CN1590545A - 攻击SARS病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及应用 - Google Patents
攻击SARS病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及应用 Download PDFInfo
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Abstract
本发明提供了攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其在制备治疗SARS以及与其感染相关的任何疾病的药物中的应用。它为双链RNA分子并且与具有以下特征的核苷酸序列至少70%的同源度:正、负义链的长度均为21个核苷酸,正、负义链各自的3’端为两个连续的T,两条链除去3’端的TT以外的19个核苷酸上的碱基互补形成双链,正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒mRNA分子中连续两个碱基为A的核苷酸之后的19个核苷酸序列完全一致,每条链的碱基为G或C的核苷酸数量之和占除去3’端的TT以外的19个核苷酸数量的比例为30%-70%,序列(I)负链和其任意一个位置的突变体和已知人类基因和基因表达片段无同源性。
Description
技术领域
本发明属于基因工程领域,具体地说涉及攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰RNA分子(SiRNA)及其应用。
背景技术
SARS是一种仅有五个月历史的新型急性传染病。第一例SARS病人于2002年11月在我国广东省被发现,在2003年2月间此病在广东得以蔓延,到2003年2月中旬,广东已有确诊人数达305例,其中死亡5例。当时因为此病的临床症状与其它病原体引起的非典型性肺炎类似,所以也将其笼统地称为非典型性肺炎(其本来的医学概念是指不是因细菌感染而是有其它病原体,主要是衣原体、支原体等微生物引起的肺部炎症)。由于此病的病因不清,不知道如何切断其传染途经,再加上没有任何的有效疗法,使得此病在过去的两个月中迅速传播到中国的大部地区和世界上的许多国家。根据WHO到2003年5月1号的统计,全球共有29个国家和地区有SARS感染病人,累计共有SARS病人5663例,其中死亡372例。中国卫生部2003年5月1日的最新疫情报道,中国大陆(不包括香港、澳门、和台湾地区)共有26个省、自治区、和直辖市发现SARS病人,累计总感染人数为3638例,其中死亡170人,另外还有2291个疑似病例。
SARS的病因在世界卫生组织和其成员国的科学家们的努力下,已经确定为一种新的冠状病毒,第一个SARS病毒全部基因组序列的测定由加拿大的科学家在2003年4月13号首先完成(基因文库登录号NC_004718)。此后,又有来自不同病人的SARS病毒的全基因组序列被美国、中国北京、和中国香港的科学家们独立地破译。到2003年5月10号,共有5个SARS病毒全基因组序列在基因文库中登录,它们分别是NC_004718,AY278488,AY278491、AY278544,和AY278741。
随着SARS病毒基因序列的破译,人们已经成功地研发出可以准确诊断SARS的有效方法,但SARS感染和大部份其它病毒感染一样,最大的问题是没有任何有效和特异的治疗手段,这使得其急性死亡率居高不下,一直在5%-10%左右。可以预测,在有效的SARS病毒疫苗问世之前,如何找到一种有效治疗SARS感染的药物是对整个人类的一个巨大挑战。
发明内容
本发明所要解决的技术问题是提供攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)。
本发明另一个所要解决的技术问题是提供上述小干扰核糖核酸分子在制备治疗SARS以及与SARS感染相关的任何疾病的药物中的应用。
本发明提供的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),它为双链RNA分子并且其核苷酸序列与具有以下特征的核苷酸序列(I)至少70%的同源度:正义链和负义链的长度均为21个核苷酸,正义链和负义链各自的3’端为两个连续的脱氧胸苷酸(TT),两条链除去3’端的TT以外的19个核苷酸上的碱基互补形成双链,正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒mRNA分子中连续两个碱基为腺嘌呤(A)的核苷酸之后的19个核苷酸序列完全一致,每条链中的碱基为鸟嘌呤(G)的核苷酸及胞嘧啶(C)的核苷酸数量之和占除去3’端的TT以外的19个核苷酸数量的比例为大于30%小于70%(即G/C比例),核苷酸序列(I)和其任意一个位置的核苷酸突变体和已知人类基因和基因表达片段无同源性。
“无同源性”在此是指核苷酸序列(I)和其任意一个位置的核苷酸突变体和已知人类基因和基因表达片段无100%的相同。
根据以上所述,核苷酸序列(I)的负义链的21个核苷酸上的碱基和被攻击的SARS病毒的mRNA对应区域序列的碱基完全互补,其中3’端的两个TT和mRNA对应区域5’端的两个AA互补。
上述小干扰RNA分子(SiRNA)为人工合成,正义链和负义链各自的3’末端有两个脱氧胸甘酸(TT),其它19个核苷酸的碱基可以是腺嘌呤(A)、鸟嘌呤(G)、胞嘧啶(C)或尿嘧啶(U);两条链除去3’端的TT以外的19个核苷酸上的碱基互补(A和U,C和G)形成双链,但它们3’端的TT却以单链的形式存在。
当被攻击的SARS病毒mRNA分子中出现两个以上连续的碱基为腺嘌呤(A)的核苷酸时,上述“正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒mRNA分子中连续两个碱基为腺嘌呤(A)的核苷酸之后的19个核苷酸序列完全一致,”可以被理解为“正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒mRNA分子中任意两个连续的碱基为腺嘌呤(A)的核苷酸之后的19个核苷酸序列完全一致。”
SARS病毒的整个基因组的所有核苷酸几乎都有效地用于编码和各种功能和结构蛋白,不仅其整个线性序列都有相对应的编码蛋白外,在多个区域还有移位重复使用序列编码多个蛋白的现象。它除了编码其它冠状病毒已知功能和结构蛋白,如多功能聚合酶(polyprotein)、膜蛋白(M)、刺蛋白(S),核复合体蛋白(N)、和小分子膜蛋白(E)以外,还可能编码五种未知功能的蛋白(uncharacterizedprotein,UP1-5)。SARS病毒是一种单链RNA病毒,其基因组是有一条正义链的RNA分子组成,当病毒感染进入细胞后,组成病毒基因组的正义链RNA分子本身无法进行复制,它需要依靠其本身为模板转录形成一条负链RNA(此过程有正义链RNA直接翻译合成的RNA依赖的RNA聚合酶来催化进行),有此两条RNA互补形成一个复制复合体。此复合体的负义链一方面可转录编码各种病毒蛋白的mRNA,另一方面可以转录形成大量的正义链的基因组RNA,此正义链RNA与上述mRNA转录形成的各种病毒蛋白装配在一起而完成病毒的复制。从SARS病毒复制的过程来看,其是一种比较容易被SiRNA攻击的病毒。首先因为组成病毒基因组的正义链本身可以受到SiRNA攻击而降解;第二是编码病毒蛋白的所有mRNA可以用SiRNA来攻击;第三是和病毒复制直接相关的、由复制复合体转录形成的正义链RNA也可被SiRNA来作用而降解。因此特异针对SARS病毒的SiRNA分子可以起到治疗SARS以及与SARS感染相关的疾病。
SARS病毒多功能聚合酶在病毒的复制和繁殖中处于中心作用,尤其是多功能聚合酶中的RNA依赖的RNA聚合酶是整个病毒复制和繁殖过程中的关键。此酶属于RNA依赖的RNA聚合酶,不存在于任何人体细胞,因此SARS病毒复制和繁殖过程中每一次遗传信息复制和传递均需要它的作用下完成,另外病毒所有结构蛋白的mRNA的转录也要通过它的催化下完成。
SARS病毒编码的刺蛋白(S)对于病毒致病过程中的具有极大的重要性,它是SARS病毒表面最为重要的蛋白,除了本身对病毒结构的完整至关重要外,S蛋白在SARS病毒的致病中的多方面起到十分重要的作用。第一、SARS病毒和细胞表面特异性病毒受体结合的需要S蛋白来介导;第二、病毒和细胞的融合和进入细胞的过程也是有S蛋白来介导;第三、病毒感染细胞后可大量合成S蛋白并将其分布在感染细胞的表面,这些S蛋白是造成属主免疫系统杀伤感染细胞的重要原因,而此也是SARS病毒感染致死的重要因素。
因此,上述SiRNA,以攻击SARS病毒多功能聚合酶mRNA分子中的RNA依赖的RNA聚合酶区域或S蛋白mRNA分子为效果更好,即前述的核苷酸序列(I)应当还具有以下特征:其正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒多功能聚合酶mRNA分子中的RNA依赖的RNA聚合酶区域或被攻击的SARS病毒刺蛋白(S蛋白)mRNA分子中的的连续两个碱基为A的核苷酸之后的19个核苷酸序列完全一致,其负义链相应配合。
当被攻击的SARS病毒多功能聚合酶mRNA分子中的RNA依赖的RNA聚合酶区域或被攻击的SARS病毒刺蛋白(S蛋白)mRNA分子中出现两个以上连续的碱基为腺嘌呤(A)的核苷酸时,上述“正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒mRNA分子中连续两个碱基为腺嘌呤(A)的核苷酸之后的19个核苷酸序列完全一致,”仍然可以被理解为“正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒mRNA分子中任意两个连续的碱基为腺嘌呤(A)的核苷酸之后的19个核苷酸序列完全一致。”
以攻击SARS病毒多功能聚合酶mRNA分子中的RNA依赖的RNA聚合酶区域或S蛋白mRNA分子而言,其SiRNA以更具备以下特征为治疗效果更佳:即核苷酸序列(I)的GC比例在40%到60%之间;它的正义链5’端的第一个核苷酸的碱基为鸟嘌呤(G)、胞嘧啶(C)、和尿嘧啶(U)中的一种,其负义链相应配合;其序列中不具有连续三个以上碱基为G或C的核苷酸也不具有连续四个以上碱基为A或U的核苷酸。
上段中“它的正义链5’端的第一个核苷酸的碱基为鸟嘌呤(G)、胞嘧啶(C)、和尿嘧啶(U)中的一种”的意思是,当被攻击的SARS病毒多功能聚合酶mRNA分子中的RNA依赖的RNA聚合酶区域或被攻击的SARS病毒刺蛋白(S蛋白)mRNA分子中出现两个以上连续的碱基为腺嘌呤(A)的核苷酸时,正义链自5’端开始的19个核苷酸序列和该两个以上连续的碱基为腺嘌呤(A)的核苷酸中的最后两个核苷酸之后的19个核苷酸序列完全一致,”。
就所有攻击SARS病毒mRNA分子的SiRNA而言,它具备以上两段的特征,其治疗效果都将更好。
经发明人的研究,确立了长度为29744个核苷酸的SARS病毒共同基准序列(见序列表的No.1序列),对此序列进一步研究发现,在其中确定了编码RNA依赖的RNA聚合酶的区域在基因组的13372到16166之间,编码S蛋白的区域在21492到25259之间。以下列举了攻击RNA依赖的RNA聚合酶的SiRNA分子(表1)和攻击S蛋白的(表2)的小干扰RNA(SiRNA)的具体特征,它们均为上述核苷酸序列(I)的具体例证,它们的反义链的序列表列于本说明书的最后部分。
表1、攻击RNA依赖的RNA聚合酶的SiRNA分子
G/C比
序列号 正义链序列 反义链序列 目标基因 作用范围 例(%) 分子量
CUAAUUGCUGUC UGGAAGCGACAG
2 GCUUCCATT CAAUUAGTT RNA聚合酶 13255…13275 47 13459.4
UUGCUGUCGCUU CUCCUGGAAGCG
3 CCAGGAGTT ACAGCAATT RNA聚合酶 13259…13279 58 13489.6
GGAUGAGGAAGG UAAAUUGCCUUC
4 CAAUUUATT CUCAUCCTT RNA聚合酶 13280…13300 42 13444.3
GAGGCAUACUAU GUUAGACAUAGU
5 GUCUAACTT AUGCCUCTT RNA聚合酶 13322…13342 42 13444.3
CUACCAACAUGA AGUCUCUUCAUG
6 AGAGACUTT UUGGUAGTT RNA聚合酶 13340…13360 42 13444.3
GAUUGUCCAGCG CAGCAACCGCUG
7 GUUGCUGTT GACAAUCTT RNA聚合酶 13377…13397 58 13489.6
GUUUAGAGUAGA GUCACCAUCUAC
8 UGGUGACTT UCUAAACTT RNA聚合酶 13412…13432 42 13444.3
UGGCUGAUUUAG GCAUAGACUAAA
9 UCUAUGCTT UCAGCCATT RNA聚合酶 13474…13494 42 13444.3
GAAGGAUUGGUA GAAGUCAUACCA
10 UGACUUCTT AUCCUUCTT RNA聚合酶 13580…13600 42 13444.3
GGAUUGGUAUGA UACGAAGUCAUA
11 CUUCGUATT CCAAUCCTT RNA聚合酶 13583…13603 42 13444.3
UCCUGACAUCUU UACGCGUAAGAU
12 ACGCGUATT GUCAGGATT RNA聚合酶 13607…13627 47 13459.4
CUUAGGUGAGCG GCGUACACGCUC
13 UGUACGCTT ACCUAAGTT RNA聚合酶 13634…13654 58 13489.6
GACUGUACAAUU AUCGCAGAAUUG
14 CUGCGAUTT UACAGUCTT RNA聚合酶 13667…13687 42 13444.3
UUCUGCGAUGCU CACGCAUAGCAU
15 AUGCGUGTT CGCAGAATT RNA聚合酶 13677…13697 53 13474.5
CUGGUACGAUUU AUCACCGAAAUC
16 CGGUGAUTT GUACCAGTT RNA聚合酶 13748…13768 47 13459.4
GAGAGACUUUGU CGAAGAGACAAA
17 CUCUUCGTT GUCUCUCTT RNA聚合酶 13935…13955 47 13459.4
CUGUUUGGAUGA ACACCUAUCAUC
18 UAGGUGUTT CAAACAGTT RNA聚合酶 14003…14023 42 13444.3
CUUACAUAGCUC GAGACGCGAGCU
19 GCGUCUCTT AUGUAAGTT RNA聚合酶 14183…14203 53 13474.5
GGAAGGAAGUUC UUCAACAGAACU
20 UGUUGAATT UCCUUCCTT RNA聚合酶 14393…14413 42 13444.3
CACUUCUUCUUU CCUGAGCAAAGA
21 GCUCAGGTT AGAAGUGTT RNA聚合酶 14418…14438 47 13459.4
CGCUGCUAUCAG AUAAUCACUGAU
22 UGAUUAUTT AGCAGCGTT RNA聚合酶 14444…14464 42 13444.3
UCUGCCAACAAU AUCACACAUUGU
23 GUGUGAUTT UGGCAGATT RNA聚合酶 14480…14500 42 13444.3
CUCCUAUUCGUA CUUCAACUACGA
24 GUUGAAGTT AUAGGAGTT RNA聚合酶 14508…14528 42 13444.3
UGCCAACCAAGU AACGAUUACUUG
25 AAUCGUUTT GUUGGCATT RNA聚合酶 14570…14590 42 13444.3
UCUGGAUAAAUC ACCAGCUGAUUU
26 AGCUGGUTT AUCCAGATT RNA聚合酶 14594…14614 42 13444.3
GUAUGCCAUUAG CUUUGCACUAAU
27 UGCAAAGTT GGCAUACTT RNA聚合酶 14738…14758 42 13444.3
GAAUAGAGCUCG UACGGUGCGAGC
28 CACCGUATT UCUAUUCTT RNA聚合酶 14756…14776 53 13474.5
UAGAGCUCGCAC AGCUACGGUGCG
29 CGUAGCUTT AGCUCUATT RNA聚合酶 14759…14779 58 13489.6
GUCAAUAGCCGC UCUAGUGGCGGC
30 CACUAGATT UAUUGACTT RNA聚合酶 14834…14854 53 13474.5
UGUGACAGAGCC UAGGCAUGGCUC
31 AUGCCUATT UGUCACATT RNA聚合酶 14967…14987 53 13474.5
CAUGCUUAGGAU GGCCAUUAUCCU
32 AAUGGCCTT AAGCAUGTT RNA聚合酶 14987…15007 47 13459.4
UGGCCUCUCUUG GCAAGAACAAGA
33 UUCUUGCTT GAGGCCATT RNA聚合酶 15001…15021 53 13474.5
CUUAUCACACCG GUAGAAACGGUG
34 UUUCUACTT UGAUAAGTT RNA聚合酶 15044…15064 42 13444.3
CGAGUGUGCGCA UAAUACUUGCGC
35 AGUAUUATT ACACUCGTT RNA聚合酶 15074…15094 47 13459.4
GUGAGAUGGUCA CCACACAUGACC
36 UGUGUGGTT AUCUCACTT RNA聚合酶 15094…15114 53 13474.5
CCAGGUGGAACA CGGAUGAUGUUC
37 UCAUCCGTT CACCUGGTT RNA聚合酶 15132…15152 58 13489.6
CAUCAUCCGGUG GUAGCAUCACCG
38 AUGCUACTT GAUGAUGTT RNA聚合酶 15142…15162 53 13474.5
GCUGUUACAGCC UUACAUUGGCUG
39 AAUGUAATT UAACAGCTT RNA聚合酶 15198…15218 42 13444.3
GAUAGCUGACAA GACAUACUUGUC
40 GUAUGUCTT AGCUAUCTT RNA聚合酶 15245…15265 42 13444.3
GUAUGUCCGCAA UUGUAGAUUGCG
41 UCUACAATT GACAUACTT RNA聚合酶 15257…15277 42 13444.3
UCUACAACACAG AUAGAGCCUGUG
42 GCUCUAUTT UUGUAGATT RNA聚合酶 15269…15289 42 13444.3
CACAGGCUCUAU GACACUCAUAGA
43 GAGUGUCTT GCCUGUGTT RNA聚合酶 15276…15296 53 13474.5
CAGUAACUAUGC UUGAGCCGCAUA
44 GGCUCAATT GUUACUGTT RNA聚合酶 15404…15424 47 13459.4
CUAUGCGGCUCA UAAACCUUGAGC
45 AGGUUUATT CGCAUAGTT RNA聚合酶 15410…15430 47 13459.4
UGUGUUCAUGUC UGCCUCAGACAU
46 UGAGGCATT GAACACATT RNA聚合酶 15476…15496 47 13459.4
UGUUGGACUGAG GGUCAGUCUCAG
47 ACUGACCTT UCCAACATT RNA聚合酶 15498…15518 53 13474.5
CAAGGAGAUGAU ACACGUAAUCAU
48 UACGUGUTT CUCCUUGTT RNA聚合酶 15567…15587 42 13444.3
GGAGAUGAUUAC GGUACACGUAAU
49 GUGUACCTT CAUCUCCTT RNA聚合酶 15570…15590 47 13459.4
GAAUAUUAGGCG CAGCCUGCGCCU
50 CAGGCUGTT AAUAUUCTT RNA聚合酶 15610…15630 53 13474.5
UAUUAGGCGCAG AAACAGCCUGCG
51 GCUGUUUTT CCUAAUATT RNA聚合酶 15613…15633 47 13459.4
GGUUCGUGUCAC AUAGCCAGUGAC
52 UGGCUAUTT ACGAACCTT RNA聚合酶 15676…15696 53 13474.5
CAUCCUAAUCAG CAUACUCCUGAU
53 GAGUAUGTT UAGGAUGTT RNA聚合酶 15717…15737 42 13444.3
CUAAUGAUAACA CGUGAGGUGUUA
54 CCUCACGTT UCAUUAGTT RNA聚合酶 15826…15846 42 13444.3
UGAUAACACCUC GUACCGUGAGGU
55 ACGGUACTT GUUAUCATT RNA聚合酶 15830…15850 47 13459.4
UUCACAGACUUC ACGAAGUGAAGU
56 ACUUCGUTT CUGUGAATT RNA聚合酶 15926…15946 42 13444.3
GUGCUGCUAUGA GACAUGGUCAUA
57 CCAUGUCTT GCAGCACTT RNA聚合酶 15983…16003 53 13474.5
CUGUAUCUAGGA UCAUACCUCCUA
58 GGUAUGATT GAUACAGTT RNA聚合酶 16086…16106 42 13444.3
表2:攻击S蛋白的SiRNA分子
G/C比例
序列号 正义链序列 反义链序列 目标基因 作用范围 (%) 分子量
GCUCCUAAUUACA GUUGAGUGUAAUU
59 CUCAACTT AGGAGCTT 刺蛋白 76…96 42 13444.3
UCAAAUGUUGUCC AACCACGGACAAC
60 GUGGUUTT AUUUGATT 刺蛋白 280…300 42 13444.3
CAACAAGUCACAG CACCGACUGUGAC
61 UCGGUGTT UUGUUGTT 刺蛋白 321…341 53 13474.5
CAAGUCACAGUCG AAUCACCGACUGU
62 GUGAUUTT GACUUGTT 刺蛋白 324…344 47 13459.4
GUCACAGUCGGUG AAUAAUCACCGAC
63 AUUAUUTT UGUGACTT 刺蛋白 327…347 42 13444.3
CACUUACGAGAGU ACACAAACUCUCG
64 UUGUGUTT UAAGUGTT 刺蛋白 538…558 42 13444.3
CCUAUAGAUGUAG CACGAACUACAUC
65 UUCGUGTT UAUAGGTT 刺蛋白 601…621 42 13444.3
GUUGCCUCUUGGU GUUAAUACCAAGA
66 AUUAACTT GGCAACTT 刺蛋白 660…680 42 13444.3
GCCAACUACAUUU GAGCAUAAAUGUA
67 AUGCUCTT GUUGGCTT 刺蛋白 771…791 42 13444.3
UGGUACAAUCACA AGCAUCUGUGAUU
68 GAUGCUTT GUACCATT 刺蛋白 804…824 42 13444.3
UCACAGAUGCUGU CAAUCAACAGCAU
69 UGAUUGTT CUGUGATT 刺蛋白 812…832 42 13444.3
UCCACUUGCUGAA UUUGAGUUCAGCA
70 CUCAAATT AGUGGATT 刺蛋白 840…860 42 13444.3
UGCUCUGUUAAGA CAAAGCUCUUAAC
71 GCUUUGTT AGAGCATT 刺蛋白 859…879 42 13444.3
GGAAUUUACCAGA UAGAGGUCUGGUA
72 CCUCUATT AAUUCCTT 刺蛋白 889…909 42 13444.3
CCUUUAAGUGCUA ACGCCAUAGCACU
73 UGGCGUTT UAAAGGTT 刺蛋白 1085…1105 47 13459.4
GUGCUAUGGCGUU GGCAGAAACGCCA
74 UCUGCCTT UAGCACTT 刺蛋白 1092…1112 58 13489.6
GACAAAUAGCGCC UGUCCUGGCGCUA
75 AGGACATT UUUGUCTT 刺蛋白 1181…1201 53 13474.5
UAGCGCCAGGACA CCAGUUUGUCCUG
76 AACUGGTT GCGCUATT 刺蛋白 1187…1207 58 13489.6
UUGCCAGAUGAUU CCAUGAAAUCAUC
77 UCAUGGTT UGGCAATT 刺蛋白 1231…1251 42 13444.3
CCUUACAGAGUUG GUACUACAACUCU
78 UAGUACTT GUAAGGTT 刺蛋白 1474…1494 42 13444.3
UGGACUCACUGGU ACCAGUACCAGUG
79 ACUGGUTT AGUCCATT 刺蛋白 1587…1607 53 13474.5
CCAUUUCAACAAU GGCCAAAUUGUUG
80 UUGGCCTT AAAUGGTT 刺蛋白 1636…1656 42 13444.3
CAAUUUGGCCGUG AAACAUCACGGCC
81 AUGUUUTT AAAUUGTT 刺蛋白 1645…1665 42 13444.3
UUUGGCCGUGAUG CAGAAACAUCACG
82 UUUCUGTT GCCAAATT 刺蛋白 1648…1668 47 13459.4
GUGUAAUUACACC GUUCCAGGUGUAA
83 UGGAACTT UUACACTT 刺蛋白 1742…1762 42 13444.3
UUACACCUGGAAC GCAUUUGUUCCAG
84 AAAUGCTT GUGUAATT 刺蛋白 1748…1768 42 13444.3
UGCUUCAUCUGAA AGCAACUUCAGAU
85 GUUGCUTT GAAGCATT 刺蛋白 1764…1784 42 13444.3
GAUGUUAACUGCA CAUCAGUGCAGUU
86 CUGAUGTT AACAUCTT 刺蛋白 1795…1815 42 13444.3
CUGCACUGAUGUU UGUAGAAACAUCA
87 UCUACATT GUGCAGTT 刺蛋白 1803…1823 42 13444.3
UUCAUGCAGAUCA GUGAGUUGAUCUG
88 ACUCACTT CAUGAATT 刺蛋白 1826…1846 42 13444.3
GCAGGCUGUCUUA CUCCUAUAAGACA
89 UAGGAGTT GCCUGCTT 刺蛋白 1894…1914 53 13474.5
CACCAUUGCUAUA AGUAGGUAUAGCA
90 CCUACUTT AUGGUGTT 刺蛋白 2073…2093 42 13444.3
GUAAUGCCUGUUU CCAUAGAAACAGG
91 CUAUGGTT CAUUACTT 刺蛋白 2119…2139 42 13444.3
UGCCUGUUUCUAU UUAGCCAUAGAAA
92 GGCUAATT CAGGCATT 刺蛋白 2123…2143 42 13444.3
UAUGUACAUCUGC AUCUCCGCAGAUG
93 GGAGAUTT UACAUATT 刺蛋白 2160…2180 42 13444.3
UGUGCUAAUUUGC GGAGAAGCAAAUU
94 UUCUCCTT AGCACATT 刺蛋白 2188…2208 42 13444.3
CUAAAUCGUGCAC CUGAGAGUGCACG
95 UCUCAGTT AUUUAGTT 刺蛋白 2230…2250 47 13459.4
UCGUGCACUCUCA AAUACCUGAGAGU
96 GGUAUUTT GCACGATT 刺蛋白 2235…2255 47 13459.4
CAGGAUCGCAACA CACGUGUGUUGCG
97 CACGUGTT AUCCUGTT 刺蛋白 2263…2283 58 13489.6
CACACGUGAAGUG AGCGAACACUUCA
98 UUCGCUTT CGUGUGTT 刺蛋白 2274…2294 53 13474.5
GUGUUCGCUCAAG GUUUGACUUGAGC
99 UCAAACTT GAACACTT 刺蛋白 2284…2304 47 13459.4
UAAGGUGACACUC AUCAGCGAGUGUC
100 GCUGAUTT ACCUUATT 刺蛋白 2415…2435 47 13459.4
GGUGACACUCGCU AGCAUCAGCGAGU
101 GAUGCUTT GUCACCTT 刺蛋白 2418…2438 58 13489.6
GCAAUAUGGCGAA UAGGCAUUCGCCA
102 UGCCUATT UAUUGCTT 刺蛋白 2448…2468 47 13459.4
UAUGGCGAAUGCC CACCUAGGCAUUC
103 UAGGUGTT GCCAUATT 刺蛋白 2452…2472 53 13474.5
GUUCAAUGGACUU CACUGUAAGUCCA
104 ACAGUGTT UUGAACTT 刺蛋白 2505…2525 42 13444.3
UGGACUUACAGUG UGGCAACACUGUA
105 UUGCCATT AGUCCATT 刺蛋白 2511…2531 47 13459.4
UGGCAUAUAGGUU CCAUUGAACCUAU
106 CAAUGGTT AUGCCATT 刺蛋白 2648…2668 42 13444.3
GCUGCAAGACGUU GUUAACAACGUCU
107 GUUAACTT UGCAGCTT 刺蛋白 2784…2804 47 13459.4
GACGUUGUUAACC CAUUCUGGUUAAC
108 AGAAUGTT AACGUCTT 刺蛋白 2791…2811 42 13444.3
CCAGAAUGCUCAA UAAUGCUUGAGCA
109 GCAUUATT UUCUGGTT 刺蛋白 2802…2822 42 13444.3
UGAUAUCCUUUCG AAGUCGCGAAAGG
110 CGACUUTT AUAUCATT 刺蛋白 2877…2897 42 13444.3
GUCGAGGCGGAGG UUUGUACCUCCGC
111 UACAAATT CUCGACTT 刺蛋白 2902…2922 58 13489.6
UUACAGGCAGACU CUUUGAAGUCUGC
112 UCAAAGTT CUGUAATT 刺蛋白 2933…2953 42 13444.3
GCCUUCAAACCUA GUUACAUAGGUUU
113 UGUAACTT GAAGGCTT 刺蛋白 2951…2971 42 13444.3
UGUCUGAGUGUGU CCAAGAACACACU
114 UCUUGGTT CAGACATT 刺蛋白 3029…3049 47 13459.4
UUUGUCAUGAAGG GCUUUGCCUUCAU
115 CAAAGCTT GACAAATT 刺蛋白 3185…3205 42 13444.3
UUGUGAUGUCGUU GCCAAUAACGACA
116 AUUGGCTT UCACAATT 刺蛋白 3318…3338 42 13444.3
CACAGUUUAUGAU CAGAGGAUCAUAA
117 CCUCUGTT ACUGUGTT 刺蛋白 3348…3368 42 13444.3
CCUGAGCUUGACU UGAAUGAGUCAAG
118 CAUUCATT CUCAGGTT 刺蛋白 3370…3390 47 13459.4
GAAGAGCUGGACA AGUACUUGUCCAG
119 AGUACUTT CUCUUCTT 刺蛋白 3391…3411 47 13459.4
GAGCUGGACAAGU UGAAGUACUUGUC
120 ACUUCATT CAGCUCTT 刺蛋白 3394…3414 47 13459.4
CGCUUCUGUCGUC AAUGUUGACGACA
121 AACAUUTT GAAGCGTT 刺蛋白 3462…3482 47 13459.4
AGAAAUUGACCGC AUUGAGGCGGUCA
122 CUCAAUTT AUUUCUTT 刺蛋白 3486…3506 42 13444.3
GAAAUUGACCGCC CAUUGAGGCGGUC
123 UCAAUGTT AAUUUCTT 刺蛋白 3487…3507 47 13459.4
UUGACCGCCUCAA ACCUCAUUGAGGC
124 UGAGGUTT GGUCAATT 刺蛋白 3491…3511 53 13474.5
UCACUCAUUGACC CUUGAAGGUCAAU
125 UUCAAGTT GAGUGATT 刺蛋白 3529…3549 42 13444.3
UGGCCUUGGUAUG GCCAAACAUACCA
126 UUUGGCTT AGGCCATT 刺蛋白 3577…3597 53 13474.5
UUGCCAUCGUCAU GUAACCAUGACGA
127 GGUUACTT UGGCAATT 刺蛋白 3617…3637 47 13459.4
UCUUGCUUUGUUG GUCAUGCAACAAA
128 CAUGACTT GCAAGATT 刺蛋白 3638…3658 42 13444.3
GUUUGAUGAGGAU AGAGUCAUCCUCA
129 GACUCUTT UCAAACTT 刺蛋白 3708…3728 42 13444.3
以上两表列出的SiRNA可以有效抑制病毒的复制和繁殖,从而起到治疗SARS以及与SARS感染相关的疾病。
SARS病毒的全基因组可分为7个连续的编码区。第一编码区是从核甘酸265到21485,该区段编码两个多功能聚合酶蛋白(a和b);第二编码区是从21492到25259,编码刺蛋白(S蛋白);第三编码区是从25268到26347,编码三种蛋白,包括第一种未知功能蛋白(UP1,25268到26092),第二种未知功能蛋白(UP2,25689到26153),和小分子膜蛋白(E蛋白,26117到26347);第四编码区是从26398到27063,编码膜蛋白(M蛋白);第五编码区是从27074到27265,编码第三种未知功能蛋白(UP3);第六编码区是从27273到27641,编码第四种未知功能蛋白(UP4);第七编码区是从28120到29388,编码核核复合体蛋白(N蛋白,28120到29388)和第五种未知功能蛋白(UP5,28130-28426)。以下表格详细地列出了针对七个编码区的SiRNA分子,表1和2所列的序列未包括在内,它们均为上述核苷酸序列(I)的具体例证。在每一表格中都包括了这些分子的序号、正义链序列、反义链序列、和其分子量(MW)。它们也能起到破坏病毒表达的相应的mRNA分子的效果,因此它们也可用于治疗SARS以及与SARS感染相关的疾病。
表3、针对第一编码区的SiRNA分子,
SiRNA序号 正义链序列 反义链序列 MW
S1 CGAGAAAACACACGUCCAATT UUGGACGUGUGUUUUCUCGTT 13459.4
S2 AACACACGUCCAACUCAGUTT ACUGAGUUGGACGUGUGUUTT 13459.4
S3 ACACACGUCCAACUCAGUUTT AACUGAGUUGGACGUGUGUTT 13459.4
S4 CACACGUCCAACUCAGUUUTT AAACUGAGUUGGACGUGUGTT 13459.4
S5 CUCAGUUUGCCUGUCCUUCTT GAAGGACAGGCAAACUGAGTT 13474.5
S6 GAGGCCCUAUCGGAGGCACTT GUGCCUCCGAUAGGGCCUCTT 13519.8
S7 CACCUCAAAAAUGGCACUUTT AAGUGCCAUUUUUGAGGUGTT 13444.3
S8 AAAUGGCACUUGUGGUCUATT UAGACCACAAGUGCCAUUUTT 13444.3
S9 AAUGGCACUUGUGGUCUAGTT CUAGACCACAAGUGCCAUUTT 13459.4
S10 AUGGCACUUGUGGUCUAGUTT ACUAGACCACAAGUGCCAUTT 13459.4
S11 UGGCACUUGUGGUCUAGUATT UACUAGACCACAAGUGCCATT 13459.4
S12 AAAGGCGUACUGCCCCAGCTT GCUGGGGCAGUACGCCUUUTT 13504.7
S13 AAGGCGUACUGCCCCAGCUTT AGCUGGGGCAGUACGCCUUTT 13504.7
S14 AGGCGUACUGCCCCAGCUUTT AAGCUGGGGCAGUACGCCUTT 13504.7
S15 GGCGUACUGCCCCAGCUUGTT CAAGCUGGGGCAGUACGCCTT 13519.8
S16 CAGCCCUAUGUGUUCAUUATT UAAUGAACACAUAGGGCUGTT 13444.3
S17 ACGUUCUGAUGCCUUAAGCTT GCUUAAGGCAUCAGAACGUTT 13459.4
S18 CGUUCUGAUGCCUUAAGCATT UGCUUAAGGCAUCAGAACGTT 13459.4
S19 GCACCAAUCACGGCCACAATT UUGUGGCCGUGAUUGGUGCTT 13489.6
S20 UCACGGCCACAAGGUCGUUTT AACGACCUUGUGGCCGUGATT 13489.6
S21 GGUCGUUGAGCUGGUUGCATT UGCAACCAGCUCAACGACCTT 13489.6
S22 AUGGACGGCAUUCAGUACGTT CGUACUGAAUGCCGUCCAUTT 13474.5
S23 UGGACGGCAUUCAGUACGGTT CCGUACUGAAUGCCGUCCATT 13489.6
S24 CACUGGGAGUACUCGUGCCTT GGCACGAGUACUCCCAGUGTT 13504.7
S25 ACCCCAAUUGCAUACCGCATT UGCGGUAUGCAAUUGGGGUTT 13474.5
S26 CCCCAAUUGCAUACCGCAATT UUGCGGUAUGCAAUUGGGGTT 13474.5
S27 UUGCAUACCGCAAUGUUCUTT AGAACAUUGCGGUAUGCAATT 13444.3
S28 UGUUCUUCUUCGUAAGAACTT GUUCUUACGAAGAAGAACATT 13429.2
S29 GAACGGUAAUAAGGGAGCCTT GGCUCCCUUAUUACCGUUCTT 13474.5
S30 CGGUAAUAAGGGAGCCGGUTT ACCGGCUCCCUUAUUACCGTT 13489.6
S31 UAAGGGAGCCGGUGGUCAUTT AUGACCACCGGCUCCCUUATT 13489.6
S32 GGGAGCCGGUGGUCAUAGCTT GCUAUGACCACCGGCUCCCTT 13519.8
S33 AGUCUUAUGACUUAGGUGATT UCACCUAAGUCAUAAGACUTT 13429.2
S34 GUCUUAUGACUUAGGUGACTT GUCACCUAAGUCAUAAGACTT 13444.3
S35 GAUUAUGAACAAAACUGGATT UCCAGUUUUGUUCAUAAUCTT 13414.1
S36 CAAAACUGGAACACUAAGCTT GCUUAGUGUUCCAGUUUUGTT 13444.3
S37 AACUGGAACACUAAGCAUGTT CAUGCUUAGUGUUCCAGUUTT 13444.3
S38 ACUGGAACACUAAGCAUGGTT CCAUGCUUAGUGUUCCAGUTT 13459.4
S39 CUGGAACACUAAGCAUGGCTT GCCAUGCUUAGUGUUCCAGTT 13474.5
S40 CACUAAGCAUGGCAGUGGUTT ACCACUGCCAUGCUUAGUGTT 13474.5
S41 GCAUGGCAGUGGUGCACUCTT GAGUGCACCACUGCCAUGCTT 13504.7
S42 CUCACUCGUGAGCUCAAUGTT CAUUGAGCUCACGAGUGAGTT 13474.5
S43 UGGAGGUGCAGUCACUCGCTT GCGAGUGACUGCACCUCCATT 13504.7
S44 CAAUUUCUGUGGCCCAGAUTT AUCUGGGCCACAGAAAUUGTT 13459.4
S45 UUUCUGUGGCCCAGAUGGGTT CCCAUCUGGGCCACAGAAATT 13489.6
S46 AGAUUUUCUCGCACGCGCGTT CGCGCGUGCGAGAAAAUCUTT 13489.6
S47 GAUUUUCUCGCACGCGCGGTT CCGCGCGUGCGAGAAAAUCTT 13504.7
S48 GUCAAUGUGCACUCUUUCCTT GGAAAGAGUGCACAUUGACTT 13459.4
S49 UGUGCACUCUUUCCGAACATT UGUUCGGAAAGAGUGCACATT 13459.4
S50 CAACUUGAUUACAUCGAGUTT ACUCGAUGUAAUCAAGUUGTT 13429.2
S51 CUUGAUUACAUCGAGUCGATT UCGACUCGAUGUAAUCAAGTT 13444.3
S52 GAGAGGUGUCUACUGCUGCTT GCAGCAGUAGACACCUCUCTT 13489.6
S53 AUUGCCUGGUUCACUGAGCTT GCUCAGUGAACCAGGCAAUTT 13474.5
S54 UUGCCUGGUUCACUGAGCGTT CGCUCAGUGAACCAGGCAATT 13489.6
S55 GAGCUACGAGCACCAGACATT UGUCUGGUGCUCGUAGCUCTT 13489.6
S56 AUUAAGAGUGCCAAGAAAUTT AUUUCUUGGCACUCUUAAUTT 13414.1
S57 UUAAGAGUGCCAAGAAAUUTT AAUUUCUUGGCACUCUUAATT 13414.1
S58 GAGUGCCAAGAAAUUUGACTT GUCAAAUUUCUUGGCACUCTT 13444.3
S59 AUUUGACACUUUCAAAGGGTT CCCUUUGAAAGUGUCAAAUTT 13429.2
S60 UUUGACACUUUCAAAGGGGTT CCCCUUUGAAAGUGUCAAATT 13444.3
S61 AGGGGAAUGCCCAAAGUUUTT AAACUUUGGGCAUUCCCCUTT 13459.4
S62 GGGGAAUGCCCAAAGUUUGTT CAAACUUUGGGCAUUCCCCTT 13474.5
S63 UGCCCAAAGUUUGUGUUUCTT GAAACACAAACUUUGGGCATT 13444.3
S64 AGUUUGUGUUUCCUCUUAATT UUAAGAGGAAACACAAACUTT 13414.1
S65 GUUUGUGUUUCCUCUUAACTT GUUAAGAGGAAACACAAACTT 13429.2
S66 CUCAAAAGUCAAAGUCAUUTT AAUGACUUUGACUUUUGAGTT 13414.1
S67 AAGUCAAAGUCAUUCAACCTT GGUUGAAUGACUUUGACUUTT 13429.2
S68 AGUCAAAGUCAUUCAACCATT UGGUUGAAUGACUUUGACUTT 13429.2
S69 GUCAAAGUCAUUCAACCACTT GUGGUUGAAUGACUUUGACTT 13444.3
S70 AGUCAUUCAACCACGUGUUTT AACACGUGGUUGAAUGACUTT 13444.3
S71 GUCAUUCAACCACGUGUUGTT CAACACGUGGUUGAAUGACTT 13459.4
S72 CCACGUGUUGAAAAGAAAATT UUUUCUUUUCAACACGUGGTT 13429.2
S73 AAGAAAAAGACUGAGGGUUTT AACCCUCAGUCUUUUUCUUTT 13429.2
S74 AGAAAAAGACUGAGGGUUUTT AAACCCUCAGUCUUUUUCUTT 13429.2
S75 GAAAAAGACUGAGGGUUUCTT GAAACCCUCAGUCUUUUUCTT 13444.3
S76 AAAGACUGAGGGUUUCAUGTT CAUGAAACCCUCAGUCUUUTT 13444.3
S77 AAGACUGAGGGUUUCAUGGTT CCAUGAAACCCUCAGUCUUTT 13459.4
S78 AGACUGAGGGUUUCAUGGGTT CCCAUGAAACCCUCAGUCUTT 13474.5
S79 GACUGAGGGUUUCAUGGGGTT CCCCAUGAAACCCUCAGUCTT 13489.6
S80 CAAUAUGCACUUGUCUACCTT GGUAGACAAGUGCAUAUUGTT 13444.3
S81 UAUGCACUUGUCUACCUUGTT CAAGGUAGACAAGUGCAUATT 13444.3
S82 AUGUAAUCAUUGCGAUGAATT UUCAUCGCAAUGAUUACAUTT 13414.1
S83 UGUAAUCAUUGCGAUGAAGTT CUUCAUCGCAAUGAUUACATT 13429.2
S84 UCAUUGCGAUGAAGUUUCATT UGAAACUUCAUCGCAAUGATT 13429.2
S85 GUUUCAUGGCAGACGUGCGTT CGCACGUCUGCCAUGAAACTT 13489.6
S86 AGCCACUUGUGAACAUUGUTT ACAAUGUUCACAAGUGGCUTT 13444.3
S87 GCCACUUGUGAACAUUGUGTT CACAAUGUUCACAAGUGGCTT 13459.4
S88 CAUUGUGGCACUGAAAAUUTT AAUUUUCAGUGCCACAAUGTT 13429.2
S89 AUUUAGUUAUUGAAGGACCTT GGUCCUUCAAUAACUAAAUTT 13414.1
S90 UUUAGUUAUUGAAGGACCUTT AGGUCCUUCAAUAACUAAATT 13414.1
S91 GGACCUACUACAUGUGGGUTT ACCCACAUGUAGUAGGUCCTT 13474.5
S92 UGCUGUAGUGAAAAUGCCATT UGGCAUUUUCACUACAGCATT 13444.3
S93 AAUGCCAUGUCCUGCCUGUTT ACAGGCAGGACAUGGCAUUTT 13474.5
S94 AUGCCAUGUCCUGCCUGUCTT GACAGGCAGGACAUGGCAUTT 13489.6
S95 UGCCAUGUCCUGCCUGUCATT UGACAGGCAGGACAUGGCATT 13489.6
S96 GACCCAGAGAUUGGACCUGTT CAGGUCCAAUCUCUGGGUCTT 13489.6
S97 CCACUCAAACAUUGAAACUTT AGUUUCAAUGUUUGAGUGGTT 13429.2
S98 ACAUUGAAACUCGACUCCGTT CGGAGUCGAGUUUCAAUGUTT 13459.4
S99 CAUUGAAACUCGACUCCGCTT GCGGAGUCGAGUUUCAAUGTT 13474.5
S100 ACUCGACUCCGCAAGGGAGTT CUCCCUUGCGGAGUCGAGUTT 13504.7
S101 CUCGACUCCGCAAGGGAGGTT CCUCCCUUGCGGAGUCGAGTT 13519.8
S102 GGGAGGUAGGACUAGAUGUTT ACAUCUAGUCCUACCUCCCTT 13474.5
S103 UAAGCGUGCCUACUGGGUUTT AACCCAGUAGGCACGCUUATT 13474.5
S104 GCGUGCCUACUGGGUUCCUTT AGGAACCCAGUAGGCACGCTT 13504.7
S105 UGUGGAGACCUUGAAUGAGTT CUCAUUCAAGGUCUCCACATT 13459.4
S106 UGAGGAUCUCCUUGAGAUATT UAUCUCAAGGAGAUCCUCATT 13444.3
S107 CGUGUUAACAUUAACAUUGTT CAAUGUUAAUGUUAACACGTT 13414.1
S108 CAUUAACAUUGUUGGCGAUTT AUCGCCAACAAUGUUAAUGTT 13429.2
S109 CAUUGUUGGCGAUUUUCAUTT AUGAAAAUCGCCAACAAUGTT 13429.2
S110 UGAAGAGGUUGCCAUCAUUTT AAUGAUGGCAACCUCUUCATT 13444.3
S111 GAGGUUGCCAUCAUUUUGGTT CCAAAAUGAUGGCAACCUCTT 13459.4
S112 GUGCCUUUAUUGACACUAUTT AUAGUGUCAAUAAAGGCACTT 13429.2
S113 AGAGUCUUGAUUACAAGUCTT GACUUGUAAUCAAGACUCUTT 13429.2
S114 GAGUCUUGAUUACAAGUCUTT AGACUUGUAAUCAAGACUCTT 13429.2
S115 GUCUUUCAAAACCAUUGUUTT AACAAUGGUUUUGAAAGACTT 13414.1
S116 AACCAUUGUUGAGUCCUGCTT GCAGGACUCAACAAUGGUUTT 13459.4
S117 ACCAUUGUUGAGUCCUGCGTT CGCAGGACUCAACAAUGGUTT 13474.5
S118 CCAUUGUUGAGUCCUGCGGTT CCGCAGGACUCAACAAUGGTT 13489.6
S119 CUAUAAAGUUACCAAGGGATT UCCCUUGGUAACUUUAUAGTT 13429.2
S120 AGUUACCAAGGGAAAGCCCTT GGGCUUUCCCUUGGUAACUTT 13474.5
S121 GUUACCAAGGGAAAGCCCGTT CGGGCUUUCCCUUGGUAACTT 13489.6
S122 GGGAAAGCCCGUAAAAGGUTT ACCUUUUACGGGCUUUCCCTT 13474.5
S123 AGCCCGUAAAAGGUGCUUGTT CAAGCACCUUUUACGGGCUTT 13474.5
S124 GCCCGUAAAAGGUGCUUGGTT CCAAGCACCUUUUACGGGCTT 13489.6
S125 AAGGUGCUUGGAACAUUGGTT CCAAUGUUCCAAGCACCUUTT 13459.4
S126 AGGUGCUUGGAACAUUGGATT UCCAAUGUUCCAAGCACCUTT 13459.4
S127 GGUGCUUGGAACAUUGGACTT GUCCAAUGUUCCAAGCACCTT 13474.5
S128 CAUUGGACAACAGAGAUCATT UGAUCUCUGUUGUCCAAUGTT 13444.3
S129 CAGAGAUCAGUUUUAACACTT GUGUUAAAACUGAUCUCUGTT 13429.2
S130 CACCACUGUGUGGUUUUCCTT GGAAAACCACACAGUGGUGTT 13474.5
S131 UUUUUGCGCGCACACUUGATT UCAAGUGUGCGCGCAAAAATT 13459.4
S132 ACCACUCAAUUCCUGAUUUTT AAAUCAGGAAUUGAGUGGUTT 13429.2
S133 CCACUCAAUUCCUGAUUUGTT CAAAUCAGGAAUUGAGUGGTT 13444.3
S134 UUCCUGAUUUGCAAAGAGCTT GCUCUUUGCAAAUCAGGAATT 13444.3
S135 AGAGCAGCUGUCACCAUACTT GUAUGGUGACAGCUGCUCUTT 13474.5
S136 GAGCAGCUGUCACCAUACUTT AGUAUGGUGACAGCUGCUCTT 13474.5
S137 CAGUCAUUACGUCUUGUCGTT CGACAAGACGUAAUGACUGTT 13459.4
S138 CAGUGUCAUUAUUAUGGCATT UGCCAUAAUAAUGACACUGTT 13429.2
S139 CUGGUGGUCUUGUACAACATT UGUUGUACAAGACCACCAGTT 13459.4
S140 CAGACUUCUCAGUGGUUGUTT ACAACCACUGAGAAGUCUGTT 13459.4
S141 UCUUUUGGGCACUACUGUUTT AACAGUAGUGCCCAAAAGATT 13444.3
S142 AAACUCAGGCCUAUCUUUGTT CAAAGAUAGGCCUGAGUUUTT 13444.3
S143 AACUCAGGCCUAUCUUUGATT UCAAAGAUAGGCCUGAGUUTT 13444.3
S144 ACUCAGGCCUAUCUUUGAATT UUCAAAGAUAGGCCUGAGUTT 13444.3
S145 CUCAGGCCUAUCUUUGAAUTT AUUCAAAGAUAGGCCUGAGTT 13444.3
S146 UGGAUUGAGGCGAAACUUATT UAAGUUUCGCCUCAAUCCATT 13444.3
S147 ACUUAGUGCAGGAGUUGAATT UUCAACUCCUGCACUAAGUTT 13444.3
S148 CUUAGUGCAGGAGUUGAAUTT AUUCAACUCCUGCACUAAGTT 13444.3
S149 UUUCUCAAGGAUGCUUGGGTT CCCAAGCAUCCUUGAGAAATT 13459.4
S150 GGAUGCUUGGGAGAUUCUCTT GAGAAUCUCCCAAGCAUCCTT 13474.5
S151 AUUUCUCAUUACAGGUGUUTT AACACCUGUAAUGAGAAAUTT 13414.1
S152 UUUCUCAUUACAGGUGUUUTT AAACACCUGUAAUGAGAAATT 13414.1
S153 GGGUCAAAUACAGGUUGCUTT AGCAACCUGUAUUUGACCCTT 13459.4
S154 AUACAGGUUGCUUCAGAUATT UAUCUGAAGCAACCUGUAUTT 13429.2
S155 UACAGGUUGCUUCAGAUAATT UUAUCUGAAGCAACCUGUATT 13429.2
S156 CAUCAAGGAUUGUGUAAAATT UUUUACACAAUCCUUGAUGTT 13414.1
S157 GGAUUGUGUAAAAUGCUUCTT GAAGCAUUUUACACAAUCCTT 13429.2
S158 AAUGCUUCAUUGAUGUUGUTT ACAACAUCAAUGAAGCAUUTT 13414.1
S159 AUGCUUCAUUGAUGUUGUUTT AACAACAUCAAUGAAGCAUTT 13414.1
S160 UGCUUCAUUGAUGUUGUUATT UAACAACAUCAAUGAAGCATT 13414.1
S161 CAAGGCACUCGAAAUGUGCTT GCACAUUUCGAGUGCCUUGTT 13474.5
S162 GGCACUCGAAAUGUGCAUUTT AAUGCACAUUUCGAGUGCCTT 13459.4
S163 AUGUGCAUUGAUCAAGUCATT UGACUUGAUCAAUGCACAUTT 13429.2
S164 UGUGCAUUGAUCAAGUCACTT GUGACUUGAUCAAUGCACATT 13444.3
S165 GUCACUAUCGCUGGCGCAATT UUGCGCCAGCGAUAGUGACTT 13489.6
S166 AGUUGCGAUCACUCAACUUTT AAGUUGAGUGAUCGCAACUTT 13444.3
S167 GUUGCGAUCACUCAACUUATT UAAGUUGAGUGAUCGCAACTT 13444.3
S168 CUUAGGUGAAGUCUUCAUCTT GAUGAAGACUUCACCUAAGTT 13444.3
S169 GUCUUCAUCGCUCAAAGCATT UGCUUUGAGCGAUGAAGACTT 13459.4
S170 AGCAAGGGACUUUACCGUCTT GACGGUAAAGUCCCUUGCUTT 13474.5
S171 GCAAGGGACUUUACCGUCATT UGACGGUAAAGUCCCUUGCTT 13474.5
