CN1686215A - Bone healthy pill used for treating protrasion of lumbar intervertebral disci - Google Patents
Bone healthy pill used for treating protrasion of lumbar intervertebral disci Download PDFInfo
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Abstract
A Chinese medicine 'Gukang Jiansheng pill' for treating lumbar intervertebral disk protrusion is prepared from 12 Chinese-medicinal materials including white peony root, Chinese angelica root, pilose asiabell root, Dragon's blood, etc.
Description
Technical field
The present invention relates to Chinese medicine, particularly relate to a kind of bone healthy pill that is used for the treatment of prolapse of lumbar intervertebral disc.
Background technology
The human spine clips intervertebral by vertebra and forms.The pressure that intervertebral disc is subjected in the time of can cushioning spinal motion, the protection spinal cord.Along with the growth at people's age, the vertebral pulp water content reduces, and fibrous elasticity on every side reduces.Long-term chronic strain or sprain suddenly can make annulus fibrosus disci intervertebralis break, and intermediary vertebral pulp is outwards mobile, even is extruded outside the fibrous ring, medically is called prolapse of lumbar intervertebral disc, and the lighter is an annuler bulge disease.
Prolapse of lumbar intervertebral disc is clinical common frdquently encountered disease, serves as main performance with lumbago and skelalgia, waist limitation of activity, sometimes with numbness, and the severe patient even the life of can not taking care of oneself.
Prolapse of lumbar intervertebral disc belongs to motherland's medical science " lumbago ", " lumbago and skelalgia " category.The traditional Chinese medical science thinks, disease in trunk, then the function of motion is not normal, and is movable unfavorable.In " element ask thorn lumbago a piece of writing ", just mention " belt vessel makes us lumbago, cannot pitching, face upward then and probably fall forward, weight lifting hinder waist ".It is impaired that its cause of disease mostly is wound, in have lose empty or be affected by the cold, damp etc., be divided into qi depression to blood stasis, wind chill blockage so distinguish its clinical disease, types such as caused by liver and kidney deficiency.
Prolapse of lumbar intervertebral disc is mainly in 30～50 person between twenty and fifty, and the old people more than 55 years old is more rare, accounts for 14.5% of primary disease sum.Prolapse of lumbar intervertebral disc, the traditional Chinese medical science is divided into Blood stasis, cold-damp disease, damp-heat syndrome, caused by liver and kidney deficiency disease etc. by disease, cause of disease difference, medication is also had any different.At present, most of medicine is to belong to comprehensive prescription, does not have according to traditional Chinese medical science disease and classifies." Taiping Royal Prescriptions. roll up 44. it is all to control waist hip pain " and say: " so husband's waist hip pain person wins by the QI and blood skin natural fibre line of meat is empty, and is subjected to air-cooled also.Kidney master waist foot, kidney master weakness, as the cold with fair wind visitor of ailment said due to cold or exposure institute between the waist hip, so make the pain ear." therefore according to the prolapse of lumbar intervertebral disc of various diseases, carry out the Therapeutic Method that different pharmaceutical stresses, can yet be regarded as and treat the good recipe of prolapse of lumbar intervertebral disc.
At present, the Therapeutic Method of clinically prolapse of lumbar intervertebral disc being carried out is varied.Doctor trained in Western medicine adopts the operative treatment primary disease, and its principle is in the outstanding intervertebral disc of excision, suitably excises downright bad ligament, part joint or the vertebral plate that thickens, to remove spinal canal stenosis or root compression.Tcm syndrome differentiation and treatment comprises oral administration and externally Chinese patent medicine, manual massage, lumbar traction etc., can play tangible blood circulation promoting and blood stasis dispelling, the anti-inflammatory analgetic effect.Modern medicine also confirms, the oral medicinal herb reaction that can reduce inflammation is shortened inflammatory phase and alleviate connective tissue forming, and promotes degenerated nerve fibers to recover, and reducing gtelatinous fibre increases, and alleviates cicatrix to the extruding of peripheral nerve tissue etc.
Summary of the invention
Purpose of the present invention just is being based on above-mentioned existing in prior technology problem, a kind of bone healthy pill that is used for the treatment of prolapse of lumbar intervertebral disc of developing according to Traditional Chinese medical theory, this medicine has adjusting and reinforcing liver and kidney, nourishing YIN and supplementing blood, the function of tendons relaxing and meridians dredging is specially adapted to the clinical treatment of intervertebral disk hernia (renal deficiency type).
