CN1754577A - 造影剂 - Google Patents

造影剂 Download PDF

Info

Publication number
CN1754577A
CN1754577A CN200510069770.2A CN200510069770A CN1754577A CN 1754577 A CN1754577 A CN 1754577A CN 200510069770 A CN200510069770 A CN 200510069770A CN 1754577 A CN1754577 A CN 1754577A
Authority
CN
China
Prior art keywords
contrast agent
magnetic resonance
ray
gadolinium
tomography
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200510069770.2A
Other languages
English (en)
Inventor
沃尔特·梅曾多弗
伯恩德·奥内索格
斯蒂芬·沙勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens AG
Original Assignee
Siemens AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens AG filed Critical Siemens AG
Publication of CN1754577A publication Critical patent/CN1754577A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

本发明涉及一种造影剂，它含有一种呈钆化学化合物形式且对于X射线－计算机断层照相术有效的成分，它包括至少一种添加剂，该添加剂能阻止造影剂在磁共振X线断层照相中的使用。

Description

造影剂
本发明涉及一种造影剂，它含有一种呈钆化学化合物形式并对X射线-计算机断层照相术是有效的成分。
在造影医学诊断方法中，如X射线-计算机断层照相术和磁共振断层照相术中，都使用造影剂来增加所获照片中的对比度。在X射线-计算机断层照相术中广泛使用的造影剂中含有作为活性成分的结合的碘。可是这种造影剂对肾机能不全的病人只能够适于有限的剂量范围，并引起副作用。
各种研究证实，钆适合作为X射线-计算机断层照相术中的造影活性物质。选择一种钆的化合物作为造影活性物质就能阻止因含碘造影剂所引起的对患者的伤害。
DE 298 00 160 U1公开了开始所述技术的一种造影剂。
EP 1 378 239 A1描述了一种用于成像方法，特别是用于磁共振断层照相术和X射线显示术中的造影剂，其含有一种超顺磁粒子。这种超顺磁粒子会显示出一种不同于躯体本身的骨组织的X-射线吸收性，这就改善对比度。此外，在粒子上还另覆盖有活性物质，并且优选使用二膦酸作为所述活性物质。二膦酸可使造影剂优先富集在骨组织中，因此其特别适合用于检测骨肿瘤转移。对于利用磁共振成像是通过超顺磁粒子而引起测量信号的放大。
EP 0 998 864 A1描述了一种磁共振断层照相术造影剂，其包含至少一种铁磁性的和/或超顺磁的以及至少一种顺磁的成分。其中推荐使用铁或者铁的氧化物作为铁磁性或者超顺磁的物质。作为顺磁性物质使用钆。与只含有其中一种成分的造影剂相比，通过选择特殊的成分浓度就能使所需的总浓度更低。所述的造影剂特别适合用于空腔内的内窥镜检查。
磁共振断层照相术通常是使用基于钆的造影剂，因为钆的顺磁特性会在T1加权的照像中增强磁共振信号。如果钆化合物浓度达到最佳就能增强磁共振信号，这样就会得到有更好的对比度的照片。为了在X射线-计算机断层照相中也能使用相同的低浓度的造影剂，则造影剂中用于磁共振X线断层照相术的钆化合物最佳浓度自然是太低。与磁共振检测相比较，对于用于X射线-计算机断层照相术中的足够高的钆化合物浓度会导致造影剂费用相应提高，这样不经济。因此，对需要制备用于X射线-计算机断层照相术的相应高浓缩造影剂，必须提供价格堪与低浓度造影剂媲美的高浓度造影剂，由此才能使X射线-计算机断层照相仪器的经营者同样也有利可图。当然造影剂生产者也承担着磁共振断层照相仪的操作者以稀释方式使用高浓缩的造影剂，从而造影剂生产者可避免由销售低浓缩造影剂而得到的收入。而在磁共振断层照相中使用高浓缩的造影剂是不可取的。
本发明的任务在于对用于X射线-计算机断层照相术的并含有钆化学化合物形式的有效成分的造影剂按如下进行，即在磁共振断层照相术进行检测中，阻止使用造影剂。
该任务可通过权利要求1中所述的造影剂来解决。这种添加剂的使用强烈改变了磁共振断层照片术所得到的照片，从而用于诊断是不可取的。
优选是选择添加剂由一种具有超顺磁特性化合物组成。由此使得在T1-加权的磁共振照片上明亮显示的区域明显变暗，因此使这些照片用于诊断是不可取的。
一种实施例是选择一种含有超顺磁的Fe2O3颗粒的添加剂。这种颗粒的磁性会产生一种加速横向核自旋-松弛，从而会引起磁共振断层照相术中信号的显著减弱。这样，在所得图片中那些因使用低浓缩的基于钆的造影剂后的暗色区域成为明亮。由此，使用混有Fe2O3颗粒的造影剂，使得为诊断分析而用的精确的磁共振断层照相的图片是不可取的。对于含Fe2O3颗粒的造影剂在X射线-计算机断层照相中的应用并无苛求，因为通过Fe2O3颗粒的X-射线吸收性并没有发生明显的改变。这里只有钆化合物是起决定性作用的。

Claims (3)

1.一种造影剂，其含有一种钆的化学化合物形式的且对X射线-计算机断层照相术有效的成分，其特征在于，造影剂含有至少一种添加剂，其能防止造影剂在磁共振断层照相中的使用。
2.根据要求1的造影剂，其特征在于，添加剂含有具超顺磁性的化合物。
3.根据要求2的造影剂，其特征在于，添加剂含有超顺磁Fe2O3。
CN200510069770.2A 2004-03-03 2005-03-03 造影剂 Pending CN1754577A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004010387A DE102004010387A1 (de) 2004-03-03 2004-03-03 Kontrastmittel für die Röntgen-Computertomographie
DE102004010387.9 2004-03-03

Publications (1)

Publication Number Publication Date
CN1754577A true CN1754577A (zh) 2006-04-05

Family

ID=34877307

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200510069770.2A Pending CN1754577A (zh) 2004-03-03 2005-03-03 造影剂

Country Status (3)

Country Link
US (1) US20050238583A1 (zh)
CN (1) CN1754577A (zh)
DE (1) DE102004010387A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013001005A1 (de) 2013-01-22 2014-07-24 Horst Kisch Verfahren für eine tumorselektive Röntgen-Computertomographie

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4778893A (en) * 1992-07-21 1994-02-14 General Hospital Corporation, The System of drug delivery to the lymphatic tissues
DE4428851C2 (de) * 1994-08-04 2000-05-04 Diagnostikforschung Inst Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie
DE29800160U1 (de) * 1998-01-08 1998-03-12 Heintzen, Paul, Prof. Dr., 24211 Preetz Röntgenkontrastmittel für Angiographie und Computertomographie
EP0988864A1 (de) * 1998-09-23 2000-03-29 Luboldt, Wolfgang, Dr.med. Dipl.-Phys. Kontrastmittel für die Magnetresonanztomographie
ES2280355T3 (es) * 2000-04-12 2007-09-16 Liplasome Pharma A/S Sistema de administracion de medicamentos basados en lipidos para su utilizacion en la piel.
DE10222481A1 (de) * 2002-05-22 2003-12-04 Eucro Europe Contract Res Gmbh Kontrastmittel für die Verwendung in bildgebenden Verfahren
TW593158B (en) * 2003-07-31 2004-06-21 Ind Tech Res Inst Magnetic nanoparticle

Also Published As

Publication number Publication date
US20050238583A1 (en) 2005-10-27
DE102004010387A1 (de) 2005-09-22

Similar Documents

Publication Publication Date Title
Iyad et al. Gadolinium contrast agents-challenges and opportunities of a multidisciplinary approach: Literature review
González-Gómez et al. Development of superparamagnetic nanoparticles coated with polyacrylic acid and aluminum hydroxide as an efficient contrast agent for multimodal imaging
Garcia et al. Biological effects of MRI contrast agents: gadolinium retention, potential mechanisms and a role for phosphorus
Ahmad et al. Potential dual imaging nanoparticle: Gd2O3 nanoparticle
Gilad et al. MR tracking of transplanted cells with “positive contrast” using manganese oxide nanoparticles
Kim et al. Recent development of nanoparticles for molecular imaging
Wei et al. Exceedingly small iron oxide nanoparticles as positive MRI contrast agents
Adamiano et al. On the use of superparamagnetic hydroxyapatite nanoparticles as an agent for magnetic and nuclear in vivo imaging
Thomas et al. Innovative magnetic nanoparticles for PET/MRI bimodal imaging
Liu et al. Recent advances in ytterbium‐based contrast agents for in vivo X‐ray computed tomography imaging: promises and prospects
Cai et al. Positive magnetic resonance angiography using ultrafine ferritin-based iron oxide nanoparticles
Jung et al. Intraperitoneal injection improves the uptake of nanoparticle-labeled high-density lipoprotein to atherosclerotic plaques compared with intravenous injection: a multimodal imaging study in ApoE knockout mice
IS4790A (is) Málmsamstæður sem innihalda Perflúoróalkýl og notkun þeirra við segulsneiðmyndunar-greiningar
WO1993007905A3 (en) Treated apatite particles for medical diagnostic imaging
Ahmad et al. Ni-Fe2O4 nanoparticles as contrast agents for magnetic resonance imaging
Kiani et al. Main applications of hybrid PET‐MRI contrast agents: a review
Kalidoss et al. Theranostic calcium phosphate nanoparticles with potential for multimodal imaging and drug delivery
CN107955606A (zh) 一种双稀土掺杂碳点磁共振/ct/荧光多模态成像探针及其制备方法
Ashokan et al. Development and haematotoxicological evaluation of doped hydroxyapatite based multimodal nanocontrast agent for near-infrared, magnetic resonance and X-ray contrast imaging
CN102526769A (zh) 同时用于ct与mri的双显影剂及其制作方法
Lee et al. d‐Glucuronic Acid Coated Gd (IO3) 3· 2H2O Nanomaterial as a Potential T1 MRI‐CT Dual Contrast Agent
Gowtham et al. Impact of nanovectors in multimodal medical imaging.
Gholami et al. A radio-nano-platform for T1/T2 dual-mode PET-MR imaging
Cormode et al. Nanoparticle contrast agents for CT: their potential and the challenges that lie ahead
CN1754577A (zh) 造影剂

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication