CN1785367A - Medicine for trenting flooding and spotting, haematemesis and homafecia - Google Patents
Medicine for trenting flooding and spotting, haematemesis and homafecia Download PDFInfo
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- CN1785367A CN1785367A CNA2005100963626A CN200510096362A CN1785367A CN 1785367 A CN1785367 A CN 1785367A CN A2005100963626 A CNA2005100963626 A CN A2005100963626A CN 200510096362 A CN200510096362 A CN 200510096362A CN 1785367 A CN1785367 A CN 1785367A
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Abstract
A Chinese medicine in the form of capsule, tablet, powder, dripping pill, or aerosol for treating uterine bleeding, hematemesis and hematochezia is prepared from 11 Chinese-medicinal materials including rhubarb, coptis root, notoginseng, donkey-hide gelatin, etc.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of metrorrhagia, hematemesis and having blood in stool.
Background technology
Metrorrhagia, hematemesis and to have blood in stool be commonly encountered diseases, frequently-occurring disease and difficult disease in the traditional Chinese medical science blood disorder have data to show that hematemesis, the sickness rate of having blood in stool are more than 12%, to be mainly in male adults, and the male is more than the women.External report metrorrhagia sickness rate is 22%, can betide menarche to any age between the menopause, and is in the majority with the adolescence sickness rate, accounts for 80%-90%, serious threat women physical and mental health.When hematemesis, the gastric and duodenal ulcers that is equivalent to western medicine of having blood in stool, acute or chronic gastritis, prolapse of gastric mucosa, gastric cancer, hepatitis interstitialis chronica at the bottom of the stomach and esophageal varicosis is broken, hemorrhage due to cholelithiasis, intestinal infection etc.Also be found in hematopathy, as thrombocytopenic purpura, aplastic anemia, leukemia and disseminated inravascular coagulation etc.In addition, late stage of uremia, during serious cranium disease of brain stress ulcer, also can cause hematemesis or have blood in stool.But clinically should merge the bleeder with gastric and duodenal ulcers and see more.This disease very easily causes complication such as gastric perforation, pyloric obstruction, even canceration takes place, patient's physical and mental health is had very big hazardness, as if untimely healing, delays with the passing of time, even constitute life danger.Doctor trained in Western medicine mainly adopts anti symptom treatment, prevents hemorrhage, replenishment of blood content, the secretion of cooperation gastric acid inhibitory, anticholinergic agent and H
2Receptor blocking agent etc.When medicine is invalid, then need surgical operation therapy.Metrorrhagia is equivalent to the dysfunctional uterine bleeding of modern medicine.Traditional Therapeutic Method has hormonotherapy, operative therapy, local treatment etc., the method for wherein stopping blooding mainly comprise dilatation and curettage, progestogen inner membrance peeling process, estrogen with film growth method, synthetic progestin inner membrance atrophy method, simple endometrectomy, burn the intrauterine embrane method, add heat damage endometrium method and hysterectomy method or the like merely.According to bibliographical information, hormone therapy needs to determine scheme according to patient's concrete condition, its advantage is to perform a surgical operation, and can keep fertility, but the course of treatment is long, method is loaded down with trivial details, and patient is difficult for adhering to, and side effect is many, as gastrointestinal upset, dizzy, celostomia, weight increase etc., thereby usually treat undesirable.The present invention selected topic just in fully investigation, analyze on the above-mentioned clinical status basis, propose according to social need, have great social meaning and tremendous economic meaning.
Summary of the invention
The purpose of this invention is to provide a kind of middle one-tenth thing for the treatment of metrorrhagia, hematemesis and having blood in stool, this medicine side effect is little, cure rate is high.
Solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to blood disorder, with reference to the modern pharmacological research achievement, by traditional Chinese medical science prescription theory, skims the cream off milk, and makes its performance clearing away heat and cooling blood, the effect of removing stasis to stop bleeding.
The objective of the invention is to realize that by following technical proposals a kind of medicine for the treatment of metrorrhagia, hematemesis and having blood in stool is characterized in that comprising following raw medicaments in portion by weight:
40～60 parts of 40～60 portions of Radix Notoginseng of 50～70 portions of Rhizoma Coptidis of Radix Et Rhizoma Rhei
30～55 parts of 40～60 parts of Os Draconis (calcined)s of 20～40 parts of Colla Corii Asini of the Radix Angelicae Dahuricae
30～55 parts of 20～40 portions of Endoconcha Sepiaes of 30～55 parts of Myrrha (processed)s of Pseudobulbus Bletillae (Rhizoma Bletillae)
10～20 parts of 40～60 parts of Sanguis Draxonis of Radix Rubiae.
In the above-mentioned raw materials medicine, also can add 1～10 part of 5～20 parts in Radix Glycyrrhizae and/or 1～10 part of Margarita and/or Borneolum Syntheticum.
Optimum weight part proportioning of the present invention is 65 parts of Radix Et Rhizoma Rhei, 50 parts of Rhizoma Coptidis, 50 parts of Radix Notoginseng, 31 parts of the Radixs Angelicae Dahuricae, 50 parts in Colla Corii Asini, 44 parts of Os Draconis (calcined)s, 44 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 31 parts of Myrrha (processed)s, 44 parts of Endoconcha Sepiaes, 50 parts in Radix Rubiae, 12 parts of Sanguis Draxonis.
In the above-mentioned raw materials medicine, also can add 4 parts of 11 parts in Radix Glycyrrhizae and/or 4 parts of Margaritas and/or Borneolum Syntheticums.
The present invention is technology and can be refined into capsule, tablet, powder, drop pill, aerosol by each dosage form requirement routinely.