S172 GGGACUUUACCGUCAGUGUTT ACACUGACGGUAAAGUCCCTT 13474.5
S173 GGAGCAGCUGCAACUACUCTT GAGUAGUUGCAGCUGCUCCTT 13489.6
S174 CUACUCAUGCCUCUUAAGGTT CCUUAAGAGGCAUGAGUAGTT 13459.4
S175 GGCACCAAAAGAAGUAACCTT GGUUACUUCUUUUGGUGCCTT 13459.4
S176 AAGAAGUAACCUUUCUUGATT UCAAGAAAGGUUACUUCUUTT 13414.1
S177 AGAAGUAACCUUUCUUGAATT UUCAAGAAAGGUUACUUCUTT 13414.1
S178 GAAGUAACCUUUCUUGAAGTT CUUCAAGAAAGGUUACUUCTT 13429.2
S179 GUAACCUUUCUUGAAGGUGTT CACCUUCAAGAAAGGUUACTT 13444.3
S180 CCUUUCUUGAAGGUGAUUCTT GAAUCACCUUCAAGAAAGGTT 13444.3
S181 GGUGAUUCACAUGACACAGTT CUGUGUCAUGUGAAUCACCTT 13459.4
S182 GAACGGUGAACUCGAAGCATT UGCUUCGAGUUCACCGUUCTT 13474.5
S183 CGGUGAACUCGAAGCACUCTT GAGUGCUUCGAGUUCACCGTT 13489.6
S184 CUCGAAGCACUCGAGACGCTT GCGUCUCGAGUGCUUCGAGTT 13504.7
S185 GCACUCGAGACGCCCGUUGTT CAACGGGCGUCUCGAGUGCTT 13519.8
S186 AUGGAGCUAUCGUCGGCACTT GUGCCGACGAUAGCUCCAUTT 13489.6
S187 UGGAGCUAUCGUCGGCACATT UGUGCCGACGAUAGCUCCATT 13489.6
S188 AUGGCCUCAUGCUCUUAGATT UCUAAGAGCAUGAGGCCAUTT 13459.4
S189 UGGCCUCAUGCUCUUAGAGTT CUCUAAGAGCAUGAGGCCATT 13474.5
S190 GGACAAAGAACAAUACUGCTT GCAGUAUUGUUCUUUGUCCTT 13444.3
S191 AGAACAAUACUGCGCAUUGTT CAAUGCGCAGUAUUGUUCUTT 13444.3
S192 GAACAAUACUGCGCAUUGUTT ACAAUGCGCAGUAUUGUUCTT 13444.3
S193 CAAUACUGCGCAUUGUCUCTT GAGACAAUGCGCAGUAUUGTT 13459.4
S194 UACUGCGCAUUGUCUCCUGTT CAGGAGACAAUGCGCAGUATT 13474.5
S195 ACAAUGUCUUUCGCUUAAATT UUUAAGCGAAAGACAUUGUTT 13414.1
S196 CAAUGUCUUUCGCUUAAAATT UUUUAAGCGAAAGACAUUGTT 13414.1
S197 UGUCUUUCGCUUAAAAGGGTT CCCUUUUAAGCGAAAGACATT 13444.3
S198 AAGGGGGUGCACCAAUUAATT UUAAUUGGUGCACCCCCUUTT 13459.4
S199 AGGGGGUGCACCAAUUAAATT UUUAAUUGGUGCACCCCCUTT 13459.4
S200 GGGGGUGCACCAAUUAAAGTT CUUUAAUUGGUGCACCCCCTT 13474.5
S201 UUAAAGGUGUAACCUUUGGTT CCAAAGGUUACACCUUUAATT 13429.2
S202 AGGUGUAACCUUUGGAGAATT UUCUCCAAAGGUUACACCUTT 13444.3
S203 GGUGUAACCUUUGGAGAAGTT CUUCUCCAAAGGUUACACCTT 13459.4
S204 CCUUUGGAGAAGAUACUGUTT ACAGUAUCUUCUCCAAAGGTT 13444.3
S205 GAUACUGUUUGGGAAGUUCTT GAACUUCCCAAACAGUAUCTT 13444.3
S206 GUUCAAGGUUACAAGAAUGTT CAUUCUUGUAACCUUGAACTT 13429.2
S207 GGUUACAAGAAUGUGAGAATT UUCUCACAUUCUUGUAACCTT 13429.2
S208 GAAUGUGAGAAUCACAUUUTT AAAUGUGAUUCUCACAUUCTT 13414.1
S209 UGUGAGAAUCACAUUUGAGTT CUCAAAUGUGAUUCUCACATT 13429.2
S210 UCACAUUUGAGCUUGAUGATT UCAUCAAGCUCAAAUGUGATT 13429.2
S211 CGUGUUGACAAAGUGCUUATT UAAGCACUUUGUCAACACGTT 13444.3
S212 AGUGCUUAAUGAAAAGUGCTT GCACUUUUCAUUAAGCACUTT 13429.2
S213 GUGCUUAAUGAAAAGUGCUTT AGCACUUUUCAUUAAGCACTT 13429.2
S214 UGAAAAGUGCUCUGUCUACTT GUAGACAGAGCACUUUUCATT 13444.3
S215 AAGUGCUCUGUCUACACUGTT CAGUGUAGACAGAGCACUUTT 13459.4
S216 AGUGCUCUGUCUACACUGUTT ACAGUGUAGACAGAGCACUTT 13459.4
S217 GUGCUCUGUCUACACUGUUTT AACAGUGUAGACAGAGCACTT 13459.4
S218 UCCGGUACCGAAGUUACUGTT CAGUAACUUCGGUACCGGATT 13474.5
S219 GUUACUGAGUUUGCAUGUGTT CACAUGCAAACUCAGUAACTT 13444.3
S220 GACUUUACAACCAGUUUCUTT AGAAACUGGUUGUAAAGUCTT 13429.2
S221 CCAGUUUCUGAUCUCCUUATT UAAGGAGAUCAGAAACUGGTT 13444.3
S222 CAUGGGUAUUGAUCUUGAUTT AUCAAGAUCAAUACCCAUGTT 13429.2
S223 GAAAACUUUUCAUCACGUATT UACGUGAUGAAAAGUUUUCTT 13414.1
S224 AACUUUUCAUCACGUAUGUTT ACAUACGUGAUGAAAAGUUTT 13414.1
S225 ACUUUUCAUCACGUAUGUATT UACAUACGUGAUGAAAAGUTT 13414.1
S226 CUUUUCAUCACGUAUGUAUTT AUACAUACGUGAUGAAAAGTT 13414.1
S227 GAAGAGGACGAUGCAGAGUTT ACUCUGCAUCGUCCUCUUCTT 13474.5
S228 GAGGACGAUGCAGAGUGUGTT CACACUCUGCAUCGUCCUCTT 13489.6
S229 GAAGAAAUUGAUGAAACCUTT AGGUUUCAUCAAUUUCUUCTT 13414.1
S230 GAAAUUGAUGAAACCUGUGTT CACAGGUUUCAUCAAUUUCTT 13429.2
S231 AUUGAUGAAACCUGUGAACTT GUUCACAGGUUUCAUCAAUTT 13429.2
S232 UUGAUGAAACCUGUGAACATT UGUUCACAGGUUUCAUCAATT 13429.2
S233 ACCUGUGAACAUGAGUACGTT CGUACUCAUGUUCACAGGUTT 13459.4
S234 CCUGUGAACAUGAGUACGGTT CCGUACUCAUGUUCACAGGTT 13474.5
S235 CAUGAGUACGGUACAGAGGTT CCUCUGUACCGUACUCAUGTT 13474.5
S236 GGUCUCCCUCUGGAAUUUGTT CAAAUUCCAGAGGGAGACCTT 13474.5
S237 UUUGGUGCCUCAGCUGAAATT UUUCAGCUGAGGCACCAAATT 13459.4
S238 ACAGUUCGAGUUGAGGAAGTT CUUCCUCAACUCGAACUGUTT 13459.4
S239 CAGUUCGAGUUGAGGAAGATT UCUUCCUCAACUCGAACUGTT 13459.4
S240 GAAGAAGAGGAAGACUGGCTT GCCAGUCUUCCUCUUCUUCTT 13474.5
S241 GAAGAGGAAGACUGGCUGGTT CCAGCCAGUCUUCCUCUUCTT 13489.6
S242 GAGGAAGACUGGCUGGAUGTT CAUCCAGCCAGUCUUCCUCTT 13489.6
S243 GACUGGCUGGAUGAUACUATT UAGUAUCAUCCAGCCAGUCTT 13459.4
S244 UCAGAGAUUGAGCCAGAACTT GUUCUGGCUCAAUCUCUGATT 13459.4
S245 CCAGAACCUACACCUGAAGTT CUUCAGGUGUAGGUUCUGGTT 13474.5
S246 CCUACACCUGAAGAACCAGTT CUGGUUCUUCAGGUGUAGGTT 13474.5
S247 GAACCAGUUAAUCAGUUUATT UAAACUGAUUAACUGGUUCTT 13414.1
S248 CCAGUUAAUCAGUUUACUGTT CAGUAAACUGAUUAACUGGTT 13429.2
S249 AACUUACUGACAAUGUUGCTT GCAACAUUGUCAGUAAGUUTT 13429.2
S250 ACUUACUGACAAUGUUGCCTT GGCAACAUUGUCAGUAAGUTT 13444.3
S251 CUUACUGACAAUGUUGCCATT UGGCAACAUUGUCAGUAAGTT 13444.3
S252 UGUUGCCAUUAAAUGUGUUTT AACACAUUUAAUGGCAACATT 13414.1
S253 AUGUGUUGACAUCGUUAAGTT CUUAACGAUGUCAACACAUTT 13429.2
S254 UGUGUUGACAUCGUUAAGGTT CCUUAACGAUGUCAACACATT 13444.3
S255 GGAGGCACAAAGUGCUAAUTT AUUAGCACUUUGUGCCUCCTT 13459.4
S256 AGUGCUAAUCCUAUGGUGATT UCACCAUAGGAUUAGCACUTT 13444.3
S257 GUGCUAAUCCUAUGGUGAUTT AUCACCAUAGGAUUAGCACTT 13444.3
S258 UCCUAUGGUGAUUGUAAAUTT AUUUACAAUCACCAUAGGATT 13414.1
S259 AUGCUGCUAACAUACACCUTT AGGUGUAUGUUAGCAGCAUTT 13444.3
S260 UGCUGCUAACAUACACCUGTT CAGGUGUAUGUUAGCAGCATT 13459.4
S261 CAUACACCUGAAACAUGGUTT ACCAUGUUUCAGGUGUAUGTT 13444.3
S262 ACAUGGUGGUGGUGUAGCATT UGCUACACCACCACCAUGUTT 13474.5
S263 CAUGGUGGUGGUGUAGCAGTT CUGCUACACCACCACCAUGTT 13489.6
S264 CAAGGCAACCAAUGGUGCCTT GGCACCAUUGGUUGCCUUGTT 13489.6
S265 GGCAACCAAUGGUGCCAUGTT CAUGGCACCAUUGGUUGCCTT 13489.6
S266 CCAAUGGUGCCAUGCAAAATT UUUUGCAUGGCACCAUUGGTT 13459.4
S267 UGGUGCCAUGCAAAAGGAGTT CUCCUUUUGCAUGGCACCATT 13474.5
S268 AAGGAGAGUGAUGAUUACATT UGUAAUCAUCACUCUCCUUTT 13429.2
S269 AGGAGAGUGAUGAUUACAUTT AUGUAAUCAUCACUCUCCUTT 13429.2
S270 GGAGAGUGAUGAUUACAUUTT AAUGUAAUCAUCACUCUCCTT 13429.2
S271 GCUAAAUGGCCCUCUUACATT UGUAAGAGGGCCAUUUAGCTT 13459.4
S272 AUGGCCCUCUUACAGUAGGTT CCUACUGUAAGAGGGCCAUTT 13474.5
S273 UGGCCCUCUUACAGUAGGATT UCCUACUGUAAGAGGGCCATT 13474.5
S274 UCUUGCUAAGAAGUGUCUGTT CAGACACUUCUUAGCAAGATT 13444.3
S275 GAAGUGUCUGCAUGUUGUUTT AACAACAUGCAGACACUUCTT 13444.3
S276 GUGUCUGCAUGUUGUUGGATT UCCAACAACAUGCAGACACTT 13459.4
S277 CCUAAAUGCAGGUGAGGACTT GUCCUCACCUGCAUUUAGGTT 13474.5
S278 AUGCAGGUGAGGACAUCCATT UGGAUGUCCUCACCUGCAUTT 13474.5
S279 UGCAGGUGAGGACAUCCAGTT CUGGAUGUCCUCACCUGCATT 13489.6
S280 GGCAGCAUAUGAAAAUUUCTT GAAAUUUUCAUAUGCUGCCTT 13429.2
S281 AAUUUCAAUUCACAGGACATT UGUCCUGUGAAUUGAAAUUTT 13414.1
S282 AUUUCAAUUCACAGGACAUTT AUGUCCUGUGAAUUGAAAUTT 13414.1
S283 UUUCAAUUCACAGGACAUCTT GAUGUCCUGUGAAUUGAAATT 13429.2
S284 UUCACAGGACAUCUUACUUTT AAGUAAGAUGUCCUGUGAATT 13429.2
S285 ACCACUUCAGUCUUUACAATT UUGUAAAGACUGAAGUGGUTT 13429.2
S286 GUGUGCGUGCAGACGGUUCTT GAACCGUCUGCACGCACACTT 13504.7
S287 UGACAAAGCUCUUUAUGAGTT CUCAUAAAGAGCUUUGUCATT 13429.2
S288 AGCUCUUUAUGAGCAGGUUTT AACCUGCUCAUAAAGAGCUTT 13444.3
S289 GCUCUUUAUGAGCAGGUUGTT CAACCUGCUCAUAAAGAGCTT 13459.4
S290 CCUGAAGCCUAGAGUGGAATT UUCCACUCUAGGCUUCAGGTT 13474.5
S291 GCCUAGAGUGGAAGCACCUTT AGGUGCUUCCACUCUAGGCTT 13489.6
S292 GCACCUAAACAAGAGGAGCTT GCUCCUCUUGUUUAGGUGCTT 13474.5
S293 ACAAGAGGAGCCACCAAACTT GUUUGGUGGCUCCUCUUGUTT 13474.5
S294 CAAGAGGAGCCACCAAACATT UGUUUGGUGGCUCCUCUUGTT 13474.5
S295 GAGGAGCCACCAAACACAGTT CUGUGUUUGGUGGCUCCUCTT 13489.6
S296 ACACAGAAGAUUCCAAAACTT GUUUUGGAAUCUUCUGUGUTT 13429.2
S297 CACAGAAGAUUCCAAAACUTT AGUUUUGGAAUCUUCUGUGTT 13429.2
S298 GAUUCCAAAACUGAGGAGATT UCUCCUCAGUUUUGGAAUCTT 13444.3
S299 AACUGAGGAGAAAUCUGUCTT GACAGAUUUCUCCUCAGUUTT 13444.3
S300 ACUGAGGAGAAAUCUGUCGTT CGACAGAUUUCUCCUCAGUTT 13459.4
S301 CUGAGGAGAAAUCUGUCGUTT ACGACAGAUUUCUCCUCAGTT 13459.4
S302 AUCUGUCGUACAGAAGCCUTT AGGCUUCUGUACGACAGAUTT 13459.4
S303 UCUGUCGUACAGAAGCCUGTT CAGGCUUCUGUACGACAGATT 13474.5
S304 GCCUGUCGAUGUGAAGCCATT UGGCUUCACAUCGACAGGCTT 13489.6
S305 GCCAAAAAUUAAGGCCUGCTT GCAGGCCUUAAUUUUUGGCTT 13459.4
S306 AAAUUAAGGCCUGCAUUGATT UCAAUGCAGGCCUUAAUUUTT 13429.2
S307 AAUUAAGGCCUGCAUUGAUTT AUCAAUGGAGGCCUUAAUUTT 13429.2
S308 AUUAAGGCCUGCAUUGAUGTT CAUCAAUGCAGGCCUUAAUTT 13444.3
S309 UUAAGGCCUGCAUUGAUGATT UCAUCAAUGCAGGCCUUAATT 13444.3
S310 GGCCUGCAUUGAUGAGGUUTT AACCUCAUCAAUGCAGGCCTT 13474.5
S311 CACUGGAAGAAACUAAGUUTT AACUUAGUUUCUUCCAGUGTT 13429.2
S312 GAAACUAAGUUUCUUACCATT UGGUAAGAAACUUAGUUUCTT 13414.1
S313 UAAGUUACUCUUGUUUGCUTT AGCAAACAAGAGUAACUUATT 13414.1
S314 GUUACUCUUGUUUGCUGAUTT AUCAGCAAACAAGAGUAACTT 13429.2
S315 UGGUAAGCUUUACCAUGAUTT AUCAUGGUAAAGCUUACCATT 13429.2
S316 GCUUUACCAUGAUUCUCAGTT CUGAGAAUCAUGGUAAAGCTT 13444.3
S317 CAUGCUUAGAGGUGAAGAUTT AUCUUCACCUCUAAGCAUGTT 13444.3
S318 GAUAUGUCUUUCCUUGAGATT UCUCAAGGAAAGACAUAUCTT 13429.2
S319 GGAUGCACCUUACAUGGUATT UACCAUGUAAGGUGCAUCCTT 13459.4
S320 UACCCUCCAAAAAGGCUGGTT CCAGCCUUUUUGGAGGGUATT 13474.5
S321 AAAGGCUGGUGGCACUACUTT AGUAGUGCCACCAGCCUUUTT 13474.5
S322 AAGGCUGGUGGCACUACUGTT CAGUAGUGCCACCAGCCUUTT 13489.6
S323 AGGCUGGUGGCACUACUGATT UCAGUAGUGCCACCAGCCUTT 13489.6
S324 GGCUGGUGGCACUACUGAGTT CUCAGUAGUGCCACCAGCCTT 13504.7
S325 GAGCUUUGAAGAAAGUGCCTT GGCACUUUCUUCAAAGCUCTT 13459.4
S326 AGUGCCAGUUGAUGAGUAUTT AUACUCAUCAACUGGCACUTT 13444.3
S327 GUGCCAGUUGAUGAGUAUATT UAUACUCAUCAACUGGCACTT 13444.3
S328 CCACGUACCCUGGACAAGGTT CCUUGUCCAGGGUACGUGGTT 13504.7
S329 GGAUGUGCUGGUUAUACACTT GUGUAUAACCAGCACAUCCTT 13459.4
S330 GCUAAGACUGCUCUUAAGATT UCUUAAGAGCAGUCUUAGCTT 13444.3
S331 GACUGCUCUUAAGAAAUGCTT GCAUUUCUUAAGAGCAGUCTT 13444.3
S332 GAAAUGCAAAUCUGCAUUUTT AAAUGCAGAUUUGCAUUUCTT 13414.1
S333 UGCAAAUCUGCAUUUUAUGTT CAUAAAAUGCAGAUUUGCATT 13414.1
S334 UCUGCAUUUUAUGUACUACTT GUAGUACAUAAAAUGCAGATT 13414.1
S335 GCACCUAAUGCUAAGGAAGTT CUUCCUUAGCAUUAGGUGCTT 13459.4
S336 UGCUAAGGAAGAGAUUCUATT UAGAAUCUCUUCCUUAGCATT 13429.2
S337 GGAAGAGAUUCUAGGAACUTT AGUUCCUAGAAUCUCUUCCTT 13444.3
S338 GAGAUUCUAGGAACUGUAUTT AUACAGUUCCUAGAAUCUCTT 13429.2
S339 CUGUAUCCUGGAAUUUGAGTT CUCAAAUUCCAGGAUACAGTT 13444.3
S340 UUUGAGAGAAAUGCUUGCUTT AGCAAGCAUUUCUCUCAAATT 13429.2
S341 AUGCUUGCUCAUGCUGAAGTT CUUCAGCAUGAGCAAGCAUTT 13459.4
S342 UGCUUGCUCAUGCUGAAGATT UCUUCAGCAUGAGCAAGCATT 13459.4
S343 GAGACAAGAAAAUUAAUGCTT GCAUUAAUUUUCUUGUCUCTT 13414.1
S344 AUUAAUGCCUAUAUGCAUGTT CAUGCAUAUAGGCAUUAAUTT 13414.1
S345 UUAAUGCCUAUAUGCAUGGTT CCAUGCAUAUAGGCAUUAATT 13429.2
S346 UGCCUAUAUGCAUGGAUGUTT ACAUCCAUGCAUAUAGGCATT 13444.3
S347 UGGCAACCAUCCAACGUAATT UUACGUUGGAUGGUUGCCATT 13459.4
S348 CCAUCCAACGUAAGUAUAATT UUAUACUUACGUUGGAUGGTT 13429.2
S349 GGAAUUAAAAUUCAAGAGGTT CCUCUUGAAUUUUAAUUCCTT 13414.1
S350 UUAAAAUUCAAGAGGGCAUTT AUGCCCUCUUGAAUUUUAATT 13414.1
S351 AAUUCAAGAGGGCAUCGUUTT AACGAUGCCCUCUUGAAUUTT 13444.3
S352 AUUCAAGAGGGCAUCGUUGTT CAACGAUGCCCUCUUGAAUTT 13459.4
S353 UUCAAGAGGGCAUCGUUGATT UCAACGAUGCCCUCUUGAATT 13459.4
S354 GAGGGCAUCGUUGACUAUGTT CAUAGUCAACGAUGCCCUCTT 13474.5
S355 AGAGCCUGUAGCUUCUAUUTT AAUAGAAGCUACAGGCUCUTT 13444.3
S356 GAGCCUGUAGCUUCUAUUATT UAAUAGAAGCUACAGGCUCTT 13444.3
S357 GCUGAACUCUCUAAAUGAGTT CUCAUUUAGAGAGUUCAGCTT 13444.3
S358 CUCUCUAAAUGAGCCGCUUTT AAGCGGCUCAUUUAGAGAGTT 13459.4
S359 AUGAGCCGCUUGUCACAAUTT AUUGUGACAAGCGGCUCAUTT 13459.4
S360 UGAGCCGCUUGUCACAAUGTT CAUUGUGACAAGCGGCUCATT 13474.5
S361 UGCCAAUUGGUUAUGUGACTT GUCACAUAACCAAUUGGCATT 13444.3
S362 UUGGUUAUGUGACACAUGGTT CCAUGUGUCACAUAACCAATT 13444.3
S363 UCUUGAAGAGGCUGCGCGCTT GCGCGCAGCCUCUUCAAGATT 13504.7
S364 GAGGCUGCGCGCUGUAUGCTT GCAUACAGCGCGCAGCCUCTT 13519.8
S365 AGCUCCUGCCGUAGUGUCATT UGACACUACGGCAGGAGCUTT 13489.6
S366 GCUCCUGCCGUAGUGUCAGTT CUGACACUACGGCAGGAGCTT 13504.7
S367 UGGAUACCUCACUUCGUCATT UGACGAAGUGAGGUAUCCATT 13459.4
S368 AGACAUCUGAGGAGCACUUTT AAGUGCUCCUCAGAUGUCUTT 13459.4
S369 GACAUCUGAGGAGCACUUUTT AAAGUGCUCCUCAGAUGUCTT 13459.4
S370 ACAGUUUCUUUGGCUGGCUTT AGCCAGCCAAAGAAACUGUTT 13459.4
S371 CAGUUUCUUUGGCUGGCUCTT GAGCCAGCCAAAGAAACUGTT 13474.5
S372 UUUCUUAAGCGUGGUGACATT UGUCACCACGCUUAAGAAATT 13444.3
S373 GCGUGGUGACAAAAUUGUGTT CACAAUUUUGUCACCACGCTT 13459.4
S374 AAUUGUGUACCACACUCUGTT CAGAGUGUGGUACACAAUUTT 13444.3
S375 AUUGUGUACCACACUCUGGTT CCAGAGUGUGGUACACAAUTT 13459.4
S376 UUGUGUACCACACUCUGGATT UCCAGAGUGUGGUACACAATT 13459.4
S377 ACUAAAGAGUCUCUUAUCCTT GGAUAAGAGACUCUUUAGUTT 13429.2
S378 CUAAAGAGUCUCUUAUCCCTT GGGAUAAGAGACUCUUUAGTT 13444.3
S379 AGAGUCUCUUAUCCCUGCGTT CGCAGGGAUAAGAGACUCUTT 13474.5
S380 GAGUCUCUUAUCCCUGCGGTT CCGCAGGGAUAAGAGACUCTT 13489.6
S381 GACUAUAAAAGUGUUCACATT UGUGAACACUUUUAUAGUCTT 13414.1
S382 AAGUGUUCACAACUGUGGATT UCCACAGUUGUGAACACUUTT 13444.3
S383 AGUGUUCACAACUGUGGACTT GUCCACAGUUGUGAACACUTT 13459.4
S384 GUGUUCACAACUGUGGACATT UGUCCACAGUUGUGAACACTT 13459.4
S385 CUGUGGACAACACUAAUCUTT AGAUUAGUGUUGUCCACAGTT 13444.3
S386 CACUAAUCUCCACACACAGTT CUGUGUGUGGAGAUUAGUGTT 13459.4
S387 UCUCCACACACAGCUUGUGTT CACAAGCUGUGUGUGGAGATT 13474.5
S388 CAUACUUGGAUGGUGCUGATT UCAGCACCAUCCAAGUAUGTT 13459.4
S389 ACCUCAUGUAAAUCAUGAGTT CUCAUGAUUUACAUGAGGUTT 13429.2
S390 CCUCAUGUAAAUCAUGAGGTT CCUCAUGAUUUACAUGAGGTT 13444.3
S391 AUCAUGAGGGUAAGACUUUTT AAAGUCUUACCCUCAUGAUTT 13429.2
S392 UCAUGAGGGUAAGACUUUCTT GAAAGUCUUACCCUCAUGATT 13444.3
S393 GACUUUCUUUGUACUACCUTT AGGUAGUACAAAGAAAGUCTT 13429.2
S394 GCUUUCGAGUACUACCAUATT UAUGGUAGUACUCGAAAGCTT 13444.3
S395 CCACACAAAGAAAUGGAAATT UUUCCAUUUCUUUGUGUGGTT 13429.2
S396 AGAAAUGGAAAUUUCCUCATT UGAGGAAAUUUCCAUUUCUTT 13414.1
S397 GAAAUGGAAAUUUCCUCAATT UUGAGGAAAUUUCCAUUUCTT 13414.1
S398 AUGGAAAUUUCCUCAAGUUTT AACUUGAGGAAAUUUCCAUTT 13414.1
S399 UGGAAAUUUCCUCAAGUUGTT CAACUUGAGGAAAUUUCCATT 13429.2
S400 AUUUCCUCAAGUUGGUGGUTT ACCACCAACUUGAGGAAAUTT 13444.3
S401 UUUCCUCAAGUUGGUGGUUTT AACCACCAACUUGAGGAAATT 13444.3
S402 GUUGGUGGUUUAACUUCAATT UUGAAGUUAAACCACCAACTT 13429.2
S403 CUUCAAUUAAAUGGGCUGATT UCAGCCCAUUUAAUUGAAGTT 13429.2
S404 UUAAAUGGGCUGAUAACAATT UUGUUAUCAGCCCAUUUAATT 13414.1
S405 AUGGGCUGAUAACAAUUGUTT ACAAUUGUUAUCAGCCCAUTT 13429.2
S406 UGGGCUGAUAACAAUUGUUTT AACAAUUGUUAUCAGCCCATT 13429.2
S407 CAGCUUGAAGUCAAAUUCATT UGAAUUUGACUUCAAGCUGTT 13429.2
S408 GUCAAAUUCAAUGCACCAGTT CUGGUGCAUUGAAUUUGACTT 13444.3
S409 AUUCAAUGCACCAGCACUUTT AAGUGCUGGUGCAUUGAAUTT 13444.3
S410 UUCAAUGCACCAGCACUUCTT GAAGUGCUGGUGCAUUGAATT 13459.4
S411 UGCACCAGCACUUCAAGAGTT CUCUUGAAGUGCUGGUGCATT 13474.5
S412 GAGGCUUAUUAUAGAGCCCTT GGGCUCUAUAAUAAGCCUCTT 13459.4
S413 CUUUUGUGCACUCAUACUCTT GAGUAUGAGUGCACAAAAGTT 13444.3
S414 UAAAACUGUUGGCGAGCUUTT AAGCUCGCCAACAGUUUUATT 13444.3
S415 AACUGUUGGCGAGCUUGGUTT ACCAAGCUCGCCAACAGUUTT 13474.5
S416 ACUGUUGGCGAGCUUGGUGTT CACCAAGCUCGCCAACAGUTT 13489.6
S417 CUGUUGGCGAGCUUGGUGATT UCACCAAGCUCGCCAACAGTT 13489.6
S418 ACUAUGACCCAUCUUCUACTT GUAGAAGAUGGGUCAUAGUTT 13444.3
S419 CUAUGACCCAUCUUCUACATT UGUAGAAGAUGGGUCAUAGTT 13444.3
S420 UUUGGAAUCUGCAAAGCGATT UCGCUUUGCAGAUUCCAAATT 13444.3
S421 UCUGCAAAGCGAGUUCUUATT UAAGAACUCGCUUUGCAGATT 13444.3
S422 AGCGAGUUCUUAAUGUGGUTT ACCACAUUAAGAACUCGCUTT 13444.3
S423 GCGAGUUCUUAAUGUGGUGTT CACCACAUUAAGAACUCGCTT 13459.4
S424 UGUGGUGUGUAAACAUUGUTT ACAAUGUUUACACACCACATT 13429.2
S425 ACAUUGUGGUCAGAAAACUTT AGUUUUCUGACCACAAUGUTT 13429.2
S426 CAUUGUGGUCAGAAAACUATT UAGUUUUCUGACCACAAUGTT 13429.2
S427 AACUACUACCUUAACGGGUTT ACCCGUUAAGGUAGUAGUUTT 13444.3
S428 ACUACUACCUUAACGGGUGTT CACCCGUUAAGGUAGUAGUTT 13459.4
S429 CUACUACCUUAACGGGUGUTT ACACCCGUUAAGGUAGUAGTT 13459.4
S430 CGGGUGUAGAAGCUGUGAUTT AUCACAGCUUCUACACCCGTT 13474.5
S431 GCUGUGAUGUAUAUGGGUATT UACCCAUAUACAUCACAGCTT 13444.3
S432 UCUUAAGACAGGUGUUUCCTT GGAAACACCUGUCUUAAGATT 13444.3
S433 GACAGGUGUUUCCAUUCCATT UGGAAUGGAAACACCUGUCTT 13459.4
S434 UAUCUAGUACAACAAGAGUTT ACUCUUGUUGUACUAGAUATT 13414.1
S435 CAAGAGUCUUCUUUUGUUATT UAACAAAAGAAGACUCUUGTT 13414.1
S436 GAGUCUUCUUUUGUUAUGATT UCAUAACAAAAGAAGACUCTT 13414.1
S437 AUUACAGCAAGGUACAUUCTT GAAUGUACCUUGCUGUAAUTT 13429.2
S438 UUACAGCAAGGUACAUUCUTT AGAAUGUACCUUGCUGUAATT 13429.2
S439 GGUACAUUCUUAUGUGCGATT UCGCACAUAAGAAUGUACCTT 13444.3
S440 UGAGUACACUGGUAACUAUTT AUAGUUACCAGUGUACUCATT 13429.2
S441 CUAUCAGUGUGGUCAUUACTT GUAAUGACCACACUGAUAGTT 13444.3
S442 CUGCUAAGGAGACCCUCUATT UAGAGGGUCUCCUUAGCAGTT 13474.5
S443 GGAGACCCUCUAUCGUAUUTT AAUACGAUAGAGGGUCUCCTT 13459.4
S444 AGAUGUCAGAGUACAAAGGTT CCUUUGUACUCUGACAUCUTT 13444.3
S445 GAUGUCAGAGUACAAAGGATT UCCUUUGUACUCUGACAUCTT 13444.3
S446 AGGACCAGUGACUGAUGUUTT AACAUCAGUCACUGGUCCUTT 13459.4
S447 GGACCAGUGACUGAUGUUUTT AAACAUCAGUCACUGGUCCTT 13459.4
S448 GGAAACAUCUUACACUACATT UGUAGUGUAAGAUGUUUCCTT 13429.2
S449 ACAUCUUACACUACAACCATT UGGUUGUAGUGUAAGAUGUTT 13429.2
S450 CAUCUUACACUACAACCAUTT AUGGUUGUAGUGUAAGAUGTT 13429.2
S451 CCAUCAAGCCUGUGUCGUATT UACGACACAGGCUUGAUGGTT 13474.5
S452 GCCUGUGUCGUAUAAACUCTT GAGUUUAUACGACACAGGCTT 13459.4
S453 ACUCGAUGGAGUUACUUACTT GUAAGUAACUCCAUCGAGUTT 13444.3
S454 CUCGAUGGAGUUACUUACATT UGUAAGUAACUCCAUCGAGTT 13444.3
S455 CCAAAAUUGGAUGGGUAUUTT AAUACCCAUCCAAUUUUGGTT 13429.2
S456 AGGAUAAUGCUUACUAUACTT GUAUAGUAAGCAUUAUCCUTT 13414.1
S457 GGAUAAUGCUUACUAUACATT UGUAUAGUAAGCAUUAUCCTT 13414.1
S458 UGCUUACUAUACAGAGCAGTT CUGCUCUGUAUAGUAAGCATT 13444.3
S459 CUCAACCAUUACCAAAUGCTT GCAUUUGGUAAUGGUUGAGTT 13444.3
S460 CCAUUACCAAAUGCGAGUUTT AACUCGCAUUUGGUAAUGGTT 13444.3
S461 UGCGAGUUUUGAUAAUUUCTT GAAAUUAUCAAAACUCGCATT 13414.1
S462 UUUCAAACUCACAUGUUCUTT AGAACAUGUGAGUUUGAAATT 13414.1
S463 ACUCACAUGUUCUAACACATT UGUGUUAGAACAUGUGAGUTT 13429.2
S464 CUCACAUGUUCUAACACAATT UUGUGUUAGAACAUGUGAGTT 13429.2
S465 CACAAAAUUUGCUGAUGAUTT AUCAUCAGCAAAUUUUGUGTT 13414.1
S466 AUCAAAUGACAGGCUUCACTT GUGAAGCCUGUCAUUUGAUTT 13444.3
S467 UCAAAUGACAGGCUUCACATT UGUGAAGCCUGUCAUUUGATT 13444.3
S468 AUGACAGGCUUCACAAAGCTT GCUUUGUGAAGCCUGUCAUTT 13459.4
S469 UGACAGGCUUCACAAAGCCTT GGCUUUGUGAAGCCUGUCATT 13474.5
S470 AGCCAGCUUCACGAGAGCUTT AGCUCUCGUGAAGCUGGCUTT 13489.6
S471 GCCAGCUUCACGAGAGCUATT UAGCUCUCGUGAAGCUGGCTT 13489.6
S472 UGGCGAUGUAGUGGCUAUUTT AAUAGCCACUACAUCGCCATT 13459.4
S473 GAAAGGUGCUAAAUUACUGTT CAGUAAUUUAGCACCUUUCTT 13429.2
S474 AGGUGCUAAAUUACUGCAUTT AUGCAGUAAUUUAGCACCUTT 13429.2
S475 GGUGCUAAAUUACUGCAUATT UAUGCAGUAAUUUAGCACCTT 13429.2
S476 AUUACUGCAUAAGCCAAUUTT AAUUGGCUUAUGCAGUAAUTT 13414.1
S477 UUACUGCAUAAGCCAAUUGTT CAAUUGGCUUAUGCAGUAATT 13429.2
S478 GCCAAUUGUUUGGCACAUUTT AAUGUGCCAAACAAUUGGCTT 13444.3
S479 UUGUUUGGCACAUUAACCATT UGGUUAAUGUGCCAAACAATT 13429.2
S480 CCAGGCUACAACCAAGACATT UGUCUUGGUUGUAGCCUGGTT 13474.5
S481 CCAAGACAACGUUCAAACCTT GGUUUGAACGUUGUCUUGGTT 13459.4
S482 GACAACGUUCAAACCAAACTT GUUUGGUUUGAACGUUGUCTT 13444.3
S483 CGUUCAAACCAAACACUUGTT CAAGUGUUUGGUUUGAACGTT 13444.3
S484 ACCAAACACUUGGUGUUUATT UAAACACCAAGUGUUUGGUTT 13429.2
S485 CCAAACACUUGGUGUUUACTT GUAAACACCAAGUGUUUGGTT 13444.3
S486 ACACUUGGUGUUUACGUUGTT CAACGUAAACACCAAGUGUTT 13444.3
S487 CACUUGGUGUUUACGUUGUTT ACAACGUAAACACCAAGUGTT 13444.3
S488 AGCCAGUAGAUACUUCAAATT UUUGAAGUAUCUACUGGCUTT 13429.2
S489 GCCAGUAGAUACUUCAAAUTT AUUUGAAGUAUCUACUGGCTT 13429.2
S490 AUUCAUUUGAAGUUCUGGCTT GCCAGAACUUCAAAUGAAUTT 13429.2
S491 UUCAUUUGAAGUUCUGGCATT UGCCAGAACUUCAAAUGAATT 13429.2
S492 GUUCUGGCAGUAGAAGACATT UGUCUUCUACUGCCAGAACTT 13459.4
S493 GACACACAAGGAAUGGACATT UGUCCAUUCCUUGUGUGUCTT 13459.4
S494 GGAAUGGACAAUCUUGCUUTT AAGCAAGAUUGUCCAUUCCTT 13444.3
S495 UGGACAAUCUUGCUUGUGATT UCACAAGCAAGAUUGUCCATT 13444.3
S496 UCUUGCUUGUGAAAGUCAATT UUGACUUUCACAAGCAAGATT 13429.2
S497 AGUCAACAACCCACCUCUGTT CAGAGGUGGGUUGUUGACUTT 13474.5
S498 GUCAACAACCCACCUCUGATT UCAGAGGUGGGUUGUUGACTT 13474.5
S499 CAACCCACCUCUGAAGAAGTT CUUCUUCAGAGGUGGGUUGTT 13474.5
S500 CCCACCUCUGAAGAAGUAGTT CUACUUCUUCAGAGGUGGGTT 13474.5
S501 GAAGUAGUGGAAAAUCCUATT UAGGAUUUUCCACUACUUCTT 13429.2
S502 GUAGUGGAAAAUCCUACCATT UGGUAGGAUUUUCCACUACTT 13444.3
S503 AAUCCUACCAUACAGAAGGTT CCUUCUGUAUGGUAGGAUUTT 13444.3
S504 AUCCUACCAUACAGAAGGATT UCCUUCUGUAUGGUAGGAUTT 13444.3
S505 UCCUACCAUACAGAAGGAATT UUCCUUCUGUAUGGUAGGATT 13444.3
S506 GGAAGUCAUAGAGUGUGACTT GUCACACUCUAUGACUUCCTT 13459.4
S507 GUCAUAGAGUGUGACGUGATT UCACGUCACACUCUAUGACTT 13459.4
S508 AACUACCGAAGUUGUAGGCTT GCCUACAACUUCGGUAGUUTT 13459.4
S509 ACUACCGAAGUUGUAGGCATT UGCCUACAACUUCGGUAGUTT 13459.4
S510 CUACCGAAGUUGUAGGCAATT UUGCCUACAACUUCGGUAGTT 13459.4
S511 GUUGUAGGCAAUGUCAUACTT GUAUGACAUUGCCUACAACTT 13444.3
S512 UGUCAUACUUAAACCAUCATT UGAUGGUUUAAGUAUGACATT 13414.1
S513 ACCAUCAGAUGAAGGUGUUTT AACACCUUCAUCUGAUGGUTT 13444.3
S514 CCAUCAGAUGAAGGUGUUATT UAACACCUUCAUCUGAUGGTT 13444.3
S515 GGUGUUAAAGUAACACAAGTT CUUGUGUUACUUUAACACCTT 13429.2
S516 AGUAACACAAGAGUUAGGUTT ACCUAACUCUUGUGUUACUTT 13429.2
S517 GUAACACAAGAGUUAGGUCTT GACCUAACUCUUGUGUUACTT 13444.3
S518 CACAAGAGUUAGGUCAUGATT UCAUGACCUAACUCUUGUGTT 13444.3
S519 GAGUUAGGUCAUGAGGAUCTT GAUCCUCAUGACCUAACUCTT 13459.4
S520 AACACAAGCAUUACCAUUATT UAAUGGUAAUGCUUGUGUUTT 13414.1
S521 ACACAAGCAUUACCAUUAATT UUAAUGGUAAUGCUUGUGUTT 13414.1
S522 CACAAGCAUUACCAUUAAGTT CUUAAUGGUAAUGCUUGUGTT 13429.2
S523 GCAUUACCAUUAAGAAACCTT GGUUUCUUAAUGGUAAUGCTT 13429.2
S524 GAAACCUAAUGAGCUUUCATT UGAAAGCUCAUUAGGUUUCTT 13429.2
S525 ACCUAAUGAGCUUUCACUATT UAGUGAAAGCUCAUUAGGUTT 13429.2
S526 CCUAAUGAGCUUUCACUAGTT CUAGUGAAAGCUCAUUAGGTT 13444.3
S527 UGAGCUUUCACUAGCCUUATT UAAGGCUAGUGAAAGCUCATT 13444.3
S528 AAACAAUUGCCACUCAUGGTT CCAUGAGUGGCAAUUGUUUTT 13444.3
S529 AACAAUUGCCACUCAUGGUTT ACCAUGAGUGGCAAUUGUUTT 13444.3
S530 ACAAUUGCCACUCAUGGUATT UACCAUGAGUGGCAAUUGUTT 13444.3
S531 CAAUUGCCACUCAUGGUAUTT AUACCAUGAGUGGCAAUUGTT 13444.3
S532 UUGCCACUCAUGGUAUUGCTT GCAAUACCAUGAGUGGCAATT 13459.4
S533 UUAAUAGUGUUCCUUGGAGTT CUCCAAGGAACACUAUUAATT 13429.2
S534 UAGUGUUCCUUGGAGUAAATT UUUACUCCAAGGAACACUATT 13429.2
S535 AUUUUGGCUUAUGUCAAACTT GUUUGACAUAAGCCAAAAUTT 13414.1
S536 UUUUGGCUUAUGUCAAACCTT GGUUUGACAUAAGCCAAAATT 13429.2
S537 ACCAUUCUUAGGACAAGCATT UGCUUGUCCUAAGAAUGGUTT 13444.3
S538 CCAUUCUUAGGACAAGCAGTT CUGCUUGUCCUAAGAAUGGTT 13459.4
S539 GCAGCAAUUACAACAUCAATT UUGAUGUUGUAAUUGCUGCTT 13429.2
S540 UUACAACAUCAAAUUGCGCTT GCGCAAUUUGAUGUUGUAATT 13429.2
S541 CAUCAAAUUGCGCUAAGAGTT CUCUUAGCGCAAUUUGAUGTT 13444.3
S542 AUUGCGCUAAGAGAUUAGCTT GCUAAUCUCUUAGCGCAAUTT 13444.3
S543 UUGCGCUAAGAGAUUAGCATT UGCUAAUCUCUUAGCGCAATT 13444.3
S544 GAGAUUAGCACAACGUGUGTT CACACGUUGUGCUAAUCUCTT 13459.4
S545 CAAUUAUAUGCCUUAUGUGTT CACAUAAGGCAUAUAAUUGTT 13414.1
S546 GUACCAAUUCUAGAAUUAGTT CUAAUUCUAGAAUUGGUACTT 13414.1
S547 UUCUAGAAUUAGAGCUUCATT UGAAGCUCUAAUUCUAGAATT 13414.1
S548 UUAGAGCUUCACUACCUACTT GUAGGUAGUGAAGCUCUAATT 13444.3
S549 AAUAGUGUUAAGAGUGUUGTT CAACACUCUUAACACUAUUTT 13414.1
S550 AUAGUGUUAAGAGUGUUGCTT GCAACACUCUUAACACUAUTT 13429.2
S551 UAGUGUUAAGAGUGUUGCUTT AGCAACACUCUUAACACUATT 13429.2
S552 GAGUGUUGCUAAAUUAUGUTT ACAUAAUUUAGCAACACUCTT 13414.1
S553 AUUAUGUUUGGAUGCCGGCTT GCCGGCAUCCAAACAUAAUTT 13459.4
S554 UUAUGUUUGGAUGCCGGCATT UGCCGGCAUCCAAACAUAATT 13459.4
S555 UUAUGUGAAGUCACCCAAATT UUUGGGUGACUUCACAUAATT 13429.2
S556 GUCACCCAAAUUUUCUAAATT UUUAGAAAAUUUGGGUGACTT 13414.1
S557 AUUGUUCACAAUCGCUAUGTT CAUAGCGAUUGUGAACAAUTT 13429.2
S558 UUGUUCACAAUCGCUAUGUTT ACAUAGCGAUUGUGAACAATT 13429.2
S559 UCGCUAUGUGGCUAUUGUUTT AACAAUAGCCACAUAGCGATT 13444.3
S560 GUAUUUGCUUAGGUUCUCUTT AGAGAACCUAAGCAAAUACTT 13429.2
S561 UCUGUGUAACUGCUGCUUUTT AAAGCAGCAGUUACACAGATT 13444.3
S562 CUGCUGCUUUUGGUGUACUTT AGUACACCAAAAGCAGCAGTT 13459.4
S563 UUUUGGUGCUCCUUCUUAUTT AUAAGAAGGAGCACCAAAATT 13429.2
S564 UGGCGUUAGAGAAUUGUAUTT AUACAAUUCUCUAACGCCATT 13429.2
S565 UUCGUCUAACGUUACUACUTT AGUAGUAACGUUAGACGAATT 13429.2
S566 CGUUACUACUAUGGAUUUCTT GAAAUCCAUAGUAGUAACGTT 13429.2
S567 GGUUCUUUUCCUUGCAGCATT UGCUGCAAGGAAAAGAACCTT 13459.4
S568 GUGGAUUAGACUCCCUUGATT UCAAGGGAGUCUAAUCCACTT 13459.4
S569 ACCAUUCAGGUGACGAUUUTT AAAUCGUCACCUGAAUGGUTT 13444.3
S570 CCAUUCAGGUGACGAUUUCTT GAAAUCGUCACCUGAAUGGTT 13459.4
S571 GCUAGACUUGACAAUUUUATT UAAAAUUGUCAAGUCUAGCTT 13414.1
S572 UUUUAGGUCUGGCCGCUGATT UCAGCGGCCAGACCUAAAATT 13474.5
S573 UGCAGGUGUUCUUUGGCUATT UAGCCAAAGAACACCUGCATT 13459.4
S574 UUCUUGGCUCAUGUGGUUUTT AAACCACAUGAGCCAAGAATT 13444.3
S575 AUGGCACCCGUUUCUGCAATT UUGCAGAAACGGGUGCCAUTT 13474.5
S576 UGGCACCCGUUUCUGCAAUTT AUUGCAGAAACGGGUGCCATT 13474.5
S577 UGGUUAGGAUGUACAUCUUTT AAGAUGUACAUCCUAACCATT 13429.2
S578 GAGCUAUGUUCAUAUCAUGTT CAUGAUAUGAACAUAGCUCTT 13429.2
S579 GCGCAAUCGUGCCACACGCTT GCGUGUGGCACGAUUGCGCTT 13519.8
S580 UCGUGCCACACGCGUUGAGTT CUCAACGCGUGUGGCACGATT 13504.7
S581 CUAUUGUUAAUGGCAUGAATT UUCAUGCCAUUAACAAUAGTT 13414.1
S582 UGGCAUGAAGAGAUCUUUCTT GAAAGAUCUCUUCAUGCCATT 13444.3
S583 GAGAUCUUUCUAUGUCUAUTT AUAGACAUAGAAAGAUCUCTT 13414.1
S584 AUGGAGGCCGUGGCUUCUGTT CAGAAGCCACGGCCUCCAUTT 13504.7
S585 UGGAGGCCGUGGCUUCUGCTT GCAGAAGCCACGGCCUCCATT 13519.8
S586 GACUCACAAUUGGAAUUGUTT ACAAUUCCAAUUGUGAGUCTT 13429.2
S587 UUGGAAUUGUCUCAAUUGUTT ACAAUUGAGACAAUUCCAATT 13414.1
S588 UUGUCUCAAUUGUGACACATT UGUGUCACAAUUGAGACAATT 13429.2
S589 UUGUGACACAUUUUGCACUTT AGUGCAAAAUGUGUCACAATT 13429.2
S590 GUUGCUCGUGAUUUGUCACTT GUGACAAAUCACGAGCAACTT 13459.4
S591 AAGACCAAUCAACCCUACUTT AGUAGGGUUGAUUGGUCUUTT 13444.3
S592 AGACCAAUCAACCCUACUGTT CAGUAGGGUUGAUUGGUCUTT 13459.4
S593 GACCAAUCAACCCUACUGATT UCAGUAGGGUUGAUUGGUCTT 13459.4
S594 UCAACCCUACUGACCAGUCTT GACUGGUCAGUAGGGUUGATT 13474.5
S595 CCCUACUGACCAGUCAUCGTT CGAUGACUGGUCAGUAGGGTT 13489.6
S596 AAAUGGCGCGCUUCACCUCTT GAGGUGAAGCGCGCCAUUUTT 13489.6
S597 AAUGGCGCGCUUCACCUCUTT AGAGGUGAAGCGCGCCAUUTT 13489.6
S598 AUGGCGCGCUUCACCUCUATT UAGAGGUGAAGCGCGCCAUTT 13489.6
S599 UGGCGCGCUUCACCUCUACTT GUAGAGGUGAAGCGCGCCATT 13504.7
S600 GGCUGGUCAAAAGACCUAUTT AUAGGUCUUUUGACCAGCCTT 13459.4
S601 AAGACCUAUGAGAGACAUCTT GAUGUCUCUCAUAGGUCUUTT 13444.3
S602 AGACCUAUGAGAGACAUCCTT GGAUGUCUCUCAUAGGUCUTT 13459.4
S603 GACCUAUGAGAGACAUCCGTT CGGAUGUCUCUCAUAGGUCTT 13474.5
S604 UUUAGACAAUUUGAGAGCUTT AGCUCUCAAAUUGUCUAAATT 13414.1
S605 UUUGAGAGCUAACAACACUTT AGUGUUGUUAGCUCUCAAATT 13429.2
S606 CAACACUAAAGGUUCACUGTT CAGUGAACCUUUAGUGUUGTT 13444.3
S607 CACUAAAGGUUCACUGCCUTT AGGCAGUGAACCUUUAGUGTT 13459.4
S608 AGGUUCACUGCCUAUUAAUTT AUUAAUAGGCAGUGAACCUTT 13429.2
S609 GGUUCACUGCCUAUUAAUGTT CAUUAAUAGGCAGUGAACCTT 13444.3
S610 UGUCAUAGUUUUUGAUGGCTT GCCAUCAAAAACUAUGACATT 13429.2
S611 GUCCAAAUGCGACGAGUCUTT AGACUCGUCGCAUUUGGACTT 13474.5
