CN1658892A - 参与蛋白质-蛋白质相互作用的蛋白质亚群的分离方法 - Google Patents

参与蛋白质-蛋白质相互作用的蛋白质亚群的分离方法 Download PDF

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Publication number
CN1658892A
CN1658892A CN02829465.3A CN02829465A CN1658892A CN 1658892 A CN1658892 A CN 1658892A CN 02829465 A CN02829465 A CN 02829465A CN 1658892 A CN1658892 A CN 1658892A
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China
Prior art keywords
protein
holder
proteins
interaction
mixture
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Pending
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CN02829465.3A
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English (en)
Chinese (zh)
Inventor
D·L·阿尔康
T·J·尼尔森
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Blanchette Rockefeller Neuroscience Institute
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Blanchette Rockefeller Neuroscience Institute
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Publication of CN1658892A publication Critical patent/CN1658892A/zh
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN02829465.3A 2002-08-14 2002-08-14 参与蛋白质-蛋白质相互作用的蛋白质亚群的分离方法 Pending CN1658892A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/025845 WO2004019967A1 (en) 2002-08-14 2002-08-14 Method for isolating subpopulations of proteins that engage in protein-protein interactions

Publications (1)

Publication Number Publication Date
CN1658892A true CN1658892A (zh) 2005-08-24

Family

ID=31975561

Family Applications (1)

Application Number Title Priority Date Filing Date
CN02829465.3A Pending CN1658892A (zh) 2002-08-14 2002-08-14 参与蛋白质-蛋白质相互作用的蛋白质亚群的分离方法

Country Status (6)

Country Link
EP (1) EP1556065A4 (ja)
JP (1) JP2005535727A (ja)
CN (1) CN1658892A (ja)
AU (1) AU2002326644A1 (ja)
CA (1) CA2492324A1 (ja)
WO (1) WO2004019967A1 (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3465207T3 (pl) * 2016-05-30 2022-01-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Identyfikacja ligandów przez wspólne frakcjonowanie
CN109932444B (zh) * 2019-03-19 2022-03-11 北京泰德制药股份有限公司 一种糖蛋白多种电荷异构体翻译后修饰的评价方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817789A (en) * 1995-06-06 1998-10-06 Transkaryotic Therapies, Inc. Chimeric proteins for use in transport of a selected substance into cells

Also Published As

Publication number Publication date
JP2005535727A (ja) 2005-11-24
CA2492324A1 (en) 2004-03-11
WO2004019967A1 (en) 2004-03-11
AU2002326644A1 (en) 2004-03-19
EP1556065A4 (en) 2005-10-19
EP1556065A1 (en) 2005-07-27

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication