CN1634452A - 养阴清肺滴丸 - Google Patents
养阴清肺滴丸 Download PDFInfo
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- CN1634452A CN1634452A CN 200410090957 CN200410090957A CN1634452A CN 1634452 A CN1634452 A CN 1634452A CN 200410090957 CN200410090957 CN 200410090957 CN 200410090957 A CN200410090957 A CN 200410090957A CN 1634452 A CN1634452 A CN 1634452A
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- polyethylene glycol
- mixed
- yin
- radix
- nourishing
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- 239000006187 pill Substances 0.000 title claims abstract description 58
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- 238000000034 method Methods 0.000 claims abstract description 21
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- 206010068319 Oropharyngeal pain Diseases 0.000 claims abstract description 3
- 201000007100 Pharyngitis Diseases 0.000 claims abstract description 3
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- 239000002202 Polyethylene glycol Substances 0.000 claims description 90
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 31
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 31
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 31
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 31
- 229960004853 betadex Drugs 0.000 claims description 31
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 31
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 9
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 9
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- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 9
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 claims description 9
- 239000008117 stearic acid Substances 0.000 claims description 9
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 235000015424 sodium Nutrition 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 206010036790 Productive cough Diseases 0.000 claims description 5
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- 210000003026 hypopharynx Anatomy 0.000 claims description 5
- 208000024794 sputum Diseases 0.000 claims description 5
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- 238000000605 extraction Methods 0.000 claims description 4
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 4
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- 239000004353 Polyethylene glycol 8000 Substances 0.000 description 6
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- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 206010070840 Gastrointestinal tract irritation Diseases 0.000 description 1
- 102000000340 Glucosyltransferases Human genes 0.000 description 1
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- 239000000084 colloidal system Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
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- 235000019425 dextrin Nutrition 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 125000002791 glucosyl group Chemical class C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
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- 210000004185 liver Anatomy 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000029052 metamorphosis Effects 0.000 description 1
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- 238000000465 moulding Methods 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
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- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
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- FDRCDNZGSXJAFP-UHFFFAOYSA-M sodium chloroacetate Chemical compound [Na+].[O-]C(=O)CCl FDRCDNZGSXJAFP-UHFFFAOYSA-M 0.000 description 1
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Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
聚乙二醇2000 | 50.0 | 61 | <30 | >10 | + |
聚乙二醇4000 | 50.0 | 78 | <30 | >10 | ++ |
聚乙二醇6000 | 50.0 | 79 | <30 | >10 | ++ |
聚乙二醇8000 | 50.0 | 78 | <30 | >10 | ++ |
聚乙二醇10000 | 50.0 | 80 | <30 | >10 | ++ |
聚乙二醇20000 | 50.0 | 81 | <30 | >10 | ++ |
硬脂酸聚烃氧40酯 | 50.0 | 76 | <30 | >10 | ++ |
倍他环糊精 | 50.0 | 66 | <30 | >10 | + |
泊洛沙姆 | 50.0 | 73 | <30 | >10 | ++ |
羧甲基淀粉钠 | 50.0 | 71 | <30 | >10 | + |
十二烷基硫酸钠 | 50.0 | 66 | >30 | >10 | ++ |
硬脂酸 | 50.0 | 53 | >30 | >10 | +++ |
硬脂酸钠 | 50.0 | 54 | >30 | >10 | +++ |
甘油明胶 | 50.0 | 54 | >30 | >10 | +++ |
虫胶 | 50.0 | 50 | >30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
聚乙二醇2000 | 25.0 | 77 | <30 | >10 | ++ |
聚乙二醇4000 | 25.0 | 85 | <30 | <10 | ++ |
聚乙二醇6000 | 25.0 | 91 | <30 | <10 | +++ |
聚乙二醇8000 | 25.0 | 90 | <30 | <10 | +++ |
聚乙二醇10000 | 25.0 | 90 | <30 | <10 | +++ |
聚乙二醇20000 | 25.0 | 91 | <30 | <10 | ++ |
硬脂酸聚烃氧40酯 | 25.0 | 93 | <30 | <10 | ++ |
倍他环糊精 | 25.0 | 81 | <30 | >10 | ++ |
泊洛沙姆 | 25.0 | 88 | <30 | <10 | +++ |
羧甲基淀粉钠 | 25.0 | 82 | <30 | >10 | ++ |
十二烷基硫酸钠 | 25.0 | 76 | <30 | >10 | ++ |
硬脂酸 | 25.0 | 70 | >30 | >10 | +++ |
硬脂酸钠 | 25.0 | 71 | >30 | >10 | +++ |
甘油明胶 | 25.0 | 69 | >30 | >10 | +++ |
虫胶 | 25.0 | 68 | >30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
聚乙二醇2000 | 10.0 | 82 | <30 | >10 | ++ |
聚乙二醇4000 | 10.0 | 89 | <30 | <10 | +++ |
聚乙二醇6000 | 10.0 | 93 | <30 | <10 | +++ |
聚乙二醇8000 | 10.0 | 92 | <30 | <10 | +++ |
聚乙二醇10000 | 10.0 | 93 | <30 | <10 | +++ |
聚乙二醇20000 | 10.0 | 94 | <30 | <10 | +++ |
硬脂酸聚烃氧40酯 | 10.0 | 89 | <30 | <10 | ++ |
倍他环糊精 | 10.0 | 87 | <30 | <10 | ++ |
泊洛沙姆 | 10.0 | 93 | <30 | <10 | +++ |
羧甲基淀粉钠 | 10.0 | 82 | <30 | >10 | +++ |
十二烷基硫酸钠 | 10.0 | 82 | <30 | >10 | +++ |
硬脂酸 | 10.0 | 78 | >30 | >10 | +++ |
硬脂酸钠 | 10.0 | 80 | >30 | >10 | +++ |
甘油明胶 | 10.0 | 73 | >30 | >10 | +++ |
虫胶 | 10.0 | 76 | >30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶1 | 50 | 83 | <30 | >10 | ++ |
泊洛沙姆∶聚乙二醇=1∶1 | 50 | 82 | <30 | >10 | ++ |
羧甲基淀粉钠∶聚乙二醇=1∶1 | 50 | 78 | <30 | >10 | ++ |
倍他环糊精∶聚乙二醇=1∶1 | 50 | 73 | <30 | >10 | + |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶1 | 25 | 89 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶1 | 25 | 90 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶1 | 25 | 86 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶1 | 25 | 82 | <30 | >10 | ++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶1 | 10 | 88 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶1 | 10 | 85 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶1 | 10 | 82 | <30 | >10 | +++ |
倍他环糊精∶聚乙二醇=1∶1 | 10 | 80 | <30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶5 | 50 | 92 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶5 | 50 | 93 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶5 | 50 | 86 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶5 | 50 | 82 | <30 | >10 | ++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶5 | 25 | 91 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶5 | 25 | 91 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶5 | 25 | 89 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶5 | 25 | 86 | <30 | <10 | ++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶5 | 10 | 95 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶5 | 10 | 93 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶5 | 10 | 90 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶5 | 10 | 88 | <30 | <10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶10 | 50 | 92 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶10 | 50 | 91 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶10 | 50 | 87 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶10 | 50 | 84 | <30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶10 | 25 | 92 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶10 | 25 | 92 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶10 | 25 | 89 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶10 | 25 | 87 | <30 | <10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶10 | 10 | 91 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶10 | 10 | 92 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶10 | 10 | 91 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶10 | 10 | 91 | <30 | <10 | +++ |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100909576A CN100367934C (zh) | 2004-11-12 | 2004-11-12 | 养阴清肺滴丸 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100909576A CN100367934C (zh) | 2004-11-12 | 2004-11-12 | 养阴清肺滴丸 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1634452A true CN1634452A (zh) | 2005-07-06 |
CN100367934C CN100367934C (zh) | 2008-02-13 |
Family
ID=34847617
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100909576A Expired - Fee Related CN100367934C (zh) | 2004-11-12 | 2004-11-12 | 养阴清肺滴丸 |
Country Status (1)
Country | Link |
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CN (1) | CN100367934C (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103893527A (zh) * | 2012-12-28 | 2014-07-02 | 天津中新药业研究中心 | 一种养阴清肺清热利咽的中药组合物及其制备方法 |
CN103893525A (zh) * | 2012-12-28 | 2014-07-02 | 天津中新药业研究中心 | 一种养阴清肺清热利咽的中药组合物的制备工艺 |
CN103893528A (zh) * | 2012-12-28 | 2014-07-02 | 天津中新药业研究中心 | 一种养阴清肺清热利咽的中药组合物和制备方法 |
CN103893526A (zh) * | 2012-12-28 | 2014-07-02 | 天津中新药业研究中心 | 一种养阴清肺清热利咽的中药组合物的制备方法 |
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CN103893527A (zh) * | 2012-12-28 | 2014-07-02 | 天津中新药业研究中心 | 一种养阴清肺清热利咽的中药组合物及其制备方法 |
CN103893525A (zh) * | 2012-12-28 | 2014-07-02 | 天津中新药业研究中心 | 一种养阴清肺清热利咽的中药组合物的制备工艺 |
CN103893528A (zh) * | 2012-12-28 | 2014-07-02 | 天津中新药业研究中心 | 一种养阴清肺清热利咽的中药组合物和制备方法 |
CN103893526A (zh) * | 2012-12-28 | 2014-07-02 | 天津中新药业研究中心 | 一种养阴清肺清热利咽的中药组合物的制备方法 |
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