CN1679669A - 远志滴丸及其制备方法 - Google Patents
远志滴丸及其制备方法 Download PDFInfo
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- CN1679669A CN1679669A CN 200510002878 CN200510002878A CN1679669A CN 1679669 A CN1679669 A CN 1679669A CN 200510002878 CN200510002878 CN 200510002878 CN 200510002878 A CN200510002878 A CN 200510002878A CN 1679669 A CN1679669 A CN 1679669A
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- polyethylene glycol
- extractum
- drug extract
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- 238000002360 preparation method Methods 0.000 title claims description 37
- 241000208966 Polygala Species 0.000 title abstract 3
- 239000006187 pill Substances 0.000 claims abstract description 63
- 239000003814 drug Substances 0.000 claims description 105
- 239000002202 Polyethylene glycol Substances 0.000 claims description 101
- 229920001223 polyethylene glycol Polymers 0.000 claims description 101
- 229940079593 drug Drugs 0.000 claims description 90
- 239000000284 extract Substances 0.000 claims description 84
- 239000000758 substrate Substances 0.000 claims description 42
- -1 polyoxyethylene stearate Polymers 0.000 claims description 37
- 229920002472 Starch Polymers 0.000 claims description 35
- 235000019698 starch Nutrition 0.000 claims description 35
- 239000008107 starch Substances 0.000 claims description 35
- 229920000858 Cyclodextrin Polymers 0.000 claims description 32
- 239000001116 FEMA 4028 Substances 0.000 claims description 32
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 32
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 32
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 32
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 32
- 229960004853 betadex Drugs 0.000 claims description 32
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 32
- 229920001983 poloxamer Polymers 0.000 claims description 32
- 229960000502 poloxamer Drugs 0.000 claims description 32
- 239000011734 sodium Substances 0.000 claims description 32
- 229910052708 sodium Inorganic materials 0.000 claims description 32
- 241000146384 Glaux Species 0.000 claims description 31
- 150000002148 esters Chemical class 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 20
- 239000012530 fluid Substances 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 17
- 239000004615 ingredient Substances 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 11
- 238000005325 percolation Methods 0.000 claims description 11
- 239000001828 Gelatine Substances 0.000 claims description 10
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 10
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 10
- 235000021355 Stearic acid Nutrition 0.000 claims description 10
- 229920000159 gelatin Polymers 0.000 claims description 10
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- 235000011187 glycerol Nutrition 0.000 claims description 10
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 10
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 10
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 claims description 10
- 239000008117 stearic acid Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 235000015424 sodium Nutrition 0.000 claims description 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 6
- 206010036790 Productive cough Diseases 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
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- 239000000243 solution Substances 0.000 claims description 4
- 239000010017 yuan zhi Substances 0.000 claims description 4
- 229910021529 ammonia Inorganic materials 0.000 claims description 3
- 238000005352 clarification Methods 0.000 claims description 3
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- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 229940057995 liquid paraffin Drugs 0.000 claims description 2
- 229920002545 silicone oil Polymers 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 238000009413 insulation Methods 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 abstract description 7
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- 239000000969 carrier Substances 0.000 description 9
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- 239000004353 Polyethylene glycol 8000 Substances 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 239000000428 dust Substances 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 3
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- 239000002552 dosage form Substances 0.000 description 3
- 238000010579 first pass effect Methods 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
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- 230000000857 drug effect Effects 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 235000015250 liver sausages Nutrition 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 206010070840 Gastrointestinal tract irritation Diseases 0.000 description 1
- 102000000340 Glucosyltransferases Human genes 0.000 description 1
- 108010055629 Glucosyltransferases Proteins 0.000 description 1
- 241001640034 Heteropterys Species 0.000 description 1
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
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- 230000007812 deficiency Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 125000002791 glucosyl group Chemical class C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000029052 metamorphosis Effects 0.000 description 1
- 239000004531 microgranule Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 239000000820 nonprescription drug Substances 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- FDRCDNZGSXJAFP-UHFFFAOYSA-M sodium chloroacetate Chemical compound [Na+].[O-]C(=O)CCl FDRCDNZGSXJAFP-UHFFFAOYSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
