CN1663556A - Externally applied drug/cosmetic for inhibiting alopeia or/and promoting hair regeneration - Google Patents
Externally applied drug/cosmetic for inhibiting alopeia or/and promoting hair regeneration Download PDFInfo
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- CN1663556A CN1663556A CN 200410021957 CN200410021957A CN1663556A CN 1663556 A CN1663556 A CN 1663556A CN 200410021957 CN200410021957 CN 200410021957 CN 200410021957 A CN200410021957 A CN 200410021957A CN 1663556 A CN1663556 A CN 1663556A
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Abstract
The invention discloses an externally applied drug or/and cosmetic for inhibiting alopeia or/and promoting hair regeneration, wherein the drug or/and cosmetic contains one or more phenolic acid or/and its derivatives, the content of the phenolic acid or/and phenolic acid derivatives is 0.05-15%, by daubing the externally use drug or/and cosmetic onto hair roots and epicranium, baldness can be suppressed appreciably, and hair growing can be promoted.
Description
Technical field
The present invention relates to phenolic acid and derivant thereof as the inhibition alopecia of effective component or/and promote the external used medicine of hair restoration or/and cosmetics belong to external used medicine and cosmetic field.
Background technology
In dog-eat-dog, life style modern society jumpy, hair loss patient increases gradually, and data shows that nearly in the world 50% adult man is subjected to the puzzlement of alopecia at present.And hair loss patient is just presenting the trend of rejuvenation.The tracking investigation that a male surplus ten thousand is carried out shows have 60% male the alopecia phenomenon just to occur before 25 years old, and the ratio that occurred alopecia at 30 years old in the past is unexpectedly up to 83.9%.Alopecia not only influences attractive in appearance, the patient is produced feel oneself inferior, depressed, interior to etc. the bad mental influence, can impact its social communication, employment, promotion, bring misery to the patient, treatment and prevention baldness seem more and more important.
By different classification method, alopecia has different types, tens kinds of the classification as many as that has, the alopecia that causes as alopecia areata, seborrheic alopecia, alopecia totalis, pathologic alopecia, nervous alopecia, dystrophic alopecia, medicine and disease etc.But common is mainly two types, i.e. alopecia areata, seborrheic alopecia.Seborrheic alopecia accounts for more than 95% of hair loss patient sum.Seborrheic alopecia mainly betides young male, but the female patient number had the trend of increase in the last few years, so becomes the emphasis of concern.
Though more existing hair growth promotings, hair care category medicine and cosmetics, product variety is less, and some product effects are limited, needs development more effective hair growth promoting, hair care and hair care product.
Phenolic acid compound is gallic acid and benzoaric acid and derivant thereof, exists extensivelyr in plant, and the ellagic acid in certain kind of berries class such as fruit, berry such as Fructus Fragariae Ananssae, raspberry and the Punica granatum L. is that the world of medicine widely praises highly.The phenolic acid compound shape that can dissociate in plant exists, and more is to exist in conjunction with shape.Generally be to form the bonded chemical compound of form with glycoside (glycosides) or ester bond, acid, alkali or enzyme facile hydrolysis are met in its combining form, generate the product of small-molecular weight simultaneously, and therefore many these class phenolic acid are also referred to as hydrolyzable tannic acid or hydrolyzable tannin.This compounds has unique hydroxyl structure, determines it that stronger chemistry and physiologically active are arranged.Its key property is the structure function that protein, polysaccharide, alkaloid are produced, with the complexing of metallic.
Various countries mainly contain the effect report of phenolic acid and derivant thereof: anticancer, mutation; Suppress HIV (human immunodeficiency virus) (Human Immunodeficiency Virus); Antioxidation; Inhibitory action to various bacteria, virus; Blood clotting; Liver protection function.
Some phenolic acid compounds and derivant thereof are used existing historical for many years as oral drugs, as the use of ellagic acid as anti-AIDS and treatment hepatitis medicament; Chlorogenic acid is as the use of antiviral drugs; And caffeic acid is as the use of medicine, its safety of these operation instructions.
Aspect cosmetics, have patent application disclose as the ellagic acid of a kind of important derivatives of phenolic acid as whiten, depigmentation, anti-ultraviolet, prevent the application of free radical, anti-skin carcinoma, antiphlogistic cosmetic industry composition.But do not see ellagic acid as the cosmetics of hair care, hair strengthening and hair growth promoting effective component and the report of external used medicine, simultaneously, do not see the report that phenolic acid and derivant thereof are used in cosmetics and external used medicine as the effective component of hair care, hair strengthening and hair growth promoting yet.
Summary of the invention
The purpose of this invention is to provide and a kind ofly suppress alopecia or/and promote the external used medicine of hair restoration or/and cosmetics is characterized in that described medicine or/and contain one or more phenolic acid in the cosmetics or/and the phenolic acid derivant.
Medicine of the present invention is or/and cosmetics, and described inhibition alopecia comprises anti-loss generation, also comprises stoping alopecia to continue development, can be expressed as hair strengthening with popular language.More wide in range implication can be hair care, hair care.
Medicine of the present invention is or/and cosmetics, and described promotion hair restoration can popularly be expressed as hair growth promoting, educate and send out.
That is to say that inhibition alopecia of the present invention is or/and promote the external used medicine of hair restoration or/and cosmetics can be explained or be interpreted as (1) treatment or/and the external used medicine or the cosmetics of prevention baldness; (2) external used medicine or the cosmetics of promotion hair restoration.
Medicine of the present invention is or/and cosmetics, and described cosmetics comprise the cosmetics of definition of industry, as frost, cream etc., also comprise hair lotion, as shampoo.
Medicine or cosmetics generally are made up of effective component and auxiliary composition, and medicine of the present invention is or/and better selection of cosmetics is with the effective component phenolic acid or/and the compositions of phenolic acid derivant and liquid medium combination.Therefore external used medicine of the present invention is or/and cosmetics, it is characterized in that described external used medicine or/and cosmetics by one or more phenolic acid or/and the external used medicine that phenolic acid derivant, liquid medium are formed or/and cosmetic composition.
By phenolic acid or/and the implication of the compositions that phenolic acid derivant, liquid medium are formed be: external used medicine or cosmetic composition can be made up of phenolic acid, liquid medium; Also can form by phenolic acid derivant, liquid medium; Can also form by phenolic acid, phenolic acid derivant, liquid medium.
Described liquid medium can be any external used medicine or cosmetics acceptable liquid, and preferred water is or/and alcohol.Described water is deionized water preferably, can select distilled water or cold water.Described alcohol is ethanol, ethylene glycol, Polyethylene Glycol, propylene glycol, glycerol, hexanediol, dipropylene glycol preferably, can select to use one or more.
Be medicine of the present invention or/and cosmetic composition, it is characterized in that by one or more phenolic acid or/and phenolic acid derivant, water or/and alcohol form.
Medicine of the present invention is or/and cosmetics, except that selecting liquid medium to constitute the compositions, can also use other excipient or/and carrier constitutes compositions, as using gelling, colloidal sol, pectin, natural gum, methylcellulose and salt, thickening agent etc., to be prepared into the on-liquid dosage form.
Be external used medicine of the present invention or/and cosmetics, it is characterized in that described external used medicine or/and cosmetics by one or more phenolic acid or/and phenolic acid derivant, excipient or/and the external used medicine that carrier is formed or/and cosmetic composition.
Excipient is or/and carrier can also can use more than one with a kind of.
Medicine of the present invention is or/and cosmetics, or medicine is or/and cosmetic composition, and described phenolic acid also can be synthetic or/and the phenolic acid derivant can be natural.Preferred natural phenolic acid and derivant thereof.
Medicine of the present invention is or/and cosmetics, the glycosides (glycoside) that described phenolic acid derivant is a phenolic acid, the salt of phenolic acid, the metal complex of phenolic acid, the ether of phenolic acid, the ester of phenolic acid, and the catabolite of the polymerization of phenolic acid and phenolic acid.
Its salt is alkali metal salt preferably, as sodium salt and potassium salt, as the sodium salt and the potassium salt of ellagic acid.
Medicine of the present invention is or/and cosmetics, as suppressing alopecia or/and promote the external used medicine of hair restoration or/and the phenolic acid of the effective component of cosmetics and derivant thereof can be the derivants of the phenolic acid or the phenolic acid of any kind of.
As preferred compound of phenolic acid, preferred especially ellagic acid and derivant thereof.
