CN1660227A - Capsule of dual gen-sengs and preparing technique - Google Patents

Abstract

A Chinese medicine 'Shuangshen capsule' for treating diabetes is prepared from 10 Chinese-medicinal materials including ginseng, scrophularia root, trichosanthes root, etc through decocting, concentrating, pulverizing, granulating and loading in capsules.

Description

SHUANGSHEN JIAONANG and preparation technology thereof

Affiliated technical field

SHUANGSHEN JIAONANG of the present invention and preparation technology thereof belong to the treatment Glucovance, relate in particular to Chinese medicine preparation and preparation technology thereof with Chinese prescription treatment Qi and Yin deficiency diabetes mellitus.

Background technology

The diabetes that modern medicine is alleged are equivalent to the diabetes of the traditional Chinese medical science.And significance symptom multiple with it of quenching one's thirst becomes one of traditional Chinese medical science understanding disease the earliest.The aspects such as the cause of disease, pathogenesis, clinical manifestation, the rule of treatment and prognosis that just have 14 chapters to relate in " interior warp " to quench one's thirst.Thereafter the Chunyu Yi of the Western Han Dynastry, the Eastern Han Dynasty to the Chao Yuanfang (550-630 A.D.) of Zhong Jing, Sui Dynasty, the Sun Simiao of the Tang Dynasty, and even famous doctor such as Liu's interchannel in gold dollar period, Zhang Zihe, Zhu Danxi family, though development is respectively arranged, to the pathogenesis understanding of quenching one's thirst, always nothing more than " deficiency of YIN is scorching ".Ming Dynasty physician wears first gift starting weight " deficiency of vital energy ", and clinical emphasis QI invigorating is placed on the first place for the treatment of diabetes to QI invigorating, and with the Radix Astragali 61 soup (Radix Astragali, Radix Glycyrrhizae) treatments " three types of diabetes ", the institute of mending forefathers is not enough, has improved the treatment of diabetes level greatly.Modern Chinese medicine is thought congenital defect or lack of proper care after one's birth, and overworks, and sexual life is forfeited one's integrity, and seven emotions are too drastic, main fine strain of millet savoury, injury due to diet, or being invaded by exogenous pathogen, and the heat-transformation impairment of YIN makes cloudy body fluid deficiency consumption, scorching inclined to one side Sheng, passages through which vital energy circulates internal organs of a specified duration lose to support to form and quench one's thirst.Pathogenesis to diabetes has six type persons such as the lung of being divided into dryness of the stomach heat, dryness of the intestine Tianjin wound, the hepatic and renal YIN deficiency, negative and positive two are lost, deficiency of spleen-QI and stomach-QI, damp and hot middle resistance, classify at six types, traditional tcm prescription medicine is numerous, Chinese patent medicine seldom but suit the medicine to the illness in market, chemical agent is numerous, but the chemical agent side effect is bigger, and it is very uncomfortable to take the patient for a long time.Diabetes are divided into the deficiency of YIN is scorching, deficiency of both QI and YIN amphitypy person and have in recent years.Though before a kind of six type point-scores absolutely clear in theory, on clinical practice, be difficult to see so simple pattern of syndrome, the deficiency of YIN is scorching, the deficiency of both QI and YIN amphitypy meets clinical practice and diabetes are divided into.Particularly type of deficiency of both QI and YIN is clinical more common, and it is more of a specified duration to show as the course of disease, tired mind, and limbs fatigue, xerostomia happiness drink, or polyphagia polyuria, or voice are humble, and soreness of the waist and knees is breathed hard etc.Wherein, tired mind, limbs fatigue, voice are humble, breathe hard to be the card of the deficiency of vital energy; Xerostomia happiness drink, polyphagia polyuria, soreness of the waist and knees are the card of the deficiency of YIN; Insufficiency of the spleen showers such as inappetence are also arranged.Chinese patent medicine exploitation at the treatment Qi and Yin deficiency diabetes mellitus at present still is in developmental stage.

Summary of the invention

The objective of the invention is: provide scientific formulation, medication oligospermia, monarch compatibility proper for the Qi and Yin deficiency diabetes mellitus patient, complementary action is strong, pure Chinese medicinal preparation evident in efficacy, reach boosting qi and nourishing yin, moisturize spleen invigorating, pathogenic fire purging is promoted the production of body fluid, improve the disorder of patient's body lipid effectively, alleviate diabetic symptom.