The present invention realizes by following scheme: the bone healthy pill that originally is used for the treatment of prolapse of lumbar intervertebral disc is to be made by following materials of weight proportions:
90～95 parts of 132～138 portions of Radix Paeoniae Albas of 132～137 parts of Cortexs Eucommiae of Radix Rehmanniae Preparata
90～95 parts of 89～94 parts of Radix Codonopsis of 89～94 parts of Radix Angelicae Sinensis of Herba Pyrolae
67～72 parts in 67～71 parts of Rhizoma Gastrodiaes of 67～71 parts of Squama Maniss of Sanguis Draxonis
67～71 parts of 67～72 parts of Radix Achyranthis Bidentataes of 67～71 portions of Caulis Spatholobis of the Rhizoma Atractylodis Macrocephalae.
The compound method and the technological process of this medicine are as follows:
Join part at first by weight than taking by weighing above-mentioned 12 flavor medicines, divide two groups of processing levigations:
First group: Radix Angelicae Sinensis, pulverize with Universalpulverizer earlier, sieve, flour extraction is 96～98%.The gained fine powder, the processing sterilization.This medicine contains volatile component, and it is long to be difficult for heat time heating time, sterilize up to standard after, sealed storage, with anti-pollution, stand-by.
Second group, Radix Rehmanniae Preparata, the Cortex Eucommiae, the Radix Paeoniae Alba, Herba Pyrolae, Radix Codonopsis, Sanguis Draxonis, Squama Manis, Rhizoma Gastrodiae, the Rhizoma Atractylodis Macrocephalae, Caulis Spatholobi, Radix Achyranthis Bidentatae, mix homogeneously drops into Universalpulverizer and pulverizes, and sieves, and flour extraction is 96～98%.The gained fine powder, heat sterilization.Heating-up temperature is 100 degree.According in batches what, sterilize 25～40 minutes, total number of bacteria by 10000-100000/g reduce to 500/below the g, mycete by 1000-1500 individual/g is reduced to 100/g, airtight preservation.
With above two groups of fine powder mix homogeneously, add purified water, drop into pill in the pellet processing machine.Wet ball is after the following drying of 60～90 degree, and irregular parts such as the dispersion in the rejecting pill, distortion are upward spared Pulvis Talci, and with the above active carbon coating of 120 orders, consumption is about 0.3%, after the polishing.
The pharmacological property of medicine of the present invention is analyzed as follows:
Radix Rehmanniae Preparata, sweet, tepor is enriched blood, YIN nourishing." book on Chinese herbal medicine is just " said: " deficiency of YIN and the refreshing person that looses, the keeping of non-Radix Rehmanniae Preparata, be not enough to poly-it; The deficiency of YIN and the fiery person of liter, non-Radix Rehmanniae Preparata is heavy, is not enough to fall it; The deficiency of YIN and restless person, non-Radix Rehmanniae Preparata quiet is not enough to press down it; The deficiency of YIN and firm anxious person, non-Radix Rehmanniae Preparata sweet, be not enough to slow it." Radix Paeoniae Alba, bitter in the mouth, acid, be slightly cold, go into Liver Channel.Has easing the affected liver to relieve pain, the yin fluid astringing that nourishes blood, suppressing liver-YANG.Two medicines share has nourishing YIN and supplementing blood, and the function of gentle kidney is monarch drug.
The Cortex Eucommiae, sweet, little suffering, temperature are gone into liver, kidney channel.Invigorating the liver and kidney is arranged, the effect of strengthening bone and muscle." herbal classic " speech: " strong invigorating the liver and kidney, through bottom muscles and bones QI and blood ...." it is unable to cure mainly soreness of the waist and knees for Herba Pyrolae, kidney invigorating and YANG supporting.Radix Angelicae Sinensis, sweet, hot, bitter, warm, go into liver, the heart, spleen channel.Have enrich blood, invigorate blood circulation, the effect of pain relieving." " book on Chinese herbal medicine through hundred kinds of records " said: " Radix Angelicae Sinensis is hot fragrant and moisten, and perfume (or spice) is then gone into spleen, and profit is then enriched blood, thus the branch of burnt ying-qi in penetrating, and be the panacea of nourishing YIN ".Radix Codonopsis, sweet in the mouth, flat is gone into spleen, lung meridian." Bencao Congxin " said: " main invigorating the spleen and replenishing QI, and taste, relieving thirst and restlessness a little less than the middle feeble QI, are mended in order to transfer, and be very smooth and proper." above four flavors are ministerial drug.
Sanguis Draxonis, sweet, one-tenth, flat is gone into heart born of the same parents, Liver Channel.The effect that the clots absorbing pain relieving is arranged." Haiyao Bencao, Oversea Materia Medica " says " traumatic fracture to beat and decrease all pain ... internal injury muscles and bones ".Squama Manis is gone into liver, stomach warp, can the meridian dredging.Rhizoma Gastrodiae, sweet, hot, warm, go into Liver Channel.Be used for numb limbs and tense tendons, hands and feet caused by paralysis.Caulis Spatholobi, blood circulation promoting and enriching.More than four flavors for adjuvant drug.
The Rhizoma Atractylodis Macrocephalae helps adjuvant drug, invigorating the spleen and replenishing QI, dampness diuretic.Radix Achyranthis Bidentatae is gone into liver, kidney channel." Bencao Jingshu " said: " walk and can mend, property is kind descending." the lower limb guiding drug is messenger drug.
Total top of seeing, based on nourishing YIN and supplementing blood, adjusting and reinforcing liver and kidney, lumbago blood deficiency deficiency of the kidney is mark, invigorate blood circulation to enrich blood again, nourishing the liver and kidney consolidates for being aided with, reinforcement and elimination in combination, treating both the principal and the secondary aspects of a disease at the same time, pathogenesis hits.Side's medicine is formed the slow product of gentle property that mostly are, and no Da Xin, big heat, high strong agent in Great Cold are beneficial to patient and take for a long time.
Clinical observation and test data
(1) clinical observation: from the court's outpatient service, inpatient, select 100 routine model cases, the men and women half and half, and age bracket is respectively 18～30 years old 20 example, 30～40 years old 30 example, 40～50 years old 40 example, 10 examples more than 50 years old.
The channels sootheing and network vessel quickening pill that separate case is declared patent, the course of treatment and curative effect are taken in the present invention's cooperation: one month is a course of treatment, takes three courses of treatment continuously, takes medicine every day 3 times, and each 6 grams simultaneously, are aided with maneuver massage, traction and plaster outer plaster, hardboard bed rest for sleeping in etc.Course of disease 1-3 person effective percentage is 96%, and 3-5 person's effective percentage is 89%, and 5-7 person's effective percentage is 75%.This shows that the treatment prolapse of lumbar intervertebral disc is the rule of treatment with blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian, it is evident in efficacy to take bone healthy pill of the present invention; And the course of disease time, short more curative effect was remarkable more, so this disease is early to find that early treatment is for well.
(2) drug effect, toxicological test:
Great new medicine science and technology institute result of the test is as follows through Henan:
Acute toxicity test: with this medicine be equivalent to clinical application 120 extraordinarily pure water be mixed with suspension, give mouse stomach, a continuous week is seen and looks into, and acute toxic reaction and death do not occur, the figure is normal, healthy survival.
Long term toxicity test: the 30-50 that this medicine is equivalent to clinical application doubly is mixed with suspension, give rat oral gavage, 3 months experimental periods (clinical 1 month), observe, body weight, dietary amount, outward appearance sign, behavioral activity, the mental status, comprise that feces and character are no abnormal, the slowness toxic reaction do not occur.
The test of pesticide effectiveness: be mice, rat paw, ears, blood capillary, the administration respectively of two axil otch, cause inflammation, pain and swelling etc., the 10-20 of this medicine clinical application doubly is mixed with suspension with pure water is rat oral gavage, be mouse stomach with being equivalent to 12.5-25 times of suspension, sight in continuous 7 days is looked into, and medicine of the present invention has tangible detumescence, antiinflammatory, analgesic activity.
The present invention has following advantage compared to existing technology: non-operative treatment, medication for oral administration, expense is low, and the patient is no pain in therapeutic process, this medicine adjusting and reinforcing liver and kidney, nourishing YIN and supplementing blood, relaxing muscles and tendons and activating QI and blood in the collateral, be particularly suitable for treatment to the prolapse of lumbar intervertebral disc kidney deficiency, and treating both the principal and secondary aspects of a disease, Special medicine for special disease, with strong points, therapeutic effect is good.
The specific embodiment
The present invention is described further below in conjunction with embodiment, but does not limit the present invention:
Embodiment 1
(1) join part by weight and state 12 herbal medicines than taking off:
Radix Rehmanniae Preparata 132g Cortex Eucommiae 132g Radix Paeoniae Alba 92g Herba Pyrolae 90g Radix Angelicae Sinensis 90g
Radix Codonopsis 90g Sanguis Draxonis 68g Squama Manis 68g Rhizoma Gastrodiae 69g Rhizoma Atractylodis Macrocephalae 68g
Caulis Spatholobi 70g Radix Achyranthis Bidentatae 68g.
(2) Radix Angelicae Sinensis is pulverized with Universalpulverizer earlier, sieved, flour extraction is 96～98%.The gained fine powder, the processing sterilization.This medicine contains volatile component, and it is long to be difficult for heat time heating time, sterilize up to standard after, sealed storage, with anti-pollution, stand-by.
(3) Radix Rehmanniae Preparata, the Cortex Eucommiae, the Radix Paeoniae Alba, Herba Pyrolae, Radix Codonopsis, Sanguis Draxonis, Squama Manis, Rhizoma Gastrodiae, the Rhizoma Atractylodis Macrocephalae, Caulis Spatholobi, Radix Achyranthis Bidentatae, mix homogeneously drops into Universalpulverizer and pulverizes, and sieves, and flour extraction is 96～98%.The gained fine powder, heat sterilization.Heating-up temperature is 100 degree.According in batches what, sterilize 25～40 minutes, total number of bacteria by 10000-100000/g reduce to 500/below the g, mycete by 1000-1500 individual/g is reduced to 100/g, airtight preservation.
(4) with above two groups of fine powder mix homogeneously, add purified water, drop into pill in the pellet processing machine.Wet ball is after the following drying of 60～90 degree, and irregular parts such as the dispersion in the rejecting pill, distortion are upward spared Pulvis Talci, and with the above active carbon coating of 120 orders, consumption is about 0.3%, is medicine of the present invention after the polishing.
Embodiment 2
Join part by weight and state 12 herbal medicines than taking off:
Radix Rehmanniae Preparata 136g Cortex Eucommiae 136g Radix Paeoniae Alba 94g Herba Pyrolae 93g Radix Angelicae Sinensis 93g
Radix Codonopsis 94g Sanguis Draxonis 70g Squama Manis 70g Rhizoma Gastrodiae 72g Rhizoma Atractylodis Macrocephalae 70g
Caulis Spatholobi 68g Radix Achyranthis Bidentatae 69g.
The preparation method of present embodiment and embodiment 1 are identical.
Claims (1)
1, a kind of bone healthy pill that is used for the treatment of prolapse of lumbar intervertebral disc is characterized in that: it is to be made by following materials of weight proportions:
90～95 parts of 132～138 portions of Radix Paeoniae Albas of 132～137 parts of Cortexs Eucommiae of Radix Rehmanniae Preparata
90～95 parts of 89～94 parts of Radix Codonopsis of 89～94 parts of Radix Angelicae Sinensis of Herba Pyrolae
67～72 parts in 67～71 parts of Rhizoma Gastrodiaes of 67～71 parts of Squama Maniss of Sanguis Draxonis
67～71 parts of 67～72 parts of Radix Achyranthis Bidentataes of 67～71 portions of Caulis Spatholobis of the Rhizoma Atractylodis Macrocephalae.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100174803A CN1270744C (en) | 2005-04-01 | 2005-04-01 | Bone healthy pill used for treating protrasion of lumbar intervertebral disci |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100174803A CN1270744C (en) | 2005-04-01 | 2005-04-01 | Bone healthy pill used for treating protrasion of lumbar intervertebral disci |
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| Publication Number | Publication Date |
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| CN1686215A true CN1686215A (en) | 2005-10-26 |
| CN1270744C CN1270744C (en) | 2006-08-23 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100998681B (en) * | 2006-01-13 | 2010-12-08 | 许定高 | Traditional Chinese medicine composition for treating prolapse of lumbar intervertebral disc shift |
| CN101337003B (en) * | 2007-07-05 | 2011-01-12 | 陈全保 | Traditional Chinese medicine preparation for treating lumbar intervertebral disc protrusion and sciatica |
-
2005
- 2005-04-01 CN CNB2005100174803A patent/CN1270744C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100998681B (en) * | 2006-01-13 | 2010-12-08 | 许定高 | Traditional Chinese medicine composition for treating prolapse of lumbar intervertebral disc shift |
| CN101337003B (en) * | 2007-07-05 | 2011-01-12 | 陈全保 | Traditional Chinese medicine preparation for treating lumbar intervertebral disc protrusion and sciatica |
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| Publication number | Publication date |
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| CN1270744C (en) | 2006-08-23 |
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