CN1720974A - Chinese medicinal composition for treating ascites due to cirrhosis - Google Patents
Chinese medicinal composition for treating ascites due to cirrhosis Download PDFInfo
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- CN1720974A CN1720974A CNA2005100498963A CN200510049896A CN1720974A CN 1720974 A CN1720974 A CN 1720974A CN A2005100498963 A CNA2005100498963 A CN A2005100498963A CN 200510049896 A CN200510049896 A CN 200510049896A CN 1720974 A CN1720974 A CN 1720974A
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Abstract
The invention provides a Chinese medicinal composition for treating cirrhosis and ascites, which comprises the following raw materials (by weight portion), Indian stringbush root 1-20, earthworm 1-22, pokeberry 1-20, radical lobelia 1-40, turtle shell 1-30, ground beetle 1-20, pangolin scales 1-22.
Description
One, affiliated technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of hepatitis, refer in particular to a kind of Chinese medicine composition for the treatment of cirrhotic ascites.
Two, background technology
Under normal circumstances, intraperitoneal has the liquid of 50ML approximately, to the enterokinesia lubricate.If the peritoneal fluid scale of construction is called ascites when surpassing 200ML, it is one of the most outstanding performance of liver cirrhosis patient.The former of ascites formation spills increase, aldosterone and vassopressin increase etc. because of hypoproteinemia, portal vein increased pressure, liver lymph fluid.First three kind factor is called the precipitating factor that ascites forms playing a leading role in early days that ascites forms; Two kinds of factors lasting existence of then tying ascites then plays an important role, and can be described as the factor of keeping.Because the combined effect of these two big class factors causes ascites to form and continues to exist.Liver cirrhosis, the present doctor trained in Western medicine of hepatic ascites still do not have good therapy, adopt defeated albumin more, beat hepatic such as diuresis pin and treat, though can temporarily remove patient's misery, but cure the symptoms, not the disease, easily repeatedly, cost an arm and a leg, make most patients can't afford, too intensive diuresis also often causes the effective blood volume deficiency, causes renal failure and electrolyte disturbance, and brings out hepatic coma easily.Therefore, it is very significant developing a kind of special treating the liver sclerosis ascites special effect Chinese.Chinese patent once disclosed " a kind of preparation method for the treatment of the cirrhotic ascites pill " (application number: 991091728, publication number: CN1277862A, open day: on December 27th, 2000), the contain Semen Pharbitidis, face that cure mainly that ascites disappears are wrapped up in and are simmered that Radix Kansui, vinegar are fried Flos Genkwa, vinegar is fried the Radix Euphorbiae Pekinensis, Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, Semen Arecae, succinum, the liver rehabilitation after curing mainly hepatic ascites and disappearing contain that Cordyceps, Squama Manis system, Carapax Trionycis system, Carapax et Plastrum Testudinis system, Semen Persicae, Radix Salviae Miltiorrhizae, a shell burn, rhizoma sparganic, Rhizoma Curcumae, Cortex Moutan, parch skin.
Three, summary of the invention
The object of the present invention is to provide a kind of therapeutic effect remarkable, the medicine source is extensive, the Chinese medicine composition of treatment cirrhotic ascites with low cost.
For achieving the above object, the solution that the present invention takes is: a kind of Chinese medicine composition for the treatment of cirrhotic ascites, and it is made up of the following weight proportion raw material: Radix Wikstroemae 1-20, Pheretima 1-22, Radix Phytolaccae 1-20, Herba Lobeliae Chinensis 1-40, Carapax Trionycis 1-30, Eupolyphaga seu steleophaga 1-20, stir-baked SQUAMA MANITIS 1-22.
Among the present invention: the Radix Wikstroemae water decoction all has inhibitory action to mice MSA1, U14 and S180, wherein the inhibitory action rate to MSA1 is 45.4%, the wikstromol that contains shows medium inhibitory action to mice P388, tricin has inhibitory action to P388, wickstoemin has diuresis to Canis familiaris L., root bark has stimulation to skin, its resinous stronger discharge function arranged.Root and peel of stem water decoction have obvious inhibitory action to staphylococcus aureus in vitro, also can suppress large intestine, pseudomonas aeruginosa.
Pheretima has thrombolytic and anticoagulation.Hot water preserved material or pure preserved material have the effect that brings high blood pressure down, and this effect slowly and lastingly.Pheretima decocting liquid or earthworm injection tool be sharp sodium, diuresis and triglyceride reducing effect recklessly.That extract has is analgesic, convulsion, the effect of inhibition growth of tumour cell, can strengthen the activity of oxide dismutase (SOD), glutathion reductase (GR), catalase (CAT), glutathion peroxidase (GSH-PX), remove free radical, anti peroxidation of lipid damage, thereby up to the effect of relieving cough and asthma.
