CN1706400A - Application of stomach inclusion of sucking river deer in preparing medicine - Google Patents
Application of stomach inclusion of sucking river deer in preparing medicine Download PDFInfo
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- CN1706400A CN1706400A CNA2004100250959A CN200410025095A CN1706400A CN 1706400 A CN1706400 A CN 1706400A CN A2004100250959 A CNA2004100250959 A CN A2004100250959A CN 200410025095 A CN200410025095 A CN 200410025095A CN 1706400 A CN1706400 A CN 1706400A
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Abstract
The present invention provides the application of stomach inclusion of sucking river deer in preparing medicine for indigestion. The present invention also provides the application of stomach inclusion of sucking river deer in preparing medicine for increasing gastric motive force. The present invention provides further the application of stomach inclusion of sucking river deer in preparing medicine for promoting the secretion of digestive enzyme system in stomach.
Description
Invention field
The present invention relates to the application of Hydropotes inermis Swinhoe gastric contents in the preparation medicine.Specifically, the present invention relates to Hydropotes inermis Swinhoe gastric contents and promote that in preparation gastric motility and facilitating digestion enzyme are the application of excretory medicine.
Background of invention
River deer (Hydropotes inermis swinhoe) has another name called river deer, is a kind of animal in deer family, belongs to national secondary and lays special stress on protecting animal.Of the present invention researching and analysing raised and train the breed river deer that breeds more than the three generations to liking.
The breast river deer can form Off-white solid or semi-solid block after sucking river deer milk under one's belt.Because river deer is difficult to large-scale farming, so seldom there is associated research to be disclosed report.There is not the report relevant in the prior art with the application of Hydropotes inermis Swinhoe gastric contents yet.
Summary of the invention
An object of the present invention is to provide the application of Hydropotes inermis Swinhoe gastric contents in the preparation medicine.
The present invention relates to the application of Hydropotes inermis Swinhoe gastric contents in the medicine of preparation treatment indigestion.
The invention still further relates to the application of Hydropotes inermis Swinhoe gastric contents in the medicine of preparation increase gastric motility.
The invention further relates to Hydropotes inermis Swinhoe gastric contents and promote that in preparation the peptic digestion enzyme is the application in the excretory medicine.
Described indigestion is hyposecretion or is caused jointly by both by gastric dynamic dysfunction or by digestive enzyme.
Described Hydropotes inermis Swinhoe gastric contents is all taken from and is raised and train the above newborn river deer of breeding three generations.After the breast river deer sucks river deer milk, at stomach, the Off-white solid or the semi-solid block that can form in the abomasum (glandular stomach) particularly, Hydropotes inermis Swinhoe gastric contents of the present invention all refers in particular to this block.
At present, through a large amount of experimental analysiss, the Hydropotes inermis Swinhoe gastric contents protein content is very high, contains the necessary aminoacid of multiple human body simultaneously.The result of inorganic microelement analysis shows, wherein the macroelement that needs of human body and the Fe in the trace element, P, Ca, Mn equal size are all higher.
In one embodiment of the invention, can obtain Hydropotes inermis Swinhoe gastric contents by following live body extraction step:
1. with newborn river deer anesthesia sterilization;
2. carry out the live body operation, cut the abomasum (glandular stomach) of river deer open, take out Off-white solid or semi-solid block;
3. after the operation, give newborn river deer suitable infection measure.
Relevant experiment and tracing observation result thereof show that this operation does not have influence to the normal growth of newborn river deer, and growth promoter of the newborn river deer in operation back and reproduction procreation all do not have significant difference with the newborn river deer of underwent operative not.Simultaneously, adopt anesthesia surgery can exempt the misery of newborn river deer.
Description of drawings
Fig. 1 has shown among the pharmacology embodiment oral Hydropotes inermis Swinhoe gastric contents rat small intestine propelling rate after 3 days
Fig. 2 has shown among the pharmacology embodiment oral Hydropotes inermis Swinhoe gastric contents rat stomach methyl orange residual rate after 3 days.
The specific embodiment
Feedstock production embodiment:
The newborn river deer (numbering 1139) of one 12 age in days is manually awarded with the river deer breast.After three hours, lump can be touched in this breast river deer glandular stomach position.Should after sterilization, bring aseptic operating room into by the breast river deer, be fixed on the operating-table.After its anesthesia, its abdominal part is cut in operation open, finds glandular stomach (along the 4th stomach under the esophagus), after it is cut open, takes out the milky block.Close wound, sew up, and give the antibiotic prophylaxis infection.The Hydropotes inermis Swinhoe gastric contents dehydration back of gained is standby.
