CN1665546A - 特别用于椎间盘突出治疗的药物制剂 - Google Patents
特别用于椎间盘突出治疗的药物制剂 Download PDFInfo
- Publication number
- CN1665546A CN1665546A CN038129361A CN03812936A CN1665546A CN 1665546 A CN1665546 A CN 1665546A CN 038129361 A CN038129361 A CN 038129361A CN 03812936 A CN03812936 A CN 03812936A CN 1665546 A CN1665546 A CN 1665546A
- Authority
- CN
- China
- Prior art keywords
- preparation
- ethanol
- chemical compound
- formulation
- ethyl cellulose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
产品 | 商品名 | 供应商 |
羟基纤维素 | Klucel MF EP | Aldrich |
Klucel HF EP | ||
乙基纤维素 | Aqualon 100NF | Hercules |
聚山梨醇酯 | Montanox 80 | Seppic |
硅胶 | Aérosil R972 | Degussa France |
Aérosil R200 | ||
羧基聚亚甲基 | Carbopol 940 | Gattefosse |
Carbopol 934 | ||
聚乙二醇 | Lutrol E4000 | BASF France |
Lutrol E6000 |
产品 | 乙醇中的溶解度 | 视觉检查 | |
冷 | 热 | ||
羟丙基纤维素 | - | + | 冷却后不均一 |
- | + | ||
乙基纤维素 | ± | + | 澄明的凝胶 |
聚山梨醇酯 | - | + | 粘度很低 |
硅胶 | - | + | 几天后才变得有粘性 |
- | + | ||
羧基聚亚甲基 | - | + | 中和后沉淀 |
- | + | ||
聚乙二醇 | - | + | 冷却沉淀 |
- | + |
数据 | C乙醇(g·L-1) | Véch(mL) | Wech(g) | Dech(g·mL-1) | 干燥残渣DR(g) | DR/Wech比率(%) | 粘度(cp)* |
D1 | 784 | 2 | 1.650 | 0.825 | 0.101 | 6.10 | 320 |
D8 | 821 | 2 | 1.720 | 0.850 | 0.103 | 5.97 | 339.5 |
D15 | 783 | 2 | 1.610 | 0.800 | 0.097 | 6.00 | - |
D30 | 820 | 2 | 1.670 | 0.830 | 0.099 | 5.92 | 332 |
平均 | 802 | - | 1.663 | 0.826 | 0.100 | 5.998 | 330.5 |
标准偏差 | 21.370 | - | 0.046 | 0.021 | 0.002 | 0.076 | 9.836 |
变异系数 | 2.665 | - | 2.751 | 2.489 | 2.458 | 1.265 | 2.976 |
Claims (7)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR02/05819 | 2002-05-07 | ||
FR0205819A FR2839450B1 (fr) | 2002-05-07 | 2002-05-07 | Preparation medicamenteuse notamment pour le traitement des hernies discales |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1665546A true CN1665546A (zh) | 2005-09-07 |
CN100402020C CN100402020C (zh) | 2008-07-16 |
Family
ID=29286406
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB038129361A Expired - Fee Related CN100402020C (zh) | 2002-05-07 | 2003-05-07 | 特别用于椎间盘突出治疗的药物制剂 |
Country Status (15)
Country | Link |
---|---|
US (3) | US20070116647A1 (zh) |
EP (1) | EP1503803B1 (zh) |
CN (1) | CN100402020C (zh) |
AT (1) | ATE402719T1 (zh) |
AU (1) | AU2003262617A1 (zh) |
CA (1) | CA2498976C (zh) |
CY (1) | CY1108413T1 (zh) |
DE (1) | DE60322530D1 (zh) |
DK (1) | DK1503803T3 (zh) |
ES (1) | ES2309334T3 (zh) |
FR (1) | FR2839450B1 (zh) |
HK (1) | HK1081849A1 (zh) |
PT (1) | PT1503803E (zh) |
SI (1) | SI1503803T1 (zh) |
WO (1) | WO2003097108A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101296688B (zh) * | 2005-09-30 | 2011-12-07 | 雅克·泰龙 | 包含乙醇和不透x射线的脂溶性化合物的可注射粘稠医用制剂 |
WO2022184176A1 (zh) * | 2021-03-04 | 2022-09-09 | 苏州医本生命科技有限公司 | 一种含乙醇的药物组合物及其用途 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2839450B1 (fr) * | 2002-05-07 | 2006-04-07 | Aboville Marc D | Preparation medicamenteuse notamment pour le traitement des hernies discales |
EP4233880A3 (en) | 2017-09-08 | 2023-09-20 | MiNA Therapeutics Limited | Hnf4a sarna compositions and methods of use |
EP4219715A3 (en) | 2017-09-08 | 2023-09-06 | MiNA Therapeutics Limited | Stabilized cebpa sarna compositions and methods of use |
EP4017539A1 (en) | 2019-08-19 | 2022-06-29 | MiNA Therapeutics Limited | Oligonucleotide conjugate compositions and methods of use |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2162028A (en) * | 1938-06-25 | 1939-06-13 | Pittsburgh Plate Glass Co | Cellulose ether coating composition |
US2903396A (en) * | 1957-05-08 | 1959-09-08 | Ciba Pharm Prod Inc | Therapeutic compositions and method for treating parkinsonism |
EP0304403A3 (de) * | 1987-08-21 | 1990-12-12 | Ciba-Geigy Ag | Kunststoffzusammensetzung mit Supraleitern |
JPH02157029A (ja) * | 1988-12-09 | 1990-06-15 | Dainippon Pharmaceut Co Ltd | アニオン系界面活性剤含有組成物の安定化 |
US5830178A (en) * | 1996-10-11 | 1998-11-03 | Micro Therapeutics, Inc. | Methods for embolizing vascular sites with an emboilizing composition comprising dimethylsulfoxide |
