CN1698750A - Pharyngitis treating Chinese medicine - Google Patents
Pharyngitis treating Chinese medicine Download PDFInfo
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- CN1698750A CN1698750A CN 200510046307 CN200510046307A CN1698750A CN 1698750 A CN1698750 A CN 1698750A CN 200510046307 CN200510046307 CN 200510046307 CN 200510046307 A CN200510046307 A CN 200510046307A CN 1698750 A CN1698750 A CN 1698750A
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- radix
- herba
- pharyngitis
- chinese medicine
- isatidis
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Abstract
The invention provides a pharyngitis treating Chinese medicine, wherein the charging ratio is, root of ballon flower 5-40g, bamboo leaf 5-40g, spearmint 2-18g, licorice root 2-16g, arctium fruit 3-25g, capsule of weeping forsythia 5-40g, herba schizonepetae 3-17g, kudzuvine root 2-18g, honeysuckle flower 5-40g, dyers woad leaf 5-30g, radix isatidis 5-30g.
Description
(1) technical field
The present invention relates to a kind of Chinese medicine, particularly relate to a kind of Chinese medicine for the treatment of acute/chronic pharyngitis.
(2) background technology
Because the virus of viral disease has strict parasitics, duplicates in parasitic cell, utilizes cellular enzymes system and cell relation close, viral nucleic acid is integrated in cell sometimes and is difficult for eliminating.Therefore, the development of antiviral class medicine is very slow.Anti-virus formulation that existing market is commonly used such as Aminodiamantane, Moroxydine, ribavirin (virazole) are chemicals, Aminodiamantane interior resisting virus activity only limits to suppress influenza A virus, though external also have activity to parainfluenza and rubella virus, valid density is than suppressing the big 50-100 of influenza A virus doubly.Its untoward reaction has delirium, anxiety, insomnia, idol had epilepsy when thought was concentrated difficulty, high plasma concentration, also with congestive heart failure, and diseases such as arrhythmia and netted malicious speckle.Virazole is strong to the RNA viruses effect, and is lower to DNA viruses sensitivity, and untoward reaction is mainly the reversibility anemia, takes hematochrome, RBC number, packed cell volume are descended for a long time.
(3) summary of the invention
The technical problem to be solved in the present invention provides a kind of good effect that has, and pays the Chinese medicine of the little treatment pharyngitis of effect.
The technical scheme that adopts is:
A kind of Chinese medicine for the treatment of pharyngitis, be to be mixed with by Radix Platycodonis, Herba Lophatheri, Semen Sojae Preparatum, Herba Menthae, Radix Glycyrrhizae, Fructus Arctii, Fructus Forsythiae, Herba Schizonepetae, reed root, Flos Lonicerae, Folium Isatidis, Radix Isatidis, its charge ratio is: Radix Platycodonis 5-40g, Herba Lophatheri 5-40g, Herba Menthae 2-18g, Radix Glycyrrhizae 2-16g, Fructus Arctii 3-25g, Fructus Forsythiae 5-40g, Herba Schizonepetae 3-17g, reed root 2-18g, Flos Lonicerae 5-40g, Folium Isatidis 5-30g, Radix Isatidis 5-30g.
A kind of production method for the treatment of the Chinese medicine of pharyngitis:
A, Folium Isatidis is extractd impurity, earth root piece and moth, sheet is broken into small pieces off with the fingers and thumb and is weighed standby.
B, Flos Lonicerae are removed impurity, are cut into segment and weigh standby
C, reed are eradicated decontamination, are cut into segment and weigh standby.
D, other nine flavors medicine are removed impurity and are weighed standby.
2, get above each medicine by the prescription proportioning and fully be blended under the room temperature situation, put into the start of pulverizer funnel and pulverize, enter the pulverizer thorax successively, the fine and closely woven degree of pulverizing reaches and can filter 120 mesh sieves,, the fill capsule is finished product then.
The side separates:
Herba Menthae, the Herba Schizonepetae suffering table that cools completely, Flos Lonicerae, Fructus Forsythiae heat-clearing and toxic substances removing are our principal agent altogether; Semen Sojae Preparatum assists to induce sweat, and Folium Bambusae, reed root are assisted heat clearing away, and double can promoting the production of body fluid is accessory drugs; Radix Isatidis, Folium Isatidis bitter cold are longer than heat-clearing and toxic substances removing; Fructus Arctii, Radix Platycodonis clearing throat are adjuvant drug, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, double can the detoxifcation to making.
