CN1589786A - Composite effervescent preparation containing soya isoflavone - Google Patents
Composite effervescent preparation containing soya isoflavone Download PDFInfo
- Publication number
- CN1589786A CN1589786A CN 03156087 CN03156087A CN1589786A CN 1589786 A CN1589786 A CN 1589786A CN 03156087 CN03156087 CN 03156087 CN 03156087 A CN03156087 A CN 03156087A CN 1589786 A CN1589786 A CN 1589786A
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- Prior art keywords
- effervescent
- soybean isoflavone
- compound recipe
- effervescent formulation
- compound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A composite effervescent medicine or health food in the form of tablet or particle for preventing osteoporosis, climacteric syndrome and cardiovascular disease of woman is prepared from soybean isoflavone, vitamines, amino acids, trace elements, effervescent agent, adhesive and lubricant.
Description
Technical field
The invention belongs to the novel quick-releasing effervescence dosage form of soybean isoflavone compound preparation, can improve the stability of biological activity, quicken absorption of human body, be convenient to take, be specially adapted to sclerotin conveying, cardiovascular disease, climacteric syndrome and adult female's health care.
Background technology
Soybean isoflavone (Isoflavones of Soybeen) is mainly derived from fabaceous pod beans, and wherein containing bioactive two kinds of compositions mainly is that genistein (claims genistein again, genistein) with big legumin (daidgein).The crude soya bean isoflavone is divided into free type aglycon (Aglycon) and conjunction type glucosides (Glucosides) two classes exist.
The aglycon of soybean isoflavone generally is insoluble in or is water insoluble, and conjunction type glycosides dissolubility in water strengthens, and dissolves in hot water.Because poorly water-soluble has reduced human body it has been absorbed.Be processed into the effervescent Expidet, can improve the dissolubility of soybean isoflavone greatly, increase human body it is absorbed.
The active component of soybean isoflavone has different physiological roles, and its major function has two aspects, phytoestrogen function and anti-oxidation function.Main active component Genistein and Daidgein are structurally to mammiferous estrogen---estradiol is similar, therefore be called as " phytoestrogen ", additional soybean isoflavone can prevent and the some diseases relevant with estrogen such as auxiliary treatment climacteric syndrome, osteoporosis, breast carcinoma, uterus carcinoma, carcinoma of prostate.
Soybean isoflavone is a kind of plant polyphenol, have a plurality of phenolic hydroxyl groups, its anti-oxidation function has different performances in different oxidation systems, have stronger oxidation resistance and good removing free radical ability, thereby can form stable free radical intermediate blocking-up radical reaction, it can also promote SOD formation in vivo simultaneously.So the soybean isoflavone disease that peroxidating causes to body lipid all has certain prevention and auxiliary treatment effect as hyperlipidemia, atherosclerosis, coronary heart disease etc.
Summary of the invention
The objective of the invention is physiology and biochemical characteristic according to soybean isoflavone, selection has the biological active substances that strengthens the soybean isoflavone function, form compound preparation, and be processed into instant effervescent formulation, said preparation has no side effect, can take for a long time, can prevent and auxiliary treatment osteoporosis, cardiovascular disease, climacteric syndrome, be particularly suitable for adult female's health care.
The soybean isoflavone that the present invention adopts extracts from leguminous plant, as Semen sojae atricolor, Radix Puerariae etc.Soybean extract particularly, content range is 10～90%, is preferably 60%.Can be total flavones, or activated monomer, be preferably total flavones.
Other active component that the present invention adopts comprises vitamin, trace element, aminoacid, L-carnitine etc.The vitamin of selecting for use comprises vitamin C, vitamin E, vitamin B
1, B
2, B
6, vitamin D, folic acid, Citrin, biotin etc.Preferably vitamin C, vitamin E and folic acid, vitamin D, content range is respectively 0.5～30%, and preferably 5～15%.
The trace element that the present invention selects for use has calcium salt, zinc salt, iron salt etc., is generally calcium lactate, calcium gluconate, calcium ascorbate, zinc lactate, ferrous lactate etc., and content range is respectively 0.01～10%, and preferably 0.1～5%.
The freshly prepd effervescent formulation of the present invention comprises effervescent tablet and effervescent granule, be after soybean isoflavone and other active ingredients are mixed by a certain percentage, add effervescent adjuvants such as citric acid, malic acid, sodium carbonate, sodium bicarbonate, and add corresponding adhesive, through mixing, pack behind granulation, drying, the granulate, promptly get effervescent granule.Add lubricant through abundant mixing, tabletting as the effervescent granule with gained behind the granulate, promptly get compound recipe soybean isoflavone effervescent tablet, sheet is 0.5～5g heavily, is preferably 3.0～4.5g.
The specific embodiment
Embodiment one:
Compound recipe soybean isoflavone effervescent tablet
Prescription: every contains:
Soybean isoflavone (60%) 100mg
Citric acid 1800mg
Vitamin C 300mg
Vitamin E 50IU
Sodium bicarbonate 1200mg
Polyvinylpyrrolidone (PVP) 50mg
Sweeting agent 100mg
Above-mentioned raw materials is pulverized, crossed 80～120 mesh sieves, weigh, mix, granulate, total mixed, the tabletting in dry back, sheet heavily is 4g, and every isoflavone content is 60mg, every day a slice.When taking effervescent tablet being taken out from packaging bag, put into one glass of drinking water, was solubilized in 3 minutes, drank to get final product.
Embodiment two
Compound recipe soybean isoflavone effervescent tablet
Prescription: every contains:
Soybean isoflavone (60%) 100mg
Vitamin D 100IU
Calcium lactate 300mg
Zinc lactate 50mg
Citric acid 1800mg
Malic acid 100mg
Sodium bicarbonate 1200mg
Polyvinylpyrrolidone (PVP) 50mg
Sweeting agent 150mg
Become effervescent tablet by embodiment one processes, sheet heavily is 3.8g, takes 1～2 every day.
Embodiment three
Compound recipe soybean isoflavone effervescent granule
Prescription: every bag of compound recipe soybean isoflavone effervescent granule contains:
Soybean isoflavone (40%) 200mg
Vitamin C 500mg
Vitamin E 50IU
Vitamin B
650mg
Folic acid 5mg
Vitamin D 100IU
Calcium ascorbate 200mg
L-arginine 1000mg
Citric acid 1800mg
Malic acid 200mg
Sodium bicarbonate 1200mg
Sweeting agent 600mg
Adhesive is an amount of
Above-mentioned raw materials is pulverized, crossed 80 mesh sieves, weigh, fully mix, granulate,, reduce to back below 2% to moisture and granulate, choose the every bag of 6g of granule packaging between 12～14 orders, took 1～2 bag on 1st in dry below 70 ℃.
Claims (5)
1, a kind of compound formulation that contains soybean isoflavone is characterized in that: described composite effervescent sheet is to cooperate the compound recipe effervescent formulation made from other biological active substances by the natural plant extracts that contains by soybean isoflavone.
2, compound recipe effervescent formulation according to claim 1, it is characterized in that: described soybean isoflavone is the flavone compound of extracted form natural plant, can be that total flavones also can be genistein (genistein), big legumin (daidgein) isoreactivity monomer, its ratio be 0.1～60%.
3, compound recipe effervescent formulation according to claim 1 is characterized in that: described other biological active substances comprises vitamin, trace element, aminoacid or other effective ingredient, comprises one or more chemical compounds, and its ratio is 0.5～50%.
4, compound recipe effervescent formulation according to claim 1 is characterized in that: described effervescent formulation is effervescent tablet or effervescent granule.
5, compound recipe effervescent formulation according to claim 1, it is characterized in that: described effervescent formulation is applicable to prevention of osteoporosis conveying, cardiovascular disease and climacteric syndrome, is specially adapted to adult female's health care.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03156087 CN1589786A (en) | 2003-09-01 | 2003-09-01 | Composite effervescent preparation containing soya isoflavone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03156087 CN1589786A (en) | 2003-09-01 | 2003-09-01 | Composite effervescent preparation containing soya isoflavone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1589786A true CN1589786A (en) | 2005-03-09 |
Family
ID=34598302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03156087 Pending CN1589786A (en) | 2003-09-01 | 2003-09-01 | Composite effervescent preparation containing soya isoflavone |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1589786A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101780203A (en) * | 2010-03-16 | 2010-07-21 | 刘仁杰 | Lubrication effervescent agent for yin nourishing, nest warming, body deodorizing and youth keeping and preparation method thereof |
| WO2012002918A1 (en) * | 2010-06-03 | 2012-01-05 | Mahmut Bilgic | Formulation for osteoporosis |
| WO2013043142A1 (en) * | 2011-08-08 | 2013-03-28 | Mahmut Bilgic | Production method for pharmaceutical formulations comprising an isoflavone |
| CN103110687A (en) * | 2011-11-17 | 2013-05-22 | 胡晓娟 | Compound effervescent preparation containing soy isoflavone |
| WO2013089654A1 (en) * | 2011-12-16 | 2013-06-20 | Mahmut Bilgic | Effervescent formulations comprising genistein |
| CN107373272A (en) * | 2017-07-19 | 2017-11-24 | 郑州博凯医药保健品有限公司 | Isoflavones effervescent tablet and preparation method thereof |
| CN108185430A (en) * | 2017-05-20 | 2018-06-22 | 郑毅男 | A kind of Fresh edible soybean effervesce piece preparation method |
-
2003
- 2003-09-01 CN CN 03156087 patent/CN1589786A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101780203A (en) * | 2010-03-16 | 2010-07-21 | 刘仁杰 | Lubrication effervescent agent for yin nourishing, nest warming, body deodorizing and youth keeping and preparation method thereof |
| WO2012002918A1 (en) * | 2010-06-03 | 2012-01-05 | Mahmut Bilgic | Formulation for osteoporosis |
| WO2013043142A1 (en) * | 2011-08-08 | 2013-03-28 | Mahmut Bilgic | Production method for pharmaceutical formulations comprising an isoflavone |
| WO2013074046A1 (en) * | 2011-08-08 | 2013-05-23 | Mahmut Bilgic | Pharmaceutical formulations comprising isoflavone |
| CN103110687A (en) * | 2011-11-17 | 2013-05-22 | 胡晓娟 | Compound effervescent preparation containing soy isoflavone |
| WO2013089654A1 (en) * | 2011-12-16 | 2013-06-20 | Mahmut Bilgic | Effervescent formulations comprising genistein |
| CN108185430A (en) * | 2017-05-20 | 2018-06-22 | 郑毅男 | A kind of Fresh edible soybean effervesce piece preparation method |
| CN107373272A (en) * | 2017-07-19 | 2017-11-24 | 郑州博凯医药保健品有限公司 | Isoflavones effervescent tablet and preparation method thereof |
| CN107373272B (en) * | 2017-07-19 | 2020-11-06 | 博凯药业有限公司 | Soybean isoflavone effervescent tablet and preparation method thereof |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Xu Pinghui Document name: Special business review memo |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |