CN1616063A - Dementholized mint oil dripping pill - Google Patents
Dementholized mint oil dripping pill Download PDFInfo
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- CN1616063A CN1616063A CN 200410080513 CN200410080513A CN1616063A CN 1616063 A CN1616063 A CN 1616063A CN 200410080513 CN200410080513 CN 200410080513 CN 200410080513 A CN200410080513 A CN 200410080513A CN 1616063 A CN1616063 A CN 1616063A
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Abstract
The present invention discloses a kind of medicine composition for treating calculous cholecystitis, and is especially one orally taken medicine composition preparation with dementholized mint oil as active component. The dementholized mint oil dripping pill of the present invention has high bioavailability, fast medicine release, quick acting, less toxic side effect, pollution-free production process and low cost. The dementholized mint oil dripping pill of the present invention has dementholized mint oil as active component, which is mixed with non-ionic surfactant as the matrix to prepare the dementholized mint oil dripping pill.
Description
Technical field
The present invention relates to a kind of chronic venous insufficiency that is used for, chronic cholecystitis and the pent-up of cholelithiasis liver and gall, damp and hot stomach treatment of diseases medicine such as stagnate particularly is the drug composition oral preparation of active constituents of medicine with the Oleum menthae.
Background technology
In China, cholelithiasis has become commonly encountered diseases, frequently-occurring disease, thereby has caused people's extensive concern.According to statistics, the eighties, cholelithiasis accounted for 52.8% of national cholelithiasis, to the nineties, had risen to 79.9%.Cholelithiasis has become commonly encountered diseases, frequently-occurring disease, is perplexing huge numbers of families
[1]Cholelithiasis and chronic cholecystitis often exist simultaneously, but and both normal reciprocal causations.According to statistics, the chronic cholecystitis patient is associated with cholelithiasis more than 95%.Cholelithiasis worldwide all is a kind of common, multiple disease, and sickness rate can reach 6.5% among the over-65s crowd, and the women is particularly multiple.In recent years, along with growth in the living standard, the sickness rate of China's cholelithiasis is also increasing year by year, and the big city is more obvious.
Show according to interrelated data, at present for the disease of cholelithiasis and so on mainly still based on the way of operative treatment, but quite a few people is also arranged owing to various reasons, he is unwilling or can not be treated surgically and the lithagogue treatment taking to guard.
Since the fifties in last century, joint efforts through clinical Chinese and western medicine doctor, tentatively set up comparatively complete cholelithiasis Chinese and western medicine Comprehensive Treatment system, it comprises rubble, calculus, the lithodialysis that keeps gallbladder and gets stone and cholecystectomy, i.e. " broken row is molten to cut " treatment system.Facts have proved that the whole bag of tricks in this system all has corresponding indication, also exist pros and cons separately, have only to correctly select to use and in addition scientifically development improve, just can make it ripe, improve the therapeutic effect near at a specified future date of cholelithiasis
[2]
1. Oleum menthae is that the report that is used for the treatment of calcareous cholecystitis has just been arranged in recent years, contains effective ingredient such as limonene in the Oleum menthae, the cholesteric layer in the solubilized combination calculus.The reaction rate of this liquid one solid heterogeneous reaction is relevant with the height of surface of solids molecular energy, and molecular energy is high more, and the effective collision number of times is many more in the unit interval, and reaction rate is fast more.Be lower than the molecular energy of other surface because of the molecular energy of surface of solids corner angle and boundary.Cause corner angle, the dissolved speed of boundary cholesterol to be lower than the dissolved speed of surperficial cholesterol, the result makes the residual stone corner angle of dissolving clearly demarcated, and the surface is spill
[3]
