CN1720938A - Medicine for treating rheumatic arthritis and ankylosing spondylitis and its preparing process - Google Patents

Abstract

The invention discloses a medicine for treating rheumatoid arthritis and ankylosing spondylitis and its preparation method, which is mainly prepared from Clematis chinensis, arisaema tuber, cantharis, semen strychni, ledebouriella root, cassia twig and camphor by a predetermined weight ratio, the medicament fits for external use by patients.

Description

A kind of medicine for the treatment of rheumatic arthritis and ankylosing spondylitis and preparation method thereof

Technical field:

The present invention relates to a kind of medicine for the treatment of rheumatic arthritis and ankylosing spondylitis and preparation method thereof, belong to the field of Chinese medicines.

Background technology:

Wind and cold arthromyodynias such as rheumatism, rheumatoid arthritis and ankylosing spondylitis are all because of due to the wind-cold damp pathogen invasion and attack, as untimely treatment, pathogenic factor is invaded meridians or muscles and bones, will cause joint, spinal lesion, brings out inflammation, cause back or hip knee joint soreness, two sufficient numbnesses can not be walked.All kinds of antirheumatic medicines of Xiao Shouing in the market, although various in style, alleviate or the effect of relief of symptoms when accounting for but also can only reach, and can not control fully and eradicate, and the part Western medicine is toxic side effect still, when giving patient treatment, also can bring certain harm and discomfort.

Summary of the invention:

The Chinese medicine composition that the purpose of this invention is to provide a kind of more efficiently treatment rheumatism, rheumatoid arthritis and ankylosing spondylitis.

Another object of the present invention provides the preparation method of this Chinese medicine composition.

Medicine of the present invention selects Radix Clematidis, Herba Asari, Semen Sinapis Albae, Mylabris, Rhizoma Arisaematis, Radix Aconiti, Radix Aconiti Kusnezoffii, Semen Strychni, Olibanum, Myrrha, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Ramulus Cinnamomi, Camphora, Borneolum Syntheticum and Moschus to make up, make various efficacy of drugs produce coordinative role these drug regimens, thereby can effectively treat the recurrence of rheumatism, rheumatoid arthritis and ankylosing spondylitis disease.Wherein select for use Radix Clematidis to be because the Radix Clematidis nature and flavor are hot salty wet, go into 12 warps, have that diffusing wind dries, the promoting of the circulation of QI and removing the obstruction in the collaterals function, but diseases such as dispelling the wind and dampness pathogens arthralgia pain, paralysis, numbness.Selecting Herba Asari for use, is because Herba Asari is hot, warm, GUIXIN, lung, kidney channel.Expelling wind and cold, understand things pain-stopping, warming the lung for resolving phlegm function are arranged, can treat headache, toothache, rheumatic arthralgia.Semen Sinapis Albae, another name hot food, mustard, nature and flavor suffering, temperature are gone into lung meridian, eliminate the phlegm, cold expelling, detumescence, pain relieving, can treat diseases such as costa sternales distension, cough and asthma, carbuncle of yin nature sucutaneous nodule, and vinegar transfers external application can control the toxic swelling arthralgia pain.Mylabris, nature and flavor suffering, cold has removing blood stasis to amass, lose dead flesh, and diuresis, counteracting toxic substances function for oral administrationly cure mainly gonorrhea, mad dog is bitten, and external curing malignant boil scrofula is treated diseases such as malicious scabies.Rhizoma Arisaematis, nature and flavor suffering, hardship, temperature are gone into lung, liver, spleen channel; Drying dampness to eliminate phlegm, relieving convulsion dispeling the wind, wind-phlegm heap soil or fertilizer over and around the roots in curing mainly, dizziness due to wind-phlegm, damp-phlegm cough with asthma, external application detumescence pain.Radix Aconiti Kusnezoffii is conventional Chinese medicine, and Compendium of Material Medica is listed in the poisonous weeds class, under " Aconitum carmichjaelii Debx. " item, and original name " Radix Aconiti Kusnezoffii ", the big heat of nature and flavor, suffering, very toxic, go into spleen, lung, bladder three warmers four warps, expelling wind and removing dampness, the meridian dredging can be treated the arthralgia that rheumatism causes, colic of cold type stomachache, hemiplegia.Semen Strychni, the another name Semen Strychni, the nature and flavor bitter cold, poisonous, go into liver, spleen channel, dispelling wind and relieving pain, relaxing muscles and tendons and activating QI and blood in the collateral are arranged, the heat in blood of loosing, the malicious function of subsiding a swelling cures mainly diseases such as numb limbs and tense tendons, muscles and bones contracture, arthralgia, traumatic injury, swollen ulcer drug.Olibanum is decided disease and is chased after poison, regulating qi and activating blood, treatment traumatic injury, coagulation of QI-blood, carbuncle pyogenic infections from tumour or sore.The Radix Angelicae Dahuricae, the another name Radix Angelicae Dahuricae (Radix Heraclei Scabridi), property and flavor of peppery and warm is gone into lung, stomach warp, delivers diffusing wind, and reducing swelling and alleviating pain cures mainly headache due to common cold, supraorbital bone pain, carbuncle skin infection.Radix Saposhnikoviae, the nature and flavor suffering, Gan Wen delivers diffusing wind, wins wet spasmolytic, cures mainly the headache due to affection of exogenous wind-cold or the rheumatism, dizzy arthralgia, diseases such as tetanus.Ramulus Cinnamomi, property acrid-sweet flavor temperature is gone into the heart, lung, urinary bladder channel, and the function of invigorating YANG and expelling the pathogenic factor in the superficies, promoting the flow of QI-blood by warming the meridian is arranged, and cures mainly anemofrigid-damp arthralgia, phlegm retention water-retention, exterior deficiency spontaneous perspiration.Camphora, another name ocean ice, nature and flavor suffering, heat, the dehumidifying parasite killing, the pain relieving of having one's ideas straightened out, the disturbance of lower legs due to pathogenic cold and dampness is controlled in external, sore scabies, diseases such as dental caries.Borneolum Syntheticum, nature and flavor suffering, hardship are slightly cold, and heat clearing away is sensible, and reducing swelling and alleviating pain can be treated coma, laryngopharynx swelling and pain, conjunctival congestion, skin infection.Moschus, nature and flavor suffering, temperature, having has one's ideas straightened out ward off move, the blood circulation promoting and dispersing pathogen accumulation function, can treat the calentura coma, apoplexy syncope due to accumulation of phlegm, infantile convulsion, trusted subordinate's sudden pain, traumatic injury skin infection.

The consumption of drug component of the present invention is groped Test Summary in a large number through the inventor and must be come from, and each amounts of components all has curative effect preferably in following weight range.

Radix Clematidis 8-12 gram Herba Asari 8-12 gram Semen Sinapis Albae 25-35 gram

Mylabris 0.7-1 gram Rhizoma Arisaematis 8-12 gram Radix Aconiti 8-12 gram

Radix Aconiti Kusnezoffii 8-12 gram Semen Strychni 3-5 gram Olibanum 2-4 gram

Myrrha 2-4 gram Radix Angelicae Dahuricae 3-5 gram Radix Saposhnikoviae 8-12 gram

Ramulus Cinnamomi 7-10 gram Camphora 1-3 gram Borneolum Syntheticum 1.8-2.1 gram

Moschus 0.02-0.04 gram

The preparation method of medicine of the present invention is as follows:

One, select materials:

1, Radix Clematidis is chosen the dry root and rhizome of Radix Clematidis, and many few person of the aerial stem of plant is as the criterion and elongated with the rhizome rootlet, rejects dirty face and impurity.

2, Herba Asari, the another name Herba Asari originates in Jilin Fusong, flat, the Haicheng City of Liaoning lid, chooses root color sallow, and the leaf color is green, the peppery numb tongue person's of acrid in the mouth Herba Asari.

3, Mylabris, it is complete greatly to choose body, the Mylabris of decorative pattern distinctness.

4, Rhizoma Arisaematis, choose evenly big, matter heavily fortified point, the Rhizoma Arisaematis that color is white.

5, Radix Aconiti Kusnezoffii, choose big, solid Radix Aconiti Kusnezoffii.

6, Semen Strychni is chosen a big plumpness, the Semen Strychni of the green young pilose antler of close life.

7, Olibanum is chosen faint yellowly, and section is translucent, and matter is hard and crisp, strongly fragrant Olibanum.

