CN1791375A - Multiphase toothpaste composition - Google Patents
Multiphase toothpaste composition Download PDFInfo
- Publication number
- CN1791375A CN1791375A CNA2004800132908A CN200480013290A CN1791375A CN 1791375 A CN1791375 A CN 1791375A CN A2004800132908 A CNA2004800132908 A CN A2004800132908A CN 200480013290 A CN200480013290 A CN 200480013290A CN 1791375 A CN1791375 A CN 1791375A
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- China
- Prior art keywords
- phase
- opaque
- mutually
- toothpaste
- gel
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
A multiphase toothpaste comprising an opaque phase and a transparent gel phase, each said phase having a mobile phase with an effective amount of cleansing or polishing agents suspended therein, and wherein of the ingredients making up more than 2% of each mobile phase a corresponding amount of said ingredients is present in the other mobile phase such that no substantial transfer of ingredients occurs between the mobile phases.
Description
The present invention relates to multiphase toothpaste, particularly have good cleaning, polishing and pure and fresh characteristic comprise clear gel mutually with the heterogeneous stable toothpaste of opaque combination mutually.
Comprise gel (transparent) mutually with opaque (opaque) multiphase toothpaste mutually commercial attractive, and increase the captivation of product usually to consumer.
GB 1271944 discloses the toothpaste that comprises transparent or semitransparent gel main body and be contained in the less important part of the cleaning agent of main body and buffing compound to small part.Yet this multiphase toothpaste with commercial appeal is having certain disadvantages aspect cleaning of teeth or the tooth polishing characteristic.Can know that from this patent the gel main body that mentioned toothpaste comprises is used for aesthetic purposes, but show bad effect, because the gel main body must not contain the cleaning agent/buffing compound that influences the gel transparent characteristic for cleaning and polishing.Therefore, the toothpaste that satisfies the aesthetic requirement of multiphase toothpaste has limitation in effectively cleaning and polishing properties, and this is because cleaning agent and buffing compound are incorporated into due to the limitation in the main body gel phase.
EP application 0076563 has proposed the multiphase toothpaste of another kind of improvement cleaning and polishing characteristic, and this toothpaste is made up of the main body of the opaque and white paste substrate that comprises desired cleaning agent and buffing compound and a small amount of less important part that gel phase is formed.It should be noted that, the combination of mentioning among the configuration of the multiphase toothpaste of mentioning in EP ｀ 563 and the GB 1271944 is just the opposite, thereby uses the opaque main body of the cleaning agent can comprise a large amount more and buffing compound and a spot ofly have circumscribed less important gel phase and obtain better cleaning or polishing effect incorporating this class cleaning agent and buffing compound into by suggestion.
From the above, though above-mentioned EP heterogeneous agent has obtained better cleaning and polishing characteristic, same in essence suggestion has the opaque phase of main body of higher levels of cleaning agent/buffing compound and proposes usually and the inconsistent material of the less important part of gel (for example the acceptable abrasive material of tooth etc.) is contained in the opaque paste substrate.
Except the limitation that in gel phase, adds cleaning agent/buffing compound, find that also multiphase toothpaste faces stability problem, particularly adding dyestuff/color/flow into bleeding problem of timesharing, promptly spread between gel phase and opaque phase/undesirable interaction, this will cause the forfeiture of aesthetic values and captivation.
For avoiding this class diffusion/undesirable interaction between gel phase and opaque phase, EP ' 563 further proposes the coupling of out of phase pH value.
On the other hand, penetrate into the problem of white solvent for fear of coloured material from the strip component, the two component dentifrice preparations that US 4814160 has proposed to be different in essence.Particularly this patent proposes organic pigment with gel component of forming as the xanthan gum of unique gel and the white component that is selected from the card uncle carrageenin mixture in the visibly different liquid-carrier, and this liquid-carrier comprises the acceptable buffing compound of different teeth.
US 5989870 discloses the another kind of heterogeneous Dentrifice composition that contains the herbal drug extract, and said composition comprises striped and transfers to basic components to avoid on separating surface coloring agent from colouring component (striped).
