CN1646369A - 用来制作胶囊的方法和设备 - Google Patents

用来制作胶囊的方法和设备 Download PDF

Info

Publication number
CN1646369A
CN1646369A CNA038083590A CN03808359A CN1646369A CN 1646369 A CN1646369 A CN 1646369A CN A038083590 A CNA038083590 A CN A038083590A CN 03808359 A CN03808359 A CN 03808359A CN 1646369 A CN1646369 A CN 1646369A
Authority
CN
China
Prior art keywords
capsule
recess
film
weld mold
rotation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA038083590A
Other languages
English (en)
Inventor
A·德雷斯
R·格兰姆斯
D·J·史密斯
G·B·泰迪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INGEL TECHNOLOGIES Ltd
Original Assignee
INGEL TECHNOLOGIES Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INGEL TECHNOLOGIES Ltd filed Critical INGEL TECHNOLOGIES Ltd
Publication of CN1646369A publication Critical patent/CN1646369A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/83—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools
    • B29C66/834—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools moving with the parts to be joined
    • B29C66/8341—Roller, cylinder or drum types; Band or belt types; Ball types
    • B29C66/83411—Roller, cylinder or drum types
    • B29C66/83413—Roller, cylinder or drum types cooperating rollers, cylinders or drums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/04—Dielectric heating, e.g. high-frequency welding, i.e. radio frequency welding of plastic materials having dielectric properties, e.g. PVC
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/74—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by welding and severing, or by joining and severing, the severing being performed in the area to be joined, next to the area to be joined, in the joint area or next to the joint area
    • B29C65/743—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by welding and severing, or by joining and severing, the severing being performed in the area to be joined, next to the area to be joined, in the joint area or next to the joint area using the same tool for both joining and severing, said tool being monobloc or formed by several parts mounted together and forming a monobloc
    • B29C65/7435—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by welding and severing, or by joining and severing, the severing being performed in the area to be joined, next to the area to be joined, in the joint area or next to the joint area using the same tool for both joining and severing, said tool being monobloc or formed by several parts mounted together and forming a monobloc the tool being a roller
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/74—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by welding and severing, or by joining and severing, the severing being performed in the area to be joined, next to the area to be joined, in the joint area or next to the joint area
    • B29C65/745—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by welding and severing, or by joining and severing, the severing being performed in the area to be joined, next to the area to be joined, in the joint area or next to the joint area using a single unit having both a severing tool and a welding tool
    • B29C65/7455—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by welding and severing, or by joining and severing, the severing being performed in the area to be joined, next to the area to be joined, in the joint area or next to the joint area using a single unit having both a severing tool and a welding tool the unit being a roller
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/74—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by welding and severing, or by joining and severing, the severing being performed in the area to be joined, next to the area to be joined, in the joint area or next to the joint area
    • B29C65/749—Removing scrap
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B29C66/1122—Single lap to lap joints, i.e. overlap joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/40—General aspects of joining substantially flat articles, e.g. plates, sheets or web-like materials; Making flat seams in tubular or hollow articles; Joining single elements to substantially flat surfaces
    • B29C66/41—Joining substantially flat articles ; Making flat seams in tubular or hollow articles
    • B29C66/43—Joining a relatively small portion of the surface of said articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/737—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the state of the material of the parts to be joined
    • B29C66/7379—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the state of the material of the parts to be joined degradable
    • B29C66/73793—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the state of the material of the parts to be joined degradable soluble, e.g. water-soluble
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/81—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps
    • B29C66/814—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps
    • B29C66/8141—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined
    • B29C66/81431—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined comprising a single cavity, e.g. a groove
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/81—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps
    • B29C66/818—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the cooling constructional aspects, or by the thermal or electrical insulating or conducting constructional aspects of the welding jaws or of the clamps ; comprising means for compensating for the thermal expansion of the welding jaws or of the clamps
    • B29C66/8187—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the cooling constructional aspects, or by the thermal or electrical insulating or conducting constructional aspects of the welding jaws or of the clamps ; comprising means for compensating for the thermal expansion of the welding jaws or of the clamps characterised by the electrical insulating constructional aspects
    • B29C66/81871—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the cooling constructional aspects, or by the thermal or electrical insulating or conducting constructional aspects of the welding jaws or of the clamps ; comprising means for compensating for the thermal expansion of the welding jaws or of the clamps characterised by the electrical insulating constructional aspects of the welding jaws
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/83—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools
    • B29C66/834—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools moving with the parts to be joined
    • B29C66/8341—Roller, cylinder or drum types; Band or belt types; Ball types
    • B29C66/83411—Roller, cylinder or drum types
    • B29C66/83415—Roller, cylinder or drum types the contact angle between said rollers, cylinders or drums and said parts to be joined being a non-zero angle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/83—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools
    • B29C66/834—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools moving with the parts to be joined
    • B29C66/8341—Roller, cylinder or drum types; Band or belt types; Ball types
    • B29C66/83411—Roller, cylinder or drum types
    • B29C66/83417—Roller, cylinder or drum types said rollers, cylinders or drums being hollow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/83—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools
    • B29C66/834—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools moving with the parts to be joined
    • B29C66/8351—Jaws mounted on rollers, cylinders, drums, bands, belts or chains; Flying jaws
    • B29C66/83511—Jaws mounted on rollers, cylinders, drums, bands, belts or chains; Flying jaws jaws mounted on rollers, cylinders or drums
    • B29C66/83513—Jaws mounted on rollers, cylinders, drums, bands, belts or chains; Flying jaws jaws mounted on rollers, cylinders or drums cooperating jaws mounted on rollers, cylinders or drums and moving in a closed path
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/84—Specific machine types or machines suitable for specific applications
    • B29C66/849—Packaging machines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B51/00—Devices for, or methods of, sealing or securing package folds or closures; Devices for gathering or twisting wrappers, or necks of bags
    • B65B51/10—Applying or generating heat or pressure or combinations thereof
    • B65B51/22—Applying or generating heat or pressure or combinations thereof by friction or ultrasonic or high-frequency electrical means, i.e. by friction or ultrasonic or induction welding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B61/00—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B9/00—Enclosing successive articles, or quantities of material, e.g. liquids or semiliquids, in flat, folded, or tubular webs of flexible sheet material; Subdividing filled flexible tubes to form packages
    • B65B9/02—Enclosing successive articles, or quantities of material between opposed webs
    • B65B9/04—Enclosing successive articles, or quantities of material between opposed webs one or both webs being formed with pockets for the reception of the articles, or of the quantities of material
    • B65B9/042—Enclosing successive articles, or quantities of material between opposed webs one or both webs being formed with pockets for the reception of the articles, or of the quantities of material for fluent material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/42—Component parts, details or accessories; Auxiliary operations
    • B29C49/46—Component parts, details or accessories; Auxiliary operations characterised by using particular environment or blow fluids other than air
    • B29C2049/4602—Blowing fluids
    • B29C2049/465—Blowing fluids being incompressible
    • B29C2049/4655—Blowing fluids being incompressible water
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2795/00—Printing on articles made from plastics or substances in a plastic state
    • B29C2795/002—Printing on articles made from plastics or substances in a plastic state before shaping
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/02—Combined blow-moulding and manufacture of the preform or the parison
    • B29C49/06905—Using combined techniques for making the preform
    • B29C49/0691—Using combined techniques for making the preform using sheet like material, e.g. sheet blow-moulding from joined sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/735—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the extensive physical properties of the parts to be joined
    • B29C66/7352—Thickness, e.g. very thin
    • B29C66/73521—Thickness, e.g. very thin of different thickness, i.e. the thickness of one of the parts to be joined being different from the thickness of the other part
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/81—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps
    • B29C66/812—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the composition, by the structure, by the intensive physical properties or by the optical properties of the material constituting the pressing elements, e.g. constituting the welding jaws or clamps
    • B29C66/8122—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the composition, by the structure, by the intensive physical properties or by the optical properties of the material constituting the pressing elements, e.g. constituting the welding jaws or clamps characterised by the composition of the material constituting the pressing elements, e.g. constituting the welding jaws or clamps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/81—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps
    • B29C66/814—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps
    • B29C66/8141—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined
    • B29C66/81411—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat
    • B29C66/81421—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat being convex or concave
    • B29C66/81423—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat being convex or concave being concave
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037—Other properties
    • B29K2995/0059—Degradable
    • B29K2995/0062—Degradable water-soluble
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/712—Containers; Packaging elements or accessories, Packages
    • B29L2031/7174—Capsules
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S53/00—Package making
    • Y10S53/02—High frequency electric sealing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
    • Y10T156/1054—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing and simultaneously bonding [e.g., cut-seaming]