8, the Radix Angelicae Dahuricae, it is thick to choose root, and the head class is square, mealiness foot, the Radix Angelicae Dahuricae that fragrance is dense.

9, Radix Saposhnikoviae is the dry root of Umbelliferae herbaceos perennial, and it is evenly long to choose bar, is not with the reed head, and body is gentle, the section yellow-white, and there is the Radix Saposhnikoviae of yellow decorative pattern the centre.

10, Ramulus Cinnamomi is chosen the branch delicacy, and color is reddish brown, the Ramulus Cinnamomi of no deadwood.

11, Camphora, it is dried pure white, pure to choose body, the Camphora of no moisture and impurity.

12, Borneolum Syntheticum selects for use sheet big, and color is white, the fragrant cool Borneolum Syntheticum of gas.

Two, preparation

1,, cleans and dry with the medicine full scale clearance impurity in the component.

2,, pulverize to grind and be powder by with measuring foot.

3, divide collation package, every bag is 30 grams.

The specific embodiment:

[embodiment 1] animal experiment data

A, get 10 of local rabbit, male and female dual-purpose, body weight 2-3kg.

B, pull out clean abdominal part, each 3-5cm of buttocks fine hair ²

C, with boiled water medicated powder is adjusted to the thick paste shape, after waiting to cool, ointment is affixed on the Wu Maochu of abdominal part and buttocks, the thickness of ointment is 0.5cm, is covered in outside the ointment with thin film then.

D, remove ointment after the week, 10 all no abnormal reactions of rabbit.

[experimental example 2] clinical observation material

1, accepts outpatient service for medical treatment: (1) rheumatism, sciatica; (2) muscles and bones numbness, all kinds of joints pain, rheumatoid arthritis; (3) ankylosing spondylitis, aseptic osteonecrosis; (4) scapulohumeral periarthritis, hyperosteogeny, each 30 example of 4 class patients.Age 20-30 year 6 examples wherein, 31-40 year 8 examples, 41-50 year 11 examples, person's 5 examples more than 50 years old.

2, diagnostic criteria

Rheumatism, rheumatoid, arthritis, strong joint disease from rachitis and various types of shape are all attacked meridians or muscles and bones because of wind and cold, due to human body functional disorder, QI-blood circulation are smooth, the focus pilosity is born in limbs joint, shoulder week, cervical vertebra, vertebras etc. are located, the lighter's arthralgia, miserable numbness, weight person can cause joint deformity, amyotrophy, can not be upright, according to conditions of patients, clinically be divided into three types.

Patients with mild: at the disease initial stage, the course of disease is short, and treatment in time can obtain recovery from illness.

Moderate patient: morbidity 2-3, patient's arthralgia, miserable and with feeling of numbness.

Severe patient: the course of disease is more than 3 years, and patient's joint deformity is twisted, amyotrophy, and limitation of activity can not be walked.

3, Therapeutic Method

Edulcoration patient position, with medicine with boiled water furnishing paste, wait ointment not scald after, be affixed on painful area, the thickness of medicine is about 0.3-0.5cm, covers outside the ointment with plastic sheeting then, each 60-90 minute drug of topical application time, changing dressings is spaced apart 10 days, generally once takes effect.

Points for attention:

Idol has slight red point or vesicle symptom after A, the small number of patients medication, does not generally need special handling, and Lock-out after two days also can oral or external antiallergic agent.

B, as finding bullate patient, what blister was little does not deal with, and when blister is big, can do to discharge water with sterile needle behind the skin degerming, does not have the infection phenomenon.Clinical verification, bullate patient's effect is better obviously.

4, efficacy assessment standard

Cure: after the medication, the human body functional rehabilitation is normal, and joint, back, cervical vertebra, all no pain of shoulder did not have rebound phenomenon in 3 years.

Take a turn for the better: patient's human body progressively recovers normally, and joint, cervical vertebra, lumbar and back pain obviously alleviate, and the sick body position progressively takes a turn for the better.