2. Oleum menthae is the volatile oil of labiate Herba Menthae, mainly contains L-Mentholum (being menthol) 77%～87% in the oil, is L-menthone about 8%～12% and Herba Menthae esters secondly.Menthol or menthone 260 μ mol/kg (about 40mg/kg) give rat oral, and stronger choleretic effect is arranged, and to behind menthol 3h～4h, bile eliminating amount increases by 4 times approximately, and effect subsequently weakens; The menthone effect is similar, but more lasting, and behind the administration 5h, bile eliminating amount increases by 50%～100%.Acetone dry extract of Herba Menthae or 50% methanol dry extract (effective ingredient is a menthol) 50mg/kg duodenal administration has significant choleretic effect to anesthetized rat, 0.5h～1h after the administration, and effect reaches the peak, and bile eliminating amount is about 2～4 times of matched group
[4]
At present be that the oral drugs that main component is used for the treatment of cholelithiasis have DANSHU JIAONANG with the Oleum menthae, DANSHU JIAONANG is a kind of capsule that the theory of Chinese medical science according to depressed liver-energy dispersing and function of gallbladder promoting, regulating QI to relieve pain develops, form by the isolating Mentholum of natural plants (menthol), menthone (menthone) etc., clinically cholecystitis, cholelithiasis are had curative effect preferably
[5]The DANSHU JIAONANG of recording for national drug tentative standard WS-10700 (ZD-0770)-No. 2002 has following explanation:
Prescription: Oleum menthae 100g, starch 350g makes 1000;
Function cures mainly: liver-smoothing, qi-regulating, function of gallbladder promoting.Be mainly used in chronic venous insufficiency, chronic cholecystitis and the pent-up of cholelithiasis liver and gall, damp and hot stomach stagnates and demonstrate,proves.
Yet, owing to reasons such as technologies of preparing, exist all after the oral formulations of most drug is taken that dissolve scattered time limit is long, dissolution is low, absorption is relatively poor, problem such as liver sausage first pass effect and bioavailability are lower, thereby influence the performance of drug effect, also directly affect therapeutic effect.
In addition, conventional dosage forms such as capsule can produce bigger dust pollution in preparation process, can staff's health be worked the mischief to a certain extent, also can cause certain pollution to environment simultaneously.
Moreover the production technology of drop pill is simple, and production cost is lower, usually at about 50% of capsule, patient's drug cost is reduced according to measuring and calculating greatly, helps improving the ability of seeking medical advice of extensive patients, also helps improving the general health level of society.
As seen drop pill is as a kind of new pharmaceutical preparation, the many disadvantages that can overcome conventional oral formulations to a great extent and had.It is investigated and the domestic manufacturer that the plain drop pill of any Oleum menthae that formally gets the Green Light is not also arranged so far also find no any report that closes the Dementholized mint oil dripping pill production technology.
Summary of the invention
Purpose of the present invention, be to replenish the existing deficiency that is used for the treatment of gallbladder disease pharmaceutical preparation, provide a kind of bioavailability height to extensive patients and medical personnel, release fast, quick produce effects, toxic and side effects is littler, and produce pollution-free, the drug composition oral preparation Dementholized mint oil dripping pill that production cost is lower.
Of the present invention and Dementholized mint oil dripping pill be active constituents of medicine with the Oleum menthae, mix mutually, be prepared from non-ionic surface active agent as substrate.Be prepared by the following technical solutions, can obtain Dementholized mint oil dripping pill involved in the present invention:
[prescription]
1. Oleum menthae---adopt commercially available finished product Oleum menthae (as the product of the West Lake, Hangzhou essence and flavoring agent company limited), its active constituents of medicine mainly contains L-Mentholum (being menthol), L-menthone, and Herba Menthae esters formation, its discrimination method sees the related standards of manufacturer for details;
2. substrate---Polyethylene Glycol
2000～20000, pharmaceutically suitable carrier such as stearic acid, sodium stearate, glycerin gelatine, polyoxyethylene stearate 40 esters, Lac, polyoxyethylene monostearate, polyethers, carboxymethyl starch sodium, sodium lauryl sulphate one or more mixture wherein;
3. proportioning (with g or kg is unit, according to the weight portion meter), Oleum menthae: substrate=1: 1～1: 5.
[preparation method]
1. according to the given ratio of prescription, accurately take by weighing each medicine material and substrate, the substrate that is taken by weighing is placed heating while stirring in the heating container, treat complete fusion, add Oleum menthae again and stir, obtain containing the pharmaceutical composition mixed liquor of Oleum menthae and substrate;
2. adopt homemade or general drop pill machine (as the TZDW-1 type drop pill machine of Changzheng Tianmin High Science ﹠ Technology Co., Ltd., Beijing's production), and the temperature control system of adjustment drop pill machine, make the water dropper temperature heating of drop pill machine and remain on (50～90) ℃, the temperature cooling of condensing agent also remains on (40～-5) ℃;
3. treating that the temperature of condensing agent in dropping-pill machine head and the condensation column is stable respectively is in above the 2nd step during desired state of temperature, the pharmaceutical composition mixed liquor that will contain Oleum menthae and substrate places in the water dropper storage vat of drop pill machine, splashes in the condensing agent by water dropper with suitable speed.
Condensing agent can be any one in liquid paraffin, methyl-silicone oil, the vegetable oil;
4. will shrink the drop pill taking-up of molding by the outlet of drop pill machine, remove the surface condensation agent, be drying to obtain.
Beneficial effect
At present be that the oral drugs that main component is used for the treatment of cholelithiasis have DANSHU JIAONANG with the Oleum menthae, DANSHU JIAONANG is a kind of capsule that the theory of Chinese medical science according to depressed liver-energy dispersing and function of gallbladder promoting, regulating QI to relieve pain develops, form by the isolating Mentholum of natural plants (menthol), menthone (menthone) etc., clinically cholecystitis, cholelithiasis are had curative effect preferably
[5]The DANSHU JIAONANG of recording for national drug tentative standard WS-10700 (ZD-0770)-No. 2002 has following explanation:
Prescription: Oleum menthae 100g, starch 350g makes 1000;
Function cures mainly: liver-smoothing, qi-regulating, function of gallbladder promoting.Be mainly used in chronic venous insufficiency, chronic cholecystitis and the pent-up of cholelithiasis liver and gall, damp and hot stomach stagnates and demonstrate,proves.
Yet, owing to reasons such as technologies of preparing, exist all after the oral formulations of most drug is taken that dissolve scattered time limit is long, dissolution is low, absorption is relatively poor, problem such as liver sausage first pass effect and bioavailability are lower, thereby influence the performance of drug effect, also directly affect therapeutic effect.
In addition, conventional dosage forms such as capsule can produce bigger dust pollution in preparation process, can staff's health be worked the mischief to a certain extent, also can cause certain pollution to environment simultaneously.
Moreover the production technology of drop pill is simple, and production cost is lower, usually at about 50% of capsule, patient's drug cost is reduced according to measuring and calculating greatly, helps improving the ability of seeking medical advice of extensive patients, also helps improving the general health level of society.
Dementholized mint oil dripping pill involved in the present invention is compared with its capsule, has following beneficial effect:
1. Dementholized mint oil dripping pill involved in the present invention; utilize surfactant to be substrate; make solid dispersion with the Oleum menthae that contains active constituents of medicine; making medicine be molecule, colloid or microcrystalline state is scattered in the substrate; the total surface area of medicine increases, and substrate is hydrophilic, and medicine is had wetting action; can make that medicine is rapidly molten to loose into microgranule or solution, thereby make the dissolving of medicine and absorb and accelerate.Thereby improved bioavailability, brought into play efficient, quick-acting effects etc.
Compare with the administering mode of traditional oral formulations, exist essential distinction.Drop pill with the solid dispersion technology preparation can adopt oral and sublingual administration, and effective ingredient is fully contacted with mucomembranous surface, absorbs by mucomembranous epithelial cell, directly enters blood circulation.Owing to directly enter blood circulation without gastrointestinal tract and liver, avoided first pass effect effectively, also avoided gastrointestinal irritation, thereby it is rapid to have an onset, bioavailability height, characteristics such as side effect is little, and medication is convenient.
