CN1616010A - Medicine for treating diabetes and its preparing method - Google Patents
Medicine for treating diabetes and its preparing method Download PDFInfo
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- CN1616010A CN1616010A CN 200410073887 CN200410073887A CN1616010A CN 1616010 A CN1616010 A CN 1616010A CN 200410073887 CN200410073887 CN 200410073887 CN 200410073887 A CN200410073887 A CN 200410073887A CN 1616010 A CN1616010 A CN 1616010A
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Abstract
The medicine for treating diabetes consists of effective medicine components and pharmaceutically acceptable carrier. The effective medicine components includes kudzu vine root, rehmannia root, astragalus root, trichosanthes root, corn stigma, schisandra, Chinese yam and glibenclamide. It has the functions of nourishing kidney-Yin, benefiting vital energy and promoting the secretion of saliva, and is used in treating diabetes of deficiency in both vital energy and Yin. The preparation process is also disclosed.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of diabetes, the invention still further relates to the preparation method of this medicine.
Background technology
Diabetes are the higher a kind of diseases of modern society's sickness rate, show as polydipsia more, polyuria, and polyphagia is become thin, fatigue and lack of strength, the difference of sleeping lumbago, symptoms such as glucose in urine and blood sugar increasing.At present the medicine of treatment diabetes has three classes: a class is a pure Chinese medicinal preparation, a class be in, the Western medicine mixture is as adding the preparation of Chinese medicine with glibenclamide; Also having a class is exactly pure Western medicine such as insulin substitution therapy.The patent application of finding the pure Chinese medicinal preparation of treatment diabetes by retrieval has: 03128106,02127924,021338523,02109573,02104038,02107203,02103665.In these patents, be that natural Chinese medicines such as Radix Puerariae, Radix Trichosanthis, Rhizoma Atractylodis, Radix Scrophulariae, Radix Astragali, Rhizoma Dioscoreae, Gypsum Fibrosum, Cortex Cinnamomi, RADIX ACONITILATERALIS PREPARATA, Ramulus Euonymi, Eupolyphaga Seu Steleophaga, Herba Taxilli, Bombyx bombycis, stir-baked SQUAMA MANITIS, Hirudo, Sanguis Draxonis, Rhizoma Smilacis Chinensis, the Rhizoma Anemarrhenae, Herb Gynostemmae Pentaphylli, the Radix Rehmanniae, Radix Ophiopogonis, Radix Paeoniae Rubra, Cortex Lycii, Radix et Rhizoma Rhei (processed) are raw material with the prescription of patent application 02107203.Flavour of a drug are various, and uncertain therapeutic efficacy is cut.The patent application of the second class Chinese-western medicine preparation is respectively: 97107209,97107198,01127922,96115929.Patent application 96115929 prescriptions are Radix Ginseng, Radix Rehmanniae, the Rhizoma Anemarrhenae, pollen, glibenclamide, N-phenformin, and Radix Puerariae, Fructus Schisandrae Chinensis, Rhizoma Coptidis, also need add Rhizoma Chuanxiong, Flos Carthami, Radix Salviae Miltiorrhizae, white wood Chinese tallowtree root bark and Radix Paeoniae Rubra, the Radix Astragali, aspirin, Tmp for complication.Manufacture method of the present invention comprises that Chinese medicine mixing, decoction, concentrate drying, Chinese medicine are pulverized, autoclaving, mixes with Western medicine after pulverizing.Chen Gang, Ni Yiping and Lai Xiaoming have delivered the article of " diabetes pill is treated the clinical research of deficiency of both QI and YIN disease type 2 diabetes mellitus " in the 14th the 2nd phase of volume of " new Chinese medicine and clinical pharmacology " March in 2003, and wherein disclosing the diabetes pill composition is Radix Puerariae, Radix Rehmanniae, the Radix Astragali, Radix Trichosanthis, Stigma Maydis, Fructus Schisandrae Chinensis, Rhizoma Dioscoreae and glibenclamide.Function is nourishing kidney-YIN, supplementing QI for promoting the production of body fluid with curing mainly.Be used for polydipsia, polyuria, polyphagia is become thin, fatigue and lack of strength, the difference of sleeping lumbago, the type of deficiency of both QI and YIN diabetes of glucose in urine and blood sugar increasing.Usage and consumption are: oral, and a 1.25g～2.5g (about 5～10 balls), 3 times on the one, warm water takes after meal.Treat patient's 405 examples altogether, wherein 304 examples are organized in treatment, matched group 101 examples, treatment group diabetes pill, matched group glibenclamide.Therapeutic evaluation, treatment group produce effects 45.07%, effective 48.68%, the matched group obvious effective rate is 19.81%, effective percentage is 61.39.But in disclosed document, the consumption of component is not disclosed.Because the consumption and the prescription curative effect of component are closely related, for this reason, we have found the combination of components of specific consumption through a large amount of clinical trials, have best curative effect, thereby have finished the present invention.