Phytolaccanol extractum and extract all have the obvious anti-inflammatory and anti effect.The Radix Phytolaccae mitogen can induce human peripheral lymphocyte to transform in vitro, to T cell and the equal mitosis effect of B cell, can stimulate the G cell to produce IG, stimulate mice spleen lymphocytes proliferation and induce splenocyte to produce interleukin matter, the inducing mouse peritoneal macrophage produces the interleukin dish.Decoct, preserved material, tincture all have obvious phlegm-dispelling functions, and the mouse cough that the alkaloid part causes the ammonia mist has obvious antitussive effect.Decoct and tincture have certain inhibitory action external to hemophilus influenza, pneumonia bar, Neisseria.The water logging agent is to Lan Shi tinea bacterium, Du Ang Shi budlet spore tinea bacterium difficult to understand have inhibitory action perhaps.Radix Phytolaccae protein has the effect of obviously anti-simple skin ulcer virus (II type), and the Radix Phytolaccae polysaccharide has certain antitumor action.
Lobelia chinensis decoct or therefrom isolated fumarase sodium, sodium succinate, P-hydroxybenzoic acid sodium, half an hour is oral or at injection subcutaneous injection simultaneously during snake venom before the injection snake venom respectively, and body is had the better protect effect.No matter the thick agent of Lobelia chinensis injection or oral all has remarkable and persistent diuresis, contained stalk dish alkali has nicotinic action, oral can appetite-suppressing.Partly middle repeatedly decocting in water precipitate with ethanol preparation has choleretic effect.Lobelia chinensis and extract thereof can also bring high blood pressure down, and strengthen the cardiac muscle power that contracts.Partly middle repeatedly decoct has slight diarrhea inducing effect.
Colla carapax Trionycis can make the mice content of hemoglobin obviously increase, and Turtle Shell is oral inhibited to mice transplanting benefit cancer MH134, and diameter of tumor is reduced, and weight significantly alleviates.
The Eupolyphaga seu steleophaga total alkaloids has blood vessel dilating, protection heart and brain anoxias (blood) effect; water extract energy significant prolongation bleeding time and recalcification time; obvious anticoagulant rate; having shown as antithrombotic forms and thrombolytic effect; decocting liquid can be regulated lipid metabolism; atherosclerosis is had retarding action, and extract has protective effect to the hepatic injury due to the D-galactose.Think that tentatively the fibrinolytic composition of intravital this kind of Eupolyphaga seu steleophaga is a kind of serine protease that the plasminogen activation is arranged, and the characteristics of urokinase type plasminogen activator are arranged.
Stir-baked SQUAMA MANITIS water extract-alcohol precipitation preparation can increase the large artery trunks blood flow, reduce Peripheral resistance, blood vessel wall there is direct dilating effect, decocting liquid has obvious prolongation mice and rat clotting time, the effect of blood viscosity lowering, aqueous extract or alcohol extract all have the effect of significant anti-Oleum Tiglii induced mice ear inflammation.
As improvement, Chinese medicine composition of the present invention is made up of the following weight proportion raw material: Radix Wikstroemae 1-20, Pheretima 1-22, Radix Phytolaccae 1-20, Herba Lobeliae Chinensis 1-40, Carapax Trionycis 1-30, Eupolyphaga seu steleophaga 1-20, stir-baked SQUAMA MANITIS 1-22, Semen Pharbitidis 1-40.
As further improvement, Chinese medicine composition of the present invention is made up of the following weight proportion raw material: Radix Wikstroemae 1-20, Pheretima 1-22, Radix Phytolaccae 1-20, Herba Lobeliae Chinensis 1-40, Carapax Trionycis 1-30, Eupolyphaga seu steleophaga 1-20, stir-baked SQUAMA MANITIS 1-22, Semen Pharbitidis 1-40 ， Cortex araliae chinensis 1-20.
As step improvement again, Chinese medicine composition of the present invention is made up of the following weight proportion raw material: Radix Wikstroemae 1-20, Pheretima 1-22, Radix Phytolaccae 1-20, Herba Lobeliae Chinensis 1-40, Carapax Trionycis 1-30, Eupolyphaga seu steleophaga 1-20, stir-baked SQUAMA MANITIS 1-22, Semen Pharbitidis 1-40 ， Cortex araliae chinensis 1-20, Polyporus 1-28.
As better improvement, Chinese medicine composition of the present invention is made up of the following weight proportion raw material: Radix Wikstroemae 1-20, Pheretima 1-22, Radix Phytolaccae 1-20, Herba Lobeliae Chinensis 1-40, Carapax Trionycis 1-30, Eupolyphaga seu steleophaga 1-20, stir-baked SQUAMA MANITIS 1-22, Semen Pharbitidis 1-40 ， Cortex araliae chinensis 1-20, Polyporus 1-28, Semen Pharbitidis 1-20.
Semen Pharbitidis, Cortex araliae chinensis, Polyporus, Semen Pharbitidis all are the good medicine of treatment cirrhotic ascites.
The present invention with reference to the modern pharmacological research achievement, with clinical use makes treatment hepatitis specific drug through research for many years based on secret prescription handed down in the family from generation to generation.Said herbal medicine forms through scientific compatibility, cure mainly the hepatitis disease (popular name: ascites hepatitis, food stagnation hepatitis, jaundice hepatitis) of the caused acute icteric infectious hepatitis of various hepatitis viruss, type b chronic non-icteric type infectious hepatitis etc. and other type, be used in particular for treating cirrhotic ascites, its therapeutic effect is remarkable, the medicine source is extensive, and is with low cost.
The Chinese herbal medicine porphyrize of above-mentioned compatibility is sieved after by scientific process is carried out packing, every bag (bag) 35 gram, every bag of (bag) child divides and takes for six times, and the adult divides four times, divides every day after meal, secondary is swallowed with eliminating cold for resuscitation water after the supper morning.
Period in a medicine is forbidden diet acid, peppery, cigarette, wine, chicken, Oryza glutinosa, dried small shrimps and stodgy rice cake rice cake etc. and dry weight physical work, avoids clothes Folium Camelliae sinensis, Semen Glycines, fresh hen egg, preserved egg, river Eriocheir sinensis, tonic, Erythroculter ilishaeformis, Semen Phaseoli radiati Germinatus etc.
Clinical case statistics through system, effective more than 86% to the treatment cirrhotic ascites, under for example:
57 years old female patient, multi-treatment is invalid, after through 40 days clothes Drug therapy of the present invention, ascites slowly disappears, through 3 months medication treatment, B ultrasonic was normal again.
Four, the specific embodiment
Embodiment one: a kind of Chinese medicine composition for the treatment of cirrhotic ascites, (unit: gram) raw material is formed: Radix Wikstroemae 10, Pheretima 12, Radix Phytolaccae 10, Herba Lobeliae Chinensis 30, Carapax Trionycis 20, Eupolyphaga seu steleophaga 10, stir-baked SQUAMA MANITIS 12 by following each raw material for it.
Embodiment two: a kind of Chinese medicine composition for the treatment of cirrhotic ascites, (unit: gram) raw material is formed: Radix Wikstroemae 10, Pheretima 12, Radix Phytolaccae 10, Herba Lobeliae Chinensis 30, Carapax Trionycis 20, Eupolyphaga seu steleophaga 10, stir-baked SQUAMA MANITIS 12, Semen Pharbitidis 30 by following each raw material for it.
Embodiment three: a kind of Chinese medicine composition for the treatment of cirrhotic ascites, (unit: gram) raw material is formed: Radix Wikstroemae 10, Pheretima 12, Radix Phytolaccae 10, Herba Lobeliae Chinensis 30, Carapax Trionycis 20, Eupolyphaga seu steleophaga 10, stir-baked SQUAMA MANITIS 12, Semen Pharbitidis 30 ， Cortex araliae chinensis 10 by following each raw material for it.
Embodiment four: a kind of Chinese medicine composition for the treatment of cirrhotic ascites, (unit: gram) raw material is formed: Radix Wikstroemae 10, Pheretima 12, Radix Phytolaccae 10, Herba Lobeliae Chinensis 30, Carapax Trionycis 20, Eupolyphaga seu steleophaga 10, stir-baked SQUAMA MANITIS 12, Semen Pharbitidis 30 ， Cortex araliae chinensis 10, Polyporus 18 by following each raw material for it.
Embodiment five: a kind of Chinese medicine composition for the treatment of cirrhotic ascites, and (unit: gram) raw material is formed: Radix Wikstroemae 10, Pheretima 12, Radix Phytolaccae 10 by following each raw material for it, Herba Lobeliae Chinensis 30, Carapax Trionycis 20, Eupolyphaga seu steleophaga 10, stir-baked SQUAMA MANITIS 12, Semen Pharbitidis 30 ， Cortex araliae chinensis 10, Polyporus 18, Semen Pharbitidis 10.
Claims (5)
1, a kind of Chinese medicine composition for the treatment of cirrhotic ascites, it is characterized in that: it is made up of the following weight proportion raw material: Radix Wikstroemae 1-20, Pheretima 1-22, Radix Phytolaccae 1-20, Herba Lobeliae Chinensis 1-40, Carapax Trionycis 1-30, Eupolyphaga seu steleophaga 1-20, stir-baked SQUAMA MANITIS 1-22.
2, a kind of Chinese medicine composition for the treatment of cirrhotic ascites according to claim 1, it is characterized in that: it is made up of the following weight proportion raw material: Radix Wikstroemae 1-20, Pheretima 1-22, Radix Phytolaccae 1-20, Herba Lobeliae Chinensis 1-40, Carapax Trionycis 1-30, Eupolyphaga seu steleophaga 1-20, stir-baked SQUAMA MANITIS 1-22, Semen Pharbitidis 1-40.
3, a kind of Chinese medicine composition for the treatment of cirrhotic ascites according to claim 1, it is characterized in that: it is made up of the following weight proportion raw material: Radix Wikstroemae 1-20, Pheretima 1-22, Radix Phytolaccae 1-20, Herba Lobeliae Chinensis 1-40, Carapax Trionycis 1-30, Eupolyphaga seu steleophaga 1-20, stir-baked SQUAMA MANITIS 1-22, Semen Pharbitidis 1-40 ， Cortex araliae chinensis 1-20.
4, a kind of Chinese medicine composition for the treatment of cirrhotic ascites according to claim 1, it is characterized in that: it is made up of the following weight proportion raw material: Radix Wikstroemae 1-20, Pheretima 1-22, Radix Phytolaccae 1-20, Herba Lobeliae Chinensis 1-40, Carapax Trionycis 1-30, Eupolyphaga seu steleophaga 1-20, stir-baked SQUAMA MANITIS 1-22, Semen Pharbitidis 1-40 Cortex araliae chinensis 1-20, Polyporus 1-28.
5, a kind of Chinese medicine composition for the treatment of cirrhotic ascites according to claim 1, it is characterized in that: it is made up of the following weight proportion raw material: Radix Wikstroemae 1-20, Pheretima 1-22, Radix Phytolaccae 1-20, Herba Lobeliae Chinensis 1-40, Carapax Trionycis 1-30, Eupolyphaga seu steleophaga 1-20, stir-baked SQUAMA MANITIS 1-22, Semen Pharbitidis 1-40 Cortex araliae chinensis 1-20, Polyporus 1-28, Semen Pharbitidis 1-20.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100498963A CN100363034C (en) | 2005-05-29 | 2005-05-29 | Chinese medicinal composition for treating ascites due to cirrhosis |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100498963A CN100363034C (en) | 2005-05-29 | 2005-05-29 | Chinese medicinal composition for treating ascites due to cirrhosis |
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| Publication Number | Publication Date |
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| CN1720974A true CN1720974A (en) | 2006-01-18 |
| CN100363034C CN100363034C (en) | 2008-01-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2005100498963A Expired - Fee Related CN100363034C (en) | 2005-05-29 | 2005-05-29 | Chinese medicinal composition for treating ascites due to cirrhosis |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103385909A (en) * | 2013-07-17 | 2013-11-13 | 福州永同惠生物医药科技有限公司 | A pharmaceutical composition for the treatment of liver cirrhosis |
| CN104524262A (en) * | 2014-12-10 | 2015-04-22 | 黄平县兴且民族民间中草医药科学发展有限责任公司 | Traditional Chinese medicine for treating ascites due to cirrhosis |
| CN105412205A (en) * | 2015-12-18 | 2016-03-23 | 吴福 | Medicine for treating ascites due to cirrhosis |
| CN107998260A (en) * | 2017-12-21 | 2018-05-08 | 霍山县中医院 | Treat the Chinese medicinal formulae and application method of cirrhotic ascites |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1241416A (en) * | 1998-07-11 | 2000-01-19 | 王亮 | Preparation of medicine for hepatocirrhosis ascites |
| CN1259102C (en) * | 2004-09-24 | 2006-06-14 | 侯治民 | Pure Chinese medicine tablet for treating liver cirrhosis and complication |
-
2005
- 2005-05-29 CN CNB2005100498963A patent/CN100363034C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103385909A (en) * | 2013-07-17 | 2013-11-13 | 福州永同惠生物医药科技有限公司 | A pharmaceutical composition for the treatment of liver cirrhosis |
| CN103385909B (en) * | 2013-07-17 | 2015-09-30 | 福州永同惠生物医药科技有限公司 | A kind of pharmaceutical composition for the treatment of cirrhotic ascites |
| CN104524262A (en) * | 2014-12-10 | 2015-04-22 | 黄平县兴且民族民间中草医药科学发展有限责任公司 | Traditional Chinese medicine for treating ascites due to cirrhosis |
| CN105412205A (en) * | 2015-12-18 | 2016-03-23 | 吴福 | Medicine for treating ascites due to cirrhosis |
| CN107998260A (en) * | 2017-12-21 | 2018-05-08 | 霍山县中医院 | Treat the Chinese medicinal formulae and application method of cirrhotic ascites |
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| Publication number | Publication date |
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| CN100363034C (en) | 2008-01-23 |
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Granted publication date: 20080123 Termination date: 20120529 |