2. Dementholized mint oil dripping pill involved in the present invention contacts promptly with saliva and to dissolve rapidly, and is absorbed by oral mucosa, and is not only rapid-action, and the influence of not taken food, and promptly all can containing take after meal ante cibum.
3. production technology, the equipment of preparation drop pill are simple, easy to operate, the automaticity height, and labor intensity is low, the production efficiency height.Workshop does not have dust simultaneously, helps labor protection and environmental protection yet.
The preparation drop pill need adopt high-tech means and equipment, and active constituents of medicine is uniformly dispersed in substrate, and dosage is accurate, and the ball method of double differences is different little than tablet, and production cost is with about 50% of kind tablet.
4. Dementholized mint oil dripping pill involved in the present invention mixes active constituents of medicine mutually with molten matrix, splashes in the not miscible condensed fluid to make.Therefore, the stability of drug height, not facile hydrolysis, oxidation, and the operation be under liquid state, to carry out, no dust pollution is not subject to the influence of crystal formation, thereby has guaranteed the quality of medicine, has increased stability.
In sum, make Dementholized mint oil dripping pill involved in the present invention have the advantage of triple effect (quick-acting, efficient, long-acting), three little (taking dose is little, toxicity is little, side effect little), five convenience (convenient for production, store convenience, convenient transportation, easy to carry, easy to use).
The specific embodiment
Now with regard to the preparation method of Dementholized mint oil dripping pill of the present invention, test to be further described with three groups of specific embodiments.
[prescription]
1. Oleum menthae---adopt the finished product Oleum menthae of the West Lake, Hangzhou essence and flavoring agent company limited;
2. substrate---Polyethylene Glycol
2000,4000,6000,8000,10000,2000, pharmaceutically suitable carrier such as stearic acid, sodium stearate, glycerin gelatine, polyoxyethylene stearate 40 esters, Lac, polyoxyethylene monostearate, polyethers, carboxymethyl starch sodium, sodium lauryl sulphate;
3. proportioning (with g or kg is unit, according to the weight portion meter), Oleum menthae: substrate=1: (1～5);
[result of the test]
Test 1: constituting the mass discrepancy of pharmaceutical composition when 1: 1 the proportioning in order to observe Oleum menthae and different substrates, is active pharmaceutical ingredient with the Oleum menthae, respectively with Polyethylene Glycol
2000, Polyethylene Glycol
4000, Polyethylene Glycol
6000, Polyethylene Glycol
8000, Polyethylene Glycol
10000, Polyethylene Glycol
20000, pharmaceutically suitable carrier such as stearic acid, sodium stearate, polyoxyethylene stearate 40 esters, glycerin gelatine, Lac, polyoxyethylene monostearate, polyethers, carboxymethyl starch sodium, sodium lauryl sulphate is as substrate, the ratio of Oleum menthae and each substrate is 1: 1.Adopt homemade drop pill machine, be prepared, can obtain the experiment of 15 pharmaceutical compositions that Oleum menthae and different substrates constituted, and obtain 15 groups of different experimental results and see Table 1 according to the step of stipulating in the preparation method.
Test 2: constituting the mass discrepancy of pharmaceutical composition when 1: 2 the proportioning in order to observe Oleum menthae and different substrates, is active pharmaceutical ingredient with the Oleum menthae, respectively with Polyethylene Glycol
2000, Polyethylene Glycol
4000, Polyethylene Glycol
6000, Polyethylene Glycol
8000, Polyethylene Glycol
10000, Polyethylene Glycol
20000, pharmaceutically suitable carrier such as stearic acid, sodium stearate, polyoxyethylene stearate 40 esters, glycerin gelatine, Lac, polyoxyethylene monostearate, polyethers, carboxymethyl starch sodium, sodium lauryl sulphate is as substrate, the ratio of Oleum menthae and each substrate is 1: 1.Adopt homemade drop pill machine, be prepared, can obtain the experiment of 15 pharmaceutical compositions that Oleum menthae and different substrates constituted, and obtain 15 groups of different experimental results and see Table 2 according to the step of stipulating in the preparation method.