Existing multiphase toothpaste technology shows, when consumer demand requires this class multiphase toothpaste especially by using gel phase and opaque combined when giving toothpaste with aesthetic feeling and visual attraction, because thereby incorporating buffing compound and cleaning agent into the gel phase restriction, restriction from this class heterogeneous agent, obtains desired cleaning and polishing effect, thereby also because gel phase need be restricted on a small quantity/less importantly incorporate the opaque phase of main body into promotion buffing compound/cleaning agent and limited and obtain various gel phases with visual attraction-opaque combined.Simultaneously, above-mentioned state-of-art has disclosed the bleeding problem of color/dyestuff from one to another phase, need to adopt diverse gel phase to avoid the problem of this species diversity with opaque preparation mutually and/or uses herb extract optionally to control the bleeding of multiphase toothpaste.
Therefore elementary object of the present invention provides multiphase toothpaste, for example opaque phase and clear gel combination mutually, this be combined in each when keeping desired stability mutually selection/the adding to activating agent/additive have more motility.
Another target of the present invention provides the multiphase toothpaste that comprises opaque phase and clear gel combination mutually, cleaning and polishing characteristic that this combination can be avoided adding the above-mentioned prior art restriction of buffing compound and cleaning agent in gel phase and therefore improve this class multiphase toothpaste.
Another target of the present invention provides stable multiphase toothpaste, this toothpaste can keep desired cleaning/polishing characteristic on the one hand, can avoid limiting gel phase on the other hand and provide desired motility as the limitation (because adding problem of cleaning agent and buffing compound) of the less important preparation of toothpaste and the various forms (containing gel phase is about 50% volume/volume or more) that therefore acquisition had a multiphase toothpaste of aesthstic attractive force.
Another target of the present invention is to obtain to provide good freshness in desired cleaning/polishing by gel section and the opaque section that abrasive material is joined toothpaste preparation.
Another target of the present invention is the multiphase toothpaste of cost efficient, and this multiphase toothpaste provides desired motility and given desired independence to each effective efficiency, cleaning and polishing characteristic mutually simultaneously with selecting the level of each tooth activating agent/abrasive material in mutually.
Another target is a gel phase--the opaque mutually biphase toothpaste that distributes side by side, this toothpaste satisfy the target of the better aesthetic feeling of multiphase toothpaste and consumer's captivation and have also obtained good cleaning/polishing characteristic not requiring under the opaque main body situation of (surpassing 60% volume/volume).
The further target of the present invention is the development of multiphase toothpaste, this multiphase toothpaste comprise the gel phase that can be used as activating agent/composition that commercial toothpaste generally adopts and have desired stability and avoid flowable component cause in alternate diffusion/migration toothpaste contaminated in storage process/problem of the loss of desired aesthstic attractive force.
Thereby basic sides according to the present invention provides the multiphase toothpaste of claim 1.
In above-mentioned multiphase toothpaste composition of the present invention, each described gel phase comprises its liquid contents and its soluble component with opaque mobile phase in mutually.
For the sake of clarity, content is represented as the main mobile phase composition of term greater than those mobile phase compositions of 2% in the mobile phase.
Term of the present invention is transparent to be meant that compositions has the desired transmitance of the measured light of technology as described below by the sample of compositions.The transmitance of sample on Shimadzu 1601 spectrophotometers (revise assembling 1/4 " colorimetric pool) 1/4 " record in the colorimetric pool.Employed optical wavelength is 400-800nm.The transmitance of sample is measured as object of reference with distilled water.Transmitance is preferably greater than 2 greater than 1, more preferably greater than 5, further is called as transparent more preferably greater than 10 sample.The transmitance of translucent sample of using above-mentioned commercial measurement is less than 1.
The main mobile phase composition of the mobile phase of each described opaque phase/gel phase of preferred especially heterogeneous combination does not have substantial difference, and promptly they reach balance so that at final products any substantial transfer do not take place between phase and phase.
Therefore mobile phase can comprise the liquid that is selected from the conventional liq composition, and described conventional liq composition is selected from wetting agent, foaming agent, spice, polymer and water.
Equally, the soluble component in the mobile phase can comprise sweetener, wetting agent, structural agent, binding agent, buffer agent, foaming agent, antiseptic and tooth activating agent.
Gel phase is 20 to 95% w/w with opaque mobile phase mutually, preferred 30 to 90% w/w.
