CN1762478A - Nebula removing pills - Google Patents

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CN1762478A
CN1762478A CNA2005100128627A CN200510012862A CN1762478A CN 1762478 A CN1762478 A CN 1762478A CN A2005100128627 A CNA2005100128627 A CN A2005100128627A CN 200510012862 A CN200510012862 A CN 200510012862A CN 1762478 A CN1762478 A CN 1762478A
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radix
root
fructus
zijing
selenium
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CN1310667C (en
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李广中
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Abstract

The invention relates to a nebula removing pill which comprises the following components (by weight proportions): alkanna tinctoria, mother-of-pearl, abalone shell, wolferry fruit, motherwort fruit, plantain seeds, dodder seed, cherokee rose, mulberry seeds, raspberry, bitter cardamon, schisandra fruit, dragon's bone, Os Sepiae, broomrape, prepared rhizome of rehmannia, wild chrysanthemum flower, prepared rhizome of rehmannia, pulp of dogwood fruit, prepared fleece flower root, Bupleurum root, asparagus root, ophiopogon root, grassleaved sweetflag rhizome, polygala root, ledebouriella root, bat's feces, root bark of tree peony, oriental water plantain rhizome, poria with hostwood, astragalus root, pilose asiabell root, Chinese angelica root, Ligusticum wallichii, anemarrhena rhizome, corktree bark, banksia rose, Dendrobium nobile, spatholobus stem, licorice root 4-6, asarum herb 2-4.

Description

Nebula removing pills
Technical field
The present invention relates to a kind of nebula removing pills that adopts the animal eyes preparation.
Technical background
In today of scientific and technical high speed development, bathomorphic research slowly not before, we think that key is to be that etiology is undecided, and are agnogenio, are difficult to execute and control.Emphasis is out of joint on research method.Etiology and pathogenesis is to diagnose originally the root of the rule of treatment, the source of determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs.
Western medicine and domestic doctor trained in Western medicine all have been limited in etiology on the genetic problem, are multifactorial inheritances and high myopia is autosomal recessive inheritance, AR as simple myopia, and " the genetic control opinion of myopia " stops the development of myopia studies.Academic state rests on the experimental study stage always, although understanding deepens continuously, achievement is very little, still learning concept is smudgy, at present large hospital can only the mirror wildcarding correcting vision or operation rescue.For the student, put on the PD that near-sighted glasses are also lost control of the student, constantly increase with grade, the near-sighted number of degrees also continue to increase, and for the student, operation is rescued and is not indication, and it is still remote that prospect is captured in the myopia treatment.
And,, not only to see quality of medical care for the discovery and the invention of new drug at present at China student oculopathy-bathomorphic medical care problem, also to see the crowd's of being medically treated economic capability.China is developing country at present still, and the people, wage-earners are big, and generally income is few, is characteristics simply having adequate food and clothing, makes the receptible new drug of the numerous common people must consider the product that cost is low, quality is high, just the medicine that numerous students are received treatment comprehensively.
Theory of Chinese medical science is the guide of holistic medicine, and whole the sight is that the traditional Chinese medical science is seen the marrow that the people knows the theory of disease, still thinks outer because of main from ancient times to the present, and is interior because mend, congenital defect, and mend the day after tomorrow.According to textual criticism, China's myopia is documented in " Records of the Historian " before 2000 to be had: " looking as hoping sheep " record.In 610 years Christian eras, in Sui's Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases order sick duke or princess under an emperor " there be note: " order can not hypermetropia, the impairment caused by overstrain internal organs is dirty, deficiency of liver-QI ".625 years Christian eras Tang's Sun Simiao " preventing and treating 16 of oculopathy " in have 10 with myopia relevant.End of the Ming Dynasty Fu Renyu " Precious Book of Ophthalmology " is pointed out: " Liver Channel deficiency, kidney channel disease ", " possess generate myopia ", " watching for a long time is hindered eyeball and become myopia " or the like illustrate that all " near-sighted etiology and pathogenesis " is due to environmental effect and the congenital defect cross interference.The physique constitution of students in 26 years of China, healthy investigation now found: constitutional myopia all betides child and teen-age growth and development stage, seldom morbidity behind the adult.This is relevant with the physiological characteristics of human body ocular structure emmetropization tendency fully, and constitutional myopia has 62.5% not have near-sighted family history; Have only 37.5% near-sighted family history is arranged; The heterozygote morbidity accounts for 17.5%; The high myopia number accounts for the 1-5% of total population number.Therefore we carry out having set up " environmental genomics " in the deep structure research of " environment and gene ", " gene and environment " under the overall situation influence of human genome, negate that " absolute genetic control opinion " judges that Chinese student's myopia is " can control the crowd " fully.
Summary of the invention
Technical problem to be solved by this invention is to propose ZIJING application in preparation treatment myopia preparation as single new drug and other drug matching, thereby provides that a kind of therapeutic effect is good, medical expense is low, the extensive bathomorphic preparation of the treatment of popularization and application.