Test 3: constituting the mass discrepancy of pharmaceutical composition when 1: 5 the proportioning in order to observe Oleum menthae and different substrates, is active pharmaceutical ingredient with the Oleum menthae, respectively with Polyethylene Glycol
2000, Polyethylene Glycol
4000, Polyethylene Glycol
6000, Polyethylene Glycol
8000, Polyethylene Glycol
10000, Polyethylene Glycol
20000, pharmaceutically suitable carrier such as stearic acid, sodium stearate, polyoxyethylene stearate 40 esters, glycerin gelatine, Lac, polyoxyethylene monostearate, polyethers, carboxymethyl starch sodium, sodium lauryl sulphate is as substrate, the ratio of Oleum menthae and each substrate is 1: 5.Adopt homemade drop pill machine, be prepared, can obtain the experiment of 15 pharmaceutical compositions that Oleum menthae and different substrates constituted, and obtain 15 groups of different experimental results and see Table 3 according to the step of stipulating in the preparation method.
The partial reference data is as follows:
1. the bright life of king. the treatment of cholelithiasis will standardize. Chinese general surgery magazine the 15th the 10th phase of volume of October in 2000;
2. the Zhu Pei front yard is opened quiet. the therapy of combining Chinese and Western medicine of cholecystitis, cholelithiasis. and the 14th volume the 1st phase ([middle figure classification number] R575.6, [Document code] C, [article numbering] 1007-1954 (2002) 01-0002-02) of liver and gall pancreas surgical magazine;
3. Sesbania cannabina (Retz.) Pers. is flat, Dong Hongwei. the lithodialysis research of mixed type calculus in pure Oleum menthae. and Mountain Western Medicine S University's journal 2000,31 (1);
4. Chen Guangliang, She Yubao, Li Dongmei. Chinese the 7th the 2nd phase of volume of Chinese medicine information magazine .2000 is P.33-34;
5. Chen Guangliang, Yao Daoyun, Wang Yuanjin, She Yubao, model peak. the DANSHU JIAONANG Expermental research on main pharmacodynamics. Chinese Chinese medicine science and technology the 8th 2 phases of volume of calendar year 2001
The group practices of table 1 Oleum menthae and different substrates (1: 1)
| The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
| Polyethylene Glycol 2000 | ??50.0 | 68 | ??＜30 | ??＞10 | + |
| Polyethylene Glycol 4000 | ??50.0 | 86 | ??＜30 | ??＞10 | + |
| Polyethylene Glycol 6000 | ??50.0 | 89 | ??＜30 | ??＞10 | ++ |
| Polyethylene Glycol 8000 | ??50.0 | 89 | ??＜30 | ??＞10 | ++ |
| Polyethylene Glycol 10000 | ??50.0 | 90 | ??＜30 | ??＞10 | ++ |
| Polyethylene Glycol 20000 | ??50.0 | 89 | ??＜30 | ??＞10 | ++ |
| Stearic acid | ??50.0 | 62 | ??＜30 | ??＞10 | |
| Sodium stearate | ??50.0 | 72 | ??＜30 | ??＞10 | |
| Glycerin gelatine | ??50.0 | 56 | ??＜30 | ??＞10 | |
| Polyoxyethylene stearate 40 esters | ??50.0 | 83 | ??＜30 | ??＞10 | ++ |
| Lac | ??50.0 | 33 | ??＜30 | ??＞10 | |
| The polyoxyethylene monostearate | ??50.0 | 77 | ??＜30 | ??＞10 | + |
| Polyethers | ??50.0 | 73 | ??＜30 | ??＞10 | ++ |
| Carboxymethyl starch sodium | ??50.0 | 73 | ??＜30 | ??＞10 | ++ |
| Sodium lauryl sulphate | ??50.0 | 69 | ??＜30 | ??＞10 | + |
Result by table 1 can see: when Oleum menthae: during substrate=1: 1, the rounding rate, the ball method of double differences is different and index such as hardness is all undesirable, and dissolve scattered time limit institute is influenced not obvious.
