CN1772168A - Compound sterilizing aloe emulsion and its prepn and application - Google Patents
Compound sterilizing aloe emulsion and its prepn and application Download PDFInfo
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- CN1772168A CN1772168A CN 200410068055 CN200410068055A CN1772168A CN 1772168 A CN1772168 A CN 1772168A CN 200410068055 CN200410068055 CN 200410068055 CN 200410068055 A CN200410068055 A CN 200410068055A CN 1772168 A CN1772168 A CN 1772168A
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- aloe
- zinc oxide
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- chlorhexidine acetate
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Abstract
The present invention relates to one kind of medicine composition applied in sterilizing human skin, mucous membrane and wound, and features that the medicine composition has the ingredients of natural aloe extract, chlorhexidine acetate and zinc oxide. Specifically, the medicine composition consists of aloe powder prepared with aloe leaf through spray drying or freeze drying in 0.5-6.0 %, chlorhexidine acetate in 0.01-0.2 % and zinc oxide in 1-10 % as well as excipient in the rest amount. The present invention also relates to the preparation process of the medicine composition as well as the application of the medicine composition in sterilizing human skin, mucous membrane and wound.
Description
Technical field
The present invention relates to contain aloetic human body skin, mucosa or the wound disinfectant Pharmaceutical composition of being applied to, and its production and application.
Technical background
Enhancing with social hygiene's health care consciousness, disinfecting of human body skin, mucosa and various wounds just receives increasingly extensive concern, a large amount of sterile products inputs are used, but traditional chemical disinfection method all can cause in various degree injury to human body skin, and life-time service can cause chapped skin, pruritus or coarse; Simultaneously, long-term a large amount of chemosterilant that uses also can produce microorganism drug resistance problem.The present technique field is needed badly and is adopted advanced Pharmaceutical composition, with effectively, harmlessly to human body skin, mucosa or wound disinfection.
The present invention selects the main component of chlorhexidine acetate as sterilization for use, it has, and disinfective action is good, with low cost, stable in properties, to skin, mucosa nonirritant, general few advantage such as allergic phenomena that occurs.The present invention simultaneously selects for use metallic zinc as auxiliary antibacterial components, to overcome the issuable microorganism drug resistance of life-time service chemosterilant problem.By remedying disinfectant to the issuable injury of human body skin, mucosa or wound, the present invention selects the helper component of aloe extract as skin-protection and health-care for use, Aloe is traditional medical material of motherland's medical science, in the world, Aloe just has been more common in report to the health-care effect of skin since the eighties.The present invention selects above-mentioned three kinds of characteristic components for use, with reach preparation long-acting, safely, the purpose of the human body sterile products that has no side effect.
Beneficial effect
The present invention has broken the technical monopoly of imported product in this field, filled up domestic blank, the development of product of the present invention helps the raising of the whole research and development technology of national natural plants, and can provide novel effectively product and method for human body skin, mucosa or wound sterilization.
Summary of the invention
An object of the present invention is to provide novel, be applied to human body skin, mucosa or wound disinfectant Pharmaceutical composition, its characteristic component is aloe extract, chlorhexidine acetate and zinc oxide.
A further object of the present invention provides the preparation method of described Pharmaceutical composition.
Another object of the present invention provides described Pharmaceutical composition in the application of preparation to human body skin, mucosa or wound disinfectant medicine.
The objective of the invention is to implement: a kind of Pharmaceutical composition by following method, it is by the Aloe dry powder (mesophyll or Quan Yejing spraying or lyophilization make) of 0.5-6.0% (W/V), the chlorhexidine acetate of 0.01-0.2% (W/V), the zinc oxide of 1-10% (w/V) and the excipient of surplus are formed.
Described Pharmaceutical composition is the Emulsion form.PH value is 6.5-7.5.
Described excipient is selected routinely by those skilled in the art person.In an embodiment preferred, described excipient is materials such as vaseline, octadecanol, liquid paraffin, dodecyl sulfur sodium (SDS), glycerol, sterile distilled water.
Embodiment
Below in conjunction with specific embodiment the present invention is done further elaboration.
Embodiment 1:
Preparation contains 0.5% (W/V) Aloe dry powder (mesophyll is spray-dried to be made), 0.01% (W/V) chlorhexidine acetate, the described Pharmaceutical composition of 1% (W/V) zinc oxide.
