CN1788720A - 赛米司酮类用于治疗抑郁症的用途 - Google Patents
赛米司酮类用于治疗抑郁症的用途 Download PDFInfo
- Publication number
- CN1788720A CN1788720A CNA2004100930365A CN200410093036A CN1788720A CN 1788720 A CN1788720 A CN 1788720A CN A2004100930365 A CNA2004100930365 A CN A2004100930365A CN 200410093036 A CN200410093036 A CN 200410093036A CN 1788720 A CN1788720 A CN 1788720A
- Authority
- CN
- China
- Prior art keywords
- depression
- symipristone
- mifepristone
- dexamethasone
- glucocorticoid receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Description
受试化合物浓度(mol/L) | 地塞米松 | 赛米司酮 | 米非司酮 |
5×10-7 | 89.23±8.56 | 95.36±5.34 | 93.84±3.78 |
1×10-7 | 60.37±5.67 | 88.94±9.01 | 88.95±5.69 |
2×10-8 | 39.42±4.83 | 75.60±3.56 | 70.24±4.13 |
4×10-9 | 24.83±5.92 | 54.54±4.24 | 46.84±7.25 |
8×10-10 | 14.72±7.34 | 31.25±3.87 | 24.43±3.97 |
16×10-10 | 10.37±6.11 | 17.25±6.76 | 16.74±8.07 |
受试化合物 | IC50(nmol/L) | RBA(%) |
地塞米松赛米司酮米非司酮 | 14.50±1.892.60±0.534.21±1.02 | 100.00557.69±65.23344.41±57.41 |
浓度(mol/L) | 赛米司酮 | 米非司酮 |
6×10-82×10-76×10-72×10-6 | 80.0±4.367.2±2.976.0±3.863.6±5.1 | 83.0±5.275.9±3.777.3±4.173.6±6.3 |
浓度(mol/L) | 赛米司酮 | 米非司酮 |
6×10-82×10-76×10-72×10-6 | 35.2±2.457.7±3.542.2±1.964.1±5.6 | 29.9±2.642.4±5.739.9±4.246.5±3.4 |
Claims (5)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200410093036A CN100588393C (zh) | 2004-12-15 | 2004-12-15 | 赛米司酮类用于治疗抑郁症的用途 |
PCT/CN2005/002194 WO2006063526A1 (fr) | 2004-12-15 | 2005-12-15 | Utilisation de la cymipristone pour le traitement de la depression |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200410093036A CN100588393C (zh) | 2004-12-15 | 2004-12-15 | 赛米司酮类用于治疗抑郁症的用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1788720A true CN1788720A (zh) | 2006-06-21 |
CN100588393C CN100588393C (zh) | 2010-02-10 |
Family
ID=36587541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200410093036A Active CN100588393C (zh) | 2004-12-15 | 2004-12-15 | 赛米司酮类用于治疗抑郁症的用途 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN100588393C (zh) |
WO (1) | WO2006063526A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102106805B (zh) * | 2009-12-29 | 2013-06-12 | 上海中西制药有限公司 | 赛米司酮固体制剂及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1023074B1 (en) * | 1997-10-06 | 2006-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating psychosis associated with glucocorticoid related dysfunction |
CN1117759C (zh) * | 1999-09-02 | 2003-08-13 | 上海中西药业股份有限公司 | 甾体化合物,其制备方法和其药物组合物及其应用 |
-
2004
- 2004-12-15 CN CN200410093036A patent/CN100588393C/zh active Active
-
2005
- 2005-12-15 WO PCT/CN2005/002194 patent/WO2006063526A1/zh not_active Application Discontinuation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102106805B (zh) * | 2009-12-29 | 2013-06-12 | 上海中西制药有限公司 | 赛米司酮固体制剂及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN100588393C (zh) | 2010-02-10 |
WO2006063526A1 (fr) | 2006-06-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C57 | Notification of unclear or unknown address | ||
DD01 | Delivery of document by public notice |
Addressee: Zuo Lin Document name: Notification before expiration of term |
|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee | ||
CP02 | Change in the address of a patent holder |
Address after: 201203 Shanghai city Pudong New Area Cailun Road No. 333 building D room 505 Patentee after: Shanghai Sanhe Biotech Co., Ltd. Address before: 201203, room 1043, 304 Harley Road, Zhangjiang hi tech park, Shanghai, Pudong New Area Patentee before: Shanghai Sanhe Biotech Co., Ltd. |
|
ASS | Succession or assignment of patent right |
Owner name: SHANGHAI ZHONGXI SUNVE PHARMACEUTICAL CO., LTD. SH Effective date: 20110829 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20110829 Address after: 201203 Shanghai city Pudong New Area Cailun Road No. 333 building D room 505 Co-patentee after: Shanghai Zhongxi Sunve Pharmaceutical Co., Ltd. Patentee after: Shanghai Sanhe Biotech Co., Ltd. Co-patentee after: Zhejiang Xianju Pharmaceutical Co., Ltd. Co-patentee after: Shanghai Zhongxi Pharmaceutical Co Ltd Address before: 201203 Shanghai city Pudong New Area Cailun Road No. 333 building D room 505 Patentee before: Shanghai Sanhe Biotech Co., Ltd. |