Summary of the invention
One of purpose of the present invention provides a kind of medicine of treatment diabetes of better efficacy.
Another purpose of the present invention provides the preparation method of this medicine.
Medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and the raw material that wherein prepares described active ingredient is:
Radix Puerariae 3600-4200 weight portion, Radix Rehmanniae 210-260 weight portion, Radix Astragali 40-110 weight portion, Radix Trichosanthis 350-430 weight portion, Stigma Maydis 350-430 weight portion, Fructus Schisandrae Chinensis 50-110 weight portion, Rhizoma Dioscoreae 10-70 weight portion and glibenclamide 0.1-0.7 gram amount part.
The active component that preferred following raw materials according is made, curative effect is better:
Radix Puerariae 4000 weight portions, Radix Rehmanniae 240 weight portions, the Radix Astragali 80 weight portions, Radix Trichosanthis 400 weight portions, Stigma Maydis 400 weight portions, Fructus Schisandrae Chinensis 80 weight portions, Rhizoma Dioscoreae 40 weight portions and glibenclamide 0.3 weight portion.
The preparation method of the active ingredient of medicine of the present invention can be that raw material is dry respectively, grinds into powder, mixes.Above-mentioned raw materials is extracted make, extracting method can be the conventional method of field of traditional Chinese medicine pharmacy, as decoction and alcohol sedimentation technique or ethanol extract from water precipitation etc." pharmaceutics of Chinese drugs " that other extracting method can be published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The preparation method of the active ingredient of medicine of the present invention is preferably got four Chinese medicines such as Radix Puerariae, Radix Rehmanniae, Stigma Maydis, Radix Trichosanthis, adds water boil 1-3 time, and each 1-7 hour, filter, be concentrated into an amount of; Other gets the Radix Astragali, Fructus Schisandrae Chinensis, Rhizoma Dioscoreae etc. and grinds to form fine powder, mixes thoroughly with concentrated solution, and drying is ground into fine powder, sieves, and the general one-tenth ball of water adds glibenclamide when folding ball, make.
The active ingredient of medicine of the present invention can be made various oral formulations such as granule, capsule, soft capsule, tablet, oral liquid, effervescent tablet, dispersible tablet or ball etc. with pharmaceutically acceptable carrier.When described medicine is pill, preferably use 2% Radix Glycyrrhizae charcoal coating, make 1200 altogether, the polishing drying, promptly.
Medicine of the present invention has nourishing kidney-YIN, supplementing QI for promoting the production of body fluid effect.Can be used for polydipsia, polyuria, polyphagia is become thin, fatigue and lack of strength, the difference of sleeping lumbago, the type of deficiency of both QI and YIN diabetes of glucose in urine and blood sugar increasing.Oral, one time 1.25 gram-2.5 grams, three times on the one, warm water takes after meal.
The specific embodiment
The preparation of embodiment 1 pill
Take by weighing raw material Radix Puerariae 4000 grams, Radix Rehmanniae 240 grams, the Radix Astragali 80 grams, Radix Trichosanthis 400 grams, Stigma Maydis 400 grams, Fructus Schisandrae Chinensis 80 grams, Rhizoma Dioscoreae 40 grams and glibenclamide 0.3 gram; Choose four Chinese medicines such as Radix Puerariae, Radix Rehmanniae, Stigma Maydis, Radix Trichosanthis, add water boil, each 5 hours, filter, be concentrated into an amount of.Other gets the Radix Astragali, Fructus Schisandrae Chinensis, Rhizoma Dioscoreae etc. and grinds to form fine powder, mixes drying thoroughly with concentrated solution.Be ground into fine powder, sieve, the general one-tenth ball of water adds glibenclamide when folding ball, with 2% Radix Glycyrrhizae charcoal coating, make 1200 altogether.The polishing drying, promptly.
