CN1686347A - Ready prepared Chinese medicine for antiaging and remitting body fatigue - Google Patents
Ready prepared Chinese medicine for antiaging and remitting body fatigue Download PDFInfo
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- CN1686347A CN1686347A CN 200510055644 CN200510055644A CN1686347A CN 1686347 A CN1686347 A CN 1686347A CN 200510055644 CN200510055644 CN 200510055644 CN 200510055644 A CN200510055644 A CN 200510055644A CN 1686347 A CN1686347 A CN 1686347A
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Abstract
A Chinese patent disease in the form of tablet, capsule, particle, etc for delaying senility and relieving fatigue is prepared from 9 Chinese-medicinal materials including ginseng, red sage root, prepared fleece flower root, wolfberry fruit, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of medicine, particularly a kind of defying age, the Chinese patent medicine of alleviating physical fatigue.
Background technology
Aging is an important component part in the profound complicated life process, be all biological natural phenomenas that must take place, but can delay, and to delay is limited.Modern biology is thought: the aging course that too much free radical and too much lipid peroxidation can be accelerated human body in the human body.Therefore, exploitation can ameliorate body in the radical pair body damage or have the medicine of lipoid peroxidization resistant, also promptly have defying age, the medicine that delay fatigue occurs is significant, meets people's demand.
Summary of the invention
The technical problem to be solved in the present invention is aimed at does not have effective medicine with defying age and effect of relieving physical fatigue at present, and Chinese patent medicine of a kind of antiaging and remitting body fatigue and preparation method thereof is provided.
The technical solution used in the present invention is:
A kind of Chinese patent medicine of antiaging and remitting body fatigue is characterized in that it is the medicament of being made by the following weight proportion raw material:
Radix Ginseng 10-25, Herba Epimedii 5-20, Radix Salviae Miltiorrhizae 5-20, Radix Polygoni Multiflori Preparata 5-20, Fructus Lycii 5-20, Fructus Rubi 5-20, Semen Ziziphi Spinosae 5-20, Fructus Crataegi 5-20, dextrin 1-5.
Formula optimization weight (part) ratio range of preparation Chinese patent medicine of the present invention is:
Radix Ginseng 10-15, Herba Epimedii 5-15, Radix Salviae Miltiorrhizae 5-15, Radix Polygoni Multiflori Preparata 5-15, Fructus Lycii 5-15, Fructus Rubi 5-15, Semen Ziziphi Spinosae 5-15, Fructus Crataegi 5-15, dextrin 1-3.
Optimum weight (part) proportioning of preparation Chinese patent medicine of the present invention is:
Radix Ginseng 10, Herba Epimedii 5, Radix Salviae Miltiorrhizae 5, Radix Polygoni Multiflori Preparata 5, Fructus Lycii 5, Fructus Rubi 5, Semen Ziziphi Spinosae 5, Fructus Crataegi 5, dextrin 1.
Above-mentioned each component is made medicine production method of the present invention is:
(a) Radix Ginseng, Herba Epimedii, Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori Preparata, Fructus Lycii, Fructus Rubi, Semen Ziziphi Spinosae, Fructus Crataegi are cleaned, got extracting solution with water extraction;
(b) said extracted liquid is concentrated and mix with dextrin dry back, obtain this medicine after making soft material, drying afterwards.
The preferred mode of operation of the preparation method of medicine of the present invention is as follows further: extracting operation in the step (a) is that water decocts three times, be respectively that the pure water that adds for the first time 10 times of volumes extracted 2 hours, for the second time be that the pure water that adds 8 times of volumes extracted 1.5 hours, be that the pure water that adds 6 times of volumes extracted 1 hour for the third time, and collect extracting solution and merge three times extracting solution in each back of extracting; Concentration operation adopts the rotary evaporation in vacuo mode in the step (b); The spray drying mode is adopted in drying process; With 95% straight alcohol system soft material.
The pharmacological action of forming each component of the present invention is:
Radix Ginseng, its pharmacological action of Herba Epimedii are more extensive, have strongly invigorating primordial QI, regulating QI nourish blood, the calm the nerves effect of Fructus Alpiniae Oxyphyllae, the cough-relieving of promoting the production of body fluid, nourishing and fit keeping function.Wherein Herba Epimedii contains a large amount of flavones ingredients, has stronger lipoid peroxidization resistant, has the effect of slow down aging.The effect of the anti peroxidation of lipid of Radix Ginseng is not as good as Herba Epimedii, but can obviously strengthen the effect of Herba Epimedii.
Radix Salviae Miltiorrhizae has the effect of removing the endogenous free radical that fatigability campaign produced, and can block the chain reaction of lipid peroxidation, strengthens the activity of the interior antioxidase of body; thereby alleviate the damage of oxygen-derived free radicals to body; the protection biofilm structure improves rats'swimming endurance, the appearance of delay fatigue.
