CN1738651A - 具有改善的生物耐受性的造影剂制剂 - Google Patents

具有改善的生物耐受性的造影剂制剂 Download PDF

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Publication number
CN1738651A
CN1738651A CNA2003801090166A CN200380109016A CN1738651A CN 1738651 A CN1738651 A CN 1738651A CN A2003801090166 A CNA2003801090166 A CN A2003801090166A CN 200380109016 A CN200380109016 A CN 200380109016A CN 1738651 A CN1738651 A CN 1738651A
Authority
CN
China
Prior art keywords
tris
preparation
iosimenol
citric acid
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2003801090166A
Other languages
English (en)
Chinese (zh)
Inventor
米洛斯·索瓦克
艾伦·L·塞利格森
罗纳德·C·特里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biophysica Foundation
Original Assignee
Biophysica Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biophysica Foundation filed Critical Biophysica Foundation
Publication of CN1738651A publication Critical patent/CN1738651A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CNA2003801090166A 2002-12-12 2003-11-07 具有改善的生物耐受性的造影剂制剂 Pending CN1738651A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US43287902P 2002-12-12 2002-12-12
US60/432,879 2002-12-12
US10/701,586 US7250153B2 (en) 2002-12-12 2003-11-05 Contrast media formulations having improved biological tolerance
US10/701,586 2003-11-05
PCT/US2003/035762 WO2004054637A2 (en) 2002-12-12 2003-11-07 Contrast media formulations having improved biological tolerance

Publications (1)

Publication Number Publication Date
CN1738651A true CN1738651A (zh) 2006-02-22

Family

ID=34107426

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2003801090166A Pending CN1738651A (zh) 2002-12-12 2003-11-07 具有改善的生物耐受性的造影剂制剂

Country Status (18)

Country Link
US (1) US7250153B2 (enExample)
EP (1) EP1575621B1 (enExample)
JP (1) JP2006509841A (enExample)
KR (1) KR101067159B1 (enExample)
CN (1) CN1738651A (enExample)
AT (1) ATE447416T1 (enExample)
AU (1) AU2003295442B2 (enExample)
CA (1) CA2509035C (enExample)
CY (1) CY1110105T1 (enExample)
DE (1) DE60329939D1 (enExample)
DK (1) DK1575621T3 (enExample)
ES (1) ES2333863T3 (enExample)
IL (1) IL169119A (enExample)
NO (1) NO332350B1 (enExample)
NZ (1) NZ541139A (enExample)
PT (1) PT1575621E (enExample)
SI (1) SI1575621T1 (enExample)
WO (1) WO2004054637A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102802671A (zh) * 2010-03-23 2012-11-28 通用电气医疗集团股份有限公司 稳定的x射线诊断组合物的制备

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070015517A (ko) * 2004-03-11 2007-02-05 말린크로트, 인코포레이티드 요오드화된 단량체 및 이량체의 혼합물을 포함하는 ｘ-선조영제 제형
FR2899581B1 (fr) * 2006-04-07 2008-06-27 Guerbet Sa Procede d'atomisation du ioxilan
WO2009091758A1 (en) 2008-01-14 2009-07-23 Mallinckrodt Inc. Process for the preparation of iosimenol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR222337A1 (es) * 1978-07-04 1981-05-15 Nyegaard & Co As Procedimiento para preparar una solucion esteril inyectable fisiologicamente aceptable de un agente de contraste de rayos x
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
KR19990022943A (ko) * 1995-06-16 1999-03-25 밀로스 소박 비이온성 조영제로서의 포르밀 유도체
DE19648650C2 (de) 1996-01-29 1998-07-02 Schering Ag Puffersysteme und deren Verwendung zur Stabilisierung pharmazeutischer Zubereitung

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102802671A (zh) * 2010-03-23 2012-11-28 通用电气医疗集团股份有限公司 稳定的x射线诊断组合物的制备
CN102802671B (zh) * 2010-03-23 2015-07-22 通用电气医疗集团股份有限公司 稳定的x射线诊断组合物的制备
US11185598B2 (en) 2010-03-23 2021-11-30 Ge Healthcare As Preparation of stabilised x-ray diagnostic composition

Also Published As

Publication number Publication date
SI1575621T1 (sl) 2010-01-29
CY1110105T1 (el) 2015-01-14
US20050025711A1 (en) 2005-02-03
NO20053343D0 (no) 2005-07-08
AU2003295442A1 (en) 2004-07-09
NO20053343L (no) 2005-09-08
WO2004054637A3 (en) 2004-09-16
CA2509035C (en) 2011-07-19
WO2004054637A2 (en) 2004-07-01
US7250153B2 (en) 2007-07-31
IL169119A0 (en) 2007-07-04
PT1575621E (pt) 2009-11-13
CA2509035A1 (en) 2004-07-01
EP1575621B1 (en) 2009-11-04
EP1575621A4 (en) 2008-11-26
KR20050088312A (ko) 2005-09-05
ATE447416T1 (de) 2009-11-15
DE60329939D1 (de) 2009-12-17
KR101067159B1 (ko) 2011-09-22
ES2333863T3 (es) 2010-03-02
NO332350B1 (no) 2012-09-03
EP1575621A2 (en) 2005-09-21
JP2006509841A (ja) 2006-03-23
DK1575621T3 (da) 2009-12-14
AU2003295442B2 (en) 2008-11-06
IL169119A (en) 2010-06-16
NZ541139A (en) 2008-07-31

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WD01 Invention patent application deemed withdrawn after publication