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Containers And Plastic Fillers For Packaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Perforating, Stamping-Out Or Severing By Means Other Than Cutting (AREA)

Abstract

一种胶囊，例如用于分装药物的胶囊，其使用带有凹入部(16)的两个相邻的旋转模具(14，15；42)，使薄膜(18)变形进入凹入部中，由一种可溶于水的聚合物材料的两片薄模(18)生产出，通过使薄膜变形，形成多个凹入部，并且填充这些凹入部。模具(14，15；42)用作被介电焊接把薄膜焊接在一起的电极，为的是形成被填充的胶囊(30)。可以或者通过用一种电绝缘物质(21)涂布模具(14)中的至少一个模具、或者通过把来自模具(14，15；42)的幅板转移到第二对模具，此第二对模具将胶囊(30)切掉，把胶囊(30)与形成的幅板分开。聚合物材料可以是明胶，或者是一种可溶于水的纤维素衍生物，比如羟脯氨酰甲基纤维素，并且聚合物材料也可以包含一种增塑剂。

Description

用来制作胶囊的方法和设备
技术领域
本发明涉及用来形成胶囊的过程和设备，例如用来分装药物，也涉及所形成的胶囊。
背景技术
将多种药物和其它材料分装在胶囊中。可以将液体材料和粉末材料包在软的胶囊中，这些胶囊由一种软的弹性聚合物制成，使这些薄膜在旋转的模具之间合在一起，这些模具在它们表面中有腔室。当薄膜变形成为腔室的形状时，把要填充胶囊的材料提供到薄膜之间；在模具运动的过程中薄膜行进到一起，并且通过在模具上加热和/或加压将薄膜密封在一起。这种旋转模具加工广泛地用于明胶胶囊，模具同时用来对胶囊成形，密封，并且切割出胶囊。
WO 01/68032(Stanelco Fibre Optics)描述了一种使用旋转模具形成胶囊的方法，在该方法中，在模具之间施加射频电压，从而通过介电加热(dielectric heating)把薄膜粘接起来。在这种情况下，不能采用传统的切割技术，这是因为必须保持模具彼此电绝缘。在一种描述过的选择中，把模具闭合起来，围绕着每个胶囊足以留下10到20微米的薄膜厚度。已经发现：在实践中，很难可靠地保持比大约40微米小的狭窄间隙，这是由于轴承的间隙，轴的位置的不精确，以及模具的不圆，特别是在模具可以替换的情况下。
发明内容
按照本发明提供有一种用来制作胶囊的过程，该过程采用两片聚合物材料的薄膜，并且该过程包括如下步骤：将薄膜变形，在一对旋转的焊接模具之间形成多个凹入部，用一种可流动的填充材料填充凹入部，在旋转的焊接模具上通过介电焊接把薄膜焊接在一起，以形成包含填充材料的多个封壳，并且，由薄膜的剩余部分上把被填充的封壳切掉，从而形成多个胶囊，其中，在焊接模具之间没有任何金属对金属的接触，其特征在于，在同一位置实现焊接或者切割，通过使用至少一个焊接模具防止模具之间的金属对金属的接触，或者替代地在与焊接不同的位置进行切割，该模具的外表面涂有一种无孔的电绝缘物质，但是在通过胶囊的在焊接步骤与切割步骤之间的通道胶囊仍然位于凹入部内。
最好，聚合物材料是一种可溶于水或者可食用的材料。对于某些过程可以使用其它的塑料。
本发明也提供了用来进行这样过程的一种设备。
旋转的焊接模具用作相对的电极，将高频电信号提供给这些电极。这种电信号原则上是在1MHz与200MHz之间的频率，常常在10MHz与100MHz之间，但是对于任何发射的无线电波有必须遵守的限制。因此，在实践中，频率的选择可能受到更大的限制。例如，电信号的频率可以为27.12MHz或者40.68MHz。可以通过电容连接装置或者通过滑动接触件例如用电刷实现到两个旋转焊接模具的电连接。
每个旋转模具可以基本上是圆柱形的，并且可以关于一个固定的转动轴旋转，或者转动轴被弹簧加载，使它们彼此靠近。替代地每个旋转模具可以具有基本上多边形的截面，例如八边形，用弹簧对转动轴施加作用力，使它们彼此靠近。可以将模具设置成一次形成一个胶囊，当模具旋转时接续地形成多个凹入部。替代地，可以将模具设置成一次形成多个胶囊，横截着薄膜的宽度并排地排列；例如模具可以形成凹入部的紧密包封的阵列。可以将一个加热器与旋转的模具结合，对薄膜加热，在薄膜变形以形成凹入部之前将薄膜变软。可以通过抽吸到模具的凹入部中使薄膜变形，或者可以用填充材料的压力使薄膜变形、进入那些凹入部中，但是每个凹入部的底部不需要与胶囊的形状相对应，这是因为在形成胶囊的过程中薄膜不需要与凹入部的底部接触。
填充材料可以是一种药物，并且最好是一种液体。在想要吞下胶囊的情况下(例如它们包含一种药物或者一种营养补充剂)，聚合物材料应该是可食用的。它可以例如是明胶，或者是可溶于水的纤维素衍生物，或者是一种淀粉衍生物。例如，它可以是羟脯氨酰甲基纤维素(hydroxypropyl methyl cellulose)，这种物质已经被批准与药物一起使用，并且在食品(在欧洲用编码E464表示)中使用。其它适用的聚合物材料是可食用的海藻衍生的聚合物，比如藻蛋白酸钠(E401)，丙烯乙二醇藻蛋白酸盐(E405)，或者琼脂(E406)。聚合物材料必须不包含任何有害的或者有毒的添加物，但是可以包含一些成分，比如作为增塑剂的甘油(E422)或者单硬脂酸甘油酯(E471)，这些成分也是可食用的，并且可以在水中散布开或者可溶于水。其它适用的纤维素衍生物是羟脯氨酰基纤维素(E463)，以及甲基乙基纤维素(E465)。
不要求任何水添加到薄膜，实际上，最好薄膜至少表面是干燥的，这就是说，与周围条件处于平衡。例如，薄膜可以与温度为25℃、相对湿度为40％的空气处于平衡。例如在使用前可以把它储存在湿度可控的环境中，相对湿度最好在30％到70％的范围内。在这样的环境下，薄膜可能明显地结合一些水，但是表观上完全是干燥的，并且这样的被结合的水会作为一种增塑剂。
在焊接过程中，把薄膜的不同部分加热到不同的温度，并且接续地薄膜幅板当它冷却下来时有变形的趋势。当胶囊通过焊接模具时把胶囊切掉可以避免这一问题，但是，一旦焊接的接缝至少稍微冷却下来，切割过程可能会比较容易。将薄膜幅板转移、并且直接把胶囊装到另一个模具上、从而在整个过程中使胶囊保持在一个或另一个模具的凹入部中，可以确保幅板变形的任何趋势不会对切割过程有不利的影响。在用第二对模具进行切割的情况下，第二对中的一个模具可以是焊接模具中的一个模具，或者替代地，第二对可以是两个另外的模具。
在另一方面，本发明提供了由本发明的方法或设备制成的胶囊。
附图说明
现在将仅只以示例的方式并且参考着附图进一步并且更详细地描述本发明，在附图中：
图1示出了用来形成胶囊的设备的部分为剖面的侧视图；
图2示出了用来形成胶囊的一种替代设备的类似的图；
图3示出了用来形成胶囊的另一种替代设备的类似的图；以及
图4示出了图3的设备的一种改型的类似视图。
具体实施方式
参见图1，该图示意性地示出了用来制作可食用的药物级别材料比如羟脯氨酰甲基(hydroxypropyl methyl)纤维素的设备10，用非水液体的填充材料12填充这些胶囊。该设备包括两个相邻的旋转模具14和15，每个模具有大致圆柱形的外部形状，在它们的周边形成多个椭圆形的凹入部16(如图所示，沿着周边路径有8个凹入部)，使模具14和15的旋转同步，使得凹入部16总是彼此相对。加热器(未示出)布置成将模具14和15保持在50到70℃的温度，例如60℃。由滚轮20将聚合物材料(在本示例中为羟脯氨酰甲基纤维素)的两个薄片18供给到模具14和15，每个薄片18有均匀的厚度0.20毫米。模具14和15有相同的长度，此长度与薄膜18的宽度相同，并且可以具有其它组的沿着它们的长度轴向间隔开的凹入部。将会认识到，围绕周边的凹入部16的数目是可以选择的项目，并且，如果有多于一个凹入部的周边环时，那么这些凹入部16作为模具14和15的表面上的阵列的安排也是可以选择的项目；它们可以例如为紧密排列的阵列。模具14和15是中空的，在它们内部形成与每个凹入部16的底部连通的狭窄管道(未示出)和阀门(未示出)，从而可以对这些凹入部16施加抽吸，这些凹入部紧挨在模具14和15之间的夹紧部位的上方。对模具14和15的旋转轴进行弹簧加载，使它们彼此靠近。从而当薄膜18在模具14和15之间通过时它们受到压缩，并且薄膜布置成使得模具14和15围绕每个凹入部16立即彼此接触。模具15是铝，而模具14主要是铝，但是带有厚度为25微米的电绝缘的氧化铝的表面涂层21。
紧挨在两个模具14和15的上方是一个引导块体22，薄膜18在该引导块体22的下弯曲表面与模具14和15的外表面之间通过。把填充材料12通过引导块体22中的管道24就在薄膜合在一起的那一点的上方泵送到薄膜18之间的间隙中，每个管道24与多组周边凹入部16中的其中一组对准。通过薄膜与模具14和15的加热表面接触使薄膜18变软，并且通过在夹紧点的上方被抽吸到凹入部16中，或者由于填充材料的压力而变形。因此，在这一位置填充材料12填充凹入部16。引导块体22也可以与加热薄膜18的装置结合。
通过电容连接装置27将高频发生器26连接到模具15上，这样产生频率为27.12MHz的电流。通过另一个电容连接装置28和电感装置29把另一个模具14连接到地电位上。电容连接装置28和电感装置29一起形成一个调谐电路，此调谐线路在共振频率的阻抗最小，可以选择电感装置的数值使得共振频率为发生器26的频率(或者接近该频率)。在设备10的运行过程中，发生器26连续地提供这种高频信号，使得当薄膜18在模具14和15之间通过时，对它们实现介电焊接。薄片18的相对的表面变得足够热，以把它们融合在一起，而与模具接触的外表面保持在模具14和15的温度。这样，在运行过程中，当薄膜18通过模具14和15之间的夹紧点时，把薄膜18焊接在一起，并且同时把它们切开。因此，被填充的胶囊30由旋转的模具14和15下面出来。已经将胶囊30由其上切掉的被穿孔的幅板31可以绕着引导滚轮32通过。
因为在焊接过程中聚合物材料熔化，所以围绕着每个胶囊30的内侧面上的焊接接缝形成熔融材料的一个卷边，使得在已经将胶囊切开之后，围绕该接缝壁的厚度稍微厚一点。作为一个示例，每个胶囊30可以具有椭圆体的形状，10毫米长，7毫米宽。考虑到已经证明对于药物应用可以使用这种材料，并且考虑到它可以溶于水和它没有毒性，对于薄片18因此对于胶囊的壁使用一种纤维素的衍生物(比如羟脯氨酰甲基纤维素)具有优点。胶囊30的密封的本质容许材料12是液体，从而用这样的胶囊30可以分装很宽范围的药物。例如，该液体可以是一种有药物活性的材料的溶液，或者是液体形式的药物，或者是一种有药物活性的油或其它液体。将会很容易理解到，填充材料12必定可以与薄片18的材料相容，特别是考虑到纤维素衍生物的高度可溶的性质，所以不希望是水和含水的溶液。填充材料可以替代地是一种自由流动的粉末。
