notoginseng 60g, Lignum Sappan 30g, Lignum Dalbergiae Odoriferae 30g are standby; With Lignum Dalbergiae Odoriferae, Lignum Sappan pulverize, sieve, powdering is standby; Radix Puerariae, Rhizoma Corydalis, the Radix Notoginseng of getting recipe quantity decoct with water 3 times: be the water of 10 times of amounts for the first time, 2 hours time, second and third time is the water of 9 times of amounts, and the time respectively is 1 hour; Collecting decoction, concentrate, add that ethanol makes its precipitation, reclaiming ethanol, to be concentrated into relative density be 1.30 extractum, standby; Getting Radix Salviae Miltiorrhizae alcohol reflux 3 times again, is the ethanol of 8 times of amounts for the first time, and 2 hours time, second and third time is the ethanol of 6 times of amounts, and the time respectively is 1.5 hours; Filter, reclaim ethanol, making its relative density is 1.30 extractum, standby; Twice respectively spissated extractum is mixed, and drying is sieved, and adds to pulverize standby Lignum Dalbergiae Odoriferae, Lignum Sappan medicated powder and mix and add 85% ethanol, and drying makes the granule of prevention of the present invention and treatment angina pectoris.
Claims (4)
1. treat the treating coronary heart disease and angina pectoris compositions for one kind, it is characterized in that: it is to be made by following raw materials by weight percent: Radix Puerariae 25% Radix Salviae Miltiorrhizae 25% Radix Notoginseng 20% Rhizoma Corydalis 20% Lignum Dalbergiae Odoriferae 10% Lignum Sappan 10%.
2. a kind of treatment treating coronary heart disease and angina pectoris preparation of compositions method according to claim 1 is characterized in that: take following steps:
(1) get following raw material by weight percentage ready:
Radix Puerariae 25% Radix Salviae Miltiorrhizae 25% Radix Notoginseng 20% Rhizoma Corydalis 20% Lignum Dalbergiae Odoriferae 10% Lignum Sappan 10%;
(2) get that Lignum Dalbergiae Odoriferae, Lignum Sappan are pulverized, sieved, powdering is standby;
(3) get that Radix Puerariae, Radix Notoginseng, Rhizoma Corydalis decoct with water, concentrate, add ethanol precipitation, reclaim ethanol, to be condensed into the extractum shape standby;
(4) get that Radix Salviae Miltiorrhizae adds alcohol reflux, to filter, be condensed into the extractum shape standby;
(5) with the spissated two kinds of extractum mixing of above-mentioned difference, heating, add the standby Lignum Dalbergiae Odoriferae of pulverizing, the mixing of Lignum Sappan medicated powder, drying, sieve, granulate, make suitable preparation.
3. a kind of treatment treating coronary heart disease and angina pectoris preparation of compositions method according to claim 2, it is characterized in that: decocting number of times in the described step (3) is 2～3 times, amount of water is 6～10 times of dose, time is 1～3 hour, it is 1.15～1.35 that its water extract is concentrated into relative density, adds alcoholic acid quantity, and making its concentration is 50～80%, after reclaiming ethanol, concentrated extract to relative density is 1.15～1.35; Alcohol reflux is 2～3 times in the described step (4), and alcohol adding amount is 6～10 times of dose, and the time is 1～3 hour, and behind the recovery ethanol, concentrated extract to relative density is 1.15～1.35.
4. a kind of treatment treating coronary heart disease and angina pectoris compositions according to claim 1, it is characterized in that: its dosage form is tablet, granule or capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510061809 CN1813892B (en) | 2005-12-05 | 2005-12-05 | Medicinal composition for treating coronary disease and angina pectoris and its use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510061809 CN1813892B (en) | 2005-12-05 | 2005-12-05 | Medicinal composition for treating coronary disease and angina pectoris and its use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1813892A CN1813892A (en) | 2006-08-09 |
| CN1813892B true CN1813892B (en) | 2011-06-15 |
Family
ID=36906324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510061809 Expired - Fee Related CN1813892B (en) | 2005-12-05 | 2005-12-05 | Medicinal composition for treating coronary disease and angina pectoris and its use |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1813892B (en) |
-
2005
- 2005-12-05 CN CN 200510061809 patent/CN1813892B/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 翁维良.冠心病血瘀证的研究进展.《中医杂志》.1987,(第6期),64-67. * |
| 翁维良.冠心病血瘀证的研究进展.<<中医杂志>>.1987,(第6期),64-67. |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1813892A (en) | 2006-08-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101011561B (en) | Modern traditional Chinese medicine oral preparation huanglianwendan decoction and production method thereof | |
| CN101612362B (en) | Complex preparation for regulating lipid and preventing and curing heart cerebrovascular diseases and preparation method thereof | |
| CN1931261B (en) | Blood pressure and blood lipid lowering capsule and its preparation process | |
| CN104208302A (en) | Fructus rosae laevigatae healthy oral solution for reducing blood fat and preparation method thereof | |
| WO2018099216A1 (en) | Traditional chinese medicine composition for treating atherosclerosis-caused hypertension and application thereof | |
| CN102579836B (en) | Traditional Chinese medical dendrobium huoshanense composition and preparation method thereof | |
| CN101524469A (en) | Chinese herbal medicine compound preparation for treating congestive heart failure and preparation method thereof | |
| CN101518595A (en) | Medical composition with functions of lowering lipid, reducing fat and oxidation resistance and preparation method thereof | |
| CN104857154A (en) | Traditional Chinese medicine composition for treating three-high diseases and preparation method therefor | |
| CN102526423A (en) | Medicine composition for treating ischemic heart disease | |
| CN101172155A (en) | Novel dosage forms of pulse-activating gallbladder warming soup and method of preparing the same | |
| CN102028746A (en) | Drug for treating coronary heart disease and extraction method | |
| CN105687788A (en) | Pharmaceutical composition capable of softening blood vessels and application thereof | |
| CN104645015A (en) | Traditional Chinese medicine compound preparation for treating vascular dementia and preparation method of traditional Chinese medicine compound preparation | |
| CN102028747A (en) | Drug for treating coronary heart disease and extraction method | |
| CN1813892B (en) | Medicinal composition for treating coronary disease and angina pectoris and its use | |
| CN104027525A (en) | Drug for treatment of ischemic heart disease, preparation method and application thereof | |
| CN1182864C (en) | Medicine for vascular denmentia disease and preparation method | |
| CN104740054A (en) | Pharmaceutical composition for treating myocardial ischemia as well as preparation method and use of pharmaceutical composition | |
| CN1275590C (en) | Dispersion tablet containing ginkgo leaf extract | |
| CN105169187B (en) | A kind of composition and its application, preparation method and drug, food containing the composition | |
| CN104257755A (en) | Composition with effect of treating diabetes as well as preparation method and application of composition | |
| CN101129430A (en) | Traditional Chinese medicine composition used for preventing and controlling cardiovascular disease, processes for producing same and application of the same | |
| CN103611051A (en) | Traditional Chinese medicinal preparation for preventing and treating coronary heart disease and preparation method thereof | |
| CN103055122A (en) | Medicine for preventing restenosis after intracoronary stent implantation and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110615 Termination date: 20131205 |