The Main Ingredients and Appearance of Herba Menthae is a Mentholum, and low dose can stimulating central nervous system, and can make skin capillary vascular expansion, promotes sweat gland secretion, strengthens the body heat radiation, so the effect of relieving the exterior syndrome by diaphoresis is arranged; The Herba Schizonepetae decoct also can be analgesic; The refrigeration function of Fructus Forsythiae is then similar to the cooling effect of phenazone.The same usefulness of three medicines is played the suffering table that cools completely, the merit of sweating and heat resolving altogether.
Flos Lonicerae has broad-spectrum antibacterial action through the bacteriostatic test proof, it is chlorogenic acid and isochlorogenic acid that staphylococcus, Hemolytic streptococcus, Diplococcus pneumoniae, bacillus pyocyaneus, bordetella pertussis, dysentery bacterium, escherichia coli, Bacillus typhi, Bacillus tuberculosis etc. are all had inhibitory action, its antibiotic active ingredient; This product also can suppress influenza virus.The contained forsythol of Fructus Forsythiae, antimicrobial spectrum is also quite extensive, staphylococcus aureus and dysentery bacterium, Hemolytic streptococcus, Diplococcus pneumoniae, Bacillus typhi are also had than the obvious suppression effect, and this product also can suppress Asia influenza A virus, rhinovirus etc.In addition, the alcohol extract of Fructus Forsythiae can be killed leptospira; Flos Lonicerae still can be resisted inflammatory exudation and hypertrophy, and Radix Isatidis removing heat from blood sore-throat relieving, antivirus action are more extensive, and Fructus Forsythiae also has antiinflammatory action.Gold silver, Fructus Forsythiae, Radix Isatidis three medicines and usefulness, not only antibacterial action strengthens to some extent, and has increased antiviral and antiinflammatory action simultaneously.
Fructus Arctii has inhibitory action to staphylococcus aureus, and can analgesic, diuresis.The Herba Lophatheri decoct has refrigeration function, also can suppress staphylococcus aureus growth, and the reed root then has inhibitory action to beta hemolytic streptococcus, and the energy diuresis, and Radix Platycodonis contains kikyosaponin, and can promote bronchus secretion increase and phlegm-dispelling functions is arranged, and can antiinflammatory.Semen Sojae Preparatum is fatty, protein and enzyme etc., and this product still can be good for the stomach, and Radix Glycyrrhizae has detoxifcation, antiinflammatory, eliminate the phlegm and effect such as antitussive.
Take a broad view of full side, each adjuvant and usefulness have not only been strengthened the merit of analgesic antibiotic, the antiviral of principal agent, and have been made we be longer than sore-throat relieving especially, can eliminate the phlegm again, and rigorous prescription, rational in infrastructure, both effected a permanent cure, also took stopgap measures, thereby reached the purpose for the treatment of both the principal and secondary aspects of a disease.
Function with cure mainly:
Cool completely table, heat-clearing and toxic substances removing, sore-throat relieving of suffering wets one's whistle.Be used for diseases such as acute/chronic pharyngitis, herpangina, influenza, acute tonsillitis.
Adapt to disease, the cause of disease, pathogenesis and method of treatment:
The disease of wind heat, the heresy of wind heat are gone into through mouth and nose, in be contained in due to the lung.Or be affected by the cold in advance, strongly fragrant immediately and heat-transformation, hot smoking lung system, with attack in lung, on burn due to the pharynx, the smoked throat that burns of wind heat is seen red swelling and pain of throat then, again because of lung governing skin and hair, open surreptitiously in nose, so wind heat is attacked in the flesh table, disease is seen fever of the body, distending pain in the head.The heresy of wind heat is invaded lung system, causes disturbance of lung-QI, and sees nasal obstruction stream turbid nasal discharge.For the disease of sore throat, it is controlled when the Gu doctor instruction of following " wind is excessive in interior, controls with hot cool, helps sweet with hardship "; The method that (" element ask the most pure virginity will discuss ") adopts dispelling wind and heat pathogens, heat-clearing and toxic substances removing, sore-throat relieving to wet one's whistle.
[usage is in consumption] is oral, one time four, three times on the one
[specification] every 3g-5g
We have carried out nearly 1 year research and have solved in the Norman Bethune Medical University, the physicochemical property relevant, quality standard, stability test, pharmacodynamics test, acute toxicity test and clinical trial have been finished with quality, the technical problem that needs emphasis to solve is an antivirus test, is born and is finished by its Affiliated Hospital Viral Laboratory the end of the year 04.
This research is leading indicator with the pharyngitis capsule antivirus test, and analgesic, antiinflammatory, antibacterial and pain relieving are auxiliary characteristics.In antivirus test, main prevention and the therapeutical effect of observing pharyngitis capsule to FM/1/47 influenza virus induced mice viral disease, the measurement result of the blood clotting titre by every index, histopathology, virus, RNA, inducement interferon level is come the antivirus action of analysis-by-synthesis pharyngitis capsule.Wherein the mensuration of viral RNA and interferon is that the applied molecular biology technology is finished, and science is reliable as a result.
Acute toxicity test
Method: get 30 of mices, be divided into three groups at random by the body weight size, ten every group, male and female half and half, each organizes mice respectively by observing 7 days behind the dosage gastric infusion single administration of 87g/kg, 69.6g/kg.General situation and the death toll of record mice.
The result:
Table 1 pharyngitis capsule is to the acute toxicity of mouse stomach administration
| Group | Dosage g/kg | Number of animals (only) | Death toll (only) | General situation after the administration |
| First group | ??87.0 | ??10 | ??0 | No abnormal |
| Second group | ??69.6 | ??10 | ??0 | No abnormal |
| The 3rd group | ??56.6 | ??10 | ??0 | No abnormal |
By table 1 result as seen, pharyngitis capsule fails to measure LD for the mouse stomach administration
50
Maximum tolerance determination:
Method:
Get 20 of mices, male and female half and half are all once irritated stomach and are given pharyngitis capsule 87g/kg, observe 7 days continuously after the administration, and observe once every day, general situation and the death toll of record mice.
The result:
Observed after the administration 7 days, none death of mice, general situation, activity and diet are all normal, the big dosis tolerata of the amount of pharyngitis capsule single administration be pharyngitis capsule by 87g/kg, be equivalent to 175 times of people (70kg) daily dose.
Clinical trial
Use pharyngitis capsule treatment chronic pharyngitis 36 examples, adopt Yanyan slice to compare.The pharyngitis capsule group is cured 31 examples as a result, and cure rate is 86.11%, produce effects 3 examples, and obvious effective rate is 8.33%, progressive 2 examples account for 5.55%.The Yanyan slice group is cured 6 examples, cure rate 16.66%, and produce effects 7 examples, obvious effective rate 19.44%, progressive 6 examples account for 16.66%, and invalid 17 examples account for 47.22%.
From clinical efficacy as seen, pharyngitis capsule obviously is better than Yanyan slice.We have also treated 16 routine herpanginas, herpes are disappeared in 3-7 days, and the pharyngitis capsule group also obviously is better than the Yanyan slice group.
(4) specific embodiment
Embodiment one
A kind of Chinese medicine for the treatment of pharyngitis is to be pulverized and be mixed and made into, and made wafer by Radix Platycodonis 6g, Herba Lophatheri 5g, Herba Menthae 4g, Radix Glycyrrhizae 2.5g, Fructus Arctii 4g, Fructus Forsythiae 7g, Herba Schizonepetae 3.5g, reed root 3g, Flos Lonicerae 8g, Folium Isatidis 6.5g, Radix Isatidis 5.5g.
Embodiment two
A kind of Chinese medicine for the treatment of pharyngitis is to make wafer by Radix Platycodonis 10g, Herba Lophatheri 10g, Semen Sojae Preparatum 10g, Herba Menthae 10g, Radix Glycyrrhizae 10g, Fructus Arctii 10g, Fructus Forsythiae 10g, Herba Schizonepetae 10g, reed root 10g, Flos Lonicerae 10g, Folium Isatidis 10g, Radix Isatidis 10g grinding and processing.
Embodiment three
A kind of Chinese medicine for the treatment of pharyngitis is to mix pulverizing by Radix Platycodonis 7g, Herba Lophatheri 5g, Herba Menthae 6g, Radix Glycyrrhizae 4g, Fructus Arctii 4g, Fructus Forsythiae 8g, Herba Schizonepetae 7, reed root 6g, Flos Lonicerae 10g, Folium Isatidis 8g, Radix Isatidis 7.5g, makes wafer.
Embodiment four
A kind of Chinese medicine for the treatment of pharyngitis is to be pulverized through mixing by Radix Platycodonis 14g, Herba Lophatheri 16g, Herba Menthae 11g, Radix Glycyrrhizae 14g, Fructus Arctii 15g, Fructus Forsythiae 17g, Herba Schizonepetae 16g, reed root 12g, Flos Lonicerae 20g, Folium Isatidis 14g, Radix Isatidis 15g, makes wafer.