胶囊壁的可溶性意味着胶囊将在病人的胃内很快地破碎，发生药物的快速释放。对于某些应用来说，释放的速度可能是过快了。在这种情况下，或者为了美学上的原因或者味觉和处理上的原因，可以将胶囊嵌在附加的材料中，比如为了改善味觉的糖涂层，或者为了减慢释放速度的一种溶解度较低的涂层。
对于上面描述的设备可以实现许多变化和改进，而不偏离本发明的范围。例如，可以在一次操作中把三片薄片焊接在一起，在外薄片中带有凹入部，从而可以生产出两个腔室的胶囊，在该胶囊中每个腔室装着一种不同的材料。药物级的纤维素衍生物是高度优选的，但是也可以使用其它材料比如明胶。薄膜可以具有不同的厚度，典型地在100到600微米的范围内。用某些薄膜，加热模具14和15可能是不必要的。并且，可以通过弹簧接触或者电刷而不是通过电容连接装置27和28实现对焊接模具14和15的电接触。进而，可以省略电感装置29。通过连接装置28直接把模具14连接到地；并且可以在发生器26与连接到模具15上的连接装置27之间设置一个匹配的网络，从而将对于发生器26给出的阻抗保持为常数。绝缘涂层21可以为不同的材料，最好为一种不能被介电加热的材料，例如PFA(全氟烷氧基烷)。其它适用的聚合物材料是聚四氟乙烯(PTFE)，或者氟化乙丙烯(FEP)，或者聚醚-醚-酮(PEEK)。另一种适用的材料是电绝缘的金刚石状的碳(DLC)。涂层21的厚度典型地在10到100微米的范围内。
现在参见图2，该图示出了一种设备40，它与图1的设备非常类似，许多部件是相同的，并且用相同的附图标记表示。在这种情况下，焊接电极或模具42是相同的，两个模具都是不锈钢的，并且形成凹入部16。它们的安装方式使得在模具最靠近的位置保持模具42被薄膜18分开，最靠近的距离为0.2毫米(从而在焊接过程中把每片厚度为0.2毫米的薄膜18压在一起)。如用设备10那样，当薄膜18通过夹紧点时，薄膜经受介电焊接，由焊接的薄膜18的一个幅板连接在一起的被填充的胶囊30的一个阵列由夹紧点出来，但是仍然保持位于左手模具42上的凹入部16中(如图所示)。
在夹紧点下面设置一台冲压机44，把它安装在与左手模具42同圆心的弧形轨道46上，用一个机构(未示出)操纵该冲压机，当它冲压出胶囊30(或者胶囊30的轴向上的一排)时以与模具42相同的角速度沿着轨道46向下运动。随后冲压机44缩回，并且沿着轨道46返回向上运动，到达它的开始位置，准备好冲压下一个胶囊30。随后，被穿孔的幅板31在滚轮48上通过。在这种情况下进一步的特点在于：将一个印刷站49设置在紧靠着滚轮28的下面，把信息印刷到其中一个薄片18上。
设备40以与设备10相同的方式工作，但是因为直到胶囊30围绕着模具42越过夹紧点进一步行进一段距离之后还没有切断胶囊30，所以在焊接步骤之后薄膜18的聚合物材料已经降低了温度，因此焊缝有足够的时间牢固地粘接在一起。将会认识到，焊接的模具42可以为不同的材料，例如可以是黄铜或者铝。在冲压机44的位置，可以用超声切割机或者激光切割机把胶囊30切掉。
现在参见图3，该图示出了一种设备50，它与图2的设备40并且与图1的装置非常类似，许多部件是相同的，并且用相同的附图标记表示。在这种情况下，焊接机构包括电极或模具42与图2的设备相同，模具42仍然是不锈钢的。把一个不锈钢的接触切割滚轮52安装在左手模具42的下面，形成有锋利边缘54的凹入部16。接触切割滚轮52足够地靠近，使得它刚好围绕着每个凹入部16的边缘与左手模具42接触，从而把胶囊30切掉。最好在电路上也把接触切割滚轮52连接到左手模具42上。随后，被穿孔的幅板31穿过滚轮48。
设备50以与设备40基本上相同的方式工作。因为切掉必须需要左手模具42与接触切割滚轮52之间的接触，所以这种布置仅只如果左手模具42是刚硬的耐磨损材料时可以应用。
现在参见图4，该图示出了一种设备60，它与图3的设备有许多类似之处，许多部件是相同的，并且用相同的附图标记表示。在这种情况下，焊接机构包括电极或模具42与图2和3的装置相同，但是在这种情况下如果需要模具42可以是不是不锈钢的材料。把一个不锈钢的转移滚轮62安装在左手模具42的下面，形成放置胶囊30的凹入部16。对在发生转移的位置将部分的真空施加到转移滚轮62内的凹入部16可能是希望的。转移滚轮62不与模具42接触。
靠在转移滚轮62的旁边设置一个接触切割滚轮64，它形成带有锋利边缘54的凹入部16。接触切割滚轮64足够地靠近，使得当两个滚轮旋转时接触切割滚轮刚好围绕着每个凹入部16的边缘与转移滚轮62接触，从而把胶囊30切掉。随后，被穿孔的幅板31穿过滚轮54。
设备60如在前面描述的设备中那样将胶囊30焊接起来，并且容许在切割之前有时间使焊缝牢固地粘接起来。与前面的设计相比，设备60有焊接模具42可以为任何所希望的材料的好处，因为它们没有被包括在切割过程中。第二个好处是：焊接与切割之间的时间延迟比用前面的设计更长。而第三个好处是：切割机构(转移滚轮62和接触切割滚轮64)与两个焊接电极(模具42)在电路上绝缘。
将会认识到，可以以多种方式改进上面所描述的设备。特别是，已经示出的凹入部在每种情况下有一个弯曲的底部，把它的形状做成与胶囊30的形状一致。在焊接模具42中这可能是优选的(尽管在那里这不是必须的)，并且一旦胶囊30已经形成，这就不需要。因此，在图3的接触切割滚轮52中的凹入部16，以及在图4的转移滚轮62和接触切割滚轮64中的凹入部16可以替代地是平底的凹入部。