As preferred compound of phenolic acid, preferred hydrolyzable tannic acid (hydrolyzable tannin) and derivant thereof.
As preferred compound of phenolic acid, also preferred coumaric acid, chlorogenic acid, caffeic acid, and derivant.
Medicine of the present invention is or/and cosmetics, the preparation of phenolic acid and derivant thereof belongs to already known processes and mature technology, and many extracts or sintetics and commodity are arranged, as commodity such as ellagic acid, chlorogenic acid, caffeic acids, these products and commodity can be as the phenolic acid and the derivants thereof of the present invention's use.
Medicine of the present invention is or/and cosmetics, the preparation of external used medicine and cosmetics belongs to already known processes and mature technology, and many medicines and cosmetic base commodity selling arranged, as commodity such as cream substrate, vanishing cream substrate, these preparation technologies, and medicine and cosmetic base commodity can use as compositions of the present invention.
Medicine of the present invention is or/and cosmetics, described phenolic acid or/and the phenolic acid derivant at medicine or/and the percentage by weight in the cosmetics is 0.01%-80%, preferred 0.05%-15%.
Medicine of the present invention is or/and cosmetics, described phenolic acid or/and the phenolic acid derivant at medicine or/and the percentage by weight in the compositions of cosmetics is 0.01%-80%, preferred 0.05%-15%.
At medicine of the present invention or/and in the cosmetics, and at medicine of the present invention or/and also comprise in the compositions of cosmetics and can add other drug composition or active ingredient as required, with the use of uniting as active ingredient, for example, can add vitamin E, aminoacid, blood circulation promoter, cell activation factor, antiinflammatory etc.Described these other drug compositions or active ingredient can be used, and also can not use, and whether it uses the needs that depend on preparation.
At medicine of the present invention or/and in the cosmetics, and at medicine of the present invention or/and in the compositions of cosmetics, also comprise adding being selected from the conventional external used medicine or the auxiliary agent of cosmetics, as gellant, thickening agent, surfactant, antiseptic, antioxidant, emulsifying agent, wetting agent, pigment, lubricant, wetting agent, binding agent, antiseptic, antibacterial, dandruff removing agent, essence etc.Described these auxiliary agents can use, and also can not use, and can use a kind ofly, also can use multiplely, and how much whether it uses and use depends on the needs that prepare dosage form.
Medicine of the present invention be or/and cosmetics can be made any dosage form that is applicable to use, as liquid, ointment, Emulsion, emulsion, serosity, frost, cream, gel, colloidal sol, mousse, aerosol or spray, and solid form.
What especially be suitable for is liquid preparation, and as water preparation, pure agent, or the agent of water alcohol are such as the water preparation of using as hair-washing hair-care, as the water alcohol agent of hair care usefulness etc.
Inhibition alopecia of the present invention is or/and promote the external used medicine or the cosmetics of hair restoration, and its preparation technology is the common process of external used medicine or cosmetics, and its preparation illustrates in the specific embodiment.
The specific embodiment
The invention provides but be not limited to following examples
Embodiment 1
Ellagic acid 3%, propylene glycol 5.0%, glycerol 5%, ethanol 8.0%, natural gum (arabic gum) 0.3%, surplus is a distilled water, 100 kilograms of gross weights.
Propylene glycol, glycerol, alcoholic acid mixing are dissolved in ellagic acid wherein;
The distilled water heating with the arabic gum swelling, stirs;
With two kinds of solution mixing and stirring, be packaged into bottle, make hair conditioner.
Embodiment 2
Ellagic acid 5%, ethanol 10%, Polyethylene Glycol 15%, glycerol 2.5%, surplus is a distilled water, essence is an amount of, 50 kilograms of gross weights.
Ellagic acid is dissolved in ethanol, adds distilled water again, add other each components then, mix homogeneously is packaged into bottle, makes hair conditioner.
Embodiment 3
Ellagic acid 5%, water 95%, 100 kilograms of gross weights.
Ellagic acid is water-soluble, stir after the dissolving fully, be packaged into bottle, make shampoo.
Embodiment 4
Ellagic acid 3%, chlorogenic acid 2%, stearic acid 4.5%, Cera Flava 2.0%, isopropyl myristate 2.6%, spermol 2.8%, essence 0.2%, antiseptic is an amount of, and surplus is a distilled water.
Earlier ellagic acid, chlorogenic acid are added in the entry, again other raw materials except that essence are added in the entry after the dissolving fully, be heated to 80 degrees centigrade, stir evenly and make its emulsifying.Add essence when being cooled to 45 degrees centigrade, stir, cooling back packing is promptly made the hair strengthening hair-growing cream.
Embodiment 5
Octadecanol 5.0%, white oil 40%, white vaseline 5.0%, glyceryl monostearate 4.0%, sodium lauryl sulfate 0.5%, ellagic acid 3%, caffeic acid 2%, essence, antiseptic are an amount of, and surplus is a water.
Preceding 5 kinds of components and water are heated to 80 degrees centigrade respectively, and ellagic acid, caffeic acid add in the entry, all mix then and stir, and add essence, antiseptic when evenly postcooling is spent to Celsius 40, stir evenly, and packing is made hair strengthening hair growth promoting frost.
Embodiment 6
Ellagic acid 3%, caffeic acid 2%, drug ointment substrate 95%, 30 kilograms of gross weights.With the slightly heating of drug ointment substrate, ellagic acid and caffeic acid mix homogeneously, packing, the drug ointment agent.
Embodiment 7
With the hair conditioner 40% (weight) that embodiment 2 makes, propellant 60% is prepared into the bottle spray in the usual way.
Embodiment 8
Chlorogenic acid 3%, caffeic acid 2%, propylene glycol 5.0%, glycerol 5%, ethanol 8.0%, natural gum (arabic gum) 0.3%, surplus is a distilled water, 100 kilograms of gross weights.
Propylene glycol, glycerol, alcoholic acid mixing are dissolved in chlorogenic acid, caffeic acid wherein;
The distilled water heating with the arabic gum swelling, stirs;
With two kinds of solution mixing and stirring, be packaged into bottle, make hair conditioner.
The invention effect
For the present invention is described better, now is used in combination effect and sets forth.
One, physical data
Seborrheic alopecia 48 examples, alopecia areata 25 examples, alopecia totalis 5 examples, other alopecia 9 examples, totally 87 examples.Age: in 19-51 year, account for 89% below 45 years old.Course of disease August-7 year, male 72 examples, women 6 examples.
Two, Therapeutic Method
Use the hair strengthening hair growth liquor of pressing embodiment 2 preparations, smear root of hair and reach scalp on every side, every day 2-3 time, taking orally and external used medicine without other hair care and hair growths between the operating period.4 weeks were a course of treatment.
Three, efficacy determination
Use the judgement that promptly performed an analysis in 4 weeks continuously
Produce effects: old state obviously improves, and the excessive secretion of sebum is effectively suppressed, and alopecia district area dwindles more than 2/3rds, or the germinating of more New Development is arranged, and draw to rub hair and do not have improper alopecia, or improper alopecia obviously reduces.
Effectively: old state has certain improvement, and the excessive secretion of sebum obtains part and suppresses, and alopecia district area has and dwindles, and there is the New Development germinating subregion or does not have the New Development germinating, and improper alopecia alleviates to some extent, but still can not suppress improper alopecia fully.
Invalid: old state do not have improvement, can not suppress the sebum excessive secretion, can not alleviate or suppress improper alopecia, no hair regeneration.
Three, result
| Produce effects | Effectively | Invalid | Effectively total | |||||
| Example | ??％ | Example | ??％ | Example | ??％ | Example | ??％ | |
| Seborrheic alopecia | ????36 | ??75.0 | ????12 | ??25.0 | ????48 | ??100.0 | ||
| Alopecia areata | ????8 | ??32.0 | ????16 | ??64.0 | ????1 | ??4.0 | ????24 | ??96.0 |
| Alopecia totalis | ????4 | ??80.0 | ????1 | ??20.0 | ????4 | ??80.0 | ||
| Other alopecias | ????6 | ??66.7 | ????3 | ??33.3 | ????9 | ??100.0 | ||
Most of patients is used and is shown, uses and can obviously feel that scalp became dry in 1-3 days, and alopecia alleviates gradually.Can obviously suppress improper alopecia in one week.
Claims (10)
1, suppresses alopecia or/and promote the external used medicine of hair restoration or/and cosmetics is characterized in that described medicine or/and contain one or more phenolic acid in the cosmetics or/and the phenolic acid derivant.
2, according to the external used medicine of claim 1 or/and cosmetics, it is characterized in that described external used medicine or/and cosmetics by one or more phenolic acid or/and the external used medicine that phenolic acid derivant, liquid medium are formed or/and cosmetic composition.Described liquid medium preferred water is or/and alcohol.
3, according to the external used medicine of claim 1 or/and cosmetics, it is characterized in that described external used medicine or/and cosmetics by one or more phenolic acid or/and phenolic acid derivant, excipient or/and the external used medicine that carrier is formed or/and cosmetic composition.
4, according to the arbitrary described medicine of claim 1-3 or/and cosmetics, it is characterized in that described phenolic acid or/and the phenolic acid derivant is natural or synthetic.Preferred natural phenolic acid and derivant thereof.
5, according to the arbitrary described medicine of claim 1-4 or/and cosmetics is characterized in that described phenolic acid derivant is the glycosides of phenolic acid compound of phenolic acid, salt, metal complex, ether, ester, and the polymerization of compound of phenolic acid and catabolite.
6, according to the arbitrary described medicine of claim 1-4 or/and cosmetics is characterized in that described phenolic acid or/and preferred ellagic acid of phenolic acid derivant and derivant thereof.
7, according to the arbitrary described medicine of claim 1-4 or/and cosmetics is characterized in that described phenolic acid or/and preferred hydrolyzable tannic acid of phenolic acid derivant and derivant thereof.
8, according to the arbitrary described medicine of claim 1-4 or/and cosmetics, it is characterized in that described phenolic acid or/and the preferred coumaric acid of phenolic acid derivant, chlorogenic acid, caffeic acid, and derivant.
9, according to the arbitrary described medicine of claim 1-8 or/and cosmetics, it is characterized in that described phenolic acid or/and the phenolic acid derivant at medicine or/and in the cosmetics, or at medicine or/and the percentage by weight in the cosmetic composition is 0.01%-80%, preferred 0.05%-15%.
10, according to the arbitrary described medicine of claim 1-8 or/and cosmetics, it is characterized in that at described medicine or/and in the cosmetics, or at medicine or/and in the cosmetic composition, also comprise and to add other drug composition or active ingredient as required, also comprise adding and be selected from the conventional external used medicine or the auxiliary agent of cosmetics, as gellant, thickening agent, surfactant, antiseptic, antioxidant, emulsifying agent, wetting agent, pigment, lubricant, wetting agent, binding agent, antiseptic, antibacterial, dandruff removing agent, essence etc., make any dosage form that is applicable to use, as liquid, ointment, Emulsion, emulsion, serosity, frost, cream, gel, colloidal sol, mousse, aerosol or spray, and solid form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410021957 CN1663556A (en) | 2004-03-03 | 2004-03-03 | Externally applied drug/cosmetic for inhibiting alopeia or/and promoting hair regeneration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410021957 CN1663556A (en) | 2004-03-03 | 2004-03-03 | Externally applied drug/cosmetic for inhibiting alopeia or/and promoting hair regeneration |
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| CN1663556A true CN1663556A (en) | 2005-09-07 |
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|---|---|---|---|
| CN 200410021957 Pending CN1663556A (en) | 2004-03-03 | 2004-03-03 | Externally applied drug/cosmetic for inhibiting alopeia or/and promoting hair regeneration |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107496233A (en) * | 2017-08-30 | 2017-12-22 | 广州聚注通用技术研究院有限公司 | A kind of Anti-hair loss additive and its application |
| CN108014328A (en) * | 2017-12-19 | 2018-05-11 | 吴广印 | A kind of pre-Anti-hair loss, the formula for promoting hair tonic material and preparation method thereof |
-
2004
- 2004-03-03 CN CN 200410021957 patent/CN1663556A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107496233A (en) * | 2017-08-30 | 2017-12-22 | 广州聚注通用技术研究院有限公司 | A kind of Anti-hair loss additive and its application |
| CN108014328A (en) * | 2017-12-19 | 2018-05-11 | 吴广印 | A kind of pre-Anti-hair loss, the formula for promoting hair tonic material and preparation method thereof |
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