CN1684710A - 包括荧光染料和mri造影剂的双功能造影剂 - Google Patents

包括荧光染料和mri造影剂的双功能造影剂 Download PDF

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Publication number
CN1684710A
CN1684710A CN03822648.0A CN03822648A CN1684710A CN 1684710 A CN1684710 A CN 1684710A CN 03822648 A CN03822648 A CN 03822648A CN 1684710 A CN1684710 A CN 1684710A
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CN
China
Prior art keywords
detection agent
bifunctional
bifunctional detection
magnetic resonance
composition
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Pending
Application number
CN03822648.0A
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English (en)
Chinese (zh)
Inventor
利娜·汉卡
莫汉·M·阿马拉滕加
德尼塞·K·威克特
帕里托什·达瓦尔
内迪姆·艾沙克
费萨尔·A·斯尤德
布鲁斯·F·约翰逊
埃米·C·威廉斯
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General Electric Co
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General Electric Co
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Application filed by General Electric Co filed Critical General Electric Co
Publication of CN1684710A publication Critical patent/CN1684710A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN03822648.0A 2002-09-23 2003-08-11 包括荧光染料和mri造影剂的双功能造影剂 Pending CN1684710A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/252,311 US7303741B2 (en) 2002-09-23 2002-09-23 Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
US10/252,311 2002-09-23

Publications (1)

Publication Number Publication Date
CN1684710A true CN1684710A (zh) 2005-10-19

Family

ID=31992929

Family Applications (1)

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CN03822648.0A Pending CN1684710A (zh) 2002-09-23 2003-08-11 包括荧光染料和mri造影剂的双功能造影剂

Country Status (6)

Country Link
US (2) US7303741B2 (https=)
EP (1) EP1545629A1 (https=)
JP (1) JP2006511473A (https=)
CN (1) CN1684710A (https=)
AU (1) AU2003259769A1 (https=)
WO (1) WO2004026344A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101484794B (zh) * 2006-05-06 2011-02-23 马克思-普朗克科学促进协会 用于试样结构的空间高分辨率成像的方法和荧光显微镜
CN101554481B (zh) * 2009-05-19 2011-04-13 泸州医学院附属医院 用于spect和mri的双功能显像剂及其制备方法
CN102166365A (zh) * 2011-04-25 2011-08-31 东南大学 一种多模态碘油纳米乳造影剂的制备方法
CN102167813A (zh) * 2011-01-19 2011-08-31 兰州大学 一种荧光示踪纳米磁共振成像造影剂
CN107384385A (zh) * 2017-07-31 2017-11-24 中山大学 MR/FL双模态成像探针及其制备方法以及掺杂Ho碳量子点的用途