Importantly, because the gel phase in the heterogeneous agent of the present invention and the above-mentioned optionally essence proportioning of opaque main mobile phase constituent concentration mutually, might obtain to comprise the heterogeneous agent of gel phase now on the one hand, described gel phase can comprise abrasive material and also therefore give the cleaning of the gel phase except that deriving from opaque cleaning/polishing mutually and polish effect with other cleaning agent and/or buffing compound.Previous only be used for aesthstic target substantially and therefore preferably only except that being used for aesthstic target, also can provide desired cleaning and polishing active as selectivity heterogeneous agent of the present invention now, thereby improve the cleaning and the polishing activity of this class multiphase toothpaste as the gel phase of a small amount of less important part.
According to the above, the gel phase in the preparation of the present invention comprises the abrasive material of the 4-40% that accounts for gel phase weight, the wetting agent of 1-90%, the sweetener of 0-2%, the foaming agent of 0-5%, the thickening agent of 0-20%, the binding agent of 0.1-25% and the water of surplus.Gel phase also can comprise the tooth activating agent of effect level and perfume compound so that freshness to be provided.
The opaque abrasive material of the 4-70% that accounts for opaque phase weight, the wetting agent of 1-90%, the sweetener of 0-2%, the foaming agent of 0-5%, the thickening agent of 0-20%, the binding agent of 0.1-25% and the water of surplus of comprising mutually.The opaque tooth activating agent that also can comprise effect level mutually.
Thickening agent, dyestuff, antiseptic and spice etc. can add according to the technical specification of product.
The content of each described gel phase/opaque mobile phase in mutually can preferably comprise: 1 to 90% wetting agent, 0.1 to 40% binding agent, 0 to 5% foaming agent, 0 to 2% spice, 0 to 5% buffer agent, proper amount of activating agent, water to 100.
Abrasive material is optional from Chalk, silicon dioxide or other known abrasive materials and their combination.Suitable bonding comprises sodium carboxymethyl cellulose, carrageenin, xanthan gum, guar gum, polymer and their combination.
According to preferred aspect of the present invention, provide to comprise clear gel phase and opaque both multiphase toothpastes side by side mutually, described clear gel accounts for 40 to 60% volume/volume mutually, and preferred 44 to 50%; Described opaque 40 to 60% volume/volume that account for mutually, preferred 50 to 56%, wherein each describedly has the cleaning agent/buffing compound of effective dose mutually and comprises mobile phase, and the difference that the main mobile phase composition of the described mobile phase of the described opaque phase/gel phase of each of heterogeneous combination is chosen as between different opaque phase/gel phases is not more than 50%.
Therefore the opaque combination and the configuration mutually of various gel phases that may obtain to have desired stability and cleaning/polishing characteristic and desired effect.
According to another aspect of the present invention, gel phase to the small part that comprises of multiphase toothpaste be contained in opaque mutually in.
Therefore may obtain in this case described as core by a phase in another form of surrounding mutually, each can be selected from opaque phase or clear gel phase mutually.Perhaps gel phase can comprise part and is contained in opaque striped in mutually, and the part surface of described striped is exposed to the surface of main body.
Importantly, in above disclosed multiphase toothpaste of the present invention, during toothpaste preparation has obtained desired two or more steady-state conditions that is maintained at them mutually on the one hand even has stored, except the aesthstic target that is used for multiphase toothpaste, do not stand some particularly restrictions of the inadequate cleaning of gel phase and polishing characteristic mutually on the other hand.In other words, each phase of multiphase toothpaste of the present invention, promptly gel phase or opaque itself be enough to mutually as effective cleaning and the polishing medium, thereby in the use of this class preparation, provide desired cleaning and the polishing effect.
In addition, mobile phase (being liquid phase) by keeping each phase and wherein molten composition consistent or basic identical, can avoid the infiltration of content/composition from one to another phase and/or the problem of oozing out on the one hand, help keeping each enough mutually cleaning own and polishing characteristic on the other hand, all the more so under the situation that adds abrasive material.
Except above-mentioned advantage, the above-mentioned balance of mobile phase provides motility to the selection of each mobile phase in mutually and insoluble matter wherein and may avoid the high liquid of use cost (for example wetting agent, spice) and substitute with the abrasive material (for example Chalk) of cost efficient.Therefore the invention provides the heterogeneous dentifrice formulation of cost efficient with good cleaning/polishing characteristic.
People also find in the keeping of above-mentioned even liquid phase, and the content of each phase makes it might add effective cleaning and polishes the beneficial agent (for example abrasive material) of desired recruitment and do not damage the aesthstic attractive force of this gellike based formulation.