A kind of production method for the treatment of the Chinese medicine of pharyngitis is: will add in the pulverizer successively after the start in Radix Platycodonis 10g, Herba Lophatheri 10g, Semen Sojae Preparatum 10g, Herba Menthae 10g, Radix Glycyrrhizae 10g, Fructus Arctii 10g, Fructus Forsythiae 10g, Herba Schizonepetae 10g, reed root 10g, Flos Lonicerae 10g, Folium Isatidis 10g, the Radix Isatidis 10g adding pulverizer funnel, grinding and processing can be crossed the fine powder of 120 mesh sieves, fill capsule again, and dress up bottle with filling machine, theoretical amount is 5 bottles, also can be made into tablet or granule.
Claims (5)
1, a kind of Chinese medicine for the treatment of pharyngitis, it is characterized in that being mixed with by Radix Platycodonis, Herba Lophatheri, Semen Sojae Preparatum, Herba Menthae, Radix Glycyrrhizae, Fructus Arctii, Fructus Forsythiae, Herba Schizonepetae, reed root, Flos Lonicerae, Folium Isatidis, Radix Isatidis, its charge ratio is: Radix Platycodonis 5-40g, Herba Lophatheri 5-40g, Herba Menthae 2-18g, Radix Glycyrrhizae 2-16g, Fructus Arctii 3-25g, Fructus Forsythiae 5-40g, Herba Schizonepetae 3-17g, reed root 2-18g, Flos Lonicerae 5-40g, Folium Isatidis 5-30g, Radix Isatidis 5-30g.
2, a kind of Chinese medicine for the treatment of pharyngitis according to claim 1 is characterized in that being pulverized and being hybridly prepared into by Radix Platycodonis 6g, Herba Lophatheri 5g, Herba Menthae 4g, Radix Glycyrrhizae 2.5g, Fructus Arctii 4g, Fructus Forsythiae 7g, Herba Schizonepetae 3.5g, reed root 3g, Flos Lonicerae 8g, Folium Isatidis 6.5g, Radix Isatidis 5.5g.
3, a kind of Chinese medicine for the treatment of pharyngitis according to claim 1 is characterized in that being pulverized and being hybridly prepared into by Radix Platycodonis 10g, Herba Lophatheri 10g, Semen Sojae Preparatum 10g, Herba Menthae 10g, Radix Glycyrrhizae 10g, Fructus Arctii 10g, Fructus Forsythiae 10g, Herba Schizonepetae 10g, reed root 10g, Flos Lonicerae 10g, Folium Isatidis 10g, Radix Isatidis 10g powder.
4, a kind of Chinese medicine for the treatment of pharyngitis according to claim 1 is characterized in that being pulverized and being hybridly prepared into by Radix Platycodonis 7g, Herba Lophatheri 5g, Herba Menthae 6g, Radix Glycyrrhizae 4g, Fructus Arctii 4g, Fructus Forsythiae 8g, Herba Schizonepetae 7, reed root 6g, Flos Lonicerae 10g, Folium Isatidis 8g, Radix Isatidis 7.5g.
5, a kind of Chinese medicine for the treatment of pharyngitis according to claim 1 is characterized in that being hybridly prepared into through pulverizing by Radix Platycodonis 14g, Herba Lophatheri 16g, Herba Menthae 11g, Radix Glycyrrhizae 14g, Fructus Arctii 15g, Fructus Forsythiae 17g, Herba Schizonepetae 16g, reed root 12g, Flos Lonicerae 20g, Folium Isatidis 14g, Radix Isatidis 15g.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100463076A CN100486635C (en) | 2005-04-26 | 2005-04-26 | Pharyngitis treating Chinese medicine |
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|---|---|---|---|
| CNB2005100463076A CN100486635C (en) | 2005-04-26 | 2005-04-26 | Pharyngitis treating Chinese medicine |
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| CN1698750A true CN1698750A (en) | 2005-11-23 |
| CN100486635C CN100486635C (en) | 2009-05-13 |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100409884C (en) * | 2006-04-12 | 2008-08-13 | 曹存德 | Chinese traditional medicine for treating cold |
| CN101181437B (en) * | 2007-11-28 | 2010-06-09 | 李西睦 | Chinese medicine composition orally taken for curing acute tonsillitis |
| CN101474372B (en) * | 2009-02-01 | 2011-04-27 | 贾翠菊 | Method for preparing Chinese medicine for treating children's wind-heat cold |
| CN101874843B (en) * | 2009-12-10 | 2011-12-28 | 陈爱中 | Medicament for treating influenza |
| CN102429298A (en) * | 2011-10-31 | 2012-05-02 | 湖南中医药大学 | Method for preparing functional herbal beverage for protecting throat |
