CN1686065A

CN1686065A - Safety enhanced condom

Info

Publication number: CN1686065A
Application number: CN 200510075087
Authority: CN
Inventors: 易乃君
Original assignee: Individual
Current assignee: Individual
Priority date: 2005-06-09
Filing date: 2005-06-09
Publication date: 2005-10-26

Abstract

A high-safety condom able to suppress and kill parasites, bacteria, fungus and viruses features that its lubricant contains the extracts of grapefruit seed, aloe and honeysuckle flower, VE and ether nonylphenylalkoxide.

Description

A kind of condom that improves safety

Technical field the present invention relates to a kind of condom, especially the condom that contains grapefruit seed extract (being called for short GSE gold micel), Aloe extract, Flos Lonicerae extract, vitamin E, nonoxynolum composition in the lubricant, the contraceptive efficacy that not only has conventional condom, and can press down parasiticide, pathogenic bacteria, fungus, virus (comprising common sex desease virus, HIV virus), reach antibiotic, antiinflammatory, kill smart, as to nourish nursing multi-efficiency, improved the safety effect of condom.

Background technology is along with the rapid spread of sexually transmitted disease (STD) such as acquired immune deficiency syndrome (AIDS), sexually transmitted disease (STD), and condom has been not only the instrument of family planning, simultaneously also is to stop sexually transmitted disease (STD) to spread one of effective method.Because conventional condom in use, can only be blocked the barrier of body (promptly by) by physics, in case situations such as condom breaks, leakage, slippage occur, the risk that very likely increases unexpected gestation and catch.Therefore, even be badly in need of a kind ofly breaking, unexpected phenomenons such as leakage, slippage, still can guarantee the condom of safe-sex practices.

The condom that contains the nonoxynolum spermicide at present on the domestic market in the existing condom lubricant occurs.But the condom that there is no composite partss such as containing grapefruit seed extract (GSE gold micel), Aloe extract, Flos Lonicerae extract, vitamin E, nonoxynolum occurs.Owing to materials such as grapefruit seed extract (GSE gold micel), Aloe extract, Flos Lonicerae extract, vitamin E, nonoxynolum are not organically combined, and directly be added in the lubricant of condom, be not enough to guarantee the safe handling of condom in sexual life.

In addition, grapefruit seed extract (GSE gold micel) is the natural plant broad spectrum antimicrobicide of generally acknowledging already in the U.S., parasite, antibacterial, fungus, virus (comprising sex desease virus, HIV virus) there are significant inhibitory or killing effect, render a service high 10～100 times than conventional antibacterial; Safe in utilization, without any side effects, and tool biological degradability, being widely used in industries such as agricultural, the processing of poultry Fish, food processing, Cosmetic Manufacture, water treatment, medical treatment, is ideal environmental protective broad spectrum antibacterial, disinfectant, insecticide, antiseptic and fresh-keeping antioxidant.

Aloe extract, Flos Lonicerae extract also are domestic generally acknowledged natural plant broad spectrum antimicrobicides, have skin simultaneously and nourish effects such as nursing, antiinflammatory, and be safe in utilization, without any side effects.

Nonoxynolum (NP-9) also is universally recognized always both at home and abroad spermicide.Concentration is that 0.05% NP-9 contact HIV virus makes it deactivation in 60 seconds, and to the toxic effect of the lymphocyte of carrying HIV; The lymphocyte of NP-9 by acting on peplos or being infected by the virus, can suppress HIV-I type viral reverse transcriptase activity, thereby stop it to infect and propagate, can suppress to cause the growth of the pathogen of sexually transmitted disease (STD) (STDS), as gonorrhea, syphilis, trichomonal vaginitis and genital herpes etc.

Vitamin E is the nutrient of generally acknowledging both at home and abroad, has multiple efficacies such as slow down aging, raising immunity, nourishing skin.

As mentioned above, contain materials such as grapefruit seed extract (GSE gold micel), Aloe extract, Flos Lonicerae extract, vitamin E, nonoxynolum in the condom lubricant, be a kind of new method that improves the condom safety, will have promotion potential widely.

The summary of the invention the technical problem to be solved in the present invention be a kind ofly contain multiple antibiotic, sterilization, kill smart, nourish the nursing composition, concrete is the condom that contains grapefruit seed extract (GSE gold micel), Aloe extract, Flos Lonicerae extract, vitamin E and nonoxynolum.

