AU2003259769A1 - Bifunctional contrast agent comprising a fluorescent dye and an mri contrast agent - Google Patents

Bifunctional contrast agent comprising a fluorescent dye and an mri contrast agent

Info

Publication number
AU2003259769A1
AU2003259769A1 AU2003259769A AU2003259769A AU2003259769A1 AU 2003259769 A1 AU2003259769 A1 AU 2003259769A1 AU 2003259769 A AU2003259769 A AU 2003259769A AU 2003259769 A AU2003259769 A AU 2003259769A AU 2003259769 A1 AU2003259769 A1 AU 2003259769A1
Authority
AU
Australia
Prior art keywords
contrast agent
fluorescent dye
bifunctional
mri
mri contrast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003259769A
Other languages
English (en)
Inventor
Mohan Mark Amaratunga
Paritosh Dhawale
Lleana Hancu
Nadeem Ishaque
Bruce Fletcher Johnson
Faisal Ahmed Syud
Denyce Kramer Wicht
Amy Casey Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Electric Co
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Electric Co filed Critical General Electric Co
Publication of AU2003259769A1 publication Critical patent/AU2003259769A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2003259769A 2002-09-23 2003-08-11 Bifunctional contrast agent comprising a fluorescent dye and an mri contrast agent Abandoned AU2003259769A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/252,311 US7303741B2 (en) 2002-09-23 2002-09-23 Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
US10/252,311 2002-09-23
PCT/US2003/025184 WO2004026344A1 (en) 2002-09-23 2003-08-11 Bifunctional contrast agent comprising a fluorescent dye and an mri contrast agent

Publications (1)

Publication Number Publication Date
AU2003259769A1 true AU2003259769A1 (en) 2004-04-08

Family

ID=31992929

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003259769A Abandoned AU2003259769A1 (en) 2002-09-23 2003-08-11 Bifunctional contrast agent comprising a fluorescent dye and an mri contrast agent

Country Status (6)

Country Link
US (2) US7303741B2 (https=)
EP (1) EP1545629A1 (https=)
JP (1) JP2006511473A (https=)
CN (1) CN1684710A (https=)
AU (1) AU2003259769A1 (https=)
WO (1) WO2004026344A1 (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE536993T1 (de) 2002-01-02 2011-12-15 Visen Medical Inc Aminfunktionalisierte superparamagnetisierte nanoteilchen für die synthese von biokonjugaten
WO2005017539A2 (en) * 2003-08-14 2005-02-24 The General Hospital Corporation Imaging pathology
US20050152842A1 (en) * 2003-12-24 2005-07-14 Chun Li Poly (L-glutamic acid) paramagnetic material complex and use as a biodegradable MRI contrast agent
EP1846042A2 (en) * 2005-01-05 2007-10-24 Board of Regents, The University of Texas System Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
JP2008527119A (ja) 2005-01-13 2008-07-24 シンベンション アーゲー 炭素ナノ粒子を含有する複合材料
FI20055653A7 (fi) * 2005-12-08 2007-06-09 Wallac Oy Leimausreagenssi
WO2007136413A2 (en) 2005-12-22 2007-11-29 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
US20070148094A1 (en) * 2005-12-22 2007-06-28 Uzgiris Egidijus E Polymeric imaging agents and medical imaging methods
AU2007244705A1 (en) * 2006-04-27 2007-11-08 Barnes-Jewish Hospital Detection and imaging of target tissue
DE102006021317B3 (de) * 2006-05-06 2007-10-11 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren und Fluoreszenzlichtmikroskop zum räumlich hochauflösenden Abbilden einer Struktur einer Probe
CA2692923A1 (en) * 2006-07-03 2008-06-26 Beth Israel Deaconess Medical Center, Inc. Intraoperative imaging methods
US7906106B2 (en) * 2007-06-27 2011-03-15 General Electric Company In vivo cell trafficking
US8021647B2 (en) 2007-06-29 2011-09-20 General Electric Company In vivo optical imaging
CN102159253A (zh) 2008-03-24 2011-08-17 得克萨斯大学体系董事会 心肌病的显像引导的治疗:组合物、制备和用途
WO2009121055A1 (en) * 2008-03-28 2009-10-01 Georgia Tech Research Corporation Reduced dye probes for the detection of radical oxygen species
US8758727B2 (en) * 2008-03-31 2014-06-24 University Of Louisville Research Foundation, Inc. Site specific fluorescence and contrast marker for same
US8440167B2 (en) * 2008-10-27 2013-05-14 University Of Virginia Patent Foundation Multimodal imaging of atherosclerotic plaque targeted to LOX-1
CN102497803B (zh) * 2009-05-05 2015-03-25 卢米托股份有限公司 用于散射介质中改进的扩散发光成像或者断层照相的系统、方法和发光标记物
CN101554481B (zh) * 2009-05-19 2011-04-13 泸州医学院附属医院 用于spect和mri的双功能显像剂及其制备方法
WO2011109216A2 (en) * 2010-03-01 2011-09-09 University Of Florida Research Foundation, Inc. Nir materials and nanomaterials for theranostic applications
US8834846B2 (en) 2010-05-06 2014-09-16 Bruker Biospin Corporation Fluorescent NIRF activatable probes for disease detection
WO2012047841A2 (en) * 2010-10-04 2012-04-12 Nuovoprobe Ltd. System and method for electromagnetic imaging and therapeutics using specialized nanoparticles
KR101352342B1 (ko) * 2010-11-24 2014-02-17 서울대학교산학협력단 코어 물질과 쉘 물질 사이에 나노갭이 형성된 단일 나노입자 및 이의 제조방법
CN102167813B (zh) * 2011-01-19 2012-08-08 兰州大学 一种荧光示踪纳米磁共振成像造影剂
EP2494936A3 (en) * 2011-03-03 2012-09-19 Imris Inc. MR compatible optical viewing device for use in the bore of an MR magnet
JPWO2012128162A1 (ja) * 2011-03-18 2014-07-24 コニカミノルタ株式会社 画像診断用シリカナノ粒子、その製造方法、及び生体物質標識剤
CN102166365B (zh) * 2011-04-25 2012-10-24 东南大学 一种多模态碘油纳米乳造影剂的制备方法
CN102397562B (zh) * 2011-11-23 2012-11-28 南昌大学 一种由普鲁士蓝负载Gd3+的造影剂的制备方法
US9492571B2 (en) * 2012-06-01 2016-11-15 University Of Massachusetts Molecular probes for multimodality imaging and tracking of stem cells
US9903821B2 (en) 2013-05-01 2018-02-27 Indian Institute Of Technology Madras Coated mesoflowers for molecular detection and smart barcode materials
KR101567157B1 (ko) * 2013-12-13 2015-11-09 경북대학교 산학협력단 Mri/fi 조영제 및 이의 제조방법
US10570173B2 (en) 2015-01-22 2020-02-25 The Board Of Trustees Of The Leland Stanford Junior University Protease-activated contrast agents for in vivo imaging
KR102669535B1 (ko) 2017-03-30 2024-05-24 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 생체 내 이미징을 위한 프로테아제 활성화 조영제
CN107384385B (zh) * 2017-07-31 2020-10-30 中山大学 MR/FL双模态成像探针及其制备方法以及掺杂Ho碳量子点的用途
WO2020127154A1 (en) * 2018-12-18 2020-06-25 Bracco Imaging Spa Pharmaceutical compositions comprising gd-complexes and polyarylene additives
CN110665015A (zh) * 2019-10-23 2020-01-10 中山大学 一种肿瘤微环境响应型荧光/磁共振双模态成像探针

