CN1321108C - Process for synthesizing dicreatine malic acid - Google Patents
Process for synthesizing dicreatine malic acid Download PDFInfo
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- CN1321108C CN1321108C CNB2005100383419A CN200510038341A CN1321108C CN 1321108 C CN1321108 C CN 1321108C CN B2005100383419 A CNB2005100383419 A CN B2005100383419A CN 200510038341 A CN200510038341 A CN 200510038341A CN 1321108 C CN1321108 C CN 1321108C
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- China
- Prior art keywords
- malic acid
- sodium
- calcium
- creatine
- salt
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Abstract
The present invention relates to a method for synthesizing dicreatine malic acid, which is characterized in that the dicreatine malic acid is synthesized in a salt exchange method. The method comprises three steps that (1), creatine and hydrochloric acid or sulfuric acid carry out a neutralization reaction, and creatine hydrochloride or creatine sulphate is generated; malic acid and sodium hydrate or calcium hydroxide carry out a neutralization reaction, and malic acid sodium or malic acid calcium salt is generated; (2), the creatine hydrochloride or the creatine sulphate and the malic acid sodium or the malic acid calcium salt carry out an exchange reaction, and dicreatine malic acid and sodium chloride or calcium chloride or sodium sulfate or calcium sulphate are generated; (3), a filtered solution obtained is concentrated and dewatered after inorganic salt sodium chloride or inorganic salt calcium chloride is separated and removed by an osmotic membrane technique, and a finished product of the dicreatine malic acid is obtained through drying. Because the dicreatine malic acid is synthesized in a salt exchange method, the present invention has the advantages that the quality of the dicreatine malic acid is ensured, and the purity is not less than 99.8%.
Description
Technical field:
The present invention relates to a kind of method of synthesizing dicreatine malic acid.Belong to field of chemical technology.
Background technology:
Dicreatine malic acid is a kind of novel health food raw material, and is very wide in American-European countries's market outlook.Annual from China's this product of a large amount of imports, but all be with two creatines and oxysuccinic acid by 2: 1 mixed after export trade.Because two kinds of composition impurities differences are so quality is difficult to be guaranteed.
Summary of the invention:
The objective of the invention is to overcome above-mentioned deficiency, a kind of method of producing the dicreatine malic acid of synthetic level is provided.
The object of the present invention is achieved like this: a kind of method of synthesizing dicreatine malic acid, its processing step divided for three steps carried out:
The first step,
A) make creatine and hydrochloric acid or sulfuric acid generation neutralization reaction, generate creatine hydrochloride/creatine vitriol, reaction equation:
HN＝C-N-CH
2COOH+HCl→HCl·HN＝C-N-CH
2COOH
|?| |?|
H
2N?CH
2 H
2N?CH
2
B) make oxysuccinic acid and sodium hydroxide or calcium hydroxide generation neutralization reaction, generate oxysuccinic acid sodium salt/oxysuccinic acid calcium salt, reaction equation:
HO-CH-COOH+2NaOH→HO-CH-COONa+2H
2O
| |
CH
2-COOH CH
2-COONa
Second goes on foot, makes creatine hydrochloride/creatine vitriol and oxysuccinic acid sodium salt/oxysuccinic acid calcium salt generation permutoid reaction, generates dicreatine malic acid and sodium-chlor/calcium chloride or sodium sulfate/calcium sulfate, reaction equation:
2HCl·HN＝C-N-CH
2COOH+HO-CH-COONa→2NaCl+
|?| |
H
2N?CH
2 CH
2-COONa
H
2N?CH
2
|?|
HO-CH-COOH·HN＝C-N-CH
2COOH
|
CH
2-COOH·HN＝C-N-CH
2COOH
|?|
H
2N?CH
3
The 3rd step, separate the concentrating filter liquor dehydration that obtains behind contained inorganic salt sodium-chlor/calcium chloride with infiltrate membrane technology, oven dry promptly obtains the dicreatine malic acid finished product.
Because the present invention adopts the salt exchange process to come synthesizing dicreatine malic acid, makes the quality of dicreatine malic acid be guaranteed, purity is not less than 99.8%.
Embodiment:
The present invention is a kind of method of synthesizing dicreatine malic acid, and it is to adopt the salt exchange process to come synthesizing dicreatine malic acid, and its processing step divided for three steps carried out:
The first step,
A) make creatine and hydrochloric acid or sulfuric acid generation neutralization reaction, generate creatine hydrochloride/creatine vitriol,
B) make oxysuccinic acid and sodium hydroxide or calcium hydroxide generation neutralization reaction, generate oxysuccinic acid sodium salt/oxysuccinic acid calcium salt;
Second goes on foot, makes creatine hydrochloride/creatine vitriol and oxysuccinic acid sodium salt/oxysuccinic acid calcium salt generation permutoid reaction, generates dicreatine malic acid and sodium-chlor/calcium chloride or sodium sulfate/calcium sulfate;
The 3rd step, separate contained inorganic salt sodium-chlor/calcium chloride with infiltrate membrane technology after (but sodium sulfate/calcium direct filtration is separated) concentrating filter liquor dehydration of obtaining, oven dry promptly obtains the dicreatine malic acid finished product.
Claims (1)
1, a kind of method of synthesizing dicreatine malic acid is characterized in that adopting the salt exchange process to come synthesizing dicreatine malic acid, and its processing step divided for three steps carried out:
The first step,
A) make creatine and hydrochloric acid or sulfuric acid generation neutralization reaction, generate creatine hydrochloride/creatine vitriol,
B) make oxysuccinic acid and sodium hydroxide or calcium hydroxide generation neutralization reaction, generate oxysuccinic acid sodium salt/oxysuccinic acid calcium salt,
Second goes on foot, makes creatine hydrochloride/creatine vitriol and oxysuccinic acid sodium salt/oxysuccinic acid calcium salt generation permutoid reaction, generates dicreatine malic acid and sodium-chlor/calcium chloride or sodium sulfate/calcium sulfate,
The 3rd step, direct filtration separating sodium sulfate/calcium sulfate are removed the concentrating filter liquor dehydration that obtains behind contained inorganic salt sodium-chlor/calcium chloride with the infiltrate membrane technology separation, and oven dry promptly obtains the dicreatine malic acid finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100383419A CN1321108C (en) | 2005-02-07 | 2005-02-07 | Process for synthesizing dicreatine malic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100383419A CN1321108C (en) | 2005-02-07 | 2005-02-07 | Process for synthesizing dicreatine malic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1683327A CN1683327A (en) | 2005-10-19 |
| CN1321108C true CN1321108C (en) | 2007-06-13 |
Family
ID=35262854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100383419A Expired - Fee Related CN1321108C (en) | 2005-02-07 | 2005-02-07 | Process for synthesizing dicreatine malic acid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1321108C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102391156B (en) * | 2011-09-07 | 2013-11-27 | 沈军 | Preparation method of guanidine derivative creatine hydrochloride |
| CN103319376B (en) * | 2013-06-21 | 2015-11-18 | 太仓市新毛涤纶化工有限公司 | The preparation method of creatine hydrochloride |
| CN110241147B (en) * | 2019-07-05 | 2022-02-25 | 安徽丰原发酵技术工程研究有限公司 | Method for co-producing succinic acid by fermenting L-malic acid |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040077902A1 (en) * | 2002-10-18 | 2004-04-22 | Llewellyn William Charles | Dicreatine maleate and method for making same |
| US20040220263A1 (en) * | 2003-04-30 | 2004-11-04 | Creative Compunds, Llc | Dicreatine Malate |
-
2005
- 2005-02-07 CN CNB2005100383419A patent/CN1321108C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040077902A1 (en) * | 2002-10-18 | 2004-04-22 | Llewellyn William Charles | Dicreatine maleate and method for making same |
| US20040220263A1 (en) * | 2003-04-30 | 2004-11-04 | Creative Compunds, Llc | Dicreatine Malate |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1683327A (en) | 2005-10-19 |
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