CN102727338A - Brain fixed-point sub-hypothermia control device - Google Patents
Brain fixed-point sub-hypothermia control device Download PDFInfo
- Publication number
- CN102727338A CN102727338A CN2012102384295A CN201210238429A CN102727338A CN 102727338 A CN102727338 A CN 102727338A CN 2012102384295 A CN2012102384295 A CN 2012102384295A CN 201210238429 A CN201210238429 A CN 201210238429A CN 102727338 A CN102727338 A CN 102727338A
- Authority
- CN
- China
- Prior art keywords
- liquid
- control device
- brain
- insertion type
- type conduit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Abstract
The invention relates to a brain fixed-point sub-hypothermia control device. The brain fixed-point sub-hypothermia control device comprises an intrusive guide tube, temperature detection elements, a control system, a liquid cooling device and a liquid pushing device, wherein the temperature detection elements (2, 2') are used for respectively monitoring the temperatures of an inlet and an outlet of the intrusive guide tube (1); the temperature detection element (2'') is used for monitoring the temperature of the output cooling liquid of the liquid cooling device (4); and the control system (3) is used for sending a control signal to start the liquid pushing device (5) to push the cooled liquid into the inlet of the intrusive guide tube at a certain speed. With the adoption of the brain fixed-point sub-hypothermia control device, the brain cooling part can be accurately positioned, the cooling process is timely and quick, and the sub-hypothermia state can be accurately and reliably maintained; in addition, acute and serious cerebral edema can be controlled, and conditions are created for promoting recovery of brain function, so that the brain fixed-point sub-hypothermia control device plays an important role in reducing fatality rate and disability rate.
Description
Technical field:
The present invention relates to the inferior low temperature control device of a kind of brain fixed point, particularly relate to a kind of inferior low temperature control device of part fixed point that in time carries out the brain function protection to cerebral hemorrhage, Heavy craniocerebral injury patient.
Background technology:
Cerebral hemorrhage, Heavy craniocerebral injury are fatality rate and the very high disease of disability rate, and patient's cerebral tissue receives in various degree and destroying, and hyperpyrexia, vascular permeability increase cause cerebral edema and cerebral ischemia, and untimely processing will promote the vicious cycle of intracranial hypertension.
Research shows, inferior low temperature (33-35 ℃) can prevent the hyperpyrexia that causes owing to cerebral lesion, can behind cerebral hemorrhage, reduce the oxygen consumption of brain cell; Improve brain cell to anoxybiotic toleration, can reduce the basal metabolism of cerebral tissue again, alleviate brain injury hindbrain tissue acidosis degree; The protection blood brain barrier alleviates, prevents the generation and the development of cerebral edema, has the effect of the intracranial pressure of reduction; Reduce the neurocyte structural deterioration, promote brain function to recover, alleviate nerve cell death; Thereby can significantly alleviate the infringement of cerebral ischemia and brain injury hindbrain form and function, the defective of having avoided the profound hypothermia therapy to exist simultaneously.Also have hemostasis, promote mind to recover, make functions such as heart rate, respiratory frequency slow down, blood pressure drops.
Within cerebral hemorrhage, Heavy craniocerebral injury patient fell ill 6-8 hour; Carry out inferior cryotherapy as early as possible; Can significantly alleviate delayed ischemic neurological deficits and the infringement of encephalopathy reason form behind the cerebral hemorrhage, improve the prognosis of patients with cerebral hemorrhage function of nervous system, reduce patient's case fatality rate and disability rate.
Existing mild hypothermia therapy technology can be divided into two types of intrusive mood and non-intrusion types; The intrusive mood falling temperature technique comprises cooling in extracorporeal circulation cooling blood techniques, the blood vessel, irrigation of rectum, peritoneal lavage etc., and the non-intrusion type falling temperature technique comprises ice bag, ice cap, ice blanket, wipes of alcohol examination etc.The former can make the body reflection produce muscle twitches because of whole body body temperature descends usually, causes energy metabolism to raise, and influence is breathed and circulation; The latter's cooling rate is slow, and low temperature state is non-constant, and not being suitable for needs the inferior cryogenic disease of rapid induction.
Summary of the invention:
Main purpose of the present invention is the principle according to heat exchange falling temperature technique in the cerebral vessels, design a kind of can accurately control the brain temperatures at localized regions, in time intervene PD, slow down the inferior low temperature control device of brain fixed point that brain cell infringement and apoptosis, promotion brain function recover.
This instrument comprises insertion type conduit, detector unit, control system, Control device of liquid cooling, liquid thrust unit.
Shown in accompanying drawing 1, detector unit 2 and detector unit 2 ' monitor inlet, the exit temperature of insertion type conduit 1 respectively, and transmission feeds back signal to control system 3 in real time.When reaching or runaway, detector unit 2 ' monitor exit temperature goes up in limited time; This temperature range can be set between 33-35 ℃; Detector unit 2 ' signal feedback is arrived control system 3; Control system 3 is sent control signal start liquid chiller 4, and to temperature controlling range, " monitoring is by the temperature of Control device of liquid cooling 4 output cooling liquids; and temperature signal fed back to control system 3; control system 3 is sent control signal start liquid thrust unit 5 simultaneously, and liquid thrust unit 5 will pass through Control device of liquid cooling 4 refrigerative liquid and push the inlet of conduit 1 with given pace, and detector unit 2 temperature of monitoring liquid thrust unit 5 output cooling liquids simultaneously also feeds back to control system 3 for detector unit 2 with liquid cools.Detector unit 2, detector unit 2 ' and detector unit 2 " form feedback respectively with control system 3.
Shown in accompanying drawing 2, the main effect of the head 6 of insertion type conduit 1 is to carry out heat exchange, therefore will select the big and nontoxic material of heat conductivity for use, like silver, gold etc.; The root 7 of insertion type conduit has two branches, is respectively entrance and exit, connects liquid thrust unit 5 and Control device of liquid cooling 4 successively; The adiabatic material of biological adaptation is selected at the head 6 and the position 8 between the root 7 of insertion type conduit 1 for use; And the vertical section 9 that useful adiabator is processed in the middle of the conduit; Can liquid and the effusive liquid of conduit outlet that duct entry flows into be kept apart, and not carry out exchange heat.
Further improve; Can carry out insertion type conduit 1 through peripheral control circuit test experiments, the experiment of conduit Characteristics Detection, biological tissue's experiment, animal and clinical experiment; Obtaining with the catheter head is the temperature field data at center, sets up the relation between inlet, 2 temperature in exit, flow rate of liquid and the catheter head temperature field.When selected coolant temperature during 21 ℃ of left and right sides, flow rate of liquid is fast more, and it is short more that the central temperature of insertion type conduit 1 head reaches 33 ℃ of required times; Flow rate of liquid is slow more, and it is long more that insertion type conduit 1 central temperature reaches 33 ℃ of required times, but the radiation scope of cooling is wide more, reaches radius and be 2 centimetres border circular areas.
The invention has the beneficial effects as follows: within cerebral hemorrhage, Heavy craniocerebral injury patient fell ill 6-8 hour; Adopt the inferior low temperature control device of brain fixed point as early as possible; Carry out inferior cryotherapy, can realize that not only brain cooling location is accurate, cooling is timely and speed is fast, keep inferior low temperature accurately and reliably, and can control acute serious cerebral edema; For the promotion brain function recovers to have created condition, thereby reduction case fatality rate, minimizing disability rate are played an important role.Simultaneously, owing to alleviated cerebral edema, the relative medicine consumption reduces, and the toxic and side effects of renal function injury is also corresponding to be reduced, and helps prolonging the operation rescue time, improves salvage success rate.Method is reliable, operation is simple, is worth clinical expansion to use.
Description of drawings:
Accompanying drawing 1 is a theory diagram of the present invention;
Accompanying drawing 2 is insertion type conduit sketch maps of the present invention;
Accompanying drawing 3 is the program flow diagram of control system;
Accompanying drawing 4 is the interactive interface of control system;
Accompanying drawing 5 is part experiment test result.
The specific embodiment:
1,2,3,4 and 5 pair of technical scheme of the present invention is done further explanation below with reference to accompanying drawings.