Claims (9)

1.一种用来制作胶囊的过程，该过程采用两片聚合物材料的薄膜，并且该过程包括如下步骤：将薄膜变形，以在一对旋转的焊接模具之间形成多个凹入部，用可流动的填充材料填充该凹入部，在旋转的焊接模具上通过介电焊接把薄膜焊接在一起，以形成包含填充材料的多个封壳，并且，从薄膜的剩余部分上把被填充的封壳切掉，从而形成多个胶囊，其中，在焊接模具之间没有任何金属对金属的接触，且其特征在于，在同一位置实现焊接或者切割，通过使用至少一个焊接模具防止模具之间的金属对金属的接触，该模具的外表面涂有一种无孔的电绝缘物质或者替代地在与焊接不同的位置进行切割，但是贯穿胶囊的在焊接步骤与切割步骤之间通道胶囊仍然位于凹入部内。
2.按照权利要求1所述的过程，其特征在于，在一对旋转的切割模具之间进行切割。
3.按照权利要求2所述的过程，其特征在于，其中一个旋转的切割模具是其中一个旋转的焊接模具。
4.按照权利要求2所述的过程，其特征在于，该对旋转的切割模具与旋转的焊接模具分开，但是邻近旋转的焊接模具，从而胶囊首先位于其中一个旋转的焊接模具的凹入部中，且随后在切割步骤之前位于其中一个旋转的切割模具的凹入部中。
5.一种用来由两片聚合物材料的薄膜制作胶囊的设备，该设备包括形成凹入部的一对旋转的焊接模具，把薄膜提供给到焊接模具的装置，使得薄膜变形，形成凹入部，以及用填充材料填充在薄膜中形成的凹入部的装置，以及在焊接模具之间施加高频电信号的装置，从而通过介电焊接把薄膜焊接在一起，以形成包含填充材料的多个封壳，以及由薄膜的剩余部分上把被填充的封壳切掉的装置，从而形成多个胶囊，其中，在焊接模具之间没有任何金属对金属的接触，且其特征在于，在同一位置实现焊接或者切割，通过使用至少一个焊接模具防止模具之间的金属对金属的接触，该模具的外表面涂有一种无孔的电绝缘物质，或者替代地在与焊接不同的位置进行切割，但是在贯穿胶囊的在焊接步骤与切割步骤之间的通道胶囊仍然位于凹入部内。
6.按照权利要求5所述的设备，其特征在于，电绝缘物质是陶瓷。
7.按照权利要求5所述的设备，其特征在于，在封壳仍然位于其中一个焊接模具的凹入部中的同时进行切割。
8.按照权利要求7所述的设备，其特征在于，由邻近焊接模具的接触切割滚轮实现切割。
9.按照权利要求5所述的设备，其特征在于，其还包括转移滚轮和接触切割滚轮，封壳位于转移滚轮的凹入部中，并且在转移滚轮与接触切割滚轮之间进行切割。
CNA038083590A 2002-04-13 2003-04-01 用来制作胶囊的方法和设备 Pending CN1646369A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0208587.6A GB0208587D0 (en) 2002-04-13 2002-04-13 Capsules
GB0208587.6 2002-04-13

Publications (1)

Publication Number Publication Date
CN1646369A true CN1646369A (zh) 2005-07-27

Family

ID=9934839

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038083590A Pending CN1646369A (zh) 2002-04-13 2003-04-01 用来制作胶囊的方法和设备

Country Status (24)

Country Link
US (1) US7490456B2 (zh)
EP (1) EP1497175B1 (zh)
JP (1) JP2005522302A (zh)
KR (1) KR20050013101A (zh)
CN (1) CN1646369A (zh)
AT (1) ATE327156T1 (zh)
AU (1) AU2003214471A1 (zh)
BR (1) BR0309124A (zh)
CA (1) CA2481100A1 (zh)
DE (1) DE60305475T2 (zh)
DK (1) DK1497175T3 (zh)
ES (1) ES2262982T3 (zh)
GB (1) GB0208587D0 (zh)
HK (1) HK1074429A1 (zh)
IL (2) IL164213A0 (zh)
MX (1) MXPA04010075A (zh)
MY (1) MY134390A (zh)
NO (1) NO20044229L (zh)
NZ (1) NZ535693A (zh)
PL (1) PL371421A1 (zh)
PT (1) PT1497175E (zh)
RU (1) RU2004133343A (zh)
WO (1) WO2003089302A1 (zh)
ZA (1) ZA200407656B (zh)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106428702A (zh) * 2016-10-15 2017-02-22 衢州乐创节能科技有限公司 一种卷膜封袋柑桔包装机
CN107487469A (zh) * 2017-08-10 2017-12-19 青岛康桥知识产权有限公司 一种袋装水的自动灌装设备、灌装方法及专用袋体
CN110150985A (zh) * 2019-05-05 2019-08-23 深圳市道中创新科技有限公司 一种萃取装置及自动售卖机
CN111251521A (zh) * 2018-12-03 2020-06-09 沈欣 液态珠丸的制造模具和制造方法
CN111249992A (zh) * 2018-12-03 2020-06-09 沈欣 液态珠丸的制造方法
CN111661407A (zh) * 2020-04-28 2020-09-15 天津泉洁科技有限公司 一种袋装水自动售水机
CN112702934A (zh) * 2018-09-14 2021-04-23 欧莱雅 用于制造囊状部的方法和相关系统
CN114084394A (zh) * 2021-11-22 2022-02-25 浙江海洋大学 一种水产品的塑料封装装置