S612 AUGCGACGAGUCUGCUUCUTT AGAAGCAGACUCGUCGCAUTT 13474.5
S613 UGCGACGAGUCUGCUUCUATT UAGAAGCAGACUCGUCGCATT 13474.5
S614 GUCUGCUUCUGUGUACUACTT GUAGUACACAGAAGCAGACTT 13459.4
S615 CCUAUUCUGUUGCUUGACCTT GGUCAAGCAACAGAAUAGGTT 13459.4
S616 GCUCUUGUAUCAGACGUUGTT CAACGUCUGAUACAAGAGCTT 13459.4
S617 GUUUCCGUUAAGAUGUUUGTT CAAACAUCUUAACGGAAACTT 13429.2
S618 GAUGUUUGAUGCUUAUGUCTT GACAUAAGCAUCAAACAUCTT 13429.2
S619 CUUUUAGUGUUCCUAUGGATT UCCAUAGGAACACUAAAAGTT 13429.2
S620 AAACUUAAGGCACUUGUUGTT CAACAAGUGCCUUAAGUUUTT 13429.2
S621 AACUUAAGGCACUUGUUGCTT GCAACAAGUGCCUUAAGUUTT 13444.3
S622 ACUUAAGGCACUUGUUGCUTT AGCAACAAGUGCCUUAAGUTT 13444.3
S623 CUUAAGGCACUUGUUGCUATT UAGCAACAAGUGCCUUAAGTT 13444.3
S624 GGCACUUGUUGCUACAGCUTT AGCUGUAGCAACAAGUGCCTT 13474.5
S625 AGGGUGUAGCUUUAGAUGGTT CCAUCUAAAGCUACACCCUTT 13459.4
S626 GGGUGUAGCUUUAGAUGGUTT ACCAUCUAAAGCUACACCCTT 13459.4
S627 GGUGUUGUUGAUACCGAUGTT CAUCGGUAUCAACAACACCTT 13459.4
S628 AGGAUGUUAUUGAAUGUCUTT AGACAUUCAAUAACAUCCUTT 13414.1
S629 GGAUGUUAUUGAAUGUCUCTT GAGACAUUCAAUAACAUCCTT 13429.2
S630 UGUCUCAAACUUUCACAUCTT GAUGUGAAAGUUUGAGACATT 13429.2
S631 ACUUUCACAUCACUCUGACTT GUCAGAGUGAUGUGAAAGUTT 13444.3
S632 CUUUCACAUCACUCUGACUTT AGUCAGAGUGAUGUGAAAGTT 13444.3
S633 GUGACAGGUGACAGUUGUATT UACAACUGUCACCUGUCACTT 13459.4
S634 CAAUUUCAUGCUCACCUAUTT AUAGGUGAGCAUGAAAUUGTT 13429.2
S635 UUUCAUGCUCACCUAUAAUTT AUUAUAGGUGAGCAUGAAATT 13414.1
S636 UAAGGUUGAAAACAUGACGTT CGUCAUGUUUUCAACCUUATT 13429.2
S637 GGUUGAAAACAUGACGCCCTT GGGCGUCAUGUUUUCAACCTT 13474.5
S638 AACAUGACGCCCAGAGAUCTT GAUCUCUGGGCGUCAUGUUTT 13474.5
S639 ACAUGACGCCCAGAGAUCUTT AGAUCUCUGGGCGUCAUGUTT 13474.5
S640 CAUGACGCCCAGAGAUCUUTT AAGAUCUCUGGGCGUCAUGTT 13474.5
S641 UGCAAGGCAUAUCAAUGCCTT GGCAUUGAUAUGCCUUGCATT 13459.4
S642 GGCAUAUCAAUGCCCAAGUTT ACUUGGGCAUUGAUAUGCCTT 13459.4
S643 UGCCCAAGUAGCAAAAAGUTT ACUUUUUGCUACUUGGGCATT 13444.3
S644 GUAGCAAAAAGUCACAAUGTT CAUUGUGACUUUUUGCUACTT 13429.2
S645 AAAGUCACAAUGUUUCACUTT AGUGAAACAUUGUGACUUUTT 13414.1
S646 AAGUCACAAUGUUUCACUCTT GAGUGAAACAUUGUGACUUTT 13429.2
S647 AGUCACAAUGUUUCACUCATT UGAGUGAAACAUUGUGACUTT 13429.2
S648 GUCACAAUGUUUCACUCAUTT AUGAGUGAAACAUUGUGACTT 13429.2
S649 UGUUUCACUCAUCUGGAAUTT AUUCCAGAUGAGUGAAACATT 13429.2
S650 UGUAAAAGACUACAUGUCUTT AGACAUGUAGUCUUUUACATT 13414.1
S651 AAGACUACAUGUCUUUAUCTT GAUAAAGACAUGUAGUCUUTT 13414.1
S652 AGACUACAUGUCUUUAUCUTT AGAUAAAGACAUGUAGUCUTT 13414.1
S653 GACUACAUGUCUUUAUCUGTT CAGAUAAAGACAUGUAGUCTT 13429.2
S654 CAGCUGCGUAAACAAAUUCTT GAAUUUGUUUACGCAGCUGTT 13444.3
S655 ACAAAUUCGUAGUGCUGCCTT GGCAGCACUACGAAUUUGUTT 13459.4
S656 CAAAUUCGUAGUGCUGCCATT UGGCAGCACUACGAAUUUGTT 13459.4
S657 AUUCGUAGUGCUGCCAAGATT UCUUGGCAGCACUACGAAUTT 13459.4
S658 UUCGUAGUGCUGCCAAGAATT UUCUUGGCAGCACUACGAATT 13459.4
S659 GAAGAACAACAUACCUUUUTT AAAAGGUAUGUUGUUCUUCTT 13414.1
S660 GAACAACAUACCUUUUAGATT UCUAAAAGGUAUGUUGUUCTT 13414.1
S661 CAACAUACCUUUUAGACUATT UAGUCUAAAAGGUAUGUUGTT 13414.1
S662 CAUACCUUUUAGACUAACUTT AGUUAGUCUAAAAGGUAUGTT 13414.1
S663 CUUGUGCUACAACUAGACATT UGUCUAGUUGUAGCACAAGTT 13444.3
S664 CUAGACAGGUUGUCAAUGUTT ACAUUGACAACCUGUCUAGTT 13444.3
S665 CUACUAAAAUCUCACUCAATT UUGAGUGAGAUUUUAGUAGTT 13414.1
S666 AAUCUCACUCAAGGGUGGUTT ACCACCCUUGAGUGAGAUUTT 13459.4
S667 AUCUCACUCAAGGGUGGUATT UACCACCCUUGAGUGAGAUTT 13459.4
S668 UCUCACUCAAGGGUGGUAATT UUACCACCCUUGAGUGAGATT 13459.4
S669 GGGUGGUAAGAUUGUUAGUTT ACUAACAAUCUUACCACCCTT 13444.3
S670 ACUUAUGCUUAAGGCCACATT UGUGGCCUUAAGCAUAAGUTT 13444.3
S671 CUUAUGCUUAAGGCCACAUTT AUGUGGCCUUAAGCAUAAGTT 13444.3
S672 GGCCACAUUAUUGUGCGUUTT AACGCACAAUAAUGUGGCCTT 13459.4
S673 UCCAUGAUGGUUACACAAATT UUUGUGUAACCAUCAUGGATT 13429.2
S674 AUCAUUGGUUACAAAGCCATT UGGCUUUGUAACCAAUGAUTT 13429.2
S675 UCAUUGGUUACAAAGCCAUTT AUGGCUUUGUAACCAAUGATT 13429.2
S676 AGCCAUUCAGGAUGGUGUCTT GACACCAUCCUGAAUGGCUTT 13474.5
S677 GCCAUUCAGGAUGGUGUCATT UGACACCAUCCUGAAUGGCTT 13474.5
S678 AUAAACAUGCUGGUUUUGATT UCAAAACCAGCAUGUUUAUTT 13414.1
S679 UAAACAUGCUGGUUUUGACTT GUCAAAACCAGCAUGUUUATT 13429.2
S680 ACAUGCUGGUUUUGACGCATT UGCGUCAAAACCAGCAUGUTT 13459.4
S681 CAUGCUGGUUUUGACGCAUTT AUGCGUCAAAACCAGCAUGTT 13459.4
S682 AAAUGACAAAAGCUGCCCUTT AGGGCAGCUUUUGUCAUUUTT 13444.3
S683 AAUGACAAAAGCUGCCCUGTT CAGGGCAGCUUUUGUCAUUTT 13459.4
S684 AUGACAAAAGCUGCCCUGUTT ACAGGGCAGCUUUUGUCAUTT 13459.4
S685 UGACAAAAGCUGCCCUGUATT UACAGGGCAGCUUUUGUCATT 13459.4
S686 AAGCUGCCCUGUAGUAGCUTT AGCUACUACAGGGCAGCUUTT 13474.5
S687 AGCUGCCCUGUAGUAGCUGTT CAGCUACUACAGGGCAGCUTT 13489.6
S688 GCUGCCCUGUAGUAGCUGCTT GCAGCUACUACAGGGCAGCTT 13504.7
S689 GAGAGAUUGGUUUCAUAGUTT ACUAUGAAACCAAUCUCUCTT 13429.2
S690 UCAAUGGUGACUUCUUGCATT UGCAAGAAGUCACCAUUGATT 13444.3
S691 UGGUGACUUCUUGCAUUUUTT AAAAUGCAAGAAGUCACCATT 13429.2
S692 CAUUUGCUACACACCUUCCTT GGAAGGUGUGUAGCAAAUGTT 13459.4
S693 ACUCAUUGAGUAUAGUGAUTT AUCACUAUACUCAAUGAGUTT 13414.1
S694 CUCAUUGAGUAUAGUGAUUTT AAUCACUAUACUCAAUGAGTT 13414.1
S695 UUUUUAAGGAUGCUAUGGGTT CCCAUAGCAUCCUUAAAAATT 13429.2
S696 GGAUGCUAUGGGCAAACCUTT AGGUUUGCCCAUAGCAUCCTT 13474.5
S697 ACCUGUGCCAUAUUGUUAUTT AUAACAAUAUGGCACAGGUTT 13429.2
S698 CCUGUGCCAUAUUGUUAUGTT CAUAACAAUAUGGCACAGGTT 13444.3
S699 UUUGCUAGAGGGUUCUAUUTT AAUAGAACCCUCUAGCAAATT 13429.2
S700 CACUUACCUGGAGGGUUCUTT AGAACCCUCCAGGUAAGUGTT 13474.5
S701 CAACUUUUGAUGCUGAGUATT UACUCAGCAUCAAAAGUUGTT 13429.2
S702 CUUUUGAUGCUGAGUACUGTT CAGUACUCAGCAUCAAAAGTT 13444.3
S703 AGGUCAGAAGUAGGUAUUUTT AAAUACCUACUUCUGACCUTT 13429.2
S704 GGUCAGAAGUAGGUAUUUGTT CAAAUACCUACUUCUGACCTT 13444.3
S705 GUAGGUAUUUGCCUAUCUATT UAGAUAGGCAAAUACCUACTT 13429.2
S706 UAAUGAGCAUUACAGAGCUTT AGCUCUGUAAUGCUCAUUATT 13429.2
S707 UGAGCAUUACAGAGCUCUATT UAGAGCUCUGUAAUGCUCATT 13444.3
S708 UCUCAUAGCUAACAUCUUUTT AAAGAUGUUAGCUAUGAGATT 13414.1
S709 CAUCUUUACUCCUCUUGUGTT CACAAGAGGAGUAAAGAUGTT 13444.3
S710 CCUGUGGGUGCUUUAGAUGTT CAUCUAAAGCACCCACAGGTT 13474.5
S711 AUUCAGACGUGUUUUUGGUTT ACCAAAAACACGUCUGAAUTT 13429.2
S712 UUCAGACGUGUUUUUGGUGTT CACCAAAAACACGUCUGAATT 13444.3
S713 CCAUGUUGUUGCUGCUAAUTT AUUAGCAGCAACAACAUGGTT 13444.3
S714 UGCACUUUUGUUUUUGAUGTT CAUCAAAAACAAAAGUGCATT 13414.1
S715 UGAUGUUUCAUUCUUGGCUTT AGCCAAGAAUGAAACAUCATT 13429.2
S716 UGGUUUGCCAUGUUUUCUCTT GAGAAAACAUGGCAAACCATT 13444.3
S717 CAGCAAUCUAUGUAUUCUGTT CAGAAUACAUAGAUUGCUGTT 13429.2
S718 GCACUGCCAUUGGUUCUUUTT AAAGAACCAAUGGCAGUGCTT 13459.4
S719 CAACUAUCUUAGGAAAAGATT UCUUUUCCUAAGAUAGUUGTT 13414.1
S720 CUAUCUUAGGAAAAGAGUCTT GACUCUUUUCCUAAGAUAGTT 13429.2
S721 AAGAGUCAUGUUUAAUGGATT UCCAUUAAACAUGACUCUUTT 13414.1
S722 AGAGUCAUGUUUAAUGGAGTT CUCCAUUAAACAUGACUCUTT 13429.2
S723 GAGUCAUGUUUAAUGGAGUTT ACUCCAUUAAACAUGACUCTT 13429.2
S724 CAAGGAAAUGUACCUAAAATT UUUUAGGUACAUUUCCUUGTT 13414.1
S725 GGAAAUGUACCUAAAAUUGTT CAAUUUUAGGUACAUUUCCTT 13414.1
S726 AUGUACCUAAAAUUGCGUATT UACGCAAUUUUAGGUACAUTT 13414.1
S727 UGUACCUAAAAUUGCGUAGTT CUACGCAAUUUUAGGUACATT 13429.2
S728 AAUUGCGUAGCGAGACACUTT AGUGUCUCGCUACGCAAUUTT 13459.4
S729 AUUGCGUAGCGAGACACUGTT CAGUGUCUCGCUACGCAAUTT 13474.5
S730 UUGCGUAGCGAGACACUGUTT ACAGUGUCUCGCUACGCAATT 13474.5
S731 CAGGUAUCUUGCUCUAUAUTT AUAUAGAGCAAGAUACCUGTT 13429.2
S732 CAAGUACAAGUAUUUCAGUTT ACUGAAAUACUUGUACUUGTT 13414.1
S733 GUACAAGUAUUUCAGUGGATT UCCACUGAAAUACUUGUACTT 13429.2
S734 GUAUUUCAGUGGAGCCUUATT UAAGGCUCCACUGAAAUACTT 13444.3
S735 GCAGCUUGCUGCCACUUAGTT CUAAGUGGCAGCAAGCUGCTT 13489.6
S736 AGGCUCUAAAUGACUUUAGTT CUAAAGUCAUUUAGAGCCUTT 13429.2
S737 GGCUCUAAAUGACUUUAGCTT GCUAAAGUCAUUUAGAGCCTT 13444.3
S738 AUGACUUUAGCAACUCAGGTT CCUGAGUUGCUAAAGUCAUTT 13444.3
S739 UGACUUUAGCAACUCAGGUTT ACCUGAGUUGCUAAAGUCATT 13444.3
S740 CUCAGGUGCUGAUGUUCUCTT GAGAACAUCAGCACCUGAGTT 13474.5
S741 CCACCACAGACAUCAAUCATT UGAUUGAUGUCUGUGGUGGTT 13459.4
S742 UCACUUCUGCUGUUCUGCATT UGCAGAACAGCAGAAGUGATT 13459.4
S743 AAUGGCAUUCCCGUCAGGCTT GCCUGACGGGAAUGCCAUUTT 13489.6
S744 AUGGCAUUCCCGUCAGGCATT UGCCUGACGGGAAUGCCAUTT 13489.6
S745 UGGCAUUCCCGUCAGGCAATT UUGCCUGACGGGAAUGCCATT 13489.6
S746 AGUUGAAGGGUGCAUGGUATT UACCAUGCACCCUUCAACUTT 13459.4
S747 GUUGAAGGGUGCAUGGUACTT GUACCAUGCACCCUUCAACTT 13474.5
S745 GGGUGCAUGGUACAAGUAATT UUACUUGUACCAUGCACCCTT 13459.4
S749 GUAACCUGUGGAACUACAATT UUGUAGUUCCACAGGUUACTT 13444.3
S750 CCUGUGGAACUACAACUCUTT AGAGUUGUAGUUCCACAGGTT 13459.4
S751 CUACAACUCUUAAUGGAUUTT AAUCCAUUAAGAGUUGUAGTT 13414.1
S752 UGGAUUGUGGUUGGAUGACTT GUCAUCCAACCACAAUCCATT 13459.4
S753 GACAUGUCAUUUGCACAGCTT GCUGUGCAAAUGACAUGUCTT 13459.4
S754 GACAUGCUUAAUCCUAACUTT AGUUAGGAUUAAGCAUGUCTT 13429.2
S755 UCCUAACUAUGAAGAUCUGTT CAGAUCUUCAUAGUUAGGATT 13429.2
S756 CUAUGAAGAUCUGCUCAUUTT AAUGAGCAGAUCUUCAUAGTT 13429.2
S757 GAUCUGCUCAUUCGCAAAUTT AUUUGCGAAUGAGCAGAUCTT 13444.3
S758 AUCCAACCAUAGCUUUCUUTT AAGAAAGCUAUGGUUGGAUTT 13429.2
S759 UCCAACCAUAGCUUUCUUGTT CAAGAAAGCUAUGGUUGGATT 13444.3
S760 CCAUAGCUUUCUUGUUCAGTT CUGAACAAGAAAGCUAUGGTT 13444.3
S761 UGUUCAACUUCGUGUUAUUTT AAUAACACGAAGUUGAACATT 13414.1
S762 CUUCGUGUUAUUGGCCAUUTT AAUGGCCAAUAACACGAAGTT 13444.3
S763 AAUUGUCUGCUUAGGCUUATT UAAGCCUAAGCAGACAAUUTT 13429.2
S764 AUUGUCUGCUUAGGCUUAATT UUAAGCCUAAGCAGACAAUTT 13429.2
S765 UUGUCUGCUUAGGCUUAAATT UUUAAGCCUAAGCAGACAATT 13429.2
S766 AGUUGAUACUUCUAACCCUTT AGGGUUAGAAGUAUCAACUTT 13429.2
S767 GUUGAUACUUCUAACCCUATT UAGGGUUAGAAGUAUCAACTT 13429.2
S768 CCCUAAGACACCCAAGUAUTT AUACUUGGGUGUCUUAGGGTT 13459.4
S769 GACACCCAAGUAUAAAUUUTT AAAUUUAUACUUGGGUGUCTT 13414.1
S770 GUAUAAAUUUGUCCGUAUCTT GAUACGGACAAAUUUAUACTT 13414.1
S771 AUUUGUCCGUAUCCAACCUTT AGGUUGGAUACGGACAAAUTT 13444.3
S772 UUUGUCCGUAUCCAACCUGTT CAGGUUGGAUACGGACAAATT 13459.4
S773 CCUGGUCAAACAUUUUCAGTT CUGAAAAUGUUUGACCAGGTT 13444.3
S774 ACAUUUUCAGUUCUAGCAUTT AUGCUAGAACUGAAAAUGUTT 13414.1
S775 CAUUUUCAGUUCUAGCAUGTT CAUGCUAGAACUGAAAAUGTT 13429.2
S776 UGGUUCACCAUCUGGUGUUTT AACACCAGAUGGUGAACCATT 13459.4
S777 UCAUACCAUUAAAGGUUCUTT AGAACCUUUAAUGGUAUGATT 13414.1
S778 AGGUUCUUUCCUUAAUGGATT UCCAUUAAGGAAAGAACCUTT 13429.2
S779 GGUUCUUUCCUUAAUGGAUTT AUCCAUUAAGGAAAGAACCTT 13429.2
S780 UGGAUCAUGUGGUAGUGUUTT AACACUACCACAUGAUCCATT 13444.3
S781 CAUUGAUUAUGAUUGCGUGTT CACGCAAUCAUAAUCAAUGTT 13429.2
S782 CAGGAGUACACGCUGGUACTT GUACCAGCGUGUACUCCUGTT 13489.6
S783 GGUAAAUUCUAUGGUCCAUTT AUGGACCAUAGAAUUUACCTT 13429.2
S784 AUUCUAUGGUCCAUUUGUUTT AACAAAUGGACCAUAGAAUTT 13414.1
S785 UUCUAUGGUCCAUUUGUUGTT CAACAAAUGGACCAUAGAATT 13429.2
S786 ACUGCACAGGCUGCAGGUATT UACCUGCAGCCUGUGCAGUTT 13489.6
S787 CUGCACAGGCUGCAGGUACTT GUACCUGCAGCCUGUGCAGTT 13504.7
S788 CAUUAAAUGUUUUGGCAUGTT CAUGCCAAAACAUUUAAUGTT 13414.1
S789 AUGUUUUGGCAUGGCUGUATT UACAGCCAUGCCAAAACAUTT 13444.3
S790 UGUUUUGGCAUGGCUGUAUTT AUACAGCCAUGCCAAAACATT 13444.3
S791 UGGUGAUAGGUGGUUUCUUTT AAGAAACCACCUAUCACCATT 13444.3
S792 UAGAUUCACCACUACUUUGTT CAAAGUAGUGGUGAAUCUATT 13429.2
S793 UGACUUUAACCUUGUGGCATT UGCCACAAGGUUAAAGUCATT 13444.3
S794 CCUUGUGGCAAUGAAGUACTT GUACUUCAUUGCCACAAGGTT 13459.4
S795 UGAAGUACAACUAUGAACCTT GGUUCAUAGUUGUACUUCATT 13429.2
S796 GUACAACUAUGAACCUUUGTT CAAAGGUUCAUAGUUGUACTT 13429.2
S797 CUAUGAACCUUUGACACAATT UUGUGUCAAAGGUUCAUAGTT 13429.2
S798 CCUUUGACACAAGAUCAUGTT CAUGAUCUUGUGUCAAAGGTT 13444.3
S799 GAUCAUGUUGACAUAUUGGTT CCAAUAUGUCAACAUGAUCTT 13429.2
S800 ACAGGAAUUGCCGUCUUAGTT CUAAGACGGCAAUUCCUGUTT 13459.4
S801 CAGGAAUUGCCGUCUUAGATT UCUAAGACGGCAAUUCCUGTT 13459.4
S802 UUGCCGUCUUAGAUAUGUGTT CACAUAUCUAAGACGGCAATT 13444.3
S803 AGAGCUGCUGCAGAAUGGUTT ACCAUUCUGCAGCAGCUCUTT 13474.5
S804 GAGCUGCUGCAGAAUGGUATT UACCAUUCUGCAGCAGCUCTT 13474.5
S805 UGGUAUGAAUGGUCGUACUTT AGUACGACCAUUCAUACCATT 13444.3
S806 UGGUCGUACUAUCCUUGGUTT ACCAAGGAUAGUACGACCATT 13459.4
S807 GAUGAGUUUACACCAUUUGTT CAAAUGGUGUAAACUCAUCTT 13429.2
S808 UGCUCUGGUGUUACCUUCCTT GGAAGGUAACACCAGAGCATT 13474.5
S809 GGUAAGUUCAAGAAAAUUGTT CAAUUUUCUUGAACUUACCTT 13414.1
S810 GAAAAUUGUUAAGGGCACUTT AGUGCCCUUAACAAUUUUCTT 13429.2
S811 AAUUGUUAAGGGCACUCAUTT AUGAGUGCCCUUAACAAUUTT 13429.2
S812 AUUGUUAAGGGCACUCAUCTT GAUGAGUGCCCUUAACAAUTT 13444.3
S813 UUGUUAAGGGCACUCAUCATT UGAUGAGUGCCCUUAACAATT 13444.3
S814 GGGCACUCAUCAUUGGAUGTT CAUCCAAUGAUGAGUGCCCTT 13474.5
S815 CUUUCUUGACAUCACUAUUTT AAUAGUGAUGUCAAGAAAGTT 13414.1
S816 AGUACACAGUGGUCACUGUTT ACAGUGACCACUGUGUACUTT 13459.4
S817 GUACACAGUGGUCACUGUUTT AACAGUGACCACUGUGUACTT 13459.4
S818 UGCUUUCUUGCCAUUUACUTT AGUAAAUGGCAAGAAAGCATT 13429.2
S819 UUGCUGCAUGUGCUAUGCUTT AGCAUAGCACAUGCAGCAATT 13459.4
S820 GCAUAAGCACGCAUUCUUGTT CAAGAAUGCGUGCUUAUGCTT 13459.4
S821 GCACGCAUUCUUGUGCUUGTT CAAGCACAAGAAUGCGUGCTT 13474.5
S822 UAUGGUCUACAUGCCUGCUTT AGCAGGCAUGUAGACCAUATT 13459.4
S823 UUGGCUGACACUAGCUUGUTT ACAAGCUAGUGUCAGCCAATT 13459.4
S824 GGAUUGUGUUAUGUAUGCUTT AGCAUACAUAACACAAUCCTT 13429.2
S825 UGUCAUUACACUUGUUUACTT GUAAACAAGUGUAAUGACATT 13414.1
S826 AGUCUACUAUGGUAAUGCUTT AGCAUUACCAUAGUAGACUTT 13429.2
S827 GUCUACUAUGGUAAUGCUUTT AAGCAUUACCAUAGUAGACTT 13429.2
S828 UGCUUUAGAUCAAGCUAUUTT AAUAGCUUGAUCUAAAGCATT 13414.1
S829 GCUAUUUCCAUGUGGGCCUTT AGGCCCACAUGGAAAUAGCTT 13474.5
S830 CCUCUAACUAUUCUGGUGUTT ACACCAGAAUAGUUAGAGGTT 13444.3
S831 CUAUUCUGGUGUCGUUACGTT CGUAACGACACCAGAAUAGTT 13459.4
S832 CACCUUACAGUGUAUCAUGTT CAUGAUACACUGUAAGGUGTT 13444.3
S833 CCGUUACUUCAGGCUUACUTT AGUAAGCCUGAAGUAACGGTT 13459.4
S834 UUUAGGUAUAUGAACUCCCTT GGGAGUUCAUAUACCUAAATT 13429.2
S835 CUCCCAGGGGCUUUUGCCUTT AGGCAAAAGCCCCUGGGAGTT 13504.7
S836 GAGUAGUAUUGAUGCUUUCTT GAAAGCAUCAAUACUACUCTT 13429.2
S837 CAUUAAGUUGUUGGGUAUUTT AAUACCCAACAACUUAAUGTT 13414.1
S838 GUUGUUGGGUAUUGGAGGUTT ACCUCCAAUACCCAACAACTT 13459.4
S839 ACCAUGUAUCAAGGUUGCUTT AGCAACCUUGAUACAUGGUTT 13444.3
S840 CCAUGUAUCAAGGUUGCUATT UAGCAACCUUGAUACAUGGTT 13444.3
S841 GGUUGCUACUGUACAGUCUTT AGACUGUACAGUAGCAACCTT 13459.4
S842 AAUGUCUGACGUAAAGUGCTT GCACUUUACGUCAGACAUUTT 13444.3
S843 AUGUCUGACGUAAAGUGCATT UGCACUUUACGUCAGACAUTT 13444.3
S844 UGUCUGACGUAAAGUGCACTT GUGCACUUUACGUCAGACATT 13459.4
S845 AGUGCACAUCUGUGGUACUTT AGUACCACAGAUGUGCACUTT 13459.4
S846 GUGCACAUCUGUGGUACUGTT CAGUACCACAGAUGUGCACTT 13474.5
S847 CAACUUAGAGUAGAGUCAUTT AUGACUCUACUCUAAGUUGTT 13429.2
S848 CUUAGAGUAGAGUCAUCUUTT AAGAUGACUCUACUCUAAGTT 13429.2
S849 AUUGUGGGCACAAUGUGUATT UACACAUUGUGCCCACAAUTT 13444.3
S850 UUGUGGGCACAAUGUGUACTT GUACACAUUGUGCCCACAATT 13459.4
S851 UGUGUACAACUCCACAAUGTT CAUUGUGGAGUUGUACACATT 13444.3
S852 CUCCACAAUGAUAUUCUUCTT GAAGAAUAUCAUUGUGGAGTT 13429.2
S853 AAGACACAACUGAAGCUUUTT AAAGCUUCAGUUGUGUCUUTT 13429.2
S854 AGACACAACUGAAGCUUUCTT GAAAGCUUCAGUUGUGUCUTT 13444.3
S855 GACACAACUGAAGCUUUCGTT CGAAAGCUUCAGUUGUGUCTT 13459.4
S856 CUGAAGCUUUCGAGAAGAUTT AUCUUCUCGAAAGCUUCAGTT 13444.3
S857 GCUUUCGAGAAGAUGGUUUTT AAACCAUCUUCUCGAAAGCTT 13444.3
S858 GAUGGUUUCUCUUUUGUCUTT AGACAAAAGAGAAACCAUCTT 13429.2
S859 UAGGUUGUGCGAGGAAAUGTT CAUUUCCUCGCACAACCUATT 13459.4
S860 AUGCUCGAUAACCGUGCUATT UAGCACGGUUAUCGAGCAUTT 13459.4
S861 UGCUCGAUAACCGUGCUACTT GUAGCACGGUUAUCGAGCATT 13474.5
S862 CCGUGCUACUCUUCAGGCUTT AGCCUGAAGAGUAGCACGGTT 13489.6
S863 UGGUGAUUCUGAAGUCGUUTT AACGACUUCAGAAUCACCATT 13444.3
S864 GUCGUUCUCAAAAAGUUAATT UUAACUUUUUGAGAACGACTT 13414.1
S865 AGAAAUCUUUGAAUGUGGCTT GCCACAUUCAAAGAUUUCUTT 13429.2
S866 GAAAUCUUUGAAUGUGGCUTT AGCCACAUUCAAAGAUUUCTT 13429.2
S867 AUCUUUGAAUGUGGCUAAATT UUUAGCCACAUUCAAAGAUTT 13414.1
S868 UCUUUGAAUGUGGCUAAAUTT AUUUAGCCACAUUCAAAGATT 13414.1
S869 AUCUGAGUUUGACCGUGAUTT AUCACGGUCAAACUCAGAUTT 13444.3
S870 UCUGAGUUUGACCGUGAUGTT CAUCACGGUCAAACUCAGATT 13459.4
S871 CGCAAGUUGGAAAAGAUGGTT CCAUCUUUUCCAACUUGCGTT 13459.4
S872 GUUGGAAAAGAUGGCAGAUTT AUCUGCCAUCUUUUCCAACTT 13444.3
S873 AAGAUGGCAGAUCAGGCUATT UAGCCUGAUCUGCCAUCUUTT 13459.4
S874 AGAUGGCAGAUCAGGCUAUTT AUAGCCUGAUCUGCCAUCUTT 13459.4
S875 GAUGGCAGAUCAGGCUAUGTT CAUAGCCUGAUCUGCCAUCTT 13474.5
S876 AUGUACAAACAGGCAAGAUTT AUCUUGCCUGUUUGUACAUTT 13429.2
S877 UGUACAAACAGGCAAGAUCTT GAUCUUGCCUGUUUGUACATT 13444.3
S878 ACAGGCAAGAUCUGAGGACTT GUCCUCAGAUCUUGCCUGUTT 13474.5
S879 CAGGCAAGAUCUGAGGACATT UGUCCUCAGAUCUUGCCUGTT 13474.5
S880 GAUCUGAGGACAAGAGGGCTT GCCCUCUUGUCCUCAGAUCTT 13489.6
S881 GAGGGCAAAAGUAACUAGUTT ACUAGUUACUUUUGCCCUCTT 13444.3
S882 AAGUAACUAGUGCUAUGCATT UGCAUAGCACUAGUUACUUTT 13429.2
S883 AGUAACUAGUGCUAUGCAATT UUGCAUAGCACUAGUUACUTT 13429.2
S884 GUAACUAGUGCUAUGCAAATT UUUGCAUAGCACUAGUUACTT 13429.2
S885 CUAGUGCUAUGCAAACAAUTT AUUGUUUGCAUAGCACUAGTT 13429.2
S886 ACAAUGCUCUUCACUAUGCTT GCAUAGUGAAGAGCAUUGUTT 13444.3
S887 UGCUCUUCACUAUGCUUAGTT CUAAGCAUAGUGAAGAGCATT 13444.3
S888 GCUUGAUAAUGAUGCACUUTT AAGUGCAUCAUUAUCAAGCTT 13429.2
S889 UGAUGCACUUAACAACAUUTT AAUGUUGUUAAGUGCAUCATT 13414.1
S890 CAACAUUAUCAACAAUGCGTT CGCAUUGUUGAUAAUGUUGTT 13429.2
S891 CAUUAUCAACAAUGCGCGUTT ACGCGCAUUGUUGAUAAUGTT 13444.3
S892 CAAUGCGCGUGAUGGUUGUTT ACAACCAUCACGCGCAUUGTT 13474.5
S893 UGCGCGUGAUGGUUGUGUUTT AACACAACCAUCACGCGCATT 13474.5
S894 CAUCAUACCAUUGACUACATT UGUAGUCAAUGGUAUGAUGTT 13429.2
S895 ACUCAUGGUUGUUGUCCCUTT AGGGACAACAACCAUGAGUTT 13459.4
S896 CUCAUGGUUGUUGUCCCUGTT CAGGGACAACAACCAUGAGTT 13474.5
S897 GAACACUUGUGAUGGUAACTT GUUACCAUCACAAGUGUUCTT 13444.3
S898 CACUUGUGAUGGUAACACCTT GGUGUUACCAUCACAAGUGTT 13459.4
S899 CACCUUUACAUAUGCAUCUTT AGAUGCAUAUGUAAAGGUGTT 13429.2
S900 AUCCAGCAAGUUGUUGAUGTT CAUCAACAACUUGCUGGAUTT 13444.3
S901 UCCAGCAAGUUGUUGAUGCTT GCAUCAACAACUUGCUGGATT 13459.4
S902 GUUGUUGAUGCGGAUAGCATT UGCUAUCCGCAUCAACAACTT 13459.4
S903 GAUUGUUCAACUUAGUGAATT UUCACUAAGUUGAACAAUCTT 13414.1
S904 CUUAGUGAAAUUAACAUGGTT CCAUGUUAAUUUCACUAAGTT 13414.1
S905 AUUAACAUGGACAAUUCACTT GUGAAUUGUCCAUGUUAAUTT 13414.1
S906 UUAACAUGGACAAUUCACCTT GGUGAAUUGUCCAUGUUAATT 13429.2
S907 CAUGGACAAUUCACCAAAUTT AUUUGGUGAAUUGUCCAUGTT 13429.2
S908 UUCACCAAAUUUGGCUUGGTT CCAAGCCAAAUUUGGUGAATT 13444.3
S909 AUUUGGCUUGGCCUCUUAUTT AUAAGAGGCCAAGCCAAAUTT 13444.3
S910 UUUGGCUUGGCCUCUUAUUTT AAUAAGAGGCCAAGCCAAATT 13444.3
S911 GAGCCAACUCAGCUGUUAATT UUAACAGCUGAGUUGGCUCTT 13459.4
S912 CUCAGCUGUUAAACUACAGTT CUGUAGUUUAACAGCUGAGTT 13444.3
S913 ACUACAGAAUAAUGAACUGTT CAGUUCAUUAUUCUGUAGUTT 13414.1
S914 CUACAGAAUAAUGAACUGATT UCAGUUCAUUAUUCUGUAGTT 13414.1
S915 UAAUGAACUGAGUCCAGUATT UACUGGACUCAGUUCAUUATT 13429.2
S916 UGAACUGAGUCCAGUAGCATT UGCUACUGGACUCAGUUCATT 13459.4
S917 CUGAGUCCAGUAGCACUACTT GUAGUGCUACUGGACUCAGTT 13474.5
S918 ACAGCUUGUACUGAUGACATT UGUCAUCAGUACAAGCUGUTT 13444.3
S919 CAGCUUGUACUGAUGACAATT UUGUCAUCAGUACAAGCUGTT 13444.3
S920 UGCACUUGCCUACUAUAACTT GUUAUAGUAGGCAAGUGCATT 13444.3
S921 CAAUUCGAAGGGAGGUAGGTT CCUACCUCCCUUCGAAUUGTT 13474.5
S922 UUCGAAGGGAGGUAGGUUUTT AAACCUACCUCCCUUCGAATT 13459.4
S923 GGGAGGUAGGUUUGUGCUGTT CAGCACAAACCUACCUCCCTT 13489.6
S924 GAUCUCAAAUGGGCUAGAUTT AUCUAGCCCAUUUGAGAUCTT 13444.3
S925 AUGGGCUAGAUUCCCUAAGTT CUUAGGGAAUCUAGCCCAUTT 13459.4
S926 UGGGCUAGAUUCCCUAAGATT UCUUAGGGAAUCUAGCCCATT 13459.4
S927 GAGUGAUGGUACAGGUACATT UGUACCUGUACCAUCACUCTT 13459.4
S928 UUUACACAGAACUGGAACCTT GGUUCCAGUUCUGUGUAAATT 13444.3
S929 CUGGAACCACCUUGUAGGUTT ACCUACAAGGUGGUUCCAGTT 13474.5
S930 CCACCUUGUAGGUUUGUUATT UAACAAACCUACAAGGUGGTT 13444.3
S931 AAGGGCCUAAAGUGAAAUATT UAUUUCACUUUAGGCCCUUTT 13429.2
S932 AGGGCCUAAAGUGAAAUACTT GUAUUUCACUUUAGGCCCUTT 13444.3
S933 GGGCCUAAAGUGAAAUACUTT AGUAUUUCACUUUAGGCCCTT 13444.3
S934 AGUGAAAUACUUGUACUUCTT GAAGUACAAGUAUUUCACUTT 13414.1
S935 GUGAAAUACUUGUACUUCATT UGAAGUACAAGUAUUUCACTT 13414.1
S936 UACUUGUACUUCAUCAAAGTT CUUUGAUGAAGUACAAGUATT 13414.1
S937 AGGCUUAAACAACCUAAAUTT AUUUAGGUUGUUUAAGCCUTT 13414.1
S938 GGCUUAAACAACCUAAAUATT UAUUUAGGUUGUUUAAGCCTT 13414.1
S939 ACAACCUAAAUAGAGGUAUTT AUACCUCUAUUUAGGUUGUTT 13414.1
S940 CAACCUAAAUAGAGGUAUGTT CAUACCUCUAUUUAGGUUGTT 13429.2
S941 CCUAAAUAGAGGUAUGGUGTT CACCAUACCUCUAUUUAGGTT 13444.3
S942 AUAGAGGUAUGGUGCUGGGTT CCCAGCACCAUACCUCUAUTT 13474.5
S943 UAGAGGUAUGGUGCUGGGCTT GCCCAGCACCAUACCUCUATT 13489.6
S944 AUGCUACAGAAGUACCUGCTT GCAGGUACUUCUGUAGCAUTT 13459.4
S945 UGCUACAGAAGUACCUGCCTT GGCAGGUACUUCUGUAGCATT 13474.5
S946 GUACCUGCCAAUUCAACUGTT CAGUUGAAUUGGCAGGUACTT 13459.4
S947 UUCAACUGUGCUUUCCUUCTT GAAGGAAAGCACAGUUGAATT 13444.3
S948 CUGUGCUUUCCUUCUGUGCTT GCACAGAAGGAAAGCACAGTT 13474.5
S949 AGCAUAUAAGGAUUACCUATT UAGGUAAUCCUUAUAUGCUTT 13414.1
S950 GCAUAUAAGGAUUACCUAGTT CUAGGUAAUCCUUAUAUGCTT 13429.2
S951 GGAUUACCUAGCAAGUGGATT UCCACUUGCUAGGUAAUCCTT 13459.4
S952 GUGGAGGACAACCAAUCACTT GUGAUUGGUUGUCCUCCACTT 13474.5
S953 CCAAUCACCAACUGUGUGATT UCACACAGUUGGUGAUUGGTT 13459.4
S954 UCACCAACUGUGUGAAGAUTT AUCUUCACACAGUUGGUGATT 13444.3
S955 CUGUGUGAAGAUGUUGUGUTT ACACAACAUCUUCACACAGTT 13444.3
S956 GAUGUUGUGUACACACACUTT AGUGUGUGUACACAACAUCTT 13444.3
S957 UUACUGUAACACCAGAAGCTT GCUUCUGGUGUUACAGUAATT 13444.3
S958 CACCAGAAGCUAACAUGGATT UCCAUGUUAGCUUCUGGUGTT 13459.4
S959 GCUAACAUGGACCAAGAGUTT ACUCUUGGUCCAUGUUAGCTT 13459.4
S960 CAUGGACCAAGAGUCCUUUTT AAAGGACUCUUGGUCCAUGTT 13459.4
S961 GAGUCCUUUGGUGGUGCUUTT AAGCACCACCAAAGGACUCTT 13474.5
S962 AUCCUAAAGGAUUCUGUGATT UCACAGAAUCCUUUAGGAUTT 13429.2
S963 UCCUAAAGGAUUCUGUGACTT GUCACAGAAUCCUUUAGGATT 13444.3
S964 AGGAUUCUGUGACUUGAAATT UUUCAAGUCACAGAAUCCUTT 13429.2
S965 GGAUUCUGUGACUUGAAAGTT CUUUCAAGUCACAGAAUCCTT 13444.3
S966 AGGUAAGUACGUCCAAAUATT UAUUUGGACGUACUUACCUTT 13429.2
S967 GGUAAGUACGUCCAAAUACTT GUAUUUGGACGUACUUACCTT 13444.3
S968 GUACGUCCAAAUACCUACCTT GGUAGGUAUUUGGACGUACTT 13459.4
S969 AUACCUACCACUUGUGCUATT UAGCACAAGUGGUAGGUAUTT 13444.3
S970 UACCUACCACUUGUGCUAATT UUAGCACAAGUGGUAGGUATT 13444.3
S971 UGACCCAGUGGGUUUUACATT UGUAAAACCCACUGGGUCATT 13459.4
S972 ACACAGUCUGUACCGUCUGTT CAGACGGUACAGACUGUGUTT 13474.5
S973 CACAGUCUGUACCGUCUGCTT GCAGACGGUACAGACUGUGTT 13489.6
S974 UGUGGAAAGGUUAUGGCUGTT CAGCCAUAACCUUUCCACATT 13459.4
S975 AGGUUAUGGCUGUAGUUGUTT ACAACUACAGCCAUAACCUTT 13444.3
S976 GGUUAUGGCUGUAGUUGUGTT CACAACUACAGCCAUAACCTT 13459.4
S977 CUCCGCGAACCCUUGAUGCTT GCAUCAAGGGUUCGCGGAGTT 13504.7
S978 CCCUUGAUGCAGUCUGCGGTT CCGCAGACUGCAUCAAGGGTT 13504.7
S979 CGUUUUUAAACGGGUUUGCTT GCAAACCCGUUUAAAAACGTT 13444.3
S980 ACGGGUUUGCGGUGUAAGUTT ACUUACACCGCAAACCCGUTT 13474.5
S981 CGGGUUUGCGGUGUAAGUGTT CACUUACACCGCAAACCCGTT 13489.6
S982 GUGCAGCCCGUCUUACACCTT GGUGUAAGACGGGCUGCACTT 13504.7
S983 CGAAAAAGUUGCUGGUUUUTT AAAACCAGCAACUUUUUCGTT 13429.2
S984 AAAGUUGCUGGUUUUGCAATT UUGCAAAACCAGCAACUUUTT 13429.2
S985 AAGUUGCUGGUUUUGCAAATT UUUGCAAAACCAGCAACUUTT 13429.2
S986 AGUUGCUGGUUUUGCAAAGTT CUUUGCAAAACCAGCAACUTT 13444.3
S987 GUUGCUGGUUUUGCAAAGUTT ACUUUGCAAAACCAGCAACTT 13444.3
S988 GUUCCUAAAAACUAAUUGCTT GCAAUUAGUUUUUAGGAACTT 13414.1
S989 AAACUAAUUGCUGUCGCUUTT AAGCGACAGCAAUUAGUUUTT 13429.2
S990 AACUAAUUGCUGUCGCUUCTT GAAGCGACAGCAAUUAGUUTT 13444.3
S991 ACUAAUUGCUGUCGCUUCCTT GGAAGCGACAGCAAUUAGUTT 13459.4
S992 GGCAAUUUAUUAGACUCUUTT AAGAGUCUAAUAAAUUGCCTT 13414.1
S993 GAGACUAUUUAUAACUUGGTT CCAAGUUAUAAAUAGUCUCTT 13414.1
S994 CUUGGUUAAAGAUUGUCCATT UGGACAAUCUUUAACCAAGTT 13429.2
S995 AGAUUGUCCAGCGGUUGCUTT AGCAACCGCUGGACAAUCUTT 13474.5
S996 CUAAAUACACAAUGGCUGATT UCAGCCAUUGUGUAUUUAGTT 13429.2
S997 AUACACAAUGGCUGAUUUATT UAAAUCAGCCAUUGUGUAUTT 13414.1
S998 UACACAAUGGCUGAUUUAGTT CUAAAUCAGCCAUUGUGUATT 13429.2
S999 AAGAAAUACUCGUCACAUATT UAUGUGACGAGUAUUUCUUTT 13414.1
S1000 AGAAAUACUCGUCACAUACTT GUAUGUGACGAGUAUUUCUTT 13429.2
S1001 GAAAUACUCGUCACAUACATT UGUAUGUGACGAGUAUUUCTT 13429.2
S1002 AUACUCGUCACAUACAAUUTT AAUUGUAUGUGACGAGUAUTT 13414.1
S1003 UACUCGUCACAUACAAUUGTT CAAUUGUAUGUGACGAGUATT 13429.2
S1004 UUGCUGUGAUGAUGAUUAUTT AUAAUCAUCAUCACAGCAATT 13414.1
S1005 UAAGAAGGAUUGGUAUGACTT GUCAUACCAAUCCUUCUUATT 13429.2
S1006 AGACUGUACAAUUCUGCGATT UCGCAGAAUUGUACAGUCUTT 13444.3
S1007 UCAGGAUCUUAAUGGGAACTT GUUCCCAUUAAGAUCCUGATT 13444.3
S1008 UGGGAACUGGUACGAUUUCTT GAAAUCGUACCAGUUCCCATT 13459.4
S1009 GUAGCACCAGGCUGCGGAGTT CUCCGCAGCCUGGUGCUACTT 13519.8
S1010 AACCACUUAUUAAGUGGGATT UCCCACUUAAUAAGUGGUUTT 13429.2
S1011 ACCACUUAUUAAGUGGGAUTT AUCCCACUUAAUAAGUGGUTT 13429.2
S1012 CCACUUAUUAAGUGGGAUUTT AAUCCCACUUAAUAAGUGGTT 13429.2
S1013 GUGGGAUUUGCUGAAAUAUTT AUAUUUCAGCAAAUCCCACTT 13429.2
S1014 AUAUGAUUUUACGGAAGAGTT CUCUUCCGUAAAAUCAUAUTT 13414.1
S1015 UAUGAUUUUACGGAAGAGATT UCUCUUCCGUAAAAUCAUATT 13414.1
S1016 AUAUUGGGACCAGACAUACTT GUAUGUCUGGUCCCAAUAUTT 13444.3
S1017 UAUUGGGACCAGACAUACCTT GGUAUGUCUGGUCCCAAUATT 13459.4
S1018 UGUGUUAUUUUCUACUGUGTT CACAGUAGAAAAUAACACATT 13414.1
S1019 GUUUUGGACCACUAGUAAGTT CUUACUAGUGGUCCAAAACTT 13444.3
S1020 AUAUUUGUAGAUGGUGUUCTT GAACACCAUCUACAAAUAUTT 13414.1
S1021 UAUUUGUAGAUGGUGUUCCTT GGAACACCAUCUACAAAUATT 13429.2
S1022 CUGGAUACCAUUUUCGUGATT UCACGAAAAUGGUAUCCAGTT 13444.3
S1023 UCAGGAUGUAAACUUACAUTT AUGUAAGUUUACAUCCUGATT 13414.1
S1024 ACUUACAUAGCUCGCGUCUTT AGACGCGAGCUAUGUAAGUTT 13459.4
S1025 GGAACUUUUAGUGUAUGCUTT AGCAUACACUAAAAGUUCCTT 13429.2
S1026 CUUUUAGUGUAUGCUGCUGTT CAGCAGCAUACACUAAAAGTT 13444.3
S1027 UUUAUUGCUAGAUAAACGCTT GCGUUUAUCUAGCAAUAAATT 13414.1
S1028 ACGCACUACAUGCUUUUCATT UGAAAAGCAUGUAGUGCGUTT 13444.3
S1029 CGCACUACAUGCUUUUCAGTT CUGAAAAGCAUGUAGUGCGTT 13459.4
S1030 CAAACAAUGUUGCUUUUCATT UGAAAAGCAACAUUGUUUGTT 13414.1
S1031 ACAAUGUUGCUUUUCAAACTT GUUUGAAAAGCAACAUUGUTT 13414.1
S1032 CAAUGUUGCUUUUCAAACUTT AGUUUGAAAAGCAACAUUGTT 13414.1
S1033 UGUUGCUUUUCAAACUGUCTT GACAGUUUGAAAAGCAACATT 13429.2
S1034 ACUGUCAAACCCGGUAAUUTT AAUUACCGGGUUUGACAGUTT 13444.3
S1035 CUGUCAAACCCGGUAAUUUTT AAAUUACCGGGUUUGACAGTT 13444.3
S1036 CCCGGUAAUUUUAAUAAAGTT CUUUAUUAAAAUUACCGGGTT 13414.1
S1037 AGACUUUUAUGACUUUGCUTT AGCAAAGUCAUAAAAGUCUTT 13414.1
S1038 GACUUUUAUGACUUUGCUGTT CAGCAAAGUCAUAAAAGUCTT 13429.2
S1039 AGGUUUCUUUAAGGAAGGATT UCCUUCCUUAAAGAAACCUTT 13429.2
S1040 GGUUUCUUUAAGGAAGGAATT UUCCUUCCUUAAAGAAACCTT 13429.2
S1041 GGAAGUUCUGUUGAACUAATT UUAGUUCAACAGAACUUCCTT 13429.2
S1042 GUUCUGUUGAACUAAAACATT UGUUUUAGUUCAACAGAACTT 13414.1
S1043 CUAAAACACUUCUUCUUUGTT CAAAGAAGAAGUGUUUUAGTT 13414.1
S1044 AACACUUCUUCUUUGCUCATT UGAGCAAAGAAGAAGUGUUTT 13429.2
S1045 ACACUUCUUCUUUGCUCAGTT CUGAGCAAAGAAGAAGUGUTT 13444.3
S1046 CAAUGUGUGAUAUCAGACATT UGUCUGAUAUCACACAUUGTT 13429.2
S1047 UGUGUGAUAUCAGACAACUTT AGUUGUCUGAUAUCACACATT 13429.2
S1048 UACUUUGAUUGUUACGAUGTT CAUCGUAACAAUCAAAGUATT 13414.1
S1049 CCAAGUAAUCGUUAACAAUTT AUUGUUAACGAUUACUUGGTT 13414.1
S1050 GUAAUCGUUAACAAUCUGGTT CCAGAUUGUUAACGAUUACTT 13429.2
S1051 UCGUUAACAAUCUGGAUAATT UUAUCCAGAUUGUUAACGATT 13414.1
S1052 CAAUCUGGAUAAAUCAGCUTT AGCUGAUUUAUCCAGAUUGTT 13429.2
S1053 AUCAGCUGGUUUCCCAUUUTT AAAUGGGAAACCAGCUGAUTT 13444.3
S1054 UCAGCUGGUUUCCCAUUUATT UAAAUGGGAAACCAGCUGATT 13444.3
S1055 UAAAUGGGGUAAGGCUAGATT UCUAGCCUUACCCCAUUUATT 13444.3
S1056 AUGGGGUAAGGCUAGACUUTT AAGUCUAGCCUUACCCCAUTT 13459.4
S1057 UGGGGUAAGGCUAGACUUUTT AAAGUCUAGCCUUACCCCATT 13459.4
S1058 GGCUAGACUUUAUUAUGACTT GUCAUAAUAAAGUCUAGCCTT 13429.2
S1059 UGAGUUAUGAGGAUCAAGATT UCUUGAUCCUCAUAACUCATT 13429.2
S1060 GAUGCACUUUUCGCGUAUATT UAUACGCGAAAAGUGCAUCTT 13444.3
S1061 GCGUAAUGUCAUCCCUACUTT AGUAGGGAUGACAUUACGCTT 13459.4
S1062 UGUCAUCCCUACUAUAACUTT AGUUAUAGUAGGGAUGACATT 13429.2
S1063 AUGAAUCUUAAGUAUGCCATT UGGCAUACUUAAGAUUCAUTT 13414.1
S1064 UGAAUCUUAAGUAUGCCAUTT AUGGCAUACUUAAGAUUCATT 13414.1
S1065 UCUUAAGUAUGCCAUUAGUTT ACUAAUGGCAUACUUAAGATT 13414.1
S1066 AGAAUAGAGCUCGCACCGUTT ACGGUGCGAGCUCUAUUCUTT 13474.5
S1067 AUAGACAGUUUCAUCAGAATT UUCUGAUGAAACUGUCUAUTT 13414.1
S1068 UAGACAGUUUCAUCAGAAATT UUUCUGAUGAAACUGUCUATT 13414.1
S1069 AUUAUUGAAGUCAAUAGCCTT GGCUAUUGACUUCAAUAAUTT 13414.1
S1070 UUAUUGAAGUCAAUAGCCGTT CGGCUAUUGACUUCAAUAATT 13429.2
S1071 UAGCCGCCACUAGAGGAGCTT GCUCCUCUAGUGGCGGCUATT 13504.7
S1072 UUGGAACAAGCAAGUUUUATT UAAAACUUGCUUGUUCCAATT 13414.1
S1073 CAAGCAAGUUUUACGGUGGTT CCACCGUAAAACUUGCUUGTT 13459.4
S1074 GCAAGUUUUACGGUGGCUGTT CAGCCACCGUAAAACUUGCTT 13474.5
S1075 GUUUUACGGUGGCUGGCAUTT AUGCCAGCCACCGUAAAACTT 13474.5
S1076 AAACUGUUUACAGUGAUGUTT ACAUCACUGUAAACAGUUUTT 13414.1
S1077 AACUGUUUACAGUGAUGUATT UACAUCACUGUAAACAGUUTT 13414.1
S1078 ACUGUUUACAGUGAUGUAGTT CUACAUCACUGUAAACAGUTT 13429.2
S1079 CUGUUUACAGUGAUGUAGATT UCUACAUCACUGUAAACAGTT 13429.2
S1080 CUCCACACCUUAUGGGUUGTT CAACCCAUAAGGUGUGGAGTT 13474.5
S1081 AAUGUGACAGAGCCAUGCCTT GGCAUGGCUCUGUCACAUUTT 13474.5
S1082 AUGUGACAGAGCCAUGCCUTT AGGCAUGGCUCUGUCACAUTT 13474.5
S1083 ACAUAACACUUGCUGUAACTT GUUACAGCAAGUGUUAUGUTT 13429.2
S1084 CAUAACACUUGCUGUAACUTT AGUUACAGCAAGUGUUAUGTT 13429.2
S1085 CACUUGCUGUAACUUAUCATT UGAUAAGUUACAGCAAGUGTT 13429.2
S1086 GUAUUAAGUGAGAUGGUCATT UGACCAUCUCACUUAAUACTT 13429.2
S1087 ACCAGGUGGAACAUCAUCCTT GGAUGAUGUUCCACCUGGUTT 13474.5
S1088 CUGCUUAUGCUAAUAGUGUTT ACACUAUUAGCAUAAGCAGTT 13429.2
S1089 CAUUUGUCAAGCUGUUACATT UGUAACAGCUUGACAAAUGTT 13429.2
S1090 UGUAAAUGCACUUCUUUCATT UGAAAGAAGUGCAUUUACATT 13414.1
S1091 AUGCACUUCUUUCAACUGATT UCAGUUGAAAGAAGUGCAUTT 13429.2
S1092 UGCACUUCUUUCAACUGAUTT AUCAGUUGAAAGAAGUGCATT 13429.2
S1093 CUGAUGGUAAUAAGAUAGCTT GCUAUCUUAUUACCAUCAGTT 13429.2
S1094 AUAGGGAUGUUGAUCAUGATT UCAUGAUCAACAUCCCUAUTT 13429.2
S1095 UAGGGAUGUUGAUCAUGAATT UUCAUGAUCAACAUCCCUATT 13429.2
S1096 UUCGUGGAUGAGUUUUACGTT CGUAAAACUCAUCCACGAATT 13444.3
S1097 ACAUUUCUCCAUGAUGAUUTT AAUCAUCAUGGAGAAAUGUTT 13414.1
S1098 CAUUUCUCCAUGAUGAUUCTT GAAUCAUCAUGGAGAAAUGTT 13429.2
S1099 GGUUUAGUAGCUAGCAUUATT UAAUGCUAGCUACUAAACCTT 13429.2
S1100 GAACUUUAAGGCAGUUCUUTT AAGAACUGCCUUAAAGUUCTT 13429.2
S1101 CUUUAAGGCAGUUCUUUAUTT AUAAAGAACUGCCUUAAAGTT 13414.1
S1102 GGCAGUUCUUUAUUAUCAATT UUGAUAAUAAAGAACUGCCTT 13414.1
S1103 AAUAAUGUGUUCAUGUCUGTT CAGACAUGAACACAUUAUUTT 13414.1
S1104 AUAAUGUGUUCAUGUCUGATT UCAGACAUGAACACAUUAUTT 13414.1
S1105 UAAUGUGUUCAUGUCUGAGTT CUCAGACAUGAACACAUUATT 13429.2
S1106 AAUGUUGGACUGAGACUGATT UCAGUCUCAGUCCAACAUUTT 13444.3
S1107 AUGUUGGACUGAGACUGACTT GUCAGUCUCAGUCCAACAUTT 13459.4
S1108 AGGACCUCACGAAUUUUGCTT GCAAAAUUCGUGAGGUCCUTT 13459.4
S1109 GGACCUCACGAAUUUUGCUTT AGCAAAAUUCGUGAGGUCCTT 13459.4
S1110 UUUUGCUCACAGCAUACAATT UUGUAUGCUGUGAGCAAAATT 13429.2
S1111 UGCUAGUUAAACAAGGAGATT UCUCCUUGUUUAACUAGCATT 13429.2
S1112 ACAAGGAGAUGAUUACGUGTT CACGUAAUCAUCUCCUUGUTT 13444.3
S1113 AACAGAUGGUACACUUAUGTT CAUAAGUGUACCAUCUGUUTT 13429.2
S1114 ACAGAUGGUACACUUAUGATT UCAUAAGUGUACCAUCUGUTT 13429.2
S1115 CAGAUGGUACACUUAUGAUTT AUCAUAAGUGUACCAUCUGTT 13429.2
S1116 AGGUUCGUGUCACUGGCUATT UAGCCAGUGACACGAACCUTT 13474.5
S1117 AACAUCCUAAUCAGGAGUATT UACUCCUGAUUAGGAUGUUTT 13429.2
S1118 ACAUCCUAAUCAGGAGUAUTT AUACUCCUGAUUAGGAUGUTT 13429.2
S1119 UCAGGAGUAUGCUGAUGUCTT GACAUCAGCAUACUCCUGATT 13459.4
S1120 AGUUACAUGAUGAGCUUACTT GUAAGCUCAUCAUGUAACUTT 13429.2
S1121 GUUACAUGAUGAGCUUACUTT AGUAAGCUCAUCAUGUAACTT 13429.2
S1122 UGCUAACUAAUGAUAACACTT GUGUUAUCAUUAGUUAGCATT 13414.1
S1123 CACCUCACGGUACUGGGAATT UUCCCAGUACCGUGAGGUGTT 13489.6
S1124 CCUGAGUUUUAUGAGGCUATT UAGCCUCAUAAAACUCAGGTT 13444.3
S1125 CAUCACACAAAUUAGUGUUTT AACACUAAUUUGUGUGAUGTT 13414.1
S1126 UUAGUGUUGUCUGUUAAUCTT GAUUAACAGACAACACUAATT 13414.1
S1127 UCCCUAUGUUUGCAAUGCCTT GGCAUUGCAAACAUAGGGATT 13459.4
S1128 UGCCCCAGGUUGUGAUGUCTT GACAUCACAACCUGGGGCATT 13489.6
S1129 GUCACAUAAGCCUCCCAUUTT AAUGGGAGGCUUAUGUGACTT 13459.4
S1130 GCCUCCCAUUAGUUUUCCATT UGGAAAACUAAUGGGAGGCTT 13459.4
S1131 UGGUCAGGUUUUUGGUUUATT UAAACCAAAAACCUGACCATT 13429.2
S1132 AAACACAUGUGUAGGCAGUTT ACUGCCUACACAUGUGUUUTT 13444.3
S1133 AACACAUGUGUAGGCAGUGTT CACUGCCUACACAUGUGUUTT 13459.4
S1134 ACACAUGUGUAGGCAGUGATT UCACUGCCUACACAUGUGUTT 13459.4
S1135 CACAUGUGUAGGCAGUGACTT GUCACUGCCUACACAUGUGTT 13474.5
S1136 UGUCACUGACUUCAAUGCGTT CGCAUUGAAGUCAGUGACATT 13459.4
S1137 UGCGAUAGCAACAUGUGAUTT AUCACAUGUUGCUAUCGCATT 13444.3
S1138 CAUGUGAUUGGACUAAUGCTT GCAUUAGUCCAAUCACAUGTT 13444.3
S1139 UGCUGGCGAUUACAUACUUTT AAGUAUGUAAUCGCCAGCATT 13444.3
S1140 CACUUGUACUGAGAGACUCTT GAGUCUCUCAGUACAAGUGTT 13459.4
S1141 GCUUUUCGCAGCAGAAACGTT CGUUUCUGCUGCGAAAAGCTT 13474.5
S1142 ACGCUCAAAGCCACUGAGGTT CCUCAGUGGCUUUGAGCGUTT 13489.6
S1143 CGCUCAAAGCCACUGAGGATT UCCUCAGUGGCUUUGAGCGTT 13489.6
S1144 AGCCACUGAGGAAACAUUUTT AAAUGUUUCCUCAGUGGCUTT 13444.3
S1145 GCCACUGAGGAAACAUUUATT UAAAUGUUUCCUCAGUGGCTT 13444.3
S1146 ACAUUUAAGCUGUCAUAUGTT CAUAUGACAGCUUAAAUGUTT 13414.1
S1147 CAUUUAAGCUGUCAUAUGGTT CCAUAUGACAGCUUAAAUGTT 13429.2
S1148 GCUGUCAUAUGGUAUUGCCTT GGCAAUACCAUAUGACAGCTT 13459.4
S1149 GUACUCUCUGACAGAGAAUTT AUUCUCUGUCAGAGAGUACTT 13444.3
S1150 UUGCAUCUUUCAUGGGAGGTT CCUCCCAUGAAAGAUGCAATT 13459.4
S1151 AACCUAGACCACCAUUGAATT UUCAAUGGUGGUCUAGGUUTT 13444.3
S1152 ACCUAGACCACCAUUGAACTT GUUCAAUGGUGGUCUAGGUTT 13459.4
S1153 CCUAGACCACCAUUGAACATT UGUUCAAUGGUGGUCUAGGTT 13459.4
S1154 CAGAAACUAUGUCUUUACUTT AGUAAAGACAUAGUUUCUGTT 13414.1
S1155 ACUAUGUCUUUACUGGUUATT UAACCAGUAAAGACAUAGUTT 13414.1
S1156 CUAUGUCUUUACUGGUUACTT GUAACCAGUAAAGACAUAGTT 13429.2
S1157 AUAGUAAAGUACAGAUUGGTT CCAAUCUGUACUUUACUAUTT 13414.1
S1158 UAGUAAAGUACAGAUUGGATT UCCAAUCUGUACUUUACUATT 13414.1
S1159 AGUACAGAUUGGAGAGUACTT GUACUCUCCAAUCUGUACUTT 13444.3
S1160 GUACAGAUUGGAGAGUACATT UGUACUCUCCAAUCUGUACTT 13444.3
S1161 AAAGGUGACUAUGGUGAUGTT CAUCACCAUAGUCACCUUUTT 13444.3
S1162 AAGGUGACUAUGGUGAUGCTT GCAUCACCAUAGUCACCUUTT 13459.4
S1163 AGGUGACUAUGGUGAUGCUTT AGCAUCACCAUAGUCACCUTT 13459.4
S1164 GGUGACUAUGGUGAUGCUGTT CAGCAUCACCAUAGUCACCTT 13474.5
S1165 GUUGAAUGUUGGUGAUUACTT GUAAUCACCAACAUUCAACTT 13429.2
S1166 UGUUGGUGAUUACUUUGUGTT CACAAAGUAAUCACCAACATT 13429.2
S1167 UGCCACUUAGUGCACCUACTT GUAGGUGCACUAAGUGGCATT 13474.5
S1168 GAGCACUAUGUGAGAAUUATT UAAUUCUCACAUAGUGCUCTT 13429.2
S1169 UUACUGGCUUGUACCCAACTT GUUGGGUACAAGCCAGUAATT 13459.4
S1170 CACUCAACAUCUCAGAUGATT UCAUCUGAGAUGUUGAGUGTT 13444.3
S1171 CAUCUCAGAUGAGUUUUCUTT AGAAAACUCAUCUGAGAUGTT 13429.2
S1172 AUUAUCAAAAGGUCGGCAUTT AUGCCGACCUUUUGAUAAUTT 13429.2
S1173 UUAUCAAAAGGUCGGCAUGTT CAUGCCGACCUUUUGAUAATT 13444.3
S1174 AAGGUCGGCAUGCAAAAGUTT ACUUUUGCAUGCCGACCUUTT 13459.4
S1175 AGGUCGGCAUGCAAAAGUATT UACUUUUGCAUGCCGACCUTT 13459.4
S1176 GGUCGGCAUGCAAAAGUACTT GUACUUUUGCAUGCCGACCTT 13474.5
S1177 AAGUACUCUACACUCCAAGTT CUUGGAGUGUAGAGUACUUTT 13444.3
S1178 AGUACUCUACACUCCAAGGTT CCUUGGAGUGUAGAGUACUTT 13459.4
S1179 GUACUCUACACUCCAAGGATT UCCUUGGAGUGUAGAGUACTT 13459.4
S1180 GGACCACCUGGUACUGGUATT UACCAGUACCAGGUGGUCCTT 13489.6
S1181 GAGUCAUUUUGCCAUCGGATT UCCGAUGGCAAAAUGACUCTT 13459.4
S1182 AGGCAUUAAAAUAUUUGCCTT GGCAAAUAUUUUAAUGCCUTT 13414.1
S1183 GGCAUUAAAAUAUUUGCCCTT GGGCAAAUAUUUUAAUGCCTT 13429.2
S1184 AUGUAGUAGAAUCAUACCUTT AGGUAUGAUUCUACUACAUTT 13414.1
S1185 UGUAGUAGAAUCAUACCUGTT CAGGUAUGAUUCUACUACATT 13429.2
S1186 UCAUACCUGCGCGUGCGCGTT CGCGCACGCGCAGGUAUGATT 13519.8
S1187 UUCAAAGUGAAUUCAACACTT GUGUUGAAUUCACUUUGAATT 13414.1
S1188 AGUGAAUUCAACACUAGAATT UUCUAGUGUUGAAUUCACUTT 13414.1
S1189 GUGAAUUCAACACUAGAACTT GUUCUAGUGUUGAAUUCACTT 13429.2
S1190 UUCAACACUAGAACAGUAUTT AUACUGUUCUAGUGUUGAATT 13414.1
S1191 CACUAGAACAGUAUGUUUUTT AAAACAUACUGUUCUAGUGTT 13414.1
S1192 CAGUAUGUUUUCUGCACUGTT CAGUGCAGAAAACAUACUGTT 13444.3
S1193 AUGCAUUGCCAGAAACAACTT GUUGUUUCUGGCAAUGCAUTT 13444.3
S1194 UGCAUUGCCAGAAACAACUTT AGUUGUUUCUGGCAAUGCATT 13444.3
S1195 ACAACUGCUGACAUUGUAGTT CUACAAUGUCAGCAGUUGUTT 13444.3
S1196 CAACUGCUGACAUUGUAGUTT ACUACAAUGUCAGCAGUUGTT 13444.3
S1197 CUGCUGACAUUGUAGUCUUTT AAGACUACAAUGUCAGCAGTT 13444.3
S1198 AUCUCUAUGGCUACUAAUUTT AAUUAGUAGCCAUAGAGAUTT 13414.1
S1199 UCUCUAUGGCUACUAAUUATT UAAUUAGUAGCCAUAGAGATT 13414.1
S1200 UUAUGACUUGAGUGUUGUCTT GACAACACUCAAGUCAUAATT 13429.2
S1201 UGCUAGACUUCGUGCAAAATT UUUUGCACGAAGUCUAGCATT 13444.3
S1202 AACACUACGUCUAUAUUGGTT CCAAUAUAGACGUAGUGUUTT 13429.2
S1203 ACACUACGUCUAUAUUGGCTT GCCAAUAUAGACGUAGUGUTT 13444.3
S1204 CACUACGUCUAUAUUGGCGTT CGCCAAUAUAGACGUAGUGTT 13459.4
S1205 UUACCAGCCCCCCGCACAUTT AUGUGCGGGGGGCUGGUAATT 13504.7
S1206 AGGCACACUAGAACCAGAATT UUCUGGUUCUAGUGUGCCUTT 13459.4
S1207 GGCACACUAGAACCAGAAUTT AUUCUGGUUCUAGUGUGCCTT 13459.4
S1208 UUCAGUGUGCAGACUUAUGTT CAUAAGUCUGCACACUGAATT 13444.3
S1209 AACAAUAGGUCCAGACAUGTT CAUGUCUGGACCUAUUGUUTT 13444.3
S1210 ACAAUAGGUCCAGACAUGUTT ACAUGUCUGGACCUAUUGUTT 13444.3
S1211 CAAUAGGUCCAGACAUGUUTT AACAUGUCUGGACCUAUUGTT 13444.3
S1212 UAGGUCCAGACAUGUUCCUTT AGGAACAUGUCUGGACCUATT 13459.4
S1213 CUUGUCGCCGUUGUCCUGCTT GCAGGACAACGGCGACAAGTT 13504.7
S1214 AUUGUUGACACUGUGAGUGTT CACUCACAGUGUCAACAAUTT 13444.3
S1215 UUGUUGACACUGUGAGUGCTT GCACUCACAGUGUCAACAATT 13459.4
S1216 UAAGCUAAAAGCACACAAGTT CUUGUGUGCUUUUAGCUUATT 13429.2
S1217 GCUAAAAGCACACAAGGAUTT AUCCUUGUGUGCUUUUAGCTT 13444.3
S1218 AAGCACACAAGGAUAAGUCTT GACUUAUCCUUGUGUGCUUTT 13444.3
S1219 AGCACACAAGGAUAAGUCATT UGACUUAUCCUUGUGUGCUTT 13444.3
S1220 GCACACAAGGAUAAGUCAGTT CUGACUUAUCCUUGUGUGCTT 13459.4
S1221 GGAUAAGUCAGCUCAAUGCTT GCAUUGAGCUGACUUAUCCTT 13459.4
S1222 GUCAGCUCAAUGCUUCAAATT UUUGAAGCAUUGAGCUGACTT 13444.3
S1223 UGCUUCAAAAUGUUCUACATT UGUAGAACAUUUUGAAGCATT 13414.1
S1224 AAUGUUCUACAAAGGUGUUTT AACACCUUUGUAGAACAUUTT 13414.1
S1225 AUGUUCUACAAAGGUGUUATT UAACACCUUUGUAGAACAUTT 13414.1
S1226 UGUUCUACAAAGGUGUUAUTT AUAACACCUUUGUAGAACATT 13414.1
S1227 AGGUGUUAUUACACAUGAUTT AUCAUGUGUAAUAACACCUTT 13414.1
S1228 GGUGUUAUUACACAUGAUGTT CAUCAUGUGUAAUAACACCTT 13429.2
S1229 UCAACAGACCUCAAAUAGGTT CCUAUUUGAGGUCUGUUGATT 13444.3
S1230 CAGACCUCAAAUAGGCGUUTT AACGCCUAUUUGAGGUCUGTT 13459.4
S1231 AUAGGCGUUGUAAGAGAAUTT AUUCUCUUACAACGCCUAUTT 13429.2
S1232 UAGGCGUUGUAAGAGAAUUTT AAUUCUCUUACAACGCCUATT 13429.2
S1233 GAGAAUUUCUUACACGCAATT UUGCGUGUAAGAAAUUCUCTT 13429.2
S1234 UUUCUUACACGCAAUCCUGTT CAGGAUUGCGUGUAAGAAATT 13444.3
S1235 UCCUGCUUGGAGAAAAGCUTT AGCUUUUCUCCAAGCAGGATT 13459.4
S1236 AAGCUGUUUUUAUCUCACCTT GGUGAGAUAAAAACAGCUUTT 13429.2
S1237 AGCUGUUUUUAUCUCACCUTT AGGUGAGAUAAAAACAGCUTT 13429.2
S1238 GCUGUUUUUAUCUCACCUUTT AAGGUGAGAUAAAAACAGCTT 13429.2
S1239 UUCACAGAACGCUGUAGCUTT AGCUACAGCGUUCUGUGAATT 13459.4
S1240 CGCUGUAGCUUCAAAAAUCTT GAUUUUUGAAGCUACAGCGTT 13444.3
S1241 AAAUCUUAGGAUUGCCUACTT GUAGGCAAUCCUAAGAUUUTT 13429.2
S1242 AAUCUUAGGAUUGCCUACGTT CGUAGGCAAUCCUAAGAUUTT 13444.3
S1243 AUCUUAGGAUUGCCUACGCTT GCGUAGGCAAUCCUAAGAUTT 13459.4
S1244 UCUUAGGAUUGCCUACGCATT UGCGUAGGCAAUCCUAAGATT 13459.4
S1245 ACUACUGAAACAGCACACUTT AGUGUGCUGUUUCAGUAGUTT 13444.3
S1246 CUACUGAAACAGCACACUCTT GAGUGUGCUGUUUCAGUAGTT 13459.4
S1247 ACAGCACACUCUUGUAAUGTT CAUUACAAGAGUGUGCUGUTT 13444.3
S1248 CAGCACACUCUUGUAAUGUTT ACAUUACAAGAGUGUGCUGTT 13444.3
S1249 UGUCAACCGCUUCAAUGUGTT CACAUUGAAGCGGUUGACATT 13459.4
S1250 CCGCUUCAAUGUGGCUAUCTT GAUAGCCACAUUGAAGCGGTT 13474.5
S1251 UGUGGCUAUCACAAGGGCATT UGCCCUUGUGAUAGCCACATT 13474.5
S1252 GGGCAAAAAUUGGCAUUUUTT AAAAUGCCAAUUUUUGCCCTT 13429.2
S1253 AAAUUGGCAUUUUGUGCAUTT AUGCACAAAAUGCCAAUUUTT 13414.1
S1254 AAUUGGCAUUUUGUGCAUATT UAUGCACAAAAUGCCAAUUTT 13414.1
S1255 AUUGGCAUUUUGUGCAUAATT UUAUGCACAAAAUGCCAAUTT 13414.1
S1256 UUGGCAUUUUGUGCAUAAUTT AUUAUGCACAAAAUGCCAATT 13414.1
S1257 UGUCUGAUAGAGAUCUUUATT UAAAGAUCUCUAUCAGACATT 13414.1
S1258 ACUGCAAUUUACAAGUCUATT UAGACUUGUAAAUUGCAGUTT 13414.1
S1259 CUGCAAUUUACAAGUCUAGTT CUAGACUUGUAAAUUGCAGTT 13429.2
S1260 GUCUAGAAAUACCACGUCGTT CGACGUGGUAUUUCUAGACTT 13459.4
S1261 AUACCACGUCGCAAUGUGGTT CCACAUUGCGACGUGGUAUTT 13474.5
S1262 UACCACGUCGCAAUGUGGCTT GCCACAUUGCGACGUGGUATT 13489.6
S1263 UGUGGCUACAUUACAAGCATT UGCUUGUAAUGUAGCCACATT 13444.3
S1264 GCAGAAAAUGUAACUGGACTT GUCCAGUUACAUUUUCUGCTT 13444.3
S1265 UGUAACUGGACUUUUUAAGTT CUUAAAAAGUCCAGUUACATT 13414.1
S1266 CUGGACUUUUUAAGGACUGTT CAGUCCUUAAAAAGUCCAGTT 13444.3
S1267 GGACUGUAGUAAGAUCAUUTT AAUGAUCUUACUACAGUCCTT 13429.2
S1268 GAUCAUUACUGGUCUUCAUTT AUGAAGACCAGUAAUGAUCTT 13429.2
S1269 AGUUCAAGACUGAAGGAUUTT AAUCCUUCAGUCUUGAACUTT 13429.2
S1270 GUUCAAGACUGAAGGAUUATT UAAUCCUUCAGUCUUGAACTT 13429.2
S1271 GACUGAAGGAUUAUGUGUUTT AACACAUAAUCCUUCAGUCTT 13429.2
S1272 GGAUUAUGUGUUGACAUACTT GUAUGUCAACACAUAAUCCTT 13429.2
S1273 AGGACAUGACCUACCGUAGTT CUACGGUAGGUCAUGUCCUTT 13474.5
S1274 GGACAUGACCUACCGUAGATT UCUACGGUAGGUCAUGUCCTT 13474.5
S1275 AUGAAUUACCAAGUCAAUGTT CAUUGACUUGGUAAUUCAUTT 13414.1
S1276 UGAAUUACCAAGUCAAUGGTT CCAUUGACUUGGUAAUUCATT 13429.2
S1277 UUACCAAGUCAAUGGUUACTT GUAACCAUUGACUUGGUAATT 13429.2
S1278 GUCAAUGGUUACCCUAAUATT UAUUAGGGUAACCAUUGACTT 13429.2
S1279 UGGUUACCCUAAUAUGUUUTT AAACAUAUUAGGGUAACCATT 13414.1
S1280 UAUGUUUAUCACCCGCGAATT UUCGCGGGUGAUAAACAUATT 13444.3
S1281 GAAGCUAUUCGUCACGUUCTT GAACGUGACGAAUAGCUUCTT 13459.4
S1282 GCUAUUCGUCACGUUCGUGTT CACGAACGUGACGAAUAGCTT 13474.5
S1283 CUAGAGAUGCUGUGGGUACTT GUACCCACAGCAUCUCUAGTT 13474.5
S1284 CUUAGUAGCUGUACCGACUTT AGUCGGUACAGCUACUAAGTT 13459.4
S1285 AAUAACACAGAAUUCACCATT UGGUGAAUUCUGUGUUAUUTT 13414.1
S1286 AUAACACAGAAUUCACCAGTT CUGGUGAAUUCUGUGUUAUTT 13429.2
S1287 UAACACAGAAUUCACCAGATT UCUGGUGAAUUCUGUGUUATT 13429.2
S1288 CACAGAAUUCACCAGAGUUTT AACUCUGGUGAAUUCUGUGTT 13444.3
S1289 UUCACCAGAGUUAAUGCAATT UUGCAUUAACUCUGGUGAATT 13429.2
S1290 UGCAAAACCUCCACCAGGUTT ACCUGGUGGAGGUUUUGCATT 13474.5
S1291 AACCUCCACCAGGUGACCATT UGGUCACCUGGUGGAGGUUTT 13489.6
S1292 ACCUCCACCAGGUGACCAGTT CUGGUCACCUGGUGGAGGUTT 13504.7
S1293 CCUCCACCAGGUGACCAGUTT ACUGGUCACCUGGUGGAGGTT 13504.7
S1294 ACAUCUUAUACCACUCAUGTT CAUGAGUGGUAUAAGAUGUTT 13429.2
S1295 CAUCUUAUACCACUCAUGUTT ACAUGAGUGGUAUAAGAUGTT 13429.2
S1296 AGGCUUGCCCUGGAAUGUATT UACAUUCCAGGGCAAGCCUTT 13474.5
S1297 GGCUUGCCCUGGAAUGUAGTT CUACAUUCCAGGGCAAGCCTT 13489.6
S1298 UGUAGUGCGUAUUAAGAUATT UAUCUUAAUACGCACUACATT 13414.1
S1299 GAUAGUACAAAUGCUCAGUTT ACUGAGCAUUUGUACUAUCTT 13429.2
S1300 AUGCUCAGUGAUACACUGATT UCAGUGUAUCACUGAGCAUTT 13444.3
S1301 UGCUCAGUGAUACACUGAATT UUCAGUGUAUCACUGAGCATT 13444.3
S1302 AGGAUUGUCAGACAGAGUCTT GACUCUGUCUGACAAUCCUTT 13459.4
S1303 GGAUUGUCAGACAGAGUCGTT CGACUCUGUCUGACAAUCCTT 13474.5
S1304 UGAAGUACUUUGUCAAGAUTT AUCUUGACAAAGUACUUCATT 13414.1
S1305 GUACUUUGUCAAGAUUGGATT UCCAAUCUUGACAAAGUACTT 13429.2
S1306 GAUUGGACCUGAAAGAACGTT CGUUCUUUCAGGUCCAAUCTT 13459.4
S1307 AGAACGUGUUGUCUGUGUGTT CACACAGACAACACGUUCUTT 13459.4
S1308 GAACGUGUUGUCUGUGUGATT UCACACAGACAACACGUUCTT 13459.4
S1309 CGUGUUGUCUGUGUGACAATT UUGUCACACAGACAACACGTT 13459.4
S1310 ACGUGCAACUUGCUUUUCUTT AGAAAAGCAAGUUGCACGUTT 13444.3
S1311 CGUGCAACUUGCUUUUCUATT UAGAAAAGCAAGUUGCACGTT 13444.3
S1312 CUUGCUUUUCUACUUCAUCTT GAUGAAGUAGAAAAGCAAGTT 13429.2
S1313 UCAUUCUGUGGGUUUUGACTT GUCAAAACCCACAGAAUGATT 13444.3
S1314 CCCAUUUAUGAUUGAUGUUTT AACAUCAAUCAUAAAUGGGTT 13414.1
S1315 CCUUCAGAGUAACCAUGACTT GUCAUGGUUACUCUGAAGGTT 13459.4
S1316 CCAUGACCAACAUUGCCAGTT CUGGCAAUGUUGGUCAUGGTT 13474.5
S1317 CAUUGCCAGGUACAUGGAATT UUCCAUGUACCUGGCAAUGTT 13459.4
S1318 AUGCACAUGUGGCUAGUUGTT CAACUAGCCACAUGUGCAUTT 13459.4
S1319 UGCACAUGUGGCUAGUUGUTT ACAACUAGCCACAUGUGCATT 13459.4
S1320 GCGCGUUGAUUGGUCUGUUTT AACAGACCAAUCAACGCGCTT 13474.5
S1321 UACCCUAUUAUAGGAGAUGTT CAUCUCCUAUAAUAGGGUATT 13429.2
S1322 CUGAGGGUUAAUUCUGCUUTT AAGCAGAAUUAACCCUCAGTT 13444.3
S1323 UUCUGCUUGCAGAAAAGUATT UACUUUUCUGCAAGCAGAATT 13429.2
S1324 AAGUACAACACAUGGUUGUTT ACAACCAUGUGUUGUACUUTT 13429.2
S1325 AGUACAACACAUGGUUGUGTT CACAACCAUGUGUUGUACUTT 13444.3
S1326 GUACAACACAUGGUUGUGATT UCACAACCAUGUGUUGUACTT 13444.3
S1327 CACAUGGUUGUGAAGUCUGTT CAGACUUCACAACCAUGUGTT 13459.4
S1328 GUCUGCAUUGCUUGCUGAUTT AUCAGCAAGCAAUGCAGACTT 13459.4
S1329 GUUUCCAGUUCUUCAUGACTT GUCAUGAAGAACUGGAAACTT 13444.3
S1330 AUCCAAAGGCUAUCAAGUGTT CACUUGAUAGCCUUUGGAUTT 13444.3
S1331 UCCAAAGGCUAUCAAGUGUTT ACACUUGAUAGCCUUUGGATT 13444.3
S1332 AGGCUAUCAAGUGUGUGCCTT GGCACACACUUGAUAGCCUTT 13474.5
S1333 GGCUAUCAAGUGUGUGCCUTT AGGCACACACUUGAUAGCCTT 13474.5
S1334 GUGUGUGCCUCAGGCUGAATT UUCAGCCUGAGGCACACACTT 13489.6
S1335 GUAGAAUGGAAGUUCUACGTT CGUAGAACUUCCAUUCUACTT 13444.3
S1336 UGGAAGUUCUACGAUGCUCTT GAGCAUCGUAGAACUUCCATT 13459.4
S1337 GUUCUACGAUGCUCAGCCATT UGGCUGAGCAUCGUAGAACTT 13474.5
S1338 AGCUUACAAAAUAGAGGAATT UUCCUCUAUUUUGUAAGCUTT 13414.1
S1339 GCUUACAAAAUAGAGGAACTT GUUCCUCUAUUUUGUAAGCTT 13429.2
S1340 AAUAGAGGAACUCUUCUAUTT AUAGAAGAGUUCCUCUAUUTT 13414.1
S1341 AUAGAGGAACUCUUCUAUUTT AAUAGAAGAGUUCCUCUAUTT 13414.1
S1342 UAGAGGAACUCUUCUAUUCTT GAAUAGAAGAGUUCCUCUATT 13429.2
S1343 CUCUUCUAUUCUUAUGCUATT UAGCAUAAGAAUAGAAGAGTT 13414.1
S1344 AUUCACUGAUGGUGUUUGUTT ACAAACACCAUCAGUGAAUTT 13429.2
S1345 UUCACUGAUGGUGUUUGUUTT AACAAACACCAUCAGUGAATT 13429.2
S1346 UUGUAACGUUGAUCGUUACTT GUAACGAUCAACGUUACAATT 13429.2
S1347 CGUUGAUCGUUACCCAGCCTT GGCUGGGUAACGAUCAACGTT 13489.6
S1348 UGCAAUUGUGUGUAGGUUUTT AAACCUACACACAAUUGCATT 13429.2
S1349 UUGUGUGUAGGUUUGACACTT GUGUCAAACCUACACACAATT 13444.3
S1350 GAGUCUUGUCAAACUUGAATT UUCAAGUUUGACAAGACUCTT 13429.2
S1351 ACUUGAACUUACCAGGCUGTT CAGCCUGGUAAGUUCAAGUTT 13459.4
S1352 CUUGAACUUACCAGGCUGUTT ACAGCCUGGUAAGUUCAAGTT 13459.4
S1353 CUUACCAGGCUGUGAUGGUTT ACCAUCACAGCCUGGUAAGTT 13474.5
S1354 UAAGCAUGCAUUCCACACUTT AGUGUGGAAUGCAUGCUUATT 13444.3
S1355 GCAUGCAUUCCACACUCCATT UGGAGUGUGGAAUGCAUGCTT 13474.5
S1356 UUUAAAGCAAUUGCCUUUCTT GAAAGGCAAUUGCUUUAAATT 13414.1
S1357 AGCAAUUGCCUUUCUUUUATT UAAAAGAAAGGCAAUUGCUTT 13414.1
S1358 GCAAUUGCCUUUCUUUUACTT GUAAAAGAAAGGCAAUUGCTT 13429.2
S1359 ACAAGUAGUGUCGGAUAUUTT AAUAUCCGACACUACUUGUTT 13429.2
S1360 CAAGUAGUGUCGGAUAUUGTT CAAUAUCCGACACUACUUGTT 13444.3
S1361 GUAGUGUCGGAUAUUGAUUTT AAUCAAUAUCCGACACUACTT 13429.2
S1362 AUCUGCUACGUGUAUUACATT UGUAAUACACGUAGCAGAUTT 13429.2
S1363 UCUGCUACGUGUAUUACACTT GUGUAAUACACGUAGCAGATT 13444.3
S1364 UUUAGGUGGUGCUGUUUGCTT GCAAACAGCACCACCUAAATT 13459.4
S1365 AUGAGUACCGACAGUACUUTT AAGUACUGUCGGUACUCAUTT 13444.3
S1366 UGAGUACCGACAGUACUUGTT CAAGUACUGUCGGUACUCATT 13459.4
S1367 UAUGAUGAUUUCUGCUGGATT UCCAGCAGAAAUCAUCAUATT 13429.2
S1368 CCUGUGGAAUACAUUUACCTT GGUAAAUGUAUUCCACAGGTT 13444.3
S1369 UACAUUUACCAGGUUACAGTT CUGUAACCUGGUAAAUGUATT 13429.2
S1370 AAUGUGGCUUAUAAUGUUGTT CAACAUUAUAAGCCACAUUTT 13414.1
S1371 AUGUGGCUUAUAAUGUUGUTT ACAACAUUAUAAGCCACAUTT 13414.1
S1372 UGUGGCUUAUAAUGUUGUUTT AACAACAUUAUAAGCCACATT 13414.1
S1373 UGUUGUUAAUAAAGGACACTT GUGUCCUUUAUUAACAACATT 13414.1
S1374 UAAAGGACACUUUGAUGGATT UCCAUCAAAGUGUCCUUUATT 13429.2
S1375 AGGACACUUUGAUGGACACTT GUGUCCAUCAAAGUGUCCUTT 13459.4
S1376 GGACACUUUGAUGGACACGTT CGUGUCCAUCAAAGUGUCCTT 13474.5
S1377 GCACCUGUUUCCAUCAUUATT UAAUGAUGGAAACAGGUGCTT 13444.3
S1378 UAAUGCUGUUUACACAAAGTT CUUUGUGUAAACAGCAUUATT 13414.1
S1379 UGCUGUUUACACAAAGGUATT UACCUUUGUGUAAACAGCATT 13429.2
S1380 AGGUAGAUGGUAUUGAUGUTT ACAUCAAUACCAUCUACCUTT 13429.2
S1381 GGUAGAUGGUAUUGAUGUGTT CACAUCAAUACCAUCUACCTT 13444.3
S1382 AAUAAGACAACACUUCCUGTT CAGGAAGUGUUGUCUUAUUTT 13429.2
S1383 AUAAGACAACACUUCCUGUTT ACAGGAAGUGUUGUCUUAUTT 13429.2
S1384 UAAGACAACACUUCCUGUUTT AACAGGAAGUGUUGUCUUATT 13429.2
S1385 GACAACACUUCCUGUUAAUTT AUUAACAGGAAGUGUUGUCTT 13429.2
S1386 CACUUCCUGUUAAUGUUGCTT GCAACAUUAACAGGAAGUGTT 13444.3
S1387 UGUUGCAUUUGAGCUUUGGTT CCAAAGCUCAAAUGCAACATT 13444.3
S1388 GCGUAACAUUAAACCAGUGTT CACUGGUUUAAUGUUACGCTT 13444.3
S1389 CAUUAAACCAGUGCCAGAGTT CUCUGGCACUGGUUUAAUGTT 13459.4
S1390 ACCAGUGCCAGAGAUUAAGTT CUUAAUCUCUGGCACUGGUTT 13459.4
S1391 CCAGUGCCAGAGAUUAAGATT UCUUAAUCUCUGGCACUGGTT 13459.4
S1392 GAUACUCAAUAAUUUGGGUTT ACCCAAAUUAUUGAGUAUCTT 13414.1
S1393 UAAUUUGGGUGUUGAUAUCTT GAUAUCAACACCCAAAUUATT 13414.1
S1394 UUUGGGUGUUGAUAUCGCUTT AGCGAUAUCAACACCCAAATT 13444.3
S1395 UACUGUAAUCUGGGACUACTT GUAGUCCCAGAUUACAGUATT 13444.3
S1396 UCUGGGACUACAAAAGAGATT UCUCUUUUGUAGUCCCAGATT 13444.3
S1397 AAGAGAAGCCCCAGCACAUTT AUGUGCUGGGGCUUCUCUUTT 13474.5
S1398 AGAGAAGCCCCAGCACAUGTT CAUGUGCUGGGGCUUCUCUTT 13489.6
S1399 GAGAAGCCCCAGCACAUGUTT ACAUGUGCUGGGGCUUCUCTT 13489.6
S1400 GCCCCAGCACAUGUAUCUATT UAGAUACAUGUGCUGGGGCTT 13474.5
S1401 UAGGUGUCUGCACAAUGACTT GUCAUUGUGCAGACACCUATT 13459.4
S1402 UGACUGACAUUGCCAAGAATT UUCUUGGCAAUGUCAGUCATT 13444.3
S1403 GAAACCUACUGAGAGUGCUTT AGCACUCUCAGUAGGUUUCTT 13459.4
S1404 ACCUACUGAGAGUGCUUGUTT ACAAGCACUCUCAGUAGGUTT 13459.4
S1405 CCUACUGAGAGUGCUUGUUTT AACAAGCACUCUCAGUAGGTT 13459.4
S1406 GGACAGGUAGACCUUUUUATT UAAAAAGGUCUACCUGUCCTT 13444.3
S1407 ACGCCCGUAAUGGUGUUUUTT AAAACACCAUUACGGGCGUTT 13459.4
S1408 CGCCCGUAAUGGUGUUUUATT UAAAACACCAUUACGGGCGTT 13459.4
S1409 UAACAGAAGGUUCAGUCAATT UUGACUGAACCUUCUGUUATT 13429.2
S1410 CAGAAGGUUCAGUCAAAGGTT CCUUUGACUGAACCUUCUGTT 13459.4
S1411 GGUUCAGUCAAAGGUCUAATT UUAGACCUUUGACUGAACCTT 13444.3
S1412 AGGUCUAACACCUUCAAAGTT CUUUGAAGGUGUUAGACCUTT 13444.3
S1413 GGUCUAACACCUUCAAAGGTT CCUUUGAAGGUGUUAGACCTT 13459.4
S1414 AGGGACCAGCACAAGCUAGTT CUAGCUUGUGCUGGUCCCUTT 13489.6
S1415 GGGACCAGCACAAGCUAGCTT GCUAGCUUGUGCUGGUCCCTT 13504.7
S1416 GCUAGCGUCAAUGGAGUCATT UGACUCCAUUGACGCUAGCTT 13474.5
S1417 UGGAGUCACAUUAAUUGGATT UCCAAUUAAUGUGACUCCATT 13429.2
S1418 UUGGAGAAUCAGUAAAAACTT GUUUUUACUGAUUCUCCAATT 13414.1
S1419 CUACUUUAAGAAAGUAGACTT GUCUACUUUCUUAAAGUAGTT 13414.1
S1420 GAAAGUAGACGGCAUUAUUTT AAUAAUGCCGUCUACUUUCTT 13429.2
S1421 AGUAGACGGCAUUAUUCAATT UUGAAUAAUGCCGUCUACUTT 13429.2
S1422 GUAGACGGCAUUAUUCAACTT GUUGAAUAAUGCCGUCUACTT 13444.3
S1423 CAGUUGCCUGAAACCUACUTT AGUAGGUUUCAGGCAACUGTT 13459.4
S1424 ACCUACUUUACUCAGAGCATT UGCUCUGAGUAAAGUAGGUTT 13444.3
S1425 CCUACUUUACUCAGAGCAGTT CUGCUCUGAGUAAAGUAGGTT 13459.4
S1426 GCCCAGAUCACAAAUGGAATT UUCCAUUUGUGAUCUGGGCTT 13459.4
S1427 AUGGAAACUGACUUUCUCGTT CGAGAAAGUCAGUUUCCAUTT 13444.3
S1428 UGGAAACUGACUUUCUCGATT UCGAGAAAGUCAGUUUCCATT 13444.3
S1429 ACUGACUUUCUCGAGCUCGTT CGAGCUCGAGAAAGUCAGUTT 13474.5
S1430 CUGACUUUCUCGAGCUCGCTT GCGAGCUCGAGAAAGUCAGTT 13489.6
S1431 UUCAUACAGCGAUAUAAGCTT GCUUAUAUCGCUGUAUGAATT 13429.2
S1432 GCUCGAGGGCUAUGCCUUCTT GAAGGCAUAGCCCUCGAGCTT 13504.7
S1433 CACAUCGUUUAUGGAGAUUTT AAUCUCCAUAAACGAUGUGTT 13429.2
S1434 CUUGGCGGUCUUCAUUUAATT UUAAAUGAAGACCGCCAAGTT 13444.3
S1435 UGAUAGGCUUAGCCAAGCGTT CGCUUGGCUAAGCCUAUCATT 13474.5
S1436 GCGCUCACAAGAUUCACCATT UGGUGAAUCUUGUGAGCGCTT 13474.5
S1437 GAUUCACCACUUAAAUUAGTT CUAAUUUAAGUGGUGAAUCTT 13414.1
S1438 AUUAGAGGAUUUUAUCCCUTT AGGGAUAAAAUCCUCUAAUTT 13414.1
S1439 UUAGAGGAUUUUAUCCCUATT UAGGGAUAAAAUCCUCUAATT 13414.1
S1440 AUUACUUCAUAACAGAUGCTT GCAUCUGUUAUGAAGUAAUTT 13414.1
S1441 UUACUUCAUAACAGAUGCGTT CGCAUCUGUUAUGAAGUAATT 13429.2
S1442 CAGAUGCGCAAACAGGUUCTT GAACCUGUUUGCGCAUCUGTT 13474.5
S1443 ACAGGUUCAUCAAAAUGUGTT CACAUUUUGAUGAACCUGUTT 13429.2
S1444 CAGGUUCAUCAAAAUGUGUTT ACACAUUUUGAUGAACCUGTT 13429.2
S1445 AAUGUGUGUGUUCUGUGAUTT AUCACAGAACACACACAUUTT 13429.2
S1446 AUGUGUGUGUUCUGUGAUUTT AAUCACAGAACACACACAUTT 13429.2
S1447 UGUGUGUGUUCUGUGAUUGTT CAAUCACAGAACACACACATT 13444.3
S1448 UAAAGUCACAAGAUUUGUCTT GACAAAUCUUGUGACUUUATT 13414.1
S1449 AGUCACAAGAUUUGUCAGUTT ACUGACAAAUCUUGUGACUTT 13429.2
S1450 GUCACAAGAUUUGUCAGUGTT CACUGACAAAUCUUGUGACTT 13444.3
S1451 GAUUUGUCAGUGAUUUCAATT UUGAAAUCACUGACAAAUCTT 13414.1
S1452 AAGUGGUCAAGGUUACAAUTT AUUGUAACCUUGACCACUUTT 13429.2
S1453 AGUGGUCAAGGUUACAAUUTT AAUUGUAACCUUGACCACUTT 13429.2
S1454 GUGGUCAAGGUUACAAUUGTT CAAUUGUAACCUUGACCACTT 13444.3
S1455 GGUUACAAUUGACUAUGCUTT AGCAUAGUCAAUUGUAACCTT 13429.2
S1456 UUGACUAUGCUGAAAUUUCTT GAAAUUUCAGCAUAGUCAATT 13414.1
S1457 AUUUCAUUCAUGCUUUGGUTT ACCAAAGCAUGAAUGAAAUTT 13414.1
S1458 UUUCAUUCAUGCUUUGGUGTT CACCAAAGCAUGAAUGAAATT 13429.2
S1459 GGAUGGACAUGUUGAAACCTT GGUUUCAACAUGUCCAUCCTT 13459.4
S1460 ACCUUCUACCCAAAACUACTT GUAGUUUUGGGUAGAAGGUTT 13444.3
S1461 CCUUCUACCCAAAACUACATT UGUAGUUUUGGGUAGAAGGTT 13444.3
S1462 AACUACAAGCAAGUCGAGCTT GCUCGACUUGCUUGUAGUUTT 13459.4
S1463 ACUACAAGCAAGUCGAGCGTT CGCUCGACUUGCUUGUAGUTT 13474.5
S1464 CUACAAGCAAGUCGAGCGUTT ACGCUCGACUUGCUUGUAGTT 13474.5
S1465 GCAAGUCGAGCGUGGCAACTT GUUGCCACGCUCGACUUGCTT 13504.7
S1466 GUCGAGCGUGGCAACCAGGTT CCUGGUUGCCACGCUCGACTT 13519.8
S1467 CCAGGUGUUGCGAUGCCUATT UAGGCAUCGCAACACCUGGTT 13489.6
S1468 CUUGUACAAGAUGCAAAGATT UCUUUGCAUCUUGUACAAGTT 13429.2
S1469 GAUGCAAAGAAUGCUUCUUTT AAGAAGCAUUCUUUGCAUCTT 13429.2
S1470 AGAAUGCUUCUUGAAAAGUTT ACUUUUCAAGAAGCAUUCUTT 13414.1
S1471 GAAUGCUUCUUGAAAAGUGTT CACUUUUCAAGAAGCAUUCTT 13429.2
S1472 UGCUUCUUGAAAAGUGUGATT UCACACUUUUCAAGAAGCATT 13429.2
S1473 AAGUGUGACCUUCAGAAUUTT AAUUCUGAAGGUCACACUUTT 13429.2
S1474 AGUGUGACCUUCAGAAUUATT UAAUUCUGAAGGUCACACUTT 13429.2
S1475 GUGUGACCUUCAGAAUUAUTT AUAAUUCUGAAGGUCACACTT 13429.2
S1476 UUAUGGUGAAAAUGCUGUUTT AACAGCAUUUUCACCAUAATT 13414.1
S1477 AAUGCUGUUAUACCAAAAGTT CUUUUGGUAUAACAGCAUUTT 13414.1
S1478 AUGCUGUUAUACCAAAAGGTT CCUUUUGGUAUAACAGCAUTT 13429.2
S1479 UGCUGUUAUACCAAAAGGATT UCCUUUUGGUAUAACAGCATT 13429.2
S1480 AGGAAUAAUGAUGAAUGUCTT GACAUUCAUCAUUAUUCCUTT 13414.1
S1481 GGAAUAAUGAUGAAUGUCGTT CGACAUUCAUCAUUAUUCCTT 13429.2
S1482 UAAUGAUGAAUGUCGCAAATT UUUGCGACAUUCAUCAUUATT 13414.1
