CN1720928A - Bone-setting pain-stopping plaster - Google Patents
Bone-setting pain-stopping plaster Download PDFInfo
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- CN1720928A CN1720928A CNA2005100405066A CN200510040506A CN1720928A CN 1720928 A CN1720928 A CN 1720928A CN A2005100405066 A CNA2005100405066 A CN A2005100405066A CN 200510040506 A CN200510040506 A CN 200510040506A CN 1720928 A CN1720928 A CN 1720928A
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Abstract
Disclosed is a bone-setting pain-stopping plaster which comprises the constituents (by weight portion) of Hippocampus japonicus 24-36 parts, dragon's blood resin 40-60 parts, black catechu 16-24 parts, frank incense 16-24 parts, rhizome of Sichuan lovage 16-24 parts, musk 4-6 parts, borneol 8-12 parts.
Description
Technical field
The present invention relates to a kind of medical external plaster, particularly a kind of fracture that cures mainly, the traumatology external plaster of traumatic injury, neck, shoulder, waist and leg pain and light tissue injury.
Background technology
Development along with transportation and change, all kinds of wounded patients are increasing, and become the damage of common pilosity because of partes corporis humani position fracture due to the wound, and traumatic condition complexity, serious, the comminuted fracture of especially serious long diaphysis and joint end, the treatment difficulty is bigger, causes the probability of bone delayed healing and bone does not connect to increase greatly.At present, be used for the treatment of relaxing muscles and tendons and activating QI and blood in the collateral, the expectorant pain relieving of loosing, traumatic injury is dampened pain, and the external preparation of rheumatic arthritis mainly contains traumatic injury plaster, ZHITONG GAO, black plaster etc.Though these external-applied ointments have certain curative effect, its result of use is also not obvious.Trace it to its cause, on the one hand, prescription is reasonable, and the use of some component is science not, and especially when component reached more than 50～60 kind, whole prescription was in a mess, and did not catch subject matter; On the other hand, aspect preparation technology, the plaster preparation generally all adopted the high temperature oil extraction process in the past, and it is very big that this technology often causes a lot of armaticity, effumability medicine to lose in preparation process, so not only wastes medical material, also reduced curative effect.In addition, existing this class ointment lead tolerance exceeds standard, and heavy metal pollution is serious; Easy pollution clothes during use; Cause skin allergy easily; And the needs that have are heated and are used inconvenience etc.
Summary of the invention
The object of the invention provides a kind of bone-setting pain-stopping plaster, and its purpose mainly is to improve fracture, the therapeutic effect of traumatologys such as traumatic injury, neck, shoulder, waist and leg pain and light tissue injury.
For achieving the above object, the technical solution used in the present invention is: a kind of bone-setting pain-stopping plaster,, fully mixed with substrate after pulverizing, extract, concentrating by pharmaceutical formulation, be coated with again, section and molding is characterized in that: described pharmaceutical formulation comprises following component and parts by weight content:
Principal agent: 24～36 parts of Hippocampus;
Adjuvant: 40～60 parts of Sanguis Draxonis, 16～24 parts in catechu, 16～24 parts of Olibanums;
Restriction medicine: 16～24 parts of Rhizoma Chuanxiongs;
Guiding drug: 4～6 parts in Moschus, 8～12 parts of Borneolum Syntheticums.
Related content in the technique scheme is explained as follows:
1, in order to make curative effect reach optimum state, pharmaceutical formulation described in the such scheme also comprises following component and parts by weight content:
Adjuvant: Caulis Sargentodoxae (another name: 20～30 parts of Caulis Sargentodoxae) 80～120 parts, Myrrha;
Restriction medicine: 80～120 parts of Radix Angelicae Sinensis;
Guiding drug: 20～30 parts of Radix Achyranthis Bidentataes.
2, in the such scheme, described substrate adopts thermosol type or silica gel type.