The technical scheme that the present invention proposes is: the application-preparation nebula removing pills in preparation treatment myopia preparation as Chinese medicine single new drug ZIJING and following drug matching, and the pill that adopts following ratio of weight and number component to make:
Each each 9-11 Radix Glycyrrhizae 4-6 Herba Asari 2-4 of 14-16 Os Draconis Endoconcha Sepiae Herba Cistanches Radix Rehmanniae Preparata Flos Chrysanthemi medicines rehmannia rhizome, cornus officinalis Radix Polygoni Multiflori Preparata Radix Bupleuri white peony root Radix Asparagi Radix Ophiopogonis Rhizoma Acori Graminei Radix Polygalae Radix Saposhnikoviae Faeces Vespertilionis Cortex Moutan Rhizoma Alismatis Poria cum Radix Pini Radix Astragali Radix Codonopsis Radix Angelicae Sinensis Rhizoma Chuanxiong Rhizoma Anemarrhenae Cortex Phellodendri Radix Aucklandiae (Radix Vladimiriae) Herba Dendrobii Caulis Spatholobi of ZIJING 29-31 Concha Margaritifera 29-31 Concha Haliotidis 19-21 Fructus Lycii Fructus Leonuri Semen Plantaginis Semen Cuscutae Fructus Rosae Laevigatae Fructus Mori Fructus Rubi Fructus Alpiniae Oxyphyllae Fructus Schisandrae Chinensis.
According to Chinese medicine title tradition nomenclature, use the place of production and medicinal part to the new drug standardize naming, the Ziyang buphthalmos is called for short: ZIJING.The place of production: ground such as Ziyang, Shaanxi, Shitai County, Anhui, enshi.
ZIJING is a vertebrates, the bright whole eyeball of the healthy cattle of Bovidae, Ziyang, or horse, donkey, the healthy bright whole eyeball of mule.
ZIJING is spherical or irregular spheroidal, diameter 2-3 centimetre, weight 60-80g, color aquatic foods, complete, sixth has semicircle born of the same parents' eyelid, fissura palpebrae, eyelashes before the eyeball, and black eyeball, Pupil god, tunica albuginea are arranged in the palpebral fissure, and back sixth body wall is softer, pliable and tough, surface is creamy white, smooth flexible, feeble QI is had a strong smell, and saline taste is arranged.
The ZIJING four seasons all can gather, and with fresh and alive eyeball extraction, the flush away bloodstain removes clean lipid foreign material on every side, wraps up, dries in the shade the freezing antistaling storing with Medulla Junci behind the salting when slaughtering an ox.Avoid with fiery baking, Exposure to Sunlight, wind in case break rottenly, the bright complete crack-free person of color is a good merchantable brand.Belong to ophthalmic remedy.
The ZIJING meridian distribution of property and flavor: sweet flat, salty, be slightly cold; The heart, liver,kidney,spleen.
ZIJING pharmic function: have tonification visceral-qi, nourishing blood and nutrient QI, suppressing the hyperactive liver to relieve the wind syndrome, liver heat removing and eyesight improving, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, myopia change disease, sensible recovering lost eyesight.
ZIJING pharmaceutical formulation of the present invention:
1. tablet: should meet " the regulation of two appendix 1A of Chinese pharmacopoeia version in 2000
2. sugar pill: should meet " the regulation of two appendix 1H of Chinese pharmacopoeia version in 2000
3. Eye ointments: should meet " the regulation of two appendix 1G of Chinese pharmacopoeia version in 2000
4. eye drop: should meet " the regulation of two appendix 1J of Chinese pharmacopoeia version in 2000
5. powder: should meet " the regulation of two appendix 1P of Chinese pharmacopoeia version in 2000
6. capsule: should meet " the regulation of two appendix 1E of Chinese pharmacopoeia version in 2000
[scope of application]: the main flavor medicine of filling a prescription on the myopia when all kinds of each phase myopia, developmental ophthalmocace, hypermetropia, astigmatism, stravismus, amblyopia, eyestrain, ocular injury, myopia complication, optic atrophy, non-suppurative keratitis, red film cyclitis, fluctuation body muddiness, central retinochoroiditis, ZIJING.
Good effect of the present invention can obtain explanation by following determination data and clinical conclusion.
One, content assaying method:
1. sensing equipment:
(1) SB-01 Atomic Absorption Spectrometer AAS.SOLAAR-M6 Tbermo jarrellashco. (USA)
(2) SB-23 chromatograph of liquid HPLC.LC-10A shimadzn (JAPAN)
(3) trade of SB-24 inductively coupled plasma boils instrument ICP-MSX7 Tbermo jarrellashco. (USA)
(4) SB-31 Hitachi 8350 automatic amino acid analyzers
2. bioassay standard
(1)GB/T5009.13-2003 (2)GB/T5009.14-2003 (3)GB/T5009.82-2003
(4)GB/T5009.84-2003 (5)GB/T5009.86-2003 (6)GB/T5009.90-2003
(7)GB/T5009.91-2003 (8)GB/T5009.92-2003 (9)GB/T5009.93-2003
(10)GB/T5009.123-2003 (11)GB/T5009.124-2003
3. measurement result
This product is Ziyang, a Shaanxi buphthalmos (abbreviation-ZIJING), and the bright product single of ZIJING new drug China Metrology Accreditation testing result is as follows:
(1) trace element:
1) calcium (Ca): 269.5mg/kg 2) ferrum (Fe): 45.8mg/kg 3) copper (Cu): 3.60mg/kg
4) chromium (Cr): 1.30mg/kg 5) manganese (Mn):<0.002mg/kg 6) magnesium (Mg): 67.1mg/kg
7) sodium (Na): 7.56 * 10mg/kg 8) potassium (K): 391.9mg/kg 9) zinc (Zn): 5.81mg/kg
10) selenium (Se) 0.020mg/kg
(2) aminoacid:
1) aspartic acid (Asn) 1.12g/100g 2) threonine (Thr) 0.14g/100g
3) serine (Ser) 0.65g/100g 4) glutamic acid (Glu) 1.80g/100g
5) glycine (Gly) 3.24g/100g 6) alanine (Ala) 1.24g/100g
7) valine (Val) 0.41g/100g 8) methionine (Met) 0.19g/100g
9) isoleucine (Ile) 0.39g/100g 10) leucine (Leu) 0.73g/100g
11) tyrosine (Tyr) 0.31g/100g 12) phenylalanine (Phe) 0.52g/100g
13) lysine (Lys) 0.72g/100g 14) histidine (His) 0.20g/100g
15) arginine (Arg) 1.34g/100g 16) proline (Pro) 1.75g/100g
17) tryptophan (Trp) 0.19g/100g 18) cystine (Cys) 0.16g/100g
19) ammonia (An) 0.22g/100g 20) aminoacid summation 15.59g/100g
(3) vitamin
1) vitamin A 1.85 * 10mg/100g 2) vitamin B1 2.16 * 10mg/100g
3) vitamin B 27.13 * 10mg/100g 4) vitamin B12 0.84 μ g/100g
5) vitamin E 1.68 * 10mg/100g
Two, provide 1, Beijing spectrum Buddhist nun physico-chemical analysis test center " survey report "
Detect: ZIJING
The bright full buphthalmos ball in Ziyang, Shaanxi
Sample state: solid-state
Temperature: 25 ℃
Inspection item:
Calcium (Ca): 269.5mg/kg ferrum (Fe): 45.8mg/kg copper (Cu): 3.60mg/kg
Chromium (Cr): 1.30mg/kg manganese (Mn):<0.002mg/kg sodium (Na): 7.56 * 10 3Mg/kg
Potassium (K): 391.9mg/kg zinc (Zn): 5.81mg/kg magnesium (Mg): 67.1mg/kg
Selenium (Se): 0.020mg/kg vitamin A: 1.85 * 10 -2Mg/100g
Vitamin B 1: 2.16 * 10 -2The mg/100g vitamin B 2: 7.13 * 10 -2Mg/100g
Vitamin B 12: 0.84 μ g/100g vitamin C: do not detect
Vitamin E: 1.68 * 10 -1Mg/100g.Aspartic acid: 1.12g/100g threonine: 0.41g/100g
Serine: 0.65g/100g glutamic acid: 1.80g/100g glycine: 3.24g/100g
Alanine: 1.24g/100g valine: 0.41g/100g methionine: 0.19g/100g
Isoleucine: 0.39g/100g leucine: 0.73g/100g tyrosine: 0.31g/100g
Phenylalanine: 0.52g/100g lysine: 0.72g/100g ammonia: 0.22g/100g
Histidine: 0.20g/100g arginine: 1.34g/100g proline: 1.75g/100g
Tryptophan: 0.19g/100g cystine: 0.16g/100g aminoacid summation: 15.59g/100g
Three, provide 2, Beijing spectrum Buddhist nun physico-chemical analysis test center " survey report "
Detect: bright buphthalmos ball
Inspection item:
Calcium (Ca) 120.6 μ g/g zinc (Zn) 4.3 μ g/g copper (Cu) 1.0 μ g/g
Ferrum (Fe) 24.4 μ g/g potassium (K) 717.8 μ g/g magnesium (Mg) 46.5 μ g/g
Sodium (Na) 2337.2 μ g/g manganese (Mn) 0.45 μ g/g nickel (Ni) 5.9 μ g/g
Chromium (Cr) 1.9 μ g/g
Four, the inorganic constituents of ZIJING--trace element is treated bathomorphic physiology and pharmacological action analysis
1. the pharmacology analysis of trace element:
Chinese medicine ingredients and the drug effect analysis drug effect that integrates with, this is a kind of with molecular medicine, physiology, pathology, a cytohistologic innovation.Trace element is the material base of the human body cell function of macroscopical relatively macroelement, though trace element only is 0.05% of a human body weight, but it is in close relations with the physiological function of human body, the experiment proved that, the generation of child, the juvenile myopia of research growth and development stage, to develop, lapse to process all closely related with trace element, shortage as selenium, zinc, chromium, copper, manganese, calcium is relevant, so in control, must be noted that the ingredient of trace element, be that example is analyzed as follows apparently higher than the selenium in other place of production buphthalmos with trace element in the ZIJING:
(1) selenium: be to promote the multiple metabolic activity material base of ophthalmic, becoming human body to include the selenium total amount is 14-21mg, more with liver, pancreas, kidney content.Selenium is indispensable physiological function material in the human eye: selenium mainly has two kinds with the organic selenium compounds form in human body: the one, contain selenoamino acid, and another kind is a selenoprotein.Selenizing aminoacid mainly is selenizing cystine (Se-Cys) and selenomethionine (Se-Met); Most importantly glutathion peroxidase (HSH-Px) in the selenoprotein.Selenium is in the protein with two kinds of forms, a kind of disassociation factor, and another kind is the specific site performance.
1., the basic substance of selenium " visual acuity ": participating in the function of photoreceptor in the eye directly, participate in the conversion process of energy that photon conversion becomes the signal of telecommunication, thereby guarantee the vision normal function, is the basic substance of visual acuity.Hawkeye " visual acuity " higher position is because the selenium content height, bears in the eyes retina to contain selenium 700-800 microgram, and the normal eye contains 7 micrograms, and myopia takes place, develops, lapses to that retina selenium amount constantly reduces in the process, consequently causes blind.Closely related through laboratory report prompting myopia pathology and trace element.
2., selenium promotes the basic substance of the multiple metabolic activity of ophthalmic: selenocysteine is that the essential composition, particularly glutathion peroxidase (GSH-Px) of plurality of enzymes prothetic group is the destruction of the peroxidating ammonia pair cell that oxidizing process produces in the antagonist.Be to guarantee the important material of the normal operation of endocellular metabolism function.Selenium has obvious activation to the alpha Ketoglutarate dehydrogenase system.Promote the biosynthesis of coenzyme A, ubiquinone, so relevant with the electron transport of tricarboxylic acid cycle and respiratory chain.Tricarboxylic acid cycle is the substance metabolism hinge, is the last shared pathway of sugar, fat fat, the decomposition of aminoacid three major nutrient, is that acquisition maximum stages of energy are decomposed in three big material ammonifications, and the conduction function that directly affects one's power of vision has very important physiology of eye effect.
3., selenium has the anti-cell aging, the degenerative lesion that stops ocular structure: free radical is the one of the main reasons of human cell's aging, its main mechanism is lipid peroxidation, promptly in the presence of oxygen, free radical is an inducing agent, can bring out the inside and outside multiple biochemical component peroxidating of cell, makes the damage of cell membrane, cell interior 26S Proteasome Structure and Function, cause physiology, biochemical reaction disorder, show degenerative lesion.Therefore, allly free radical or polyphenoils can be eliminated, anti-senescence function can be stoped.Selenium by antioxidation and removing free radical, reduces or postpones the formation of lipofuscin just, thereby reaches the order ground of anti-cell aging and apoptosis.In ocular structure, glutathion peroxidase (GSH-P x) be the important enzyme of anti-peroxidation, its major function is the formation that stops peroxide and free radical, selenium then is GSH-P xImportant component part, 4 selenium atoms are arranged in each enzyme molecule.Contain selenic GSH-P xHave extremely strong antioxidation, can make peroxide (ROOH) or H 2O 2Be reduced into nontoxic alcohol and water, just because of containing selenic GSH-P xCan Cuiization H 2O 2Reduction reduces active oxygen, just makes the chance of oxidation unsaturated fatty acid and lipid reduce, and the generation of free radical just can be inexcessive, keeps the normal vigorous physiological metabolism of cell, reaches the purpose of anti-cell aging.
4., selenium in ocular structure to the histiocyte repair: selenium is the main component of peptide and enzyme in the metabolism, the effect with oxidation and removing free radicals, selenic antioxidative functional mass is glutathion peroxidase (GSH-P x) main component; selenocysteine provides the necessary group in active center for this enzyme; the important component of glutathion peroxidase; catalytic reduction type glutathion becomes oxidized form of glutathione; utilize glutathion (GSH) to make virose peroxide be reduced to harmless hydroxy compounds; make oxide decompose, remove free radical, and protection membrane structure and function stop degenerative lesion.To stoping bathomorphic progress, promote reparation to play an important role, repair the molecule damage location.Selenium is the normal composition of eye muscle; can make eye muscle meat contraction convulsion and atrophy when lacking selenium, myocyte's compactness becomes, and lipid increases; calcinosis; cause into the muscular strength regression, selenium can quicken the structure cytothesis of regression, and the ciliary muscle cell is had protective effect; obviously suppress the non-enzymatic lipid peroxidation of eye muscle; stablize denatured areas inner cell and subcellular fraction film and alleviate muscle injury, dwindle the degenerating cell scope, therefore reach ocular tissue's cell, reach the purpose that stops regression and play reparation the regression disease.
5., selenic antiinflammatory action: selenium is that antioxidant also is an antiinflammatory, selenium GP particularly in antioxidation process xLipid hydroperoxide and phospholipid hydrogen peroxide can be reduced, thereby gathering of free radical and active oxygen can be reduced.In Cycloxygenase and lipoxygenase pathway, GP xCan reduce the intermediate product of hydroxide, thus the prostacyclin that inhibition causes inflammation and the generation of leukotriene.GP in addition xCan also regulate respiratory burst by the generation of removing hydrogen peroxide and minimizing superoxides.Disease with oxidation reaction increase and inflammation-related all is subjected to the influence of selenium level.Experimental results show that: utilize bacterium colony in two bacteria culture medias (staphylococcus aureus and escherichia coli) to splash into to contain in the high natural tear of selenium the purification thing promptly be pure " lysozyme " drip to bacterium colony after 3 hours the bacterium colony dissolving disappear.In current experiment, find: purify in human tears liquid a kind of " lysozyme "; composition promptly is the higher solution of glutathion peroxidase content; relatively form is less for lysozyme in the tear and other lysozyme; very active; can be adsorbed onto in the crack of bacteria cell wall, " the enzyme pincers " of " lysozyme " directly vise the oxygen of two sugar rings in the antibacterial glycoprotein, thereby reduce bond energy; sugared key is broken very soon, and dissolving reaches the antiinflammatory purpose so antibacterial is dead.Glutathion peroxidase not only has anti-oxidation characteristics, also has the effect of anti-inflammation.
6., selenium and immunologic function: no matter from epidemiological study, or zoopery has proved that all selenium all has important relation to bathomorphic generation, development.Selenium is to biological fluid Immune Effects, also paid more and more attention.This has confirmed to have become indispensable element at the early stage selenium that human embryos are grown; it is except the composition as GSH-Px; outside removing free radical, protection cell membrane, nucleic acid, proteinic normal configuration and function; toxicity that can also antagonism heavy metal (hydrargyrum, lead, arsenic, cadmium, thallium) has Detoxication.Verify bright factually: utilize human peripheral lymphocyte and 10 -9~10 -6The selenium of M is cultivated together, finds that selenium can promote the generation of interferon, and in the external activity that can increase the r-interferon, strengthens the cytotoxicity of NK cells of human beings.We also find in the presence of sodium selenite, and the inductive mice spleen cell secretion of ConA 1L-2 increased activity highly significant is 2~3 times of matched group; Through the selenium pretreatment can spontaneous secretion 1L-2 generation.The secretion 1L-1 that selenium can also significantly increase macrophage is under the condition that LPS exists, and its activity of 1L-1 that adds sodium selenite is significantly higher than matched group under different diluting conditions.Human peripheral lymphocyte and mouse boosting cell PHA and ConA after the selenium pretreatment of low concentration induce the 1L-Z activity level obviously to raise; And find that concentration of sodium selenite is 3 * 10 -7During M, its facilitation is the strongest, and the 1L-2 activity level is 2 times of matched group.
Experimental results show that: selenium can also increase the secretion of immunoglobulin, leukocyte increasing is engulfed with sterilizing ability and is made the antigen of spleen adherent cell improve ability, though the effect of the no direct activation macrophage of sodium selenite itself, can not impel lymphocyte to produce macrophage activating factor (MAF) (MAF), but the synergistic activation macrophage is arranged and strengthen active anticancer with MAF, can remove low macrophage simultaneously lymphocytic inhibitory action.We find that selenium can activate peritoneal macrophage from the research that selenium is regulated the inductive cytotoxic cell of lymphocyte (LICC), the cell toxicant differentiation factor (CCDF) of its generation can with the activity of 1L-2 synergistic activation LICC; Also find simultaneously to use the internal energy activated macrophage of body and can promote the selenium dosage of its phagocytic function when experiment in vitro, not have the cytotoxic activity effect of significant short LICC, and the selenium of high dose has reversible inhibitory action to LICC.
NK cells of human beings is drawn as drawing a conclusion after active external influence and the Study on Mechanism thereof carrying out selenium:
1) concentration is the cytotoxic activity that the sodium selenite of 100-500ng/ml can obviously strengthen the NK cell;
2) imitate more height of target ratio, potentiation significantly;
3) selenium does not damage target cell membrane, does not see that activating PERIPHERAL BLOOD MONONUCLEAR CELL discharges more NK-cytotoxic factor (NKCF) yet.Think that selenium may be to promote both combinations by some structure that activates NK cell and target cell membrane surface, thereby strengthen the NK killing activity.Also observe selenium in addition and can enlarge the proliferation function of reorganization r-interferon (HnINF-r) the NK cell at body.Trace element has remarkable facilitation to immunity of organism.
Five, the analysis on trace of Chinese medicine:
Analysis on trace is to intert research project in each side such as medical material, process preparation, clinical practices.Past effective components of Chinese medicinal research biases toward Organic substance mostly, and less to the research of inorganic matter wherein.Since the eighties, along with people to the raising on the trace element effect understanding, the analysis on trace of Chinese medicine is also launched rapidly, mainly shows following several respects:
1. single medicinal material trace elements determination: find to contain in the composition macroelements such as various trace elements such as zinc, selenium, copper, chromium, manganese, calcium and sodium, potassium, magnesium during as the composition measurement of ZIJING, determine its status in treatment.How about the iron-holder of the Radix Polygoni Multiflori is measured the trace element that is higher than other, in the trace elements determination of Radix Ginseng, also finds to contain harmful substances such as harmful cadmium, antimony, bismuth, lead, therefore takes for a long time and will note appropriateness.
2. with the analysis on trace in the different places of production of a kind of Chinese medicine: as ZIJING must be that Ziyang buphthalmos content has therapeutic value, the treatment disease of can not being used as medicine that the content of other regional buphthalmos is extremely low.And for example the content of rubidium and manganese is the highest in the Rhizoma Gastrodiae, but the different place of production, contains the amount difference of trace element.Particularly rubidium, manganese, brill, lithium, molybdenum etc. think that this can be used as one of material base of estimating the Rhizoma Gastrodiae quality, hold concurrently and estimate the flavour of a drug quality.See the different places of production of ZIJING content elementary analysis table:
The different places of production bright buphthalmos ball micronutrient levels contrast table
Figure A20051001286200101
Annotate: area, Ziyang buphthalmos is apparently higher than the content of area, Shanghai buphthalmos, and the manganese that eye function plays the interference effect is lower than Shanghai, the medicine source is gathered plays suggesting effect for we study the myopia treatment.
3. with clinical relevant effect applied research: if any the human atomic absorption spectrography (AAS) content of zinc, copper, ferrum in 40 kinds of emmenagogues such as Radix Angelicae Sinensis is measured and to be shown: iron content height such as Radix Morindae Officinalis, Radix Angelicae Sinensis; Rhizoma Polygonatis etc. contain the zinc height; Cupric height such as Fructus Schisandrae Chinensis.Pointed out the Chinese medicine the kidney invigorating, nourished blood, invigorated blood circulation, in close relations between the material base of Qi-tonifying drug and zinc, copper, ferrum and the human endocrine function.
The analysis on trace of Chinese medicine different parts 4. of the same race: as body, head, the tail of Radix Angelicae Sinensis, clinical function difference, its trace element is also different.Human energy dispersion X-ray analysis method is arranged, has measured the multiple tenor in Radix Angelicae Sinensis, body, the tail respectively, find that calcium in Qin's Radix Angelicae Sinensis, copper, manganese content are the highest, for the 1.5-6.8 that returns body or Radix Angelicae Sinensis doubly; Potassium in the Radix Angelicae Sinensis, iron content are the highest, for the 1.5-2 that returns head or return body doubly.The river Radix Angelicae Sinensis is [33] like this also.
5. cultivation and wild: comprise the research of trace element between synthetic and the natural drug.As wild animal and handling animal, contained trace element there are differences between wild plant and the cultivated plant.Most elements content becomes the positive benefit with place of production elements in Soil content (particularly active part).So, can consider to improve artificial culture or artificial breeding's quality by the supply measure of trace element.
Six, the physiological and pharmacological function analysis in near-sighted human body of the vitamin in the ZIJING:
Vitamin is to keep the necessary class organic compound of human body normal activities, and its content is atomic in vivo, but plays an important role in processes such as the metabolism of body, growth, growth.Though their chemical constitution and character are not close, and common feature is arranged: 1. all with vitamin itself, or the form of the precursor compound (having another name called the quality of supporting one's family) that can be utilized by body is present in the natural food; 2. non-housing construction composition does not provide heat energy yet, but is undertaking special metabolic function; 3. generally can not synthesize in vivo, or synthetic quantity (vitamin D exception) very little, must provide or medicine replenishes by food; 4. human body only needs minute quantity to satisfy, but must not lack.Lack certain vitamin to a certain degree, can cause avitaminosis.Just show multivitamin in the occurrence and devlopment of myopia process and lack feature, the discovery of ZIJING ocular structure just needs the additional medicine of multivitamin in a large number.
Good effect of the present invention is conspicuous, ZIJING is through biochemical analysis, contain various trace element, several amino acids, protein, multienzyme, polypeptide, nucleotide, materials such as vitamin, trace element, vitamin, plain this three big element of amino acid nutrient, it is the material base of animal Ziyang the eye splice structure functional metabolism, it also is the material base that the essential treatment of myopia replenishes, the tissue metabolism that the product of this bioid factory of buphthalmos and active substance are participated in human eye directly, can mend visceral-qi, nourishing blood and nutrient QI, the spleen invigorating of nourishing heart, strong eye muscle, slow spasm, flat sweet flame-out, liver heat removing and eyesight improving, black expense is moved back, stasis of blood block removing is fallen, stop eye to stop degenerative lesion, refreshing light is eagle-eyed, and brilliance is sent out more at a distance, look hypermetropia closely freely, vision restoration as before.
Clinical practice: myopia is the disease based on deficiency syndrome, " deficiency syndrome should be treated by tonifying method ", the natural endowment deficiency, enrich blood the day after tomorrow, deficiency of both the liver and kidney, asthenia of essence and blood, when suitable liver and kidney tonifying, beneficial essence is enriched blood and is method of treatment;
Cross and use eyesight, overworked eyes causes declination of heart-YANG, or deficiency of liver-blood, controls suitable tranquilizing by nourishing the heart, or nourishing blood to suppress the hyperactive liver; Eating and drinking without temperance, impairing the spleen and stomach, insufficiency of vital energy and blood is controlled suitable invigorating the spleen and benefiting QI;
A little less than the deficiency of vital energy blood, blood fortune is unable, or qi depression to blood stasis, controls suitable benefiting vital QI and blood, blood circulation promoting and blood stasis dispelling.
In, the low myopia eye, often based on deficient syndrome, the treatment rule should be based on tonify deficiency; High myopic eye is this with void, but deteriorated case is numerous and disorderly, and deficiency complicated with excess is often arranged.Or show as principal contradiction with excess syndrome, by the principle of the traditional Chinese medical science " symptomatic treatment in acute condition ", " radical treatment in chronic case ", this moment should be based on timid heresy.As cooling blood for hemostasis, clearing away heat-damp and promoting diuresis, method of treatment such as blood circulation promoting and blood stasis dispelling.Certainly, when timid heresy, should expect deficiency in origin.Because of this cause of disease because of complexity, disease is various, should be principle with " radical treatment in chronic case " at ordinary times, the body resistance strengthening and constitution consolidating, liver and kidney tonifying, invigorating the spleen and benefiting QI is main, simultaneously, also be the treatment this disease therapy commonly used.
[clinical manifestation]: being clear, distant vision being blurred, the sight dimness, slow-witted order does not have god, inappetence, anorexia, monophagia, few food, emaciation and sallow complexion, myasthenia of limbs, weak after being ill, pale tongue with thin fur is white, thready and weak pulse.
[etiology and pathogenesis]: The spleen has the function to transport and transform nutrients, main the lucid yang sending up, insufficiency of the spleen then precise and tiny can not fail in liver, liver do not conserve, that irritability is on the decline, liver is insufficiency of the spleen is weak, deficiency of QI in middle-JIAO, retention of water-damp in the body, insufficiency of vital energy and blood.Asthenia of liver and spleen is an asthenia of essence and blood, and two orders lose supports.Refreshing light is loved little, and refreshing light is for the source deficiency, and brilliance can not reach with at a distance, so myopia is timid far away, axis oculi elongates, and it is prominent that eyeball becomes, the anterior chamber deepens, mydriasis, and light reflex is blunt, essence and blood can not be gone up honor, YANG-orifices failing to be nourished, the dreaminess so dizzy, dizzy, tinnitus, night are slept, asthenia of essence and blood, sering is not filled, thready pulse without strength then, the few tongue of red tongue.
[rule of treatment]: the block removing of liver and kidney tonifying benefit intensive culture blood suppressing the hyperactive liver to relieve the wind syndrome makes eye bright
[square medicine]: 42 flavor ZIJING ball YANSUTAI ZHUSHEYE, convalescent period eye muscle training
[prescription]: each each 10g Radix Glycyrrhizae 5g Herba Asari 3g of 15g Os Draconis Endoconcha Sepiae Herba Cistanches Radix Rehmanniae Preparata Flos Chrysanthemi medicines rehmannia rhizome, cornus officinalis Radix Polygoni Multiflori Preparata Radix Bupleuri white peony root Radix Asparagi Radix Ophiopogonis Rhizoma Acori Graminei Radix Polygalae Radix Saposhnikoviae Faeces Vespertilionis Cortex Moutan Rhizoma Alismatis Poria cum Radix Pini Radix Astragali Radix Codonopsis Radix Angelicae Sinensis Rhizoma Chuanxiong Rhizoma Anemarrhenae Cortex Phellodendri Radix Aucklandiae (Radix Vladimiriae) Herba Dendrobii Caulis Spatholobi of ZIJING 30g Concha Margaritifera 30g Concha Haliotidis 20g Fructus Lycii Fructus Leonuri Semen Plantaginis Semen Cuscutae Fructus Rosae Laevigatae Fructus Mori Fructus Rubi Fructus Alpiniae Oxyphyllae Fructus Schisandrae Chinensis
[method for making] grinds to the powder altogether, and banburying is a ball, the heavy 20g of ball, and day twice, one time one ball of clothes, one after each meal, eliminating cold for resuscitation water send down.
15 days one courses of treatment of YANSUTAI ZHUSHEYE 1ml * 0.6 * 2 district's injection are annotated in a cave in [adapted] (1) eye district
(2) eye muscle training
Nebula removing pill for curing myopia deficiency of both the liver and kidney type 120 routine observation of curative effect
Assertive evidence belongs to near-sighted deteriorated case, and cloud and mist moves fine, and cataract category disease is a difficult and complicated illness medically.After finding Chinese medicine single medicinal material ZIJING in 1985, behind pharmacology, toxicological experiment, be that the monarch drug formula and prescription accumulates clinical experience for many years to assertive evidence with the ZIJING.In the recent period in 2000 to calendar year 2001 stochastic sampling patient medical history 120 examples summarize and receive curative effect preferably, the present is reported as follows:
One clinical data
Stochastic sampling clinic case myopia deficiency of both the liver and kidney type 120 examples are established matched group and treatment and are organized two groups of observe the curative effect.Nebula removing pills is taken by observation group, and matched group is taken MINGMU DIHUANG TANG.Two groups of contrasts are added up, male's 38 examples among the 60 routine patients of observation group, women's 22 examples, 24 examples of course of disease 1-5,6-10 12 examples, 18 examples more than 10 years; Matched group 60 routine patients, 36 examples of course of disease 1-5,6-10 17 examples, 7 examples more than 10 years.
Two diagnostic criterias
Formulate according to State Administration of Traditional Chinese Medicine's formulation industry standard " traditional Chinese medical science disease diagnoses and treatment standard " with reference to " myopia " diagnostic criteria that Wang Fangrun writes:
1. examination of visual acuity: the normal distant vision of near vision<1.0
2. examination of refraction: retinoscopy under the cycloplegia, near-sighted diopter at least 〉=-0.25D
3. card class diagnostic criteria:
1. main symptom: being clear, distant vision being blurred, poor vision, black flower waves.
2. inferior card: inappetence, flavor is received not good, the sight dimness, slow-witted order does not have god, dizziness and tinnitus, soreness of the waist and knees, the cold physique fear is cold.
3. tongue arteries and veins: pale tongue with thin fur is white, deep,thready and forceless pulse
4. optical fundus: the browny strip of white formula, lamellar, block muddy in the refreshing cream of ophthalmic
5. etiology and pathogenesis, myopia for many years, liver-blood deficiency, deficiency of both the liver and kidney, look to lose to support then to look and become muddiness, deficiency of kidney-essence, brain inanition, asthenia of essence and blood, sering and do not fill as mosquito, asthenia of essence and blood, refreshing cream, essence and blood can not be gone up honor, so dizzy, dizzy, tinnitus.It is white that anterior chamber's intensification, mydriasis, YANG-orifices failing to be nourished, soreness of the waist and knees, deep,thready and forceless pulse, pale tongue with thin fur are elongated in the dreaminess of sleeping night, axis oculi, is the disease of deficiency of both the liver and kidney.Far, near vision all descends.
Three Therapeutic Method
The heavy 20g of observation group's nebula removing pills ball one time one ball day clothes 2 times, morning and evening one after each meal and the same usefulness of ZIJING FUMING YANTIE, two weeks were a course of treatment.Matched group adopts the MINGMU DIHUANG TANG plus-minus.
Four efficacy analysis
1. criterion of therapeutical effect
1. cure: rise to 1.0 through the treatment vision, observed through three months vision not the descender for curing.
2. take a turn for the better: risen the above person of 3 row for taking a turn for the better through the treatment vision.
3. invalid: through treatment vision rising less than 2 passerbys is invalid.
2. the result adds up
Two groups of controlled observation statistical tables
Group The example number Cure routine number % Routine number % takes a turn for the better Invalid routine number % Total effective routine %
Observation group's matched group 60 60 4520.0 2043.33 1220.0 610.0 35.0 3456.66 95 43.33
Conclusion: show by statistics, observe treatment and significant difference is arranged with the matched group curative effect, observe treatment group total effective rate 95%, cure rate 80%, new drug is suffered from the high characteristics of performance curative effect in the near-sighted deficiency of both the liver and kidney of treatment, nebula removing pills is joined ZIJING FUMING YANTIE near-sighted deteriorated case is treated the characteristics of showing curative effect height, instant effect, and clinical generalization value is arranged very much.
The specific embodiment
The embodiment of the invention is as shown in the table:
Component Content (ratio of weight and number)
ZIJING 29 30 31
Concha Margaritifera 29 30 31
Concha Haliotidis 21 20 19
Fructus Lycii 14 15 16
Fructus Leonuri 15 14 16
Semen Plantaginis 16 14 15
Semen Cuscutae 15 16 14
Fructus Rosae Laevigatae 14 16 15
Fructus Mori 14 15 16
Fructus Rubi 14 15 16
Fructus Alpiniae Oxyphyllae 14 15 16
Fructus Schisandrae Chinensis 16 14 15
Os Draconis 9 10 11
Endoconcha Sepiae 11 9 10
Herba Cistanches 9 10 11
Radix Rehmanniae Preparata 11 10 9
Flos Chrysanthemi 9 10 11
Radix Rehmanniae Preparata 10 9 11
Fructus Corni 11 9 10
Radix Polygoni Multiflori Preparata 9 10 11
Radix Bupleuri 9 10 11
White peony root 10 11 9
Radix Asparagi 10 11 9
Radix Ophiopogonis 10 11 9
Rhizoma Acori Graminei 9 10 11
Radix Polygalae 9 11 10
Radix Saposhnikoviae 10 9 11
Faeces Vespertilionis 9 10 11
Cortex Moutan 9 10 11
Rhizoma Alismatis 11 9 10
Poria cum Radix Pini 11 9 10
The Radix Astragali 10 9 11
Radix Codonopsis 10 11 9
Radix Angelicae Sinensis 10 11 9
Rhizoma Chuanxiong 11 9 10
The Rhizoma Anemarrhenae 11 9 10
Cortex Phellodendri 9 10 11
Radix Aucklandiae (Radix Vladimiriae) 9 11 10
Herba Dendrobii 10 9 11
Caulis Spatholobi 9 10 11
Radix Glycyrrhizae 4 5 6
Herba Asari 2 3 4

Claims (3)

1, a kind of nebula removing pills, it is characterized in that the pill that adopts following ratio of weight and number component to make: ZIJING 29-31, Concha Margaritifera 29-31, Concha Haliotidis 19-21, Fructus Lycii, Fructus Leonuri, Semen Plantaginis, Semen Cuscutae, Fructus Rosae Laevigatae, Fructus Mori, Fructus Rubi, Fructus Alpiniae Oxyphyllae, each 14-16 of Fructus Schisandrae Chinensis, Os Draconis, Endoconcha Sepiae, Herba Cistanches, Radix Rehmanniae Preparata, Flos Chrysanthemi, Radix Rehmanniae Preparata, Fructus Corni, Radix Polygoni Multiflori Preparata, Radix Bupleuri, white peony root, Radix Asparagi, Radix Ophiopogonis, Rhizoma Acori Graminei, Radix Polygalae, Radix Saposhnikoviae, Faeces Vespertilionis, Cortex Moutan, Rhizoma Alismatis, Poria cum Radix Pini, the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Rhizoma Anemarrhenae, Cortex Phellodendri, Radix Aucklandiae (Radix Vladimiriae), Herba Dendrobii, each 9-11 of Caulis Spatholobi, Radix Glycyrrhizae 4-6, Herba Asari 2-4
Described a kind of ZIJING, the bright whole eyeball of the healthy cattle of Bovidae, Ziyang, or horse, donkey, the healthy bright whole eyeball of mule.
2, nebula removing pills according to claim 1 is characterized in that the Ziyang bright whole eyeball of healthy cattle is called for short ZIJING, the place of production: ground such as Ziyang, Shaanxi, Shitai County, Anhui, enshi.
3, nebula removing pills according to claim 1 and 2, it is characterized in that the described ZIJING four seasons all can gather, when slaughtering an ox fresh and alive eyeball is extracted, the flush away bloodstain removes clean lipid foreign material on every side, wraps up, dries in the shade with Medulla Junci behind the salting, the freezing antistaling storing, avoid with fiery baking, Exposure to Sunlight, wind in case break rottenly, the bright complete crack-free person of color be a good merchantable brand, the genus ophthalmic remedy.
CNB2005100128627A 2005-09-29 2005-09-29 Nebula removing pills Expired - Fee Related CN1310667C (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101897896A (en) * 2010-08-04 2010-12-01 北京科莱博医药开发有限责任公司 Chinese medicinal composition for treating cataract and medicinal preparation and preparation method thereof
CN102940745A (en) * 2012-12-04 2013-02-27 刘顺慧 Pill for treating blepharospasm
CN105597001A (en) * 2016-01-22 2016-05-25 李先强 Medicine for treating paralytic strabismus
CN105878627A (en) * 2016-06-03 2016-08-24 马小英 Traditional Chinese medicine formula for treating myopic disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1043846C (en) * 1994-04-14 1999-06-30 徐德贵 Traditional Chinese medicine preparation for mainly curing myopia
CN1054751C (en) * 1994-09-02 2000-07-26 覃刚 Oral medicine for curing vision

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101897896A (en) * 2010-08-04 2010-12-01 北京科莱博医药开发有限责任公司 Chinese medicinal composition for treating cataract and medicinal preparation and preparation method thereof
CN102940745A (en) * 2012-12-04 2013-02-27 刘顺慧 Pill for treating blepharospasm
CN102940745B (en) * 2012-12-04 2014-10-08 刘顺慧 Pill for treating blepharospasm
CN105597001A (en) * 2016-01-22 2016-05-25 李先强 Medicine for treating paralytic strabismus
CN105878627A (en) * 2016-06-03 2016-08-24 马小英 Traditional Chinese medicine formula for treating myopic disease

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