To achieve these goals, the technical solution used in the present invention is: SHUANGSHEN JIAONANG is according to the main etiology and pathogenesis of Qi and Yin deficiency diabetes mellitus, with boosting qi and nourishing yin, moisturize spleen invigorating, pathogenic fire purging is promoted the production of body fluid and is principle of treatment, the crude drug total amount is 820 grams in the prescription, is made up of Radix Ginseng 50 grams, Radix Scrophulariae 60 grams, Radix Trichosanthis 60 grams, Rhizoma Dioscoreae 100 grams, the Radix Astragali 100 grams, Radix Rehmanniae Preparata 100 grams, Radix Rehmanniae 100 grams, Rhizoma Coptidis 50 grams, Radix Puerariae 100 grams, Radix Achyranthis Bidentatae 100 grams.SHUANGSHEN JIAONANG preparation technology is three parts altogether: at first get Radix Ginseng, Radix Scrophulariae, Radix Trichosanthis, Rhizoma Coptidis and dry below 80 ℃ and pulverized 80 mesh sieves and become the fine powder medicine standby; Get Rhizoma Dioscoreae, the Radix Astragali, Radix Rehmanniae Preparata, Radix Rehmanniae, Radix Puerariae, Radix Achyranthis Bidentatae again and add 8 times of water gagings and decocted 2 hours, filter to such an extent that decocting liquid is standby, medicinal residues are added 6 times of water gagings again decocted 1 hour, collecting decoction also is evaporated to the clear paste of relative density 1.22-1.25 (60 ℃ of heat are surveyed); Mix into clear paste thoroughly soft material with standby thin medicated powder at last, cross 14 mesh sieves and granulate, oven dry is respectively charged into No. 0 capsule and gets patent medicine below 80 ℃.Chinese medicine thinks that diabetes are diabetes, The present invention be directed to deficiency of both QI and YIN paradiabetes boosting qi and nourishing yin, moisturize spleen invigorating, pathogenic fire purging is promoted the production of body fluid, in SHUANGSHEN JIAONANG, Radix Ginseng has strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the intelligence development functions of calming the nerves, and cures mainly that the deficiency of vital energy is desired to take off, insufficiency of the spleen fatigue and weakness, the empty hyperhidrosis of body, deficiency of vital energy Tianjin wound are thirsty, quench one's thirst; Radix Scrophulariae has the function of clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, cures mainly warm febrile disease and joins the army that blood, fever of the body, excessive thirst, crimson tongue, hectic fever due to YIN-deficiency battalion cough, fidgets due to deficiency is insomnia; The Radix Astragali has the function of benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening, curing mainly internal injury overstrain, spleen considers and lets out tired, spontaneous perspiration, night sweat, the function that Radix Rehmanniae has clearing away heat and cooling blood, promotes the production of body fluid and moisturize cures mainly anxious heat in blood disease, unconsciousness due to high fever, Tianjin and hinders excessive thirst, consumptive fever cough; Radix Rehmanniae Preparata has the YIN nourishing of enriching blood, beneficial essence is filled out the marrow function, cures mainly that blood deficiency and yellow complexion, dizzy cardiopalmus, liver bone are cloudy to be lost, and hectic fever night sweat, quenches one's thirst; The function that Rhizoma Dioscoreae has spleen reinforcing, supports lung, reinforces the kidney, benefit is smart cures mainly diarrhea due to hypofunction of the spleen, lack of appetite edema, cough due to deficiency of the lung, the frequent micturition of quenching one's thirst, suffer from a deficiency of the kidney; Rhizoma Coptidis has heat clearing away and separates fire, dampness antidotal function, cures mainly diarrhea due to hypofunction of the spleen; Radix Trichosanthis has clearing away heat and promoting production of body fluid, moistening the lung and resolving phlegm, detumescence and apocenosis effect, cures mainly that calentura is thirsty, the polydipsia of quenching one's thirst, lung-heat type cough; Radix Puerariae has expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal efficacy, cures mainly that turbid disease is thirsty, diabetes, hypertension, coronary heart disease; Radix Achyranthis Bidentatae has invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, conducting blood to flow downwards, inducing diuresis for treating stranguria syndrome effect, cures mainly pyretic stranguria stranguria with blood, flaccidity and weakness of the lower limbs.In prescription, with giving young employees remedial-courses in general knowledge and vocational skills gas the moon is principle of treatment, so with ginseng qi-tonifying, Radix Scrophulariae nourishing YIN be monarch drug altogether, the Radix Astragali ginseng QI invigorating of helping others, it is ministerial drug altogether that Radix Rehmanniae helps the Radix Scrophulariae nourishing YIN, Radix Rehmanniae Preparata is moisturized, Rhizoma Dioscoreae spleen invigorating, Rhizoma Coptidis pathogenic fire purging, Radix Trichosanthis, Radix Puerariae promote the production of body fluid altogether and to be adjuvant drug, and reuse Radix Achyranthis Bidentatae priming is gone into Liver and kidney and boosting qi and nourishing yin is played in the source of YIN nourishing altogether, moisturize spleen invigorating, pathogenic fire purging is promoted the production of body fluid, and effectively treats Qi and Yin deficiency diabetes mellitus.Modern Chinese medicine research confirms, the Radix Ginseng heavy dose all presents the obvious functions of blood sugar effect to normal dogs and alloxan diabetes dog, and can strengthen the decomposition of epinephrine to hepatic glycogen, Radix Ginseng total saponins can stimulate isolating rat Langerhans islet to discharge, the Radix Scrophulariae fluid extract is in and is exempted from subcutaneous injection, can cause that blood glucose slightly reduces; The Radix Astragali has dual regulation to blood glucose; The replenishing YIN and removing heat of Radix Rehmanniae juice is quenched the thirst, can control gastric qi contain real, accumulate the long-pending symptoms of quenching one's thirst such as heat, xerostomia is fidgety that are; Radix Rehmanniae Preparata can not only improve symptom, and the thyroxine state of energy dysregulation, and has the mitotic effect of the epithelial cell of inhibition; The Rhizoma Dioscoreae water decoction is given continuous 10 days of mouse stomach, can reduce the blood glucose of normal mouse, and the mice diabetes that alloxan is caused have prevention and therapeutical effect; Rhizoma Coptidis water decoction or berberine all can reduce normal mouse blood glucose for mouse stomach, and are a certain amount of effect relationship; THFPS gives the normal mouse subcutaneous injection after 7 hours, and blood glucose obviously descends, and gives the hyperglycemia mouse subcutaneous injection after 7 hours, and significant dose dependent is arranged, and hyperglycemia is had obvious hypoglycemic activity; Contained ecdysterone of Radix Achyranthis Bidentatae and inokosterone have obvious hypoglycemic activity to rat hyperglycemia due to the glucagon when irritating stomach.Many each effective ingredient complementations of medicine can effectively reduce diabetics blood glucose, and the continuation that suppresses blood glucose raises.Radix Triplostegiae Grandiflorae intestinal capsule preparation technology adds many medicine clear paste through the fine powder medicine directly to mix soft material granulation dress capsule, and preparation technology is easy, low production cost.

SHUANGSHEN JIAONANG cures mainly relevant Pharmacodynamic test of active extract with function and confirms in preclinical study: SHUANGSHEN JIAONANG has remarkable hypoglycemic activity to diabetic mice, and medication has tangible dose-effect relationship, and recommending clinical day dosage is the 2.4-4.8 gram; Oral; 6 weeks of medication are a course of treatment.

The invention has the beneficial effects as follows: scientific formulation, the monarch compatibility is reasonable, and preparation technology is easy, low production cost, have complementary functions by many medicines, the effect of can bring into play boosting qi and nourishing yin, moisturize spleen invigorating, pathogenic fire purging being promoted the production of body fluid improves the deficiency of both QI and YIN diabetic symptom effectively.

The specific embodiment

1, the SHUANGSHEN JIAONANG prescription is made up of 10 flavor Chinese crude drugs, wherein Radix Ginseng 50 grams, Radix Scrophulariae 60 grams, Radix Trichosanthis 60 grams, Rhizoma Dioscoreae 100 grams, the Radix Astragali 100 grams, Radix Rehmanniae Preparata 100 grams, Radix Rehmanniae 100 grams, Rhizoma Coptidis 50 grams, Radix Puerariae 100 grams, Radix Achyranthis Bidentatae 100 grams; Weighing is standby after getting crude drug remove impurity well sifted respectively by existing tcm and herbal slice standard before the preparation.

2, SHUANGSHEN JIAONANG preparation technology

(1) getting Radix Ginseng, Radix Scrophulariae, Radix Trichosanthis, Rhizoma Coptidis dries below 80 ℃ and pulverized 80 mesh sieves to get the fine powder medicine standby.

(2) getting the Radix Astragali, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Radix Rehmanniae, Radix Puerariae, Radix Achyranthis Bidentatae decocted 2 hours with 8 times of water gagings, get decocting liquid after the filtration, medicinal residues add 6 times of water gagings again and decocted 1 hour, filter the back and merge twice decocting liquid and be evaporated to relative density 1.22-1.25 (60 ℃ of heat are surveyed) clear paste.

(3) mix into clear paste thoroughly soft material with standby fine powder medicine, cross 14 order nylon mesh and granulate, oven dry below 80 ℃ divides 1000 No. 0 capsules of packing into to get patent medicine.

Claims (2)

1, a kind of SHUANGSHEN JIAONANG, it is characterized in that the crude drug total amount is 820 grams, form by Radix Ginseng 50 grams, Radix Scrophulariae 60 grams, Radix Trichosanthis 60 grams, Rhizoma Dioscoreae 100 grams, the Radix Astragali 100 grams, Radix Rehmanniae Preparata 100 grams, Radix Rehmanniae 100 grams, Rhizoma Coptidis 50 grams, Radix Puerariae 100 grams, Radix Achyranthis Bidentatae 100 grams.

2, the preparation technology of SHUANGSHEN JIAONANG according to claim 1, it is characterized in that at first getting Radix Ginseng, Radix Scrophulariae, Radix Trichosanthis, Rhizoma Coptidis is dried below 80 ℃ and pulverized 80 mesh sieves and become the fine powder medicine standby, get Rhizoma Dioscoreae again, the Radix Astragali, Radix Rehmanniae Preparata, Radix Rehmanniae, Radix Puerariae, Radix Achyranthis Bidentatae adds 8 times of water gagings and decocted 2 hours, filter to such an extent that decocting liquid is standby, medicinal residues are added 6 times of water gagings again to be decocted 1 hour, collecting decoction also is evaporated to relative density 1.22-1.25 (60 ℃ of heat are surveyed) clear paste, mix into clear paste thoroughly soft material with standby fine powder medicine, crossing 14 mesh sieves granulates, oven dry is respectively charged into No. 0 capsule and gets patent medicine below 80 ℃.