3, about the property of medicine analysis of pharmaceutical formulation of the present invention
According to theory of Chinese medical science: the principle of " kidney governing bones, give birth to marrow, synthetism is invigorated blood circulation earlier, and the stasis of blood goes new bone to give birth to " and the achievement of successive dynasties clinical experience and modern pharmacological research, the each component pharmacology of prescription and effect are as follows:
(1), principal agent (monarch drug):
Hippocampus is come from Tang's supplement to the Herbal, and is warm in nature, and salty in the mouth is gone into kidney channel, warming the kidney to invigorate YANG, improving inspiration by invigorating kidney-QI eliminating stagnation repercussive.Successive dynasties are used to control sexual impotence, dyspnea due to deficiency, the enuresis, far long-pending, recent studies, and the Hippocampus alcohol extract has estrogen-like effects to female mice, and male mice is had androgen-like action.
(2), adjuvant (ministerial drug):
Sanguis Draxonis comes from three state's Lei Gong's Treatise on Preparation and Broiling of Materia Medica, and is sweet, salty, flat, goes into the conscience warp, blood stasis dispelling, pain relieving, hemostasis, granulation promoting.Be successive dynasties traumatology key medicines, the effect of hemostasis promoting blood circulation to remove blood stasis, pain relieving, granulation promoting, closing in is arranged.Modern pharmacological research contains dracorubin, can impel erythrocyte to decompose, and the water logging agent has inhibitory action to the various skin pathomycete.
Catechu comes from Song's " book on Chinese herbal medicine is stated ", bitter, temperature, cool, go into the cardiopulmonary warp, heat clearing away is stopped blooding, is promoted the production of body fluid, for the successive dynasties are controlled the blood disorder key medicine: modern pharmacological research, this product contains catechotannin, cachou extract and Quercetin, convergence is arranged, hemostasis, bacteriostasis, the water logging agent can suppress common pathogenic dermatophytes, cachou extract can anticancer, and cachou extract mass-energy is promoted capillary resistance and histamine and antiinflammatory action is arranged.
Caulis Sargentodoxae (another name: Caulis Sargentodoxae), the Jiangsu and Zhejiang Provinces traditional herbal medicine, bitter, put down, go into liver, large intestine channel, dispel the wind, invigorate blood circulation, collateral dredging, insecticidal action, cure mainly traumatic injury, carbuncle, arthralgia pain, the modern pharmacological research emodin all has inhibitory action to staphylococcus aureus, group B streptococcus, micrococcus catarrhalis large intestine and bacillus pyocyaneus.
Olibanum, Myrrha go out Shanxi " Mingyi Bielu ", and acrid in the mouth, hardship, temperature are gone into the heart, liver, spleen channel, the pain relieving of function blood-activating and qi-promoting, and relaxing muscles and tendons and activating QI and blood in the collateral, detumescence, granulation promoting must medications for whole bone of successive dynasties, traumatology, surgery, cure mainly that injury and bone fracture, internal injury swell and ache, carbuncle.Modern pharmacological research: antibiotic, antiinflammatory, analgesic activity are arranged.
(3), restriction medicine (adjuvant drug):
Radix Angelicae Sinensis comes from Shennong's Herbal, enrich blood, nourish blood, invigorate blood circulation, blood stasis dispelling, for the successive dynasties invigorate blood circulation card must medication, modern pharmacological research all has the improvement effect to blood vessel, blood pressure and organ blood flow etc., can microcirculation improvement, blood vessel dilating is promoted blood flow.
Rhizoma Chuanxiong comes from Shennong's Herbal, and is hot, warm, goes into liver, gallbladder pericardium channel, blood-activating and qi-promoting, and wind-expelling pain-stopping, for the successive dynasties invigorate blood circulation and the pain relieving key medicine, modern pharmacological research has antithrombotic to form antiplatelet aggregative activity, and the energy blood vessel dilating increases the histiocyte blood flow.Fracture absorption of hematoma and callus formation there is obvious facilitation.
(4), guiding drug (messenger drug):
Moschus, ancient Chinese medicine doctor all with this product logical close for having one's ideas straightened out, refreshment analepsia key medicine, it is scurried, and the power of loosing is strong, the effect of pain relieving dissipating blood stasis is on all medicines, modern pharmacological research this product has antithrombotic to form, antibiotic, antiinflammatory, the anti-effect of swelling and ache and increasing immunocompetence.
Borneolum Syntheticum, ancient Chinese medicine doctor are classified as to have one's ideas straightened out to lead to and are closed the eliminating stasis to stop pain key medicine.Modern pharmacological research can be expanded pore, blood vessel, microcirculation improvement, anti-inflammation, detumescence, analgesic effect.
Radix Achyranthis Bidentatae comes from Shennong's Herbal, and kidney channel is gone in bitter in the mouth, acid, flat, and the successive dynasties are strengthening bone and muscle, the kidney invigorating, promoting the circulation of blood, go into will cutting of kidney, and the merit of removing blood stasis blood, qualcomm meridian, invigorating the liver and kidney is arranged.Modern pharmacological research has the release of the histamine of promotion, blood vessel dilating, excited smooth muscle, analgesia, the effect of releasing spasm to vascular system.
4, separate about bone-setting pain-stopping plaster side of the present invention
Bone-setting pain-stopping plaster is to cure mainly fracture, traumatic injury, knife injury, injury of the bone section, surgery disease that neck shoulder, waist kneecap arthralgia and ulcer do not close up for a long time.
Hippocampus in the side is monarch, helps with Caulis Sargentodoxae, Sanguis Draxonis, Olibanum, Myrrha, Rhizoma Chuanxiong, Radix Angelicae Sinensis, makes it promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, promote organization of hematoma, make erythrocyte, tunica intima regeneration, osteoblast is active, and mineral such as the required calcium of callus formation obtain replenishing rapidly.Simultaneously, under the effect of Radix Angelicae Sinensis, Rhizoma Chuanxiong, can prevent over-drastic removing blood stasis dissipating blood stasis again, common composition can promoting blood circulation to remove blood stasis, and long bone can nourish blood again.Strengthen spasmolysis with catechu, Moschus, Borneolum Syntheticum, Radix Achyranthis Bidentatae, vascular smooth muscle relaxation and microcirculation improve, the histiocyte improving blood flow, absorption of hematoma, organize metabolism to quicken, the inflammation of congested (or containing antibacterial) is suppressed, the cartilage neovascularity regeneration of osteoarthritis, and muscular spasm is alleviated and an obvious analgesic effect.
Above-mentioned drug effect, Moschus, Borneolum Syntheticum to the dilatancy of pore, blood capillary, permeability effect under, enter blood circulation, tissue absorption rapidly, drug effect is not fully exerted, therefore, make the fracture and injury tissue repair fast, growth of spur is fast, granulation promoting, closing in, relaxing muscles and tendons and activating QI and blood in the collateral, analgesic effect is strong, the cicatrix effect of dispelling in addition simultaneously.
5, about Study on Preparation of the present invention
In order to guarantee and keep the curative effect of medicine, according to the characteristics of external cream, strengthen the control of production process, ensure drug quality, we study extraction process, preparations shaping technology.
(1), in conjunction with producing practical situation, the medical material of 0.1 recipe quantity is adopted in this experimental study, every part is that 1 gram (removes Moschus, outside the Borneolum Syntheticum, the common 390g of all the other 9 flavor medical materials) carrying out percolation extracts research, but it is for referencial use to be aided with commercial production reality operational circumstances and energy resource consumption, with the dry extract amount serves as to investigate index, and the orthogonal test of flow velocity (12ml/min, 16ml/min, 20ml/min) three factors three levels of soak time (6 hours, 8 hours, 12 hours), 90% consumption of ethanol (6 times of amounts, 8 times of amounts, 12 times of amounts) and percolation is investigated during to extraction.According to the result of experimental study, determined that extraction process adopts immersion 12 hours, the ethanol of 8 times of amounts 90%, percolation speed is the percolation condition of 16ml/min as this test.
(2), this test under the stable condition of percolation extraction process, the proportioning of substrate and extractum has been carried out further research.In the proportion research process, test as the reference index with mastic cohesiveness and cream sheet peel strength, in the hope of the rational proportion of this product substrate amount and extractum amount.Result of the test shows, the ratio of substrate and extractum be carry out at 4.5: 1 compatibility sample after quickening to stablize 3 months the sample peel strength with take off the cream phenomenon and all do not have significant difference, illustrate that the proportioning combination with 4.5: 1 is comparatively stable in this observation period, at this moment every 100cm
2Paste containing amount is greater than 1.9g (every is equivalent to crude drug amount 4.05g).
6, about skin acute toxicity test of the present invention
After rabbit intact skin group and damaged skin group are smeared bone-setting pain-stopping plaster 1g/kg and 3g/kg, observed animal coating position on the 2nd day, low, the high dose group of intact skin and damaged skin is low, high dose group does not find that all skin has symptoms such as erythema, edema, petechia, pachylosis or epidermatic atrophy as a result, do not see that the weight of animals, skin and hair, eye and mucosa etc. have ANOMALOUS VARIATIONS yet, the mental status of animal, extremity are movable normal, none death of animal.Animal stays examines seven days, and also no abnormality seen changes.Dissect the animal main organs, do not see that macroscopic pathologic changes, the skin biopsy microscopy does not see that change in a organized way.This shows that bone-setting pain-stopping plaster is not seen dermal toxicity, have safety preferably.Specifically see Appendix 1: " experiment of animal acute dermal toxicity " (totally 3 pages).
7, about specific safety test of the present invention
According to the external characteristic of bone-setting pain-stopping plaster, this test has been carried out skin irritation and skin anaphylactic test research to bone-setting pain-stopping plaster, and the result is as follows:
Only Cavia porcellus is carried out sensitization test (STT) with bone-setting pain-stopping plaster 0.2g/, do not see that animal skin has erythema, edema or systemic anaphylaxis in 72 hours after being tried to distinguish self administration of medication and exciting, skin allergy degree scoring score value is 0, and the sensitization of skin incidence rate is 0.Therefore, bone-setting pain-stopping plaster does not have anaphylactic reaction to guinea pig skin.
Rabbit coating 1g removed medicine after 24 hours, observed 7 days, and perusal every day intact skin group and damaged skin treated animal are smeared the position and had or not ANOMALOUS VARIATIONS such as erythema, edema, pigmentation, petechia, pachylosis or epidermatic atrophy.Observed result: the coating position of intact skin group and damaged skin group is irritative responses such as show speckle, edema not.Relatively there is not significant difference with the check plot.By skin irritation intensity evaluation standard, the mean scores of intact skin group is 0.The mean scores of damaged skin group is 0, so the bone-setting pain-stopping plaster single-dose is to the skin nonirritant.
8, about study on the stability of the present invention
According to Chinese Pharmacopoeia version " medicine stability test guideline " in 2000, three batches of bone-setting pain-stopping plasters (041001,041002,041003) are carried out stability test under the room temperature condition of 6 months accelerated test and 6 months.Accelerated stability test and room temperature stability test as a result shows, no significant change before and after every test item in experiment periods, and the bone-setting pain-stopping plaster quality is basicly stable, and now will fix tentatively effect duration is 2 years.
9, promote the union of fracture zoopery about the present invention
Through common through 12 of dogs, about 15 kilograms of body weight.Adopt freely falling body ground method to make the closed fracture model.Divide three groups to experimentize respectively, X sheet selective examination is taken the photograph in administration 21 days weekly, according to the orthopaedics healing standard rating rank that heals.The result shows that bone-setting pain-stopping plaster of the present invention is that the growth of external callus in the remarkable promotion comminuted fracture end and the effect of accelerating union of bone fracture are arranged.Seen that growth of spur passes through fracture line during three weeks.Has significant difference with positive controls through X ± SP check.Specifically see Appendix 2: " novel speed is answered and promoted the union of fracture experiment for JIEGU GAO II number " (totally 4 pages).
10, about clinical trial of the present invention
Report and sum up 20 routine experiences through clinical early stage application 42 examples, all confirm after bone-setting pain-stopping plaster of the present invention is used fresh fracture to be had good analgesic effect, medication was a pain relief after 2 hours, swelling is eliminated fast, basic detumescence in general 72 hours, promote fracture more time ratio normally fracture month and standard time shortening 1/2 to 2/3.Whole healings also have the remarkable result that promotes union of fracture to old fracture.Specifically see Appendix 3: " various fracture 20 examples of Chinese medicine " JIEGU GAO " treatment are summed up " (totally 4 pages); Adnexa 4: " the intractable fracture 42 example reports of Chinese medicine " JIEGU GAO " treatment " (totally 5 pages).