The present invention also provides the production method and the purposes aspect the safety of raising condom thereof of above-mentioned condom.

Technical scheme of the present invention is, based on grapefruit seed extract (GSE gold micel), optionally match with Aloe extract, Flos Lonicerae extract, vitamin E and nonoxynolum, evenly be added in the lubricant, evenly be sprayed on the condom surfaces externally and internally, be prepared into condom with safety.

The present invention does not do specific (special) requirements to condom body production technology, lubricant kind, lubricant spraying coating process.

Lubricant of the present invention (with the 1000ml amount) composed of the following components: grapefruit seed extract (GSE gold micel) 0.01～0.5% is (by containing the 100%GSE conversion; When being lower than 0.01%, be not enough to reach obvious sterilizing effect; Be higher than 0.5%, will increase cost and unnecessary); Aloe extract 2～5 ‰, Flos Lonicerae extract 1～2 ‰, vitamin E 0.1～0.5 ‰, nonoxynolum 0.01～0.05%, lubricant is joined capacity.

The applicant finds, grapefruit seed extract (GSE gold micel) is added in the lubricant of condom, will produce beyond thought anti-bactericidal effect, comprises and kills HIV virus; If carry thing (GSE gold micel) based on the grapefruit seed, and with Aloe extract, Flos Lonicerae extract, vitamin E, nonoxynolum compatibility, add in the condom lubricant, synergistic action effect can be more remarkable.

Wherein grapefruit seed extract (GSE gold micel) can be selected the CITRICIDAL extracting solution (by containing the 100%GSE conversion) that the U.S. (bio/chem) Baeyer health biochemical research is produced for use; Aloe extract is 100% calculating with 100: 1 Aloe gel lyophilized powder, comprises that the aloin of Aloe anthraquinone, aloin must not detect; Flos Lonicerae extract is 100% calculating with the mouth care type extract of chlorogenic acid 4～15%; Vitamin E is selected vitamin E oil for use; Nonoxynolum (NP-9, C ₃₃H ₆₀O ₁₀); The lubricant kind is not done specific (special) requirements, as soluble oil or dimethicone.

The present invention is by organically combining grapefruit seed extract (GSE liquid golden micel), Aloe extract, Flos Lonicerae extract, vitamin E and nonoxynolum, lubricant; evenly be sprayed on the condom surfaces externally and internally, form the molten film of safeguard protection that one deck is antibiotic, sterilize, kill essence, nourishing nursing.In the sexual life process, this special lubricant can evenly be coated skin surface, play antibiotic, sterilization, kill smart, nourish nursing role, even occur breaking in the condom accident, situations such as leakage, slippage, still can play the security protection effect.

The preparation method of condom of the present invention is: will be with grapefruit seed extract (GSE gold micel), or optionally be equipped with Aloe extract, Flos Lonicerae extract, vitamin E and nonoxynolum, pressing component ratio adds in the lubricant, fully mix stirring, homogenizing, adopt condom lubricant spraying coating process evenly to be sprayed on the condom surfaces externally and internally, do not change condom original production, detection, packaging process flow, can make condom of the present invention.

Condom of the present invention has useful safety effect.Because grapefruit seed extract (GSE gold micel), Aloe extract, Flos Lonicerae extract, vitamin E and nonoxynolum, soluble oil and condom body are organically combined, can play the effect that improves safe-sex practices, especially taking place under the fortuitous events such as condom breaks, leakage, slippage, still can effectively suppress, kill various parasites, antibacterial, fungus, virus (comprising various sex desease virus, HIV virus), prevent unexpected gestation and catch; In addition, can also play and nourish nursing skin, amelioration of inflammation (vaginitis, urethritis), eliminate abnormal flavour, protection female genital tract profitable strain balance, the effect that improves immunity, the life-time service effect is better.

Specific implementation method

Embodiment one (in the 1000ml amounts of lubrication):

Grapefruit seed extract (GSE gold micel) 0.1%

Dimethicone is joined sufficient 1000ml

Mentioned component is fully mixed stirring, homogenizing, routinely quantity for spray, evenly be sprayed at the condom surfaces externally and internally, after testing, packing can make condom of the present invention.