Radix Polygoni Multiflori Preparata is the process of preparing Chinese medicine processed goods of Radix Polygoni Multiflori, and Radix Polygoni Multiflori Preparata has the effect of the kidney invigorating and essence nourishing.Modern study shows that Radix Polygoni Multiflori can significantly resist the active reduction of SOD in old rats, the mouse tissue (superoxide dismutase), strengthens its SOD content, improves GSH-PX (glutathion peroxidase) content, thereby can remove interior free yl.
Fructus lycii extracted solution can obviously suppress the generation of mouse liver even slurry LPO (serum lipid peroxide) in vitro; Experiment confirms that also fructus lycii extracted solution can obviously suppress the generation of its liver LPO in the mice body, and makes that the vigor of GSH-PX vigor and erythrocyte sod increases in the blood; Human experimentation confirms that fructus lycii extracted solution can obviously suppress the generation of Serum LPO, and the vigor of the GSH-PX in the blood is increased.Above-mentioned experimental result shows that fructus lycii extracted solution can alleviate intravital lipid peroxidation, thereby has antioxidation, antidotal effect.
Semen Ziziphi Spinosae has the function of tranquilizing by nourishing the heart, and it mainly contains materials such as fatty oil, flavone and Saponin.Modern pharmacology studies show that Semen Ziziphi Spinosae has protective effect to the reduction of the intravital SOD of heating mice of endotoxin induced, and this result of study prompting Semen Ziziphi Spinosae has the antioxidative activity.
The Flavonoid substances that Fructus Rubi and Fructus Crataegi contain has significant antioxidant role.
In sum, Radix Ginseng, Herba Epimedii can alleviating physical fatigue and both compatibilities have cooperative effect, make the antioxidation of Herba Epimedii strengthen; Radix Polygoni Multiflori Preparata, Fructus Lycii, Fructus Rubi, Radix Salviae Miltiorrhizae, Semen Ziziphi Spinosae, Fructus Crataegi have the antioxidative effect, so the compatibility of mentioned component has the health care of antioxidation, alleviating physical fatigue.
Implementation result
Implementation result 1
The B200408304 inspection report that is numbered that West China Institute of Analysis of HSPH of Sichuan University provides shows, adopt male ICR mouse, laboratory animal is divided into blank group and three at random irritates stomach 270mg/kg.bw, 540mg/kg.bw, 800mg/kg.bw 30 days experimental group of medicine involved in the present invention respectively, the result shows that the time of 800mg/kg.bw dosage group mice swimming with a load attached to the body significantly is longer than the blank group; Mice swimming back 0min blood lactic acid content and three time point blood lactic acid area under curve of three dosage groups significantly are lower than the blank group; 540mg/kg.bw the Mouse Liver glycogen content of dosage group is significantly higher than the blank group.According to evaluation criterion, medicine involved in the present invention has the effect of alleviating physical fatigue.
Implementation result 2
The B200408305 inspection report that is numbered that West China Institute of Analysis of HSPH of Sichuan University provides shows, adopt aged Mus to experimentize, laboratory animal is divided into the experimental group that blank group and three irritate stomach 133.3mg/kg.bw, 266.7mg/kg.bw, 533.3mg/kg.bw medicine involved in the present invention respectively at random, other establishes one and lacks Mus matched group in age, the result shows that MDA (lipid peroxide) significantly is lower than aged Mus matched group in the hepatic tissue of 533.3mg/kg.bw dosage group mice; The activity of SOD is significantly higher than aged Mus matched group in the erythrocyte.According to evaluation criterion, the laboratory animal result of the anti-oxidation function of medicine involved in the present invention is positive.
Implementation result 3
The B200408306 inspection report that is numbered that West China Institute of Analysis of HSPH of Sichuan University provides shows, acceptable age is the 45-65 good crowd of physical condition in year, be divided into two groups of blank group and experimental grouies at random, wherein experimental group everyone every day of oral 1.6g medicine involved in the present invention is three months, the result shows, experimental group experiment back significantly raises with the preceding relatively SOD of experiment is active, with matched group significantly rising.According to evaluation criterion, medicine involved in the present invention has the antioxidative effect.
In sum, medicine involved in the present invention has the effect of significant antioxidation, defying age and alleviating physical fatigue.
The specific embodiment
Further specify the present invention below by embodiment.
By specified component in the following table 1, get the component of specified wt ratio, prepare the Chinese patent medicine of antiaging and remitting body fatigue involved in the present invention according to production method as described below.