11, function of the present invention cures mainly
Bone-setting pain-stopping plaster of the present invention has promoting blood circulation to remove obstruction in the collateral, reducing swelling and alleviating pain, and continuous muscle bone growth promoting, the blood stasis dispelling effect of dispeling the wind is used for traumatic injury, injury of tendon and muscle fracture, blood stasis congelation, lumbar sprain and QI divergeny, wind and cold disease such as swell and ache.Cure mainly various light tissue injurys, muscular strain, whole body each position fracture and joint injury, diseases such as scapulohumeral periarthritis, cervical spondylosis, prolapse of lumbar intervertebral disc, sciatica, pathogenic wind-warm arthritis.
Behind this plaster external application fracture and the disease location, can reach pain relief in 30 minutes aftersensations warm-heat effect to medicine, limbs joint is flexibly movable, and the detumescence of swelling limbs soon.Occur fracture site callus bone growth promoting after 2～3 weeks, fracture end periphery callus is few, and union of fracture is fast and strong, and is evident in efficacy to the various damages of achievement property fracture, to whole body and local skin nonirritant and toxic action.
Description of drawings
Accompanying drawing 1 is preparation process Chinese medicine extraction process flow chart of the present invention;
Accompanying drawing 2 is preparation process mesostroma process chart of the present invention;
Accompanying drawing 3 is coating process flow chart in the preparation process of the present invention.
The specific embodiment
Below in conjunction with drawings and Examples the present invention is further described:
Embodiment one: a kind of bone-setting pain-stopping plaster
1, pharmaceutical formulation is made up of following component and parts by weight content:
Principal agent: 0 part of hippocampus 3;
Adjuvant: 50 parts of Sanguis Draxonis, 20 parts in catechu, 20 parts of Olibanums, 100 parts of Caulis Sargentodoxaes, 25 parts of Myrrhas;
Restriction medicine: 20 parts of Rhizoma Chuanxiongs, 100 parts of Radix Angelicae Sinensis;
Guiding drug: 5 parts in Moschus, 10 parts of Borneolum Syntheticums, 25 parts of Radix Achyranthis Bidentataes.
Above parts by weight are every part 10 gram, ten simply medical material amount to 4050 grams.
2, substrate adopts thermosol, and the substrate technological process is seen shown in Figure 2.
3, preparation method
(1), referring to shown in Figure 1, take by weighing the medical material (ten simply, altogether 4050g) of 1 recipe quantity, remove Moschus, outside the Borneolum Syntheticum, 9 flavors such as all the other Hippocampus totally 3900 grams are ground into coarse powder (16 mesh sieve), according to percolation under fluid extract and the extractum item, make solvent with 90% ethanol of 8 times of amounts, flood after 12 hours, carry out percolation (percolation speed is 16ml/min), collect percolate, being concentrated into relative density is the extractum (44.15g) of 1.20～1.25 (70 ℃).
(2), referring to shown in Figure 3, be that 4.5: 1 ratios are got the substrate 198.68g that adjuvant such as medical hot melt glue PM-2C is made in substrate and extractum, this moment every 100cm
2Paste containing amount adds above-mentioned extractum and Moschus and Borneolum Syntheticum two flavors greater than 1.9g (every is equivalent to crude drug amount 4.05g), stirs evenly, and is coated with cream, the lid lining, and itemize, section is made 1000, promptly.
Embodiment two: a kind of bone-setting pain-stopping plaster
1, pharmaceutical formulation is made up of following component and parts by weight content:
Principal agent: 24 parts of Hippocampus;
Adjuvant: 40 parts of Sanguis Draxonis, 16 parts in catechu, 16 parts of Olibanums, 80 parts of Caulis Sargentodoxaes, 20 parts of Myrrhas;
Restriction medicine: 16 parts of Rhizoma Chuanxiongs, 80 parts of Radix Angelicae Sinensis;
Guiding drug: 4 parts in Moschus, 8 parts of Borneolum Syntheticums, 20 parts of Radix Achyranthis Bidentataes.