The manufacture method of multiphase toothpaste of the present invention comprises the conventional manufacturing technology of multiphase toothpaste, for example is used to obtain optionally that gel phase-opaque phase makes up side by side, two with side by side/mode of complex form co-extrusion provides.For making the striated multiphase toothpaste, can use conventional fringe technique and toothpaste dispensing device.
Details of the present invention, its target and advantage are being described in more detail below in conjunction with the non-restrictive illustrative explanation.
Embodiment
Embodiment 1
In this embodiment, multiphase toothpaste of the present invention comprise 50: the 50 opaque phase of (volume/volume): the combination of gel phase.Below table 1 described in detail each mutually in employed selectivity composition.Importantly, the above-mentioned selectivity composition that is used for the gel phase of heterogeneous (50: 50) preparation and opaque phase is elected as according to the present invention and is had identical in fact mobile phase concentration.The mobile phase of using in the preparation of the present invention (being gel phase and the opaque liquid and the solubility content of each total phase mutually) is listed in the table 1 as following:
Table 1
Opaque phase
| Opaque phase percetage by weight % | Mobile phase percetage by weight % | |
| 70% sorbitol solution (aqueous solution) | 43.0 | 79.0 |
| Polyethylene Glycol (PEG) 1500 | 1.3 | 2.4 |
| Sodium lauryl sulphate (SLS) | 1.8 | 3.2 |
| Chalk | 40.0 | - |
| Silicon dioxide thickening agents | 5.0 | - |
| Water | 5.8 | 10.6 |
| Other microcomponent | 3.1 | To 100 |
Gel phase
| Gel phase percetage by weight % | Mobile phase percetage by weight % | |
| 70% sorbitol solution | 66.0 | 79.0 |
| PEG1500 | 2.0 | 2.4 |
| SLS | 2.7 | 3.2 |
| Abrasive silica | 8.0 | - |
| Silicon dioxide thickening agents | 8.4 | - |
| Water | 8.8 | 10.6 |
| Other microcomponent | 4.1 | To 100 |
The following comparing embodiment of the form placed side by side of the opaque preparation of the clear gel preparation of biphase preparation of the present invention and existing conventional and routine compares.
Comparative Example A An:
Among this embodiment, conventional gel and opaque toothpaste preparation are with form filling side by side.Gel phase in the said preparation is different in essence mobile phase with opaque content mutually in biphase, as shown in table 2 below.
Table 2:
Opaque phase
| Opaque phase percetage by weight % | Mobile phase percetage by weight % | |
| 70% sorbitol solution | 15.0 | 27.3 |
| Polyethylene Glycol (PEG) 1500 | 0 | 0 |
| Sodium lauryl sulphate (SLS) | 2.5 | 4.6 |
| Chalk | 40.0 | - |
| Silicon dioxide thickening agents | 5.0 | - |
| Water | 32.8 | 59.8 |
| Other microcomponent | 4.7 | To 100 |
Gel phase
| Gel phase percetage by weight % | Mobile phase percetage by weight % | |
| 70% sorbitol solution | 66.0 | 79.4 |
| PEG1500 | 2.0 | 2.4 |
| SLS | 2.8 | 3.4 |
| Abrasive material and silicon dioxide thickening agents | 16.9 | - |
| Water | 10.6 | 12.1 |
| Other microcomponent | 1.7 | To 100 |
Embodiment 2
Among this embodiment, the opaque phase of (volume/volume) that multiphase toothpaste of the present invention comprises 50: 50: the combination of gel phase.Each mutually used selectivity composition sees following table 3 for details.Importantly, the above-mentioned selectivity composition of gel phase in heterogeneous (50: 50) preparation and the opaque phase difference of main mobile phase composition between different opaque phase/gel phases of electing each the described opaque phase/gel phase that makes heterogeneous combination according to the present invention as is no more than 35%.Those mobile phase concentration in mutually of opaque phase and clear gel compositions and each mutually see Table 3:
Table 3
Opaque phase
| Opaque phase percetage by weight % | Mobile phase percetage by weight % | |
| 70% sorbitol solution | 38.0 | 71.8 |
| Polyethylene Glycol (PEG) 1500 | 1.3 | 2.5 |
| Sodium lauryl sulphate (SLS) | 2.0 | 3.8 |
| Sodium silicate | 1.8 | 3.4 |
| Chalk | 42.0 | - |
| Abrasive silica | 4.6 | - |
| Water | 6.9 | 13.0 |
| Other microcomponent | 3.4 | To 100 |
Gel phase
| Gel phase percetage by weight % | Mobile phase percetage by weight % | |
| 70% sorbitol solution | 65.0 | 77.2 |
| PEG1500 | 2.0 | 2.4 |
| SLS | 2.7 | 3.6 |
| Sodium silicate | 2.5 | 3.0 |
| Abrasive silica | 15.8 | - |
| Water | 8.5 | 10.0 |
| Other microcomponent | 3.5 | To 100 |
Multiphase toothpaste sample of the present invention (embodiment 1 and 2) and Comparative Example A An are come stable testing according to transparency and other user's character (for example in the compressibility of storage period from pipe).Test data is summarized in table 4.