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2414978A (en) * 2004-05-18 2005-12-14 Stanelco Fibre Optics Ltd Capsule-making apparatus and method
GB2415163A (en) * 2004-06-19 2005-12-21 Reckitt Benckiser Nv A process for preparing a water-soluble container
US7621734B2 (en) * 2004-07-28 2009-11-24 Mars, Incorporated Apparatus and process for preparing confectionery having an inclusion therein using forming rolls and a forming pin
GB2416750A (en) * 2004-08-02 2006-02-08 Bioprogress Technology Ltd Encapsulation of liquids
GB2423974B (en) * 2005-03-08 2009-08-26 Ingel Technologies Ltd Making capsules
GB2423975B (en) * 2005-03-08 2009-08-26 Ingel Technologies Ltd Capsules
GB2429451B (en) * 2005-08-25 2008-03-26 Stanelco Rf Technologies Ltd Gas absorbing means for a container
US8739698B2 (en) 2007-07-30 2014-06-03 Procaps S.A. Method and apparatus for printing on soft gelatin capsules during forming
US20090060983A1 (en) * 2007-08-30 2009-03-05 Bunick Frank J Method And Composition For Making An Orally Disintegrating Dosage Form
AU2008318851B2 (en) * 2007-10-31 2014-04-17 Mcneil-Ppc, Inc. Orally disintegrated dosage form
CA2737880A1 (en) * 2008-09-26 2010-04-01 Sankyo Co., Ltd. Method for manufacturing soft capsule and apparatus for manufacturing the same
US20110070301A1 (en) * 2009-09-24 2011-03-24 Luber Joseph R Orally transformable tablets
US20110070286A1 (en) * 2009-09-24 2011-03-24 Andreas Hugerth Process for the manufacture of nicotine-comprising chewing gum and nicotine-comprising chewing gum manufactured according to said process
US20110318411A1 (en) * 2010-06-24 2011-12-29 Luber Joseph R Multi-layered orally disintegrating tablet and the manufacture thereof
DK2552788T3 (en) * 2010-03-26 2015-11-16 Philip Morris Products Sa Væskedispensersystem for use in the formation of a tobacco product in the pouch.
AU2011306064B2 (en) * 2010-09-22 2015-03-12 Mcneil-Ppc, Inc Manufacture of variable density dosage forms utilizing radiofrequency energy
KR101201175B1 (ko) 2010-11-05 2012-11-13 김경란 구형물 성형장치
US9511028B2 (en) 2012-05-01 2016-12-06 Johnson & Johnson Consumer Inc. Orally disintegrating tablet
US9233491B2 (en) 2012-05-01 2016-01-12 Johnson & Johnson Consumer Inc. Machine for production of solid dosage forms
US9445971B2 (en) 2012-05-01 2016-09-20 Johnson & Johnson Consumer Inc. Method of manufacturing solid dosage form
BR112014032130A2 (pt) * 2012-06-23 2017-06-27 Rideau Machinery Inc aprimoramentos em formação rotativa de movimento contínuo de bolsas solúveis
KR200462191Y1 (ko) 2012-07-03 2012-08-29 박종술 약캡슐 제조롤러
FR2993864B1 (fr) * 2012-07-27 2015-04-24 Polytek Innovations Procede et machine de formation de capsules contenant un fluide.
KR101268491B1 (ko) 2013-01-11 2013-06-04 정수영 캡슐 포장장치
GB2529599B (en) * 2013-05-23 2017-02-15 Barlean's Organic Oils Llc Rotary die system
EP3091966B1 (en) 2014-01-10 2019-07-31 Johnson & Johnson Consumer Inc. Process for making tablet using radiofrequency and lossy coated particles
FR3018268B1 (fr) * 2014-03-07 2016-03-11 Polytek Innovations Procede et installation de fabrication de capsule
JP6396500B2 (ja) * 2014-05-21 2018-09-26 ザ プロクター アンド ギャンブル カンパニー 組成物を分配するための方法及びシステム
AU2015339245B2 (en) 2014-10-31 2019-05-16 Barlean's Organic Oils, Llc Method and apparatus for the manufacture of softgels
EP3053834B1 (en) * 2015-02-04 2019-03-27 Tetra Laval Holdings & Finance S.A. Forming assembly and method for forming a plurality of sealed packs for pourable food products starting from a tube of packaging material
RU2760374C2 (ru) 2016-12-23 2021-11-24 Р.П. Шерер Текнолоджис, Ллс Матрица для мягких гелевых капсул с несколькими наполнителями/отделениями
IT201700019105A1 (it) * 2017-02-21 2018-08-21 Azionaria Costruzioni Macch Automatiche A C M A Macchina per la realizzazione di pasta ripiena
IT201700019144A1 (it) * 2017-02-21 2018-08-21 Azionaria Costruzioni Acma Spa Macchina per la realizzazione di pasta ripiena.
US10493026B2 (en) 2017-03-20 2019-12-03 Johnson & Johnson Consumer Inc. Process for making tablet using radiofrequency and lossy coated particles
GB2569266A (en) * 2017-10-13 2019-06-19 Nottingham Univ Hospitals Nhs Trust Methods of forming solid or liquid charged capsules
CA3069207C (en) * 2019-05-01 2022-10-18 Paul Lukas Methods and systems for laser marking pharmaceutical capsules during manufacturing