Above parts by weight are every part 10 gram, ten simply medical material amount to 3240 grams.
2, substrate adopts thermosol, and the substrate technological process is seen shown in Figure 2.
3, preparation method is identical with embodiment one, no longer is repeated in this description here.
Embodiment three: a kind of bone-setting pain-stopping plaster
1, pharmaceutical formulation is made up of following component and parts by weight content:
Principal agent: 6 parts of hippocampus 3s;
Adjuvant: 60 parts of Sanguis Draxonis, 24 parts in catechu, 24 parts of Olibanums, 120 parts of Caulis Sargentodoxaes, 30 parts of Myrrhas;
Restriction medicine: 24 parts of Rhizoma Chuanxiongs, 120 parts of Radix Angelicae Sinensis;
Guiding drug: 6 parts in Moschus, 12 parts of Borneolum Syntheticums, 30 parts of Radix Achyranthis Bidentataes.
Above parts by weight are every part 10 gram, ten simply medical material amount to 4860 grams.
2, substrate adopts thermosol, and the substrate technological process is seen shown in Figure 2.
3, preparation method is identical with embodiment one, no longer is repeated in this description here.
The foregoing description only is explanation technical conceive of the present invention and characteristics, and its purpose is to allow the personage who is familiar with this technology can understand content of the present invention and enforcement according to this, can not limit protection scope of the present invention with this.All equivalences that spirit is done according to the present invention change or modify, and all should be encompassed within protection scope of the present invention.
Claims (2)
1, a kind of bone-setting pain-stopping plaster, is fully mixed with substrate after pulverizing, extract, concentrating by pharmaceutical formulation, is coated with, section and molding is characterized in that again: described pharmaceutical formulation comprises following component and parts by weight content:
Principal agent: 24～36 parts of Hippocampus;
Adjuvant: 40～60 parts of Sanguis Draxonis, 16～24 parts in catechu, 16～24 parts of Olibanums;
Restriction medicine: 16～24 parts of Rhizoma Chuanxiongs;
Guiding drug: 4～6 parts in Moschus, 8～12 parts of Borneolum Syntheticums.
2, bone-setting pain-stopping plaster according to claim 1 is characterized in that: also comprise following component and parts by weight content in the described pharmaceutical formulation:
Adjuvant: 80～120 parts of Caulis Sargentodoxaes, 20～30 parts of Myrrhas;
Restriction medicine: 80～120 parts of Radix Angelicae Sinensis;
Guiding drug: 20～30 parts of Radix Achyranthis Bidentataes.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100405066A CN100349593C (en) | 2005-06-09 | 2005-06-09 | Bone-setting pain-stopping plaster |
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| CNB2005100405066A CN100349593C (en) | 2005-06-09 | 2005-06-09 | Bone-setting pain-stopping plaster |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547085A (en) * | 2015-01-19 | 2015-04-29 | 张芳 | Plaster with functions of dredging collaterals, expelling stasis and promoting bone growth and preparation method thereof |
| CN107224448A (en) * | 2017-06-27 | 2017-10-03 | 李豹 | A kind of external-applied ointment for treating traumatic injury |
| CN107998179A (en) * | 2017-12-25 | 2018-05-08 | 王祯萍 | Medicine rod for fiery sunburn treatment method is processed presses wine solution with fire |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1205959C (en) * | 2002-12-14 | 2005-06-15 | 袁锐三 | Plaster |
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2005
- 2005-06-09 CN CNB2005100405066A patent/CN100349593C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547085A (en) * | 2015-01-19 | 2015-04-29 | 张芳 | Plaster with functions of dredging collaterals, expelling stasis and promoting bone growth and preparation method thereof |
| CN107224448A (en) * | 2017-06-27 | 2017-10-03 | 李豹 | A kind of external-applied ointment for treating traumatic injury |
| CN107998179A (en) * | 2017-12-25 | 2018-05-08 | 王祯萍 | Medicine rod for fiery sunburn treatment method is processed presses wine solution with fire |
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| Publication number | Publication date |
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| CN100349593C (en) | 2007-11-21 |
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