CN1778282A - Semiconductor refrigeration blood vessel sub-low temperature brain protection therapeutic instrument - Google Patents
Semiconductor refrigeration blood vessel sub-low temperature brain protection therapeutic instrument Download PDFInfo
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- CN1778282A CN1778282A CN 200410090420 CN200410090420A CN1778282A CN 1778282 A CN1778282 A CN 1778282A CN 200410090420 CN200410090420 CN 200410090420 CN 200410090420 A CN200410090420 A CN 200410090420A CN 1778282 A CN1778282 A CN 1778282A
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Abstract
The invention provides a semiconductor refrigeration intravascular sub-low temperature brain protection therapeutic apparatus. The therapeutic apparatus comprises an intravascular point type temperature sensing device, an infusion temperature constant temperature device, a control device and a power supply device. The intravascular point type temperature sensing device is arranged in a specific brain region, the temperature of the region is collected, and the transfusion temperature constant temperature device outputs sub-low temperature liquid which is directly transmitted to the specific brain region through a blood vessel. The control device carries out closed-loop control on the temperature of the infusion through the infusion temperature constant temperature device. The therapeutic apparatus can directly perform therapeutic action on the brain focus, has little influence on the body temperature of the whole body, can reduce or avoid complications of sub-low temperature therapy, can greatly reduce the fatality rate and the serious residual rate after cerebral infarction or brain injury, and obviously improve the prognosis of patients.
Description
Technical field
The present invention relates to a kind of brain protection therapeutic instrument, particularly a kind of inferior hypothermia cerebral protection therapeutic instrument that adopts cooling technique of semiconductor, is used for the treatment of cerebrovascular belongs to the Medical Instruments technical field.
Background technology
Current, cerebrovascular has become one of three big principal diseases that threaten human health, leaps to the first in northern China.Along with the quickening of world population senescence process, caused great society of cerebrovascular and economic problems cause the great attention of national governments.
In order effectively to prevent and the treatment cerebrovascular, often adopt anti-cerebral ischemia/dabbling again treatment means clinically.But in the process of using this treatment means, the disability rate and the case fatality rate that how to reduce Cerebral Infarction Patients become problem demanding prompt solution.For this reason, the inventor of this patent proposes associating anti-cerebral ischemia/reperfusion injury theory on zooperal basis, think that the Cerebral Ischemia damage is not the constant single cascade reaction (water fall effect) of one deck, but prolong with Ischemia Time, by light to weight, by simple to complexity, by reversible to irreversible dynamic changing process.Short time Cerebral Ischemia damage mechanism is simple, and degree is light, and this moment, single anti reperfusion injury Drug therapy was effective.And along with the prolongation of Ischemia Time, pathological tissues is in the later stage of Cerebral Ischemia damage chain, and the reperfusion injury degree increases the weight of, and mechanism is complicated, presents the positive feedback process of a plurality of reperfusion injury link fellowships, causes complicated tissue injury.Anti reperfusion injury medicine in the past is only at a certain link wherein, and is little to other all link influence, is difficult to produce significant cerebral protection.Protect the foundation of treatment means and the important directions that drug development becomes cerebral infarction research at the brain of a plurality of reperfusion injury links.
The hypothermia cerebral protection treatment is as effective brain protection treatment means, and the effect in cerebral hemorrhage and serious symptom craniocerebral injury treatment has obtained experiment and clinical confirmation.Experimentation is divided into low temperature inferior low temperature (33-36 ℃), middle low temperature (28-32 ℃) and profound hypothermia (below 27 ℃) usually.Varathan etc. discover, three kinds of degree of ischemia are to the protective effect zero difference of ischemic neuron, and middle low temperature and profound hypothermia then obviously increase the treatment complication.Therefore, inferior low temperature is the ideal temperature of brain protection treatment.
In mild hypothermia therapy, it is most important correctly to monitor the brain temperature.Applied brain temperature monitoring of former studies and cooling way comprise the direct method of measurement and the indirect method of measurement.The direct method of measurement is a kind of brain temperature monitoring method of temperature sensor directly being put into cerebral tissue, but need open cranium or boring brain essence is put in temperature sensor, the operation have traumatic, the specification requirement height, can cause part or intracranial hemorrhage, infection, be not easy to be accepted by the patient.Therefore, clinical treatment is used indirect thermometry always, being about to central vein temperature, oral temperature, ear drum membrane temperature, rectal temperature, bladder temperature, head surface temporalis temperature etc. measures, reflect the intracranial tissues temperature indirectly, but these methods have bigger measurement error (0.5 ℃～1 ℃), are difficult to embody the temperature of intracranial reality.
On the other hand, the existing ischemic tissue of brain method of temperature that reduces comprises two kinds of the inferior low temperature in external part and whole body sub-low-temperature treatments.The advantage of local mild hypothermia therapy is little to temperature influence, and complication is few.But the Pathophysiology characteristics of and ischemic tissue of brain abundant owing to scalp, temporalis and diploe blood flow, local external inferior hypothermia cerebral protection treatment are difficult to make ischemia local brain tissue temperature to be fallen to be caused inferior low temperature level, has influenced inferior hypothermia cerebral protection therapeutic effect.The temperature that can effectively reduce patient's whole body and ischemia local brain tissue is treated in whole body sub-low-temperature brain protection through intravenous route, makes patient's intracranial pressure and cerebral infarct volume reduce by 20% respectively, significantly improves patient's clinical prognosis.But cooling and rewarming process have the side effect and the severe complications of more cardiovascular system, respiratory system, blood coagulation system and nervous system aspect.Mainly contain pulmonary infection (40%), secondly increase the weight of cerebral edema for rewarming phase intracranial pressure knock-on property increases, cerebral hernia forms the main cause of rewarming phase death.Also the someone finds that more serious cardio-pulmonary function suppresses, and renal failure.In addition, the rewarming shock might take place also, therefore, the clinical practice of whole body sub-low-temperature also has been subjected to very big restriction.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, inferior hypothermia cerebral protection therapeutic instrument in a kind of novel conductor refrigeration blood vessel is provided.This therapeutic instrument can accurately be measured the temperature at specific brain regions blood supply position, and adopt cooling technique of semiconductor to the processing of lowering the temperature of treatment liquid, so that the input of the treatment liquid after will lowering the temperature vessel inner lesion nidus carries out thrombolytic, make the temperature of pathological changes cerebral tissue drop to inferior low temperature level.
For realizing above-mentioned goal of the invention, the present invention adopts following technical scheme:
Inferior hypothermia cerebral protection therapeutic instrument in a kind of conductor refrigeration blood vessel has control device, supply unit and transfusion temperature thermostat, and described control device carries out closed loop control by described transfusion temperature thermostat to the temperature of transfusion, it is characterized in that:
Described therapeutic instrument also comprises point type temperature sensing device in the blood vessel:
The point type temperature sensing device places specific brain area in the described blood vessel, gathers this regional temperature, sends described control device to; Described transfusion temperature thermostat is exported inferior cryogenic liquid, directly sends specific brain area to by blood vessel.
Described control device, supply unit and transfusion temperature thermostat are enclosed in the cabinet;
Described cabinet is divided into refrigeration portion and control part with dividing plate;
Described refrigeration portion upside is provided with low temperature chamber, and described low temperature chamber top is provided with lid, and the bottom links to each other with chiller, and locular wall is provided with the tube for transfusion import and tube for transfusion exports;
Described control part is provided with on and off switch, circuit board and two temperature controllers, and one of them temperature controller is connected with the input port of point type temperature sensing device in the described blood vessel, and another temperature controller is connected with low temperature chamber.
The point type temperature sensing device is made up of point temperature sensor, micro-wire in the described blood vessel, described point temperature sensor is positioned at the end of described micro-wire, and be coated in the encapsulating shell, it has two exits, and the lead that is connected with described exit is located in the described micro-wire.
The outside of described micro-wire has the superslide coating.
The diameter of described micro-wire is between 0.41 millimeter to 0.965 millimeter.
Has semiconductor cooler in the described transfusion temperature thermostat.
Described transfusion temperature thermostat also has main control unit, and described main control unit is controller XMTG-7000, and it controls the temperature of described refrigerator compartment.
Perhaps, described transfusion temperature thermostat also has main control unit, and described main control unit is controller PXR-4, and it controls out liquid temp.
Inferior hypothermia cerebral protection therapeutic instrument has following advantage in the conductor refrigeration blood vessel of the present invention:
1. point type temperature sensing device in the employing blood vessel directly is sent to specific cerebral blood supply arteriosomes by tremulous pulse with micro temperature sensor, the certainty of measurement height, and can reflect exactly the filling temperature of local brain tissue has even more ideal directive significance for treatment.
2. adopt microinvasion neurosurgery technology, by inserting microtubular to intracranial large artery trunks pathological changes nidus from femoral artery, the treatment liquid that input is handled through cooling carries out thrombolytic, continue behind the thrombolytic in ischemic tissue of brain, to pour into cryogenic liquid, make the temperature of pathological changes cerebral tissue drop to inferior low temperature level by logical again feeding artery.Because therapeutical effect is directly taken place in focus, very little to the temperature influence of whole body, therefore can reduce or avoid the mild hypothermia therapy complication, can reduce case fatality rate and severe disability rate behind cerebral infarction or the brain injury greatly, obviously improve patient's prognosis.
Description of drawings
The present invention is further illustrated below in conjunction with the drawings and specific embodiments.
Fig. 1 to Fig. 4 is the outward appearance and the structural representation of inferior hypothermia cerebral protection therapeutic instrument in this conductor refrigeration blood vessel.
Fig. 5 is the structural representation of point type temperature sensing device in the blood vessel.
Fig. 6 is the generalized section of point type temperature sensing device in the blood vessel.
Fig. 7 is the operation principle sketch map of semiconductor cooler.
Fig. 8 is the circuit theory diagrams of temperature-control circuit.
Fig. 9 is the schematic block circuit diagram of the transfusion temperature thermostat of employing semiconductor cooler.
Figure 10 is the control sketch map of inferior hypothermia cerebral protection therapeutic instrument in this conductor refrigeration blood vessel.
Figure 11 is an examples of circuits figure that can realize the control device in the inferior hypothermia cerebral protection therapeutic instrument in this conductor refrigeration blood vessel.
The specific embodiment
Fig. 1 to Fig. 4 is the outward appearance and the structural representation of inferior hypothermia cerebral protection therapeutic instrument in the conductor refrigeration blood vessel of the present invention.Inferior hypothermia cerebral protection therapeutic instrument mainly comprises several parts such as point type temperature sensing device in the blood vessel, transfusion temperature thermostat, control device, supply unit in this conductor refrigeration blood vessel.The temperature sensing device 3, remaining all device all is enclosed in the closed case in blood vessel.With reference to shown in Figure 1, this cabinet is divided into control part 1 and refrigeration portion 2 by dividing plate.Have on and off switch 12, temperature controller 11 and control circuit board (not shown) in the control part 1.Refrigeration portion 2 upsides are provided with low temperature chamber 212, and its lid 211 flexibly connects by hinge 5 and casing.The low temperature chamber sidewall is provided with tube for transfusion import 214 and tube for transfusion outlet 215, and low temperature chamber is designed to circle, can spiral for tube for transfusion to place wherein (with reference to Fig. 4).Low temperature chamber bottom 213 is connected with mini fan 22 with fin, with the employing wind cooling temperature lowering.The casing front of cabinet has the display floater 11 of temperature control usefulness, but displays temperature and carry out manual adjustments.Box back surface is provided with power line 15 and is provided with data-out port 14, and data-out port 14 can be for being connected with other external equipments.The sidewall of cabinet is provided with the heat radiation barrier, helps quick heat radiating.This therapeutic instrument is by the 3 induction local cerebral blood flow temperature of temperature sensing device in the blood vessel and this regional temperature is fed back to control part 1 and refrigeration portion 2, and on display floater 11, show with digital form, match by single-chip microcomputer and refrigeration portion in the control part 1, the temperature that can adjust input liquid automatically is so that reach medical desired temperature.
According to purpose of the present invention, the function that the present invention realized mainly contains two, and one is that the set point temperature of brain specific region is measured, and another is to provide to this specific region to carry out dabbling cryogenic liquid.For this reason, the Core Feature device of inferior hypothermia cerebral protection therapeutic instrument comprises point type temperature sensing device in the blood vessel in this conductor refrigeration blood vessel, and it is used to realize the one-point measurement to specific cerebral blood supply arteriosomes, with the filling temperature of accurate reflection local brain tissue; Transfusion temperature thermostat, it is with being engaged in the dabbling microinvasion neurosurgery of cryogenic liquid equipment, and is to the specific region of brain perfusion cryogenic liquid, stifled and make the temperature of pathological changes cerebral tissue drop to the purpose of inferior low temperature level to reach dissolving cerebral vessels bolt.
Respectively point type temperature sensing device in the above-mentioned blood vessel and transfusion temperature thermostat are described in detail below.
The point type temperature sensing device is with reference to Fig. 5 and shown in Figure 6 in the blood vessel, and point temperature sensor 31 is positioned at the end of micro-wire 32, and is coated in the encapsulating shell, and it has two exits.The lead 33 that is connected with exit is located in the micro-wire 32, and it is the certain flexible body of a softness and tool, and its diameter is between 0.41 millimeter to 0.965 millimeter, and length can be 1 meter to 2 meters.Have superslide coating 34 in the outside of micro-wire 32,, and in conduit, carry easily, avoid injured blood vessel simultaneously so that by crooked intracranial vessel.Above-mentioned point temperature sensor comes down to a thermocouple, and its length preferably should be in 1mm.As existing mature technology, do not describe in detail at this.Micro-wire 32 with superslide coating 34 can adopt the multiple product in the existing medical science intervening equipment, as 3F/4F/5F/7F superslide Misgurni anguillicaudati seal wire (MeritMedica) etc.In the specific implementation, the diameter of this micro-wire head end 15cm should be below 0.67mm, and softness and flexible, with support force.For this reason, it can adopt the zinc-plated or copper covered steel lead-in wire of copper, and point temperature sensor arrives middle cerebral artery by tortuous internal carotid artery in the blood vessel to advance, or arrives basilar artery by tortuous vertebral artery.When treatment; behind femoral artery puncture placement guiding catheter; through guiding catheter head end is had that the micro-wire of point temperature sensor places in people's brain medium-sized artery or the basilar artery in the blood vessel; induction local cerebral blood flow temperature also feeds back to this regional temperature the control panel 11 of inferior hypothermia cerebral protection therapeutic instrument in the blood vessel; and with the digital form demonstration, the temperature that can adjust input liquid automatically is so that reach medical desired temperature.
Because the micro-wire 32 of above-mentioned point temperature sensor 31 has certain toughness, can pass through tortuous blood vessel, but also not too hard, in order to avoid the intravital blood vessel of damage machine.The mensuration trueness error of temperature sensor should be controlled in 0.1 ℃, can accurately monitor the temperature of local brain tissue.Placing the head end of specific brain regions angiosomes to have the micro-wire of temperature sensor can be through using more than 20 times behind the medical disinfecting repeatedly.
The core of transfusion temperature thermostat is a semiconductor cooler.This semiconductor cooler is close to the tube for transfusion shown in Fig. 4, to reduce the temperature of treatment liquid.So-called conductor refrigeration is named thermoelectric cooling again, is the application of peltier effect aspect cooling technic.Practical thermoelectric cooling device be by pyroelectric effect relatively significantly, thermoelectric cooling efficient constitutes than higher semiconductor thermocouple.
With reference to shown in Figure 7, a p type semiconductor subassembly and a n type semiconductor subassembly connect into thermocouple, connect dc source after, the transfer that will produce the temperature difference and heat in the joint.A superincumbent joint, the sense of current is n → p, temperature descends and heat absorption, Here it is cold junction.A joint below, the sense of current is p → n, temperature rises and heat release, is the hot junction therefore.Semiconductor thermocouple being contacted some by this figure, then is in parallel aspect heat transfer, and this has just constituted a common refrigerant thermopile.After connecting dc source by diagram, being cold junction above this thermoelectric pile, is the hot junction below.By various heat transfer means such as heat exchangers, constantly dispelled the heat in the hot junction of thermoelectric pile and keep certain temperature, the cold junction of thermoelectric pile is put into removes absorbing and cooling temperature in the working environment, the operation principle of Here it is thermoelectric cooling module.
From above-mentioned principle explanation as can be seen, the thermoregulation of semiconductor cooler can achieve the goal by the electric current input of controlling this refrigerator.For this reason, can adopt as shown in Figure 8 temperature-control circuit.In this circuit, semiconductor cooler is started working during switch closure.Light emitting diode flashes simultaneously, represents that all are working properly.R1 is a negative temperature coefficient 5K critesistor, and promptly its resistance reduces when temperature rises, and it directly is attached on the semiconductor freezer cold end, when refrigerator was started working, cold junction temperature descended, and R1 resistance rises, the R4 both end voltage descends, and 2 terminal voltages rise, and outfan is a low level when being raised to 2/3UCc, cooling stops, at this moment, temperature is slightly gone up, and R1 resistance begins to descend, the R4 both end voltage rises, 2 terminal voltages descend, and when dropping to 1/3UCc, are output as high level, continue cooling, so move in circles, reach temperature controlled purpose, like this, semiconductor cooler can be saved the part electric energy also with discontinuous operation.The size that act as micro actuator adjusting resistance of 10k Ω potentiometer R2 changes the temperature that electric current reaches to be needed.Each transistor is the amplified current effect in the circuit.Two-way switch K3 controls refrigeration by the direction that changes electric current inflow refrigerator.
Figure 9 shows that the schematic block circuit diagram of the transfusion temperature thermostat that adopts above-mentioned semiconductor cooler.Main control unit has two kinds of implementations, and wherein scheme one is a temperature of controlling refrigerator compartment with controller XMTG-7000, and scheme two is to control out liquid temp with controller PXR-4.It is connected with external master control thermoregulator R1, has alarm unit, this unit to be connected with warning temperature-control senser R2 on the main control unit next door.Main control unit and alarm unit side input civil power, civil power enters overtemperature power-off control circuit as shown in Figure 8 through after the transformator transformation, is connected with the refrigeration power supply through this circuit, thereby realizes the refrigerator temperature controlling.Above-mentioned main control unit and alarm unit have input temperature of liquid controling mechanism, it is supercool can not occur importing liquid, after measured blood heat exceeds safety range, audible alarm can occur, and adjust the input temperature of liquid automatically, in order to avoid the patient is caused unexpected injury.
When using the present invention to carry out the inferior cryogenic liquid perfusion of brain, also need to use and carry out cryogenic liquid dabbling microinvasion neurosurgery equipment such as guiding catheter, microtubular, infusion flow control appliance etc.The prior art means that these equipment can both be grasped as the general medical worker of neurosurgery have not just described in detail one by one at this.
As shown in figure 10, inferior hypothermia cerebral protection therapeutic instrument adopts loop control theory in this conductor refrigeration blood vessel.Control device is core with the single-chip microcomputer, object such as temperature of liquid are respectively controlled in each temperature sensor collection, the data of blood vessel temperature etc., the data of gathering send back single-chip microcomputer through relay and transmitter, and handle by the control sequence of single-chip microcomputer inside, to realize closed loop control to control objects such as temperature of liquid.
Above-mentioned control device can adopt multiple concrete circuit to realize.Figure 11 has provided a physical circuit that can be used to realize above-mentioned control device.It is by single-chip microcomputer, address latch IC1, analog gate IC circuit 2, static memory IC3, EPROM IC4, E
2PROM IC5, amplifying circuit IC8 etc. partly form.Single-chip microcomputer is 8XC552, and it comprises arithmetical unit, controller and A/D converter.Each road temperature signal is after the AD521 amplifier amplifies, again through the V/F conversion, convert this voltage signal to frequency signal, receive the T0 end of single-chip microcomputer, after signals collecting is finished, the control sequence that calls among the IC5 calculates each road signal, obtains the closed loop control result at last, and the result sends control instruction to temperature-control circuit etc. according to control.In addition, above-mentioned single-chip microcomputer also has serial communication interface, and this interface is connected on the data-out port 14 of above-mentioned cabinet, so that host computer communicates.
Inferior hypothermia cerebral protection therapeutic instrument can carry out the auxiliary treatment of cerebrovascular disease in the conductor refrigeration blood vessel provided by the present invention.Its concrete using method is: after femoral artery puncture is placed guiding catheter, through guiding catheter head end is had that the micro-wire of point temperature sensor places in people's brain medium-sized artery or the basilar artery in the blood vessel, thereby can accurately reflect the filling temperature of local brain tissue.Cryogenic liquid is by inserting microtubular to intracranial large artery trunks pathological changes nidus from femoral artery, the treatment liquid that input is handled through cooling carries out thrombolytic, continue behind the thrombolytic in ischemic tissue of brain, to pour into cryogenic liquid by logical again feeding artery, make the temperature of pathological changes cerebral tissue drop to inferior low temperature level, realize the even decline of pathological changes cerebral tissue temperature.Because therapeutical effect is directly taken place in focus, and very little to the temperature influence of whole body, therefore can reduce or avoid the mild hypothermia therapy complication, can reduce case fatality rate and severe disability rate behind cerebral infarction or the brain injury greatly, obviously improve patient's prognosis.
Specific embodiment of the present invention has been done detailed explanation to content of the present invention.For one of ordinary skill in the art, any conspicuous change that it is done without departing from the premise in the spirit of the present invention particularly to the replacement that is equal to of some parts, all constitutes to infringement of patent right of the present invention, with corresponding legal responsibilities.
Claims (8)
1. the interior inferior hypothermia cerebral protection therapeutic instrument of conductor refrigeration blood vessel has control device, supply unit and transfusion temperature thermostat, and described control device carries out closed loop control by described transfusion temperature thermostat to the temperature of transfusion, it is characterized in that:
Described therapeutic instrument also comprises point type temperature sensing device in the blood vessel;
The point type temperature sensing device places specific brain area in the described blood vessel, gathers this regional temperature, sends described control device to;
Described transfusion temperature thermostat is exported inferior cryogenic liquid, directly sends specific brain area to by blood vessel.
2. inferior hypothermia cerebral protection therapeutic instrument in the conductor refrigeration blood vessel as claimed in claim 1 is characterized in that:
Described control device, supply unit and transfusion temperature thermostat are enclosed in the cabinet;
Described cabinet is divided into refrigeration portion and control part with dividing plate;
Described refrigeration portion upside is provided with low temperature chamber, and described low temperature chamber top is provided with lid, and the bottom links to each other with chiller, and locular wall is provided with the tube for transfusion import and tube for transfusion exports;
Described control part is provided with on and off switch, circuit board and two temperature controllers, and one of them temperature controller is connected with the input port of point type temperature sensing device in the described blood vessel, and another temperature controller is connected with low temperature chamber.