The preparation of embodiment 2 tablets
Take by weighing raw material Radix Puerariae 4000 grams, Radix Rehmanniae 240 grams, the Radix Astragali 80 grams, Radix Trichosanthis 400 grams, Stigma Maydis 400 grams, Fructus Schisandrae Chinensis 80 grams, Rhizoma Dioscoreae 40 grams and glibenclamide 0.3 gram; Choose four Chinese medicines such as Radix Puerariae, Radix Rehmanniae, Stigma Maydis, Radix Trichosanthis, add water boil, each 5 hours, filter, be concentrated into an amount of; Other gets the Radix Astragali, Fructus Schisandrae Chinensis, Rhizoma Dioscoreae etc. and grinds to form fine powder, mixes thoroughly with concentrated solution, and drying is ground into fine powder, sieves, and adding glibenclamide and starch are an amount of, and magnesium stearate is granulated, added to mixing, mixing, and tabletting, promptly.
The preparation of embodiment 3 oral liquids
Take by weighing raw material Radix Puerariae 4000 grams, Radix Rehmanniae 240 grams, the Radix Astragali 80 grams, Radix Trichosanthis 400 grams, Stigma Maydis 400 grams, Fructus Schisandrae Chinensis 80 grams, Rhizoma Dioscoreae 40 grams and glibenclamide 0.3 gram; Radix Puerariae, Radix Rehmanniae, the Radix Astragali, Radix Trichosanthis, Stigma Maydis, Fructus Schisandrae Chinensis, Rhizoma Dioscoreae are decocted with water, filter, being concentrated into relative density is 1.10-1.12 (60 ℃ of surveys), add glibenclamide and stevioside dissolving, cold preservation 48 hours filters, be adjusted to total amount with distilled water, promptly.
The preparation of embodiment 4 capsules
Take by weighing raw material Radix Puerariae 4000 grams, Radix Rehmanniae 240 grams, the Radix Astragali 80 grams, Radix Trichosanthis 400 grams, Stigma Maydis 400 grams, Fructus Schisandrae Chinensis 80 grams, Rhizoma Dioscoreae 40 grams and glibenclamide 0.3 gram; Choose four Chinese medicines such as Radix Puerariae, Radix Rehmanniae, Stigma Maydis, Radix Trichosanthis, add water boil, each 5 hours, filter, be concentrated into an amount of; Other gets the Radix Astragali, Fructus Schisandrae Chinensis, Rhizoma Dioscoreae etc. and grinds to form fine powder, mixes thoroughly with concentrated solution, and drying is ground into fine powder, sieves, and adding glibenclamide and starch are an amount of, mixing, and granulation, encapsulated, promptly.
Experimental example 1
Be the definite safety of estimating clinical efficacy of the present invention and medicine, the present invention sums up case 118 examples altogether in practical clinical, be effective case and receive significant curative effect.Do not find any toxic and side effects, now the clinical trial situation is summarized as follows.
Its concrete clinical trial protocol is:
1) diagnostic criteria
A. Western medicine diagnose standard, (WHO expert consulting report in 1999)
A) diabetes fasting glucose (FPG) 〉=7.0mmol/L (126mg/dl); Or back 2 hours blood glucose (2HPG) 〉=11.1mmol/L (200mg/dl) of clothes sugar in the carbohydrate tolerance test (OGTT); Or random blood sugar 〉=11.1mmol/L (200mg/dl)
Annotate: (1) is above to be the venous plasma measured value.As blood capillary whole blood measured value, fasting glucose 〉=6.1mmol/L (110mg/dl) then; Other standards are identical.
(2) atypical symptom person, clinical diagnosis must confirm through the repeated experiments of another day.
B) impaired glucose tolerance (IGT) fasting glucose＜7.0mmol/L (126mg/dl), and back 2 hours blood glucose 〉=7.8mmol/L (140mg/dl) of clothes sugar in the carbohydrate tolerance test
Annotate: above is the venous plasma measured value.As blood capillary whole blood measured value, fasting glucose 〉=6.1mmol/L (110mg/dl) then; Other standards are identical.
C) fasting glucose infringement (IFG) 6.1mmol/L (110mg/dl)≤fasting glucose＜7.0mmol/L (126mg/dl); Back 2 hours blood glucose＜7.8mmol/L (140mg/dl) of clothes sugar in the carbohydrate tolerance test
Annotate: above is the venous plasma measured value.As blood capillary whole blood measured value, 5.6mmol/L (110mg/dl)≤fasting glucose＜7.0mmol/L (126mg/dl) then; Other standards are identical.
B. traditional Chinese medical science disease diagnostic criteria: the present invention is primarily aimed at the syndrome of deficiency of both qi and yin of thinking in the traditional Chinese medical science, and intense heat due to deficiency of YIN disease, therefore, drafts the diagnostic criteria of diabetes traditional Chinese medical science disease and is:
A) deficiency of both QI and YIN disease
Primary symptom: the dry pharynx mouth is made an uproar, fatigue and weakness.
Inferior disease: polyorexia, thirst and liking drink, the lazy speech dysphoria with feverish sensation in the chest palms and soles palpitation and insomnia of the breathing hard red constipation of urinating
Tongue arteries and veins: red tongue with a little fluid liquid thin fur or flower stripping, thready and rapid pulse without strength, or thin and string
B) intense heat due to deficiency of YIN disease
Primary symptom: the dry pharynx mouth is made an uproar, vexed fear heat.
Inferior disease: thirst and desire for cold drink, polyorexia, the red constipation of urinating
Tongue arteries and veins: red tongue with yellow fur, thready,rolling and rapid pulse, or thin stringy and rapid pulse
C) symptom scalar quantization:
The scalar quantization table
Heavy in the mild symptoms
The thirst and liking drink amount of drinking water increase slightly amount of drinking water increased more in the past half times with amount of drinking water increased more in the past 1 times with
On
The polyorexia hunger sensation obviously before the meal hunger sensation be difficult to restrain oneself and feel unbearably hungry, easily accompany hypoglycemia anti-
Should
Feverish sensation in the palms and soles feverish sensation in the palms and soles feverish sensation in the palms and soles, happiness reveal clothing and drape over one's shoulders outer brothers to hold cool object space easypro
The general activity lazy speech of promptly breathing hard of breathing hard after the fatigue of lazy speech of breathing hard, inertia is also breathed hard
Normal generation takes place in cardiopalmus once in a while, short normal generation of persistent period, longer duration
The insomnia Yi Xingnan that sleeps less falls asleep, and the difficulty of easily waking up is all night slept
2) object and method
Object and include standard in: the patient who in this hospital, selects to meet (II) diabetes according to national new Chinese medicine clinical guidance principle, meet Western medicine diagnose standard and traditional Chinese medical science disease diagnostic criteria person, select 35-68 year patient, and be signed with the patient of Informed Consent Form, 118 examples.
Wherein male case 60 people, women case 58 people are divided into two groups every group 59 people at random, first group of man case 32 people wherein, women case 27 people, second group of man's case 28 people wherein, women case 31 people.First group is the clinical control group, and patient takes gliquidone, 3 times/day/people, and each two.Second group is treatment group of the present invention, and patient takes the embodiment of the invention 1 drug prepared, and is oral, a 1.25g～2.5g (about 5～10 balls), and 3 times on the one, warm water takes after meal.Treat, be two months the course of treatment.
3) efficacy determination:
A curative effect of disease criterion:
A) produce effects
Tcm clinical practice symptom, sign are obviously improved, and the syndrome integration reduces 〉=70%; Fasting glucose and 2 hours after the meal blood glucose drop to normal range, or fasting glucose and 2 hours after the meal blood glucose descends and surpass for 40% before the treatment phase, and the glycolated hemoglobin value descends below 6.2%, or descend to surpassing and treat preceding 30%.
B) effective
Tcm clinical practice symptom, sign all take a favorable turn, and the syndrome integration reduces 〉=30%; Fasting glucose and 2 hours after the meal blood glucose descend above 20% before the treatment, but do not reach the produce effects standard.The glycolated hemoglobin value descends above 10% before the treatment, but does not reach the produce effects standard.
C) invalid
Fasting glucose and 2 hours after the meal blood glucose do not have decline, or decline reaches effective standard, and the glycolated hemoglobin value does not have decline, or decline reaches effective standard.
B mainly detects index (blood glucose) curative effect determinate standard:
A) produce effects
Fasting glucose and 2 hours after the meal blood glucose drop to normal range, or fasting glucose and 2 hours after the meal blood glucose descends and surpass for 40% before the treatment phase, and the glycolated hemoglobin value drops to normally, or descend to surpassing and treat preceding 30%.
Effectively
Fasting glucose and 2 hours after the meal blood glucose descended above 20% before the treatment phase, but did not reach the produce effects standard.The saccharifying red eggs are worth decline in vain above 10% before treating, but do not reach the produce effects standard.
B) invalid
Tcm clinical practice symptom, sign all do not have obvious improvement, even increase the weight of, card Hou Jifen reduces less than 30%; Fasting glucose and 2 hours after the meal blood glucose do not have decline, or descend and do not reach effective standard, and the saccharifying red eggs are worth in vain not have and descend, or descend and do not reach effective standard.
C, disease curative effect determinate standard:
A) clinical recovery
Tcm clinical practice symptom, sign disappear or basic the disappearance, and the syndrome integration reduces 〉=90%
B) produce effects
Tcm clinical practice symptom, sign are obviously improved, and the syndrome integration reduces 〉=70%;
C) effective
Tcm clinical practice symptom, sign are obviously improved, and the syndrome integration reduces 〉=30%
D) invalid
Tcm clinical practice symptom, sign all do not have obvious improvement, even increase the weight of, and card Hou Jifen reduces less than 30%;
Annotate: computing formula (nimodipine method) is { integration * 100%} before (integration before the treatment-treatment back integration)/treatment
4) therapeutic outcome:
A curative effect of disease result of the test;
Table 1: curative effect of disease result of the test
| Test item | Group | Obvious effective rate | Effective percentage | Inefficiency | The statistical disposition significance relatively between group |
| The blood sugar lowering curative effect | The treatment group | ????59.33 | ????81.00 | ????19.00 | P＜0.01 |
| Matched group | ????25.83 | ????67.50 | ????32.50 | ||
| Traditional Chinese medical science disease curative effect | The treatment group | ????59.67 | ????86.67 | ????13.33 | P＜0.01 |
| Matched group | ????33.33 | ????66.67 | ????33.33 |
The B doctor trained in Western medicine, mainly pick up and survey index (blood glucose) clinical trial result:
Table 2: doctor trained in Western medicine is mainly picked up and is surveyed index (blood glucose) clinical trial result
| Clinical indices | Group | Measured value | Difference statistical disposition significance relatively before and after the treatment | ||
| Before the treatment | After the treatment | Difference | |||
| Fasting glucose mmol/L | The treatment group | ??11.84± ??3.72 | 8.83±3.10 | 3.02±1.54 | ??P＜0.01 |
| Matched group | ??11.41± ??3.13 | 9.81±2.86 | 1.65±1.19 | ||
| 2 hours after the meal blood glucose mmol/L | The treatment group | ??16.46± ??5.15 | 11.35± 3.74 | 5.13±2.02 | ??P＜0.01 |
| Matched group | ??16.02±4.87 | 13.75±3.74 | 2.28±1.89 | ||
| Glycolated hemoglobin | The treatment group | 12.09± 6.25 | 9.56±2.30 | 2.52±1.89 | P＜0.01 |
| Matched group | 11.58± 5.94 | 10.45± 2.67 | 1.12±2.42 |
C traditional Chinese medical science sign efficacy determination scoring score value standard:
The scoring of traditional Chinese medical science disease, criterion;
Disease complete obiteration 0 minute
Sign makes moderate progress, and occur once in a while, but amplitude reduces 2 fens
Disease has improvement, often occur, but amplitude reduces 3 fens
Disease has improvement, but changes not obvious 4 minutes
Disease there is not change, postemphasis 5 minutes fully
Table 3: traditional Chinese medical science sign efficacy determination scoring score value standard results
| Clinical indices | Group | Mean scores | Difference statistical disposition significance relatively before and after the treatment | ||
| Before the treatment | After the treatment | Difference | |||
| Thirst and liking drink | The treatment group | ????3.68 | ????1.27 | ????2.41 | ????P＜0.05 |
| Matched group | ????3.52 | ????2.87 | ????0.65 | ||
| Polyorexia | The treatment group | ????4.01 | ????1.85 | ????2.16 | ????P＜0.05 |
| Matched group | ????4.24 | ????3.06 | ????1.18 | ||
| Burning sensation on palms and soles | The treatment group | ????3.23 | ????1.25 | ????1.98 | ????P＜0.05 |
| Matched group | ????3.56 | ????2.43 | ????1.13 | ||
| The lazyness of breathing hard language | The treatment group | ????3.83 | ????1.15 | ????2.68 | ????P＜0.05 |
| Matched group | ????3.05 | ????1.89 | ????1.16 | ||
| Palpitation and insomnia | The treatment group | ????4.63 | ????1.18 | ????3.45 | ????P＜0.05 |
| Matched group | ????4.08 | ????3.09 | ????0.99 | ||
By above mathematical statistics analysis, according to table 1-3 as can be known, medicine of the present invention no matter its aspect the clinical efficacy of treatment diabetes cases still doctor trained in Western medicine detect index (blood glucose) and traditional Chinese medical science sign treatment aspect is all obviously high and matched group (P＜0.01, or P＜0.05), it is remarkable to illustrate that medicine of the present invention is used for the treatment of the diabetes effect.
Claims (7)
1. medicine for the treatment of diabetes, it is characterized in that it is made up of active ingredient and/or pharmaceutically acceptable carrier, the raw material that wherein prepares described active ingredient is: Radix Puerariae 3600-4200 weight portion, Radix Rehmanniae 210-260 weight portion, Radix Astragali 40-110 weight portion, Radix Trichosanthis 350-430 weight portion, Stigma Maydis 350-430 weight portion, Fructus Schisandrae Chinensis 50-110 weight portion, Rhizoma Dioscoreae 10-70 weight portion and glibenclamide 0.1-0.7 gram amount part.
2. medicine according to claim 1, the raw material that wherein prepares described active ingredient comprises: Radix Puerariae 4000 weight portions, Radix Rehmanniae 240 weight portions, the Radix Astragali 80 weight portions, Radix Trichosanthis 400 weight portions, Stigma Maydis 400 weight portions, Fructus Schisandrae Chinensis 80 weight portions, Rhizoma Dioscoreae 40 weight portions and glibenclamide 0.3 gram weight part.
3. medicine according to claim 1 and 2, it is a peroral dosage form.
4. medicine according to claim 3, it is granule, capsule, soft capsule, tablet, oral liquid, effervescent tablet, dispersible tablet or pill.
5. the preparation method of any one described medicine among the claim 1-4, it comprises raw material dry respectively, grinds into powder, mixes.
6. the preparation method of any one described medicine among the claim 1-4, it comprises and adds water boil by four Chinese medicines such as getting Radix Puerariae, Radix Rehmanniae, Stigma Maydis, Radix Trichosanthis, one time five hours, filter, be concentrated into an amount of.Other gets the Radix Astragali, Fructus Schisandrae Chinensis, Rhizoma Dioscoreae etc. and grinds to form fine powder, mixes drying thoroughly with concentrated solution.Be ground into fine powder, sieve, the general one-tenth ball of water, glibenclamide adds when folding ball.
7. preparation method according to claim 6, it also comprises with 2% Radix Glycyrrhizae charcoal coating, makes 1200 altogether, the polishing drying, promptly.
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| CN 200410073887 CN1616010A (en) | 2004-09-08 | 2004-09-08 | Medicine for treating diabetes and its preparing method |
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| CN 200410073887 CN1616010A (en) | 2004-09-08 | 2004-09-08 | Medicine for treating diabetes and its preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006122454A1 (en) * | 2005-05-18 | 2006-11-23 | Guangzhou Zhongyi Pharmaceutical Company Limited | A pharmaceutical composition for treating diabetes and preparation method thereof |
| CN102308993A (en) * | 2011-08-01 | 2012-01-11 | 滕树财 | Health-care food with hypoglycemic effect and hypolipidemic effect, and its preparation method |
-
2004
- 2004-09-08 CN CN 200410073887 patent/CN1616010A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006122454A1 (en) * | 2005-05-18 | 2006-11-23 | Guangzhou Zhongyi Pharmaceutical Company Limited | A pharmaceutical composition for treating diabetes and preparation method thereof |
| CN102308993A (en) * | 2011-08-01 | 2012-01-11 | 滕树财 | Health-care food with hypoglycemic effect and hypolipidemic effect, and its preparation method |
| CN102308993B (en) * | 2011-08-01 | 2012-09-05 | 滕树财 | Health-care food with hypoglycemic effect and hypolipidemic effect, and its preparation method |
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