Os Draconis (calcined) wherein: get clean Os Draconis (calcined) fritter, put in the refractory container, heating is with high heat forged to being popular in, and takes out airing, pulverizes.(seeing " science of Chinese drug processing " the 116th page)
Myrrha (processed) wherein: get clean Myrrha (processed) size separately, put in the pot with the slow fire heating, fry to smoldering, when the surface was glossy gloss, taking-up cooled.(seeing " science of Chinese drug processing " the 654th page)
Annotate: Ye Ding opens in the river hereditary servant chief editor. the science of Chinese drug processing. and the 1st edition. Beijing: People's Health Publisher, 2002.
Technical scheme of the present invention is treatment metrorrhagia, hematemesis and have blood in stool and develop, Radix Et Rhizoma Rhei, Rhizoma Coptidis in the present invention's prescription, and the clearing away heat and cooling blood hemostasis, blood stasis-eliminating and stagnation-dissipating is capable stagnates, and is monarch drug altogether; The Radix Et Rhizoma Rhei bitter cold is returned spleen, stomach, large intestine channel, gets the property of its bitter cold sedimentation, lets out with preventing or arresting vomiting blood below making inflammation fiery; The energy of desirable again its blood circulation promoting and blood stasis dispelling, the blood stasis place is long-pending to control, fresh blood is not given birth to, hemorrhage all cards of escape of blood from meridian.As ancients' cloud: " Radix Et Rhizoma Rhei can be gone into blood system, removing blood stasis with potent drugs blood, and it is descending to draw gastric qi, so kind preventing or arresting vomiting blood ".And also nature and flavor bitter cold of Rhizoma Coptidis, GUIXIN, stomach, large intestine channel, the special eliminating fire and detoxication of merit, pathogenic fire purging remove steams, skin ulcer is treated in the hot-tempered wet detoxifcation of heat clearing away, its negative conversion rate that suppresses helicobacter pylori is 80%, both can be used for the haematemesis due to intenseness of heat heated, the absurd row of forcing blood, can be used for all cards of having blood in stool, suffer from abdominal pain due to the intestines and stomach damp-heat accumulation again, be harmonious and usefulness with Radix Et Rhizoma Rhei, be the master in the side altogether.And Radix Notoginseng, Sanguis Draxonis, Radix Rubiae, Myrrha (processed), Colla Corii Asini, Radix Angelicae Dahuricae Six-element are we's ministerial drug, and this is " system of monarch's two ministers six also ".Wherein the little hardship of Radix Notoginseng is gone into the stomach warp, removing stasis to stop bleeding, and the characteristic of stopping blooding and not staying the stasis of blood is arranged, and Radix Notoginseng includes arasaponin, flavonoid glycoside, alkaloid, has the dissipating blood stasis hemostasis, and subduing swelling and relieving pain reduces capillary permeability, improves vascular fragility, repairs the effect of mucosal ulcer; Sanguis Draxonis is sweet salty, and the salty in the mouth person specially goes into blood system, but promoting blood circulation to remove blood stasis pain relieving for oral administration also has the magical effect of stopping blooding and not staying the stasis of blood; The Radix Rubiae bitter cold, cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling; The Myrrha (processed) promoting blood circulation and stopping pain, detumescence and promoting granulation, and the relatively length of " blood looses " is arranged; And Colla Corii Asini is sweet flat, and the nourishing YIN and supplementing blood hemostasis is the key medicine of hemostasis, with the same usefulness of Rhizoma Coptidis, kind stopping vomiting blood, have blood in stool, and that the Radix Angelicae Dahuricae dispels the wind is hot-tempered wet, and detumescence and apocenosis, pain relieving, the person that bursts can loose in energy dissipating, person's energy evacuation of pus pain relieving of bursting.Six mutually 5, or blood circulation promoting and dispersing pathogen accumulation, blood-activating analgetic, or the YIN nourishing of enriching blood, turn round and look at and originally just protect, or dampness evacuation of pus, subduing swelling and relieving pain, the effect of the clearing away heat and cooling blood of principal drug assistance hemostasis altogether, eliminating stasis and resolving masses analgesic therapy.And Os Draconis (calcined), Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Margarita, the genus of Borneolum Syntheticum, be the adjuvant drug in the side, the Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation, its contained Rhizoma Bletillae gel can make on the mucosa of liking to decrease and form thin film, promotes the growth of wound surface granulation tissue and increase wound surface to ooze out polymorphonuclear leukocyte, mononuclear cell and fibroblast, helps hemostasis, reparation and infection; The Os Draconis (calcined) convergence is astringent or styptic treatment for spontaneous sweating, skin ulcer is held back in moisture absorption; The Endoconcha Sepiae astringing to arrest bleeding is equal to usefulness with the Radix Angelicae Dahuricae, Borneolum Syntheticum, can control the many pus of ulcer; Margarita, Borneolum Syntheticum clearing away heat to alleviate pain are controlled ulcer not closing in for a long time person and are imitated Zhuo.Five medicines are harmonious, and assistant helps the monarch and his subjects to strengthen the effect of hemostasis first, doublely first control haematemesis, have blood in stool and accompany ulcer pain.As for the messenger drug in the Radix Glycyrrhizae side of being, Radix Glycyrrhizae is sweet flat, goes into the taste warp, relieving spasm to stop pain arranged, relax the property of medicine, priming return through merit, Radix Glycyrrhizae and Radix Et Rhizoma Rhei match, and can relax its discharge function again.As " medication on the analogy of natural things " cloud: " Radix Glycyrrhizae ... its performance emergency and all medicines of coordinating makes it out of question, so slow its heat that the medicine of a warm nature gets, cold medicine gets, and slow it is cold.”
In a word, our monarch matches, the product of the thing of clearing away heat and cooling blood hemostasis and blood-activating analgetic convergence mutually 5, and Each performs its own functions, complements each other again.Full side pays attention to hemostasis and does not stay the stasis of blood, blood stasis dispelling and motionless blood, but to receive both clearing away heat and cooling blood hemostasis, but the merit of blood stasis dispelling promoting granulation and relieving pain again in order to the hematemesis due to the treatment heat in blood blood stasis, have blood in stool, can make that its pyretic toxicity is clear, blood stasisization, QI and blood transfer, its the pain must, its hemorrhage must ending.
Dosage form of the present invention has capsule, tablet, powder, drop pill, aerosol.
Be that situation is summed up in product treatment metrorrhagia, the hematemesis of the present invention and the clinical trial of having blood in stool below.
Product of the present invention is born clinical trial by The People's Hospital, adopts Chinese medicine preparation to treat hemorrhage 208 examples of the different causes of disease, and establishes YUNNAN BAIYAO matched group 210 examples, and the result treated 7 days, product total effective rate 95.7% of the present invention.Point out product of the present invention to have rapid hemostasis and the obviously effect of promotion wound healing.Now clinical trial data is summarized as follows:
In physical data 418 examples, male 217 examples, women 201 examples; Mean age 48.3 ± 4.3.Chinese medical discrimination belongs to capable 99 examples of hot forcing blood, hyperactivity of fire caused by deficiency of YIN 62 examples, deficient QI failing to control 47 examples.Metrorrhagia 85 examples wherein, digestive tract hemorrhage and hematemesis 65 examples, 58 examples of having blood in stool.Selected patient amount of bleeding＜500ml every day.Because of patient hemorrhage due to the hematopathy not at the row of observation.
Therapeutic Method is divided into treatment group and YUNNAN BAIYAO matched group at random with 418 routine patients.Drug specifications of the present invention is the 0.3g/ grain, every day 3 times, each 4, takes continuously 7 days.Detect routine blood test respectively before and after the treatment, go out, clotting time, prothrombin time, excrement occult blood, routine urinalysis, liver, renal function.
Criterion of therapeutical effect is that baseline is evaluated with amount of bleeding before treating.The haemostatic effect standards of grading are: fully recovering stops for treating the back amount of bleeding; Produce effects is for reducing more than 〉=60%; Progressive for reducing 30%～60%; Invalid for reducing≤30%.Add up to effectively with recovery from illness and produce effects, and calculate effective percentage.
Therapeutic outcome 1. medicines of the present invention are treated hemorrhage clinical efficacy of the 208 routine different causes of disease and the hemorrhage clinical efficacy of different pattern of syndrome, see Table 1, table 2.
Table 1. medicine of the present invention is treated the hemorrhage clinical efficacy of the 208 routine different causes of disease
| Disease | n | Recovery from illness | Produce effects | Progressive | Invalid | Total effective rate (%) |
| Metrorrhagia digestive tract hemorrhage and hematemesis are had blood in stool | 85 65 58 | 63 58 39 | 13 9 11 | 4 4 3 | 5 4 5 | 94.1 93.8 91.4 |
Table 2. medicine of the present invention is treated the hemorrhage clinical efficacy of 208 routine different pattern of syndrome
| Differentiation of symptoms and signs for classification of syndrome | n | Recovery from illness | Produce effects | Progressive | Invalid | Total effective rate (%) |
| The capable hyperactivity of fire caused by deficiency of YIN deficient QI failing to control of hot forcing blood | 99 62 47 | 92 40 28 | 7 19 8 | 0 1 4 | 0 2 7 | 100.0 95.2 76.6 |
As can be seen from Table 1, medicine of the present invention is preferable to metrorrhagia in the treatment group, digestive tract hemorrhage and hematemesis, the effect of having blood in stool.
As can be seen from Table 2, medicine of the present invention can all be cured hot forcing blood passerby curative effect the best in the treatment group, and hyperactivity of fire caused by deficiency of YIN and deficient QI failing to control person take second place.
2. two groups of treatment back curative effects relatively: effective percentage no significant difference after treatment group and the treatment of control group (P＞0.05).But treatment group recovery from illness example several 160 examples (76.9%) obviously increase than matched group 113 examples (53.8%)) (P＜0.05).Two groups of curative effects relatively see Table 3.
The curative effect of table 3. medicine of the present invention and YUNNAN BAIYAO relatively
| Differentiation of symptoms and signs for classification of syndrome | n | Recovery from illness | Produce effects | Progressive | Invalid | Total effective rate (%) |
| Treatment group matched group | 208 210 | 160 113 | 34 80 | 5 7 | 9 10 | 95.7 95.2 |
Specific embodiment
The invention is further illustrated by the following examples, and the present invention is not limited only to described embodiment.
Embodiment 1
By following weight weighting raw materials (unit: gram)
Radix Et Rhizoma Rhei 65, Rhizoma Coptidis 50, Radix Notoginseng 50, the Radix Angelicae Dahuricae 31, Colla Corii Asini 50, Os Draconis (calcined) 44, Pseudobulbus Bletillae (Rhizoma Bletillae) 44, Myrrha (processed) 31, Endoconcha Sepiae 44, Radix Rubiae 50, Sanguis Draxonis 12.
Preparation method: above medical material, get Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, add 3～8 times of amounts of 80% ethanol, the reflux secondary, each 1～3 hour, merge alcohol extract, filter, reclaim ethanol, clear paste is standby; Medicinal residues and Radix Rubiae add 8～12 times of amounts of water, decoct secondary, and each 1～3 hour, collecting decoction filtered, and mixes with above-mentioned alcohol extract, and it is the thick paste of 1.35～1.38 (60 ℃ of mensuration) that concentrating under reduced pressure becomes relative density, and drying is ground into fine powder, and is standby; Get Radix Notoginseng, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae) and mix pulverizing 60 ℃ of dry backs with Os Draconis (calcined), Myrrha (processed), Colla Corii Asini, fine powder is standby; Sanguis Draxonis is made fine powder, with above-mentioned two fine powder mix homogeneously, adds appropriate amount of starch, the system granule, and mixing promptly gets capsule.
Embodiment 2
By following weight weighting raw materials (unit: kilogram)
Radix Et Rhizoma Rhei 50, Rhizoma Coptidis 40, Radix Notoginseng 40, the Radix Angelicae Dahuricae 20, Colla Corii Asini 40, Os Draconis (calcined) 30, Pseudobulbus Bletillae (Rhizoma Bletillae) 30, Myrrha (processed) 20, Endoconcha Sepiae 30, Radix Rubiae 40, Sanguis Draxonis 10.
Preparation method: above medical material, get Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, add 3～8 times of amounts of 80% ethanol, the reflux secondary, each 1～3 hour, merge alcohol extract, filter, reclaim ethanol, clear paste is standby; Medicinal residues and Radix Rubiae add 8～12 times of amounts of water, decoct secondary, and each 1～3 hour, collecting decoction filtered, and mixes with above-mentioned alcohol extract, and it is the thick paste of 1.35～1.38 (60 ℃ of mensuration) that concentrating under reduced pressure becomes relative density, and drying is ground into fine powder, and is standby; Get Radix Notoginseng, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae) and mix pulverizing 60 ℃ of dry backs with Os Draconis (calcined), Myrrha (processed), Colla Corii Asini, fine powder is standby; Sanguis Draxonis is made fine powder, with above-mentioned two fine powder mix homogeneously, adds appropriate amount of starch, the system granule, and tabletting promptly gets tablet.
Embodiment 3
By following weight weighting raw materials (unit: kilogram)
Radix Et Rhizoma Rhei 70, Rhizoma Coptidis 60, Radix Notoginseng 60, the Radix Angelicae Dahuricae 40, Colla Corii Asini 60, Os Draconis (calcined) 55, Pseudobulbus Bletillae (Rhizoma Bletillae) 55, Myrrha (processed) 40, Endoconcha Sepiae 55, Radix Rubiae 60, Sanguis Draxonis 20, Margarita 10.
Preparation method: above medical material, get Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, add 3～8 times of amounts of 80% ethanol, the reflux secondary, each 1～3 hour, merge alcohol extract, filter, reclaim ethanol, clear paste is standby; Medicinal residues and Radix Rubiae add 8～12 times of amounts of water, decoct secondary, and each 1～3 hour, collecting decoction filtered, and mixes with above-mentioned alcohol extract, and it is the thick paste of 1.35～1.38 (60 ℃ of mensuration) that concentrating under reduced pressure becomes relative density, and drying is ground into fine powder, and is standby; Get Radix Notoginseng, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae) and mix pulverizing 60 ℃ of dry backs with Os Draconis (calcined), Myrrha (processed), Colla Corii Asini, fine powder is standby; Sanguis Draxonis and Margarita are made fine powder, with above-mentioned two fine powder mix homogeneously, cross 100 mesh sieves, promptly get powder.
Embodiment 4
By following weight weighting raw materials (unit: gram)
Radix Et Rhizoma Rhei 55, Rhizoma Coptidis 45, Radix Notoginseng 45, the Radix Angelicae Dahuricae 25, Colla Corii Asini 45, Os Draconis (calcined) 35, Pseudobulbus Bletillae (Rhizoma Bletillae) 35, Myrrha (processed) 25, Endoconcha Sepiae 35, Radix Rubiae 45, Sanguis Draxonis 15, Borneolum Syntheticum 3.
Preparation method: above medical material, get Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, add 3～8 times of amounts of 80% ethanol, the reflux secondary, each 1～3 hour, merge alcohol extract, filter, reclaim ethanol, clear paste is standby; Medicinal residues and Radix Rubiae add 8～12 times of amounts of water, decoct secondary, and each 1～3 hour, collecting decoction filtered, and mixes with above-mentioned alcohol extract, and it is the thick paste of 1.35～1.38 (60 ℃ of mensuration) that concentrating under reduced pressure becomes relative density, and drying is ground into fine powder, and is standby; Get Radix Notoginseng, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae) and mix pulverizing 60 ℃ of dry backs with Os Draconis (calcined), Myrrha (processed), Colla Corii Asini, fine powder is standby; Sanguis Draxonis is made fine powder, with above-mentioned two fine powder mix homogeneously, adds the Borneolum Syntheticum of making fine powder again, and mixing adds an amount of polyethylene glycol 6000 and magnesium stearate, makes drop pill.
Embodiment 5
By following weight weighting raw materials (unit: gram)
Radix Et Rhizoma Rhei 60, Rhizoma Coptidis 55, Radix Notoginseng 55, the Radix Angelicae Dahuricae 35, Colla Corii Asini 55, Os Draconis (calcined) 50, Pseudobulbus Bletillae (Rhizoma Bletillae) 50, Myrrha (processed) 36, Endoconcha Sepiae 50, Radix Rubiae 55, Sanguis Draxonis 18, Radix Glycyrrhizae 5.
Preparation method: above medical material, get Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, add 3～8 times of amounts of 80% ethanol, the reflux secondary, each 1～3 hour, merge alcohol extract, filter, reclaim ethanol, clear paste is standby; Medicinal residues and Radix Rubiae and Radix Glycyrrhizae add 8～12 times of amounts of water, decoct secondary, and each 1～3 hour, collecting decoction filtered, and mixes with above-mentioned alcohol extract, and it is the thick paste of 1.35～1.38 (60 ℃ of mensuration) that concentrating under reduced pressure becomes relative density, and drying is ground into fine powder, and is standby; Get Radix Notoginseng, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae) and mix pulverizing 60 ℃ of dry backs with Os Draconis (calcined), Myrrha (processed), Colla Corii Asini, fine powder is standby; Sanguis Draxonis is made fine powder, with above-mentioned two fine powder mix homogeneously, is ground into pasty state with an amount of Arlacel-85, crosses colloid mill with 12000rpm, gets particle diameter less than 10 μ m, puts in the container, adds valve, sealing cap, is pressed into propellant, shakes up, and gets powder aerosol.
Embodiment 6
By following weight weighting raw materials (unit: gram)
Radix Et Rhizoma Rhei 65, Rhizoma Coptidis 50, Radix Notoginseng 50, the Radix Angelicae Dahuricae 31, Colla Corii Asini 50, Os Draconis (calcined) 44, Pseudobulbus Bletillae (Rhizoma Bletillae) 44, Myrrha (processed) 31, Endoconcha Sepiae 44, Radix Rubiae 50, Sanguis Draxonis 12, Radix Glycyrrhizae 10, Borneolum Syntheticum 10.
Preparation method: above medical material, get Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, add 3～8 times of amounts of 80% ethanol, the reflux secondary, each 1～3 hour, merge alcohol extract, filter, reclaim ethanol, clear paste is standby; 8～12 times of amounts of medicinal residues and Radix Rubiae and Radix Glycyrrhizae mixing and water adding decoct secondary, and each 1～3 hour, collecting decoction filtered, and mixes with above-mentioned alcohol extract, and it is the thick paste of 1.35～1.38 (60 ℃ of mensuration) that concentrating under reduced pressure becomes relative density, and drying is ground into fine powder, and is standby; Get Radix Notoginseng, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae) and mix pulverizing 60 ℃ of dry backs with Os Draconis (calcined), Myrrha (processed), Colla Corii Asini, fine powder is standby; Sanguis Draxonis is ground into fine powder, with above-mentioned two fine powder mix homogeneously, adds appropriate amount of starch, and the system granule sprays into the Borneolum Syntheticum with anhydrous alcohol solution again, and mixing promptly gets capsule.
Embodiment 7
By following weight weighting raw materials (unit: gram)
Radix Et Rhizoma Rhei 52, Rhizoma Coptidis 44, Radix Notoginseng 44, the Radix Angelicae Dahuricae 24, Colla Corii Asini 44, Os Draconis (calcined) 35, Pseudobulbus Bletillae (Rhizoma Bletillae) 35, Myrrha (processed) 26, Endoconcha Sepiae 33, Radix Rubiae 44, Sanguis Draxonis 16, Margarita 1, Borneolum Syntheticum 1.
Preparation method: above medical material, get Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, add 3～8 times of amounts of 80% ethanol, the reflux secondary, each 1～3 hour, merge alcohol extract, filter, reclaim ethanol, clear paste is standby; 8～12 times of amounts of medicinal residues and Radix Rubiae mixing and water adding decoct secondary, and each 1～3 hour, collecting decoction filtered, and mixes with above-mentioned alcohol extract, and it is the thick paste of 1.35～1.38 (60 ℃ of mensuration) that concentrating under reduced pressure becomes relative density, and drying is ground into fine powder, and is standby; Get Radix Notoginseng, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae) and mix pulverizing 60 ℃ of dry backs with Os Draconis (calcined), Myrrha (processed), Colla Corii Asini, fine powder is standby; Sanguis Draxonis and Margarita are ground into fine powder respectively separately, with above-mentioned two fine powder mix homogeneously, add appropriate amount of starch, and the system granule adds the Borneolum Syntheticum of making fine powder again, and mixing promptly gets tablet.
Embodiment 8
By following weight weighting raw materials (unit: gram)
Radix Et Rhizoma Rhei 68, Rhizoma Coptidis 58, Radix Notoginseng 58, the Radix Angelicae Dahuricae 38, Colla Corii Asini 58, Os Draconis (calcined) 50, Pseudobulbus Bletillae (Rhizoma Bletillae) 50, Myrrha (processed) 38, Endoconcha Sepiae 50, Radix Rubiae 50, Sanguis Draxonis 18, Radix Glycyrrhizae 20, Margarita 8.
Preparation method: above medical material, get Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, add 3～8 times of amounts of 80% ethanol, the reflux secondary, each 1～3 hour, merge alcohol extract, filter, reclaim ethanol, clear paste is standby; 8～12 times of amounts of medicinal residues and Radix Rubiae and Radix Glycyrrhizae mixing and water adding decoct secondary, and each 1～3 hour, collecting decoction filtered, and mixes with above-mentioned alcohol extract, and it is the thick paste of 1.35～1.38 (60 ℃ of mensuration) that concentrating under reduced pressure becomes relative density, and drying is ground into fine powder, and is standby; Get Radix Notoginseng, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae) and mix pulverizing 60 ℃ of dry backs with Os Draconis (calcined), Myrrha (processed), Colla Corii Asini, fine powder is standby; Sanguis Draxonis and Margarita are ground into fine powder respectively separately, mix with above-mentioned two fine powders, and mixing is crossed 100 mesh sieves, promptly gets powder.
Embodiment 9
By following weight weighting raw materials (unit: kilogram)
Radix Et Rhizoma Rhei 65, Rhizoma Coptidis 50, Radix Notoginseng 50, the Radix Angelicae Dahuricae 31, Colla Corii Asini 50, Os Draconis (calcined) 44, Pseudobulbus Bletillae (Rhizoma Bletillae) 44, Myrrha (processed) 31, Endoconcha Sepiae 44, Radix Rubiae 50, Sanguis Draxonis 12, Radix Glycyrrhizae 15, Margarita 6, Borneolum Syntheticum 6.
Preparation method: above medical material, get Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, add 3～8 times of amounts of 80% ethanol, the reflux secondary, each 1～3 hour, merge alcohol extract, filter, reclaim ethanol, clear paste is standby; 8～12 times of amounts of medicinal residues and Radix Rubiae and Radix Glycyrrhizae mixing and water adding decoct secondary, and each 1～3 hour, collecting decoction filtered, and mixes with above-mentioned alcohol extract, and it is the thick paste of 1.35～1.38 (60 ℃ of mensuration) that concentrating under reduced pressure becomes relative density, and drying is ground into fine powder, and is standby; Get Radix Notoginseng, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae) and mix pulverizing 60 ℃ of dry backs with Os Draconis (calcined), Myrrha (processed), Colla Corii Asini, fine powder is standby; Sanguis Draxonis and Margarita are ground into fine powder respectively separately, with above-mentioned two fine powder mix homogeneously, add the Borneolum Syntheticum of making fine powder again, and mixing adds an amount of polyethylene glycol 6000 and magnesium stearate, makes drop pill.
Embodiment 10
By following weight weighting raw materials (unit: kilogram)
Radix Et Rhizoma Rhei 65, Rhizoma Coptidis 50, Radix Notoginseng 50, the Radix Angelicae Dahuricae 31, Colla Corii Asini 50, Os Draconis (calcined) 44, Pseudobulbus Bletillae (Rhizoma Bletillae) 44, Myrrha (processed) 31, Endoconcha Sepiae 44, Radix Rubiae 50, Sanguis Draxonis 12, Radix Glycyrrhizae 11, Margarita 4, Borneolum Syntheticum 4.
Preparation method: above medical material, get Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, add 3～8 times of amounts of 80% ethanol, the reflux secondary, each 1～3 hour, merge alcohol extract, filter, reclaim ethanol, clear paste is standby; 8～12 times of amounts of medicinal residues and Radix Rubiae and Radix Glycyrrhizae mixing and water adding decoct secondary, and each 1～3 hour, collecting decoction filtered, and mixes with above-mentioned alcohol extract, and it is the thick paste of 1.35～1.38 (60 ℃ of mensuration) that concentrating under reduced pressure becomes relative density, and drying is ground into fine powder, and is standby; Get Radix Notoginseng, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae) and mix pulverizing 60 ℃ of dry backs with Os Draconis (calcined), Myrrha (processed), Colla Corii Asini, fine powder is standby; Sanguis Draxonis and Margarita are ground into fine powder respectively separately, with above-mentioned two fine powder mix homogeneously, add the Borneolum Syntheticum of making fine powder, mixing again, be ground into pasty state with an amount of Arlacel-85, cross colloid mill with 12000rpm, get particle diameter, put in the container less than 10 μ m, add valve, sealing cap, be pressed into propellant, shake up, get powder aerosol.
Embodiment 11
By following weight weighting raw materials (unit: kilogram)
Radix Et Rhizoma Rhei 65, Rhizoma Coptidis 50, Radix Notoginseng 50, the Radix Angelicae Dahuricae 31, Colla Corii Asini 50, Os Draconis (calcined) 44, Pseudobulbus Bletillae (Rhizoma Bletillae) 44, Myrrha (processed) 31, Endoconcha Sepiae 44, Radix Rubiae 50, Sanguis Draxonis 12, Radix Glycyrrhizae 11, Margarita 4.
Preparation method: above medical material, get Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, add 3～8 times of amounts of 80% ethanol, the reflux secondary, each 1～3 hour, merge alcohol extract, filter, reclaim ethanol, clear paste is standby; 8～12 times of amounts of medicinal residues and Radix Rubiae and Radix Glycyrrhizae mixing and water adding decoct secondary, and each 1～3 hour, collecting decoction filtered, and mixes with above-mentioned alcohol extract, and it is the thick paste of 1.35～1.38 (60 ℃ of mensuration) that concentrating under reduced pressure becomes relative density, and drying is ground into fine powder, and is standby; Get Radix Notoginseng, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae) and mix pulverizing 60 ℃ of dry backs with Os Draconis (calcined), Myrrha (processed), Colla Corii Asini, fine powder is standby; Sanguis Draxonis is ground into fine powder, with above-mentioned two fine powder mix homogeneously, adds appropriate amount of starch, and the system granule sprays into the Borneolum Syntheticum with anhydrous alcohol solution again, and mixing promptly gets capsule.
Embodiment 12
By following weight weighting raw materials (unit: kilogram)
Radix Et Rhizoma Rhei 65, Rhizoma Coptidis 50, Radix Notoginseng 50, the Radix Angelicae Dahuricae 31, Colla Corii Asini 50, Os Draconis (calcined) 44, Pseudobulbus Bletillae (Rhizoma Bletillae) 44, Myrrha (processed) 31, Endoconcha Sepiae 44, Radix Rubiae 50, Sanguis Draxonis 12, Radix Glycyrrhizae 11, Borneolum Syntheticum 4.
Preparation method: above medical material, get Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, add 3～8 times of amounts of 80% ethanol, the reflux secondary, each 1～3 hour, merge alcohol extract, filter, reclaim ethanol, clear paste is standby; 8～12 times of amounts of medicinal residues and Radix Rubiae and Radix Glycyrrhizae mixing and water adding decoct secondary, and each 1～3 hour, collecting decoction filtered, and mixes with above-mentioned alcohol extract, and it is the thick paste of 1.35～1.38 (60 ℃ of mensuration) that concentrating under reduced pressure becomes relative density, and drying is ground into fine powder, and is standby; Get Radix Notoginseng, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae) and mix pulverizing 60 ℃ of dry backs with Os Draconis (calcined), Myrrha (processed), Colla Corii Asini, fine powder is standby; Sanguis Draxonis is ground into fine powder, with above-mentioned two fine powder mix homogeneously, adds appropriate amount of starch, and the system granule sprays into the Borneolum Syntheticum with anhydrous alcohol solution again, and mixing promptly gets capsule.
Embodiment 13
By following weight weighting raw materials (unit: kilogram)
Radix Et Rhizoma Rhei 65, Rhizoma Coptidis 50, Radix Notoginseng 50, the Radix Angelicae Dahuricae 31, Colla Corii Asini 50, Os Draconis (calcined) 44, Pseudobulbus Bletillae (Rhizoma Bletillae) 44, Myrrha (processed) 31, Endoconcha Sepiae 44, Radix Rubiae 50, Sanguis Draxonis 12, Margarita 4, Borneolum Syntheticum 4.
Preparation method: above medical material, get Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, add 3～8 times of amounts of 80% ethanol, the reflux secondary, each 1～3 hour, merge alcohol extract, filter, reclaim ethanol, clear paste is standby; 8～12 times of amounts of medicinal residues and Radix Rubiae mixing and water adding decoct secondary, and each 1～3 hour, collecting decoction filtered, and mixes with above-mentioned alcohol extract, and it is the thick paste of 1.35～1.38 (60 ℃ of mensuration) that concentrating under reduced pressure becomes relative density, and drying is ground into fine powder, and is standby; Get Radix Notoginseng, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae) and mix pulverizing 60 ℃ of dry backs with Os Draconis (calcined), Myrrha (processed), Colla Corii Asini, fine powder is standby; Sanguis Draxonis and Margarita are ground into fine powder respectively separately, with above-mentioned two fine powder mix homogeneously, add appropriate amount of starch, and the system granule adds the Borneolum Syntheticum of making fine powder again, and mixing promptly gets tablet.
Embodiment 14
By following weight weighting raw materials (unit: kilogram)
Radix Et Rhizoma Rhei 65, Rhizoma Coptidis 50, Radix Notoginseng 50, the Radix Angelicae Dahuricae 31, Colla Corii Asini 50, Os Draconis (calcined) 44, Pseudobulbus Bletillae (Rhizoma Bletillae) 44, Myrrha (processed) 31, Endoconcha Sepiae 44, Radix Rubiae 50, Sanguis Draxonis 12, Margarita 4.
Preparation method: above medical material, get Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, add 3～8 times of amounts of 80% ethanol, the reflux secondary, each 1～3 hour, merge alcohol extract, filter, reclaim ethanol, clear paste is standby; Medicinal residues and Radix Rubiae add 8～12 times of amounts of water, decoct secondary, and each 1～3 hour, collecting decoction filtered, and mixes with above-mentioned alcohol extract, and it is the thick paste of 1.35～1.38 (60 ℃ of mensuration) that concentrating under reduced pressure becomes relative density, and drying is ground into fine powder, and is standby; Get Radix Notoginseng, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae) and mix pulverizing 60 ℃ of dry backs with Os Draconis (calcined), Myrrha (processed), Colla Corii Asini, fine powder is standby; Sanguis Draxonis and Margarita are made fine powder, with above-mentioned two fine powder mix homogeneously, cross 100 mesh sieves, promptly get powder.
Embodiment 15
By following weight weighting raw materials (unit: kilogram)
Radix Et Rhizoma Rhei 65, Rhizoma Coptidis 50, Radix Notoginseng 50, the Radix Angelicae Dahuricae 31, Colla Corii Asini 50, Os Draconis (calcined) 44, Pseudobulbus Bletillae (Rhizoma Bletillae) 44, Myrrha (processed) 31, Endoconcha Sepiae 44, Radix Rubiae 50, Sanguis Draxonis 12, Borneolum Syntheticum 4.
Preparation method: above medical material, get Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, add 3～8 times of amounts of 80% ethanol, the reflux secondary, each 1～3 hour, merge alcohol extract, filter, reclaim ethanol, clear paste is standby; Medicinal residues and Radix Rubiae add 8～12 times of amounts of water, decoct secondary, and each 1～3 hour, collecting decoction filtered, and mixes with above-mentioned alcohol extract, and it is the thick paste of 1.35～1.38 (60 ℃ of mensuration) that concentrating under reduced pressure becomes relative density, and drying is ground into fine powder, and is standby; Get Radix Notoginseng, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae) and mix pulverizing 60 ℃ of dry backs with Os Draconis (calcined), Myrrha (processed), Colla Corii Asini, fine powder is standby; Sanguis Draxonis is made fine powder, with above-mentioned two fine powder mix homogeneously, adds the Borneolum Syntheticum of making fine powder again, and mixing adds an amount of polyethylene glycol 6000 and magnesium stearate, makes drop pill.
Embodiment 16
By following weight weighting raw materials (unit: kilogram)
Radix Et Rhizoma Rhei 65, Rhizoma Coptidis 50, Radix Notoginseng 50, the Radix Angelicae Dahuricae 31, Colla Corii Asini 50, Os Draconis (calcined) 44, Pseudobulbus Bletillae (Rhizoma Bletillae) 44, Myrrha (processed) 31, Endoconcha Sepiae 44, Radix Rubiae 50, Sanguis Draxonis 12, Radix Glycyrrhizae 11.