Table 4
| Embodiment 1 | Embodiment 2 | Comparative Example A An | |
| The compressibility of coextrusion sample (after in pipe, storing 7 days) | Good | Good | Sample is stone, and is incompressible |
| Cleaning and polishing characteristic | Good | Good | - |
| The transmitance value of gel phase (the 1st day) | 13.5 | 13.5 | 18 |
| The transmitance value of gel phase (storing after 3 months) | 11.0 | 10.5 | 0.1 |
By as seen above-mentioned, comprising gel phase provides greater flexibility so that beneficial agent (particularly abrasive material) is joined in the preparation of the present invention with the opaque selectivity heterogeneous agent of the present invention (embodiment 1 and 2) of (gel phase and the opaque mobile phase composition that has selected concentration mutually) mutually, and said preparation demonstrates good cleaning and polishes effect and keep stability of formulation.Importantly, find that another does not contain the heterogeneous agent of the equilibrated mobile phase of this class (Comparative Example A An) and does not obtain desired preparation stability.
Therefore may obtain various gel phases-opaque combined stable multiphase toothpaste according to the present invention, wherein each itself is enough to provide desired cleaning and polishing effect mutually.Importantly, the clear gel that can comprise abrasive material now not only promotes the aesthstic attractive force of multiphase toothpaste mutually, and helps to obtain desired cleaning and polishing effect.Importantly, the concentration of the soluble component in opaque phase and the gel phase preparation except improving cleaning and polishing effect, prevents that also preparation from the migration and the destabilization of composition taking place in being matched with selected scope effectively the time in storage life.Therefore multiphase toothpaste of the present invention not only can increase the aesthetic values of this class multiphase toothpaste, and obtains desired cleaning and polishing effect under the situation of the desired preparation stability that does not damage this class multiphase toothpaste.
Claims (9)
1. one kind comprises opaque phase and clear gel multiphase toothpaste mutually, each is described to have the cleaning agent of effective dose or buffing compound mutually and is suspended in wherein mobile phase, wherein when a certain component content in the mobile phase more than 2% the time, have the described composition of respective amount in another mobile phase so that any substantial composition does not take place between mobile phase shift.
2. the multiphase toothpaste of claim 1, wherein content is no more than 35% more than 2% the difference of mobile phase composition between different opaque phase/gel phases in the described mobile phase of the described opaque phase/gel phase of each of heterogeneous combination.
3. claim 1 or 2 multiphase toothpaste, wherein mobile phase accounts for their 20 to 95% weight of place phase separately.
4. claim 1 or 2 multiphase toothpaste, wherein mobile phase accounts for their 30 to 90% weight of place phase separately.
5. each multiphase toothpaste in the claim 1 to 4, wherein opaque 4 to 70% the abrasive material that accounts for its weight that comprises mutually, gel phase comprise 4 to 40% the abrasive material that accounts for its weight.
6. each multiphase toothpaste in the claim 1 to 5, wherein opaque phase and gel phase also comprise 1 to 90% the wetting agent that accounts for separately weight mutually and 0.1 to 25% binding agent in addition.
7. one kind comprises two clear gels phases and opaque multiphase toothpaste mutually side by side, described clear gel accounts for 40 to 60% volumes of toothpaste volume mutually, described opaque 40 to 60% volumes that account for the toothpaste volume mutually, wherein each describedly has the cleaning agent/buffing compound of effective dose mutually and comprises mobile phase, selects to make the difference of main mobile phase composition between opaque phase/gel phase of described mobile phase of each described opaque phase/gel phase of heterogeneous combination to be not more than 50%.
8. the multiphase toothpaste of claim 7, wherein said clear gel accounts for 44 to 50% volumes of toothpaste volume mutually, described opaque 50 to 56% volumes that account for the toothpaste volume mutually.
9. each multiphase toothpaste during aforesaid right requires, described multiphase toothpaste opaquely comprises a plurality of clear gel phases that are configured to striped in mutually single.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN490MU2003 | 2003-05-19 | ||
| IN490/MUM/03 | 2003-05-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1791375A true CN1791375A (en) | 2006-06-21 |
| CN100566694C CN100566694C (en) | 2009-12-09 |
Family
ID=33446385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004800132908A Expired - Fee Related CN100566694C (en) | 2003-05-19 | 2004-04-15 | Multiphase toothpaste composition |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1641536A1 (en) |
| CN (1) | CN100566694C (en) |
| HK (1) | HK1091747A1 (en) |
| RU (1) | RU2345755C2 (en) |
| WO (1) | WO2004100913A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109069396A (en) * | 2016-06-29 | 2018-12-21 | 狮王株式会社 | Polychrome toothpaste preparation |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8894977B2 (en) | 2004-12-16 | 2014-11-25 | Colgate-Palmolive Company | Oral treatment compositions containing an anti-adhesion agent, antibacterial agent and incompatible compound |
| CN101115506B (en) * | 2004-12-16 | 2012-05-16 | 高露洁-棕榄公司 | Oral treatment compositions containing an anti-adhesion agent, antibacterial agent and incompatible compound |
| US9023323B2 (en) | 2004-12-16 | 2015-05-05 | Colgate-Palmolive Company | Oral compositions for prevention and reduction of bacterial adhesion to oral surfaces |
| WO2006081934A1 (en) * | 2005-02-04 | 2006-08-10 | Unilever N.V. | Multiphase toothpaste composition |
| WO2006125598A1 (en) * | 2005-05-27 | 2006-11-30 | Unilever Plc | Improved cosmetic composition |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1397248A (en) * | 1971-10-20 | 1975-06-11 | Beecham Inc | Dental compositions |
| DE3114492A1 (en) * | 1981-04-10 | 1982-10-28 | Degussa Ag, 6000 Frankfurt | DENTAL CARE |
| US4456585A (en) * | 1983-05-16 | 1984-06-26 | Colgate-Palmolive Company | Visually clear pigment-colored dentifrice composition |
| AU578392B2 (en) * | 1984-07-31 | 1988-10-20 | Lion Corporation | Toothpaste composition containing silica |
| US4943429A (en) * | 1988-05-23 | 1990-07-24 | Church & Dwight Co., Inc. | Dentifrice gels containing sodium bicarbonate |
| KR0128494B1 (en) * | 1994-07-26 | 1998-04-04 | 최무섭 | Heab medicine extract-containing non-bleeding striped dentifrice composition |
| BR9800802B1 (en) * | 1998-02-05 | 2009-01-13 | composition and oral care product. | |
| US6479036B1 (en) * | 1998-06-05 | 2002-11-12 | Crosfield Limited | Particulate materials for use in dentifrice compositions |
| DE19845247A1 (en) * | 1998-10-01 | 2000-04-06 | Henkel Kgaa | Liquid tooth cleaning gel |
| DE10017998A1 (en) * | 2000-04-11 | 2001-10-18 | Henkel Kgaa | Anti-plaque liquid tooth cleaning gel |
-
2004
- 2004-04-15 EP EP04727561A patent/EP1641536A1/en not_active Withdrawn
- 2004-04-15 CN CNB2004800132908A patent/CN100566694C/en not_active Expired - Fee Related
- 2004-04-15 WO PCT/EP2004/004006 patent/WO2004100913A1/en active Application Filing
- 2004-04-15 RU RU2005139561/15A patent/RU2345755C2/en not_active IP Right Cessation
-
2006
- 2006-11-10 HK HK06112437.0A patent/HK1091747A1/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109069396A (en) * | 2016-06-29 | 2018-12-21 | 狮王株式会社 | Polychrome toothpaste preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004100913A1 (en) | 2004-11-25 |
| RU2345755C2 (en) | 2009-02-10 |
| EP1641536A1 (en) | 2006-04-05 |
| CN100566694C (en) | 2009-12-09 |
| HK1091747A1 (en) | 2007-01-26 |
| RU2005139561A (en) | 2006-05-10 |
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