1. take by weighing 4g octadecanol, 5g white vaseline, 4g liquid paraffin, molten even back insulation is standby.
2. take by weighing the 1g dry zinc oxide powder, put in the mortar, add the 10mL sterile distilled water, grind and make even suspension.
3. take by weighing commercially available 200: 1 Aloe mesophyll of 0.5g spray drying powder, commercially available 98% chlorhexidine acetate of 0.01mL, 1g dodecyl sulfur sodium (SDS), be dissolved in the 80mL sterile distilled water, stir and make abundant dissolving.
3. put in the emulsator above-mentioned, adds above-mentioned 1., 2. item, obtain white Emulsion after the emulsifying.
Embodiment 2:
Preparation contains 1.5% (W/V) Aloe dry powder (mesophyll is spray-dried to be made), 0.05% (W/V) chlorhexidine acetate, the described Pharmaceutical composition of 5% (W/V) zinc oxide.
1. take by weighing 3g octadecanol, 4g white vaseline, 3g liquid paraffin, molten even back insulation is standby.
2. take by weighing the 5g dry zinc oxide powder, put in the mortar, add the 10mL sterile distilled water, grind and make even suspension.
3. take by weighing commercially available 200: 1 Aloe mesophyll of 1.5g spray drying powder, commercially available 98% chlorhexidine acetate of 0.05mL, 1g dodecyl sulfur sodium (SDS), 5mL glycerol, be dissolved in the 80mL sterile distilled water, stir and make abundant dissolving.
3. put in the emulsator above-mentioned, adds above-mentioned 1., 2. item, obtain white Emulsion after the emulsifying.
Embodiment 3:
The preparation contain 2.0% (W/V) Aloe dry powder (mesophyll obtained by freeze drying), 0.05% (W/V) chlorhexidine acetate, 5% (W/V) Yangization ? described Pharmaceutical composition.
1. take by weighing 2g octadecanol, 3g white vaseline, 2g liquid paraffin, molten even back insulation is standby.
2. take by weighing the 5g dry zinc oxide powder, put in the mortar, add the 10mL sterile distilled water, grind and make even suspension.
3. take by weighing commercially available 200: 1 Aloe mesophyll of 2.0g lyophilized powder, commercially available 98% chlorhexidine acetate of 0.05mL, 1.2g dodecyl sulfur sodium (SDS), be dissolved in the 80mL sterile distilled water, stir and make abundant dissolving.
3. put in the emulsator above-mentioned, adds above-mentioned 1., 2. item, obtain white Emulsion after the emulsifying.
Embodiment 4:
Preparation contains 3.0% (W/V) Aloe dry powder (leaf is spray-dried entirely makes), 0.10% (W/V) chlorhexidine acetate, the described Pharmaceutical composition of 7% (W/V) zinc oxide.
1. take by weighing 4g octadecanol, 5g white vaseline, 3g liquid paraffin, molten even back insulation is standby.
2. take by weighing the 7g dry zinc oxide powder, put in the mortar, add the 10mL sterile distilled water, grind and make even suspension.
3. take by weighing commercially available 100: 1 aloe full leaf spray drying powders of 3.0g, commercially available 98% chlorhexidine acetate of 0.05mL, 1g dodecyl sulfur sodium (SDS), 6mL glycerol, be dissolved in the 80mL sterile distilled water, stir and make abundant dissolving.
3. put in the emulsator above-mentioned, adds above-mentioned 1., 2. item, obtain white Emulsion after the emulsifying.
Embodiment 5:
Preparation contains 4.0% (W/V) Aloe dry powder (mesophyll is spray-dried to be made), 0.15% (W/V) chlorhexidine acetate, the described Pharmaceutical composition of 8% (W/V) zinc oxide.
1. take by weighing 2g octadecanol, 3g white vaseline, 2g liquid paraffin, molten even back insulation is standby.
2. take by weighing the 8g dry zinc oxide powder, put in the mortar, add the 10mL sterile distilled water, grind and make even suspension.
3. take by weighing commercially available 200: 1 Aloe mesophyll of 4.0g spray drying powder, commercially available 98% chlorhexidine acetate of 0.15mL, 1g dodecyl sulfur sodium (SDS), be dissolved in the 80mL sterile distilled water, stir and make abundant dissolving.