Above-mentioned each component is made medicine production method of the present invention is:
(a) Radix Ginseng, Herba Epimedii, Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori Preparata, Fructus Lycii, Fructus Rubi, Semen Ziziphi Spinosae, Fructus Crataegi are cleaned in Radix Ginseng, Herba Epimedii, Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori Preparata, Fructus Lycii, Fructus Rubi, Semen Ziziphi Spinosae, mountain, get extracting solution with water extraction;
(b) said extracted liquid is concentrated and mix with dextrin dry back, obtain this medicine after making soft material, drying afterwards.
The preferably water that extracts operation in the above-mentioned preparation method decocts three times, be respectively that the pure water that adds for the first time 10 times of volumes extracted 2 hours, for the second time be that the pure water that adds 8 times of volumes extracted 1.5 hours, be that the pure water that adds 6 times of volumes extracted 1 hour for the third time, and collect extracting solution and merge three times extracting solution in each back of extracting; The preferred mode of rotary evaporation in vacuo that adopts concentrates in the step (b), preferably adopts the spray drying mode to carry out drying; Preferably with 95% ethanol system soft material.
Dried medicine can obtain multiple dosage form through handling again, and wherein the preferred process mode of granule is granulated for further the raw material behind the system soft material in the step (b) being crossed 16 mesh sieves, crosses 14 mesh sieve granulate 60 ℃ of down dry backs and obtains granule.The granule that makes can be filled with Autocapsulefillingmachine in addition and obtain capsule, capsular preferred filling specification is the 0.4g/ grain.
The present invention relates to the instructions of taking of medicine, be preferably oral for each person every day secondary, each 800mg granule or capsule.
Table 1
| Set of dispense is than (weight) | Radix Ginseng | Herba Epimedii | Radix Salviae Miltiorrhizae | Radix Polygoni Multiflori Preparata | Fructus Lycii | Fructus Rubi | Semen Ziziphi Spinosae | Fructus Crataegi | Dextrin |
| Embodiment 1 | ??10 | ??20 | ??10 | ??20 | ??10 | ??5 | ??20 | ??10 | ??1 |
| Embodiment 2 | ??20 | ??15 | ??20 | ??5 | ??5 | ??20 | ??10 | ??20 | ??3 |
| Embodiment 3 | ??25 | ??5 | ??5 | ??15 | ??20 | ??15 | ??5 | ??5 | ??5 |
| Embodiment 4 | ??10 | ??15 | ??5 | ??5 | ??15 | ??10 | ??10 | ??15 | ??3 |
| Embodiment 5 | ??15 | ??10 | ??10 | ??15 | ??5 | ??5 | ??15 | ??10 | ??2 |
| Embodiment 6 | ??20 | ??5 | ??15 | ??10 | ??10 | ??15 | ??5 | ??5 | ??1 |
| Embodiment 7 | ??10 | ??5 | ??5 | ??5 | ??5 | ??5 | ??5 | ??5 | ??1 |
Claims (8)
1, a kind of Chinese patent medicine of antiaging and remitting body fatigue is characterized in that it is the medicament of being made by the following weight proportion raw material:
Radix Ginseng 10-25, Herba Epimedii 5-20, Radix Salviae Miltiorrhizae 5-20, Radix Polygoni Multiflori Preparata 5-20, Fructus Lycii 5-20, Fructus Rubi 5-20, Semen Ziziphi Spinosae 5-20, Fructus Crataegi 5-20, dextrin 1-5.
2, the Chinese patent medicine of antiaging and remitting body fatigue according to claim 1, wherein the weight proportion of each raw material is:
Radix Ginseng 10-20, Herba Epimedii 5-15, Radix Salviae Miltiorrhizae 5-15, Radix Polygoni Multiflori Preparata 5-15, Fructus Lycii 5-15, Fructus Rubi 5-15, Semen Ziziphi Spinosae 5-15, Fructus Crataegi 5-15, dextrin 1-3.
3, the Chinese patent medicine of antiaging and remitting body fatigue according to claim 1, wherein the weight proportion of each raw material is:
Radix Ginseng 10, Herba Epimedii 5, Radix Salviae Miltiorrhizae 5, Radix Polygoni Multiflori Preparata 5, Fructus Lycii 5, Fructus Rubi 5, Semen Ziziphi Spinosae 5, Fructus Crataegi 5, dextrin 1.
4,, it is characterized in that described medicament is tablet, capsule, granule, unguentum, pill or drop according to the Chinese patent medicine of the described antiaging and remitting body fatigue of the arbitrary claim of claim 1-3.
5, the Chinese patent medicine of antiaging and remitting body fatigue according to claim 4 is characterized in that described medicament is capsule or granule.