The group practices of table 2 Oleum menthae and different substrates (1: 2)
| The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
| Polyethylene Glycol 2000 | ??33.3 | ??70 | ??＜30 | ??＞10 | + |
| Polyethylene Glycol 4000 | ??33.3 | ??91 | ??＜30 | ??＜10 | ++ |
| Polyethylene Glycol 6000 | ??33.3 | ??93 | ??＜30 | ??＜10 | +++ |
| Polyethylene Glycol 8000 | ??33.3 | ??93 | ??＜30 | ??＜10 | +++ |
| Polyethylene Glycol 10000 | ??33.3 | ??96 | ??＜30 | ??＜10 | +++ |
| Polyethylene Glycol 20000 | ??33.3 | ??95 | ??＜30 | ??＜10 | +++ |
| Stearic acid | ??33.3 | ??71 | ??＜30 | ??＞10 | + |
| Sodium stearate | ??33.3 | ??75 | ??＜30 | ??＞10 | + |
| Glycerin gelatine | ??33.3 | ??65 | ??＜30 | ??＞10 | + |
| Polyoxyethylene stearate 40 esters | ??33.3 | ??90 | ??＜30 | ??＜10 | +++ |
| Lac | ??33.3 | ??66 | ??＜30 | ??＞10 | + |
| The polyoxyethylene monostearate | ??33.3 | ??75 | ??＜30 | ??＞10 | + |
| Polyethers | ??33.3 | ??92 | ??＜30 | ??＜10 | +++ |
| Carboxymethyl starch sodium | ??33.3 | ??87 | ??＜30 | ??＜10 | ++ |
| Sodium lauryl sulphate | ??33.3 | ??71 | ??＜30 | ??＞10 | + |
Result by table 2 can see: when Oleum menthae: during substrate=1: 2, part rounding rate, the ball method of double differences is different and index such as hardness is tending towards desirable, and dissolve scattered time limit institute is influenced not obvious.
The group practices of table 3 Oleum menthae and different substrates (1: 5)
| The substrate title | Effective ingredient (%) | Rounding rate (%) | Dissolve scattered time limit (minute) | The ball method of double differences different (%) | Hardness |
| Polyethylene Glycol 2000 | ??16.7 | ??78 | ??＜30 | ??＞10 | + |
| Polyethylene Glycol 4000 | ??16.7 | ??92 | ??＜30 | ??＜10 | ++ |
| Polyethylene Glycol 6000 | ??16.7 | ??93 | ??＜30 | ??＜10 | +++ |
| Polyethylene Glycol 8000 | ??16.7 | ??86 | ??＜30 | ??＜10 | +++ |
| Polyethylene Glycol 10000 | ??16.7 | ??82 | ??＞30 | ??＜10 | +++ |
| Polyethylene Glycol 20000 | ??16.7 | ??82 | ??＞30 | ??＜10 | +++ |
| Stearic acid | ??16.7 | ??78 | ??＜30 | ??＞10 | ++ |
| Sodium stearate | ??16.7 | ??69 | ??＞30 | ??＞10 | ++ |
| Glycerin gelatine | ??16.7 | ??63 | ??＞30 | ??＞10 | ++ |
| Polyoxyethylene stearate 40 esters | ??16.7 | ??91 | ??＜30 | ??＜10 | +++ |
| Lac | ??16.7 | ??63 | ??＞30 | ??＞10 | + |
| The polyoxyethylene monostearate | ??16.7 | ??82 | ??＜30 | ??＞10 | + |
| Polyethers | ??16.7 | ??92 | ??＜30 | ??＜10 | +++ |
| Carboxymethyl starch sodium | ??16.7 | ??87 | ??＜30 | ??＜10 | +++ |
| Sodium lauryl sulphate | ??16.7 | ??82 | ??＜30 | ??＞10 | ++ |
Result by table 3 can see: when Oleum menthae: during substrate=1: 5, most of rounding rate, the ball method of double differences is different and index such as hardness is tending towards desirable, and the part dissolve scattered time limit is under some influence.
