CN1812975A - 制备二芳基脲化合物的方法 - Google Patents

制备二芳基脲化合物的方法 Download PDF

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Publication number
CN1812975A
CN1812975A CNA2004800184368A CN200480018436A CN1812975A CN 1812975 A CN1812975 A CN 1812975A CN A2004800184368 A CNA2004800184368 A CN A2004800184368A CN 200480018436 A CN200480018436 A CN 200480018436A CN 1812975 A CN1812975 A CN 1812975A
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CN
China
Prior art keywords
alkyl
formula
alkoxy
compound
hours
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800184368A
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English (en)
Chinese (zh)
Inventor
尼扎尔·哈达德
魏旭东
克里斯·H·塞纳纳亚克
徐景华
内森·伊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharmaceuticals Inc
Publication of CN1812975A publication Critical patent/CN1812975A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2004800184368A 2003-06-30 2004-06-11 制备二芳基脲化合物的方法 Pending CN1812975A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48372003P 2003-06-30 2003-06-30
US60/483,720 2003-06-30

Publications (1)

Publication Number Publication Date
CN1812975A true CN1812975A (zh) 2006-08-02

Family

ID=34061980

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800184368A Pending CN1812975A (zh) 2003-06-30 2004-06-11 制备二芳基脲化合物的方法

Country Status (6)

Country Link
US (1) US7265222B2 (enExample)
EP (1) EP1644341A1 (enExample)
JP (1) JP2007518680A (enExample)
CN (1) CN1812975A (enExample)
CA (1) CA2530776A1 (enExample)
WO (1) WO2005005396A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8563115B2 (en) * 2008-08-12 2013-10-22 Xerox Corporation Protective coatings for solid inkjet applications
US8191992B2 (en) 2008-12-15 2012-06-05 Xerox Corporation Protective coatings for solid inkjet applications
CN105408315B (zh) 2013-04-02 2018-09-14 瑞斯比维特有限公司 激酶抑制剂
CN113717162A (zh) 2013-12-20 2021-11-30 奥苏拉收购有限公司 用作激酶抑制剂的脲衍生物
MA40775A (fr) 2014-10-01 2017-08-08 Respivert Ltd Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38
CA3015978A1 (en) 2016-04-06 2017-10-12 Topivert Pharma Limited Kinase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005507367A (ja) * 2001-04-13 2005-03-17 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド １，４−二置換ベンゾ縮合化合物
MXPA03010487A (es) * 2001-05-16 2004-03-09 Boehringer Ingelheim Pharma Derivados de diarilurea utiles como agentes antiinflamatorios.
JP2006504667A (ja) * 2002-08-08 2006-02-09 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 炎症過程に関与するサイトカインの抑制剤としてのフッ素化フェニル−ナフタレニル−尿素化合物

Also Published As

Publication number Publication date
WO2005005396A1 (en) 2005-01-20
EP1644341A1 (en) 2006-04-12
US20040266767A1 (en) 2004-12-30
JP2007518680A (ja) 2007-07-12
CA2530776A1 (en) 2005-01-20
US7265222B2 (en) 2007-09-04

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