6, a kind of method for preparing the Chinese patent medicine of the described antiaging and remitting body fatigue of the arbitrary claim of claim 1-3, this method may further comprise the steps:
(a) Radix Ginseng, Herba Epimedii, Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori Preparata, Fructus Lycii, Fructus Rubi, Semen Ziziphi Spinosae, Fructus Crataegi are cleaned, got extracting solution with water extraction;
(b) said extracted liquid is concentrated and mix with dextrin dry back, obtain this medicine after making soft material, drying afterwards.
7, the preparation method of the Chinese patent medicine of antiaging and remitting body fatigue according to claim 6, it is characterized in that extracting in the step (a) operation is that water decocts three times, be respectively that the pure water that adds for the first time 10 times of volumes extracted 2 hours, for the second time be that the pure water that adds 8 times of volumes extracted 1.5 hours, be that the pure water that adds 6 times of volumes extracted 1 hour for the third time, and collect extracting solution and merge three times extracting solution in each back of extracting; The spray drying mode is adopted in drying process in the step (b); With 95% ethanol system soft material.
8, the preparation method of the Chinese patent medicine of antiaging and remitting body fatigue according to claim 7 is characterized in that comprising further that the raw material behind the system soft material in the step (b) is crossed 16 mesh sieves granulates, and crosses 14 mesh sieve granulate 60 ℃ of down dry backs and obtains granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100556441A CN1298355C (en) | 2005-03-21 | 2005-03-21 | Ready prepared Chinese medicine for antiaging and remitting body fatigue |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100556441A CN1298355C (en) | 2005-03-21 | 2005-03-21 | Ready prepared Chinese medicine for antiaging and remitting body fatigue |
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| Publication Number | Publication Date |
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| CN1686347A true CN1686347A (en) | 2005-10-26 |
| CN1298355C CN1298355C (en) | 2007-02-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2005100556441A Expired - Fee Related CN1298355C (en) | 2005-03-21 | 2005-03-21 | Ready prepared Chinese medicine for antiaging and remitting body fatigue |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512498A (en) * | 2012-01-01 | 2012-06-27 | 山东大学威海分校 | Preparation method for compound salvia miltiorrhiza preparation and antioxidant activity thereof |
| CN102949521A (en) * | 2012-11-23 | 2013-03-06 | 西安泰科迈医药科技有限公司 | Pure traditional Chinese medicinal health care product used for relieving physical fatigue and preparation method thereof |
| CN104224885A (en) * | 2014-09-11 | 2014-12-24 | 上海焦点生物技术有限公司 | Traditional Chinese medicine composition for relieving physical fatigue |
| CN108606325A (en) * | 2018-05-09 | 2018-10-02 | 哈尔滨工业大学 | A kind of earthquake relief work personnel it is special it is antifatigue stress instant preparation method |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1098639A (en) * | 1993-08-07 | 1995-02-15 | 长沙制药厂 | Anti-senile preparation |
| CN1115156C (en) * | 2000-04-17 | 2003-07-23 | 李熙德 | Antisenility Chinese medicine |
| CN1248721C (en) * | 2003-05-19 | 2006-04-05 | 广东明珠药业有限公司 | Chinese medicine composition for treating consumptive disease and its quality control method |
-
2005
- 2005-03-21 CN CNB2005100556441A patent/CN1298355C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512498A (en) * | 2012-01-01 | 2012-06-27 | 山东大学威海分校 | Preparation method for compound salvia miltiorrhiza preparation and antioxidant activity thereof |
| CN102512498B (en) * | 2012-01-01 | 2013-10-23 | 山东大学威海分校 | Preparation method for compound salvia miltiorrhiza preparation and antioxidant activity thereof |
| CN102949521A (en) * | 2012-11-23 | 2013-03-06 | 西安泰科迈医药科技有限公司 | Pure traditional Chinese medicinal health care product used for relieving physical fatigue and preparation method thereof |
| CN104224885A (en) * | 2014-09-11 | 2014-12-24 | 上海焦点生物技术有限公司 | Traditional Chinese medicine composition for relieving physical fatigue |
| CN108606325A (en) * | 2018-05-09 | 2018-10-02 | 哈尔滨工业大学 | A kind of earthquake relief work personnel it is special it is antifatigue stress instant preparation method |
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| Publication number | Publication date |
|---|---|
| CN1298355C (en) | 2007-02-07 |
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Owner name: WUHAN JIANKANG XINTIANDI PHARMACEUTICAL TECHNOLOGY Free format text: FORMER OWNER: ZHANG KUISHENG Effective date: 20120121 |
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Effective date of registration: 20120121 Address after: Wuhan City, Hubei province 430023 River Road, Jianghan Economic Development Zone No. 8 Building 7 floor LoveGod Entrepreneurship Patentee after: Wuhan Jiankangxintiandi Medical Technology Co., Ltd. Address before: 325200, Zhejiang, Ruian Province on the streets looking at the office of the road community head village Patentee before: Zhang Kuisheng |
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