Shown in accompanying drawing 1, during treatment, insertion type conduit 1 is sent into through femoral artery puncture, leads down at fine definition X line power traction, and conduit is placed the blood vessel of brain tremulous pulse, the nearer position of chosen distance cerebral hemorrhage or brain injury position as far as possible.Cooling liquid gets into the inlet of conduits through liquid thrust unit 5, arrives the head of conduit again, fully contacts with blood in the brain arteries and carries out heat exchange.
Control device of liquid cooling 4 can be selected fine semiconductor refrigerating element for use, constitutes thermoelectric pile commonly used to some thermocouple is coupled together, by the heat transfer device; Make the hot-side heat dissipation of thermoelectric pile; And keep certain temperature, and be put into the cold junction of thermoelectric pile and go heat absorption in the Control device of liquid cooling, produce low temperature.
Control device of liquid cooling 4 also can adopt water route or oil circuit outer circulation refrigerating method to carry out the cooling of liquid in the conduit, produces low temperature.Or adopt above-mentioned semiconductor refrigerating element and the refrigerating compound mode of outer circulation to carry out the cooling of liquid in the conduit.
Liquid thrust unit 5 can be selected the controlled peristaltic pump of flow velocity for use, makes through roller repeated compression elastic tube that liquid moves towards certain orientation in the pipe.The program flow diagram of control system 3 is shown in accompanying drawing 3, and SCM system begins initialization and is 30 with the peristaltic pump parameter setting, and corresponding maximum rate 24ml/min, peristaltic pump begin with rapid rate work, and display lamp lights.After central temperature reached 33 ℃, peristaltic pump was 3ml/min with changing down to a certain particular value like rate parameter 240 rate corresponding, fluctuate between 33-34 ℃ so that keep central temperature, and environment temperature continued to approach to central temperature.After central temperature is lower than 32 ℃, peristaltic pump will quit work, and above numerical value records by experiment.
Write the interactive interface of control system 3 with LABVIEW, shown in accompanying drawing 4, when initialization, can set the speed of cooling liquid; Be the infusion rate in the accompanying drawing 4, and the temperature of cooling liquid, i.e. parameters such as temperature 1 in the accompanying drawing 4; Show simultaneously on the interactive interface that insertion type conduit 1 head respectively monitors the temperature field data and the wave form varies at position; Temperature 2 is a central temperature, and temperature 3 is the medium temperature of distance center 2 centimeters, and temperature 4 is the outer rim temperature of distance center 4 centimeters.
Recorded by experiment, the cooling speed is at first relevant with coolant temperature.Through the tests of a large amount of experiments, we both can meet the demands about 21 ℃ at selected coolant temperature, can reduce chilled liquid temperature again and cross low the discomfort of bringing to patient.As shown in Figure 5: after beginning to lower the temperature 170 seconds under the situation that with speed is 24ml/min, the central temperature of insertion type conduit 1 head is reduced to 33 ℃ of target temperatures, and does not almost reduce apart from the medium temperature of its 2 centimeters; After beginning to lower the temperature 150 seconds under the situation that with speed is 12.6ml/min, the central temperature of insertion type conduit 1 head is reduced to 33 ℃ of target temperatures, and begins to decrease apart from the medium temperature at its 2cm place; After beginning to lower the temperature 260 seconds under the situation that with speed is 6.4ml/min, the central temperature of insertion type conduit 1 head is reduced to 33 ℃ of target temperatures, and apart from the medium temperature at its 2cm place reduce more obvious; After beginning to lower the temperature 800 seconds under the situation that with speed is 3ml/min; The central temperature of insertion type conduit 1 head is reduced to 33 ℃ of target temperatures; And be reduced to below 35 ℃ apart from the medium temperature at its 2cm place; Be under the situation of 3ml/min promptly, no longer reduce after central temperature drops to 33 ℃, and environment temperature still can continue to approach 33 ℃ in infusion rate.
