CN1627925A - Device that facilitates the handling of an animal cornea and, in particular, a human cornea - Google Patents
Device that facilitates the handling of an animal cornea and, in particular, a human cornea Download PDFInfo
- Publication number
- CN1627925A CN1627925A CNA038032457A CN03803245A CN1627925A CN 1627925 A CN1627925 A CN 1627925A CN A038032457 A CNA038032457 A CN A038032457A CN 03803245 A CN03803245 A CN 03803245A CN 1627925 A CN1627925 A CN 1627925A
- Authority
- CN
- China
- Prior art keywords
- cornea
- flask
- bearing
- handling
- executive component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004087 cornea Anatomy 0.000 title claims abstract description 35
- 241001465754 Metazoa Species 0.000 title abstract description 4
- 238000004321 preservation Methods 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 4
- 238000002054 transplantation Methods 0.000 claims description 4
- 230000007850 degeneration Effects 0.000 claims description 3
- 238000007431 microscopic evaluation Methods 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0095—Packages or dispensers for prostheses or other implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/142—Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Mechanical Engineering (AREA)
- Hematology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Prostheses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention relates to a device that facilitates the handling of animal corneas and, in particular, human corneas, with the purpose of optimising the preservation of corneal cells. According to the invention, the device is introduced into the different bottles and media used before a cornea graft. The inventive device minimises the contact surfaces during cornea preservation and prevents the direct handling thereof so that optimal cell quality is preserved before the graft. The device comprises a support (1) on which the cornea (11) is disposed, said support being fixed to a handling element (9) by means of clips (4).
Description
Technical field
The present invention relates to a kind ofly be convenient to operate the particularly device of human corneal of animal corneal, and seek before corneal transplantation, to optimize the preservation process of keratocyte.Before corneal transplantation, device of the present invention is inserted in the different flasks that contains liquid medium.
Background technology
With regard to human corneal, patient's corneal transplant is at first needed to take cornea on one's body away from a dead person.The cornea of taking away is inserted in the flask that contains a kind of " sampling " medium by the surgeon subsequently.Examine under a microscope subsequently, be inserted into again in second flask that contains impregnating fluid.At last, before the several hrs of transplant operation, one of reuse contains the 3rd flask of detumescence (deturgescent) medium, and this medium promptly is used for reducing swelling for cornea.
Usually, in the sampling flask, cornea is freely put into solution.In anticorrosion and detumescence flask, technology is to be suspended state ground to keep described cornea in the end of a silk thread, and described silk thread is pierced through with one single needle on the periphery that described cornea is fixed on cornea by usefulness.
This current technology has many shortcomings:
● operation is clumsy;
● described cornea must be used disinfectant or disposable apparatus;
● the danger of polluting or infecting is very big;
● the many places contact of the described flask walls that reclines can damage described keratocyte;
● described cornea the danger that described cornea adheres to described flask walls can occur in the stop of the bottom of described sampling flask, and, mean with rest on bottle at the bottom of degenerated cell contact.
Document EP 0262766 discloses a kind of cornea bracing or strutting arrangement on the flask stopper.This device need use special flask, and the standard flask is then inapplicable in this system.
Summary of the invention
An object of the present invention is to provide a kind of device, it can not duplicate the defective of prior art.
A special purpose of the present invention provides a kind of like this device, and its manufacturing, assembling, use are all very easy and with low cost, and it can use the flask that need not to reequip of standard.
Therefore, the invention provides a kind of device of being convenient to operate human corneal, can optimize keratocyte before the corneal transplantation in different flasks and the preservation in the medium, this device is characterized in that it comprises a bearing of placing cornea, is used for supporting described bearing with an executive component and also it can be extracted out from different flasks and medium.
Preferably, described device is totally independent of flask and/or flask plug.
Cornea preferably is maintained at one and reduces in the minimum space under situation about not being extruded.
Preferably the area that will contact with cornea minimizes.
Bearing is supported with a kind of ad hoc fashion by executive component, promptly cornea by support component for example jaw be located in top at the bottom of the flask, can deposit the cell of degeneration herein.
Thereby bearing preferably has at least one hole makes light directly pass through cornea in the microscopic analysis process.
Description of drawings
Other features and advantages of the present invention will be hereinafter become more cheer and bright in the mode of non-limiting example to the detailed description of a specific embodiment of the present invention by the reference accompanying drawing, wherein:
Fig. 1 a is the plane graph that constitutes the cornea bearing of one embodiment of the invention;
Fig. 1 b is the profile at A-A line place among Fig. 1 a;
Fig. 2 a is the plane graph of corresponding executive component;
Fig. 2 b is the profile at B-B line place among Fig. 2 a;
Fig. 2 c is the profile at X-X line place among Fig. 2 a;
Fig. 3 is the profile of assembly.
The specific embodiment
With reference to the accompanying drawings, in a preferred embodiment of the invention, this device comprises a bearing 1, and its profile is similar to the wheel with spoke 2, and spoke passes the bearing center.
Spoke 2 downward-sloping (position as shown in Fig. 1 b and Fig. 3) thus can make cornea 11 be positioned the center, thereby and its profile that preferably has a circle make the contact area minimum.
The height of bearing 1 is preferably limited by the height of transparent sterile board, and bearing is inserted in the microscopic analysis process in this transparent sterile board to avoid contacting cornea with cornea.The centre bore of bearing 1 can see through from microscopical light, thereby can observe directly cornea.
Operate bearing 1 with an executive component.Executive component 9 can be fixed on the described bearing 1 in a kind of dismountable mode.For example, available two fixing cards remain on bearing 1 on the executive component.Also can use other fixture.Executive component preferably includes jaw 5, and it can slide in the recess 6 of bearing 1, thereby can not hinder the operation bearing.
Preferably, jaw long enough and can remain on top at the bottom of the flask to bearing 1, cell that can some degenerations of deposition at the bottom of the flask.
The executive component 9 of apparatus of the present invention can also have the wheel 7 of a band spoke 8, thereby its profile with a circle can make the contact area minimum.Executive component can comprise a T type bar 10, and its length and width are fit to the standard flask, thereby makes this device can occupy described flask cervical region center.
Preferably, thereby apparatus of the present invention can be totally independent of flask and/or flask plug, so it can use in existing standard flask, and the standard flask does not have apparatus of the present invention usually.Then owing to having avoided using the flask of the specific transformation of the way to have more profitability.
This device is preferably made by plastic material, and can make by injecting on pressing mold in an independent molded operation.Also can use metal device, perhaps for example ceramic device of making of other material.
This device preferably can sterilize and be disposable.
Apparatus of the present invention are particularly suitable at transplant operation pre-treatment human corneal.
Like this, device of the present invention is convenient to operation, has reduced the contact area with cornea, and has eliminated the contact of finger.Especially, it is all right:
-with seat supports at a predetermined altitude;
-device is positioned the flask center; With
-bearing clean insertion or extraction from flask can be had no to damage the danger of cornea.
Although the present invention is described by an above-mentioned specific embodiment, obviously the present invention is not restricted to this embodiment.Therefore, the profile of " spoke-wheel " can be made amendment.Other remodeling also is conspicuous to those skilled in the art under the situation that does not exceed the scope of the present invention that is defined by the following claims.
Claims (6)
1. be convenient to operate the device of human corneal, can optimize keratocyte before corneal transplantation in different flasks and the preservation in the medium, described device is characterised in that, it comprises that one places the bearing (1) of described cornea (11), with an executive component (9)---and be used for supporting described bearing and also it can be taken out from different flasks and medium.
2. device as claimed in claim 1 is characterized in that, described device is totally independent of flask and/or flask plug.
3. device as claimed in claim 1 or 2 is characterized in that, under situation about not being extruded, described cornea is held and is contained in one and reduces in the minimum space.
4. as each described device in the above-mentioned claim, it is characterized in that the area that contacts with described cornea (11) is minimized.
5. as each described device in the above-mentioned claim, it is characterized in that, described bearing (1) is supported by described executive component (9), make described cornea (11) by described support component---for example jaw (5) is located in the top at the bottom of the described flask, can deposit the cell of degeneration at the bottom of described flask.
6. as each described device in the above-mentioned claim, it is characterized in that described bearing (1) has at least one hole (3), in the microscopic analysis process, described hole (3) allow light directly to lead to described cornea (11).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR02/01260 | 2002-02-04 | ||
| FR0201260A FR2835423B1 (en) | 2002-02-04 | 2002-02-04 | DEVICE FOR HANDLING HUMAN HUMAN BEFORE TRANSPLANT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1627925A true CN1627925A (en) | 2005-06-15 |
Family
ID=27619848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA038032457A Pending CN1627925A (en) | 2002-02-04 | 2003-02-04 | Device that facilitates the handling of an animal cornea and, in particular, a human cornea |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20050149055A1 (en) |
| EP (1) | EP1474076A1 (en) |
| JP (1) | JP2005516671A (en) |
| CN (1) | CN1627925A (en) |
| AU (1) | AU2003222878A1 (en) |
| BR (1) | BR0307445A (en) |
| FR (1) | FR2835423B1 (en) |
| RU (1) | RU2296545C2 (en) |
| WO (1) | WO2003065937A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105286778A (en) * | 2015-09-30 | 2016-02-03 | 深圳艾尼尔角膜工程有限公司 | Cornea location system and location method |
| CN105342749A (en) * | 2015-09-30 | 2016-02-24 | 深圳艾尼尔角膜工程有限公司 | System and method for automatically positioning cornea |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1634497A1 (en) * | 2004-09-14 | 2006-03-15 | Medical Technology Transfer Holding B.V. | Suspension device for donor corneal tissue storage |
| US7662611B2 (en) | 2004-10-26 | 2010-02-16 | Cleo Cosmetic And Pharmaceutical Company, Llc | Apparatus and method for in vitro storage of a cornea |
| US20100120013A1 (en) * | 2008-11-07 | 2010-05-13 | Mb Research Laboratories, Inc. | Procedure for long term corneal culture |
| US11154052B2 (en) | 2018-09-14 | 2021-10-26 | University Of Miami | Dual-chamber vial for corneal graft preservation |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3139097A (en) * | 1962-11-28 | 1964-06-30 | Barnes Hind International Inc | Cleansing device for contact lenses |
| US3314533A (en) * | 1965-11-15 | 1967-04-18 | Kopfle John Arnold | Lens containing and dispensing device |
| US4423809A (en) * | 1982-02-05 | 1984-01-03 | Staar Surgical Company, Inc. | Packaging system for intraocular lens structures |
| US4824066A (en) * | 1983-04-11 | 1989-04-25 | Smith S Gregory | Apparatus for aiding in the storing and preserving of donor corneas |
| US5019084A (en) * | 1986-08-06 | 1991-05-28 | Minnesota Mining And Manufacturing Company | Corneal holder |
| US4981657A (en) * | 1988-09-09 | 1991-01-01 | Ryder International Corporation | Contact lens case with raised, protective ribs |
| US5817075A (en) * | 1989-08-14 | 1998-10-06 | Photogenesis, Inc. | Method for preparation and transplantation of planar implants and surgical instrument therefor |
| US5167323A (en) * | 1990-08-09 | 1992-12-01 | Tomei Sangyo Co., Ltd. | Lens treating device for treating contact lens |
| US5407241A (en) * | 1994-07-21 | 1995-04-18 | Harrison; Kenneth | Contact lens applicator |
| US6256089B1 (en) * | 1999-12-16 | 2001-07-03 | Eyetech Vision, Inc. | Optical donor tissue cell |
| US6543610B1 (en) * | 2000-09-12 | 2003-04-08 | Alok Nigam | System for packaging and handling an implant and method of use |
-
2002
- 2002-02-04 FR FR0201260A patent/FR2835423B1/en not_active Expired - Fee Related
-
2003
- 2003-02-04 BR BR0307445-5A patent/BR0307445A/en not_active IP Right Cessation
- 2003-02-04 JP JP2003565367A patent/JP2005516671A/en active Pending
- 2003-02-04 US US10/503,474 patent/US20050149055A1/en not_active Abandoned
- 2003-02-04 AU AU2003222878A patent/AU2003222878A1/en not_active Abandoned
- 2003-02-04 RU RU2004126694/14A patent/RU2296545C2/en not_active IP Right Cessation
- 2003-02-04 WO PCT/FR2003/000339 patent/WO2003065937A1/en active Application Filing
- 2003-02-04 CN CNA038032457A patent/CN1627925A/en active Pending
- 2003-02-04 EP EP03718833A patent/EP1474076A1/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105286778A (en) * | 2015-09-30 | 2016-02-03 | 深圳艾尼尔角膜工程有限公司 | Cornea location system and location method |
| CN105342749A (en) * | 2015-09-30 | 2016-02-24 | 深圳艾尼尔角膜工程有限公司 | System and method for automatically positioning cornea |
| CN105286778B (en) * | 2015-09-30 | 2017-02-22 | 深圳艾尼尔角膜工程有限公司 | Cornea location system and location method |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2835423B1 (en) | 2004-11-05 |
| WO2003065937A1 (en) | 2003-08-14 |
| EP1474076A1 (en) | 2004-11-10 |
| AU2003222878A1 (en) | 2003-09-02 |
| FR2835423A1 (en) | 2003-08-08 |
| US20050149055A1 (en) | 2005-07-07 |
| RU2004126694A (en) | 2005-06-27 |
| BR0307445A (en) | 2004-12-28 |
| JP2005516671A (en) | 2005-06-09 |
| RU2296545C2 (en) | 2007-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| AD01 | Patent right deemed abandoned | ||
| C20 | Patent right or utility model deemed to be abandoned or is abandoned |