| CN102614403A (en) * | 2012-04-02 | 2012-08-01 | 常州亚环环保科技有限公司 | Chinese patent medicament for treating tonsillitis and preparation method thereof |
| CN103127405A (en) * | 2012-12-20 | 2013-06-05 | 刘登富 | Chinese materia medica preparation for treating child acute upper respiratory infection |
| CN103655693A (en) * | 2012-09-26 | 2014-03-26 | 张献奎 | Traditional Chinese medicine preparation for treating acute tonsillitis |
| CN104474314A (en) * | 2014-11-20 | 2015-04-01 | 西安阿房宫药业股份有限公司 | Composition for treating colds and preparation method of composition |
| CN105663433A (en) * | 2016-02-29 | 2016-06-15 | 戴礼礼 | Pharmaceutical preparation for treating acute pharyngitis and preparation method and use thereof |
| CN105748979A (en) * | 2016-02-26 | 2016-07-13 | 山东中医药大学 | Traditional Chinese medicine compound extract for resisting RSV (respiratory syncytial virus) virus as well as preparation method and application thereof |
| CN107095936A (en) * | 2017-05-09 | 2017-08-29 | 北京同仁堂科技发展股份有限公司 | A kind of Chinese medicine composition for relieving sore-throat of detoxifying and preparation method thereof and purposes |
| CN110538281A (en) * | 2019-09-27 | 2019-12-06 | 首都医科大学附属北京朝阳医院 | traditional Chinese medicine preparation for treating pharyngitis and tonsillitis, preparation method and application |
-
2005
- 2005-04-26 CN CNB2005100463076A patent/CN100486635C/en not_active Expired - Fee Related
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100409884C (en) * | 2006-04-12 | 2008-08-13 | 曹存德 | Chinese traditional medicine for treating cold |
| CN101181437B (en) * | 2007-11-28 | 2010-06-09 | 李西睦 | Chinese medicine composition orally taken for curing acute tonsillitis |
| CN101474372B (en) * | 2009-02-01 | 2011-04-27 | 贾翠菊 | Method for preparing Chinese medicine for treating children's wind-heat cold |
| CN101874843B (en) * | 2009-12-10 | 2011-12-28 | 陈爱中 | Medicament for treating influenza |
| CN102429298A (en) * | 2011-10-31 | 2012-05-02 | 湖南中医药大学 | Method for preparing functional herbal beverage for protecting throat |
| CN102614403A (en) * | 2012-04-02 | 2012-08-01 | 常州亚环环保科技有限公司 | Chinese patent medicament for treating tonsillitis and preparation method thereof |
| CN103655693A (en) * | 2012-09-26 | 2014-03-26 | 张献奎 | Traditional Chinese medicine preparation for treating acute tonsillitis |
| CN103127405B (en) * | 2012-12-20 | 2014-10-22 | 刘登富 | Chinese materia medica preparation for treating child acute upper respiratory infection |
| CN103127405A (en) * | 2012-12-20 | 2013-06-05 | 刘登富 | Chinese materia medica preparation for treating child acute upper respiratory infection |
| CN104474314A (en) * | 2014-11-20 | 2015-04-01 | 西安阿房宫药业股份有限公司 | Composition for treating colds and preparation method of composition |
| CN105748979A (en) * | 2016-02-26 | 2016-07-13 | 山东中医药大学 | Traditional Chinese medicine compound extract for resisting RSV (respiratory syncytial virus) virus as well as preparation method and application thereof |
| CN105748979B (en) * | 2016-02-26 | 2019-08-27 | 山东中医药大学 | A kind of Chinese medicinal compound extract and its preparation method and application of anti-RSV virus |
| CN105663433A (en) * | 2016-02-29 | 2016-06-15 | 戴礼礼 | Pharmaceutical preparation for treating acute pharyngitis and preparation method and use thereof |
| CN107095936A (en) * | 2017-05-09 | 2017-08-29 | 北京同仁堂科技发展股份有限公司 | A kind of Chinese medicine composition for relieving sore-throat of detoxifying and preparation method thereof and purposes |
| CN107095936B (en) * | 2017-05-09 | 2020-08-18 | 北京同仁堂科技发展股份有限公司 | Traditional Chinese medicine composition for detoxifying and relieving sore throat as well as preparation method and application thereof |
| CN110538281A (en) * | 2019-09-27 | 2019-12-06 | 首都医科大学附属北京朝阳医院 | traditional Chinese medicine preparation for treating pharyngitis and tonsillitis, preparation method and application |
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