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4899755A (en) * 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
US5900228A (en) * 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US5832931A (en) * 1996-10-30 1998-11-10 Photogen, Inc. Method for improved selectivity in photo-activation and detection of molecular diagnostic agents
US6083486A (en) * 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US6592847B1 (en) 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US6217848B1 (en) 1999-05-20 2001-04-17 Mallinckrodt Inc. Cyanine and indocyanine dye bioconjugates for biomedical applications
IT1318485B1 (it) * 2000-04-21 2003-08-25 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari

Also Published As

Publication number Publication date
CN1684710A (zh) 2005-10-19
WO2004026344A1 (en) 2004-04-01
EP1545629A1 (en) 2005-06-29
US20040057903A1 (en) 2004-03-25
US7303741B2 (en) 2007-12-04
US20080118439A1 (en) 2008-05-22
JP2006511473A (ja) 2006-04-06

Similar Documents

Publication Publication Date Title
AU2003259769A1 (en) Bifunctional contrast agent comprising a fluorescent dye and an mri contrast agent
EP1349435B8 (en) Luminescent element and display
AU2002222566A1 (en) Luminescent element and display
AU2002356519A1 (en) Field emission display
AU2003262833A1 (en) Fluorescent glycosides and methods for their use
AU2001288293A1 (en) Scannable barcode display and methods for using the same
AU2003272680A1 (en) Novel green and orange fluorescent labels and their uses
AU2003289463A1 (en) Luminescent body and optical device including the same
AU2003277183A1 (en) Improved diagnostic fluorescence and reflectance
AU2002327185A1 (en) Diagnostic methods and devices
PL355891A1 (en) Near infrared fluorescent contrast agent and fluorescence imaging
AU2002247715A1 (en) Rylene derivatives and their use as dyes
AU7106400A (en) Fluorescent dye angiography and dye-enhanced photocoagulation
AU2002343724A1 (en) Adhesive and use thereof
AU2002366209A1 (en) Visco dye
AU2003213794A1 (en) Pump and tube set thereof
AU2003224912A1 (en) Dyes and fluorescent compounds
AU3568000A (en) Squaraine dyes
AU6835300A (en) Diagnostic kit and use thereof
AU2001291877A1 (en) N-alkoxyalkyl-substituted benzimidazoles and the use thereof as an agent againstparasitic protozoans
AU2003295595A1 (en) Spacer-less field emission display
AU2002361786A1 (en) Emission display device
AU2002350661A1 (en) Diagnostic device and kit
AU2001241102A1 (en) Information display and information providing device
AU2003227058A1 (en) Anthraquinone dyes

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase