CN1672702A - Compound liver-nourishing ant tablet and bolus - Google Patents
Compound liver-nourishing ant tablet and bolus Download PDFInfo
- Publication number
- CN1672702A CN1672702A CNA2004100144790A CN200410014479A CN1672702A CN 1672702 A CN1672702 A CN 1672702A CN A2004100144790 A CNA2004100144790 A CN A2004100144790A CN 200410014479 A CN200410014479 A CN 200410014479A CN 1672702 A CN1672702 A CN 1672702A
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- Prior art keywords
- tablet
- nourishing
- ant
- herba artemisiae
- liver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000000843 powder Substances 0.000 claims abstract description 17
- 210000004185 liver Anatomy 0.000 claims abstract description 13
- 238000002360 preparation method Methods 0.000 claims abstract description 12
- 239000000341 volatile oil Substances 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000706 filtrate Substances 0.000 claims abstract description 7
- 241000202807 Glycyrrhiza Species 0.000 claims abstract description 6
- 239000006228 supernatant Substances 0.000 claims abstract description 6
- 239000011248 coating agent Substances 0.000 claims abstract description 4
- 238000000576 coating method Methods 0.000 claims abstract description 4
- 239000003814 drug Substances 0.000 claims description 23
- 241001251068 Formica fusca Species 0.000 claims description 20
- 229940079593 drug Drugs 0.000 claims description 11
- 239000006187 pill Substances 0.000 claims description 11
- 239000007864 aqueous solution Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 4
- 238000009495 sugar coating Methods 0.000 claims description 4
- 238000005498 polishing Methods 0.000 claims description 3
- 241001529553 Scoparia <angiosperm> Species 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 238000011049 filling Methods 0.000 claims 1
- 238000007670 refining Methods 0.000 claims 1
- -1 sieves Substances 0.000 claims 1
- 238000001256 steam distillation Methods 0.000 claims 1
- 230000008901 benefit Effects 0.000 abstract description 3
- 210000003734 kidney Anatomy 0.000 abstract description 2
- 235000008658 Artemisia capillaris Nutrition 0.000 abstract 3
- 241000092668 Artemisia capillaris Species 0.000 abstract 3
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 2
- 244000241838 Lycium barbarum Species 0.000 abstract 2
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 2
- 235000015468 Lycium chinense Nutrition 0.000 abstract 2
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 229940010454 licorice Drugs 0.000 abstract 2
- 238000007873 sieving Methods 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 description 8
- 230000000694 effects Effects 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000004821 distillation Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 241000700605 Viruses Species 0.000 description 3
- 241000700721 Hepatitis B virus Species 0.000 description 2
- 206010058117 Ocular icterus Diseases 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 210000000088 lip Anatomy 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 229940071462 oralone Drugs 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical group CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 208000000419 Chronic Hepatitis B Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000012372 quality testing Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The compound liver-nourishing ant tablet and bolus for nourishing liver, invigorating kidney and clearing away wetness and heat is prepared with ant, capillary artemisia, wolfberry fruit and licorice as material. The preparation process includes crushing and sieving ant and licorice to form fine powder; extracting capillary artemisia to obtain volatile oil and water solution; twice decocting capillary artemisia dreg and wolfberry fruit and filtering to obtain filtrate; merging the water solution and the filtrate, concentrating to density of 1.10, adding alcohol, letting stand for night and concentrating the supernatant to obtain extractum of density 1.38-1.40; adding the fine powder, drying, crushing, sieving, spraying the volatile oil, mixing, tabletting and coating sugar to form tablet, or adding supplementary material to obtain bolus. The present invention has the advantages of fast acting, high bioavailability, etc.
Description
Technical field
The present invention relates to a kind of liver-nourishing kidney-boosting that is used for, the tablet of eliminating damp-heat.Be applicable to that the chronic hepatitis B caused by liver and kidney deficiency has damp and hot patient concurrently, to the icteric sclera yellowish urine, hepatalgia, poor appetite is weak, and gastral cavity is vexed, and symptom such as feel sick has the improvement effect.
Background technology
10 Chinese just have a people to carry hepatitis B virus, and 100 philtrums have only a people to understand hepatitis B.1.2 hundred million people's virus carrier, 2,000 ten thousand people's chronic viral hepatitis B patient, the popular present situation of the present hepatitis B of China of Ministry of Public Health issue in this year that Here it is.And annual therefore sick and dead people nearly 500,000.
Hepatitis B is one of chronic disease that has potential lethal, and China is hepatitis B big country, and per 10 philtrums just have one to be the virus carrier, wherein has 1/4th carrier will finally develop into end-age cirrhosis and hepatocarcinoma approximately.There are nearly 700,000,000 Chinese to infect hepatitis B virus.The medicine of treatment hepatitis B is a lot of at present, cures the symptoms, not the disease mostly, and therefore, the relapse rate of hepatitis B is very high.
Summary of the invention
The present invention is the theory of Chinese medical science angle from liver protecting and nourishing, provides a kind of liver-nourishing kidney-boosting that is used for, the Chinese medicine of eliminating damp-heat.
Another object of the present invention provides the preparation method of this Chinese medicinal tablet and pill.
Medicament selection Formica fusca of the present invention, Herba Artemisiae Scopariae, Fructus Lycii, Radix Glycyrrhizae are that crude drug carries out compatible combination, make each efficacy of drugs produce synergism, thus effective liver-nourishing kidney-boosting, eliminating damp-heat.Wherein, the Formica fusca reinforcing body resistance improves the autoimmune ability, eliminating evil going out, and the removing hepatitis virus is a monarch drug; The removing damp-heat from the liver and the gallbladder of compatibility Herba Artemisiae Scopariae, transaminase lowering are ministerial drug, and assistant protects the liver with the Fructus Lycii nourishing the liver, makes with the Radix Glycyrrhizae the spleen and stomach regulating.Chu's medicine compatibility, reinforcing and reducing are also executed, and reach the purpose of liver heat removing nourishing the liver strengthening vital QI to eliminate pathogenic factors, have the invigorating middle warmer residence to rush down, the meaning of residence benefit in loosing, the Therapeutic Principle who has demonstrated fully the traditional Chinese medical science " strengthening vital QI to eliminate pathogenic factors ".
The consumption of drug component of the present invention is groped to sum up to draw through the inventor in a large number, and each amounts of components all has better curative effect in the following weight parts scope.
Formica fusca: 1～2 part in 2～4 portions of Radix Glycyrrhizaes of 4～5 parts of Fructus Lycii of 1～3 portion of Herba Artemisiae Scopariae
Above-mentioned formula optimization is:
Formica fusca: 1 part in 3 portions of Radix Glycyrrhizaes of 4.5 parts of Fructus Lycii of 2 portions of Herba Artemisiae Scopariaes
Medicine of the present invention has the conventional method that can adopt Chinese medicine preparation to be prepared into any conventional oral preparations.But,, preferably the Herba Artemisiae Scopariae in the crude drug is carried out vapor extraction volatilization wet goods, but these do not limit protection scope of the present invention for each raw material that makes this medicine is better brought into play drug effect.
The preparation method of preferred for preparation tablet of the present invention:
(1) takes by weighing raw material for standby in proportion;
(2) Formica fusca, the Radix Glycyrrhizae powder with described weight proportion is broken into smalls, sieves;
(3) the Herba Artemisiae Scopariae vapor distillation is extracted volatile oil, aqueous solution saves as;
(4) medicinal residues and Fructus Lycii are added 8 times of water gagings decoction secondaries, each 2 hours;
(5) collecting decoction filters, and filtrate merges with above-mentioned aqueous solution, is concentrated into relative density 1.10 (60～80 ℃), adds ethanol and makes and contain alcohol and measure and reach 60%, standing over night;
(6) get supernatant and reclaim ethanol and be concentrated into relative density 1.38-11.40 (60～80 ℃) thick paste shape, add Formica fusca, Radix Glycyrrhizae fine powder; Mixing is dried and crushed into smalls, sieves, and spray is with Herba Artemisiae Scopariae volatile oil, mixing, the active component of medicine of the present invention
(7) active component and tablet adjuvant commonly used is mixed, tabletting, the tablet of sugar coating, or active component added to produce in right amount make ball, dry, black grey coating, polishing gets pill.
That tablet provided by the invention, pill dosage form, its advantage are is rapid-action, bioavailability is high, take with easy to carry, mouthfeel good, can carry out the quality testing of qualitative, quantitative, good stability.
The specific embodiment
Below in conjunction with the further auspicious preparation method of stating medicine of the present invention of embodiment.
The preparation tablets of embodiment 1 medicine of the present invention
Prescription:
Formica fusca: 200g Herba Artemisiae Scopariae: 450g Fructus Lycii: 300g Radix Glycyrrhizae: 100g
Method for making:
(1) get Formica fusca, Radix Glycyrrhizae powder is broken into fine powder, sieve;
(2) the Herba Artemisiae Scopariae vapor distillation is extracted volatile oil, aqueous solution is preserved in addition;
(3) medicinal residues and Fructus Lycii add 8 times of water gagings decoction secondaries, each 2 hours;
(4) collecting decoction filters, and filtrate merges with above-mentioned aqueous solution, is concentrated into relative density 1.10 (60～80 ℃), adds ethanol and makes and contain alcohol and measure and reach 60%, standing over night;
(5) get supernatant and reclaim ethanol and be concentrated into relative density 1.38-11.40 (60～80 ℃) thick paste shape, add Formica fusca, Radix Glycyrrhizae fine powder; Mixing is dried and crushed into smalls, sieves, and sprays with Herba Artemisiae Scopariae volatile oil mixing;
(6) sugar coating sheet behind the tabletting, the every 1.05g of plate core weight.
Embodiment 2
Prescription:
Formica fusca: 250g Herba Artemisiae Scopariae: 400g Fructus Lycii: 250g Radix Glycyrrhizae: 150g
Method for making:
(1) preparation method be get Formica fusca, Radix Glycyrrhizae powder is broken into fine powder, sieve:
(2) the Herba Artemisiae Scopariae vapor distillation is extracted volatile oil, water liquid is preserved in addition;
(3) medicinal residues and Fructus Lycii add 8 times of water gagings decoction secondaries, each 2 hours;
(4) collecting decoction filters, and filtrate merges with above-mentioned aqueous solution, is concentrated into relative density 1.10 (60～80 ℃), adds ethanol and makes and contain alcohol and measure and reach 60%, standing over night;
(5) get supernatant and reclaim ethanol and be concentrated into relative density 1.38-11.40 (60～80 ℃) thick paste shape, add Formica fusca, Radix Glycyrrhizae fine powder; Mixing is dried and crushed into smalls, sieves, and sprays with Herba Artemisiae Scopariae volatile oil mixing;
(6) sugar coating sheet behind the tabletting, the every 1.05g of plate core weight.
The pill preparation of embodiment 3 medicines of the present invention
Prescription:
Formica fusca: 200g Herba Artemisiae Scopariae: 450g Fructus Lycii: 300g Radix Glycyrrhizae: 100g
Method for making:
(1) get Formica fusca, Radix Glycyrrhizae powder is broken into fine powder, sieve;
(2) the Herba Artemisiae Scopariae vapor distillation is extracted volatile oil, aqueous solution is preserved in addition;
(3) medicinal residues and Fructus Lycii add 8 times of water gagings decoction secondaries, each 2 hours;
(4) collecting decoction filters, and filtrate merges with above-mentioned aqueous solution, is concentrated into relative density 1.10 (60～80 ℃), adds ethanol and makes and contain alcohol and measure and reach 60%, standing over night;
(5) getting supernatant reclaims ethanol and is concentrated into relative density 1.38-11.40 (60～80 ℃) thick paste;
(6) add Formica fusca, Radix Glycyrrhizae fine powder, mixing adds an amount of refined honey pill, and oven dry is sprayed with Herba Artemisiae Scopariae volatile oil, black grey coating, and polishing promptly gets complex ant live-nourishing ' yanggan ' pill preparation.Ball heavily is equivalent to the 1.05g (oral one time 4 ball, 3 times on the one) of raw medicinal herbs
Embodiment 4
Assay:
Total nitrogen is measured this product 0.1g, and accurate the title decides, and measures according to N2 method (2000 editions one appendix IXI second method of The People's Republic of China's pharmacopeia).
This product contains total nitrogen (N) should be no less than 2.0%.
Embodiment 5
The test example
Further illustrate effective effect below in conjunction with the test example.
1 physical data
Clinical treatment patient 30 examples, wherein male 9 examples, women 21 examples.Age 20-40 year 12 examples, 18 examples more than 40 years old.
2 tcm diagnosis symptoms
The icteric sclera yellowish urine, hepatalgia, poor appetite is weak, and gastral cavity is vexed feels sick
3 Therapeutic Method
Medicine: complex ant nourishing the liver coated tablet
Instructions of taking: oral one time 4,3 times on the one
Treatment time: fixed according to the state of an illness, generally take two weeks-2 month
4 efficacy assessment standards
Produce effects: transference cure, observe 2 months health status and stablize.
Effectively: symptom has obviously and alleviates.
Invalid: as not reach effective standard.
5 therapeutic effect
Produce effects: 70%
Effectively: 30%
Invalid: 0%
Total effective rate: 100%
Claims (4)
1, a kind of complex ant nourishing the liver tablet and pill is characterized in that it is made by following bulk drugs:
Formica fusca: 1～2 part in 2～4 portions of Radix Glycyrrhizaes of 4～5 parts of Fructus Lycii of 1～3 portion of Herba Artemisiae Scopariae
2, complex ant nourishing the liver tablet according to claim 1 and pill is characterized in that the preferred proportion of filling a prescription is:
Formica fusca: 1 part in 3 portions of Radix Glycyrrhizaes of 4.5 parts of Fructus Lycii of 2 portions of Herba Artemisiae Scopariaes
3, a kind of method for preparing claim 1 or 2 described complex ant nourishing the liver tablets and pill, its step is as follows:
(1) take by weighing each crude drug Formica fusca, Herba Artemisiae Scopariae, structure Fructus Lycii, Radix Glycyrrhizae, standby;
(2) Formica fusca, the Radix Glycyrrhizae powder with described weight proportion is broken into fine powder, sieves, and be standby;
(3) with the Herba Artemisiae Scopariae steam distillation, extract volatile oil, aqueous solution is preserved in addition;
(4) step 2 medicinal residues and Fructus Lycii are decocted with water secondary;
(5) collecting decoction filters, and filtrate and step (2) aqueous solution merges, and is concentrated into relative density 1.10 (60～80 ℃), adds ethanol and makes and contain alcohol and measure and reach 60%, standing over night;
(6) get supernatant and reclaim ethanol and be concentrated into relative density 1.38-11.40 (60～80 ℃) thick paste shape, add Formica fusca, Radix Glycyrrhizae fine powder; Mixing is dried and crushed into fine powder, sieves, and spray is with Herba Artemisiae Scopariae volatile oil, mixing, the active component of medicine of the present invention;
(7) active component of step (6) gained is mixed with tablet adjuvant commonly used, tabletting, sugar coating gets tablet; Or active component added the close ball of making of an amount of refining, and oven dry, black grey coating, polishing gets pill.
4, according to the preparation method of the described medicine of claim 3, when it is characterized in that in the step (5) medicine decocted with water, secondary adds water and is 8 times of amounts, and decocting time is 2 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100144790A CN100341542C (en) | 2004-03-26 | 2004-03-26 | Compound liver-nourishing ant tablet and bolus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100144790A CN100341542C (en) | 2004-03-26 | 2004-03-26 | Compound liver-nourishing ant tablet and bolus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1672702A true CN1672702A (en) | 2005-09-28 |
| CN100341542C CN100341542C (en) | 2007-10-10 |
Family
ID=35045644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100144790A Expired - Lifetime CN100341542C (en) | 2004-03-26 | 2004-03-26 | Compound liver-nourishing ant tablet and bolus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100341542C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266307A (en) * | 2016-08-31 | 2017-01-04 | 单晓春 | Formica fusca bear gall pill and its preparation method and application |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1136881C (en) * | 2001-02-19 | 2004-02-04 | 孟庆云 | Combined Chinese and Western medicine for treating pulmonary emphysema |
| CN1493315A (en) * | 2002-10-31 | 2004-05-05 | 陈瑞林 | Medicine for treating chronic hepatitis B |
-
2004
- 2004-03-26 CN CNB2004100144790A patent/CN100341542C/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266307A (en) * | 2016-08-31 | 2017-01-04 | 单晓春 | Formica fusca bear gall pill and its preparation method and application |
| CN106266307B (en) * | 2016-08-31 | 2019-11-19 | 单晓春 | Ant bear gall pill and its preparation method and application |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100341542C (en) | 2007-10-10 |
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Owner name: JIANGSU EHAI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: ZHANG YANJUN Effective date: 20120502 |
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Free format text: CORRECT: ADDRESS; FROM: 221000 XUZHOU, JIANGSU PROVINCE TO: 221004 XUZHOU, JIANGSU PROVINCE |
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Effective date of registration: 20120502 Address after: 221004 No. 18 Yang Shan Road, Xuzhou Economic Development Zone, Xuzhou, Jiangsu Patentee after: JIANGSU YI SEA PHARMACEUTICAl Co.,Ltd. Address before: 221000, Jiangsu province Xuzhou Lantau Peak Kang residence area B7 building 403 rooms, Zhang Weifang turn Patentee before: Zhang Yanjun |
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Denomination of invention: A kind of compound ant liver nourishing tablet and pill Effective date of registration: 20220914 Granted publication date: 20071010 Pledgee: Bank of Communications Co.,Ltd. Xuzhou Branch Pledgor: JIANGSU YI SEA PHARMACEUTICAl Co.,Ltd. Registration number: Y2022320000538 |
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