CN1709307A

CN1709307A - Method for preparing particle formulation for treating psoriasis

Info

Publication number: CN1709307A
Application number: CNA2005100100848A
Authority: CN
Inventors: 郝大平
Original assignee: HARBIN DAYANG PHARMACEUTICAL CO Ltd
Current assignee: HARBIN DAYANG PHARMACEUTICAL CO Ltd
Priority date: 2005-06-15
Filing date: 2005-06-15
Publication date: 2005-12-21
Anticipated expiration: 2025-06-15
Also published as: CN100388937C

Abstract

The present invention relates to a Chinese medicine granules preparation for effectively curing psoriasis. Said Chinese medicine granules preparation is made up by using 12 Chinese medicinal materials of flavescent sophora root, licorice, dictamnus root bark, ledebouriella root, smooth greenbrier root, cicada molting and others. Besides, said invention also provides its preparation method and concrete steps.

Description

The preparation method of treatment psoriasis granule

Technical field: the present invention relates to treat psoriatic medicine, be specially a kind of preparation method for the treatment of the psoriasis granule.

Background technology: the domestic particulate product of Etretinate of not producing at present.The domestic product that has only Etretinate (soft extract) at present.Problem and shortcoming that dosage form exists: the employed adjuvant of soft extract is refined honey or sugar (or Nulomoline), because the storage cycle of the character of adjuvant decision Etretinate (soft extract) is short, dose is big, be not easy to carry etc., and cause the patient who suffers from diabetes simultaneously to use because contain a large amount of sugar.Problem and shortcoming that production technology exists: the production technology of Etretinate (soft extract) be group's medicine heating extraction, concentrate and refined honey or sugar (or Nulomoline) Hybrid Heating is concentrated, filling bottle.This technology causes Chinese crude drug to be in for a long time under the condition of high temperature, and effective ingredient destroys bigger; Some do not have physiologically active ingredient to be extracted in a large number yet simultaneously, cause dose to increase.Do not control the measure of its quality situation in Etretinate (soft extract) standard.

Summary of the invention: the object of the present invention is to provide a kind of compatibility simple, with low cost, safe and reliable, easy to use, at normal temperatures the preparation method of the treatment psoriasis granule of Bao Cuning.The object of the present invention is achieved like this: it comprises Radix Sophorae Flavescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Saposhnikoviae, Rhizoma Smilacis Glabrae, Periostracum Cicadae, Cortex Phellodendri, Radix Rehmanniae, Flos Lonicerae, Radix Paeoniae Rubra, Fructus Forsythiae, Radix Angelicae Sinensis.Radix Sophorae Flavescentis 60g, Radix Glycyrrhizae 60g, Cortex Dictamni 80g, Radix Saposhnikoviae 60g, Rhizoma Smilacis Glabrae 120g, Periostracum Cicadae 80g, Cortex Phellodendri 40g, Radix Rehmanniae 80g, Flos Lonicerae 80g, Radix Paeoniae Rubra 40g, Fructus Forsythiae 60g, Radix Angelicae Sinensis 60g.Flos Lonicerae, Fructus Forsythiae, Radix Saposhnikoviae, Periostracum Cicadae are decocted with water secondary with multi-function extractor, the water that at every turn adds 10 times of medical material amounts, pick up counting from boiling decocted 1 hour at every turn, and each decoction liquor filters with two layer of 300 order silk one deck absorbent cotton, it is stand-by that merging filtrate, medicinal liquid are stored in stainless steel storage tank; Eight flavors such as all the other Radix Sophorae Flavescentiss, decoct with water three times, the water that at every turn adds 10 times of medical material amounts, pick up counting from boiling decocted 1 hour at every turn, and each decoction liquor filters merging filtrate with two layer of 300 order silk one deck absorbent cotton, merge with the medicinal liquids of 4 flavor medicines such as Flos Lonicerae, with the energy-conservation concentrator concentrating under reduced pressure of economic benefits and social benefits, 75 ± 2 ℃ of temperature controls, being concentrated into relative density is the clear paste of 1.23 (60～65 ℃ of heat are surveyed); Cane sugar powder is broken to 80 orders, and dextrin is crossed 80 mesh sieves, the sucrose adding mixer of clear paste amount doubling dose is added again the dextrin of clear paste amount doubling dose, mixed 10 minutes, under the situation of not stopping mixer, add clear paste and be mixed with soft material, make to reach hold agglomerating, touch the state that promptly looses, stop to mix; The soft material for preparing is joined in the 16 purpose granulator; feeding quantity is no more than 2/3 of granulator hopper; make granule, with wet grain drying, temperature is controlled at 80 ℃; dry 20 minutes; granule by upper strata 12 layer 40 purpose pelletizing machine granulate now, drops into granule three-dimensional motion mixer again and always mixed 20 minutes again, and granule is with the packing of full-automatic granule racking machine afterwards; every bag of packing 10 grams (or 20 grams), packing promptly.Advantage of the present invention is: simple, with low cost, safe and reliable, easy to use, the preservation at normal temperatures of compatibility is easy to carry about with one.

The specific embodiment: it comprises Radix Sophorae Flavescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Saposhnikoviae, Rhizoma Smilacis Glabrae, Periostracum Cicadae, Cortex Phellodendri, Radix Rehmanniae, Flos Lonicerae, Radix Paeoniae Rubra, Fructus Forsythiae, Radix Angelicae Sinensis.Radix Sophorae Flavescentis 60g, Radix Glycyrrhizae 60g, Cortex Dictamni 80g, Radix Saposhnikoviae 60g, Rhizoma Smilacis Glabrae 120g, Periostracum Cicadae 80g, Cortex Phellodendri 40g, Radix Rehmanniae 80g, Flos Lonicerae 80g, Radix Paeoniae Rubra 40g, Fructus Forsythiae 60g, Radix Angelicae Sinensis 60g.Flos Lonicerae, Fructus Forsythiae, Radix Saposhnikoviae, Periostracum Cicadae are decocted with water secondary with multi-function extractor, the water that at every turn adds 10 times of medical material amounts, pick up counting from boiling decocted 1 hour at every turn, and each decoction liquor filters with two layer of 300 order silk one deck absorbent cotton, it is stand-by that merging filtrate, medicinal liquid are stored in stainless steel storage tank; Eight flavors such as all the other Radix Sophorae Flavescentiss, decoct with water three times, the water that at every turn adds 10 times of medical material amounts, pick up counting from boiling decocted 1 hour at every turn, and each decoction liquor filters merging filtrate with two layer of 300 order silk one deck absorbent cotton, merge with the medicinal liquids of 4 flavor medicines such as Flos Lonicerae, with the energy-conservation concentrator concentrating under reduced pressure of economic benefits and social benefits, 75 ± 2 ℃ of temperature controls, being concentrated into relative density is the clear paste of 1.23 (60～65 ℃ of heat are surveyed); Cane sugar powder is broken to 80 orders, and dextrin is crossed 80 mesh sieves, the sucrose adding mixer of clear paste amount doubling dose is added again the dextrin of clear paste amount doubling dose, mixed 10 minutes, under the situation of not stopping mixer, add clear paste and be mixed with soft material, make to reach hold agglomerating, touch the state that promptly looses, stop to mix; The soft material for preparing is joined in the 16 purpose granulator; feeding quantity is no more than 2/3 of granulator hopper; make granule, with wet grain drying, temperature is controlled at 80 ℃; dry 20 minutes; granule by upper strata 12 layer 40 purpose pelletizing machine granulate now, drops into granule three-dimensional motion mixer again and always mixed 20 minutes again, and granule is with the packing of full-automatic granule racking machine afterwards; every bag of packing 10 grams (or 20 grams), packing promptly.[function with cure mainly] dispeiling pathogenic wind and removing dampness, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling.Be used for psoriasis.Usage and consumption: boiled water is taken after mixing it with water, each 20 grams, or follow the doctor's advice 2 times on the one.The careful usefulness of [taboo] anemia of pregnant woman.[points for attention] diet irritable food.[specification] every packed 20 grams.[storage] sealing.

Claims

1, a kind of preparation method for the treatment of psoriatic granule, it comprises Radix Sophorae Flavescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Saposhnikoviae, Rhizoma Smilacis Glabrae, Periostracum Cicadae, Cortex Phellodendri, Radix Rehmanniae, Flos Lonicerae, Radix Paeoniae Rubra, Fructus Forsythiae, Radix Angelicae Sinensis, it is characterized in that: Radix Sophorae Flavescentis 60g, Radix Glycyrrhizae 60g, Cortex Dictamni 80g, Radix Saposhnikoviae 60g, Rhizoma Smilacis Glabrae 120g, Periostracum Cicadae 80g, Cortex Phellodendri 40g, Radix Rehmanniae 80g, Flos Lonicerae 80g, Radix Paeoniae Rubra 40g, Fructus Forsythiae 60g, Radix Angelicae Sinensis 60g; Flos Lonicerae, Fructus Forsythiae, Radix Saposhnikoviae, Periostracum Cicadae are decocted with water secondary with multi-function extractor, the water that at every turn adds 10 times of medical material amounts, pick up counting from boiling decocted 1 hour at every turn, and each decoction liquor filters with two layer of 300 order silk one deck absorbent cotton, it is stand-by that merging filtrate, medicinal liquid are stored in stainless steel storage tank; Eight flavors such as all the other Radix Sophorae Flavescentiss, decoct with water three times, the water that at every turn adds 10 times of medical material amounts, pick up counting from boiling decocted 1 hour at every turn, and each decoction liquor filters merging filtrate with two layer of 300 order silk one deck absorbent cotton, merge with the medicinal liquids of 4 flavor medicines such as Flos Lonicerae, with the energy-conservation concentrator concentrating under reduced pressure of economic benefits and social benefits, 75 ± 2 ℃ of temperature controls, being concentrated into relative density is the clear paste of 1.23 (60～65 ℃ of heat are surveyed); Cane sugar powder is broken to 80 orders, and dextrin is crossed 80 mesh sieves, the sucrose adding mixer of clear paste amount doubling dose is added again the dextrin of clear paste amount doubling dose, mixed 10 minutes, under the situation of not stopping mixer, add clear paste and be mixed with soft material, make to reach hold agglomerating, touch the state that promptly looses, stop to mix; The soft material for preparing is joined in the 16 purpose granulator; feeding quantity is no more than 2/3 of granulator hopper; make granule, with wet grain drying, temperature is controlled at 80 ℃; dry 20 minutes; granule by upper strata 12 layer 40 purpose pelletizing machine granulate now, drops into granule three-dimensional motion mixer again and always mixed 20 minutes again, and granule is with the packing of full-automatic granule racking machine afterwards; every bag of packing 10 grams (or 20 grams), packing promptly.