Pharmacology embodiment
Choosing SD is rat, is regular grade, closed colony, body weight 200-250g, random packet, male and female half and half (being provided by China and Britain's joint Shanghai BK laboratory animal company limited).
If blank group (with the volume normal saline), positive controls (motilium group, dosage are 3.6mg/kg/ time), Hydropotes inermis Swinhoe gastric contents various dose group.Test group Chinese medicine, motilium matched group are according to the corresponding solubility of above-mentioned each medicine of following administration volume settings, and rat 1.5ml/100g adopts gastric infusion, every day 2 times, serve on 3 days.
(1) stomach function test:
1, emptying test: behind the rat oral gavage administration 3d, 2h after last 1 administration, gavage 0.2ml 0.1% methyl orange (the fasting 12h of rat elder generation before the administration), to 20min after the methyl orange, animal is put to death in dislocation, cuts open the belly and gets stomach, stomach is placed disposable urine cup, add the 10ml distilled water and whet the appetite along greater gastric curvature, gastric content is fully washed in distilled water, use NaHCO with little shears
3Liquid is transferred PH6.0-6.5, the centrifugal 10min of 2000tpm gets supernatant and surveys in the 420nm place and respectively manage trap, distilled water zeroising, and add the 10ml distilled water with 0.1% methyl orange 0.2ml and shake up the back and survey trap as radix methyl orange optical density, and be calculated as follows methyl orange stomach residual rate:
Methyl orange stomach residual rate (%)=stomach methyl orange optical density/radix methyl orange optical density * 100%
2, gastric analysis:
The mensuration of a, gastric juice amount, gastric acidity:
Rat fasting (can't help water) after administration in the 1st day, after the administration 3 days, with ether with Animal Anesthesia, open the abdominal cavity, ligation pylorus, 5 hours rat gastric juice behind the collection pylorus ligation, with 2000tpm centrifugal about 5 minutes, remove gastric contents such as food debris,, measure the acidity of gastric juice with pH meter with the suitable accurate weighing gastric juice of the graduated cylinder amount of capacity.
B, free acid and titration of total acidity:
Measure gastric juice 5ml, place conical flask to add equivalent distilled water, mix homogeneously.Add each 2 of free acid indicator and total acid indicators, if contain hydrochloric acid, promptly be cherry red in the mixing gastric juice.Drip 0.1mol/LNaOH with burette, limit edged shaking flasks disappears to red, begins to occur to be the terminal point of free hydrochloric acid till the crocus, and record spends the milliliter number of NaOH solution.Till continuation dropping 0.1mol/LNaOH no longer deepens to redness, be the terminal point of total acidity, write down twice titration and spend NaOH solution total amount.
Calculate: 0.1mol/LNaOH milliliter number * (100ml gastric juice/gastric juice actual amount 5ml)=gastric juice mmol/L, total secretory volume=gastric juice amount * acidity
C, determination of peptic activity:
1, adopts the capillary tube method of Mai Te, with the capillary glass of internal diameter 1-2mm even thickness
Pipe is cut into clean the drying of length of 10cm.Get an amount of Ovum Gallus domesticus album and fully beat even back and use filtered through gauze, above-mentioned glass capillary is utilized siphonage, fill Ovum Gallus domesticus album (manage planted agent do not have bubble sneak into).Be positioned over then in 85 ℃ of vapourss and make protein coagulating.After cooling, taking-up with the sealing of protein pipe two ends, is store in the refrigerator standby with paraffin.Get the conical flask that gastric juice 1ml puts into 50ml during experiment, add 0.05N hydrochloric acid solution 15ml, shake up, put two of long approximately 2cm protein pipe into.Filled in bottleneck, be put in 37 ℃ of calorstats temperature and incubated 24 hours.Measure the length (mm) of protein pipe two ends transparent part with chi and ask its meansigma methods with the value of four ends.
Pepsic unit=meansigma methods
2* 16
The gastric juice amount of pepsin activity (IU/h)=pepsin unit * per hour
(2) intestinal propulsion exercise test:
Rat fasting (can't help water) after administration in the 3rd day, the last corresponding medicine that contains 10% active carbon of giving, 20min puts to death the mice dissection and takes out small intestinal after giving active carbon, lies in the absorbent paper, measure small intestinal total length and pylorus to carbon powder distal-most end advance distance, and calculate the propelling percentage rate:
Advance percentage rate=(carbon powder advance distance/small intestinal total length) * 100%
(3) statistical method:
Pre-experimental data just adopts the computer software package statistics of SAS6.04 version, represents with mean ± standard deviation, and does variance analysis, p value＜0.05 expression significant difference.
The result
1, intestinal propulsion exercise test:
The administration of rat random packet, fasting after the administration in the 3rd day contains for the last time the corresponding medicine of 10% active carbon to clothes, and 20min cuts open the belly and gets small intestinal counting intestinal propulsion percentage rate and the results are shown in Table 1 and Fig. 1 after giving active carbon.It is as shown in the table, compares with the blank group, and Hydropotes inermis Swinhoe gastric contents 0.5mg/kg all has therapeutic effect for above group,
And be dose-effect relationship.Compare with the motilium group, Hydropotes inermis Swinhoe gastric contents 0.5mg/kg does not all have significant difference for above group, and prompting Hydropotes inermis Swinhoe gastric contents curative effect is suitable with motilium.
The oral Hydropotes inermis Swinhoe gastric contents of table 1 rat small intestine propelling rate after 3 days
| Group | ??X±S(％) | ??P |
| The blank group | ??64.3±7.80 | |
| The motilium group | ??83.7±8.85 | ??P＜0.01 |
| Hydropotes inermis Swinhoe gastric contents 30mg/kg | ??89.1±4.67 | ??P＜0.01 |
| Hydropotes inermis Swinhoe gastric contents 15mg/kg | ??86.1±3.0 | ??P＜0.01 |
| Hydropotes inermis Swinhoe gastric contents 7.5mg/kg | ??85.2±6.16 | ??P＜0.01 |
| Hydropotes inermis Swinhoe gastric contents 2.5mg/kg | ??84.3±10.09 | ??P＜0.01 |
| Hydropotes inermis Swinhoe gastric contents 1mg/kg | ??83.8±6.10 | ??P＜0.01 |
| Hydropotes inermis Swinhoe gastric contents 0.5mg/kg | ??83.2±10.47 | ??P＜0.05 |
| Hydropotes inermis Swinhoe gastric contents 0.25mg/kg | ??70.7±13.15 | ??P＞0.05 |
| Hydropotes inermis Swinhoe gastric contents 0.1mg/kg | ??69.9±7.97 | ??P＞0.05 |
| Hydropotes inermis Swinhoe gastric contents 0.05mg/kg | ??68.6±6.92 | ??P＞0.05 |
| Hydropotes inermis Swinhoe gastric contents 0.025mg/kg | ??65.2±4.16 | ??P＞0.05 |
| Hydropotes inermis Swinhoe gastric contents 0.0125mg/kg | ??64.2±11.15 | ??P＞0.05 |
| Hydropotes inermis Swinhoe gastric contents 0.00625mg/kg | ??63.0±3.36 | ??P＞0.05 |
The P value compares for each group and blank group
2, emptying test:
After the rat oral gavage administration 3 days, 2h after last 1 administration gavages methyl orange, cuts open the belly behind the 20min to get stomach and survey stomach methyl orange residual rate, the results are shown in Table 2 and Fig. 2.It is as shown in the table, compares with the blank group, and Hydropotes inermis Swinhoe gastric contents 0.1mg/kg all has therapeutic effect for above group.Compare with the motilium group, Hydropotes inermis Swinhoe gastric contents 0.1mg/kg does not all have significant difference for above group, and prompting Hydropotes inermis Swinhoe gastric contents curative effect is suitable with motilium.
The oral Hydropotes inermis Swinhoe gastric contents of table 2 rat stomach methyl orange residual rate after 3 days
| Group | ??X±S | ??P |
| The blank group | ??77.1±12.33 | |
| The motilium group | ??65.4±10.57 | ??P＞0.05 |
| Hydropotes inermis Swinhoe gastric contents 15mg/kg | ??49.4±13.73 | ??P＜0.05 |
| Hydropotes inermis Swinhoe gastric contents 1mg/kg | ??50.0±19.37 | ??P＜0.05 |
| Hydropotes inermis Swinhoe gastric contents 0.1mg/kg | ??54.1±9.77 | ??P＜0.05 |
| Hydropotes inermis Swinhoe gastric contents 0.00625mg/kg | ??76.5±5.92 | ??P＞0.05 |
The P value compares for each group and blank group
3, gastric analysis:
Shown in table 3,4,5, to compare with the blank group, 0.1mg/kg/ above group of Hydropotes inermis Swinhoe gastric contents has facilitation to pepsin activity.0.00625mg/kg/ above group of Hydropotes inermis Swinhoe gastric contents has facilitation to the secretion of total acid, but the secretion of free acid, gastric acidity, gastric juice amount is not had facilitation.The motilium group is to the no effect of secretion of total acidity, free acid, gastric acidity, gastric juice amount, and there were significant differences but the effect of pepsin activity compared with the blank group.
Table 3: pepsin activity behind the rat stomach pylorus ligation 5h
| Group | Pepsin (X ± SIU/h) | ??P |
| The blank group | ??414.1±25.74 | |
| The motilium group | ??623.3±41.29 | ??P＜0.01 |
| Hydropotes inermis Swinhoe gastric contents 15mg/kg | ??643.8±7.59 | ??P＜0.01 |
| Hydropotes inermis Swinhoe gastric contents 1mg/kg | ??642.0±61.4 | ??P＜0.01 |
| Hydropotes inermis Swinhoe gastric contents 0.1mg/kg | ??646.6±93.68 | ??P＜0.05 |
| Hydropotes inermis Swinhoe gastric contents 0.00625mg/kg | ??503.4±88.2 | ??P＞0.05 |
P compares for each group and blank group
Table 4 rat total acidity gastric juice, free acid
| Group | Total acidity (mmol/L) | Free acid (mmol/L) | ??P1 | ??P2 |
| Blank | ??55±5.0 | ??26±7.2 | ||
| Motilium | ??60.6±3.7 | ??34.9±1.5 | ??P＞0.05 | ??P＞0.05 |
| Hydropotes inermis Swinhoe gastric contents 15mg/kg | ??67±3.6 | ??37.7±3.9 | ??P＜0.05 | ??P＞0.05 |
| Hydropotes inermis Swinhoe gastric contents 1mg/kg | ??60.3±9.4 | ??35.7±15.3 | ??P＜0.05 | ??P＞0.05 |
| Hydropotes inermis Swinhoe gastric contents 0.1mg/kg | ??63.6±5.7 | ??36.4±11.5 | ??P＜0.05 | ??P＞0.05 |
| Hydropotes inermis Swinhoe gastric contents 0.00625mg/kg | ??64.6±3.5 | ??31.4±4.2 | ??P＜0.05 | ??P＞0.05 |
P1 is that each group of total acidity compares with the blank group
P2 is that each group of free acid compares with the blank group
Table 5 rat stomach liquid acidity, gastric juice amount
| Group | Gastric acidity | Gastric juice amount (ml) | ??P1 | ??P2 |
| Blank | ??1.74±0.14 | ??8.20±1.83 | ||
| Motilium | ??1.60±0.07 | ??13.18±3.93 | ??P＞0.05 | ??P＞0.05 |
| Hydropotes inermis Swinhoe gastric contents 15mg/kg | ??1.85±0.52 | ??7.2±2.33 | ??P＞0.05 | ??P＞0.05 |
| Hydropotes inermis Swinhoe gastric contents 1mg/kg | ??1.68±0.48 | ??8.93±2.12 | ??P＞0.05 | ??P＞0.05 |
| Hydropotes inermis Swinhoe gastric contents 0.1mg/kg | ??1.50±0.21 | ??11.63±3.50 | ??P＞0.05 | ??P＞0.05 |
| Hydropotes inermis Swinhoe gastric contents 0.00625mg/kg | ??1.54±0.19 | ??8.50±1.11 | ??P＞0.05 | ??P＞0.05 |
P1 is that each group of gastric acidity compares with the blank group
P2 is that each group of gastric juice amount compares with the blank group
From The above results as can be known, 0.1mg/kg/ above group of Hydropotes inermis Swinhoe gastric contents has the effect of certain accelerate gastric emptying, and 0.5mg/kg/ above group has intestinal propulsion and comparatively significantly adds fastoperation, illustrates that Hydropotes inermis Swinhoe gastric contents all has certain curative effect to gastrointestinal propulsion.
2, promote gastric acid, pepsinia gastric acid, pepsin to play a part positive to the digestion of food, the possible pathogenesis of food stagnation patient is exactly that gastric acid, pepsinia reduce, the active reduction causes food digestion bad, causes symptoms such as abdominal distention, stomachache.0.1mg/kg/ above group of Hydropotes inermis Swinhoe gastric contents has facilitation to pepsin activity in this experiment, and 0.00625mg/kg/ above group of Hydropotes inermis Swinhoe gastric contents has facilitation to the secretion of total acid.
Conclusion
1, after oral administration gave Hydropotes inermis Swinhoe gastric contents, rat stomach emptying, intestinal motility obviously increased.
2, behind the oral Hydropotes inermis Swinhoe gastric contents, rat total acidity gastric juice, pepsin activity increase, but free acid, gastric acidity, gastric juice amount increase not obvious.
3, the minimum effective dose of Hydropotes inermis Swinhoe gastric contents treatment food stagnation is 0.1-0.5mg/kg/ time.
4, compare with motilium group treatment food stagnation, gastric emptying, intestinal propulsion motion, pepsin activity no difference of science of statistics show that both act on quite.
5, this pre-experiment just finds that mechanism of action of Hydropotes inermis Swinhoe gastric contents treatment food stagnation may be by promoting gastric emptying, intestinal propulsion to move and realize, also may be by pepsinia is increased, thereby reach the effect of digest food.
Therefore, animal experiment studies show that Hydropotes inermis Swinhoe gastric contents has tangible promotion gastric motility and the facilitating digestion enzyme is excretory effect.Capsule prepares embodiment
With fresh Hydropotes inermis Swinhoe gastric contents 2Kg, behind 40 ℃ of vacuum dryings, add by actual Hydropotes inermis Swinhoe gastric contents weight after the lyophilization, 5% weight magnesium stearate is mixed breading, crosses the 40-60 eye mesh screen, makes granule.Dried granule is incapsulated specification: the 20mg/ grain.
Clinical implementation example one:
XXX, man, 42 years old.February in 2004, supper aftersensation on the 20th upper abdomen was glutted, had difficulty in going to sleep, and the lasting a few days of this symptom does not move back.Confirm through examination in hospital, because of gastric dynamic dysfunction causes dyspepsia.After taking the Hydropotes inermis Swinhoe gastric contents capsule that capsule prepares embodiment preparation (specification: 20mg/ grain, whenever take two after the meal), next day, symptom promptly alleviated, and faded away in five days.
Clinical implementation example two:
XX, woman, 53 years old.Retirement back is unhappy, and long-term anorexia causes health status obviously to descend, and the face yellowing, becomes thin.Through examination in hospital, be functional dyspepsia.Take Hydropotes inermis Swinhoe gastric contents capsule (specification: 20mg/ grain, every day three times, each two) that capsule prepares embodiment preparation after 7 days, symptom alleviates gradually, and appetite heightens, and is of pink and healthy-looking, and mental status is good.
Therefore, Hydropotes inermis Swinhoe gastric contents has the effect that promotes gastric motility and promote the peptic digestion enzyme secretion, can be used for preparing the medicine for the treatment of indigestion.
Claims (6)
1. the application of Hydropotes inermis Swinhoe gastric contents in the medicine of preparation treatment indigestion.
2. application as claimed in claim 1, wherein said indigestion are that gastric dynamic dysfunction causes.
3. application as claimed in claim 1, wherein said indigestion are that hyposecretion causes by digestive enzyme.
4. application as claimed in claim 1, wherein said indigestion are that hyposecretion causes jointly by gastric dynamic dysfunction and digestive enzyme.
5. the application of Hydropotes inermis Swinhoe gastric contents in the medicine of preparation increase gastric motility.
6. Hydropotes inermis Swinhoe gastric contents promotes that in preparation the peptic digestion enzyme is the application in the excretory medicine.
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| CNA2004100250959A CN1706400A (en) | 2004-06-11 | 2004-06-11 | Application of stomach inclusion of sucking river deer in preparing medicine |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251650A (en) * | 2013-05-20 | 2013-08-21 | 郑亮 | Application of roe milk in preparation of medicine used for preventing and treating gastric cancer and precancerous lesion |
| CN105012627A (en) * | 2015-07-02 | 2015-11-04 | 浙江大学 | Capsule for strengthening stomach and helping digestion and preparation method thereof |
| CN106236775A (en) * | 2016-08-08 | 2016-12-21 | 杭州医学院 | The application in the medicine preparing facilitating digestion or health food of the river deer milk |
-
2004
- 2004-06-11 CN CNA2004100250959A patent/CN1706400A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251650A (en) * | 2013-05-20 | 2013-08-21 | 郑亮 | Application of roe milk in preparation of medicine used for preventing and treating gastric cancer and precancerous lesion |
| CN105012627A (en) * | 2015-07-02 | 2015-11-04 | 浙江大学 | Capsule for strengthening stomach and helping digestion and preparation method thereof |
| CN105012627B (en) * | 2015-07-02 | 2018-10-19 | 浙江大学 | Stomach strengthening and digestion promoting capsule and preparation method thereof |
| CN106236775A (en) * | 2016-08-08 | 2016-12-21 | 杭州医学院 | The application in the medicine preparing facilitating digestion or health food of the river deer milk |
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