Preparation method: above medical material, get Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, add 3～8 times of amounts of 80% ethanol, the reflux secondary, each 1～3 hour, merge alcohol extract, filter, reclaim ethanol, clear paste is standby; Medicinal residues and Radix Rubiae and Radix Glycyrrhizae add 8～12 times of amounts of water, decoct secondary, and each 1～3 hour, collecting decoction filtered, and mixes with above-mentioned alcohol extract, and it is the thick paste of 1.35～1.38 (60 ℃ of mensuration) that concentrating under reduced pressure becomes relative density, and drying is ground into fine powder, and is standby; Get Radix Notoginseng, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae) and mix pulverizing 60 ℃ of dry backs with Os Draconis (calcined), Myrrha (processed), Colla Corii Asini, fine powder is standby; Sanguis Draxonis is made fine powder, with above-mentioned two fine powder mix homogeneously, is ground into pasty state with an amount of Arlacel-85, crosses colloid mill with 12000rpm, gets particle diameter less than 10 μ m, puts in the container, adds valve, sealing cap, is pressed into propellant, shakes up, and gets powder aerosol.
Claims (5)
1, a kind of medicine for the treatment of metrorrhagia, hematemesis and having blood in stool is characterized in that comprising following raw medicaments in portion by weight:
40～60 parts of 40～60 portions of Radix Notoginseng of 50～70 portions of Rhizoma Coptidis of Radix Et Rhizoma Rhei
30～55 parts of 40～60 parts of Os Draconis (calcined)s of 20～40 parts of Colla Corii Asini of the Radix Angelicae Dahuricae
30～55 parts of 20～40 portions of Endoconcha Sepiaes of 30～55 parts of Myrrha (processed)s of Pseudobulbus Bletillae (Rhizoma Bletillae)
10～20 parts of 40～60 parts of Sanguis Draxonis of Radix Rubiae.
2, treatment metrorrhagia as claimed in claim 1, hematemesis and the medicine of having blood in stool is characterized in that comprising following raw medicaments in portion by weight:
50 parts of 50 portions of Radix Notoginseng of 65 portions of Rhizoma Coptidis of Radix Et Rhizoma Rhei
44 parts of 50 parts of Os Draconis (calcined)s of 31 parts of Colla Corii Asini of the Radix Angelicae Dahuricae
44 parts of 31 portions of Endoconcha Sepiaes of 44 parts of Myrrha (processed)s of Pseudobulbus Bletillae (Rhizoma Bletillae)
12 parts of 50 parts of Sanguis Draxonis of Radix Rubiae.
3, treatment metrorrhagia as claimed in claim 1, hematemesis and the medicine of having blood in stool is characterized in that adding 1～10 part of 5～20 parts in Radix Glycyrrhizae and/or 1～10 part of Margarita and/or Borneolum Syntheticum in described raw material.
4, treatment metrorrhagia as claimed in claim 2, hematemesis and the medicine of having blood in stool is characterized in that adding 4 parts of 11 parts in Radix Glycyrrhizae and/or 4 parts of Margaritas and/or Borneolum Syntheticums in described raw material.
5,, it is characterized in that routinely technology and can be refined into capsule, tablet, powder, drop pill, aerosol by each dosage form requirement as claim 1,2,3 or 4 described treatment metrorrhagias, hematemesis and the medicine of having blood in stool.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100963626A CN100384463C (en) | 2005-11-17 | 2005-11-17 | Medicine for trenting flooding and spotting, haematemesis and homafecia |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100963626A CN100384463C (en) | 2005-11-17 | 2005-11-17 | Medicine for trenting flooding and spotting, haematemesis and homafecia |
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| CN100384463C CN100384463C (en) | 2008-04-30 |
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| CN101204572B (en) * | 2007-12-12 | 2010-12-15 | 胡红芳 | Preoral Chinese traditional medicine for spleen-stomach deficiency-cold hematemesis |
| CN101940721A (en) * | 2010-09-17 | 2011-01-12 | 西安千禾药业有限责任公司 | Traditional Chinese medicine for treating metrorrhagia and metrostaxis, gastrointestinal hemorrhage and traumatic hemorrhage and preparation method thereof |
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| CN102600258A (en) * | 2008-04-27 | 2012-07-25 | 李生 | Qingxin Angong pill for clearing heart fire and stopping uterine bleeding |
| CN101703690B (en) * | 2009-10-16 | 2013-01-23 | 西安千禾药业有限责任公司 | Medicament for treating metrorrhagia and metrostaxis, hematemesis, hematochezia and traumatic hemorrhage and preparation method thereof |
| CN101850101A (en) * | 2010-06-30 | 2010-10-06 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating metrostaxis and preparation method thereof |
| CN101850101B (en) * | 2010-06-30 | 2011-07-06 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating metrostaxis and preparation method thereof |
| CN101940721A (en) * | 2010-09-17 | 2011-01-12 | 西安千禾药业有限责任公司 | Traditional Chinese medicine for treating metrorrhagia and metrostaxis, gastrointestinal hemorrhage and traumatic hemorrhage and preparation method thereof |
| CN104547559A (en) * | 2013-10-25 | 2015-04-29 | 西安千禾药业有限责任公司 | Preparation method of medicinal composition Zhikang for clearing heat, cooling blood, removing blood stasis and promoting tissue regeneration |
| CN104547559B (en) * | 2013-10-25 | 2018-03-09 | 西安千禾药业有限责任公司 | A kind of preparation method of the pharmaceutical composition of clearing heat and cooling blood stagnation resolvation myogenic |
| CN105412335A (en) * | 2014-09-17 | 2016-03-23 | 李丹 | Medicine for treating uterine bleeding |
| CN105079094A (en) * | 2015-09-25 | 2015-11-25 | 孙茂志 | Traditional Chinese medicine composition for treating hemafecia |
| CN110680879A (en) * | 2019-11-08 | 2020-01-14 | 西安千禾药业股份有限公司 | Traditional Chinese medicine film spraying agent for promoting blood circulation, stopping bleeding, removing necrotic tissue and promoting granulation and preparation method thereof |
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