5, therapeutic outcome

Through medication observation of curative effect after month:

Disease type	Cure		Take a turn for the better		Invalid		Effective percentage
								The example number	Cure rate	The example number	Improvement rate	The example number	Inefficiency
	Rheumatism, sciatica	25	83.3％	4	13.3％	1								3.3％	96.6％
Muscles and bones numbness, all kinds of arthralgia, rheumatoid arthritis							27	90％	2	6.6％	1	3.3％	96.6％
	Ankylosing spondylitis, aseptic osteonecrosis	15	50％	16	20％	9								30％	70％
Scapulohumeral periarthritis, hyperosteogeny							25	83.3％	2	6.6％	3	10％	89.9％

In one month treatment, at 4 kinds of dissimilar treatment of diseases, its efficacy result is:

1. rheumatism, sciatica are cured 25 examples, 4 examples that take a turn for the better, and invalid 1 example, cure rate is 83.3%, and improvement rate is 13.3%, and total effective rate is 96.6%.

2. muscles and bones numbness, all kinds of arthralgia, rheumatoid arthritis are cured 27 examples, 2 examples that take a turn for the better, and invalid 1 example, cure rate is 90%, and improvement rate is 6.6%, and total effective rate is 96.6%.

3. ankylosing spondylitis, aseptic osteonecrosis is cured 15 examples, 6 examples that take a turn for the better, invalid 9 examples, cure rate is 50%, and improvement rate is 20%, and total effective rate is 70%.

4. scapulohumeral periarthritis, hyperosteogeny are cured 25 examples, 2 examples that take a turn for the better, and invalid 3 examples, cure rate is 83.3%, and improvement rate is 6.6%, and total effective rate is 89.9%.

Claims (2)

1, a kind of medicine for the treatment of rheumatic arthritis and ankylosing spondylitis, it is characterized in that: it is made up of the component of following consumption:

Radix Clematidis 8-12 gram Herba Asari 8-12 gram Semen Sinapis Albae 25-35 gram

Mylabris 0.7-1 gram Rhizoma Arisaematis 8-12 gram Radix Aconiti 8-12 gram

Radix Aconiti Kusnezoffii 8-12 gram Semen Strychni 3-5 gram Olibanum 2-4 gram

Myrrha 2-4 gram Radix Angelicae Dahuricae 3-5 gram Radix Saposhnikoviae 8-12 gram

Ramulus Cinnamomi 7-10 gram Camphora 1-3 gram Borneolum Syntheticum 1.8-2.1 gram

Moschus 0.02-0.04 gram

2, according to the preparation method of the described medicine of claim 1, it is characterized in that: it comprises the following steps:

(1) select materials:

(1) Radix Clematidis is chosen the dry root and rhizome of Radix Clematidis, and many few person of the aerial stem of plant is as the criterion and elongated with the rhizome rootlet, rejects dirty face and impurity;

(2) Herba Asari, the another name Herba Asari originates in the Jilin Fusong, and Liaoning lid is flat, and root color sallow is chosen in Haicheng City, and the leaf color is green, the peppery numb tongue person's of acrid in the mouth Herba Asari;

(3) Mylabris, it is complete greatly to choose body, the Mylabris of decorative pattern distinctness;

(4) Rhizoma Arisaematis, choose evenly big, matter heavily fortified point, the Rhizoma Arisaematis that color is white;

(5) Radix Aconiti Kusnezoffii, choose big, solid Radix Aconiti Kusnezoffii;

(6) Semen Strychni is chosen a big plumpness, the Semen Strychni of the green young pilose antler of close life;

(7) Olibanum is chosen faint yellowly, and section is translucent, and matter is hard and crisp, strongly fragrant Olibanum;

(8) Radix Angelicae Dahuricae, it is thick to choose root, and the head class is square, mealiness foot, the Radix Angelicae Dahuricae that fragrance is dense;

(9) Radix Saposhnikoviae is the dry root of Umbelliferae herbaceos perennial, and it is evenly long to choose bar, is not with the reed head, and body is gentle, the section yellow-white, and there is the Radix Saposhnikoviae of yellow decorative pattern the centre;

(10) Ramulus Cinnamomi is chosen the branch delicacy, and color is reddish brown, the Ramulus Cinnamomi of no deadwood;

(11) Camphora, it is dried pure white, pure to choose body, the Camphora of no moisture and impurity;

(12) Borneolum Syntheticum selects for use sheet big, and color is white, the fragrant cool Borneolum Syntheticum of gas;

(2) preparation

(1), cleans and dry with the medicine full scale clearance impurity in the component;

(2), pulverize to grind and be powder by with measuring foot;

(3) divide collation package, every bag is 30 grams.