S1483 UGAUGAAUGUCGCAAAGUATT UACUUUGCGACAUUCAUCATT 13429.2
S1484 UGUCGCAAAGUAUACUCAATT UUGAGUAUACUUUGCGACATT 13429.2
S1485 AGUAUACUCAACUGUGUCATT UGACACAGUUGAGUAUACUTT 13429.2
S1486 GUAUACUCAACUGUGUCAATT UUGACACAGUUGAGUAUACTT 13429.2
S1487 AUACACUUACUUUAGCUGUTT ACAGCUAAAGUAAGUGUAUTT 13414.1
S1488 UACACUUACUUUAGCUGUATT UACAGCUAAAGUAAGUGUATT 13414.1
S1489 CAUGAGAGUUAUUCACUUUTT AAAGUGAAUAACUCUCAUGTT 13414.1
S1490 AGGAGUUGCACCAGGUACATT UGUACCUGGUGCAACUCCUTT 13474.5
S1491 GGAGUUGCACCAGGUACAGTT CUGUACCUGGUGCAACUCCTT 13489.6
S1492 UGGUUGCCAACUGGCACACTT GUGUGCCAGUUGGCAACCATT 13489.6
S1493 CUGGCACACUACUUGUCGATT UCGACAAGUAGUGUGCCAGTT 13474.5
S1494 UGACUUCGUCUCCGACGCATT UGCGUCGGAGACGAAGUCATT 13489.6
S1495 UUGGAGACUGUGCAACAGUTT ACUGUUGCACAGUCUCCAATT 13459.4
S1496 CAGUACAUACGGCUAAUAATT UUAUUAGCCGUAUGUACUGTT 13429.2
S1497 AUGGGACCUUAUUAUUAGCTT GCUAAUAAUAAGGUCCCAUTT 13429.2
S1498 UGGGACCUUAUUAUUAGCGTT CGCUAAUAAUAAGGUCCCATT 13444.3
S1499 ACAUGUGACAAAAGAGAAUTT AUUCUCUUUUGUCACAUGUTT 13414.1
S1500 CAUGUGACAAAAGAGAAUGTT CAUUCUCUUUUGUCACAUGTT 13429.2
S1501 AAGAGAAUGACUCUAAAGATT UCUUUAGAGUCAUUCUCUUTT 13414.1
S1502 AGAGAAUGACUCUAAAGAATT UUCUUUAGAGUCAUUCUCUTT 13414.1
S1503 GAGAAUGACUCUAAAGAAGTT CUUCUUUAGAGUCAUUCUCTT 13429.2
S1504 UGACUCUAAAGAAGGGUUUTT AAACCCUUCUUUAGAGUCATT 13429.2
S1505 AGAAGGGUUUUUCACUUAUTT AUAAGUGAAAAACCCUUCUTT 13414.1
S1506 GAAGGGUUUUUCACUUAUCTT GAUAAGUGAAAAACCCUUCTT 13429.2
S1507 GGGUUUUUCACUUAUCUGUTT ACAGAUAAGUGAAAAACCCTT 13429.2
S1508 AGCAAAAACUAGCCCUGGGTT CCCAGGGCUAGUUUUUGCUTT 13474.5
S1509 GCAAAAACUAGCCCUGGGUTT ACCCAGGGCUAGUUUUUGCTT 13474.5
S1510 AAACUAGCCCUGGGUGGUUTT AACCACCCAGGGCUAGUUUTT 13474.5
S1511 AACUAGCCCUGGGUGGUUCTT GAACCACCCAGGGCUAGUUTT 13489.6
S1512 ACUAGCCCUGGGUGGUUCUTT AGAACCACCCAGGGCUAGUTT 13489.6
S1513 CUAGCCCUGGGUGGUUCUATT UAGAACCACCCAGGGCUAGTT 13489.6
S1514 AGAUAACAGAGCAUUCUUGTT CAAGAAUGCUCUGUUAUCUTT 13429.2
S1515 GAUAACAGAGCAUUCUUGGTT CCAAGAAUGCUCUGUUAUCTT 13444.3
S1516 CAGAGCAUUCUUGGAAUGCTT GCAUUCCAAGAAUGCUCUGTT 13459.4
S1517 UGCUGACCUUUACAAGCUUTT AAGCUUGUAAAGGUCAGCATT 13444.3
S1518 GCUUAUGGGCCAUUUCUCATT UGAGAAAUGGCCCAUAAGCTT 13459.4
S1519 AUGUAAAUGCAUCAUCAUCTT GAUGAUGAUGCAUUUACAUTT 13414.1
S1520 UGUAAAUGCAUCAUCAUCGTT CGAUGAUGAUGCAUUUACATT 13429.2
S1521 AUGCAUCAUCAUCGGAAGCTT GCUUCCGAUGAUGAUGCAUTT 13459.4
S1522 UGCAUCAUCAUCGGAAGCATT UGCUUCCGAUGAUGAUGCATT 13459.4
S1523 GCAUUUUUAAUUGGGGCUATT UAGCCCCAAUUAAAAAUGCTT 13429.2
S1524 UUGGGGCUAACUAUCUUGGTT CCAAGAUAGUUAGCCCCAATT 13459.4
S1525 CUAUCUUGGCAAGCCGAAGTT CUUCGGCUUGCCAAGAUAGTT 13474.5
S1526 GCCGAAGGAACAAAUUGAUTT AUCAAUUUGUUCCUUCGGCTT 13444.3
S1527 GGAACAAAUUGAUGGCUAUTT AUAGCCAUCAAUUUGUUCCTT 13429.2
S1528 CAAAUUGAUGGCUAUACCATT UGGUAUAGCCAUCAAUUUGTT 13429.2
S1529 AUUGAUGGCUAUACCAUGCTT GCAUGGUAUAGCCAUCAAUTT 13444.3
S1530 UUGAUGGCUAUACCAUGCATT UGCAUGGUAUAGCCAUCAATT 13444.3
S1531 CUACAUUUUCUGGAGGAACTT GUUCCUCCAGAAAAUGUAGTT 13444.3
S1532 CACAAAUCCUAUCCAGUUGTT CAACUGGAUAGGAUUUGUGTT 13444.3
S1533 AUCCUAUCCAGUUGUCUUCTT GAAGACAACUGGAUAGGAUTT 13444.3
S1534 UCCUAUCCAGUUGUCUUCCTT GGAAGACAACUGGAUAGGATT 13459.4
S1535 AUUAAGAGGAACUGCUGUATT UACAGCAGUUCCUCUUAAUTT 13429.2
S1536 UUAAGAGGAACUGCUGUAATT UUACAGCAGUUCCUCUUAATT 13429.2
S1537 GAGGAACUGCUGUAAUGUCTT GACAUUACAGCAGUUCCUCTT 13459.4
S1538 CUGCUGUAAUGUCUCUUAATT UUAAGAGACAUUACAGCAGTT 13429.2
S1539 UGUCUCUUAAGGAGAAUCATT UGAUUCUCCUUAAGAGACATT 13429.2
S1540 GGAGAAUCAAAUCAAUGAUTT AUCAUUGAUUUGAUUCUCCTT 13414.1
S1541 AAAGGUAGGCUUAUCAUUATT UAAUGAUAAGCCUACCUUUTT 13414.1
S1542 AAGGUAGGCUUAUCAUUAGTT CUAAUGAUAAGCCUACCUUTT 13429.2
S1543 AGGUAGGCUUAUCAUUAGATT UCUAAUGAUAAGCCUACCUTT 13429.2
S1544 GGUAGGCUUAUCAUUAGAGTT CUCUAAUGAUAAGCCUACCTT 13444.3
S1545 AACAACAGAGUUGUGGUUUTT AAACCACAACUCUGUUGUUTT 13429.2
S1546 ACAACAGAGUUGUGGUUUCTT GAAACCACAACUCUGUUGUTT 13444.3
S1547 CAACAGAGUUGUGGUUUCATT UGAAACCACAACUCUGUUGTT 13444.3
S1548 CAGAGUUGUGGUUUCAAGUTT ACUUGAAACCACAACUCUGTT 13444.3
上表中S1-S995SiRNA的目标基因是多功能聚合酶a和多功能聚合酶b,S996-S1548SiRNA的目标基因是多功能聚合酶b。
表4、针对第二编码区的SiRNA分子
序号 正义链序列 反义链序列 MW
S1549 UUACACUCAACAUACUUCATT UGAAGUAUGUUGAGUGUAATT 13414.1
S1550 CAUACUUCAUCUAUGAGGGTT CCCUCAUAGAUGAAGUAUGTT 13444.3
S1551 AUUUUUAGAUCAGACACUCTT GAGUGUCUGAUCUAAAAAUTT 13414.1
S1552 UUUUUAGAUCAGACACUCUTT AGAGUGUCUGAUCUAAAAATT 13414.1
S1553 UGUUACAGGGUUUCAUACUTT AGUAUGAAACCCUGUAACATT 13429.2
S1554 UCAUACGUUUGGCAACCCUTT AGGGUUGCCAAACGUAUGATT 13459.4
S1555 CCCUGUCAUACCUUUUAAGTT CUUAAAAGGUAUGACAGGGTT 13444.3
S1556 GGAUGGUAUUUAUUUUGCUTT AGCAAAAUAAAUACCAUCCTT 13414.1
S1557 AUCAAAUGUUGUCCGUGGUTT ACCACGGACAACAUUUGAUTT 13444.3
S1558 AUGUUGUCCGUGGUUGGGUTT ACCCAACCACGGACAACAUTT 13474.5
S1559 UGUUGUCCGUGGUUGGGUUTT AACCCAACCACGGACAACATT 13474.5
S1560 UGUUGUUAUACGAGCAUGUTT ACAUGCUCGUAUAACAACATT 13429.2
S1561 CUUUGAAUUGUGUGACAACTT GUUGUCACACAAUUCAAAGTT 13429.2
S1562 UUGUGUGACAACCCUUUCUTT AGAAAGGGUUGUCACACAATT 13444.3
S1563 CCCUUUCUUUGCUGUUUCUTT AGAAACAGCAAAGAAAGGGTT 13444.3
S1564 ACCCAUGGGUACACAGACATT UGUCUGUGUACCCAUGGGUTT 13474.5
S1565 CCCAUGGGUACACAGACACTT GUGUCUGUGUACCCAUGGGTT 13489.6
S1566 UGCAUUUAAUUGCACUUUCTT GAAAGUGCAAUUAAAUGCATT 13414.1
S1567 UUGCACUUUCGAGUACAUATT UAUGUACUCGAAAGUGCAATT 13429.2
S1568 GUCAGGUAAUUUUAAACACTT GUGUUUAAAAUUACCUGACTT 13414.1
S1569 UUUUAAACACUUACGAGAGTT CUCUCGUAAGUGUUUAAAATT 13414.1
S1570 ACACUUACGAGAGUUUGUGTT CACAAACUCUCGUAAGUGUTT 13444.3
S1571 AAUAAAGAUGGGUUUCUCUTT AGAGAAACCCAUCUUUAUUTT 13414.1
S1572 AUAAAGAUGGGUUUCUCUATT UAGAGAAACCCAUCUUUAUTT 13414.1
S1573 UAAAGAUGGGUUUCUCUAUTT AUAGAGAAACCCAUCUUUATT 13414.1
S1574 AGAUGGGUUUCUCUAUGUUTT AACAUAGAGAAACCCAUCUTT 13429.2
S1575 GAUGGGUUUCUCUAUGUUUTT AAACAUAGAGAAACCCAUCTT 13429.2
S1576 GGGCUAUCAACCUAUAGAUTT AUCUAUAGGUUGAUAGCCCTT 13444.3
S1577 ACCUAUUUUUAAGUUGCCUTT AGGCAACUUAAAAAUAGGUTT 13414.1
S1578 CCUAUUUUUAAGUUGCCUCTT GAGGCAACUUAAAAAUAGGTT 13429.2
S1579 CAUUACAAAUUUUAGAGCCTT GGCUCUAAAAUUUGUAAUGTT 13414.1
S1580 AUUUUAGAGCCAUUCUUACTT GUAAGAAUGGCUCUAAAAUTT 13414.1
S1581 UUUUAGAGCCAUUCUUACATT UGUAAGAAUGGCUCUAAAATT 13414.1
S1582 GACAUUUGGGGCACGUCAGTT CUGACGUGCCCCAAAUGUCTT 13489.6
S1583 AGCCAACUACAUUUAUGCUTT AGCAUAAAUGUAGUUGGCUTT 13429.2
S1584 CUACAUUUAUGCUCAAGUATT UACUUGAGCAUAAAUGUAGTT 13414.1
S1585 GUAUGAUGAAAAUGGUACATT UGUACCAUUUUCAUCAUACTT 13414.1
S1586 AAUGGUACAAUCACAGAUGTT CAUCUGUGAUUGUACCAUUTT 13429.2
S1587 AUGGUACAAUCACAGAUGCTT GCAUCUGUGAUUGUACCAUTT 13444.3
S1588 AAUCCACUUGCUGAACUCATT UGAGUUCAGCAAGUGGAUUTT 13444.3
S1589 AUCCACUUGCUGAACUCAATT UUGAGUUCAGCAAGUGGAUTT 13444.3
S1590 CUCAAAUGCUCUGUUAAGATT UCUUAACAGAGCAUUUGAGTT 13429.2
S1591 AUGCUCUGUUAAGAGCUUUTT AAAGCUCUUAACAGAGCAUTT 13429.2
S1592 GAGCUUUGAGAUUGACAAATT UUUGUCAAUCUCAAAGCUCTT 13429.2
S1593 AGGAAUUUACCAGACCUCUTT AGAGGUCUGGUAAAUUCCUTT 13444.3
S1594 UUUACCAGACCUCUAAUUUTT AAAUUAGAGGUCUGGUAAATT 13414.1
S1595 UUUCAGGGUUGUUCCCUCATT UGAGGGAACAACCCUGAAATT 13459.4
S1596 UAUUACAAACUUGUGUCCUTT AGGACACAAGUUUGUAAUATT 13414.1
S1597 ACUUGUGUCCUUUUGGAGATT UCUCCAAAAGGACACAAGUTT 13444.3
S1598 CUUGUGUCCUUUUGGAGAGTT CUCUCCAAAAGGACACAAGTT 13459.4
S1599 UGCUACUAAAUUCCCUUCUTT AGAAGGGAAUUUAGUAGCATT 13429.2
S1600 AUUCCCUUCUGUCUAUGCATT UGCAUAGACAGAAGGGAAUTT 13444.3
S1601 UUCCCUUCUGUCUAUGCAUTT AUGCAUAGACAGAAGGGAATT 13444.3
S1602 AUUUCUAAUUGUGUUGCUGTT CAGCAACACAAUUAGAAAUTT 13414.1
S1603 UUUCUAAUUGUGUUGCUGATT UCAGCAACACAAUUAGAAATT 13414.1
S1604 UUGUGUUGCUGAUUACUCUTT AGAGUAAUCAGCAACACAATT 13429.2
S1605 CUCAACAUUUUUUUCAACCTT GGUUGAAAAAAAUGUUGAGTT 13414.1
S1606 UGAUCUUUGCUUCUCCAAUTT AUUGGAGAAGCAAAGAUCATT 13429.2
S1607 UGUCUAUGCAGAUUCUUUUTT AAAAGAAUCUGCAUAGACATT 13414.1
S1608 GGGAGAUGAUGUAAGACAATT UUGUCUUACAUCAUCUCCCTT 13444.3
S1609 AUAGCGCCAGGACAAACUGTT CAGUUUGUCCUGGCGCUAUTT 13474.5
S1610 ACUGGUGUUAUUGCUGAUUTT AAUCAGCAAUAACACCAGUTT 13429.2
S1611 CUGGUGUUAUUGCUGAUUATT UAAUCAGCAAUAACACCAGTT 13429.2
S1612 AUUGCCAGAUGAUUUCAUGTT CAUGAAAUCAUCUGGCAAUTT 13429.2
S1613 UACUAGGAACAUUGAUGCUTT AGCAUCAAUGUUCCUAGUATT 13429.2
S1614 UAUAGGUAUCUUAGACAUGTT CAUGUCUAAGAUACCUAUATT 13414.1
S1615 GCUUAGGCCCUUUGAGAGATT UCUCUCAAAGGGCCUAAGCTT 13474.5
S1616 UGUGCCUUUCUCCCCUGAUTT AUCAGGGGAGAAAGGCACATT 13474.5
S1617 ACCUUGCACCCCACCUGCUTT AGCAGGUGGGGUGCAAGGUTT 13504.7
S1618 CCUUGCACCCCACCUGCUCTT GAGCAGGUGGGGUGCAAGGTT 13519.8
S1619 UGAUUAUGGUUUUUACACCTT GGUGUAAAAACCAUAAUCATT 13414.1
S1620 CUUUUAAAUGCACCGGCCATT UGGCCGGUGCAUUUAAAAGTT 13459.4
S1621 AUGCACCGGCCACGGUUUGTT CAAACCGUGGCCGGUGCAUTT 13504.7
S1622 UGCACCGGCCACGGUUUGUTT ACAAACCGUGGCCGGUGCATT 13504.7
S1623 AAUUAUCCACUGACCUUAUTT AUAAGGUCAGUGGAUAAUUTT 13414.1
S1624 AUUAUCCACUGACCUUAUUTT AAUAAGGUCAGUGGAUAAUTT 13414.1
S1625 UUAUCCACUGACCUUAUUATT UAAUAAGGUCAGUGGAUAATT 13414.1
S1626 GAACCAGUGUGUCAAUUUUTT AAAAUUGACACACUGGUUCTT 13429.2
S1627 CCAGUGUGUCAAUUUUAAUTT AUUAAAAUUGACACACUGGTT 13414.1
S1628 UUUUAAUGGACUCACUGGUTT ACCAGUGAGUCCAUUAAAATT 13429.2
S1629 CUCCUUCUUCAAAGAGAUUTT AAUCUCUUUGAAGAAGGAGTT 13429.2
S1630 AGAGAUUUCAACCAUUUCATT UGAAAUGGUUGAAAUCUCUTT 13414.1
S1631 GAGAUUUCAACCAUUUCAATT UUGAAAUGGUUGAAAUCUCTT 13414.1
S1632 UAUUAGACAUUUCACCUUGTT CAAGGUGAAAUGUCUAAUATT 13414.1
S1633 CAAAUGCUUCAUCUGAAGUTT ACUUCAGAUGAAGCAUUUGTT 13429.2
S1634 AUGCUUCAUCUGAAGUUGCTT GCAACUUCAGAUGAAGCAUTT 13444.3
S1635 GUUGCUGUUCUAUAUCAAGTT CUUGAUAUAGAACAGCAACTT 13429.2
S1636 CUCACACCAGCUUGGCGCATT UGCGCCAAGCUGGUGUGAGTT 13504.7
S1637 ACAAUGUAUUCCAGACUCATT UGAGUCUGGAAUACAUUGUTT 13429.2
S1638 CAAUGUAUUCCAGACUCAATT UUGAGUCUGGAAUACAUUGTT 13429.2
S1639 AAUCUAUUGUGGCUUAUACTT GUAUAAGCCACAAUAGAUUTT 13414.1
S1640 AUCUAUUGUGGCUUAUACUTT AGUAUAAGCCACAAUAGAUTT 13414.1
S1641 UCUAUUGUGGCUUAUACUATT UAGUAUAAGCCACAAUAGATT 13414.1
S1642 UUGCUUACUCUAAUAACACTT GUGUUAUUAGAGUAAGCAATT 13414.1
S1643 UAACACCAUUGCUAUACCUTT AGGUAUAGCAAUGGUGUUATT 13429.2
S1644 UUAGCAUUACUACAGAAGUTT ACUUCUGUAGUAAUGCUAATT 13414.1
S1645 AACCUCCGUAGAUUGUAAUTT AUUACAAUCUACGGAGGUUTT 13429.2
S1646 ACCUCCGUAGAUUGUAAUATT UAUUACAAUCUACGGAGGUTT 13429.2
S1647 CCUCCGUAGAUUGUAAUAUTT AUAUUACAAUCUACGGAGGTT 13429.2
S1648 UUUGCUUCUCCAAUAUGGUTT ACCAUAUUGGAGAAGCAAATT 13429.2
S1649 UAUGGUAGCUUUUGCACACTT GUGUGCAAAAGCUACCAUATT 13444.3
S1650 AUCGUGCACUCUCAGGUAUTT AUACCUGAGAGUGCACGAUTT 13459.4
S1651 ACAAAUGUACAAAACCCCATT UGGGGUUUUGUACAUUUGUTT 13429.2
S1652 CAAAUGUACAAAACCCCAATT UUGGGGUUUUGUACAUUUGTT 13429.2
S1653 AUGUACAAAACCCCAACUUTT AAGUUGGGGUUUUGUACAUTT 13429.2
S1654 UGUACAAAACCCCAACUUUTT AAAGUUGGGGUUUUGUACATT 13429.2
S1655 AACCCCAACUUUGAAAUAUTT AUAUUUCAAAGUUGGGGUUTT 13414.1
S1656 ACCCCAACUUUGAAAUAUUTT AAUAUUUCAAAGUUGGGGUTT 13414.1
S1657 CCCCAACUUUGAAAUAUUUTT AAAUAUUUCAAAGUUGGGGTT 13414.1
S1658 CUUUGAAAUAUUUUGGUGGTT CCACCAAAAUAUUUCAAAGTT 13414.1
S1659 AUAUUACCUGACCCUCUAATT UUAGAGGGUCAGGUAAUAUTT 13429.2
S1660 UAUUACCUGACCCUCUAAATT UUUAGAGGGUCAGGUAAUATT 13429.2
S1661 AGCCAACUAAGAGGUCUUUTT AAAGACCUCUUAGUUGGCUTT 13444.3
S1662 GCCAACUAAGAGGUCUUUUTT AAAAGACCUCUUAGUUGGCTT 13444.3
S1663 CUAAGAGGUCUUUUAUUGATT UCAAUAAAAGACCUCUUAGTT 13414.1
S1664 GAGGUCUUUUAUUGAGGACTT GUCCUCAAUAAAAGACCUCTT 13444.3
S1665 UGCCUAGGUGAUAUUAAUGTT CAUUAAUAUCACCUAGGCATT 13429.2
S1666 UGCUAGAGAUCUCAUUUGUTT ACAAAUGAGAUCUCUAGCATT 13429.2
S1667 AUACCUUUUGCUAUGCAAATT UUUGCAUAGCAAAAGGUAUTT 13414.1
S1668 UACCUUUUGCUAUGCAAAUTT AUUUGCAUAGCAAAAGGUATT 13414.1
S1669 AUGGCAUAUAGGUUCAAUGTT CAUUGAACCUAUAUGCCAUTT 13429.2
S1670 UGGCAUUGGAGUUACCCAATT UUGGGUAACUCCAAUGCCATT 13459.4
S1671 AAUGUUCUCUAUGAGAACCTT GGUUCUCAUAGAGAACAUUTT 13429.2
S1672 AUGUUCUCUAUGAGAACCATT UGGUUCUCAUAGAGAACAUTT 13429.2
S1673 UGUUCUCUAUGAGAACCAATT UUGGUUCUCAUAGAGAACATT 13429.2
S1674 CCAAAAACAAAUCGCCAACTT GUUGGCGAUUUGUUUUUGGTT 13444.3
S1675 AAACAAAUCGCCAACCAAUTT AUUGGUUGGCGAUUUGUUUTT 13429.2
S1676 AACAAAUCGCCAACCAAUUTT AAUUGGUUGGCGAUUUGUUTT 13429.2
S1677 ACAAAUCGCCAACCAAUUUTT AAAUUGGUUGGCGAUUUGUTT 13429.2
S1678 CAAAUCGCCAACCAAUUUATT UAAAUUGGUUGGCGAUUUGTT 13429.2
S1679 AUCGCCAACCAAUUUAACATT UGUUAAAUUGGUUGGCGAUTT 13429.2
S1680 UCGCCAACCAAUUUAACAATT UUGUUAAAUUGGUUGGCGATT 13429.2
S1681 CCAAUUUAACAAGGCGAUUTT AAUCGCCUUGUUAAAUUGGTT 13429.2
S1682 UUUAACAAGGCGAUUAGUCTT GACUAAUCGCCUUGUUAAATT 13429.2
S1683 CAAGGCGAUUAGUCAAAUUTT AAUUUGACUAAUCGCCUUGTT 13429.2
S1684 GGCGAUUAGUCAAAUUCAATT UUGAAUUUGACUAAUCGCCTT 13429.2
S1685 UUCAAGAAUCACUUACAACTT GUUGUAAGUGAUUCUUGAATT 13414.1
S1686 GAAUCACUUACAACAACAUTT AUGUUGUUGUAAGUGAUUCTT 13414.1
S1687 UCACUUACAACAACAUCAATT UUGAUGUUGUUGUAAGUGATT 13414.1
S1688 CAACAUCAACUGCAUUGGGTT CCCAAUGCAGUUGAUGUUGTT 13459.4
S1689 CAUCAACUGCAUUGGGCAATT UUGCCCAAUGCAGUUGAUGTT 13459.4
S1690 CUGCAUUGGGCAAGCUGCATT UGCAGCUUGCCCAAUGCAGTT 13489.6
S1691 UGCUCAAGCAUUAAACACATT UGUGUUUAAUGCUUGAGCATT 13429.2
S1692 GCAUUAAACACACUUGUUATT UAACAAGUGUGUUUAAUGCTT 13414.1
S1693 ACACACUUGUUAAACAACUTT AGUUGUUUAACAAGUGUGUTT 13414.1
S1694 CACACUUGUUAAACAACUUTT AAGUUGUUUAACAAGUGUGTT 13414.1
S1695 CAACUUAGCUCUAAUUUUGTT CAAAAUUAGAGCUAAGUUGTT 13414.1
S1696 CUUAGCUCUAAUUUUGGUGTT CACCAAAAUUAGAGCUAAGTT 13429.2
S1697 UUUUGGUGCAAUUUCAAGUTT ACUUGAAAUUGCACCAAAATT 13414.1
S1698 UUUCAAGUGUGCUAAAUGATT UCAUUUAGCACACUUGAAATT 13414.1
S1699 GUGUGCUAAAUGAUAUCCUTT AGGAUAUCAUUUAGCACACTT 13429.2
S1700 AUGAUAUCCUUUCGCGACUTT AGUCGCGAAAGGAUAUCAUTT 13444.3
S1701 AGUCGAGGCGGAGGUACAATT UUGUACCUCCGCCUCGACUTT 13489.6
S1702 AUUGACAGGUUAAUUACAGTT CUGUAAUUAACCUGUCAAUTT 13414.1
S1703 UUGACAGGUUAAUUACAGGTT CCUGUAAUUAACCUGUCAATT 13429.2
S1704 AGCCUUCAAACCUAUGUAATT UUACAUAGGUUUGAAGGCUTT 13429.2
S1705 ACCUAUGUAACACAACAACTT GUUGUUGUGUUACAUAGGUTT 13429.2
S1706 CCUAUGUAACACAACAACUTT AGUUGUUGUGUUACAUAGGTT 13429.2
S1707 CACAACAACUAAUCAGGGCTT GCCCUGAUUAGUUGUUGUGTT 13459.4
S1708 CAACUAAUCAGGGCUGCUGTT CAGCAGCCCUGAUUAGUUGTT 13474.5
S1709 CUAAUCAGGGCUGCUGAAATT UUUCAGCAGCCCUGAUUAGTT 13459.4
S1710 UCAGGGCUGCUGAAAUCAGTT CUGAUUUCAGCAGCCCUGATT 13474.5
S1711 AUCAGGGCUUCUGCUAAUCTT GAUUAGCAGAAGCCCUGAUTT 13459.4
S1712 UCAGGGCUUCUGCUAAUCUTT AGAUUAGCAGAAGCCCUGATT 13459.4
S1713 UCUUGCUGCUACUAAAAUGTT CAUUUUAGUAGCAGCAAGATT 13429.2
S1714 AAAGAGUUGACUUUUGUGGTT CCACAAAAGUCAACUCUUUTT 13429.2
S1715 AAGAGUUGACUUUUGUGGATT UCCACAAAAGUCAACUCUUTT 13429.2
S1716 AGAGUUGACUUUUGUGGAATT UUCCACAAAAGUCAACUCUTT 13429.2
S1717 GAGUUGACUUUUGUGGAAATT UUUCCACAAAAGUCAACUCTT 13429.2
S1718 AGGGCUACCACCUUAUGUCTT GACAUAAGGUGGUAGCCCUTT 13474.5
S1719 GGGCUACCACCUUAUGUCCTT GGACAUAAGGUGGUAGCCCTT 13489.6
S1720 GCAGCCCCGCAUGGUGUUGTT CAACACCAUGCGGGGCUGCTT 13519.8
S1721 CUUCACCACAGCGCCAGCATT UGCUGGCGCUGUGGUGAAGTT 13504.7
S1722 GGCAAAGCAUACUUCCCUCTT GAGGGAAGUAUGCUUUGCCTT 13474.5
S1723 AGCAUACUUCCCUCGUGAATT UUCACGAGGGAAGUAUGCUTT 13459.4
S1724 GCAUACUUCCCUCGUGAAGTT CUUCACGAGGGAAGUAUGCTT 13474.5
S1725 GGUGUUUUUGUGUUUAAUGTT CAUUAAACACAAAAACACCTT 13414.1
S1726 UGGCACUUCUUGGUUUAUUTT AAUAAACCAAGAAGUGCCATT 13429.2
S1727 CUUCUUUUCUCCACAAAUATT UAUUUGUGGAGAAAAGAAGTT 13414.1
S1728 UACAUUUGUCUCAGGAAAUTT AUUUCCUGAGACAAAUGUATT 13414.1
S1729 AUUGUGAUGUCGUUAUUGGTT CCAAUAACGACAUCACAAUTT 13429.2
S1730 CAACACAGUUUAUGAUCCUTT AGGAUCAUAAACUGUGUUGTT 13429.2
S1731 AGAAGAGCUGGACAAGUACTT GUACUUGUCCAGCUCUUCUTT 13459.4
S1732 AAAUCAUACAUCACCAGAUTT AUCUGGUGAUGUAUGAUUUTT 13414.1
S1733 AAUCAUACAUCACCAGAUGTT CAUCUGGUGAUGUAUGAUUTT 13429.2
S1734 AUCAUACAUCACCAGAUGUTT ACAUCUGGUGAUGUAUGAUTT 13429.2
S1735 UCAUACAUCACCAGAUGUUTT AACAUCUGGUGAUGUAUGATT 13429.2
S1736 AAAGAAAUUGACCGCCUCATT UGAGGCGGUCAAUUUCUUUTT 13444.3
S1737 AAGAAAUUGACCGCCUCAATT UUGAGGCGGUCAAUUUCUUTT 13444.3
S1738 AUUGACCGCCUCAAUGAGGTT CCUCAUUGAGGCGGUCAAUTT 13474.5
S1739 UGAGGUCGCUAAAAAUUUATT UAAAUUUUUAGCGACCUCATT 13414.1
S1740 AUGAAUCACUCAUUGACCUTT AGGUCAAUGAGUGAUUCAUTT 13429.2
S1741 UGAAUCACUCAUUGACCUUTT AAGGUCAAUGAGUGAUUCATT 13429.2
S1742 GAAUUGGGAAAAUAUGAGCTT GCUCAUAUUUUCCCAAUUCTT 13429.2
S1743 UUGGGAAAAUAUGAGCAAUTT AUUGCUCAUAUUUUCCCAATT 13414.1
S1744 UAUAUUAAAUGGCCUUGGUTT ACCAAGGCCAUUUAAUAUATT 13414.1
S1745 AUGGCCUUGGUAUGUUUGGTT CCAAACAUACCAAGGCCAUTT 13459.4
S1746 GGGUGCAUGCUCUUGUGGUTT ACCACAAGAGCAUGCACCCTT 13489.6
S1747 GGGUGUCAAAUUACAUUACTT GUAAUGUAAUUUGACACCCTT 13429.2
上表中的SiRNA的目标基因为刺蛋白。
表5、针对第三编码区的SiRNA分子
SiRNA序号 正义链序列 反义链序列 MW
S1748 UUACUGCACAGCCAGUAAATT UUUACUGGCUGUGCAGUAATT 13444.3
S1749 AAAUUGACAAUGCUUCUCCTT GGAGAAGCAUUGUCAAUUUTT 13429.2
S1750 UGCUUCUCCUGCAAGUACUTT AGUACUUGCAGGAGAAGCATT 13459.4
S1751 GUACUGUUCAUGCUACAGCTT GCUGUAGCAUGAACAGUACTT 13459.4
S1752 CGAUACCGCUACAAGCCUCTT GAGGCUUGUAGCGGUAUCGTT 13489.6
S1753 GCCUCACUCCCUUUCGGAUTT AUCCGAAAGGGAGUGAGGCTT 13489.6
S1754 UAAUUGCGCUCAAUAAAAGTT CUUUUAUUGAGCGCAAUUATT 13414.1
S1755 UUGCGCUCAAUAAAAGAUGTT CAUCUUUUAUUGAGCGCAATT 13429.2
S1756 UAAAAGAUGGCAGCUAGCCTT GGCUAGCUGCCAUCUUUUATT 13459.4
S1757 AAGAUGGCAGCUAGCCCUUTT AAGGGCUAGCUGCCAUCUUTT 13474.5
S1758 AGAUGGCAGCUAGCCCUUUTT AAAGGGCUAGCUGCCAUCUTT 13474.5
S1759 GAUGGCAGCUAGCCCUUUATT UAAAGGGCUAGCUGCCAUCTT 13474.5
S1760 GGGCUUCCAGUUCAUUUGCTT GCAAAUGAACUGGAAGCCCTT 13474.5
S1761 UUUACUGCUGCUAUUUGUUTT AACAAAUAGCAGCAGUAAATT 13414.1
S1762 UUUUUGUACCUCUAUGCCUTT AGGCAUAGAGGUACAAAAATT 13429.2
S1763 UGCAUCAACGCAUGUAGAATT UUCUACAUGCGUUGAUGCATT 13444.3
S1764 CGCAUGUAGAAUUAUUAUGTT CAUAAUAAUUCUACAUGCGTT 13414.1
S1765 UUAUUAUGAGAUGUUGGCUTT AGCCAACAUCUCAUAAUAATT 13414.1
S1766 GUGCAAAUCCAAGAACCCATT UGGGUUCUUGGAUUUGCACTT 13459.4
S1767 AUCCAAGAACCCAUUACUUTT AAGUAAUGGGUUCUUGGAUTT 13429.2
S1768 UCCAAGAACCCAUUACUUUTT AAAGUAAUGGGUUCUUGGATT 13429.2
S1769 GAACCCAUUACUUUAUGAUTT AUCAUAAAGUAAUGGGUUCTT 13414.1
S1770 CCCAUUACUUUAUGAUGCCTT GGCAUCAUAAAGUAAUGGGTT 13444.3
S1771 CUACUUUGUUUGCUGGCACTT GUGCCAGCAAACAAAGUAGTT 13459.4
S1772 CUAUGACUACUGUAUACCATT UGGUAUACAGUAGUCAUAGTT 13429.2
S1773 CAGUGUCACAGAUACAAUUTT AAUUGUAUCUGUGACACUGTT 13429.2
S1774 UUGUCGUUACUGAAGGUGATT UCACCUUCAGUAACGACAATT 13444.3
S1775 GGUGACGGCAUUUCAACACTT GUGUUGAAAUGCCGUCACCTT 13474.5
S1776 CACCAAAACUCAAAGAAGATT UCUUCUUUGAGUUUUGGUGTT 13429.2
S1777 AACUCAAAGAAGACUACCATT UGGUAGUCUUCUUUGAGUUTT 13429.2
S1778 ACUCAAAGAAGACUACCAATT UUGGUAGUCUUCUUUGAGUTT 13429.2
S1779 CUCAAAGAAGACUACCAAATT UUUGGUAGUCUUCUUUGAGTT 13429.2
S1780 AGAAGACUACCAAAUUGGUTT ACCAAUUUGGUAGUCUUCUTT 13429.2
S1781 GAAGACUACCAAAUUGGUGTT CACCAAUUUGGUAGUCUUCTT 13444.3
S1782 GACUACCAAAUUGGUGGUUTT AACCACCAAUUUGGUAGUCTT 13444.3
S1783 AUUGGUGGUUAUUCUGAGGTT CCUCAGAAUAACCACCAAUTT 13444.3
S1784 UUGGUGGUUAUUCUGAGGATT UCCUCAGAAUAACCACCAATT 13444.3
S1785 AGACUAUGUCGUUGUACAUTT AUGUACAACGACAUAGUCUTT 13429.2
S1786 GACUAUGUCGUUGUACAUGTT CAUGUACAACGACAUAGUCTT 13444.3
S1787 GUUUACUACCAGCUUGAGUTT ACUCAAGCUGGUAGUAAACTT 13444.3
S1788 AUUACUACAGACACUGGUATT UACCAGUGUCUGUAGUAAUTT 13429.2
S1789 UUACUACAGACACUGGUAUTT AUACCAGUGUCUGUAGUAATT 13429.2
S1790 AAUGCUACAUUCUUCAUCUTT AGAUGAAGAAUGUAGCAUUTT 13414.1
S1791 AUGCUACAUUCUUCAUCUUTT AAGAUGAAGAAUGUAGCAUTT 13414.1
S1792 UGCUACAUUCUUCAUCUUUTT AAAGAUGAAGAAUGUAGCATT 13414.1
S1793 CAAGCUUGUUAAAGACCCATT UGGGUCUUUAACAAGCUUGTT 13444.3
S1794 GCUUGUUAAAGACCCACCGTT CGGUGGGUCUUUAACAAGCTT 13474.5
S1795 AGACCCACCGAAUGUGCAATT UUGCACAUUCGGUGGGUCUTT 13474.5
S1796 GACCCACCGAAUGUGCAAATT UUUGCACAUUCGGUGGGUCTT 13474.5
S1797 UGUGCAAAUACACACAAUCTT GAUUGUGUGUAUUUGCACATT 13429.2
S1798 AUACACACAAUCGACGGCUTT AGCCGUCGAUUGUGUGUAUTT 13459.4
S1799 UACACACAAUCGACGGCUCTT GAGCCGUCGAUUGUGUGUATT 13474.5
S1800 UCGACGGCUCUUCAGGAGUTT ACUCCUGAAGAGCCGUCGATT 13489.6
S1801 UCCAGCAAUGGAUCCAAUUTT AAUUGGAUCCAUUGCUGGATT 13444.3
S1802 UGGAUCCAAUUUAUGAUGATT UCAUCAUAAAUUGGAUCCATT 13414.1
S1803 UUUAUGAUGAGCCGACGACTT GUCGUCGGCUCAUCAUAAATT 13459.4
S1804 GCACAAGAAAGUGAGUACGTT CGUACUCACUUUCUUGUGCTT 13459.4
S1805 GAAAGUGAGUACGAACUUATT UAAGUUCGUACUCACUUUCTT 13429.2
S1806 AGUGAGUACGAACUUAUGUTT ACAUAAGUUCGUACUCACUTT 13429.2
S1807 GUGAGUACGAACUUAUGUATT UACAUAAGUUCGUACUCACTT 13429.2
S1808 CUUAUGUACUCAUUCGUUUTT AAACGAAUGAGUACAUAAGTT 13414.1
S1809 GAAACAGGUACGUUAAUAGTT CUAUUAACGUACCUGUUUCTT 13429.2
S1810 ACAGGUACGUUAAUAGUUATT UAACUAUUAACGUACCUGUTT 13414.1
S1811 CAGGUACGUUAAUAGUUAATT UUAACUAUUAACGUACCUGTT 13414.1
S1812 UAGUUAAUAGCGUACUUCUTT AGAAGUACGCUAUUAACUATT 13414.1
S1813 UAGCGUACUUCUUUUUCUUTT AAGAAAAAGAAGUACGCUATT 13414.1
S1814 CGUGAGUUUAGUAAAACCATT UGGUUUUACUAAACUCACGTT 13429.2
S1815 AACCAACGGUUUACGUCUATT UAGACGUAAACCGUUGGUUTT 13444.3
S1816 ACCAACGGUUUACGUCUACTT GUAGACGUAAACCGUUGGUTT 13459.4
S1817 CCAACGGUUUACGUCUACUTT AGUAGACGUAAACCGUUGGTT 13459.4
S1818 CGGUUUACGUCUACUCGCGTT CGCGAGUAGACGUAAACCGTT 13489.6
S1819 AAAUCUGAACUCUUCUGAATT UUCAGAAGAGUUCAGAUUUTT 13414.1
S1820 AAUCUGAACUCUUCUGAAGTT CUUCAGAAGAGUUCAGAUUTT 13429.2
S1821 AUCUGAACUCUUCUGAAGGTT CCUUCAGAAGAGUUCAGAUTT 13444.3
S1822 UCUGAACUCUUCUGAAGGATT UCCUUCAGAAGAGUUCAGATT 13444.3
S1823 CUCUUCUGAAGGAGUUCCUTT AGGAACUCCUUCAGAAGAGTT 13459.4
S1824 GGAGUUCCUGAUCUUCUGGTT CCAGAAGAUCAGGAACUCCTT 13474.5
上表中S1748-S1770SiRNA的目标基因是UP1,S1771-S1803SiRNA的目标基因是UP1和UP2,S1804-S1808SiRNA的目标基因是UP2,S1809-S1811SiRNA的目标基因是UP2和E,S1812-S1824SiRNA的目标基因是E。
表6、针对第四编码区的SiRNA分子
SiRNA序号 正义链序列 反义链序列 MW
S1825 CGGUACUAUUACCGUUGAGTT CUCAACGGUAAUAGUACCGTT 13459.4
S1826 ACAACUCCUGGAACAAUGGTT CCAUUGUUCCAGGAGUUGUTT 13459.4
S1827 CAACUCCUGGAACAAUGGATT UCCAUUGUUCCAGGAGUUGTT 13459.4
S1828 CUCCUGGAACAAUGGAACCTT GGUUCCAUUGUUCCAGGAGTT 13474.5
S1829 CAAUGGAACCUAGUAAUAGTT CUAUUACUAGGUUCCAUUGTT 13429.2
S1830 UGGAACCUAGUAAUAGGUUTT AACCUAUUACUAGGUUCCATT 13429.2
S1831 CCUAGUAAUAGGUUUCCUATT UAGGAAACCUAUUACUAGGTT 13429.2
S1832 UAGGUUUCCUAUUCCUAGCTT GCUAGGAAUAGGAAACCUATT 13444.3
S1833 UUUGCCUAUUCUAAUCGGATT UCCGAUUAGAAUAGGCAAATT 13429.2
S1834 UCGGAACAGGUUUUUGUACTT GUACAAAAACCUGUUCCGATT 13444.3
S1835 UAAAGCUUGUUUUCCUCUGTT CAGAGGAAAACAAGCUUUATT 13429.2
S1836 AGCUUGUUUUCCUCUGGCUTT AGCCAGAGGAAAACAAGCUTT 13459.4
S1837 GCUUGUUUUCCUCUGGCUCTT GAGCCAGAGGAAAACAAGCTT 13474.5
S1838 CACUUGCUUGUUUUGUGCUTT AGCACAAAACAAGCAAGUGTT 13444.3
S1839 UUAAUUGGGUGACUGGCGGTT CCGCCAGUCACCCAAUUAATT 13474.5
S1840 UUGGGUGACUGGCGGGAUUTT AAUCCCGCCAGUCACCCAATT 13489.6
S1841 UGGCUUGUAUUGUAGGCUUTT AAGCCUACAAUACAAGCCATT 13444.3
S1842 UGUGGUCAUUCAACCCAGATT UCUGGGUUGAAUGACCACATT 13459.4
S1843 CCCAGAAACAAACAUUCUUTT AAGAAUGUUUGUUUCUGGGTT 13429.2
S1844 ACAAACAUUCUUCUCAAUGTT CAUUGAGAAGAAUGUUUGUTT 13414.1
S1845 CAAACAUUCUUCUCAAUGUTT ACAUUGAGAAGAAUGUUUGTT 13414.1
S1846 ACAUUCUUCUCAAUGUGCCTT GGCACAUUGAGAAGAAUGUTT 13444.3
S1847 CAUUCUUCUCAAUGUGCCUTT AGGCACAUUGAGAAGAAUGTT 13444.3
S1848 UGUGCCUCUCCGGGGGACATT UGUCCCCCGGAGAGGCACATT 13519.8
S1849 UUGUGACCAGACCGCUCAUTT AUGAGCGGUCUGGUCACAATT 13474.5
S1850 AGUGAACUUGUCAUUGGUGTT CACCAAUGACAAGUUCACUTT 13444.3
S1851 GUGAACUUGUCAUUGGUGCTT GCACCAAUGACAAGUUCACTT 13459.4
S1852 CUUGUCAUUGGUGCUGUGATT UCACAGCACCAAUGACAAGTT 13459.4
S1853 GGACCUGCCAAAAGAGAUCTT GAUCUCUUUUGGCAGGUCCTT 13474.5
S1854 AAGAGAUCACUGUGGCUACTT GUAGCCACAGUGAUCUCUUTT 13459.4
S1855 AGAGAUCACUGUGGCUACATT UGUAGCCACAGUGAUCUCUTT 13459.4
S1856 GAGAUCACUGUGGCUACAUTT AUGUAGCCACAGUGAUCUCTT 13459.4
S1857 AUUAGGAGCGUCGCAGCGUTT ACGCUGCGACGCUCCUAAUTT 13489.6
S1858 UUAGGAGCGUCGCAGCGUGTT CACGCUGCGACGCUCCUAATT 13504.7
S1859 CCGCUACCGUAUUGGAAACTT GUUUCCAAUACGGUAGCGGTT 13474.5
S1860 AUUAAAUACAGACCACGCCTT GGCGUGGUCUGUAUUUAAUTT 13444.3
S1861 UUAAAUACAGACCACGCCGTT CGGCGUGGUCUGUAUUUAATT 13459.4
S1862 AUACAGACCACGCCGGUAGTT CUACCGGCGUGGUCUGUAUTT 13489.6
S1863 UACAGACCACGCCGGUAGCTT GCUACCGGCGUGGUCUGUATT 13504.7
S1864 CGACAAUAUUGCUUUGCUATT UAGCAAAGCAAUAUUGUCGTT 13429.2
S1865 UAUUGCUUUGCUAGUACAGTT CUGUACUAGCAAAGCAAUATT 13429.2
上表中的SiRNA的目标基因为M。
表7、针对第五编码区的SiRNA分子
SiRNA序号 正义链序列 反义链序列 MW
S1866 UAAGUUCAAUAGUGAGACATT UGUCUCACUAUUGAACUUATT 13414.1
S1867 GUUCAAUAGUGAGACAAUUTT AAUUGUCUCACUAUUGAACTT 13414.1
S1868 GCCUCUAACUAAGAAGAAUTT AUUCUUCUUAGUUAGAGGCTT 13429.2
S1869 CUAAGAAGAAUUAUUCGGATT UCCGAAUAAUUCUUCUUAGTT 13414.1
S1870 GAAGAAUUAUUCGGAGUUATT UAACUCCGAAUAAUUCUUCTT 13414.1
S1871 GAAUUAUUCGGAGUUAGAUTT AUCUAACUCCGAAUAAUUCTT 13414.1
S1872 UUAUUCGGAGUUAGAUGAUTT AUCAUCUAACUCCGAAUAATT 13414.1
S1873 GAACCUAUGGAGUUAGAUUTT AAUCUAACUCCAUAGGUUCTT 13429.2
S1874 CCUAUGGAGUUAGAUUAUCTT GAUAAUCUAACUCCAUAGGTT 13429.2
上表中的SiRNA的目标基因为UP3。
表8、针对第六编码区的SiRNA分子
SiRNA序号 正义链序列 反义链序列 MW
S1875 AAUUAUUCUCUUCCUGACATT UGUCAGGAAGAGAAUAAUUTT 13414.1
S1876 AUUAUUCUCUUCCUGACAUTT AUGUCAGGAAGAGAAUAAUTT 13414.1
S1877 UUAUUCUCUUCCUGACAUUTT AAUGUCAGGAAGAGAAUAATT 13414.1
S1878 AAGAACCUUGCCCAUCAGGTT CCUGAUGGGCAAGGUUCUUTT 13474.5
S1879 AGAACCUUGCCCAUCAGGATT UCCUGAUGGGCAAGGUUCUTT 13474.5
S1880 GAACCUUGCCCAUCAGGAATT UUCCUGAUGGGCAAGGUUCTT 13474.5
S1881 CCUUGCCCAUCAGGAACAUTT AUGUUCCUGAUGGGCAAGGTT 13474.5
S1882 CAUACGAGGGCAAUUCACCTT GGUGAAUUGCCCUCGUAUGTT 13474.5
S1883 UUCACCAUUUCACCCUCUUTT AAGAGGGUGAAAUGGUGAATT 13444.3
S1884 UAAAUUUGCACUAACUUGCTT GCAAGUUAGUGCAAAUUUATT 13414.1
S1885 AUUUGCACUAACUUGCACUTT AGUGCAAGUUAGUGCAAAUTT 13429.2
S1886 UUUGCACUAACUUGCACUATT UAGUGCAAGUUAGUGCAAATT 13429.2
S1887 CUUGCACUAGCACACACUUTT AAGUGUGUGCUAGUGCAAGTT 13459.4
S1888 GAUCAGUUUCACCAAAACUTT AGUUUUGGUGAAACUGAUCTT 13429.2
S1889 AACUUUUCAUCAGACAAGATT UCUUGUCUGAUGAAAAGUUTT 13414.1
S1890 ACUUUUCAUCAGACAAGAGTT CUCUUGUCUGAUGAAAAGUTT 13429.2
S1891 CUUUUCAUCAGACAAGAGGTT CCUCUUGUCUGAUGAAAAGTT 13444.3
S1892 GAGGAGGUUCAACAAGAGCTT GCUCUUGUUGAACCUCCUCTT 13474.5
S1893 CAAGAGCUCUACUCGCCACTT GUGGCGAGUAGAGCUCUUGTT 13489.6
S1894 GAGCUCUACUCGCCACUUUTT AAAGUGGCGAGUAGAGCUCTT 13474.5
S1895 UACUUUGCUUCACCAUUAATT UUAAUGGUGAAGCAAAGUATT 13414.1上表中的SiRNA的目标基因为UP4。
表9、针对第七编码区的SiRNA分子
SiRNA序号 正义链序列 反义链序列 MW
S1896 UGGACCCCAAUCAAACCAATT UUGGUUUGAUUGGGGUCCATT 13459.4
S1897 UCAAACCAACGUAGUGCCCTT GGGCACUACGUUGGUUUGATT 13474.5
S1898 ACCAACGUAGUGCCCCCCGTT CGGGGGGCACUACGUUGGUTT 13519.8
S1899 CGUAGUGCCCCCCGCAUUATT UAAUGCGGGGGGCACUACGTT 13504.7
S1900 CUGACAAUAACCAGAAUGGTT CCAUUCUGGUUAUUGUCAGTT 13444.3
S1901 UAACCAGAAUGGAGGACGCTT CCGUCCUCCAUUCUGGUUATT 13474.5
S1902 UGGAGGACGCAAUGGGGCATT UGCCCCAUUGCGUCCUCCATT 13504.7
S1903 UGGGGCAAGGCCAAAACAGTT CUGUUUUGGCCUUGCCCCATT 13489.6
S1904 GGCCAAAACAGCGCCGACCTT GGUCGGCGCUGUUUUGGCCTT 13519.8
S1905 AACAGCGCCGACCCCAAGGTT CCUUGGGGUCGGCGCUGUUTT 13519.8
S1906 ACAGCGCCGACCCCAAGGUTT ACCUUGGGGUCGGCGCUGUTT 13519.8
S1907 CAGCGCCGACCCCAAGGUUTT AACCUUGGGGUCGGCGCUGTT 13519.8
S1908 GGUUUACCCAAUAAUACUGTT CAGUAUUAUUGGGUAAACCTT 13429.2
S1909 UAAUACUGCGUCUUGGUUCTT GAACCAAGACGCAGUAUUATT 13444.3
S1910 UACUGCGUCUUGGUUCACATT UGUGAACCAAGACGCAGUATT 13459.4
S1911 GGAGGAACUUAGAUUCCCUTT AGGGAAUCUAAGUUCCUCCTT 13459.4
S1912 CUUAGAUUCCCUCGAGGCCTT GGCCUCGAGGGAAUCUAAGTT 13489.6
S1913 UCAACACCAAUAGUGGUCCTT GGACCACUAUUGGUGUUGATT 13459.4
S1914 CACCAAUAGUGGUCCAGAUTT AUCUGGACCACUAUUGGUGTT 13459.4
S1915 UAGUGGUCCAGAUGACCAATT UUGGUCAUCUGGACCACUATT 13459.4
S1916 AUUGGCUACUACCGAAGAGTT CUCUUCGGUAGUAGCCAAUTT 13459.4
S1917 UUGGCUACUACCGAAGAGCTT GCUCUUCGGUAGUAGCCAATT 13474.5
S1918 GAGCUACCCGACGAGUUCGTT CGAACUCGUCGGGUAGCUCTT 13504.7
S1919 AAUGAAAGAGCUCAGCCCCTT GGGGCUGAGCUCUUUCAUUTT 13474.5
S1920 AUGAAAGAGCUCAGCCCCATT UGGGGCUGAGCUCUUUCAUTT 13474.5
S1921 UGAAAGAGCUCAGCCCCAGTT CUGGGGCUGAGCUCUUUCATT 13489.6
S1922 AGAGCUCAGCCCCAGAUGGTT CCAUCUGGGGCUGAGCUCUTT 13504.7
S1923 GAGCUCAGCCCCAGAUGGUTT ACCAUCUGGGGCUGAGCUCTT 13504.7
S1924 CUGGCCCAGAAGCUUCACUTT AGUGAAGCUUCUGGGCCAGTT 13489.6
S1925 GCUUCACUUCCCUACGGCGTT CGCCGUAGGGAAGUGAAGCTT 13504.7
S1926 CAAAGAAGGCAUCGUAUGGTT CCAUACGAUGCCUUCUUUGTT 13459.4
S1927 AGAAGGCAUCGUAUGGGUUTT AACCCAUACGAUGCCUUCUTT 13459.4
S1928 GAAGGCAUCGUAUGGGUUGTT CAACCCAUACGAUGCCUUCTT 13474.5
S1929 GGCAUCGUAUGGGUUGCAATT UUGCAACCCAUACGAUGCCTT 13474.5
S1930 CUGAGGGAGCCUUGAAUACTT GUAUUCAAGGCUCCCUCAGTT 13474.5
S1931 UACACCCAAAGACCACAUUTT AAUGUGGUCUUUGGGUGUATT 13444.3
S1932 AGACCACAUUGGCACCCGCTT GCGGGUGCCAAUGUGGUCUTT 13504.7
S1933 GACCACAUUGGCACCCGCATT UGCGGGUGCCAAUGUGGUCTT 13504.7
S1934 UCCUAAUAACAAUGCUGCCTT GGCAGCAUUGUUAUUAGGATT 13444.3
S1935 UAACAAUGCUGCCACCGUGTT CACGGUGGCAGCAUUGUUATT 13474.5
S1936 CAAUGCUGCCACCGUGCUATT UAGCACGGUGGCAGCAUUGTT 13489.6
S1937 UGCUGCCACCGUGCUACAATT UUGUAGCACGGUGGCAGCATT 13489.6
S1938 CUUCCUCAAGGAACAACAUTT AUGUUGUUCCUUGAGGAAGTT 13444.3
S1939 GGAACAACAUUGCCAAAAGTT CUUUUGGCAAUGUUGUUCCTT 13444.3
S1940 CAACAUUGCCAAAAGGCUUTT AAGCCUUUUGGCAAUGUUGTT 13444.3
S1941 CAUUGCCAAAAGGCUUCUATT UAGAAGCCUUUUGGCAAUGTT 13444.3
S1942 AAGGCUUCUACGCAGAGGGTT CCCUCUGCGUAGAAGCCUUTT 13489.6
S1943 GGCUUCUACGCAGAGGGAATT UUCCCUCUGCGUAGAAGCCTT 13489.6
S1944 GCAGAGGCGGCAGUCAAGCTT GCUUGACUGCCGCCUCUGCTT 13519.8
S1945 GCCUCUUCUCGCUCCUCAUTT AUGAGGAGCGAGAAGAGGCTT 13489.6
S1946 UUCAAGAAAUUCAACUCCUTT AGGAGUUGAAUUUCUUGAATT 13414.1
S1947 GAAAUUCAACUCCUGGCAGTT CUGCCAGGAGUUGAAUUUCTT 13459.4
S1948 AUUCAACUCCUGGCAGCAGTT CUGCUGCCAGGAGUUGAAUTT 13474.5
S1949 UUCAACUCCUGGCAGCAGUTT ACUGCUGCCAGGAGUUGAATT 13474.5
S1950 CUCCUGGCAGCAGUAGGGGTT CCCCUACUGCUGCCAGGAGTT 13519.8
S1951 AUUCUCCUGCUCGAAUGGCTT GCCAUUCGAGCAGGAGAAUTT 13474.5
S1952 UUCUCCUGCUCGAAUGGCUTT AGCCAUUCGAGCAGGAGAATT 13474.5
S1953 UGGCUAGCGGAGGUGGUGATT UCACCACCUCCGCUAGCCATT 13504.7
S1954 ACUGCCCUCGCGCUAUUGCTT GCAAUAGCGCGAGGGCAGUTT 13504.7
S1955 CUGCCCUCGCGCUAUUGCUTT AGCAAUAGCGCGAGGGCAGTT 13504.7
S1956 CCAGCUUGAGAGCAAAGUUTT AACUUUGCUCUCAAGCUGGTT 13459.4
S1957 AGUUUCUGGUAAAGGCCAATT UUGGCCUUUACCAGAAACUTT 13444.3
S1958 GUUUCUGGUAAAGGCCAACTT GUUGGCCUUUACCAGAAACTT 13459.4
S1959 AGGCCAACAACAACAAGGCTT GCCUUGUUGUUGUUGGCCUTT 13474.5
S1960 GGCCAACAACAACAAGGCCTT GGCCUUGUUGUUGUUGGCCTT 13489.6
S1961 CAACAACAAGGCCAAACUGTT CAGUUUGGCCUUGUUGUUGTT 13459.4
S1962 CAACAAGGCCAAACUGUCATT UGACAGUUUGGCCUUGUUGTT 13459.4
S1963 CAAGGCCAAACUGUCACUATT UAGUGACAGUUUGGCCUUGTT 13459.4
S1964 GGCCAAACUGUCACUAAGATT UCUUAGUGACAGUUUGGCCTT 13459.4
S1965 ACUGUCACUAAGAAAUCUGTT CAGAUUUCUUAGUGACAGUTT 13429.2
S1966 CUGUCACUAAGAAAUCUGCTT GCAGAUUUCUUAGUGACAGTT 13444.3
S1967 GAAAUCUGCUGCUGAGGCATT UGCCUCAGCAGCAGAUUUCTT 13474.5
S1968 AUCUGCUGCUGAGGCAUCUTT AGAUGCCUCAGCAGCAGAUTT 13474.5
S1969 UCUGCUGCUGAGGCAUCUATT UAGAUGCCUCAGCAGCAGATT 13474.5
S1970 AAAGCCUCGCCAAAAACGUTT ACGUUUUUGGCGAGGCUUUTT 13459.4
S1971 AAGCCUCGCCAAAAACGUATT UACGUUUUUGGCGAGGCUUTT 13459.4
S1972 AGCCUCGCCAAAAACGUACTT GUACGUUUUUGGCGAGGCUTT 13474.5
S1973 GCCUCGCCAAAAACGUACUTT AGUACGUUUUUGGCGAGGCTT 13474.5
S1974 AAACGUACUGCCACAAAACTT GUUUUGUGGCAGUACGUUUTT 13444.3
S1975 AACGUACUGCCACAAAACATT UGUUUUGUGGCAGUACGUUTT 13444.3
S1976 ACGUACUGCCACAAAACAGTT CUGUUUUGUGGCAGUACGUTT 13459.4
S1977 CGUACUGCCACAAAACAGUTT ACUGUUUUGUGGCAGUACGTT 13459.4
S1978 AACAGUACAACGUCACUCATT UGAGUGACGUUGUACUGUUTT 13444.3
S1979 ACAGUACAACGUCACUCAATT UUGAGUGACGUUGUACUGUTT 13444.3
S1980 CAGUACAACGUCACUCAAGTT CUUGAGUGACGUUGUACUGTT 13459.4
S1981 CGUCACUCAAGCAUUUGGGTT CCCAAAUGCUUGAGUGACGTT 13474.5
S1982 GCAUUUGGGAGACGUGGUCTT GACCACGUCUCCCAAAUGCTT 13489.6
S1983 CAAACCCAAGGAAAUUUCGTT CGAAAUUUCCUUGGGUUUGTT 13444.3
S1984 ACCCAAGGAAAUUUCGGGGTT CCCCGAAAUUUCCUUGGGUTT 13474.5
S1985 CCCAAGGAAAUUUCGGGGATT UCCCCGAAAUUUCCUUGGGTT 13474.5
S1986 GGAAAUUUCGGGGACCAAGTT CUUGGUCCCCGAAAUUUCCTT 13474.5
S1987 AUUUCGGGGACCAAGACCUTT AGGUCUUGGUCCCCGAAAUTT 13474.5
S1988 UUUCGGGGACCAAGACCUATT UAGGUCUUGGUCCCCGAAATT 13474.5
S1989 GACCUAAUCAGACAAGGAATT UUCCUUGUCUGAUUAGGUCTT 13444.3
S1990 UCAGACAAGGAACUGAUUATT UAAUCAGUUCCUUGUCUGATT 13429.2
S1991 GGAACUGAUUACAAACAUUTT AAUGUUUGUAAUCAGUUCCTT 13414.1
S1992 CUGAUUACAAACAUUGGCCTT GGCCAAUGUUUGUAAUCAGTT 13444.3
S1993 ACAUUGGCCGCAAAUUGCATT UGCAAUUUGCGGCCAAUGUTT 13459.4
S1994 CAUUGGCCGCAAAUUGCACTT GUGCAAUUUGCGGCCAAUGTT 13474.5
S1995 AUUGCACAAUUUGCUCCAATT UUGGAGCAAAUUGUGCAAUTT 13429.2
S1996 UUGCACAAUUUGCUCCAAGTT CUUGGAGCAAAUUGUGCAATT 13444.3
S1997 UUUGCUCCAAGUGCCUCUGTT CAGAGGCACUUGGAGCAAATT 13474.5
S1998 GUGCCUCUGCAUUCUUUGGTT CCAAAGAAUGCAGAGGCACTT 13474.5
S1999 UGUCACGCAUUGGCAUGGATT UCCAUGCCAAUGCGUGACATT 13474.5
S2000 GUCACACCUUCGGGAACAUTT AUGUUCCCGAAGGUGUGACTT 13474.5
S2001 CAUGGCUGACUUAUCAUGGTT CCAUGAUAAGUCAGCCAUGTT 13459.4
S2002 AUUGGAUGACAAAGAUCCATT UGGAUCUUUGUCAUCCAAUTT 13429.2
S2003 UUGGAUGACAAAGAUCCACTT GUGGAUCUUUGUCAUCCAATT 13444.3
S2004 AGAUCCACAAUUCAAAGACTT GUCUUUGAAUUGUGGAUCUTT 13429.2
S2005 GAUCCACAAUUCAAAGACATT UGUCUUUGAAUUGUGGAUCTT 13429.2
S2006 UUCAAAGACAACGUCAUACTT GUAUGACGUUGUCUUUGAATT 13429.2
S2007 AGACAACGUCAUACUGCUGTT CAGCAGUAUGACGUUGUCUTT 13459.4
S2008 GACAACGUCAUACUGCUGATT UCAGCAGUAUGACGUUGUCTT 13459.4
S2009 CGUCAUACUGCUGAACAAGTT CUUGUUCAGCAGUAUGACGTT 13459.4
S2010 CAAGCACAUUGACGCAUACTT GUAUGCGUCAAUGUGCUUGTT 13459.4
S2011 GCACAUUGACGCAUACAAATT UUUGUAUGCGUCAAUGUGCTT 13444.3
S2012 AACAUUCCCACCAACAGAGTT CUCUGUUGGUGGGAAUGUUTT 13459.4
S2013 ACAUUCCCACCAACAGAGCTT GCUCUGUUGGUGGGAAUGUTT 13474.5
S2014 CAUUCCCACCAACAGAGCCTT GGCUCUGUUGGUGGGAAUGTT 13489.6
S2015 CAGAGCCUAAAAAGGACAATT UUGUCCUUUUUAGGCUCUGTT 13444.3
S2016 AGGACAAAAAGAAAAAGACTT GUCUUUUUCUUUUUGUCCUTT 13414.1
S2017 GGACAAAAAGAAAAAGACUTT AGUCUUUUUCUUUUUGUCCTT 13414.1
S2018 AAGAAAAAGACUGAUGAAGTT CUUCAUCAGUCUUUUUCUUTT 13414.1
S2019 AGAAAAAGACUGAUGAAGCTT GCUUCAUCAGUCUUUUUCUTT 13429.2
S2020 GAAAAAGACUGAUGAAGCUTT AGCUUCAUCAGUCUUUUUCTT 13429.2
S2021 AAAGACUGAUGAAGCUCAGTT CUGAGCUUCAUCAGUCUUUTT 13444.3
S2022 AAGACUGAUGAAGCUCAGCTT GCUGAGCUUCAUCAGUCUUTT 13459.4
S2023 AGACUGAUGAAGCUCAGCCTT GGCUGAGCUUCAUCAGUCUTT 13474.5
S2024 GACUGAUGAAGCUCAGCCUTT AGGCUGAGCUUCAUCAGUCTT 13474.5
S2025 GCUCAGCCUUUGCCGCAGATT UCUGCGGCAAAGGCUGAGCTT 13504.7
S2026 AAGAAGCAGCCCACUGUGATT UCACAGUGGGCUGCUUCUUTT 13474.5
S2027 AGAAGCAGCCCACUGUGACTT GUCACAGUGGGCUGCUUCUTT 13489.6
S2028 GAAGCAGCCCACUGUGACUTT AGUCACAGUGGGCUGCUUCTT 13489.6
S2029 GCAGCCCACUGUGACUCUUTT AAGAGUCACAGUGGGCUGCTT 13489.6
S2030 CUUCAAAAUUCCAUGAGUGTT CACUCAUGGAAUUUUGAAGTT 13429.2
S2031 AAUUCCAUGAGUGGAGCUUTT AAGCUCCACUCAUGGAAUUTT 13444.3
S2032 AUUCCAUGAGUGGAGCUUCTT GAAGCUCCACUCAUGGAAUTT 13459.4
S2033 UUCCAUGAGUGGAGCUUCUTT AGAAGCUCCACUCAUGGAATT 13459.4
上表中S1896-S1921SiRNA的目标基因是UP5和N,S1922-S2033SiRNA的目标基因是N。
对于以上所说的同源度的数值,以80%以上为更佳。本发明所说之同源度是指任何攻击SARS病毒的SiRNA,其核苷酸序列和本发明所说的核苷酸序列(I)的正义链或负义链相应位置上的核苷酸中的15个以上(即大于70%)或17个以上(即大于80%)相同。
本发明所提供的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)还包括针对以上所提到的小干扰RNA分子(SiRNA)的序列的任何部份或全部经化学修饰后所形成的的小干扰RNA分子。
所述化学修饰包括主要包括以下三类:第一、对连接相邻两个核苷酸的磷酸二酯键的部份修饰或用其它任何化学键取代。典型的磷酸二酯键的部份修饰是将磷酸双键上的氧置换成硫(硫化)或其它元素,或将磷酸单键上的氧变成氮(氮化)或其它元素和化学基团;对磷酸二酯键本身的全部取代,也包括对其本身或其部份以及和它相连的两个核糖的部份或全部改变,典型的例证是将磷酸二酯键和两个相邻的核糖变成肽键,使得核酸变成肽核酸(peptide nucleicacid,PNA);第二、对核甘中核糖的五元环进行改变或其侧链上的化学基团作修饰。改变核糖环的典型例证如将五元的核糖环变成六环的Morpholino环;对核糖侧链上的修饰主要是指将核糖2’位上OH变成其它元素(如卤素元素),或用其它化学基团替代OH中的H(例如烷基)。第三、将核苷酸上的碱基环作整体的改变或侧链的修饰。
本发明所提供的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)可以应用于制备治疗SARS以及与SARS感染相关的任何疾病的药物中。
附图说明
图1为SiRNA在自动核酸合成仪上每加上一个核甘酸所进行的四步反应示意图。
图2为在Beckman PACE 5010上分析得到的序号2 SiRNA的毛细管凝胶电泳法结果。其中横坐标表示滞留时间,纵坐标表示紫外吸收度。
具体实施方式
实施例1
本发明提供的小干扰RNA分子(SiRNA)的制备方法采用现有的固相化学合成法。该方法可参见:Wincott F, DiRenzo A,Shaffer C,Grimm S,Tracz D,Workman C,Sweedler D,Gonzalez C,Scaringe S and Usman N.Synthesis,deprotection,analysis and purification of RNA and ribozymes. Nucleic AcidsRes. 1995,23:2677-84。
以表1之序号2的小干扰RNA分子(SiRNA)为例:整个化学合成可大致分成四个的过程(1)寡聚核糖核酸的合成;(2)脱保护;(3)纯化分离;(4)脱盐退火无菌消毒。
具体制备操作如下:
(1)、寡聚核糖核酸的合成:SiRNA的合成是在自动DNA/RNA合成仪(例如:Applied Biosystems EXPEDITE 8909)上进行,根据序号2的小干扰RNA分子SiRNA的核酸序列(正义链5’-CUAAUUGCUGUCGCUUCCATT反义链5’-UGGAAGCGACAGCAAUUAGTT)的次序将对应的核苷酸逐个连接起来。由于SiRNA是由一段19聚的寡聚核糖核酸和一个2聚的脱氧胸苷酸组成。因此起始物为固相(CPG)连接的5’-O-对二甲氧基三苯甲基-胸苷(1-2umol)。具体每一个循环合成可分为四步来完成(图1)。第一步是将与固相连接的胸苷上5’位的保护基在3%三氯乙酸的作用下洗脱;第二步在活性催化剂S-乙基四唑的作用下,将5’-O-对二甲氧基三苯甲基-胸苷亚磷酰胺偶联到已脱去保护的上一个胸苷上,形成二胸苷亚磷酸三酯。偶合时间和偶合循环的次数均按仪器厂家提供程序来完成;第三步是将偶合的二胸苷亚磷酸三酯在0.05M碘水的作用下氧化成二胸苷磷酸三酯;第四步是乙酰化,将固相上的少量未反应的活性基团(例如:羟基和胺基)在乙酸酐的作用下形成酯或酰胺。从而达到封闭作用,用以减少整体副产物的产生。重复此循环直至完成全部核酸序列的合成。
(1)脱保护:将合成好的固相SiRNA放入一个可以密封的小瓶,并与加入1毫升的甲胺水溶液(10M,50%乙醇),静置在室温。两小时后,取出溶液,并将固相CPG再次用乙醇;水和乙腈的混合液淋洗,并将淋洗液和前面取出的溶液合并一处,将其溶剂抽干。在小瓶中继续加入1毫升四丁基氟化铵的四氢呋喃溶液(1M)。将溶液在室温静置12个小时。脱去所有寡聚核糖核酸上的保护基(包括碱基,核苷磷酸和核苷2’位的硅烷化保护基)。再经过乙醇沉淀,产生SiRNA的粗产物。
(2)纯化分离:将SiRNA的粗产物溶解在2毫升的乙酸铵的水溶液中,然后经过反相C18高压液相色谱的分离。运用梯度淋洗的方法,收集SiRNA的主产物(淋洗液A:0.1M的乙酸铵;淋洗液b:20%的0.1M的乙酸铵和80%的乙腈)。将SiRNA的主产物的溶剂除去,并加入5毫升80%乙酸水溶液,在室温静置15分钟。然后将此溶液进行阴离子交换的分离(DEAE-5PW,阴离子交换柱),即可得到纯度在90%以上的SiRNA(梯度淋洗,淋洗液A:0.025M的Tris-HCl,0.025M NaCl pH=8,5%乙腈;淋洗液b:0.025M的Tris-HCl,2.0M NaCl,pH=8,5%乙腈)。
(3)脱盐退火无菌消毒:纯化的SiRNA经过透析,除去盐份,SiRNA的溶液进行过滤消毒和干燥结晶。然后将正义链和反义链的寡聚核糖核酸进行退火处理形成稳定的双股交链的SiRNA。其方法是将正义链和反义链的寡聚核糖核酸混合溶解在1-2毫升的缓冲溶液中(10mM Tris,pH=7.5-8.0,50mM NaCl)。将此溶液加热到95℃,然后缓缓将此溶液冷却致室温(此过程应不少于一个小时)。最后将此溶液存放在4℃冰箱中保存,以便随时可以使用。
经过纯化后的SiRNA的纯度和鉴定有两种比较常用的办法。其一用毛细管凝胶电泳法来鉴定SiRNA的纯度,该方法可参见Paulus A,Ohms JI.Analysis ofoligonucleotides by capillary gelelectrophoresis.J Chromatogr1990,507:113-123。
对序号2的小干扰RNA分子的制备结果表明它的纯度大于95%(图2)。
其二是用MALDI-TOF质谱来准确测量其分子量,从而确定SiRNA的化学结构组成。
本发明所说的SiRNA都可以根据其序列采用上述方法制备,鉴定方法同上。
实施例2
如上所述,修饰的种类可分三大类并且每一类中有许多变化,因此它们各自的合成方法不尽一样。这里列举两种最为常见的SiRNA修饰方法。并且,下述的方法并不限定本发明所述的有关对SiRNA修饰的保护范围。
1、硫化
硫化是指将核苷磷酸二酯键上的一个氧原子转变成硫原子形成核苷硫代磷酸二酯。由于整个SiRNA的其它组成结构没有变化,因此它的合成和实施例1的SiRNA合成过程基本一样。只需将合成过程中的氧化反应变成硫化反应,在此反应中加入适当的硫化试剂,例如3H-1,2-benzodithiol-3-one 1,1-dioxide(又称Beaucage试剂)。
2、核苷2’位羟基的修饰
核苷2’位羟基的修饰是指用各种饱和烷氧基或不饱和烷氧来取代核苷五员糖环上的2’位羟基。其中最常见的是用甲氧基来取代核苷2’位的羟基。SiRNA的核苷2’位甲氧基化的合成和实施例1的SiRNA的合成步骤基本一致,只需要在偶合反应中用2’-甲氧基核苷亚磷酰胺来取代2’-叔丁基二甲基硅氧基核苷亚磷酰胺即可。
序列表
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>1
<211>29744
<212>RNA
<213>Coronavirus
<220>
<221>misc_feature
<222>1...29744
<223>从已知SARS病毒全基因组RNA序列得到的SARS病毒的全基因组RNA的共同序列
<400>1
atattaggtt tttacctacc caggaaaagc caaccaacct cgatctcttg tagatctgtt 60
ctctaaacga actttaaaat ctgtgtagct gtcgctcggc tgcatgccta gtgcacctac 120
gcagtataaa caataataaa ttttactgtc gttgacaaga aacgagtaac tcgtccctct 180
tctgcagact gcttacggtt tcgtccgtgt tgcagtcgat catcagcata cctaggtttc 240
gtccgggtgt gaccgaaagg taagatggag agccttgttc ttggtgtcaa cgagaaaaca 300
cacgtccaac tcagtttgcc tgtccttcag gttagagacg tgctagtgcg tggcttcggg 360
gactctgtgg aagaggccct atcggaggca cgtgaacacc tcaaaaatgg cacttgtggt 420
ctagtagagc tggaaaaagg cgtactgccc cagcttgaac agccctatgt gttcattaaa 480
cgttctgatg ccttaagcac caatcacggc cacaaggtcg ttgagctggt tgcagaaatg 540
gacggcattc agtacggtcg tagcggtata acactgggag tactcgtgcc acatgtgggc 600
gaaaccccaa ttgcataccg caatgttctt cttcgtaaga acggtaataa gggagccggt 660
ggtcatagct atggcatcga tctaaagtct tatgacttag gtgacgagct tggcactgat 720
cccattgaag attatgaaca aaactggaac actaagcatg gcagtggtgc actccgtgaa 780
ctcactcgtg agctcaatgg aggtgcagtc actcgctatg tcgacaacaa tttctgtggc 840
ccagatgggt accctcttga ttgcatcaaa gattttctcg cacgcgcggg caagtcaatg 900
tgcactcttt ccgaacaact tgattacatc gagtcgaaga gaggtgtcta ctgctgccgt 960
gaccatgagc atgaaattgc ctggttcact gagcgctctg ataagagcta cgagcaccag 1020
acacccttcg aaattaagag tgccaagaaa tttgacactt tcaaagggga atgcccaaag 1080
tttgtgtttc ctcttaactc aaaagtcaaa gtcattcaac cacgtgttga aaagaaaaag 1140
actgagggtt tcatggggcg tatacgctct gtgtaccctg ttgcatctcc acaggagtgt 1200
aacaatatgc acttgtctac cttgatgaaa tgtaatcatt gcgatgaagt ttcatggcag 1260
acgtgcgact ttctgaaagc cacttgtgaa cattgtggca ctgaaaattt agttattgaa 1320
ggacctacta catgtgggta cctacctact aatgctgtag tgaaaatgcc atgtcctgcc 1380
tgtcaagacc cagagattgg acctgagcat agtgttgcag attatcacaa ccactcaaac 1440
attgaaactc gactccgcaa gggaggtagg actagatgtt ttggaggctg tgtgtttgcc 1500
tatgttggct gctataataa gcgtgcctac tgggttcctc gtgctagtgc tgatattggc 1560
tcaggccata ctggcattac tggtgacaat gtggagacct tgaatgagga tctccttgag 1620
atactgagtc gtgaacgtgt taacattaac attgttggcg attttcattt gaatgaagag 1680
gttgccatca ttttggcatc tttctctgct tctacaagtg cctttattga cactataaag 1740
agtcttgatt acaagtcttt caaaaccatt gttgagtcct gcggtaacta taaagttacc 1800
aagggaaagc ccgtaaaagg tgcttggaac attggacaac agagatcagt tttaacacca 1860
ctgtgtggtt ttccctcaca ggctgctggt gttatcagat caatttttgc gcgcacactt 1920
gatgcagcaa accactcaat tcctgatttg caaagagcag ctgtcaccat acttgatggt 1980
atttctgaac agtcattacg tcttgtcgac gccatggttt atacttcaga cctgctcacc 2040
aacagtgtca ttattatggc atatgtaact ggtggtcttg tacaacagac ttctcagtgg 2100
ttgtctaatc ttttgggcac tactgttgaa aaactcaggc ctatctttga atggattgag 2160
gcgaaactta gtgcaggagt tgaatttctc aaggatgctt gggagattct caaatttctc 2220
attacaggtg tttttgacat cgtcaagggt caaatacagg ttgcttcaga taacatcaag 2280
gattgtgtaa aatgcttcat tgatgttgtt aacaaggcac tcgaaatgtg cattgatcaa 2340
gtcactatcg ctggcgcaaa gttgcgatca ctcaacttag gtgaagtctt catcgctcaa 2400
agcaagggac tttaccgtca gtgtatacgt ggcaaggagc agctgcaact actcatgcct 2460
cttaaggcac caaaagaagt aacctttctt gaaggtgatt cacatgacac agtacttacc 2520
tctgaggagg ttgttctcaa gaacggtgaa ctcgaagcac tcgagacgcc cgttgatagc 2580
ttcacaaatg gagctatcgt tggcacacca gtctgtgtaa atggcctcat gctcttagag 2640
attaaggaca aagaacaata ctgcgcattg tctcctggtt tactggctac aaacaatgtc 2700
tttcgcttaa aagggggtgc accaattaaa ggtgtaacct ttggagaaga tactgtttgg 2760
gaagttcaag gttacaagaa tgtgagaatc acatttgagc ttgatgaacg tgttgacaaa 2820
gtgcttaatg aaaagtgctc tgtctacact gttgaatccg gtaccgaagt tactgagttt 2880
gcatgtgttg tagcagaggc tgttgtgaag actttacaac cagtttctga tctccttacc 2940
aacatgggta ttgatcttga tgagtggagt gtagctacat tctacttatt tgatgatgct 3000
ggtgaagaaa acttttcatc acgtatgtat tgttcctttt accctccaga tgaggaagaa 3060
gaggacgatg cagagtgtga ggaagaagaa attgatgaaa cctgtgaaca tgagtacggt 3120
acagaggatg attatcaagg tctccctctg gaatttggtg cctcagctga aacagttcga 3180
gttgaggaag aagaagagga agactggctg gatgatacta ctgagcaatc agagattgag 3240
ccagaaccag aacctacacc tgaagaacca gttaatcagt ttactggtta tttaaaactt 3300
actgacaatg ttgccattaa atgtgttgac atcgttaagg aggcacaaag tgctaatcct 3360
atggtgattg taaatgctgc taacatacac ctgaaacatg gtggtggtgt agcaggtgca 3420
ctcaacaagg caaccaatgg tgccatgcaa aaggagagtg atgattacat taagctaaat 3480
ggccctctta cagtaggagg gtcttgtttg ctttctggac ataatcttgc taagaagtgt 3540
ctgcatgttg ttggacctaa cctaaatgca ggtgaggaca tccagcttct taaggcagca 3600
tatgaaaatt tcaattcaca ggacatctta cttgcaccat tgttgtcagc aggcatattt 3660
ggtgctaaac cacttcagtc tttacaagtg tgcgtgcaga cggttcgtac acaggtttat 3720
attgcagtca atgacaaagc tctttatgag caggttgtca tggattatct tgataacctg 3780
aagcctagag tggaagcacc taaacaagag gagccaccaa acacagaaga ttccaaaact 3840
gaggagaaat ctgtcgtaca gaagcctgtc gatgtgaagc caaaaattaa ggcctgcatt 3900
gatgaggtta ccacaacact ggaagaaact aagtttctta ccaataagtt actcttgttt 3960
gctgatatca atggtaagct ttaccatgat tctcagaaca tgcttagagg tgaagatatg 4020
tctttccttg agaaggatgc accttacatg gtaggtgatg ttatcactag tggtgatatc 4080
acttgtgttg taataccctc caaaaaggct ggtggcacta ctgagatgct ctcaagagct 4140
ttgaagaaag tgccagttga tgagtatata accacgtacc ctggacaagg atgtgctggt 4200
tatacacttg aggaagctaa gactgctctt aagaaatgca aatctgcatt ttatgtacta 4260
ccttcagaag cacctaatgc taaggaagag attctaggaa ctgtatcctg gaatttgaga 4320
gaaatgcttg ctcatgctga agagacaaga aaattaatgc ctatatgcat ggatgttaga 4380
gccataatgg caaccatcca acgtaagtat aaaggaatta aaattcaaga gggcatcgtt 4440
gactatggtg tccgattctt cttttatact agtaaagagc ctgtagcttc tattattacg 4500
aagctgaact ctctaaatga gccgcttgtc acaatgccaa ttggttatgt gacacatggt 4560
tttaatcttg aagaggctgc gcgctgtatg cgttctctta aagctcctgc cgtagtgtca 4620
gtatcatcac cagatgctgt tactacatat aatggatacc tcacttcgtc atcaaagaca 4680
tctgaggagc actttgtaga aacagtttct ttggctggct cttacagaga ttggtcctat 4740
tcaggacagc gtacagagtt aggtgttgaa tttcttaagc gtggtgacaa aattgtgtac 4800
cacactctgg agagccccgt cgagtttcat cttgacggtg aggttctttc acttgacaaa 4860
ctaaagagtc tcttatccct gcgggaggtt aagactataa aagtgttcac aactgtggac 4920
aacactaatc tccacacaca gcttgtggat atgtctatga catatggaca gcagtttggt 4980
ccaacatact tggatggtgc tgatgttaca aaaattaaac ctcatgtaaa tcatgagggt 5040
aagactttct ttgtactacc tagtgatgac acactacgta gtgaagcttt cgagtactac 5100
catactcttg atgagagttt tcttggtagg tacatgtctg ctttaaacca cacaaagaaa 5160
tggaaatttc ctcaagttgg tggtttaact tcaattaaat gggctgataa caattgttat 5220
ttgtctagtg ttttattagc acttcaacag cttgaagtca aattcaatgc accagcactt 5280
caagaggctt attatagagc ccgtgctggt gatgctgcta acttttgtgc actcatactc 5340
gcttacagta ataaaactgt tggcgagctt ggtgatgtca gagaaactat gacccatctt 5400
ctacagcatg ctaatttgga atctgcaaag cgagttctta atgtggtgtg taaacattgt 5460
ggtcagaaaa ctactacctt aacgggtgta gaagctgtga tgtatatggg tactctatct 5520
tatgataatc ttaagacagg tgtttccatt ccatgtgtgt gtggtcgtga tgctacacaa 5580
tatctagtac aacaagagtc ttcttttgtt atgatgtctg caccacctgc tgagtataaa 5640
ttacagcaag gtacattctt atgtgcgaat gagtacactg gtaactatca gtgtggtcat 5700
tacactcata taactgctaa ggagaccctc tatcgtattg acggagctca ccttacaaag 5760
atgtcagagt acaaaggacc agtgactgat gttttctaca aggaaacatc ttacactaca 5820
accatcaagc ctgtgtcgta taaactcgat ggagttactt acacagagat tgaaccaaaa 5880
ttggatgggt attataaaaa ggataatgct tactatacag agcagcctat agaccttgta 5940
ccaactcaac cattaccaaa tgcgagtttt gataatttca aactcacatg ttctaacaca 6000
aaatttgctg atgatttaaa tcaaatgaca ggcttcacaa agccagcttc acgagagcta 6060
tctgtcacat tcttcccaga cttgaatggc gatgtagtgg ctattgacta tagacactat 6120
tcagcgagtt tcaagaaagg tgctaaatta ctgcataagc caattgtttg gcacattaac 6180
caggctacaa ccaagacaac gttcaaacca aacacttggt gtttacgttg tctttggagt 6240
acaaagccag tagatacttc aaattcattt gaagttctgg cagtagaaga cacacaagga 6300
atggacaatc ttgcttgtga aagtcaacaa cccacctctg aagaagtagt ggaaaatcct 6360
accatacaga aggaagtcat agagtgtgac gtgaaaacta ccgaagttgt aggcaatgtc 6420
atacttaaac catcagatga aggtgttaaa gtaacacaag agttaggtca tgaggatctt 6480
atggctgctt atgtggaaaa cacaagcatt accattaaga aacctaatga gctttcacta 6540
gccttaggtt taaaaacaat tgccactcat ggtattgctg caattaatag tgttccttgg 6600
agtaaaattt tggcttatgt caaaccattc ttaggacaag cagcaattac aacatcaaat 6660
tgcgctaaga gattagcaca acgtgtgttt aacaattata tgccttatgt gtttacatta 6720
ttgttccaat tgtgtacttt tactaaaagt accaattcta gaattagagc ttcactacct 6780
acaactattg ctaaaaatag tgttaagagt gttgctaaat tatgtttgga tgccggcatt 6840
aattatgtga agtcacccaa attttctaaa ttgttcacaa tcgctatgtg gctattgttg 6900
ttaagtattt gcttaggttc tctaatctgt gtaactgctg cttttggtgt actcttatct 6960
aattttggtg ctccttctta ttgtaatggc gttagagaat tgtatcttaa ttcgtctaac 7020
gttactacta tggatttctg tgaaggttct tttccttgca gcatttgttt aagtggatta 7080
gactcccttg attcttatcc agctcttgaa accattcagg tgacgatttc atcgtacaag 7140
ctagacttga caattttagg tctggccgct gagtgggttt tggcatatat gttgttcaca 7200
aaattctttt atttattagg tctttcagct ataatgcagg tgttctttgg ctattttgct 7260
agtcatttca tcagcaattc ttggctcatg tggtttatca ttagtattgt acaaatggca 7320
cccgtttctg caatggttag gatgtacatc ttctttgctt ctttctacta catatggaag 7380
agctatgttc atatcatgga tggttgcacc tcttcgactt gcatgatgtg ctataagcgc 7440
aatcgtgcca cacgcgttga gtgtacaact attgttaatg gcatgaagag atctttctat 7500
gtctatgcaa atggaggccg tggcttctgc aagactcaca attggaattg tctcaattgt 7560
gacacatttt gcactggtag tacattcatt agtgatgaag ttgctcgtga tttgtcactc 7620
cagtttaaaa gaccaatcaa ccctactgac cagtcatcgt atattgttga tagtgttgct 7680
gtgaaaaatg gcgcgcttca cctctacttt gacaaggctg gtcaaaagac ctatgagaga 7740
catccgctct cccattttgt caatttagac aatttgagag ctaacaacac taaaggttca 7800
ctgcctatta atgtcatagt ttttgatggc aagtccaaat gcgacgagtc tgcttctaag 7860
tctgcttctg tgtactacag tcagctgatg tgccaaccta ttctgttgct tgaccaagct 7920
cttgtatcag acgttggaga tagtactgaa gtttccgtta agatgtttga tgcttatgtc 7980
gacacctttt cagcaacttt tagtgttcct atggaaaaac ttaaggcact tgttgctaca 8040
gctcacagcg agttagcaaa gggtgtagct ttagatggtg tcctttctac attcgtgtca 8100
gctgcccgac aaggtgttgt tgataccgat gttgacacaa aggatgttat tgaatgtctc 8160
aaactttcac atcactctga cttagaagtg acaggtgaca gttgtaacaa tttcatgctc 8220
acctataata aggttgaaaa catgacgccc agagatcttg gcgcatgtat tgactgtaat 8280
gcaaggcata tcaatgccca agtagcaaaa agtcacaatg tttcactcat ctggaatgta 8340
aaagactaca tgtctttatc tgaacagctg cgtaaacaaa ttcgtagtgc tgccaagaag 8400
aacaacatac cttttagact aacttgtgct acaactagac aggttgtcaa tgtcataact 8460
actaaaatct cactcaaggg tggtaagatt gttagtactt gttttaaact tatgcttaag 8520
gccacattat tgtgcgttct tgctgcattg gtttgttata tcgttatgcc agtacataca 8580
ttgtcaatcc atgatggtta cacaaatgaa atcattggtt acaaagccat tcaggatggt 8640
gtcactcgtg acatcatttc tactgatgat tgttttgcaa ataaacatgc tggttttgac 8700
gcatggttta gccagcgtgg tggttcatac aaaaatgaca aaagctgccc tgtagtagct 8760
gctatcatta caagagagat tggtttcata gtgcctggct taccgggtac tgtgctgaga 8820
gcaatcaatg gtgacttctt gcattttcta cctcgtgttt ttagtgctgt tggcaacatt 8880
tgctacacac cttccaaact cattgagtat agtgattttg ctacctctgc ttgcgttctt 8940
gctgctgagt gtacaatttt taaggatgct atgggcaaac ctgtgccata ttgttatgac 9000
actaatttgc tagagggttc tatttcttat agtgagcttc gtccagacac tcgttatgtg 9060
cttatggatg gttccatcat acagtttcct aacacttacc tggagggttc tgttagagta 9120
gtaacaactt ttgatgctga gtactgtaga catggtacat gcgaaaggtc agaagtaggt 9180
atttgcctat ctaccagtgg tagatgggtt cttaataatg agcattacag agctctatca 9240
ggagttttct gtggtgttga tgcgatgaat ctcatagcta acatctttac tcctcttgtg 9300
caacctgtgg gtgctttaga tgtgtctgct tcagtagtgg ctggtggtat tattgccata 9360
ttggtgactt gtgctgccta ctactttatg aaattcagac gtgtttttgg tgagtacaac 9420
catgttgttg ctgctaatgc acttttgttt ttgatgtctt tcactatact ctgtctggta 9480
ccagcttaca gctttctgcc gggagtctac tcagtctttt acttgtactt gacattctat 9540
ttcaccaatg atgtttcatt cttggctcac cttcaatggt ttgccatgtt ttctcctatt 9600
gtgccttttt ggataacagc aatctatgta ttctgtattt ctctgaagca ctgccattgg 9660
ttctttaaca actatcttag gaaaagagtc atgtttaatg gagttacatt tagtaccttc 9720
gaggaggctg ctttgtgtac ctttttgctc aacaaggaaa tgtacctaaa attgcgtagc 9780
gagacactgt tgccacttac acagtataac aggtatcttg ctctatataa caagtacaag 9840
tatttcagtg gagccttaga tactaccagc tatcgtgaag cagcttgctg ccacttagca 9900
aaggctctaa atgactttag caactcaggt gctgatgttc tctaccaacc accacagaca 9960
tcaatcactt ctgctgttct gcagagtggt tttaggaaaa tggcattccc gtcaggcaaa 10020
gttgaagggt gcatggtaca agtaacctgt ggaactacaa ctcttaatgg attgtggttg 10080
gatgacacag tatactgtcc aagacatgtc atttgcacag cagaagacat gcttaatcct 10140
aactatgaag atctgctcat tcgcaaatcc aaccatagct ttcttgttca ggctggcaat 10200
gttcaacttc gtgttattgg ccattctatg caaaattgtc tgcttaggct taaagttgat 10260
acttctaacc ctaagacacc caagtataaa tttgtccgta tccaacctgg tcaaacattt 10320
tcagttctag catgctacaa tggttcacca tctggtgttt atcagtgtgc catgagacct 10380
aatcatacca ttaaaggttc tttccttaat ggatcatgtg gtagtgttgg ttttaacatt 10440
gattatgatt gcgtgtcttt ctgctatatg catcatatgg agcttccaac aggagtacac 10500
gctggtactg acttagaagg taaattctat ggtccatttg ttgacagaca aactgcacag 10560
gctgcaggta cagacacaac cataacatta aatgttttgg catggctgta tgctgctgtt 10620
atcaatggtg ataggtggtt tcttaataga ttcaccacta ctttgaatga ctttaacctt 10680
gtggcaatga agtacaacta tgaacctttg acacaagatc atgttgacat attgggacct 10740
ctttctgctc aaacaggaat tgccgtctta gatatgtgtg ctgctttgaa agagctgctg 10800
cagaatggta tgaatggtcg tactatcctt ggtagcacta ttttagaaga tgagtttaca 10860
ccatttgatg ttgttagaca atgctctggt gttaccttcc aaggtaagtt caagaaaatt 10920
gttaagggca ctcatcattg gatgctttta actttcttga catcactatt gattcttgtt 10980
caaagtacac agtggtcact gtttttcttt gtttacgaga atgctttctt gccatttact 11040
cttggtatta tggcaattgc tgcatgtgct atgctgcttg ttaagcataa gcacgcattc 11100
ttgtgcttgt ttctgttacc ttctcttgca acagttgctt actttaatat ggtctacatg 11160
cctgctagct gggtgatgcg tatcatgaca tggcttgaat tggctgacac tagcttgtct 11220
ggttataggc ttaaggattg tgttatgtat gcttcagctt tagttttgct tattctcatg 11280
acagctcgca ctgtttatga tgatgctgct agacgtgttt ggacactgat gaatgtcatt 11340
acacttgttt acaaagtcta ctatggtaat gctttagatc aagctatttc catgtgggcc 11400
ttagttattt ctgtaacctc taactattct ggtgtcgtta cgactatcat gtttttagct 11460
agagctatag tgtttgtgtg tgttgagtat tacccattgt tatttattac tggcaacacc 11520
ttacagtgta tcatgcttgt ttattgtttc ttaggctatt gttgctgctg ctactttggc 11580
cttttctgtt tactcaaccg ttacttcagg cttactcttg gtgtttatga ctacttggtc 11640
tctacacaag aatttaggta tatgaactcc caggggcttt tgcctcctaa gagtagtatt 11700
gatgctttca agcttaacat taagttgttg ggtattggag gtaaaccatg tatcaaggtt 11760
gctactgtac agtctaaaat gtctgacgta aagtgcacat ctgtggtact gctctcggtt 11820
cttcaacaac ttagagtaga gtcatcttct aaattgtggg cacaatgtgt acaactccac 11880
aatgatattc ttcttgcaaa agacacaact gaagctttcg agaagatggt ttctcttttg 11940
tctgttttgc tatccatgca gggtgctgta gacattaata ggttgtgcga ggaaatgctc 12000
gataaccgtg ctactcttca ggctattgct tcagaattta gttctttacc atcatatgcc 12060
gcttatgcca ctgcccagga ggcctatgag caggctgtag ctaatggtga ttctgaagtc 12120
gttctcaaaa agttaaagaa atctttgaat gtggctaaat ctgagtttga ccgtgatgct 12180
gccatgcaac gcaagttgga aaagatggca gatcaggcta tgacccaaat gtacaaacag 12240
gcaagatctg aggacaagag ggcaaaagta actagtgcta tgcaaacaat gctcttcact 12300
atgcttagga agcttgataa tgatgcactt aacaacatta tcaacaatgc gcgtgatggt 12360
tgtgttccac tcaacatcat accattgact acagcagcca aactcatggt tgttgtccct 12420
gattatggta cctacaagaa cacttgtgat ggtaacacct ttacatatgc atctgcactc 12480
tgggaaatcc agcaagttgt tgatgcggat agcaagattg ttcaacttag tgaaattaac 12540
atggacaatt caccaaattt ggcttggcct cttattgtta cagctctaag agccaactca 12600
gctgttaaac tacagaataa tgaactgagt ccagtagcac tacgacagat gtcctgtgcg 12660
gctggtacca cacaaacagc ttgtactgat gacaatgcac ttgcctacta taacaattcg 12720
aagggaggta ggtttgtgct ggcattacta tcagaccacc aagatctcaa atgggctaga 12780
ttccctaaga gtgatggtac aggtacaatt tacacagaac tggaaccacc ttgtaggttt 12840
gttacagaca caccaaaagg gcctaaagtg aaatacttgt acttcatcaa aggcttaaac 12900
aacctaaata gaggtatggt gctgggcagt ttagctgcta cagtacgtct tcaggctgga 12960
aatgctacag aagtacctgc caattcaact gtgctttcct tctgtgcttt tgcagtagac 13020
cctgctaaag catataagga ttacctagca agtggaggac aaccaatcac caactgtgtg 13080
aagatgttgt gtacacacac tggtacagga caggcaatta ctgtaacacc agaagctaac 13140
atggaccaag agtcctttgg tggtgcttca tgttgtctgt attgtagatg ccacattgac 13200
catccaaatc ctaaaggatt ctgtgacttg aaaggtaagt acgtccaaat acctaccact 13260
tgtgctaatg acccagtggg ttttacactt agaaacacag tctgtaccgt ctgcggaatg 13320
tggaaaggtt atggctgtag ttgtgaccaa ctccgcgaac ccttgatgca gtctgcggat 13380
gcatcaacgt ttttaaacgg gtttgcggtg taagtgcagc ccgtcttaca ccgtgcggca 13440
caggcactag tactgatgtc gtctacaggg cttttgatat ttacaacgaa aaagttgctg 13500
gttttgcaaa gttcctaaaa actaattgct gtcgcttcca ggagaaggat gaggaaggca 13560
atttattaga ctcttacttt gtagttaaga ggcatactat gtctaactac caacatgaag 13620
agactattta taacttggtt aaagattgtc cagcggttgc tgtccatgac tttttcaagt 13680
ttagagtaga tggtgacatg gtaccacata tatcacgtca gcgtctaact aaatacacaa 13740
tggctgattt agtctatgct ctacgtcatt ttgatgaggg taattgtgat acattaaaag 13800
aaatactcgt cacatacaat tgctgtgatg atgattattt caataagaag gattggtatg 13860
acttcgtaga gaatcctgac atcttacgcg tatatgctaa cttaggtgag cgtgtacgcc 13920
aatcattatt aaagactgta caattctgcg atgctatgcg tgatgcaggc attgtaggcg 13980
tactgacatt agataatcag gatcttaatg ggaactggta cgatttcggt gatttcgtac 14040
aagtagcacc aggctgcgga gttcctattg tggattcata ttactcattg ctgatgccca 14100
tcctcacttt gactagggca ttggctgctg agtcccatat ggatgctgat ctcgcaaaac 14160
cacttattaa gtgggatttg ctgaaatatg attttacgga agagagactt tgtctcttcg 14220
accgttattt taaatattgg gaccagacat accatcccaa ttgtattaac tgtttggatg 14280
ataggtgtat ccttcattgt gcaaacttta atgtgttatt ttctactgtg tttccaccta 14340
caagttttgg accactagta agaaaaatat ttgtagatgg tgttcctttt gttgtttcaa 14400
ctggatacca ttttcgtgag ttaggagtcg tacataatca ggatgtaaac ttacatagct 14460
cgcgtctcag tttcaaggaa cttttagtgt atgctgctga tccagctatg catgcagctt 14520
ctggcaattt attgctagat aaacgcacta catgcttttc agtagctgca ctaacaaaca 14580
atgttgcttt tcaaactgtc aaacccggta attttaataa agacttttat gactttgctg 14640
tgtctaaagg tttctttaag gaaggaagtt ctgttgaact aaaacacttc ttctttgctc 14700
aggatggcaa cgctgctatc agtgattatg actattatcg ttataatctg ccaacaatgt 14760
gtgatatcag acaactccta ttcgtagttg aagttgttga taaatacttt gattgttacg 14820
atggtggctg tattaatgcc aaccaagtaa tcgttaacaa tctggataaa tcagctggtt 14880
tcccatttaa taaatggggt aaggctagac tttattatga ctcaatgagt tatgaggatc 14940
aagatgcact tttcgcgtat actaagcgta atgtcatccc tactataact caaatgaatc 15000
ttaagtatgc cattagtgca aagaatagag ctcgcaccgt agctggtgtc tctatctgta 15060
gtactatgac aaatagacag tttcatcaga aattattgaa gtcaatagcc gccactagag 15120
gagctactgt ggtaattgga acaagcaagt tttacggtgg ctggcataat atgttaaaaa 15180
ctgtttacag tgatgtagaa actccacacc ttatgggttg ggattatcca aaatgtgaca 15240
gagccatgcc taacatgctt aggataatgg cctctcttgt tcttgctcgc aaacataaca 15300
cttgctgtaa cttatcacac cgtttctaca ggttagctaa cgagtgtgcg caagtattaa 15360
gtgagatggt catgtgtggc ggctcactat atgttaaacc aggtggaaca tcatccggtg 15420
atgctacaac tgcttatgct aatagtgtct ttaacatttg tcaagctgtt acagccaatg 15480
taaatgcact tctttcaact gatggtaata agatagctga caagtatgtc cgcaatctac 15540
aacacaggct ctatgagtgt ctctatagaa atagggatgt tgatcatgaa ttcgtggatg 15600
agttttacgc ttacctgcgt aaacatttct ccatgatgat tctttctgat gatgccgttg 15660
tgtgctataa cagtaactat gcggctcaag gtttagtagc tagcattaag aactttaagg 15720
cagttcttta ttatcaaaat aatgtgttca tgtctgaggc aaaatgttgg actgagactg 15780
accttactaa aggacctcac gaattttgct cacagcatac aatgctagtt aaacaaggag 15840
atgattacgt gtacctgcct tacccagatc catcaagaat attaggcgca ggctgttttg 15900
tcgatgatat tgtcaaaaca gatggtacac ttatgattga aaggttcgtg tcactggcta 15960
ttgatgctta cccacttaca aaacatccta atcaggagta tgctgatgtc tttcacttgt 16020
atttacaata cattagaaag ttacatgatg agcttactgg ccacatgttg gacatgtatt 16080
ccgtaatgct aactaatgat aacacctcac ggtactggga acctgagttt tatgaggcta 16140
tgtacacacc acatacagtc ttgcaggctg taggtgcttg tgtattgtgc aattcacaga 16200
cttcacttcg ttgcggtgcc tgtattagga gaccattcct atgttgcaag tgctgctatg 16260
accatgtcat ttcaacatca cacaaattag tgttgtctgt taatccctat gtttgcaatg 16320
ccccaggttg tgatgtcact gatgtgacac aactgtatct aggaggtatg agctattatt 16380
gcaagtcaca taagcctccc attagttttc cattatgtgc taatggtcag gtttttggtt 16440
tatacaaaaa cacatgtgta ggcagtgaca atgtcactga cttcaatgcg atagcaacat 16500
gtgattggac taatgctggc gattacatac ttgccaacac ttgtactgag agactcaagc 16560
ttttcgcagc agaaacgctc aaagccactg aggaaacatt taagctgtca tatggtattg 16620
ccactgtacg cgaagtactc tctgacagag aattgcatct ttcatgggag gttggaaaac 16680
ctagaccacc attgaacaga aactatgtct ttactggtta ccgtgtaact aaaaatagta 16740
aagtacagat tggagagtac acctttgaaa aaggtgacta tggtgatgct gttgtgtaca 16800
gaggtactac gacatacaag ttgaatgttg gtgattactt tgtgttgaca tctcacactg 16860
taatgccact tagtgcacct actctagtgc cacaagagca ctatgtgaga attactggct 16920
tgtacccaac actcaacatc tcagatgagt tttctagcaa tgttgcaaat tatcaaaagg 16980
tcggcatgca aaagtactct acactccaag gaccacctgg tactggtaag agtcattttg 17040
ccatcggact tgctctctat tacccatctg ctcgcatagt gtatacggca tgctctcatg 17100
cagctgttga tgccctatgt gaaaaggcat taaaatattt gcccatagat aaatgtagta 17160
gaatcatacc tgcgcgtgcg cgcgtagagt gttttgataa attcaaagtg aattcaacac 17220
tagaacagta tgttttctgc actgtaaatg cattgccaga aacaactgct gacattgtag 17280
tctttgatga aatctctatg gctactaatt atgacttgag tgttgtcaat gctagacttc 17340
gtgcaaaaca ctacgtctat attggcgatc ctgctcaatt accagccccc cgcacattgc 17400
tgactaaagg cacactagaa ccagaatatt ttaattcagt gtgcagactt atgaaaacaa 17460
taggtccaga catgttcctt ggaacttgtc gccgttgtcc tgctgaaatt gttgacactg 17520
tgagtgcttt agtttatgac aataagctaa aagcacacaa ggataagtca gctcaatgct 17580
tcaaaatgtt ctacaaaggt gttattacac atgatgtttc atctgcaatc aacagacctc 17640
aaataggcgt tgtaagagaa tttcttacac gcaatcctgc ttggagaaaa gctgttttta 17700
tctcacctta taattcacag aacgctgtag cttcaaaaat cttaggattg cctacgcaga 17760
ctgttgattc atcacagggt tctgaatatg actatgtcat attcacacaa actactgaaa 17820
cagcacactc ttgtaatgtc aaccgcttca atgtggctat cacaagggca aaaattggca 17880
ttttgtgcat aatgtctgat agagatcttt atgacaaact gcaatttaca agtctagaaa 17940
taccacgtcg caatgtggct acattacaag cagaaaatgt aactggactt tttaaggact 18000
gtagtaagat cattactggt cttcatccta cacaggcacc tacacacctc agcgttgata 18060
taaagttcaa gactgaagga ttatgtgttg acataccagg cataccaaag gacatgacct 18120
accgtagact catctctatg atgggtttca aaatgaatta ccaagtcaat ggttacccta 18180
atatgtttat cacccgcgaa gaagctattc gtcacgttcg tgcgtggatt ggctttgatg 18240
tagagggctg tcatgcaact agagatgctg tgggtactaa cctacctctc cagctaggat 18300
tttctacagg tgttaactta gtagctgtac cgactggtta tgttgacact gaaaataaca 18360
cagaattcac cagagttaat gcaaaacctc caccaggtga ccagtttaaa catcttatac 18420
cactcatgta taaaggcttg ccctggaatg tagtgcgtat taagatagta caaatgctca 18480
gtgatacact gaaaggattg tcagacagag tcgtgttcgt cctttgggcg catggctttg 18540
agcttacatc aatgaagtac tttgtcaaga ttggacctga aagaacgtgt tgtctgtgtg 18600
acaaacgtgc aacttgcttt tctacttcat cagatactta tgcctgctgg aatcattctg 18660
tgggttttga ctatgtctat aacccattta tgattgatgt tcagcagtgg ggctttacgg 18720
gtaaccttca gagtaaccat gaccaacatt gccaggtaca tggaaatgca catgtggcta 18780
gttgtgatgc tatcatgact agatgtttag cagtccatga gtgctttgtt aagcgcgttg 18840
attggtctgt tgaataccct attataggag atgaactgag ggttaattct gcttgcagaa 18900
aagtacaaca catggttgtg aagtctgcat tgcttgctga taagtttcca gttcttcatg 18960
acattggaaa tccaaaggct atcaagtgtg tgcctcaggc tgaagtagaa tggaagttct 19020
acgatgctca gccatgtagt gacaaagctt acaaaataga ggaactcttc tattcttatg 19080
ctacacatca cgataaattc actgatggtg tttgtttgtt ttggaattgt aacgttgatc 19140
gttacccagc caatgcaatt gtgtgtaggt ttgacacaag agtcttgtca aacttgaact 19200
taccaggctg tgatggtggt agtttgtatg tgaataagca tgcattccac actccagctt 19260
tcgataaaag tgcatttact aatttaaagc aattgccttt cttttactat tctgatagtc 19320
cttgtgagtc tcatggcaaa caagtagtgt cggatattga ttatgttcca ctcaaatctg 19380
ctacgtgtat tacacgatgc aatttaggtg gtgctgtttg cagacaccat gcaaatgagt 19440
accgacagta cttggatgca tataatatga tgatttctgc tggatttagc ctatggattt 19500
acaaacaatt tgatacttat aacctgtgga atacatttac caggttacag agtttagaaa 19560
atgtggctta taatgttgtt aataaaggac actttgatgg acacgccggc gaagcacctg 19620
tttccatcat taataatgct gtttacacaa aggtagatgg tattgatgtg gagatctttg 19680
aaaataagac aacacttcct gttaatgttg catttgagct ttgggctaag cgtaacatta 19740
aaccagtgcc agagattaag atactcaata atttgggtgt tgatatcgct gctaatactg 19800
taatctggga ctacaaaaga gaagccccag cacatgtatc tacaataggt gtctgcacaa 19860
tgactgacat tgccaagaaa cctactgaga gtgcttgttc ttcacttact gtcttgtttg 19920
atggtagagt ggaaggacag gtagaccttt ttagaaacgc ccgtaatggt gttttaataa 19980
cagaaggttc agtcaaaggt ctaacacctt caaagggacc agcacaagct agcgtcaatg 20040
gagtcacatt aattggagaa tcagtaaaaa cacagtttaa ctactttaag aaagtagacg 20100
gcattattca acagttgcct gaaacctact ttactcagag cagagactta gaggatttta 20160
agcccagatc acaaatggaa actgactttc tcgagctcgc tatggatgaa ttcatacagc 20220
gatataagct cgagggctat gccttcgaac acatcgttta tggagatttc agtcatggac 20280
aacttggcgg tcttcattta atgataggct tagccaagcg ctcacaagat tcaccactta 20340
aattagagga ttttatccct atggacagca cagtgaaaaa ttacttcata acagatgcgc 20400
aaacaggttc atcaaaatgt gtgtgttctg tgattgatct tttacttgat gactttgtcg 20460
agataataaa gtcacaagat ttgtcagtga tttcaaaagt ggtcaaggtt acaattgact 20520
atgctgaaat ttcattcatg ctttggtgta aggatggaca tgttgaaacc ttctacccaa 20580
aactacaagc aagtcaagcg tggcaaccag gtgttgcgat gcctaacttg tacaagatgc 20640
aaagaatgct tcttgaaaag tgtgaccttc agaattatgg tgaaaatgct gttataccaa 20700
aaggaataat gatgaatgtc gcaaagtata ctcaactgtg tcaatactta aatacactta 20760
ctttagctgt accctacaac atgagagtta ttcactttgg tgctggctct gataaaggag 20820
ttgcaccagg tacagctgtg ctcagacaat ggttgccaac tggcacacta cttgtcgatt 20880
cagatcttaa tgacttcgtc tccgacgcag attctacttt aattggagac tgtgcaacag 20940
tacatacggc taataaatgg gaccttatta ttagcgatat gtatgaccct aggaccaaac 21000
atgtgacaaa agagaatgac tctaaagaag ggtttttcac ttatctgtgt ggatttataa 21060
agcaaaaact agccctgggt ggttctatag ctgtaaagat aacagagcat tcttggaatg 21120
ctgaccttta caagcttatg ggccatttct catggtggac agcttttgtt acaaatgtaa 21180
atgcatcatc atcggaagca tttttaattg gggctaacta tcttggcaag ccgaaggaac 21240
aaattgatgg ctataccatg catgctaact acattttctg gaggaacaca aatcctatcc 21300
agttgtcttc ctattcactc tttgacatga gcaaatttcc tcttaaatta agaggaactg 21360
ctgtaatgtc tcttaaggag aatcaaatca atgatatgat ttattctctt ctggaaaaag 21420
gtaggcttat cattagagaa aacaacagag ttgtggtttc aagtgatatt cttgttaaca 21480
actaaacgaa catgtttatt ttcttattat ttcttactct cactagtggt agtgaccttg 21540
accggtgcac cacttttgat gatgttcaag ctcctaatta cactcaacat acttcatcta 21600
tgaggggggt ttactatcct gatgaaattt ttagatcaga cactctttat ttaactcagg 21660
atttatttct tccattttat tctaatgtta cagggtttca tactattaat catacgtttg 21720
gcaaccctgt catacctttt aaggatggta tttattttgc tgccacagag aaatcaaatg 21780
ttgtccgtgg ttgggttttt ggttctacca tgaacaacaa gtcacagtcg gtgattatta 21840
ttaacaattc tactaatgtt gttatacgag catgtaactt tgaattgtgt gacaaccctt 21900
tctttgctgt ttctaaaccc atgggtacac agacacatac tatgatattc gataatgcat 21960
ttaattgcac tttcgagtac atatctgatg ccttttcgct tgatgtttca gaaaagtcag 22020
gtaattttaa acacttacga gagtttgtgt ttaaaaataa agatgggttt ctctatgttt 22080
ataagggcta tcaacctata gatgtagttc gtgatctacc ttctggtttt aacactttga 22140
aacctatttt taagttgcct cttggtatta acattacaaa ttttagagcc attcttacag 22200
ccttttcacc tgctcaagac atttggggca cgtcagctgc agcctatttt gttggctatt 22260
taaagccaac tacatttatg ctcaagtatg atgaaaatgg tacaatcaca gatgctgttg 22320
attgttctca aaatccactt gctgaactca aatgctctgt taagagcttt gagattgaca 22380
aaggaattta ccagacctct aatttcaggg ttgttccctc aggagatgtt gtgagattcc 22440
ctaatattac aaacttgtgt ccttttggag aggtttttaa tgctactaaa ttcccttctg 22500
tctatgcatg ggagagaaaa aaaatttcta attgtgttgc tgattactct gtgctctaca 22560
actcaacatt tttttcaacc tttaagtgct atggcgtttc tgccactaag ttgaatgatc 22620
tttgcttctc caatgtctat gcagattctt ttgtagtcaa gggagatgat gtaagacaaa 22680
tagcgccagg acaaactggt gttattgctg attataatta taaattgcca gatgatttca 22740
tgggttgtgt ccttgcttgg aatactagga acattgatgc tacttcaact ggtaattata 22800
attataaata taggtatctt agacatggca agcttaggcc ctttgagaga gacatatcta 22860
atgtgccttt ctcccctgat ggcaaacctt gcaccccacc tgctcttaat tgttattggc 22920
cattaaatga ttatggtttt tacaccacta ctggcattgg ctaccaacct tacagagttg 22980
tagtactttc ttttgaactt ttaaatgcac cggccacggt ttgtggacca aaattatcca 23040
ctgaccttat taagaaccag tgtgtcaatt ttaattttaa tggactcact ggtactggtg 23100
tgttaactcc ttcttcaaag agatttcaac catttcaaca atttggccgt gatgtttctg 23160
atttcactga ttccgttcga gatcctaaaa catctgaaat attagacatt tcaccttgct 23220
cttttggggg tgtaagtgta attacacctg gaacaaatgc ttcatctgaa gttgctgttc 23280
tatatcaaga tgttaactgc actgatgttt ctacagcaat tcatgcagat caactcacac 23340
cagcttggcg catatattct actggaaaca atgtattcca gactcaagca ggctgtctta 23400
taggagctga gcatgtcgac acttcttatg agtgcgacat tcctattgga gctggcattt 23460
gtgctagtta ccatacagtt tctttattac gtagtactag ccaaaaatct attgtggctt 23520
atactatgtc tttaggtgct gatagttcaa ttgcttactc taataacacc attgctatac 23580
ctactaactt ttcaattagc attactacag aagtaatgcc tgtttctatg gctaaaacct 23640
ccgtagattg taatatgtac atctgcggag attctactga atgtgctaat ttgcttctcc 23700
aatatggtag cttttgcaca caactaaatc gtgcactctc aggtattgct gctgaacagg 23760
atcgcaacac acgtgaagtg ttcgctcaag tcaaacaaat gtacaaaacc ccaactttga 23820
aatattttgg tggttttaat ttttcacaaa tattacctga ccctctaaag ccaactaaga 23880
ggtcttttat tgaggacttg ctctttaata aggtgacact cgctgatgct ggcttcatga 23940
agcaatatgg cgaatgccta ggtgatatta atgctagaga tctcatttgt gcgcagaagt 24000
tcaatggact tacagtgttg ccacctctgc tcactgatga tatgattgct gcctacactg 24060
ctgctctagt tagtggtact gccactgctg gatggacatt tggtgctggc gctgctcttc 24120
aaataccttt tgctatgcaa atggcatata ggttcaatgg cattggagtt acccaaaatg 24180
ttctctatga gaaccaaaaa caaatcgcca accaatttaa caaggcgatt agtcaaattc 24240
aagaatcact tacaacaaca tcaactgcat tgggcaagct gcaagacgtt gttaaccaga 24300
atgctcaagc attaaacaca cttgttaaac aacttagctc taattttggt gcaatttcaa 24360
gtgtgctaaa tgatatcctt tcgcgacttg ataaagtcga ggcggaggta caaattgaca 24420
ggttaattac aggcagactt caaagccttc aaacctatgt aacacaacaa ctaatcaggg 24480
ctgctgaaat cagggcttct gctaatcttg ctgctactaa aatgtctgag tgtgttcttg 24540
gacaatcaaa aagagttgac ttttgtggaa agggctacca ccttatgtcc ttcccacaag 24600
cagccccgca tggtgttgtc ttcctacatg tcacgtatgt gccatcccag gagaggaact 24660
tcaccacagc gccagcaatt tgtcatgaag gcaaagcata cttccctcgt gaaggtgttt 24720
ttgtgtttaa tggcacttct tggtttatta cacagaggaa cttcttttct ccacaaataa 24780
ttactacaga caatacattt gtctcaggaa attgtgatgt cgttattggc atcattaaca 24840
acacagttta tgatcctctg caacctgagc ttgactcatt caaagaagag ctggacaagt 24900
acttcaaaaa tcatacatca ccagatgttg atcttggcga catttcaggc attaacgctt 24960
ctgtcgtcaa cattcaaaaa gaaattgacc gcctcaatga ggtcgctaaa aatttaaatg 25020
aatcactcat tgaccttcaa gaattgggaa aatatgagca atatattaaa tggccttggt 25080
atgtttggct cggcttcatt gctggactaa ttgccatcgt catggttaca atcttgcttt 25140
gttgcatgac tagttgttgc agttgcctca agggtgcatg ctcttgtggt tcttgctgca 25200
agtttgatga ggatgactct gagccagttc tcaagggtgt caaattacat tacacataaa 25260
cgaacttatg gatttgttta tgagattttt tactcttgga tcaattactg cacagccagt 25320
aaaaattgac aatgcttctc ctgcaagtac tgttcatgct acagcaacga taccgctaca 25380
agcctcactc cctttcggat ggcttgttat tggcgttgca tttcttgctg tttttcagag 25440
cgctaccaaa ataattgcgc tcaataaaag atggcagcta gccctttata agggcttcca 25500
gttcatttgc aatttactgc tgctatttgt taccatctat tcacatcttt tgcttgtcgc 25560
tgcaggtatg gaggcgcaat ttttgtacct ctatgccttg atatattttc tacaatgcat 25620
caacgcatgt agaattatta tgagatgttg gctttgttgg aagtgcaaat ccaagaaccc 25680
attactttat gatgccaact actttgtttg ctggcacaca cataactatg actactgtat 25740
accatataac agtgtcacag atacaattgt cgttactgaa ggtgacggca tttcaacacc 25800
aaaactcaaa gaagactacc aaattggtgg ttattctgag gataggcact caggtgttaa 25860
agactatgtc gttgtacatg gctatttcac cgaagtttac taccagcttg agtctacaca 25920
aattactaca gacactggta ttgaaaatgc tacattcttc atctttaaca agcttgttaa 25980
agacccaccg aatgtgcaaa tacacacaat cgacggctct tcaggagttg ctaatccagc 26040
aatggatcca atttatgatg agccgacgac gactactagc gtgcctttgt aagcacaaga 26100
aagtgagtac gaacttatgt actcattcgt ttcggaagaa acaggtacgt taatagttaa 26160
tagcgtactt ctttttcttg ctttcgtggt attcttgcta gtcacactag ccatccttac 26220
tgcgcttcga ttgtgtgcgt actgctgcaa tattgttaac gtgagtttag taaaaccaac 26280
ggtttacgtc tactcgcgtg ttaaaaatct gaactcttct gaaggagttc ctgatcttct 26340
ggtctaaacg aactaactat tattattatt ctgtttggaa ctttaacatt gcttatcatg 26400
gcagacaacg gtactattac cgttgaggag cttaaacaac tcctggaaca atggaaccta 26460
gtaataggtt tcctattcct agcctggatt atgttactac aatttgccta ttctaatcgg 26520
aacaggtttt tgtacataat aaagcttgtt ttcctctggc tcttgtggcc agtaacactt 26580
gcttgttttg tgcttgctgc tgtctacaga attaattggg tgactggcgg gattgcgatt 26640
gcaatggctt gtattgtagg cttgatgtgg cttagctact tcgttgcttc cttcaggctg 26700
tttgctcgta cccgctcaat gtggtcattc aacccagaaa caaacattct tctcaatgtg 26760
cctctccggg ggacaattgt gaccagaccg ctcatggaaa gtgaacttgt cattggtgct 26820
gtgatcattc gtggtcactt gcgaatggcc ggacactccc tagggcgctg tgacattaag 26880
gacctgccaa aagagatcac tgtggctaca tcacgaacgc tttcttatta caaattagga 26940
gcgtcgcagc gtgtaggcac tgattcaggt tttgctgcat acaaccgcta ccgtattgga 27000
aactataaat taaatacaga ccacgccggt agcaacgaca atattgcttt gctagtacag 27060
taagtgacaa cagatgtttc atcttgttga cttccaggtt acaatagcag agatattgat 27120
tatcattatg aggactttca ggattgctat ttggaatctt gacgttataa taagttcaat 27180
agtgagacaa ttatttaagc ctctaactaa gaagaattat tcggagttag atgatgaaga 27240
acctatggag ttagattatc cataaaacga acatgaaaat tattctcttc ctgacattga 27300
ttgtatttac atcttgcgag ctatatcact atcaggagtg tgttagaggt acgactgtac 27360
tactaaaaga accttgccca tcaggaacat acgagggcaa ttcaccattt caccctcttg 27420
ctgacaataa atttgcacta acttgcacta gcacacactt tgcttttgct tgtgctgacg 27480
gtactcgaca tacctatcag ctgcgtgcaa gatcagtttc accaaaactt ttcatcagac 27540
aagaggaggt tcaacaagag ctctactcgc cactttttct cattgttgct gctctagtat 27600
ttttaatact ttgcttcacc attaagagaa agacagaatg aatgagctca ctttaattga 27660
cttctatttg tgctttttag cctttctgct attccttgtt ttaataatgc ttattatatt 27720
ttggttttca ctcgaaatcc aggatctaga agaaccttgt accaaagtct aaacgaacat 27780
gaaacttctc attgttttga cttgtatttc tctatgcagt tgcatatgca ctgtagtaca 27840
gcgctgtgca tctaataaac ctcatgtgct tgaagatcct tgtaaggtac aacactaggg 27900
gtaatactta tagcactgct tggctttgtg ctctaggaaa ggttttacct tttcatagat 27960
ggcacactat ggttcaaaca tgcacaccta atgttactat caactgtcaa gatccagctg 28020
gtggtgcgct tatagctagg tgttggtacc ttcatgaagg tcaccaaact gctgcattta 28080
gagacgtact tgttgtttta aataaacgaa caaattaaaa tgtctgataa tggaccccaa 28140
tcaaaccaac gtagtgcccc ccgcattaca tttggtggac ccacagattc aactgacaat 28200
aaccagaatg gaggacgcaa tggggcaagg ccaaaacagc gccgacccca aggtttaccc 28260
aataatactg cgtcttggtt cacagctctc actcagcatg gcaaggagga acttagattc 28320
cctcgaggcc agggcgttcc aatcaacacc aatagtggtc cagatgacca aattggctac 28380
taccgaagag ctacccgacg agttcgtggt ggtgacggca aaatgaaaga gctcagcccc 28440
agatggtact tctattacct aggaactggc ccagaagctt cacttcccta cggcgctaac 28500
aaagaaggca tcgtatgggt tgcaactgag ggagccttga atacacccaa agaccacatt 28560
ggcacccgca atcctaataa caatgctgcc accgtgctac aacttcctca aggaacaaca 28620
ttgccaaaag gcttctacgc agagggaagc agaggcggca gtcaagcctc ttctcgctcc 28680
tcatcacgta gtcgcggtaa ttcaagaaat tcaactcctg gcagcagtag gggaaattct 28740
cctgctcgaa tggctagcgg aggtggtgaa actgccctcg cgctattgct gctagacaga 28800
ttgaaccagc ttgagagcaa agtttctggt aaaggccaac aacaacaagg ccaaactgtc 28860
actaagaaat ctgctgctga ggcatctaaa aagcctcgcc aaaaacgtac tgccacaaaa 28920
cagtacaacg tcactcaagc atttgggaga cgtggtccag aacaaaccca aggaaatttc 28980
ggggaccaag acctaatcag acaaggaact gattacaaac attggccgca aattgcacaa 29040
tttgctccaa gtgcctctgc attctttgga atgtcacgca ttggcatgga agtcacacct 29100
tcgggaacat ggctgactta tcatggagcc attaaattgg atgacaaaga tccacaattc 29160
aaagacaacg tcatactgct gaacaagcac attgacgcat acaaaacatt cccaccaaca 29220
gagcctaaaa aggacaaaaa gaaaaagact gatgaagctc agcctttgcc gcagagacaa 29280
aagaagcagc ccactgtgac tcttcttcct gcggctgaca tggatgattt ctccagacaa 29340
cttcaaaatt ccatgagtgg agcttctgct gattcaactc aggcataaac actcatgatg 29400
accacacaag gcagatgggc tatgtaaacg ttt tcgcaat tccgtttacg atacatagtc 29460
tactcttgtg cagaatgaat tctcgtaact aaacagcaca agtaggttta gttaacttta 29520
atctcacata gcaatcttta atcaatgtgt aacattaggg aggacttgaa agagccacca 29580
cattttcatc gaggccacgc ggagtacgat cgagggtaca gtgaataatg ctagggagag 29640
ctgcctatat ggaagagccc taatgtgtaa aattaatttt agtagtgcta tccccatgtg 29700
attttaatag cttcttagga gaatgacaaa aaaaaaaaaa aaaa
<110>杭州新瑞佳生物医药技术开发有限公司
<120>针对SARS病毒的SiRNA分子
<160>129
<210>2
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>2
uggaagcgac agcaauuagt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>3
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>3
cuccuggaag cgacagcaat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>4
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>4
uaaauugccu uccucaucct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<211>21
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<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>5
guuagacaua guaugccuct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>6
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<212>RNA
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<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>6
agucucuuca uguugguagt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
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<212>RNA
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<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>7
cagcaaccgc uggacaauct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
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<212>RNA
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<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>8
gucaccaucu acucuaaact t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>9
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<212>RNA
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<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>9
gcauagacua aaucagccat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
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<212>RNA
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<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>10
gaagucauac caauccuuct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>11
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<212>RNA
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<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>11
uacgaaguca uaccaaucct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>12
<211>21
<212>RNA
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<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>12
uacgcguaag augucaggat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>13
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>13
gcguacacgc ucaccuaagt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>14
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>14
aucgcagaau uguacaguct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>15
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>15
cacgcauagc aucgcagaat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>16
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>16
aucaccgaaa ucguaccagt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>17
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>17
cgaagagaca aagucucuct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>18
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>18
acaccuauca uccaaacagt t 21 14002…14023
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>19
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>19
gagacgcgag cuauguaagt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>20
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>20
uucaacagaa cuuccuucct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>21
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>21
ccugagcaaa gaagaagugt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>22
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>22
auaaucacug auagcagcgt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>23
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>23
aucacacauu guuggcagat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>24
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>24
cuucaacuac gaauaggagt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>25
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>25
aacgauuacu ugguuggcat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>26
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>26
accagcugau uuauccagat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>27
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>27
cuuugcacua auggcauact t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>28
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>28
uacggugcga gcucuauuct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>29
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>29
agcuacggug cgagcucuat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>30
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>30
ucuaguggcg gcuauugact t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>31
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>31
uaggcauggc ucugucacat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>32
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>32
ggccauuauc cuaagcaugt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>33
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>33
gcaagaacaa gagaggccat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>34
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>34
guagaaacgg ugugauaagt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>35
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>35
uaauacuugc gcacacucgt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>36
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>36
ccacacauga ccaucucact t 21 15093…15114
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>37
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>37
cggaugaugu uccaccuggt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>38
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>38
guagcaucac cggaugaugt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>39
<211>21
<212>RNA
<213>人工序列
<220>
<22 1>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>39
uuacauuggc uguaacagct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>40
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>40
gacauacuug ucagcuauct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>41
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>41
uuguagauug cggacauact t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>42
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>42
auagagccug uguuguagat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>43
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>43
gacacucaua gagccugugt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>44
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>44
uugagccgca uaguuacugt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>45
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>45
uaaaccuuga gccgcauagt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>46
<211>21
<212>RNA
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<223>双链,表中所列为反义链序列
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
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<212>RNA
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<223>双链,表中所列为反义链序列
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<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
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<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>88
gugaguugau cugcaugaat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>89
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>89
cuccuauaag acagccugct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>90
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<212>RNA
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<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>90
aguagguaua gcaauggugt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>91
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>91
ccauagaaac aggcauuact t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>92
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>92
uuagccauag aaacaggcat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>93
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>93
aucuccgcag auguacauat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>94
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>94
ggagaagcaa auuagcacat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>95
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>95
cugagagugc acgauuuagt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>96
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>96
aauaccugag agugcacgat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>97
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>97
cacguguguu gcgauccugt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>98
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>98
agcgaacacu ucacgugugt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>99
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>99
guuugacuug agcgaacact t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>100
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>100
aucagcgagu gucaccuuat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>101
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>101
agcaucagcg agugucacct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>102
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>102
uaggcauucg ccauauugct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>103
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>103
caccuaggca uucgccauat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>104
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>104
cacuguaagu ccauugaact t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>105
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>105
uggcaacacu guaaguccat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>106
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>106
ccauugaacc uauaugccat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>107
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>107
guuaacaacg ucuugcagct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>108
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>108
cauucugguu aacaacguct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>109
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>109
uaaugcuuga gcauucuggt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>110
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>110
aagucgcgaa aggauaucat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>111
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>111
uuuguaccuc cgccucgact t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>112
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>112
cuuugaaguc ugccuguaat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>113
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>113
guuacauagg uuugaaggct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>114
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>114
ccaagaacac acucagacat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>115
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>115
gcuuugccuu caugacaaat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>116
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>116
gccaauaacg acaucacaat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>117
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>117
cagaggauca uaaacugugt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>118
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>118
ugaaugaguc aagcucaggt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>119
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>119
aguacuuguc cagcucuuct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>120
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>120
ugaaguacuu guccagcuct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>121
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>121
aauguugacg acagaagcgt t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>122
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>122
auugaggcgg ucaauuucut t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>123
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>123
cauugaggcg gucaauuuct t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>124
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>124
accucauuga ggcggucaat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>125
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>125
cuugaagguc aaugagugat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>126
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>126
gccaaacaua ccaaggccat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>127
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>127
guaaccauga cgauggcaat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>128
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>128
gucaugcaac aaagcaagat t 21
<110>杭州新瑞佳生物医药技术开发有限公司
<120>攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)及其应用
<160>129
<210>129
<211>21
<212>RNA
<213>人工序列
<220>
<221>misc_feature
<222>1...21
<223>双链,表中所列为反义链序列
<400>129
agagucaucc ucaucaaact t 21
Claims (142)
1、攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),它为双链RNA分子并且其核苷酸序列与具有以下特征的核苷酸序列(I)至少70%的同源度:正义链和负义链的长度均为21个核苷酸,正义链和负义链各自的3’端为两个连续的脱氧胸苷酸(TT),两条链除去3’端的TT以外的19个核苷酸上的碱基互补形成双链,正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒mRNA分子中连续两个碱基为腺嘌呤(A)的核苷酸之后的19个核苷酸序列完全一致,每条链中的碱基为鸟嘌呤(G)的核苷酸及胞嘧啶(C)的核苷酸数量之和占除去3’端的TT以外的19个核苷酸数量的比例为大于30%小于70%(即G/C比例),核苷酸序列(I)负链和其任意一个位置的核苷酸突变体和已知人类基因和基因表达片段无同源性。
2、权利要求1所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)还具有以下特征:其正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒多功能聚合酶mRNA分子中的RNA依赖的RNA聚合酶区域的连续两个碱基为A的核苷酸之后的19个核苷酸序列完全一致,其负义链相应配合。
3、权利要求2所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)还具有以下特征:它的G/C比例为大于40%小于60%;它的正义链5’端是以碱基为鸟嘌呤(G)、胞嘧啶(C)、或尿嘧啶(U)的核苷酸中的一种开头,其负义链相应配合;其序列中不具有连续三个以上碱基为G或C的核苷酸也不具有连续四个以上碱基为A或U的核苷酸。
4、权利要求1所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)还具有以下特征:其正义链自5’端开始的19个核苷酸序列和被攻击的SARS病毒刺蛋白(S蛋白)mRNA分子中的连续两个碱基为A的核苷酸之后的19个核苷酸序列完全一致,其负义链相应配合。
5、权利要求4所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)还具有以下特征:它的G/C比例为大于40%小于60%;它的正义链5’端是以碱基为鸟嘌呤(G)、胞嘧啶(C)、或尿嘧啶(U)的核苷酸中的一种开头,其负义链相应配合;其序列中不具有连续三个以上碱基为G或C的核苷酸也不具有连续四个以上碱基为A或U的核苷酸。
6、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CUAAUUGCUGUCGCUUCCATT,反义链:UGGAAGCGACAGCAAUUAGTT。
7、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UUGCUGUCGCUUCCAGGAGTT,反义链:CUCCUGGAAGCGACAGCAATT。
8、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GGAUGAGGAAGGCAAUUUATT,反义链:UAAAUUGCCUUCCUCAUCCTT。
9、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GAGGCAUACUAUGUCUAACTT,反义链:GUUAGACAUAGUAUGCCUCTT。
10、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CUACCAACAUGAAGAGACUTT,反义链:AGUCUCUUCAUGUUGGUAGTT。
11、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GAUUGUCCAGCGGUUGCUGTT,反义链:CAGCAACCGCUGGACAAUCTT。
12、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GUUUAGAGUAGAUGGUGACTT,反义链:GUCACCAUCUACUCUAAACTT。
13、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGGCUGAUUUAGUCUAUGCTT,反义链:GCAUAGACUAAAUCAGCCATT。
14、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GAAGGAUUGGUAUGACUUCTT,反义链:GAAGUCAUACCAAUCCUUCTT。
15、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GGAUUGGUAUGACUUCGUATT,反义链:UACGAAGUCAUACCAAUCCTT。
16、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UCCUGACAUCUUACGCGUATT,反义链:UACGCGUAAGAUGUCAGGATT。
17、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CUUAGGUGAGCGUGUACGCTT,反义链:GCGUACACGCUCACCUAAGTT。
18、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GACUGUACAAUUCUGCGAUTT,反义链:AUCGCAGAAUUGUACAGUCTT。
19、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UUCUGCGAUGCUAUGCGUGTT,反义链:CACGCAUAGCAUCGCAGAATT。
20、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CUGGUACGAUUUCGGUGAUTT,反义链:AUCACCGAAAUCGUACCAGTT。
21、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GAGAGACUUUGUCUCUUCGTT,反义链:CGAAGAGACAAAGUCUCUCTT。
22、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CUGUUUGGAUGAUAGGUGUTT,反义链:ACACCUAUCAUCCAAACAGTT。
23、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CUUACAUAGCUCGCGUCUCTT,反义链:GAGACGCGAGCUAUGUAAGTT。
24、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GGAAGGAAGUUCUGUUGAATT,反义链:UUCAACAGAACUUCCUUCCTT。
25、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CACUUCUUCUUUGCUCAGGTT,反义链:CCUGAGCAAAGAAGAAGUGTT。
26、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CGCUGCUAUCAGUGAUUAUTT,反义链:AUAAUCACUGAUAGCAGCGTT。
27、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UCUGCCAACAAUGUGUGAUTT,反义链:AUCACACAUUGUUGGCAGATT。
28、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CUCCUAUUCGUAGUUGAAGTT,反义链:CUUCAACUACGAAUAGGAGTT。
29、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGCCAACCAAGUAAUCGUUTT,反义链:AACGAUUACUUGGUUGGCATT。
30、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UCUGGAUAAAUCAGCUGGUTT,反义链:ACCAGCUGAUUUAUCCAGATT。
31、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GUAUGCCAUUAGUGCAAAGTT,反义链:CUUUGCACUAAUGGCAUACTT。
32、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GAAUAGAGCUCGCACCGUATT,反义链:UACGGUGCGAGCUCUAUUCTT。
33、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UAGAGCUCGCACCGUAGCUTT,反义链:AGCUACGGUGCGAGCUCUATT。
34、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GUCAAUAGCCGCCACUAGATT,反义链:UCUAGUGGCGGCUAUUGACTT。
35、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGUGACAGAGCCAUGCCUATT,反义链:。UAGGCAUGGCUCUGUCACATT
36、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CAUGCUUAGGAUAAUGGCCTT,反义链:GGCCAUUAUCCUAAGCAUGTT。
37、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGGCCUCUCUUGUUCUUGCTT,反义链:GCAAGAACAAGAGAGGCCATT。
38、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CUUAUCACACCGUUUCUACTT,反义链:GUAGAAACGGUGUGAUAAGTT。
39、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CGAGUGUGCGCAAGUAUUATT,反义链:UAAUACUUGCGCACACUCGTT。
40、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GUGAGAUGGUCAUGUGUGGTT,反义链:CCACACAUGACCAUCUCACTT。
41、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CCAGGUGGAACAUCAUCCGTT,反义链:CGGAUGAUGUUCCACCUGGTT。
42、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CAUCAUCCGGUGAUGCUACTT,反义链:GUAGCAUCACCGGAUGAUGTT。
43、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GCUGUUACAGCCAAUGUAATT,反义链:UUACAUUGGCUGUAACAGCTT。
44、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GAUAGCUGACAAGUAUGUCTT,反义链:GACAUACUUGUCAGCUAUCTT。
45、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GUAUGUCCGCAAUCUACAATT,反义链:UUGUAGAUUGCGGACAUACTT。
46、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UCUACAACACAGGCUCUAUTT,反义链:AUAGAGCCUGUGUUGUAGATT。
47、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CACAGGCUCUAUGAGUGUCTT,反义链:GACACUCAUAGAGCCUGUGTT。
48、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CAGUAACUAUGCGGCUCAATT,反义链:UUGAGCCGCAUAGUUACUGTT。
49、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CUAUGCGGCUCAAGGUUUATT,反义链:UAAACCUUGAGCCGCAUAGTT。
50、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGUGUUCAUGUCUGAGGCATT,反义链:UGCCUCAGACAUGAACACATT。
51、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGUUGGACUGAGACUGACCTT,反义链:GGUCAGUCUCAGUCCAACATT。
52、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CAAGGAGAUGAUUACGUGUTT,反义链:ACACGUAAUCAUCUCCUUGTT。
53、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GGAGAUGAUUACGUGUACCTT,反义链:GGUACACGUAAUCAUCUCCTT。
54、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GAAUAUUAGGCGCAGGCUGTT,反义链:CAGCCUGCGCCUAAUAUUCTT。
55、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UAUUAGGCGCAGGCUGUUUTT,反义链:AAACAGCCUGCGCCUAAUATT。
56、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GGUUCGUGUCACUGGCUAUTT,反义链:AUAGCCAGUGACACGAACCTT。
57、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CAUCCUAAUCAGGAGUAUGTT,反义链:CAUACUCCUGAUUAGGAUGTT。
58、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CUAAUGAUAACACCUCACGTT,反义链:CGUGAGGUGUUAUCAUUAGTT。
59、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGAUAACACCUCACGGUACTT,反义链:GUACCGUGAGGUGUUAUCATT。
60、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UUCACAGACUUCACUUCGUTT,反义链:ACGAAGUGAAGUCUGUGAATT。
61、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GUGCUGCUAUGACCAUGUCTT,反义链:GACAUGGUCAUAGCAGCACTT。
62、权利要求3所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CUGUAUCUAGGAGGUAUGATT,反义链:UCAUACCUCCUAGAUACAGTT。
63、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GCUCCUAAUUACACUCAACTT,反义链:GUUGAGUGUAAUUAGGAGCTT。
64、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UCAAAUGUUGUCCGUGGUUTT,反义链:AACCACGGACAACAUUUGATT。
65、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CAACAAGUCACAGUCGGUGTT,反义链:CACCGACUGUGACUUGUUGTT。
66、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CAAGUCACAGUCGGUGAUUTT,反义链:AAUCACCGACUGUGACUUGTT。
67、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GUCACAGUCGGUGAUUAUUTT,反义链:AAUAAUCACCGACUGUGACTT。
68、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CACUUACGAGAGUUUGUGUTT,反义链:ACACAAACUCUCGUAAGUGTT。
69、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CCUAUAGAUGUAGUUCGUGTT,反义链:CACGAACUACAUCUAUAGGTT。
70、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GUUGCCUCUUGGUAUUAACTT,反义链:GUUAAUACCAAGAGGCAACTT。
71、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GCCAACUACAUUUAUGCUCTT,反义链:GAGCAUAAAUGUAGUUGGCTT。
72、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGGUACAAUCACAGAUGCUTT,反义链:AGCAUCUGUGAUUGUACCATT。
73、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UCACAGAUGCUGUUGAUUGTT,反义链:CAAUCAACAGCAUCUGUGATT。
74、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UCCACUUGCUGAACUCAAATT,反义链:UUUGAGUUCAGCAAGUGGATT。
75、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGCUCUGUUAAGAGCUUUGTT,反义链:CAAAGCUCUUAACAGAGCATT。
76、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GGAAUUUACCAGACCUCUATT,反义链:UAGAGGUCUGGUAAAUUCCTT。
77、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CCUUUAAGUGCUAUGGCGUTT,反义链:ACGCCAUAGCACUUAAAGGTT。
78、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GUGCUAUGGCGUUUCUGCCTT,反义链:GGCAGAAACGCCAUAGCACTT。
79、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GACAAAUAGCGCCAGGACATT,反义链:UGUCCUGGCGCUAUUUGUCTT。
80、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UAGCGCCAGGACAAACUGGTT,反义链:CCAGUUUGUCCUGGCGCUATT。
81、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UUGCCAGAUGAUUUCAUGGTT,反义链:CCAUGAAAUCAUCUGGCAATT。
82、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CCUUACAGAGUUGUAGUACTT,反义链:GUACUACAACUCUGUAAGGTT。
83、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGGACUCACUGGUACUGGUTT,反义链:ACCAGUACCAGUGAGUCCATT。
84、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CCAUUUCAACAAUUUGGCCTT,反义链:GGCCAAAUUGUUGAAAUGGTT。
85、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CAAUUUGGCCGUGAUGUUUTT,反义链:AAACAUCACGGCCAAAUUGTT。
86、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UUUGGCCGUGAUGUUUCUGTT,反义链:CAGAAACAUCACGGCCAAATT。
87、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GUGUAAUUACACCUGGAACTT,反义链:GUUCCAGGUGUAAUUACACTT。
88、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UUACACCUGGAACAAAUGCTT,反义链:GCAUUUGUUCCAGGUGUAATT。
89、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGCUUCAUCUGAAGUUGCUTT,反义链:AGCAACUUCAGAUGAAGCATT。
90、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GAUGUUAACUGCACUGAUGTT,反义链:CAUCAGUGCAGUUAACAUCTT。
91、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CUGCACUGAUGUUUCUACATT,反义链:UGUAGAAACAUCAGUGCAGTT。
92、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UUCAUGCAGAUCAACUCACTT,反义链:GUGAGUUGAUCUGCAUGAATT。
93、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GCAGGCUGUCUUAUAGGAGTT,反义链:CUCCUAUAAGACAGCCUGCTT。
94、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CACCAUUGCUAUACCUACUTT,反义链:AGUAGGUAUAGCAAUGGUGTT。
95、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GUAAUGCCUGUUUCUAUGGTT,反义链:CCAUAGAAACAGGCAUUACTT。
96、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGCCUGUUUCUAUGGCUAATT,反义链:UUAGCCAUAGAAACAGGCATT。
97、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UAUGUACAUCUGCGGAGAUTT,反义链:AUCUCCGCAGAUGUACAUATT。
98、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGUGCUAAUUUGCUUCUCCTT,反义链:GGAGAAGCAAAUUAGCACATT。
99、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CUAAAUCGUGCACUCUCAGTT,反义链:CUGAGAGUGCACGAUUUAGTT。
100、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UCGUGCACUCUCAGGUAUUTT,反义链:AAUACCUGAGAGUGCACGATT。
101、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CAGGAUCGCAACACACGUGTT,反义链:CACGUGUGUUGCGAUCCUGTT。
102、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CACACGUGAAGUGUUCGCUTT,反义链:AGCGAACACUUCACGUGUGTT。
103、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GUGUUCGCUCAAGUCAAACTT,反义链:GUUUGACUUGAGCGAACACTT。
104、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UAAGGUGACACUCGCUGAUTT,反义链:AUCAGCGAGUGUCACCUUATT。
105、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GGUGACACUCGCUGAUGCUTT,反义链:AGCAUCAGCGAGUGUCACCTT。
106、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GCAAUAUGGCGAAUGCCUATT,反义链:UAGGCAUUCGCCAUAUUGCTT。
107、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UAUGGCGAAUGCCUAGGUGTT,反义链:CACCUAGGCAUUCGCCAUATT。
108、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GUUCAAUGGACUUACAGUGTT,反义链:CACUGUAAGUCCAUUGAACTT。
109、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGGACUUACAGUGUUGCCATT,反义链:UGGCAACACUGUAAGUCCATT。
110、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGGCAUAUAGGUUCAAUGGTT,反义链:CCAUUGAACCUAUAUGCCATT。
111、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GCUGCAAGACGUUGUUAACTT,反义链:GUUAACAACGUCUUGCAGCTT。
112、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GACGUUGUUAACCAGAAUGTT,反义链:CAUUCUGGUUAACAACGUCTT。
113、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CCAGAAUGCUCAAGCAUUATT,反义链:UAAUGCUUGAGCAUUCUGGTT。
114、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGAUAUCCUUUCGCGACUUTT,反义链:AAGUCGCGAAAGGAUAUCATT。
115、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GUCGAGGCGGAGGUACAAATT,反义链:UUUGUACCUCCGCCUCGACTT。
116、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UUACAGGCAGACUUCAAAGTT,反义链:CUUUGAAGUCUGCCUGUAATT。
117、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GCCUUCAAACCUAUGUAACTT,反义链:GUUACAUAGGUUUGAAGGCTT。
118、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGUCUGAGUGUGUUCUUGGTT,反义链:CCAAGAACACACUCAGACATT。
119、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UUUGUCAUGAAGGCAAAGCTT,反义链:GCUUUGCCUUCAUGACAAATT。
120、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UUGUGAUGUCGUUAUUGGCTT,反义链:GCCAAUAACGACAUCACAATT。
121、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CACAGUUUAUGAUCCUCUGTT,反义链:CAGAGGAUCAUAAACUGUGTT。
122、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CCUGAGCUUGACUCAUUCATT,反义链:UGAAUGAGUCAAGCUCAGGTT。
123、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GAAGAGCUGGACAAGUACUTT,反义链:AGUACUUGUCCAGCUCUUCTT。
124、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GAGCUGGACAAGUACUUCATT,反义链:UGAAGUACUUGUCCAGCUCTT。
125、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:CGCUUCUGUCGUCAACAUUTT,反义链:AAUGUUGACGACAGAAGCGTT。
126、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:AGAAAUUGACCGCCUCAAUTT,反义链:AUUGAGGCGGUCAAUUUCUTT。
127、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GAAAUUGACCGCCUCAAUGTT,反义链:CAUUGAGGCGGUCAAUUUCTT。
128、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UUGACCGCCUCAAUGAGGUTT,反义链:ACCUCAUUGAGGCGGUCAATT。
129、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UCACUCAUUGACCUUCAAGTT,反义链:CUUGAAGGUCAAUGAGUGATT。
130、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UGGCCUUGGUAUGUUUGGCTT,反义链:GCCAAACAUACCAAGGCCATT。
131、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UUGCCAUCGUCAUGGUUACTT,反义链:GUAACCAUGACGAUGGCAATT。
132、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:UCUUGCUUUGUUGCAUGACTT,反义链:GUCAUGCAACAAAGCAAGATT。
133、权利要求5所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),核苷酸序列(I)为:
正义链:GUUUGAUGAGGAUGACUCUTT,反义链:AGAGUCAUCCUCAUCAAACTT。
134、权利要求1至133中的任一所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),所述同源度以80%以上为佳。
135、权利要求1至133中的任一所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)的任何部份或全部经化学修饰后所形成的的小干扰核糖核酸分子。
136、权利要求135所述的攻击严重急性呼吸系统综合症(SARS)病毒的小干扰核糖核酸分子(SiRNA),所述化学修饰包括对连接核苷酸的磷酸二酯键的部份修饰或用其它任何化学键取代。
137、权利要求135所述的攻攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA),所述化学修饰包括对这些SiRNA分子侧链上核糖的2位上的0H作任何化学的修饰和改变,和碱基上任何位置作化学修饰或改变。
138、权利要求1至133中的任一所述的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)在制备治疗SARS以及与SARS感染相关的任何疾病的药物中的应用。
139、权利要求134中的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)在制备治疗SARS以及与SARS感染相关的任何疾病的药物中的应用。
140、权利要求135中的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)在制备治疗SARS以及与SARS感染相关的任何疾病的药物中的应用。
141、权利要求136中的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)在制备治疗SARS以及与SARS感染相关的任何疾病的药物中的应用。
142、权利要求137中的攻击严重急性呼吸系统综合症(SARS)病毒mRNA分子的小干扰核糖核酸分子(SiRNA)在制备治疗SARS以及与SARS感染相关的任何疾病的药物中的应用。
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