聚乙二醇1000 | 50.0 | 80 | <30 | >10 | + |
聚乙二醇2000 | 50.0 | 80 | <30 | >10 | + |
聚乙二醇4000 | 50.0 | 88 | <30 | >10 | ++ |
聚乙二醇6000 | 50.0 | 82 | <30 | >10 | ++ |
聚乙二醇8000 | 50.0 | 79 | <30 | >10 | ++ |
聚乙二醇9300 | 50.0 | 88 | <30 | >10 | ++ |
聚乙二醇10000 | 50.0 | 80 | <30 | >10 | ++ |
聚乙二醇20000 | 50.0 | 80 | <30 | >10 | ++ |
硬脂酸聚烃氧40酯 | 50.0 | 78 | <30 | >10 | ++ |
倍他环糊精 | 50.0 | 72 | <30 | >10 | + |
泊洛沙姆 | 50.0 | 79 | <30 | >10 | ++ |
羧甲基淀粉钠 | 50.0 | 73 | <30 | >10 | + |
十二烷基硫酸钠 | 50.0 | 68 | >30 | >10 | ++ |
硬脂酸 | 50.0 | 55 | >30 | >10 | +++ |
硬脂酸钠 | 50.0 | 54 | >30 | >10 | +++ |
甘油明胶 | 50.0 | 55 | >30 | >10 | +++ |
虫胶 | 50.0 | 52 | >30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
聚乙二醇1000 | 25.0 | 80 | <30 | >10 | + |
聚乙二醇2000 | 25.0 | 88 | <30 | >10 | ++ |
聚乙二醇4000 | 25.0 | 86 | <30 | <10 | ++ |
聚乙二醇6000 | 25.0 | 93 | <30 | <10 | +++ |
聚乙二醇8000 | 25.0 | 93 | <30 | <10 | +++ |
聚乙二醇9300 | 25.0 | 94 | <30 | >10 | ++ |
聚乙二醇10000 | 25.0 | 92 | <30 | <10 | +++ |
聚乙二醇20000 | 25.0 | 91 | <30 | <10 | ++ |
硬脂酸聚烃氧40酯 | 25.0 | 92 | <30 | <10 | ++ |
倍他环糊精 | 25.0 | 82 | <30 | >10 | ++ |
泊洛沙姆 | 25.0 | 89 | <30 | <10 | +++ |
羧甲基淀粉钠 | 25.0 | 80 | <30 | >10 | ++ |
十二烷基硫酸钠 | 25.0 | 77 | <30 | >10 | ++ |
硬脂酸 | 25.0 | 73 | >30 | >10 | +++ |
硬脂酸钠 | 25.0 | 72 | >30 | >10 | +++ |
甘油明胶 | 25.0 | 71 | >30 | >10 | +++ |
虫胶 | 25.0 | 72 | >30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
聚乙二醇1000 | 10.0 | 80 | <30 | >10 | + |
聚乙二醇2000 | 10.0 | 83 | <30 | >10 | ++ |
聚乙二醇4000 | 10.0 | 93 | <30 | <10 | +++ |
聚乙二醇6000 | 10.0 | 94 | <30 | <10 | +++ |
聚乙二醇8000 | 10.0 | 92 | <30 | <10 | +++ |
聚乙二醇9300 | 10.0 | 89 | <30 | >10 | +++ |
聚乙二醇10000 | 10.0 | 93 | <30 | <10 | +++ |
聚乙二醇20000 | 10.0 | 92 | <30 | <10 | +++ |
硬脂酸聚烃氧40酯 | 10.0 | 93 | <30 | <10 | ++ |
倍他环糊精 | 10.0 | 88 | <30 | <10 | ++ |
泊洛沙姆 | 10.0 | 92 | <30 | <10 | +++ |
羧甲基淀粉钠 | 10.0 | 86 | <30 | <10 | +++ |
十二烷基硫酸钠 | 10.0 | 83 | <30 | >10 | +++ |
硬脂酸 | 10.0 | 76 | >30 | >10 | +++ |
硬脂酸钠 | 10.0 | 77 | >30 | >10 | +++ |
甘油明胶 | 10.0 | 74 | >30 | >10 | +++ |
虫胶 | 10.0 | 73 | >30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶1 | 50 | 85 | <30 | <10 | ++ |
泊洛沙姆∶聚乙二醇=1∶1 | 50 | 86 | <30 | <10 | ++ |
羧甲基淀粉钠∶聚乙二醇=1∶1 | 50 | 81 | <30 | >10 | ++ |
倍他环糊精∶聚乙二醇=1∶1 | 50 | 78 | <30 | >10 | + |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶1 | 25 | 92 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶1 | 25 | 93 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶1 | 25 | 89 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶1 | 25 | 86 | <30 | >10 | ++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶1 | 10 | 92 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶1 | 10 | 92 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶1 | 10 | 90 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶1 | 10 | 84 | <30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶5 | 50 | 94 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶5 | 50 | 94 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶5 | 50 | 89 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶5 | 50 | 83 | <30 | >10 | ++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶5 | 25 | 94 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶5 | 25 | 95 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶5 | 25 | 92 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶5 | 25 | 89 | <30 | <10 | ++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶5 | 10 | 95 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶5 | 10 | 94 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶5 | 10 | 91 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶5 | 10 | 88 | <30 | <10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶10 | 50 | 91 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶10 | 50 | 91 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶10 | 50 | 89 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶10 | 50 | 82 | <30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶10 | 25 | 94 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶10 | 25 | 93 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶10 | 25 | 90 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶10 | 25 | 87 | <30 | <10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶10 | 10 | 94 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶10 | 10 | 93 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶10 | 10 | 91 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶10 | 10 | 90 | <30 | <10 | +++ |
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNB200510002878XA CN100542515C (zh) | 2005-01-28 | 2005-01-28 | 远志滴丸及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CNB200510002878XA CN100542515C (zh) | 2005-01-28 | 2005-01-28 | 远志滴丸及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN1679669A true CN1679669A (zh) | 2005-10-12 |
CN100542515C CN100542515C (zh) | 2009-09-23 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CNB200510002878XA Expired - Fee Related CN100542515C (zh) | 2005-01-28 | 2005-01-28 | 远志滴丸及其制备方法 |
Country Status (1)
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JP2017075136A (ja) * | 2015-06-08 | 2017-04-20 | ロート製薬株式会社 | 内服組成物 |
CN108524609A (zh) * | 2018-06-27 | 2018-09-14 | 贵州健兴药业有限公司 | 远志滴丸在制备用于治疗抗衰老的药物中的应用 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017075136A (ja) * | 2015-06-08 | 2017-04-20 | ロート製薬株式会社 | 内服組成物 |
JP2017075141A (ja) * | 2015-06-08 | 2017-04-20 | ロート製薬株式会社 | 内服組成物 |
CN108524609A (zh) * | 2018-06-27 | 2018-09-14 | 贵州健兴药业有限公司 | 远志滴丸在制备用于治疗抗衰老的药物中的应用 |
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