(annotate: the hardness method for expressing in the subordinate list, adopt drop pill is placed on the glass plate, press...with one's finger it, observe its metamorphosis."+" expression flicking promptly is out of shape, " ++ " expression distortion of firmly pressing, and " +++" expression is indeformable by it.)
Claims (5)
1. a Dementholized mint oil dripping pill that is used for the treatment of calculus class cholecystitis is made up of Oleum menthae that contains active constituents of medicine and substrate, wherein:
1.1 Oleum menthae---commercially available finished product Oleum menthae, its active constituents of medicine mainly contains the L-Mentholum, claims menthol again, the L-menthone, and the Herba Menthae esters etc.;
1.2 substrate---Polyethylene Glycol
2000～20000, pharmaceutically suitable carrier such as stearic acid, sodium stearate, glycerin gelatine, polyoxyethylene stearate 40 esters, Lac, polyoxyethylene monostearate, polyethers, carboxymethyl starch sodium, sodium lauryl sulphate one or more mixture wherein;
1.3 proportioning---Oleum menthae: substrate=1: 1～1: 5.
2. Dementholized mint oil dripping pill as claimed in claim 1 is characterized in that: described substrate is Polyethylene Glycol
2000, Polyethylene Glycol
4000, Polyethylene Glycol
6000, Polyethylene Glycol
8000, Polyethylene Glycol
10000, Polyethylene Glycol
20000
3. Dementholized mint oil dripping pill as claimed in claim 1 is characterized in that: described substrate is polyoxyethylene stearate 40 esters, carboxymethyl starch sodium, sodium lauryl sulphate.
4. Dementholized mint oil dripping pill as claimed in claim 1 is characterized in that: described substrate is polyoxyethylene stearate 40 esters, carboxymethyl starch sodium, sodium lauryl sulphate, Polyethylene Glycol
4000, Polyethylene Glycol
6000, Polyethylene Glycol
8000, Polyethylene Glycol
10000, Polyethylene Glycol
20000In two or more mixture in pharmaceutically suitable carrier.
5. as the described any Dementholized mint oil dripping pill of claim 1～4, it is characterized in that: the ratio of described Oleum menthae and substrate is 1: 1～1: 3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100805134A CN1325047C (en) | 2004-09-30 | 2004-09-30 | Dementholized mint oil dripping pill |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100805134A CN1325047C (en) | 2004-09-30 | 2004-09-30 | Dementholized mint oil dripping pill |
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| Publication Number | Publication Date |
|---|---|
| CN1616063A true CN1616063A (en) | 2005-05-18 |
| CN1325047C CN1325047C (en) | 2007-07-11 |
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|---|---|---|---|
| CNB2004100805134A Expired - Fee Related CN1325047C (en) | 2004-09-30 | 2004-09-30 | Dementholized mint oil dripping pill |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1309379C (en) * | 2005-07-29 | 2007-04-11 | 北京科信必成医药科技发展有限公司 | Asari dripping pills and its preparation process |
| CN109329943A (en) * | 2018-11-12 | 2019-02-15 | 汉中市汉鲵食品加工有限公司 | A kind of sustained-release dropping pill of the oil containing giant salamander |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168009A (en) * | 2015-09-30 | 2015-12-23 | 安徽丰乐香料有限责任公司 | Water-soluble dropping pills containing compound cooling agent and preparation method of dropping pills |
| CN109925340A (en) * | 2019-04-12 | 2019-06-25 | 中国医科大学附属第一医院 | Molten cholelith hydraulic fluid port formulation and its preparation process |
-
2004
- 2004-09-30 CN CNB2004100805134A patent/CN1325047C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1309379C (en) * | 2005-07-29 | 2007-04-11 | 北京科信必成医药科技发展有限公司 | Asari dripping pills and its preparation process |
| CN109329943A (en) * | 2018-11-12 | 2019-02-15 | 汉中市汉鲵食品加工有限公司 | A kind of sustained-release dropping pill of the oil containing giant salamander |
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| Publication number | Publication date |
|---|---|
| CN1325047C (en) | 2007-07-11 |
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