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2497212A (en) * 1945-10-31 1950-02-14 Alfonso M Donofrio Method of manufacturing capsules
FR1204696A (fr) 1958-06-10 1960-01-27 Procédé de fabrication d'emballages en matière thermosoudable et dispositif pour sa mise en oeuvre
US3269088A (en) * 1963-09-09 1966-08-30 Scherer Corp R P Apparatus for making fluid filled capsules
CA1081418A (en) * 1975-12-24 1980-07-15 Ivan Lestan Method and apparatus for producing foamed articles
US4281763A (en) * 1979-10-31 1981-08-04 Pace Joseph A Two-piece hardshell, soluble and digestible liquid containing gelatin capsule
US4820364A (en) * 1983-05-23 1989-04-11 Capsulbond Incorporated Method for sealing capsules
US4662155A (en) * 1983-10-06 1987-05-05 Chasman Sydney A Method and apparatus for forming capsules
US4599125A (en) * 1984-08-03 1986-07-08 Buck Byron L Method and system for forming sheet material into apertured shapes
DE3600084A1 (de) * 1986-01-03 1987-07-09 Scherer Gmbh R P Formkoerper sowie verfahren und vorrichtung zur herstellung eines solchen formkoerpers
US4844906A (en) * 1987-03-25 1989-07-04 Kv Pharmaceutical Company Tamper evident pharmaceutical capsule
US4782647A (en) * 1987-10-08 1988-11-08 Becton, Dickinson And Company Flexible packaging and the method of production
DE4024070A1 (de) * 1990-07-28 1992-01-30 Krauss Maffei Ag Einrichtung zum plastifizieren von thermoplastischen kunststoffen
US5427645A (en) * 1991-12-09 1995-06-27 W. R. Grace & Co.-Conn. Apparatus and method for radio frequency sealing thermoplastic films together
GB9821620D0 (en) * 1998-10-06 1998-11-25 Stanelco Fibre Optics Ltd Capsules
GB0006432D0 (en) * 2000-03-17 2000-05-03 Stanelco Fibre Optics Ltd Capsules
GB0006430D0 (en) 2000-03-17 2000-05-03 Stanelco Fibre Optics Ltd Capsules
US6949154B2 (en) * 2001-07-28 2005-09-27 Boehringer Ingelheim Pharma Kg Method and apparatus for sealing medicinal capsules

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106428702A (zh) * 2016-10-15 2017-02-22 衢州乐创节能科技有限公司 一种卷膜封袋柑桔包装机
CN107487469A (zh) * 2017-08-10 2017-12-19 青岛康桥知识产权有限公司 一种袋装水的自动灌装设备、灌装方法及专用袋体
CN107487469B (zh) * 2017-08-10 2020-05-12 范宗军 一种袋装水的自动灌装设备、灌装方法
CN112702934A (zh) * 2018-09-14 2021-04-23 欧莱雅 用于制造囊状部的方法和相关系统
CN112702934B (zh) * 2018-09-14 2023-10-20 欧莱雅 用于制造囊状部的方法和相关系统
CN111251521A (zh) * 2018-12-03 2020-06-09 沈欣 液态珠丸的制造模具和制造方法
CN111249992A (zh) * 2018-12-03 2020-06-09 沈欣 液态珠丸的制造方法
CN110150985A (zh) * 2019-05-05 2019-08-23 深圳市道中创新科技有限公司 一种萃取装置及自动售卖机
CN110150985B (zh) * 2019-05-05 2021-06-08 深圳市道中创新科技有限公司 一种萃取装置及自动售卖机
CN111661407A (zh) * 2020-04-28 2020-09-15 天津泉洁科技有限公司 一种袋装水自动售水机
CN111661407B (zh) * 2020-04-28 2022-04-12 天津泉洁科技有限公司 一种袋装水自动售水机
CN114084394A (zh) * 2021-11-22 2022-02-25 浙江海洋大学 一种水产品的塑料封装装置

Also Published As

Publication number Publication date
PL371421A1 (en) 2005-06-13
IL164213A0 (en) 2005-12-18
ES2262982T3 (es) 2006-12-01
AU2003214471A1 (en) 2003-11-03
GB0208587D0 (en) 2002-05-22
DE60305475D1 (de) 2006-06-29
ZA200407656B (en) 2006-07-26
NO20044229L (no) 2004-10-06
ATE327156T1 (de) 2006-06-15
DK1497175T3 (da) 2006-06-26
DE60305475T2 (de) 2006-11-23
JP2005522302A (ja) 2005-07-28
HK1074429A1 (en) 2005-11-11
PT1497175E (pt) 2006-09-29
BR0309124A (pt) 2005-02-01
EP1497175A1 (en) 2005-01-19
RU2004133343A (ru) 2005-05-10
NZ535693A (en) 2005-11-25
WO2003089302A1 (en) 2003-10-30
IL164213A (en) 2009-02-11
MXPA04010075A (es) 2005-08-15
EP1497175B1 (en) 2006-05-24
CA2481100A1 (en) 2003-10-30
US20050138899A1 (en) 2005-06-30
KR20050013101A (ko) 2005-02-02
MY134390A (en) 2007-12-31
US7490456B2 (en) 2009-02-17

Similar Documents

Publication Publication Date Title
CN1646369A (zh) 用来制作胶囊的方法和设备
US6755010B2 (en) Capsules
US6923980B2 (en) Capsules
GB2414978A (en) Capsule-making apparatus and method
CN1202796C (zh) 用聚合材料薄膜制造胶囊的方法以及胶囊
GB2423974A (en) Making capsules by dielectric welding
GB2423975A (en) Making capsules by dielectric welding

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication