CN1792360A

CN1792360A - Formula of oral protecting liquor

Info

Publication number: CN1792360A
Application number: CN 200510101723
Authority: CN
Inventors: 林镇顺
Original assignee: Individual
Current assignee: Individual
Priority date: 2005-12-01
Filing date: 2005-12-01
Publication date: 2006-06-28

Abstract

A nursing liquid of oral cavity for killing bacteria, relieving inflammation, refreshing oral cavity, preventing decayed tooth and odontolith, etc contains hibitane (0.1%), zinc citrate (0.15%), strontium chloride (0.2%) and sodium monofluorophosphate.

Description

Formula of oral protecting liquor

Affiliated technical field

The invention belongs to field of oral care, is a kind of formula of oral protecting liquor specifically.

Background technology

Also do not find to have similar technical formula of the present invention at present.

Summary of the invention

Make oral nursing liquid have functions such as bactericidal antiphlogistic, oral cavity fresh and cool, elimination halitosis, desensitization analgesia, anti-caries, anti-calculus, functions of whitening teeth.

In order to make oral nursing liquid possess above-mentioned merit, the component prescription that the present invention adopts is: formula material is divided into four components, and is specific as follows:

(1) raw material grouping

Composition A:

1, sodium lauryl sulphate (2.5%)

2, zinc citrate (0.15%)

3, strontium chloride (0.2%)

4, glycine (0.1%)

5, sodium benzoate (0.15%)

6, sodium monofluorophosphate (0.5%)

7, aspartame (0.06%)

8, acesulfame potassium (0.06%)

9、PVP (1％)

Composition B:

1, soil temperature---80 (0.1%)

2, glycerol (3%)

3, sorbitol (10%)

Composition C:

1,95% ethanol (edible ethanol) (10%)

2, left-handed menthol (0.5%)

3, Mentha piperita (0.2%)

4, eucalyptus oil (Eucalyptus globulus Labill) (0.2%)

5, modulation essence (0.2%)

Components D:

1, hibitane (0.1%)

2, deionized water 770ml (pressing 1000ml stock solution)

Functional component, content in the prescription

1, hibitane 0.1%

2, zinc citrate 0.15%

3, strontium chloride 0.2%

4, sodium monofluorophosphate 0.5%

(2) concrete method for making:

D heats earlier, keeps 50 ℃ of constant temperature, A is formed to divide add among the D, adds B then and forms branch, mixes 30-40 minute under 50 ℃ of constant temperature; Add C when being cooled to 30 ℃ and form branch, continued then to mix 20 minutes.Preparation finishes, and stock solution is inserted airtight ageing 2 days (preferably temperature is controlled at below 10 ℃) in the storage tank.Filtration, canned then.

(annotate: if mixing plant possesses refrigerating function, production equipment is abundant simultaneously, also can carry out ageing in agitation mixer)

Product efficacy and functional component are summarized as follows:

1, bactericidal antiphlogistic, oral cavity fresh and cool, elimination halitosis:

Periodontitis owing to local diseases such as dental calculus because of and the general cause of disease such as nutrition, endocrine, digestive system disease cause.The symptom of periodontitis is generally in the tooth red, swollen, hemorrhage, also can come to a head when serious, and odontoseisis can appear in the periodontal disease aggravation.

Due to the disease of existing systemic disease of the reason of halitosis such as respiratory tract, digestive system, also have locality oral disease and unhygienic due to.Antibacterial in the oral cavity can make protein and peptide metabolism, decomposition,, produce volatile sulfur compoundses such as hydrogen sulfide and methanthiol.Organic acid and nitride also are that the one-tenth that causes halitosis divides it in addition.

Hibitane has comparatively wide antimicrobial spectrum, for Gram-positive, negative bacterium, fungus bactericidal action is arranged all, can also suppress the Streptococcus mutans synthesis of glucose, forms effectively for suppressing bacterial plaque simultaneously.

Hibitane is widely used in preventing and treating periodontal (gingivitis, periodontitis, periodontal abscess, halitosis), dental caries, oral mucosa disease.

2, desensitization analgesia:

Hyperesthesia of dentin is a department of stomatology common disease, and its generation mechanism is not fully aware of as yet, and Therapeutic Method is a lot of clinically, and short-term is effective, and is at a specified future date not good enough.Tooth is met hot and cold, sour, sweet and stimulations such as machinery just feel to ache during its symptom.Dentin hypersensitiveness's history is because dentin exposes, dentinal tubule's opening causes.Reducing Dentinal permeability and be the theoretical foundation of treatment dentin hypersensitiveness, mainly is the development tooth to the anaphylaxis pain of appearance such as hot and cold, sour, sweet.

The strontium ion of strontium chloride can be absorbed by dentium nitor, dentin, generate precipitate such as strontium carbonate, Strontium hydrate., can reduce the permeability of dental hard tissue, improve the cushioning effect of dental tissue, reducing gum edge periodontal tissue stimulates as sour, sweet, hot and cold ground sensitivity poisonous substance and other, reaches the desensitization analgesic effect.Strontium can combine, strengthen the diseases prevention ability of dental tissue again closely with periodontal tissue, reaches desensitization effect.

3, anti-caries

The pathogenic factor of dental caries is unclear fully as yet so far, but generally believes in the process of the carbohydrate that is antibacterial in decomposing food and produced acid, thereby makes due to the tooth decalcification.World Health Organization (WHO) classifies dental caries as the third-largest disease that needs keypoint control after cardiovascular diseases and the cancer.According to statistics, there is at present 90% people to suffer from various degree dental caries in the world approximately.Dental caries is second largest in the world pandemic, is only second to Common Cold.Think at present, the streptococcus mutant body of dental caries pathogen, be subjected to being distributed in the effect of the part glucosyl transferase of surface layers of bacteria, synthesized water insoluble and sticking glucosan from sucrose, be bonded at securely on the tooth, produce lactic acid by various carbohydrates again but the tooth enamel damage.

Therefore, the prevention method of dental caries generally can be considered following 3 kinds: the acid resistance of a, enhancing tooth; B, kill the dental caries pathogen; The dextran that c, decomposition streptococcus mutant body produce perhaps stops synthesizing of dextran etc.

Fluoride can strengthen the tooth acid resistance, and dominant mechanism is hydroxyapatite and the fluorion displacement that causes tooth enamel, becomes the high fluoridated apatite of acid resistance.The fluorine of high concentration can form the calcium fluoride fine particle and can keep more than 24 hours at enamel surface, even the longer time.These calcium fluoride granules have constituted the plain warehouse of fluorine between bacterial plaque and enamel.Use every day 1-2 fluorine-containing oral-cavity article just can keep the deposition of bacterial plaque dental enamel surface fluorination calcium.Suppress enamel decalcification, promote the incipient dental caries remineralization, thereby play the effect of caries prevention.

It was reported that the toothpaste that has used fluoride is 15-30% to the control rate of dental caries.

4, anti-calculus, functions of whitening teeth:

Dental calculus is to be deposited and formed by the calcium that the Organic substances such as dental plaque that are attached on the tooth run in the saliva.Tartar is the main local factor that causes periodontal, and tartar extensively exists in population of China.

Dental exogenous mottle is owing to drink the beverage that contains pigment, ediblely have the food of pigment and smoking to cause.Dental exogenous mottle is common in the crowd, influence is attractive in appearance.

Zinc citrate can suppress the calcification of bacterial plaque effectively, control gingivitis, dental calculus, dental hemorrhage and dental caries.Normal and the composite use of fluoride, this is because the chemical composition of dental calculus is similar to enamel, and the medicine of removing dental calculus is not answered damage tooth, and fluorine can make the enamel remineralization, so fluoridize is a protective measure.Unite use for a long time and can prevent the formation of dental calculus.Can also make established dental calculus become flexible gradually, peel off.

Simultaneously, zinc citrate can be detained in the gingival sulcus and discharges gradually, in the formation that stops dental calculus, suppresses pigments such as smoking patch, tea speckle and adheres at dental surface, thereby reach the effect of functions of whitening teeth.

In addition, in view of the most of geographic child of China has the zinc deficiency phenomenon, and zinc citrate has been proved to be the naturally occurring physiologically substance of human body, and the many physiological activities and the growth of children of human body had very important effect; And have that zinc content height (greater than 30%), buccal absorption are fast, free from extraneous odour, characteristics such as without any side effects, so zinc citrate is comparatively ideal organic zinc supplement agent at present.

The beneficial effect that the present invention produced is: make oral nursing liquid have functions such as bactericidal antiphlogistic, oral cavity fresh and cool, elimination halitosis, desensitization analgesia, anti-caries, anti-calculus, functions of whitening teeth.

Accompanying drawing:

Fig. 1 is a process chart of the present invention.

Specific embodiment:

Formula material is divided into four components, and is specific as follows:

The raw material grouping

Composition A:

1, sodium lauryl sulphate (2.5%)

2, zinc citrate (0.15%)

3, strontium chloride (0.2%)

4, glycine (0.1%)

5, sodium benzoate (0.15%)

6, sodium monofluorophosphate (0.5%)

7, aspartame (0.06%)

8, acesulfame potassium (0.06%)

9、PVP (1％)

Composition B:

1, soil temperature---80 (0.1%)

2, glycerol (3%)

3, sorbitol (10%)

Composition C:

1,95% ethanol (edible ethanol) (10%)

2, left-handed menthol (0.5%)

3, Mentha piperita (0.2%)

4, eucalyptus oil (Eucalyptus globulus Labill) (0.2%)

5, modulation essence (0.2%)

Components D:

1, hibitane (0.1%)

2, deionized water 770ml (pressing 1000ml stock solution)

Functional component, content in the prescription

1, hibitane 0.1%

2, zinc citrate 0.15%

3, strontium chloride 0.2%

4, sodium monofluorophosphate 0.5%

Concrete method for making:

Claims

1. a formula of oral protecting liquor is made up of four kinds of components, and it is characterized in that: each component ratio is: composition A:

1, sodium lauryl sulphate (2.5%)

2, zinc citrate (0.15%)

3, strontium chloride (0.2%)

4, glycine (0.1%)

5, sodium benzoate (0.15%)

6, sodium monofluorophosphate (0.5%)

7, aspartame (0.06%)

8, acesulfame potassium (0.06%)

9、PVP (1％)

Composition B:

1, soil temperature--80 (0.1%)

2, glycerol (3%)

3, Pyrusussuriensis (10%)

Composition C:

1,95% ethanol (edible ethanol) (10%)

2, left-handed menthol (0.5%)

3, Mentha piperita (0.2%)

4, eucalyptus oil (Eucalyptus globulus Labill) (0.2%)

5, modulation essence (0.2%)

Components D:

1, hibitane (0.1%)

2, deionized water 770ml (pressing 1000ml stock solution).

2. formula of oral protecting liquor according to claim 1, its technology is made flow process and is characterised in that: D heats earlier, keeps 50 ℃ of constant temperature, A is formed to divide add among the D, adds the B composition then and divides, and mixes 30-40 minute under 50 ℃ of constant temperature; Add C when being cooled to 30 ℃ and form branch, continued then to mix 20 minutes.Preparation finishes, and stock solution is inserted airtight ageing 2 days (preferably temperature is controlled at below 10 ℃) in the storage tank.Filtration, canned then.