KR970004036B1 - Dentifrice compositions - Google Patents

Abstract

The liquid toothpaste composition consists of 5~50wt% of silica only being the function of toothpaste composition, 0.1~30wt% of xanthangum as binder, 10~80wt% of the mixed or individual polyvalent alcohol such as sorbitol liquid(70%), polyethylene glycol, propylene glycol or etc. as dampness agent, also 0.1~5wt% of alkyl polyglycosides as nonionic surfactant beings used as the foaming agent among toothpaste composition.

Description

Liquid Toothpaste Composition

The present invention relates to a dentifrice composition of the liquid type, and more particularly, to a dentifrice composition having good dispersibility in use and good fluidity at low and high temperatures with time, and no delamination.

Japanese Patent Application Laid-Open No. 92-217615 describes a liquid type toothpaste, but does not completely improve fluidity at low and high temperatures over time, and uses polyglycerine fatty acid esters to stimulate irritation of the oral mucosa. It seems to have tried to minimize.

In addition, Japanese Patent Application Laid-Open No. 92-210908 describes a liquid-type toothpaste characterized by using a combination of xanthan gum and polyacrylate as a binder, but it is unclear to improve the fluidity at low and high temperatures over time. The product's stability over time (layer separation) is considered poor.

To explain why the fluidity of the product is important at low and high temperatures over time, such low-viscosity liquid toothpaste is difficult to pack in a tube, which is a common toothpaste packaging bar. It is common to use plastic bottles. However, if the product does not flow out of the container at low or high temperatures over time (Gelification), it must be worthless as a product.

In order to improve this point, the inventors of the present invention conducted a long-term trial evaluation in various fields, and found that the type of abrasive and its average particle size and specific surface area should have an appropriate value. The use of alkyl polyglucoside, which is a nonionic surfactant, has been found to improve fluidity and stability at low and high temperatures over time, thereby completing the present invention.

Hereinafter, the present invention will be described in more detail.

Toothpaste compositions generally comprise abrasives, binders, wetting agents, foaming agents, sweetening agents, preservatives, agonists and flavors.

First, in a conventional toothpaste composition, calcium hydrogen dihydrogen phosphate, hydrous silica, calcium carbonate, polyaluminum, etc. are used as abrasives, but in the toothpaste composition of the present invention, 5 to 50% by weight of hydrous silica alone is preferred. 30 wt% is used, and the water-containing silica used herein has an average particle diameter of 1 to 15 microns and a specific surface area of 200 cm ² / g or less.

As the binder, carboxymethylcellulose sodium, carrageenan, xanthan gum, polyacrylate, sodium alginate and the like are generally used, but in the present invention, xanthan gum alone is used in an amount of 0.1 to 3% by weight, preferably 0.1 to 1.5% by weight.

In the conventional ointment toothpaste, the binding agent stably binds the solid abrasive to the liquid humectant in water and prevents the separation from occurring.However, in the low viscosity liquid toothpaste, the separation between the solid and the liquid component is of course suppressed. It is an important ingredient influencing the fluidity of the product over time.

The humectant has a function of preventing the toothpaste from solidifying when exposed to air, and mainly 10 to 80% by weight of polyhydric alcohols such as sorbitol solution (70%), glycerin, polyethylene glycol, and propylene glycol alone or mixed. 20 to 70% by weight is used.

When using toothpaste, it is necessary to use a foaming agent to create a foam and improve the feeling of use, and to increase the cleaning power. An alkyl surfactant, anionic surfactant, is mainly used. A nonionic surfactant such as polyoxyethylene polyoxypropylene is also used. have. Sodium alkyl sulfate showed slight irritation to the oral mucosa when used in excess and a juice effect after brushing, but it was generally found to be irritation when used below 3% by weight in toothpaste. In the present invention, the sodium alkyl sulfate alone is used at 2% by weight or less.

In addition, in the present invention, as the nonionic surfactant which can be used as the foaming agent in the toothpaste composition, the preferred amount of alkyl polyglucoside (Alkyl polyglycosides) is used for the purpose of improving fluidity over time is 0.1 to 5% by weight.

In addition, flavors and sweeteners are used to control the bitter or somewhat bitter taste caused by abrasives and foaming agents, and mainly flavors such as peppermint and spearmint oil are used, and 0.5 to 1.5% by weight of toothpaste is used.

As the sweetener, synthetic or natural non-fermentable sugars are mainly used, and representative examples thereof include saccharin sodium, aspartame, stevioside, acesulfame, ammonium, potassium salt, isomerized sugar, sorbitol of licorice or licorice, and the like. Preferably, 0.01 to 0.5% by weight of saccharin sodium, aspartame, ammonium and potassium salts of licorice are used alone or in combination.

Preservatives are used to prevent microbial contamination that may occur during manufacture and use of toothpaste compositions, and paraoxybenzoate, benzoic acid, sodium benzoate, salicylic acid, etc. Preferably, 0.01 to 0.5% by weight of methyl paraoxybenzoate, propyl paraoxybenzoate, benzoic acid and sodium benzoate alone or in combination is used.

In addition, according to the purpose of use, the dentifrice composition can be used a suitable medicament. Drugs include cavities prevention and periodontal disease prevention, and as a cavities prevention agent is typically used a fluorine compound, for example, sodium fluoride, sodium monofluoride phosphate, amine fluoride and the like can be used.

In addition, small amounts of cationic surfactants such as chlorohexidine salt, benzalkonium chloride, benzenetonium chloride, and quaternary ammonium compounds are added for the purpose of sterilizing caries in the oral cavity, and enzymes can be used to suppress and remove plaque. have.

As a treatment for periodontal disease, it is a high osmotic effect that disinfects and disinfects. Sodium chloride, an anti-plasmin agent that suppresses edema and bleeding. Batamines and the like can be used.

Liquid toothpaste composition according to the present invention is characterized in that the viscosity of the final product is 1,000 to 10,000CPS at 25 ℃, compared to the conventional ointment toothpaste is good in dispersibility when used and the same brushing time lengthening the contact time and fragrance Increased divergence and low viscosity of the product is expected to reduce power costs during manufacturing.

EMBODIMENT OF THE INVENTION Hereinafter, this invention is demonstrated concretely based on an Example.

Example

The liquid component was measured and dispersed therein with stirring at about 3,000 rpm, followed by dispersion of the minor components (preservatives, medicaments, etc.) again, and the addition of an abrasive, followed by mixing at 2,500 rpm for 20 minutes. The foaming agent and the fragrance were added here, and it stirred for 30 minutes in vacuum, maintaining 2,000 to 3,000 rpm.

Toothpaste compositions of Examples 1 to 5 and the toothpaste compositions of Comparative Examples 1 to 4 were prepared according to the above methods with the compositions shown in Table 1 below.

TABLE 1

(Unit: weight%)

The dispersibility, time-liquidity and time-lapse stability of the dentifrice compositions of the Examples and Comparative Examples were evaluated as follows.

(1) dispersibility test

Apply exactly 30 g of the composition of the Examples and Comparative Examples to a beer dryer having the same bottom surface area, clean and dried, and gently take 70 g of tap water along the wall of the beer, add a stirrer to the tap water layer and stir at 100 rpm for 30 seconds. The dispersibility of the toothpaste composition was evaluated by tilting the beaker to discard the upper water layer and measuring the amount of toothpaste remaining without being dispersed in water.

As shown in the table, the remaining amounts of the compositions of the examples were not dispersed, and the compositions of the examples were found to be superior to the compositions of the comparative examples. As a result of evaluating 50 compositions and evaluating the two compositions, 38 evaluators said that the composition of Example 1 had excellent dispersibility when brushing, and that the composition of Comparative Example 1 had excellent dispersibility when brushing. 4 people, similar or not sure about 8 people appeared that the composition of the Example was excellent dispersibility even when the actual brushing.

(2) Liquidity test over time (Sensory evaluation)

In order to evaluate the flowability of the contents according to the storage conditions and the time of storage for the compositions of Examples and Comparative Examples, each composition was filled with about 150 g of a composition in a 200 ml transparent plastic container, followed by Fluidity was evaluated for the compositions at 1 and 3 months with storage for 3 months).

※ Evaluation standard

1. When the container is tilted 90 °, there is no change at all (Gelization).

2. Flows very slowly when the container is tilted 90 °.

3. Slowly flow when the container is tilted 90 °.

4. Flows well when the container is tilted 90 °.

5. The container flows very well when tilted at 90 °.

o Evaluation result comparison table

As shown in the above table, the liquid dentifrice composition of Example was evaluated to have better fluidity at low temperature, room temperature, and high temperature over time than the toothpaste composition of Comparative Example.

(3) Liquidity test over time (yield point measurement)

Evaluation of the fluidity was evaluated by comparing the composition of the Example and Comparative Example by measuring the yield point (Yeid Point) using the rheometer. Yield point is, in a rheological sense, the maximum stress that a fluid has at its zero shear rate, i.e. when it is slowly applied to a stationary fluid, the fluid moves. It can be seen as a starting point. Therefore, the lower the yield point, the better the fluidity, and the yield point for the compositions of Examples and Comparative Examples over time at low and high temperatures were compared and evaluated using rheometer (HAAKE).

Evaluation result comparison table (yield point, unit N / m ² )

As can be seen from the above results, the yield point value with time is measured to be smaller than the composition of the comparative example, it can be seen that the fluidity over time is excellent.

(4) stability test over time

After the test specimens were prepared in the same manner as in the fluidity test over time, 1 month, 3 months of storage for 6 months at low temperature (-10 ° C), room temperature 40 ° C, 50 ° C and circulation (temperature change from -5 ° C to 40 ° C) The stability over time for the composition at months and 6 months was evaluated.

※ Evaluation standard

◎ Very good (same as initial state)

○ Good (contents state is good)

□ Relatively good (Liquid separation is very slight)

△ relatively poor (showing the surface liquid separation phenomenon)

× Poor (total liquid separation phenomenon)

* Very poor (complete delamination)

Evaluation result comparison table

As shown in the above table, the results of the stability of the liquid toothpaste compositions of the Examples and Comparative Examples with similar results (slightly better) at low temperature and room temperature, but the Example was evaluated as excellent at high temperature (40 ° C, 50 ° C) and circulation.

Claims (6)

A liquid therapeutic composition comprising hydrous silica, xanthan gum and alkylpolyglucosides. The liquid toothpaste composition according to claim 1, wherein the average particle diameter of the hydrous silica is 1 to 15 microns and the specific surface area is 200 cm ² / g or less. The liquid dentifrice composition of claim 1 wherein the final product has a viscosity of from 1,000 to 10,000 cpc at 25 ° C. 3. The liquid toothpaste composition according to claim 1, wherein the amount of the alkylpolyglucoside is 0.1 to 5% by weight. The liquid toothpaste composition according to claim 1, wherein the amount of xanthan gum used is 0.1 to 3% by weight. The liquid toothpaste composition according to claim 2, wherein the amount of water-containing silica is 10 to 30% by weight.