3. put in the emulsator above-mentioned, adds above-mentioned 1., 2. item, obtain white Emulsion after the emulsifying.
Embodiment 6:
Preparation contains 6.0% (W/V) Aloe dry powder (full leaf obtained by freeze drying), 0.2% (W/V) chlorhexidine acetate, the described Pharmaceutical composition of 10% (W/V) zinc oxide.
1. take by weighing 4g octadecanol, 3g white vaseline, 3g liquid paraffin, molten even back insulation is standby.
2. take by weighing the 10g dry zinc oxide powder, put in the mortar, add the 10mL sterile distilled water, grind and make even suspension.
3. take by weighing commercially available 100: 1 aloe full leaf lyophilized powders of 6.0g, commercially available 98% chlorhexidine acetate of 0.2mL, 1g dodecyl sulfur sodium (SDS), be dissolved in the 80mL sterile distilled water, stir and make abundant dissolving.
3. put in the emulsator above-mentioned, adds above-mentioned 1., 2. item, obtain white Emulsion after the emulsifying.
Claims (4)
1. one kind is applied to human body skin, mucosa or wound disinfectant Pharmaceutical composition, its characteristic component is aloe extract, chlorhexidine acetate and zinc oxide, it is by the Aloe dry powder (mesophyll or Quan Yejing spraying or lyophilization make) of 0.5-6.0% (W/V), the chlorhexidine acetate of 0.01-0.2% (W/V), the zinc oxide of 1-10% (W/V) and the excipient of surplus are formed.
2. Pharmaceutical composition according to claim 1 prepares like this:
1. take by weighing an amount of oil phase excipient, molten even back insulation is standby.
2. take by weighing the zinc oxide of 1-10%, standby after the even matter.
3. take by weighing the Aloe dry powder (mesophyll or Quan Yejing spraying or lyophilization make) of 0.5-6.0% (W/V), the chlorhexidine acetate of 0.01-0.2% (W/V), be dissolved in the water excipient and sterile distilled water of surplus, stir and make abundant dissolving.
3. put in the emulsator above-mentioned, adds above-mentioned 1., 2. item, obtain white Emulsion after the emulsifying.
3. according to claim 1,2 described Pharmaceutical compositions, be the Emulsion form.PH value is 6.5-7.5.
4. be applied to the application of human body skin, mucosa or wound disinfectant medicine in preparation as the described Pharmaceutical composition of the arbitrary claim of claim 1-3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410068055 CN1772168A (en) | 2004-11-11 | 2004-11-11 | Compound sterilizing aloe emulsion and its prepn and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410068055 CN1772168A (en) | 2004-11-11 | 2004-11-11 | Compound sterilizing aloe emulsion and its prepn and application |
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| Publication Number | Publication Date |
|---|---|
| CN1772168A true CN1772168A (en) | 2006-05-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410068055 Pending CN1772168A (en) | 2004-11-11 | 2004-11-11 | Compound sterilizing aloe emulsion and its prepn and application |
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| CN (1) | CN1772168A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101869449A (en) * | 2010-06-29 | 2010-10-27 | 大连欧派科技有限公司 | Wet tissue special for commerce |
| CN101912517A (en) * | 2009-08-17 | 2010-12-15 | 黄汉贤 | Spray and gauze & ointment for preventing and curing bedsore and eczema |
| CN111956728A (en) * | 2020-07-15 | 2020-11-20 | 湖北华冠中科生物药业有限公司 | Alkalescent skin mucosa cleaning disinfectant and preparation method thereof |
-
2004
- 2004-11-11 CN CN 200410068055 patent/CN1772168A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101912517A (en) * | 2009-08-17 | 2010-12-15 | 黄汉贤 | Spray and gauze & ointment for preventing and curing bedsore and eczema |
| CN101912517B (en) * | 2009-08-17 | 2013-01-30 | 黄汉贤 | Spray and gauze & ointment for preventing and curing bedsore and eczema |
| CN101869449A (en) * | 2010-06-29 | 2010-10-27 | 大连欧派科技有限公司 | Wet tissue special for commerce |
| CN111956728A (en) * | 2020-07-15 | 2020-11-20 | 湖北华冠中科生物药业有限公司 | Alkalescent skin mucosa cleaning disinfectant and preparation method thereof |
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