CN1596113B - δ受体激动剂化合物在制备治疗抑郁症的药物中的应用 - Google Patents

δ受体激动剂化合物在制备治疗抑郁症的药物中的应用 Download PDF

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Publication number
CN1596113B
CN1596113B CN028237099A CN02823709A CN1596113B CN 1596113 B CN1596113 B CN 1596113B CN 028237099 A CN028237099 A CN 028237099A CN 02823709 A CN02823709 A CN 02823709A CN 1596113 B CN1596113 B CN 1596113B
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composition
formula
mood disorder
treating
alkyl
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Expired - Fee Related
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CN028237099A
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English (en)
Chinese (zh)
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CN1596113A (zh
Inventor
张宽仁
威廉·彭德格斯特
彼得·J·真戈
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Wersi Refco Group Ltd
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Mount Cook Biosciences Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN028237099A 2001-10-29 2002-10-29 δ受体激动剂化合物在制备治疗抑郁症的药物中的应用 Expired - Fee Related CN1596113B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US34008401P 2001-10-29 2001-10-29
US60/340,084 2001-10-29
US33788701P 2001-11-02 2001-11-02
US60/337,887 2001-11-02
PCT/US2002/034421 WO2003037342A1 (en) 2001-10-29 2002-10-29 Method of treating depression with delta receptor agonist compounds

Publications (2)

Publication Number Publication Date
CN1596113A CN1596113A (zh) 2005-03-16
CN1596113B true CN1596113B (zh) 2010-05-26

Family

ID=26990913

Family Applications (1)

Application Number Title Priority Date Filing Date
CN028237099A Expired - Fee Related CN1596113B (zh) 2001-10-29 2002-10-29 δ受体激动剂化合物在制备治疗抑郁症的药物中的应用

Country Status (11)

Country Link
US (1) US7030124B2 (OSRAM)
EP (1) EP1450807B1 (OSRAM)
JP (1) JP4892654B2 (OSRAM)
CN (1) CN1596113B (OSRAM)
CA (1) CA2464471C (OSRAM)
MX (1) MXPA04004059A (OSRAM)
NO (1) NO20042257L (OSRAM)
PL (1) PL371297A1 (OSRAM)
RU (1) RU2314809C2 (OSRAM)
TW (1) TW200300089A (OSRAM)
WO (1) WO2003037342A1 (OSRAM)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7229994B2 (en) * 2001-05-18 2007-06-12 Astrazeneca Ab 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders
US8476280B2 (en) * 2002-05-09 2013-07-02 Versi Group, Llc Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists
SE0203303D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
US7314880B2 (en) * 2003-01-02 2008-01-01 Mount Cook Biosciences, Inc. Cardioprotective delta opioid receptor agonists and methods of using same
AU2004278414B2 (en) 2003-10-01 2012-05-24 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
DK1781631T3 (da) * 2004-08-02 2012-05-14 Astrazeneca Ab Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf
SE0401968D0 (sv) * 2004-08-02 2004-08-02 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
CA2643677C (en) * 2005-04-14 2015-06-23 Mount Cook Biosciences, Inc. Compositions of novel opioid compounds and method of use thereof
WO2007027987A2 (en) 2005-09-02 2007-03-08 Mount Cook Biosciences, Inc. Method of treating parkinson's disease with diarylmethylpiperazine compounds exhibiting delta receptor agonist activity
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
EP2296657A4 (en) * 2008-05-20 2011-12-14 Astrazeneca Ab METHOD FOR TREATING HEAVY DEPRESSION WITH FEARING STATES
CN103467460A (zh) * 2013-09-23 2013-12-25 昆明理工大学 一类含噻吩环和苄基的二芳基甲基哌嗪化合物及其应用
CN105646151B (zh) * 2016-02-26 2018-06-29 山西大学 一种炔类化合物及其制备方法和该化合物的用途
EP3436013A4 (en) 2016-03-31 2019-11-13 Versi Group, LLC DELTA OPIOID AGONIST, MU OPIOID ANTAGONIST COMPOSITIONS AND METHOD FOR TREATING MORBUS PARKINSON

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5658908A (en) * 1992-02-03 1997-08-19 Delta Pharmaceuticals, Inc. Opioid diarylmethylpiperazines and piperdines

Family Cites Families (17)

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Publication number Priority date Publication date Assignee Title
US5A (en) * 1836-08-10 Thomas Blanchard Machine for mortising solid wooden shells of ships' tackle-blocks
US5985880A (en) * 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
US5807858A (en) * 1996-06-05 1998-09-15 Delta Pharmaceutical, Inc. Compositions and methods for reducing respiratory depression
US20020052007A1 (en) 1992-02-03 2002-05-02 Chang Kwen Jen Diarylmethylbenzylpiperazines and corresponding halobenzyl derivatives
US5681830A (en) 1992-02-03 1997-10-28 Delta Pharmaceuticals, Inc. Opioid compounds
US5574159A (en) 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
RU2133744C1 (ru) * 1993-07-30 1999-07-27 Дельта Фармасьютикалз, Инк. Пиперазиновые соединения
US6046200A (en) 1994-09-09 2000-04-04 The United States Of America As Represented By The Secretary Of The Army Compositions having neuroprotective and analgesic activity
SE9504661D0 (sv) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
GB9709972D0 (en) * 1997-05-19 1997-07-09 Pfizer Ltd Tetrazoles
GB9804734D0 (en) 1998-03-05 1998-04-29 Pfizer Ltd Compounds
EP0952154B1 (en) * 1998-04-16 2004-08-18 Pfizer Products Inc. N-acyl and N-aroyl aralkyl amides
SE9904674D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904675D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904673D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
GB0017256D0 (en) 2000-07-13 2000-08-30 Merck Sharp & Dohme Therapeutic agents
US7229994B2 (en) 2001-05-18 2007-06-12 Astrazeneca Ab 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5658908A (en) * 1992-02-03 1997-08-19 Delta Pharmaceuticals, Inc. Opioid diarylmethylpiperazines and piperdines

Also Published As

Publication number Publication date
JP4892654B2 (ja) 2012-03-07
CA2464471C (en) 2012-05-15
RU2004115748A (ru) 2005-03-27
TW200300089A (en) 2003-05-16
US7030124B2 (en) 2006-04-18
WO2003037342A1 (en) 2003-05-08
RU2314809C2 (ru) 2008-01-20
PL371297A1 (en) 2005-06-13
NO20042257L (no) 2004-06-24
CA2464471A1 (en) 2003-05-08
EP1450807B1 (en) 2013-12-25
US20030144299A1 (en) 2003-07-31
JP2005508363A (ja) 2005-03-31
MXPA04004059A (es) 2005-03-31
EP1450807A4 (en) 2008-06-25
EP1450807A1 (en) 2004-09-01
CN1596113A (zh) 2005-03-16

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