CN1683327A - Process for synthesizing dicreatine malic acid - Google Patents
Process for synthesizing dicreatine malic acid Download PDFInfo
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- CN1683327A CN1683327A CN 200510038341 CN200510038341A CN1683327A CN 1683327 A CN1683327 A CN 1683327A CN 200510038341 CN200510038341 CN 200510038341 CN 200510038341 A CN200510038341 A CN 200510038341A CN 1683327 A CN1683327 A CN 1683327A
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- malic acid
- creatine
- sodium
- calcium
- salt
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Abstract
The present invention relates to salt exchange process of synthesizing dicreatine malic acid. The technological process includes the following three steps: neutralization reaction between creatine and hydrochloric acid or sulfuric acid to produce creatine hydrochloride or creatine sulfate, and neutralization reaction between malic acid and sodium hydroxide or calcium hydroxide to produce sodium salt or calcium salt of malic acid; exchange reaction between creatine hydrochloride or creatine sulfate and sodium salt or calcium salt of malic acid to produce dicreatine malic acid and sodium chloride/calcium chloride or sodium sulfate/calcium sulfate; and membrane separation to eliminate sodium chloride/calcium chloride and to obtain filtrate, concentration, dewatering and stoving to obtain dicreatine malic acid product with high quality and purity over 99.8 %.
Description
Technical field:
The present invention relates to a kind of method of synthesizing dicreatine malic acid.Belong to field of chemical technology.
Background technology:
Dicreatine malic acid is a kind of novel health food raw material, and is very wide in American-European countries's market outlook.Annual from China's this product of a large amount of imports, but all be with two creatines and oxysuccinic acid by 2: 1 mixed after export trade.Because two kinds of composition impurities differences are so quality is difficult to be guaranteed.
Summary of the invention:
The objective of the invention is to overcome above-mentioned deficiency, a kind of method of producing the dicreatine malic acid of synthetic level is provided.
The object of the present invention is achieved like this: a kind of method of synthesizing dicreatine malic acid, its processing step divided for three steps carried out:
The first step,
A) make creatine and hydrochloric acid or sulfuric acid generation neutralization reaction, generate creatine hydrochloride/creatine vitriol, reaction equation:
B) make oxysuccinic acid and sodium hydroxide or calcium hydroxide generation neutralization reaction, generate oxysuccinic acid sodium salt/oxysuccinic acid calcium salt, reaction equation:
Second goes on foot, makes creatine hydrochloride/creatine vitriol and oxysuccinic acid sodium salt/oxysuccinic acid calcium salt generation permutoid reaction, generates dicreatine malic acid and sodium-chlor/calcium chloride or sodium sulfate/calcium sulfate, reaction equation:
The 3rd step, separate the concentrating filter liquor dehydration that obtains behind contained inorganic salt sodium-chlor/calcium chloride with infiltrate membrane technology, oven dry promptly obtains the dicreatine malic acid finished product.
Because the present invention adopts the salt exchange process to come synthesizing dicreatine malic acid, makes the quality of dicreatine malic acid be guaranteed, purity is not less than 99.8%.
Embodiment:
The present invention is a kind of method of synthesizing dicreatine malic acid, and it is to adopt the salt exchange process to come synthesizing dicreatine malic acid, and its processing step divided for three steps carried out:
The first step,
A) make creatine and hydrochloric acid or sulfuric acid generation neutralization reaction, generate creatine hydrochloride/creatine vitriol,
B) make oxysuccinic acid and sodium hydroxide or calcium hydroxide generation neutralization reaction, generate oxysuccinic acid sodium salt/oxysuccinic acid calcium salt;
Second goes on foot, makes creatine hydrochloride/creatine vitriol and oxysuccinic acid sodium salt/oxysuccinic acid calcium salt generation permutoid reaction, generates dicreatine malic acid and sodium-chlor/calcium chloride or sodium sulfate/calcium sulfate;
The 3rd step, separate contained inorganic salt sodium-chlor/calcium chloride with infiltrate membrane technology after (but sodium sulfate/calcium direct filtration is separated) concentrating filter liquor dehydration of obtaining, oven dry promptly obtains the dicreatine malic acid finished product.
Claims (1)
1, a kind of method of synthesizing dicreatine malic acid is characterized in that adopting the salt exchange process to come synthesizing dicreatine malic acid, and its processing step divided for three steps carried out:
The first step,
A) make creatine and hydrochloric acid or sulfuric acid generation neutralization reaction, generate creatine hydrochloride/creatine vitriol, reaction equation:
B) make oxysuccinic acid and sodium hydroxide or calcium hydroxide generation neutralization reaction, generate oxysuccinic acid sodium salt/oxysuccinic acid calcium salt, reaction equation:
Second goes on foot, makes creatine hydrochloride/creatine vitriol and oxysuccinic acid sodium salt/oxysuccinic acid calcium salt generation permutoid reaction, generates dicreatine malic acid and sodium-chlor/calcium chloride or sodium sulfate/calcium sulfate, reaction equation:
The 3rd goes on foot, separates with infiltrate membrane technology and remove the concentrating filter liquor dehydration that obtains behind contained inorganic salt sodium-chlor/calcium chloride, and oven dry promptly obtains the dicreatine malic acid finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100383419A CN1321108C (en) | 2005-02-07 | 2005-02-07 | Process for synthesizing dicreatine malic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100383419A CN1321108C (en) | 2005-02-07 | 2005-02-07 | Process for synthesizing dicreatine malic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1683327A true CN1683327A (en) | 2005-10-19 |
| CN1321108C CN1321108C (en) | 2007-06-13 |
Family
ID=35262854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100383419A Expired - Fee Related CN1321108C (en) | 2005-02-07 | 2005-02-07 | Process for synthesizing dicreatine malic acid |
Country Status (1)
| Country | Link |
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| CN (1) | CN1321108C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102391156A (en) * | 2011-09-07 | 2012-03-28 | 沈军 | Preparation method of guanidine derivative creatine hydrochloride |
| CN103319376A (en) * | 2013-06-21 | 2013-09-25 | 太仓市新毛涤纶化工有限公司 | Preparation method of creatine hydrochloride |
| CN110241147A (en) * | 2019-07-05 | 2019-09-17 | 安徽丰原发酵技术工程研究有限公司 | A kind of method of fermenting and producing L MALIC ACID coproduction succinic acid |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040077902A1 (en) * | 2002-10-18 | 2004-04-22 | Llewellyn William Charles | Dicreatine maleate and method for making same |
| US7129273B2 (en) * | 2003-04-30 | 2006-10-31 | Creative Compounds, Llc | Dicreatine Malate |
-
2005
- 2005-02-07 CN CNB2005100383419A patent/CN1321108C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102391156A (en) * | 2011-09-07 | 2012-03-28 | 沈军 | Preparation method of guanidine derivative creatine hydrochloride |
| CN102391156B (en) * | 2011-09-07 | 2013-11-27 | 沈军 | Preparation method of guanidine derivative creatine hydrochloride |
| CN103319376A (en) * | 2013-06-21 | 2013-09-25 | 太仓市新毛涤纶化工有限公司 | Preparation method of creatine hydrochloride |
| CN103319376B (en) * | 2013-06-21 | 2015-11-18 | 太仓市新毛涤纶化工有限公司 | The preparation method of creatine hydrochloride |
| CN110241147A (en) * | 2019-07-05 | 2019-09-17 | 安徽丰原发酵技术工程研究有限公司 | A kind of method of fermenting and producing L MALIC ACID coproduction succinic acid |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1321108C (en) | 2007-06-13 |
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