Claims (7)
1. the inferior low temperature control device of brain fixed point comprises: insertion type conduit (1), detector unit (2,2 ', 2 "), control system (3), Control device of liquid cooling (4), liquid thrust unit (5) is characterized in that:
Said insertion type conduit (1) fully contacts with blood in the brain arteries and carries out heat exchange;
Said detector unit (2,2 ', 2 ") are monitored the temperature in insertion type conduit (1) inlet, outlet and Control device of liquid cooling (4) exit respectively, and transmission feeds back signal to control system (3) in real time;
Said Control device of liquid cooling (4) arrives the predefined temperature of control system (3) with liquid cools;
Said liquid thrust unit (5) will pass through the refrigerative liquid of Control device of liquid cooling (4) and push insertion type conduit (1) inlet with given pace;
Said control system (3) is according to detector unit (2; 2 '; 2 " feedback signal) is monitored temperature of liquid in real time; and according to insertion type conduit (1) inlet, exit temperature, start or stop liquid thrust unit (5), the blood heat of carrying out heat exchange until the head (6) with insertion type conduit (1) reaches the inferior low temperature of target.
2. the inferior low temperature control device of brain fixed point according to claim 1 is characterized in that: head (6) the employing heat conductivity of said insertion type conduit (1) is big, the material of biocompatibility; The head (6) of insertion type conduit (1) and the position (8) between the root (7) are with material adiabatic, biocompatibility.
3. the inferior low temperature control device of brain fixed point according to claim 2, it is characterized in that: the root (7) of said insertion type conduit (1) has two branches, is respectively entrance and exit, connects liquid thrust unit (5) and Control device of liquid cooling (4) successively; The vertical section (9) that useful adiabator is processed in the middle of the said insertion type conduit (1) can be kept apart liquid and the effusive liquid of conduit outlet that duct entry flows into.
4. the inferior low temperature control device of brain fixed point according to claim 1; It is characterized in that: Control device of liquid cooling (4) adopts the semiconductor refrigerating element; Perhaps adopt water route or oil circuit outer circulation refrigeration, perhaps adopt semiconductor refrigerating element and water route or the refrigerating combination of oil circuit outer circulation.
5. the inferior low temperature control device of brain fixed point according to claim 1, it is characterized in that: described liquid thrust unit (5) is the controlled peristaltic pump of flow velocity.
6. the inferior low temperature control device of brain fixed point according to claim 5, it is characterized in that: said control system (3) adopts the C8051F021 described liquid thrust unit of Single-chip Controlling (5).
7. according to the inferior low temperature control device of the described brain fixed point of one of claim 1-6, it is characterized in that: the temperature of said liquid is 21 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102384295A CN102727338A (en) | 2012-07-11 | 2012-07-11 | Brain fixed-point sub-hypothermia control device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102384295A CN102727338A (en) | 2012-07-11 | 2012-07-11 | Brain fixed-point sub-hypothermia control device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102727338A true CN102727338A (en) | 2012-10-17 |
Family
ID=46984120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012102384295A Pending CN102727338A (en) | 2012-07-11 | 2012-07-11 | Brain fixed-point sub-hypothermia control device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102727338A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417325A (en) * | 2013-08-26 | 2013-12-04 | 中国医学科学院生物医学工程研究所 | Mild hypothermia therapy-endovascular heat exchange temperature adjustment control device |
| CN104288896A (en) * | 2014-06-25 | 2015-01-21 | 首都医科大学 | Portable box for crania-cerebral perfusion cooling |
| CN104473714A (en) * | 2014-12-08 | 2015-04-01 | 刘思伯 | Extravascular cooling and mild hypothermia treatment control system and application thereof |
| CN104546279A (en) * | 2015-01-05 | 2015-04-29 | 张茂 | Body cooling device |
| CN107981968A (en) * | 2017-12-29 | 2018-05-04 | 无锡圣诺亚科技有限公司 | Portable temperature control physical therapy device |
| CN108814803A (en) * | 2018-06-14 | 2018-11-16 | 中国医学科学院生物医学工程研究所 | A kind of body temperature regulation method, apparatus, equipment and storage medium |
| CN111481335A (en) * | 2019-01-28 | 2020-08-04 | 深圳市科曼医疗设备有限公司 | Human body temperature adjusting method and device and sub-hypothermia treatment equipment |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001093922A1 (en) * | 2000-06-05 | 2001-12-13 | Argmed Kommanditbolag | Method and apparatus for cerebral tempering |
| WO2005117778A1 (en) * | 2004-05-26 | 2005-12-15 | Ardiem Medical, Inc. | Apparatus and method for inducing suspended animation using rapid, whole body, profound hypothermia |
| CN1778282A (en) * | 2004-11-18 | 2006-05-31 | 首都医科大学宣武医院 | Subhypothermic brain-protection therapeutic device in semiconductor cryogenic blood vessel |
| JP2008154751A (en) * | 2006-12-22 | 2008-07-10 | Osaka Industrial Promotion Organization | Low-temperature treating device |
-
2012
- 2012-07-11 CN CN2012102384295A patent/CN102727338A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001093922A1 (en) * | 2000-06-05 | 2001-12-13 | Argmed Kommanditbolag | Method and apparatus for cerebral tempering |
| WO2005117778A1 (en) * | 2004-05-26 | 2005-12-15 | Ardiem Medical, Inc. | Apparatus and method for inducing suspended animation using rapid, whole body, profound hypothermia |
| CN1778282A (en) * | 2004-11-18 | 2006-05-31 | 首都医科大学宣武医院 | Subhypothermic brain-protection therapeutic device in semiconductor cryogenic blood vessel |
| JP2008154751A (en) * | 2006-12-22 | 2008-07-10 | Osaka Industrial Promotion Organization | Low-temperature treating device |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417325A (en) * | 2013-08-26 | 2013-12-04 | 中国医学科学院生物医学工程研究所 | Mild hypothermia therapy-endovascular heat exchange temperature adjustment control device |
| CN103417325B (en) * | 2013-08-26 | 2015-04-01 | 中国医学科学院生物医学工程研究所 | Mild hypothermia therapy-endovascular heat exchange temperature adjustment control device |
| CN104288896A (en) * | 2014-06-25 | 2015-01-21 | 首都医科大学 | Portable box for crania-cerebral perfusion cooling |
| CN104473714A (en) * | 2014-12-08 | 2015-04-01 | 刘思伯 | Extravascular cooling and mild hypothermia treatment control system and application thereof |
| CN104546279A (en) * | 2015-01-05 | 2015-04-29 | 张茂 | Body cooling device |
| CN107981968A (en) * | 2017-12-29 | 2018-05-04 | 无锡圣诺亚科技有限公司 | Portable temperature control physical therapy device |
| CN108814803A (en) * | 2018-06-14 | 2018-11-16 | 中国医学科学院生物医学工程研究所 | A kind of body temperature regulation method, apparatus, equipment and storage medium |
| CN111481335A (en) * | 2019-01-28 | 2020-08-04 | 深圳市科曼医疗设备有限公司 | Human body temperature adjusting method and device and sub-hypothermia treatment equipment |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102727338A (en) | Brain fixed-point sub-hypothermia control device | |
| US9844461B2 (en) | Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants | |
| US7241307B2 (en) | Method and apparatus for managing temperature in a patient | |
| CN1291875A (en) | System and method for heat control of living body | |
| CN202313904U (en) | Automatic temperature adjusting ice cap | |
| TW201117787A (en) | Tissue cooling device | |
| CN103142217A (en) | Electronic body temperature monitor | |
| CN101721273A (en) | Miniature electronic temperature-decreasing ice belt capable of being worn on heads | |
| CN202637240U (en) | Cold circulating type human body cooling device | |
| CN206007443U (en) | A kind of new freeze therapy unit | |
| CN100438839C (en) | Jet impulse type brain refrigerating device | |
| CN104288896B (en) | A kind of cranium brain perfusion cooling carrying case | |
| CN204170280U (en) | A kind of cranium brain perfusion cooling carrying case | |
| CN1088574C (en) | Method and apparatus for local temp. reducing of brain circulation system | |
| CN219878438U (en) | Emergency clinical equipment | |
| CN208852153U (en) | Infusion alarm | |
| CN2251987Y (en) | Local cooling instrument for cerebral circulating system | |
| CN2332389Y (en) | Temp controlled first aid cap | |
| CN2850587Y (en) | Medical cooler for human body | |
| CN202569174U (en) | Thermotherapy and chemotherapy instrument for bladder irrigation | |
| CN217854018U (en) | Blood cooling device | |
| CN217660392U (en) | Medical ice cap capable of being cooled intelligently according to target body temperature | |
| CN205094761U (en) | Medical sleeping bag | |
| CN212650869U (en) | Intelligent hemostasis device for bleeding during cesarean section | |
| CN116172687B (en) | Negative pressure regulation and control type cryotherapy system and control method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20121017 |