Embodiment two (in the 1000ml amounts of lubrication):

Grapefruit seed extract (GSE gold micel) 0.1%

Aloe extract (100: 1 Aloe gel lyophilized powders) 3 ‰

Flos Lonicerae extract (chlorogenic acid 〉=4%) 2 ‰

Vitamin E 0.3 ‰

Nonoxynolum (C ₃₃H ₆₀O ₁₀) 0.05%

Dimethicone is joined sufficient 1000ml

Reference examples (in the 1000ml amounts of lubrication):

Nonoxynolum (C ₃₃H ₆₀O ₁₀) 0.05%

Dimethicone is joined sufficient 1000ml

Mentioned component is fully mixed stirring, homogenizing, routinely quantity for spray, evenly be sprayed at the condom surfaces externally and internally, after testing, packing can make the condom of reference examples.

Correlation test

Experiment one: antibioticly kill smart control experiment

Get 1 of embodiment one condom, 1 of embodiment two condom, 1 of reference examples condom, insert respectively in 3 sterilization test tubes of rubber cap; The suspension that adds the bacteria culture media that approximately contains 30 cells then respectively, the antibacterial that experiment is used has escherichia coli, Salmonella, staphylococcus aureus, all antibacterials all are to isolate from the poultry case, wherein escherichia coli are isolated from system infects, from intestinal, isolate Salmonella, from infected joint, separate obtaining staphylococcus, but these three kinds of antibacterials do not carry out serological Identification; Get the seminal fluid 15ml of healthy male volunteers, and 5ml is added in the above-mentioned sterilization test tube respectively, and add distilled water diluting respectively to 10ml.

At thereafter 0.5,1,5,10,15 and 30 minute, the disinfectant ring immersed in each test tube respectively, took out ring; The small volume of solution that endless belt is gone out is coated onto in the Petri dish on the agar culture medium, culture dish is cultivated 24 hours the variation in the direct observation culture dish under 37 ℃ of conditions.Above-mentioned experiment is resampled, triplicate, record experimental result.The results are shown in following table:

Strain	Time (minute)
	Time (minute)																		???????0.5			?????????1			??????????5			???????????10			???????????15			???????????30
	??A	??B	??C	??A	??B	?C	??A	??B	?C	??A	??B	??C	??A	??B	??C	??A	??B	??C	???????0.5			?????????1			??????????5			???????????10			???????????15			???????????30
	??A	??B	??C	??A	??B	?C	??A	??B	?C	??A	??B	??C	??A	??B	??C	??A	??B	??C	Escherichia coli	??+	??+	??-	??×	??×	?-	??×	??×	?+	??×	??×	??+	??×	??×	??+	??×	??×	??+
Salmonella	??+	??+	??-	??+	??×	?-	??×	??×	?-	??×	??×	??+	??×	??×	??+	??×	??×	??+	Escherichia coli	??+	??+	??-	??×	??×	?-	??×	??×	?+	??×	??×	??+	??×	??×	??+	??×	??×	??+
Salmonella	??+	??+	??-	??+	??×	?-	??×	??×	?-	??×	??×	??+	??×	??×	??+	??×	??×	??+	Staphylococcus aureus	??+	??+	??-	??+	??×	?-	??×	??×	?-	??×	??×	??+	??×	??×	??+	??×	??×	??+
Sperm	??-	??+	??+	??+	??×	?×	??×	??×	?×	??×	??×	??×	??×	??×	??×	??×	??×	??×	Staphylococcus aureus	??+	??+	??-	??+	??×	?-	??×	??×	?-	??×	??×	??+	??×	??×	??+	??×	??×	??+

Annotate: A: represent embodiment one, B: represent embodiment two, C: represent reference examples;

+: representative loses activity, *: representative is killed ,-: represent no abnormal.

Experiment conclusion: from above-mentioned control experiment result, show, in 0.5 and 1 fen clock time, embodiment one shows significant antibacterial activity, reference examples shows the significant smart activity of killing, embodiment two is a compound prescription owing to what adopt, embody synergism, be better than embodiment one, more be better than reference examples; Because the time-to-live of microorganism is shorter relatively in the experiment, this experiment only is the anti-microbial property experiment to the part strain, and embodiment one, two has broad-spectrum antiseptic, bactericidal property (antiviral suppresses Gram-negative and gram-positive bacterium simultaneously, parasiticide and protozoacide).

Experiment two: press down the stripped control experiment of killing the HIV virus activity

Get 1 of embodiment one condom, 1 of embodiment two condom, 1 of reference examples condom, insert respectively in 3 sterilization test tubes of rubber cap; Obtain normal T lymphocyte some (CD4+T accounts for 65%, and CD8+T accounts for 35%) from the volunteer of a health; The HIV virus for preparing high concentration from the upper strata product of HIV CEM production line is some, reverse transcriptase activity (RTA): 1 * 10 ⁶Cpm/ml; T cell and HIV virus are added respectively in the above-mentioned sterilization test tube, and add distilled water diluting to 5ml.

At thereafter 0.5,1,5,10,15 and 30 minute, employing flow cytometry (FCM) method was tested each cell activity and is tested the RTA activity with the Jonassen method of another kind of improvement.Above-mentioned experiment is resampled, triplicate, record experimental result.Results of comparison sees the following form:

Cell type	Time (minute)
	Time (minute)																		????????0.5			??????????1			???????????5			???????????10			????????15			???????????30
	??A	??B	??C	??A	??B	??C	??A	??B	??C	??A	??B	??C	??A	??B	??C	??A	??B	??C	????????0.5			??????????1			???????????5			???????????10			????????15			???????????30
	??A	??B	??C	??A	??B	??C	??A	??B	??C	??A	??B	??C	??A	??B	??C	??A	??B	??C	The T lymphocyte	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-
HIV virus	??+	??+	??-	??×	??×	??+	??×	??×	??+	??×	??×	??×	??×	??×	??×	??×	??×	??×	The T lymphocyte	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-
HIV virus	??+	??+	??-	??×	??×	??+	??×	??×	??+	??×	??×	??×	??×	??×	??×	??×	??×	??×	The RTA activity	??+	??×	??+	??×	??×	??×	??×	??×	??×	??×	??×	??×	??×	??×	??×	??×	??×	??×

Experiment conclusion: show that by above-mentioned control experiment in 0.5 and 1 fen clock time, embodiment one kills HIV virus, kills and be better than reference examples aspect reverse transcription active pressing down; The lubricant of embodiment two is a compound prescription owing to what adopt, has embodied synergism, and effect is because embodiment one more is better than reference examples; Above-mentioned control experiment all has no effect to human body normal immunocyte T lymphocyte, experimental results show that: condom of the present invention can effectively be killed HIV virus, improves the usage safety performance of condom.

Above embodiment and correlation test conclusion only are explanation of the invention, but not limitation of the present invention.

Claims

1, a kind of condom that improves safety is characterized in that containing in the lubricant natural anti-sterilization component grapefruit seed extract (being called for short GSE gold micel).

2, the described a kind of condom that improves safety of claim 1 is characterized in that in the lubricant also containing Aloe extract, Flos Lonicerae extract, vitamin E and nonoxynolum based on grapefruit seed extract (being called for short GSE gold micel).

3, the described a kind of condom that improves safety of claim 1 is characterized in that calculating with the 1000ml lubricant, wherein contains 0.01～0.5% grapefruit seed extract (GSE liquid golden micel).

4, the described a kind of condom that improves safety of claim 2, it is characterized in that calculating with the 1000ml lubricant, wherein contain 0.01～0.5% grapefruit seed extract (GSE liquid golden micel), also contain Aloe extract 2～5 ‰, Flos Lonicerae extract 1～2 ‰, vitamin E 0.1～0.5 ‰, nonoxynolum 0.01～0.05%.

5, any one of claim 1～4 improves the condom of safety, it is characterized in that the type of lubricant is not made particular restriction, and can be dimethicone or soluble oil.

6, any one of claim 1-5 improves the production method of the condom of safety, comprise with each component of lubricant fully mix, after homogenizing stirs, add in the lubricant, evenly be sprayed at the condom surfaces externally and internally, after testing, packing makes condom of the present invention.

7, any one of claim 1-5 improves purposes in the health product of condom aspect preparation improves safety of safety, comprises pressing down and kills sex desease virus, HIV virus, reaches antibiotic, antiinflammatory, kills smart, as to nourish nursing multi-efficiency.