US6476070B2 (en) * | 1997-09-11 | 2002-11-05 | Provasis Therapeutics Inc. | Compositions useful for remodeling body spaces |
US6015541A (en) * | 1997-11-03 | 2000-01-18 | Micro Therapeutics, Inc. | Radioactive embolizing compositions |
US6150022A (en) * | 1998-12-07 | 2000-11-21 | Flex Products, Inc. | Bright metal flake based pigments |
DE60041138D1 (de) * | 1999-05-21 | 2009-01-29 | Micro Therapeutics Inc | Hochvisköse embolisierende mittel |
JP2003500106A (ja) * | 1999-05-21 | 2003-01-07 | マイクロ・セラピューティクス・インコーポレーテッド | 一様分散させた高粘度塞栓性組成物を生体内で搬送するための方法 |
US6355058B1 (en) * | 1999-12-30 | 2002-03-12 | Advanced Cardiovascular Systems, Inc. | Stent with radiopaque coating consisting of particles in a binder |
US20020115904A1 (en) * | 2001-02-21 | 2002-08-22 | Brooke Ren | Magnetically controllable embolic materials |
FR2839450B1 (fr) * | 2002-05-07 | 2006-04-07 | Aboville Marc D | Preparation medicamenteuse notamment pour le traitement des hernies discales |
-
2002
- 2002-05-07 FR FR0205819A patent/FR2839450B1/fr not_active Expired - Lifetime
-
2003
- 2003-05-07 WO PCT/FR2003/001412 patent/WO2003097108A1/fr active IP Right Grant
- 2003-05-07 AT AT03752788T patent/ATE402719T1/de active
- 2003-05-07 ES ES03752788T patent/ES2309334T3/es not_active Expired - Lifetime
- 2003-05-07 EP EP03752788A patent/EP1503803B1/fr not_active Expired - Lifetime
- 2003-05-07 CN CNB038129361A patent/CN100402020C/zh not_active Expired - Fee Related
- 2003-05-07 AU AU2003262617A patent/AU2003262617A1/en not_active Abandoned
- 2003-05-07 DK DK03752788T patent/DK1503803T3/da active
- 2003-05-07 CA CA2498976A patent/CA2498976C/fr not_active Expired - Fee Related
- 2003-05-07 US US10/513,592 patent/US20070116647A1/en not_active Abandoned
- 2003-05-07 DE DE60322530T patent/DE60322530D1/de not_active Expired - Lifetime
- 2003-05-07 SI SI200331368T patent/SI1503803T1/sl unknown
- 2003-05-07 PT PT03752788T patent/PT1503803E/pt unknown
-
2006
- 2006-02-17 HK HK06102101.6A patent/HK1081849A1/xx not_active IP Right Cessation
-
2008
- 2008-10-14 CY CY20081101136T patent/CY1108413T1/el unknown
-
2010
- 2010-08-27 US US12/870,258 patent/US8153696B2/en not_active Expired - Fee Related
-
2012
- 2012-11-19 US US13/681,175 patent/US20130143970A1/en not_active Abandoned
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101296688B (zh) * | 2005-09-30 | 2011-12-07 | 雅克·泰龙 | 包含乙醇和不透x射线的脂溶性化合物的可注射粘稠医用制剂 |
WO2022184176A1 (zh) * | 2021-03-04 | 2022-09-09 | 苏州医本生命科技有限公司 | 一种含乙醇的药物组合物及其用途 |
Also Published As
Publication number | Publication date |
---|---|
US20070116647A1 (en) | 2007-05-24 |
US20130143970A1 (en) | 2013-06-06 |
WO2003097108A1 (fr) | 2003-11-27 |
DE60322530D1 (de) | 2008-09-11 |
CY1108413T1 (el) | 2014-02-12 |
SI1503803T1 (sl) | 2008-12-31 |
DK1503803T3 (da) | 2008-11-10 |
CA2498976C (fr) | 2011-09-06 |
CA2498976A1 (fr) | 2003-11-27 |
ES2309334T3 (es) | 2008-12-16 |
US8153696B2 (en) | 2012-04-10 |
FR2839450A1 (fr) | 2003-11-14 |
CN100402020C (zh) | 2008-07-16 |
HK1081849A1 (en) | 2006-05-26 |
US20100329991A1 (en) | 2010-12-30 |
ATE402719T1 (de) | 2008-08-15 |
AU2003262617A1 (en) | 2003-12-02 |
PT1503803E (pt) | 2008-10-16 |
EP1503803A1 (fr) | 2005-02-09 |
EP1503803B1 (fr) | 2008-07-30 |
FR2839450B1 (fr) | 2006-04-07 |
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Legal Events
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PB01 | Publication | ||
ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: RONALD KEITH MILLER; ARCHIBALD IAN JERRY RICE THE BREHON; CHRISTIAN LABOR DUE TO GRID; CHRISTIAN SHAPIYI Effective date: 20050805 |
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Effective date of registration: 20050805 Address after: France Fleury sur Orne Applicant after: Theron Jacques Address before: France Fleury sur Orne Applicant before: Theron Jacques Co-applicant before: Christina Daboville Co-applicant before: Solinas Daboville Co-applicant before: Kome Daboville Co-applicant before: Quentin Daboville |
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