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ATE536993T1 (de) 2002-01-02 2011-12-15 Visen Medical Inc Aminfunktionalisierte superparamagnetisierte nanoteilchen für die synthese von biokonjugaten
WO2005017539A2 (en) * 2003-08-14 2005-02-24 The General Hospital Corporation Imaging pathology
US20050152842A1 (en) * 2003-12-24 2005-07-14 Chun Li Poly (L-glutamic acid) paramagnetic material complex and use as a biodegradable MRI contrast agent
EP1846042A2 (en) * 2005-01-05 2007-10-24 Board of Regents, The University of Texas System Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
JP2008527119A (ja) 2005-01-13 2008-07-24 シンベンション アーゲー 炭素ナノ粒子を含有する複合材料
FI20055653A7 (fi) * 2005-12-08 2007-06-09 Wallac Oy Leimausreagenssi
WO2007136413A2 (en) 2005-12-22 2007-11-29 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
US20070148094A1 (en) * 2005-12-22 2007-06-28 Uzgiris Egidijus E Polymeric imaging agents and medical imaging methods
AU2007244705A1 (en) * 2006-04-27 2007-11-08 Barnes-Jewish Hospital Detection and imaging of target tissue
CA2692923A1 (en) * 2006-07-03 2008-06-26 Beth Israel Deaconess Medical Center, Inc. Intraoperative imaging methods
US7906106B2 (en) * 2007-06-27 2011-03-15 General Electric Company In vivo cell trafficking
US8021647B2 (en) 2007-06-29 2011-09-20 General Electric Company In vivo optical imaging
CN102159253A (zh) 2008-03-24 2011-08-17 得克萨斯大学体系董事会 心肌病的显像引导的治疗:组合物、制备和用途
WO2009121055A1 (en) * 2008-03-28 2009-10-01 Georgia Tech Research Corporation Reduced dye probes for the detection of radical oxygen species
US8758727B2 (en) * 2008-03-31 2014-06-24 University Of Louisville Research Foundation, Inc. Site specific fluorescence and contrast marker for same
US8440167B2 (en) * 2008-10-27 2013-05-14 University Of Virginia Patent Foundation Multimodal imaging of atherosclerotic plaque targeted to LOX-1
CN102497803B (zh) * 2009-05-05 2015-03-25 卢米托股份有限公司 用于散射介质中改进的扩散发光成像或者断层照相的系统、方法和发光标记物
WO2011109216A2 (en) * 2010-03-01 2011-09-09 University Of Florida Research Foundation, Inc. Nir materials and nanomaterials for theranostic applications
US8834846B2 (en) 2010-05-06 2014-09-16 Bruker Biospin Corporation Fluorescent NIRF activatable probes for disease detection
WO2012047841A2 (en) * 2010-10-04 2012-04-12 Nuovoprobe Ltd. System and method for electromagnetic imaging and therapeutics using specialized nanoparticles
KR101352342B1 (ko) * 2010-11-24 2014-02-17 서울대학교산학협력단 코어 물질과 쉘 물질 사이에 나노갭이 형성된 단일 나노입자 및 이의 제조방법
EP2494936A3 (en) * 2011-03-03 2012-09-19 Imris Inc. MR compatible optical viewing device for use in the bore of an MR magnet
JPWO2012128162A1 (ja) * 2011-03-18 2014-07-24 コニカミノルタ株式会社 画像診断用シリカナノ粒子、その製造方法、及び生体物質標識剤
CN102397562B (zh) * 2011-11-23 2012-11-28 南昌大学 一种由普鲁士蓝负载Gd3+的造影剂的制备方法
US9492571B2 (en) * 2012-06-01 2016-11-15 University Of Massachusetts Molecular probes for multimodality imaging and tracking of stem cells
US9903821B2 (en) 2013-05-01 2018-02-27 Indian Institute Of Technology Madras Coated mesoflowers for molecular detection and smart barcode materials
KR101567157B1 (ko) * 2013-12-13 2015-11-09 경북대학교 산학협력단 Mri/fi 조영제 및 이의 제조방법
US10570173B2 (en) 2015-01-22 2020-02-25 The Board Of Trustees Of The Leland Stanford Junior University Protease-activated contrast agents for in vivo imaging
KR102669535B1 (ko) 2017-03-30 2024-05-24 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 생체 내 이미징을 위한 프로테아제 활성화 조영제
WO2020127154A1 (en) * 2018-12-18 2020-06-25 Bracco Imaging Spa Pharmaceutical compositions comprising gd-complexes and polyarylene additives
CN110665015A (zh) * 2019-10-23 2020-01-10 中山大学 一种肿瘤微环境响应型荧光/磁共振双模态成像探针

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US4899755A (en) * 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
US5900228A (en) * 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US5832931A (en) * 1996-10-30 1998-11-10 Photogen, Inc. Method for improved selectivity in photo-activation and detection of molecular diagnostic agents
US6083486A (en) * 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US6592847B1 (en) 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US6217848B1 (en) 1999-05-20 2001-04-17 Mallinckrodt Inc. Cyanine and indocyanine dye bioconjugates for biomedical applications
IT1318485B1 (it) * 2000-04-21 2003-08-25 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101484794B (zh) * 2006-05-06 2011-02-23 马克思-普朗克科学促进协会 用于试样结构的空间高分辨率成像的方法和荧光显微镜
CN101554481B (zh) * 2009-05-19 2011-04-13 泸州医学院附属医院 用于spect和mri的双功能显像剂及其制备方法
CN102167813A (zh) * 2011-01-19 2011-08-31 兰州大学 一种荧光示踪纳米磁共振成像造影剂
CN102167813B (zh) * 2011-01-19 2012-08-08 兰州大学 一种荧光示踪纳米磁共振成像造影剂
CN102166365A (zh) * 2011-04-25 2011-08-31 东南大学 一种多模态碘油纳米乳造影剂的制备方法
CN102166365B (zh) * 2011-04-25 2012-10-24 东南大学 一种多模态碘油纳米乳造影剂的制备方法
CN107384385A (zh) * 2017-07-31 2017-11-24 中山大学 MR/FL双模态成像探针及其制备方法以及掺杂Ho碳量子点的用途
CN107384385B (zh) * 2017-07-31 2020-10-30 中山大学 MR/FL双模态成像探针及其制备方法以及掺杂Ho碳量子点的用途

Also Published As

Publication number Publication date
WO2004026344A1 (en) 2004-04-01
EP1545629A1 (en) 2005-06-29
US20040057903A1 (en) 2004-03-25
US7303741B2 (en) 2007-12-04
AU2003259769A1 (en) 2004-04-08
US20080118439A1 (en) 2008-05-22
JP2006511473A (ja) 2006-04-06

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