3. inferior hypothermia cerebral protection therapeutic instrument in the conductor refrigeration blood vessel as claimed in claim 1 is characterized in that:
The point type temperature sensing device is made up of point temperature sensor, micro-wire in the described blood vessel, described point temperature sensor is positioned at the end of described micro-wire, and be coated in the encapsulating shell, it has two exits, and the lead that is connected with described exit is located in the described micro-wire.
4. inferior hypothermia cerebral protection therapeutic instrument in the conductor refrigeration blood vessel as claimed in claim 3 is characterized in that:
The outside of described micro-wire has the superslide coating.
5. inferior hypothermia cerebral protection therapeutic instrument in the conductor refrigeration blood vessel as claimed in claim 3 is characterized in that:
The diameter of described micro-wire is between 0.41 millimeter to 0.965 millimeter.
6. inferior hypothermia cerebral protection therapeutic instrument in the conductor refrigeration blood vessel as claimed in claim 1 is characterized in that:
Has semiconductor cooler in the described transfusion temperature thermostat.
7. inferior hypothermia cerebral protection therapeutic instrument in the conductor refrigeration blood vessel as claimed in claim 6 is characterized in that:
Described transfusion temperature thermostat also has main control unit, and described main control unit is controller XMTG-7000, and it controls the temperature of described refrigerator compartment.
8. inferior hypothermia cerebral protection therapeutic instrument in the conductor refrigeration blood vessel as claimed in claim 6 is characterized in that:
Described transfusion temperature thermostat also has main control unit, and described main control unit is controller PXR-4, and it controls out liquid temp.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410090420 CN1778282A (en) | 2004-11-18 | 2004-11-18 | Semiconductor refrigeration blood vessel sub-low temperature brain protection therapeutic instrument |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410090420 CN1778282A (en) | 2004-11-18 | 2004-11-18 | Semiconductor refrigeration blood vessel sub-low temperature brain protection therapeutic instrument |
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| CN1778282A true CN1778282A (en) | 2006-05-31 |
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| CN 200410090420 Pending CN1778282A (en) | 2004-11-18 | 2004-11-18 | Semiconductor refrigeration blood vessel sub-low temperature brain protection therapeutic instrument |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101744682B (en) * | 2009-06-24 | 2011-04-20 | 中国科学院自动化研究所 | Intravascular automatic temperature regulation instrument |
| CN102512734A (en) * | 2011-12-29 | 2012-06-27 | 武汉大学 | Portable automatic mild hypothermia instrument with ice salt water |
| CN102727338A (en) * | 2012-07-11 | 2012-10-17 | 首都医科大学 | Brain fixed-point sub-hypothermia control device |
| CN104288896A (en) * | 2014-06-25 | 2015-01-21 | 首都医科大学 | Portable box for crania-cerebral perfusion cooling |
-
2004
- 2004-11-18 CN CN 200410090420 patent/CN1778282A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101744682B (en) * | 2009-06-24 | 2011-04-20 | 中国科学院自动化研究所 | Intravascular automatic temperature regulation instrument |
| CN102512734A (en) * | 2011-12-29 | 2012-06-27 | 武汉大学 | Portable automatic mild hypothermia instrument with ice salt water |
| CN102512734B (en) * | 2011-12-29 | 2013-09-11 | 武汉大学 | Portable automatic mild hypothermia instrument with ice salt water |
| CN102727338A (en) * | 2012-07-11 | 2012-10-17 | 首都医科大学 | Brain fixed-point sub-hypothermia control device |
| CN104288896A (en) * | 2014-06-25 | 2015-01-21 | 首都医科大学 | Portable box for crania-cerebral perfusion cooling |
| CN104288896B (en) * | 2014-06-25 | 2017-11-14 | 首都医科大学 | A kind of cranium brain perfusion cooling carrying case |
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